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Gorilla Results Results http://cbl-gorilla.cs.technion.ac.il/GOrilla/2l4v7a1a/GOResultsPROCESS... P-value color scale > 10-3 10-3 to 10-5 10-5 to 10-7 10-7 to 10-9 < 10-9 null Description P-value Enrichment (N, B, n, b) Genes [-] Hide genes ATF3 - activating transcription factor 3 JUN - jun proto-oncogene ADM - adrenomedullin NAMPT - nicotinamide phosphoribosyltransferase GO:0008284 positive regulation of cell proliferation 6.46E-6 4.37 (297,17,40,10) C7orf68 - chromosome 7 open reading frame 68 FOSL2 - fos-like antigen 2 TNFAIP3 - tumor necrosis factor, alpha-induced protein 3 VEGFA - vascular endothelial growth factor a SOX9 - sry (sex determining region y)-box 9 EDN2 - endothelin 2 [-] Hide genes JUN - jun proto-oncogene SPRR1B - small proline-rich protein 1b GO:0030855 epithelial cell differentiation 4.33E-5 5.20 (297,10,40,7) SPRR1A - small proline-rich protein 1a PLAUR - plasminogen activator, urokinase receptor VEGFA - vascular endothelial growth factor a TXNIP - thioredoxin interacting protein ELF3 - e74-like factor 3 (ets domain transcription factor, epithelial-specific ) [-] Hide genes JUN - jun proto-oncogene KHDRBS1 - kh domain containing, rna binding, signal transduction associated 1 MAFF - v-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian) VEGFA - vascular endothelial growth factor a RRAS - related ras viral (r-ras) oncogene homolog SOX9 - sry (sex determining region y)-box 9 SAT1 - spermidine/spermine n1-acetyltransferase 1 GEM - gtp binding protein overexpressed in skeletal muscle GO:0006807 nitrogen compound metabolic process 1.77E-4 2.16 (297,62,40,18) ATF3 - activating transcription factor 3 ADM - adrenomedullin BHLHE40 - basic helix-loop-helix family, member e40 CYP1A1 - cytochrome p450, family 1, subfamily a, polypeptide 1 NAMPT - nicotinamide phosphoribosyltransferase FOSL2 - fos-like antigen 2 DDIT3 - dna-damage-inducible transcript 3 NFIL3 - nuclear factor, interleukin 3 regulated TIPARP - tcdd-inducible poly(adp-ribose) polymerase ELF3 - e74-like factor 3 (ets domain transcription factor, epithelial-specific ) GO:0048511 rhythmic process 2.59E-4 4.95 (297,9,40,6) [+] Show genes GO:0006139 nucleobase-containing compound metabolic process 3.29E-4 2.32 (297,48,40,15) [+] Show genes GO:0060255 regulation of macromolecule metabolic process 3.58E-4 1.88 (297,83,40,21) [+] Show genes GO:0006355 regulation of transcription, DNA-dependent 3.88E-4 2.20 (297,54,40,16) [+] Show genes GO:0010629 negative regulation of gene expression 4.79E-4 2.97 (297,25,40,10) [+] Show genes GO:0080090 regulation of primary metabolic process 5.34E-4 1.83 (297,85,40,21) [+] Show genes GO:0010605 negative regulation of macromolecule metabolic process 6.24E-4 2.55 (297,35,40,12) [+] Show genes GO:0048523 negative regulation of cellular process 7.07E-4 1.91 (297,74,40,19) [+] Show genes GO:0009889 regulation of biosynthetic process 7.07E-4 1.97 (297,68,40,18) [+] Show genes GO:0051252 regulation of RNA metabolic process 8E-4 2.08 (297,57,40,16) [+] Show genes GO:0045892 negative regulation of transcription, DNA-dependent 8.11E-4 3.04 (297,22,40,9) [+] Show genes GO:0051253 negative regulation of RNA metabolic process 8.11E-4 3.04 (297,22,40,9) [+] Show genes GO:0044237 cellular metabolic process 9.68E-4 1.52 (297,137,40,28) [+] Show genes Species used: Homo sapiens The system has recognized 463 genes out of 496 gene terms entered by the user. 462 genes were recognized by gene symbol and 1 genes by other gene IDs . 