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FNBP1L, ID (FNBP1L, C1orf39, TOCA1, Formin-binding protein 1-like, Transducer of Cdc42-dependent actin assembly protein 1) (Azide free) (HRP) Catalog number 035701-HRP Supplier United States Biological The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. Applications Suitable for use in Western Blot, ELISA Recommended Dilution ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Note Applications are based on unconjugated antibody. Immunogen FNBP1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 348-377 amino acids from the Central region of human FNBP1L. Formulation Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with horseradish peroxidase (HRP). Purity Purified by Protein A affinity chromatography. Specificity Human, mouse Product Type Pab Source human Isotype IgG Grade Affinity Purified Applications E WB Crossreactivity Hu Mo Storage -20°C Detection Method HRP Reference Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Bu, W., et al. PLoS ONE 5 (8), E12153 (2010) : Bu, W., et al. J. Biol. Chem. 284(17):11622-11636(2009) Huett, A., et al. J. Immunol. 182(8):4917-4930(2009) Leung, Y., et al. Cell Host Microbe 3(1):39-47(2008) Powered by TCPDF (www.tcpdf.org).

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Discovery of the First Genome-Wide Significant Risk Loci for ADHD
bioRxiv preprint doi: https://doi.org/10.1101/145581; this version posted June 3, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Discovery of the first genome-wide significant risk loci for ADHD Ditte Demontis,1,2,3† Raymond K. Walters,4,5† Joanna Martin,5,6,7 Manuel Mattheisen,1,2,3,8,9 Thomas D. Als,1,2,3 Esben Agerbo,1,10,11 Rich Belliveau,5 Jonas Bybjerg-Grauholm,1,12 Marie Bækvad-Hansen,1,12 Felecia Cerrato,5 Kimberly Chambert,5 Claire Churchhouse,4,5,13 Ashley Dumont,5 Nicholas Eriksson,14 Michael Gandal,15,16,17,18 Jacqueline Goldstein,4,5,13 Jakob Grove,1,2,3,19 Christine S. Hansen,1,12,20 Mads E. Hauberg,1,2,3 Mads V. Hollegaard,1,12 Daniel P. Howrigan,4,5 Hailiang Huang,4,5 Julian Maller,5,21 Alicia R. Martin,4,5,13 Jennifer Moran,5 Jonatan Pallesen,1,2,3 Duncan S. Palmer,4,5 Carsten B. Pedersen,1,10,11 Marianne G. Pedersen,1,10,11 Timothy Poterba,4,5,13 Jesper B. Poulsen,1,12 Stephan Ripke,4,5,13,22 Elise B. Robinson,4,23 Kyle F. Satterstrom,4,5,13 Christine Stevens,5 Patrick Turley,4,5 Hyejung Won,15,16 ADHD Working Group of the Psychiatric Genomics Consortium (PGC), Early Lifecourse & Genetic Epidemiology (EAGLE) Consortium, 23andMe Research Team, Ole A.
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Human Leucine-Rich Repeat Proteins: a Genome-Wide Bioinformatic Categorization and Functional Analysis in Innate Immunity
Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity Aylwin C. Y. Nga,b,1, Jason M. Eisenberga,b,1, Robert J. W. Heatha, Alan Huetta, Cory M. Robinsonc, Gerard J. Nauc, and Ramnik J. Xaviera,b,2 aCenter for Computational and Integrative Biology, and Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114; bThe Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142; and cMicrobiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261 Edited by Jeffrey I. Gordon, Washington University School of Medicine, St. Louis, MO, and approved June 11, 2010 (received for review February 17, 2010) In innate immune sensing, the detection of pathogen-associated proteins have been implicated in human diseases to date, notably molecular patterns by recognition receptors typically involve polymorphisms in NOD2 in Crohn disease (8, 9), CIITA in leucine-rich repeats (LRRs). We provide a categorization of 375 rheumatoid arthritis and multiple sclerosis (10), and TLR5 in human LRR-containing proteins, almost half of which lack other Legionnaire disease (11). identiﬁable functional domains. We clustered human LRR proteins Most LRR domains consist of a chain of between 2 and 45 by ﬁrst assigning LRRs to LRR classes and then grouping the proteins LRRs (12). Each repeat in turn is typically 20 to 30 residues long based on these class assignments, revealing several of the resulting and can be divided into a highly conserved segment (HCS) fol- protein groups containing a large number of proteins with certain lowed by a variable segment (VS).
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Product Name: FNBP1L/TOCA1 Polyclonal Antibody, HRP Conjugated Catalog No
Product Name: FNBP1L/TOCA1 Polyclonal Antibody, HRP Conjugated Catalog No. : TAP01-88159R-HRP Intended Use: For Research Use Only. Not for used in diagnostic procedures. Size 100ul Concentration 1ug/ul Gene ID ISO Type Rabbit IgG Clone N/A Immunogen Range Conjugation HRP Subcellular Locations Applications WB, IHC-P Cross Reactive Species Human, Mouse, Rat Source KLH conjugated synthetic peptide derived from human FNBP1L/TOCA1 Applications with WB(1:100-1000), IHC-P(1:100-500) Dilutions Purification Purified by Protein A. Background TOCA-1 is a 605 amino acid protein that localizes to the cytoplasm and the cytoskeleton, as well as to cytoplasmic vesicles and the cell membrane, and contains one FCH domain, one REM repeat and one SH3 domain. Existing as multiple alternatively spliced isoforms, TOCA-1 interacts with CDC42 and is required for the coordination of membrane tubulation with Actin cytoskeletal reorganization during endocytosis. Additionally, TOCA-1 is involved in membrane invagination, tubule formation and Actin polymerization. The gene encoding TOCA-1 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Synonyms C1orf39; FBP1L_HUMAN; FNBP 1L; fnbp1l; Formin binding protein 1 like; Formin-binding protein 1-like; TOCA 1; Toca-1; TOCA1; Transducer of Cdc42 dependent actin assembly 1 ; Transducer of Cdc42 dependent actin assembly protein 1; Transducer of Cdc42-dependent actin assembly protein 1. Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin. Store at 4°C for 12 months. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support at [email protected] or your distributor service.
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GWAS Meta-Analysis Reveals Novel Loci and Genetic Correlates for General Cognitive Function: a Report from the COGENT Consortium
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FNBP1L Antibody (Center) Affinity Purified Rabbit Polyclonal Antibody (Pab) Catalog # Ap16582c
10320 Camino Santa Fe, Suite G San Diego, CA 92121 Tel: 858.875.1900 Fax: 858.622.0609 FNBP1L Antibody (Center) Affinity Purified Rabbit Polyclonal Antibody (Pab) Catalog # AP