158 duplicate genes were removed (keeping the highest ranking instance of each gene) leaving a total of 305 genes. Only 297 of these genes are associated with a GO term. The GOrilla database is periodically updated using the GO database and other sources. The GOrilla database was last updated on Sep 24, 2011 This results page will be available on this site for one month from now (until Oct 28, 2011 ). You can bookmark this page and come back to it later. 'P-value' is the enrichment p-value computed according to the null model. This p-value is not corrected for multiple testing of 2653 nulls. Enrichment (N, B, n, b) is defined as follows: N - is the total number of genes B - is the total number of genes associated with a specific null n - is the number of genes in the top of the user's input list or in the target set when appropriate b - is the number of genes in the intersection Enrichment = (b/n) / (B/N) Genes: For each null you can see the list of associated genes that appear in the optimal top of the list. 1 of 2 9/28/2011 11:17 AM Results http://cbl-gorilla.cs.technion.ac.il/GOrilla/2l4v7a1a/GOResultsFUNCTI... P-value color scale > 10-3 10-3 to 10-5 10-5 to 10-7 10-7 to 10-9 < 10-9 null Description P-value Enrichment (N, B, n, b) Genes [-] Hide genes ATF3 - activating transcription factor 3 JUN - jun proto-oncogene FOSL2 - fos-like antigen 2 DDIT3 - dna-damage-inducible transcript 3 sequence- MAFF - v-maf musculoaponeurotic fibrosarcoma GO:0043565 specific DNA 6.67E-5 3.93 (297,17,40,9) oncogene homolog f (avian) binding NFIL3 - nuclear factor, interleukin 3 regulated KDM6B - lysine (k)-specific demethylase 6b ELF3 - e74-like factor 3 (ets domain transcription factor, epithelial-specific ) SOX9 - sry (sex determining region y)-box 9 [-] Hide genes JUN - jun proto-oncogene KLF6 - kruppel-like factor 6 KHDRBS1 - kh domain GO:0003677 DNA binding 1.27E-4 2.76 (297,35,40,13) containing, rna binding, signal transduction associated 1 TNFAIP3 - tumor necrosis factor, alpha-induced protein 3 MAFF - v-maf 1 of 2 9/28/2011 11:19 AM Results http://cbl-gorilla.cs.technion.ac.il/GOrilla/2l4v7a1a/GOResultsFUNCTI... musculoaponeurotic fibrosarcoma oncogene homolog f (avian) SOX9 - sry (sex determining region y)-box 9 ATF3 - activating transcription factor 3 BHLHE40 - basic helix-loop-helix family, member e40 FOSL2 - fos-like antigen 2 DDIT3 - dna-damage-inducible transcript 3 NFIL3 - nuclear factor, interleukin 3 regulated ELF3 - e74-like factor 3 (ets domain transcription factor, epithelial-specific ) KDM6B - lysine (k)-specific demethylase 6b Species used: Homo sapiens The system has recognized 463 genes out of 496 gene terms entered by the user. 462 genes were recognized by gene symbol and 1 genes by other gene IDs . 158 duplicate genes were removed (keeping the highest ranking instance of each gene) leaving a total of 305 genes. Only 297 of these genes are associated with a GO term. The GOrilla database is periodically updated using the GO database and other sources. The GOrilla database was last updated on Sep 24, 2011 This results page will be available on this site for one month from now (until Oct 28, 2011 ). You can bookmark this page and come back to it later. 'P-value' is the enrichment p-value computed according to the null model. This p-value is not corrected for multiple testing of 645 nulls. Enrichment (N, B, n, b) is defined as follows: N - is the total number of genes B - is the total number of genes associated with a specific null n - is the number of genes in the top of the user's input list or in the target set when appropriate b - is the number of genes in the intersection Enrichment = (b/n) / (B/N) Genes: For each null you can see the list of associated genes that appear in the optimal top of the list. Each gene name is specified by gene symbol followed by a short description of the gene 2 of 2 9/28/2011 11:19 AM.
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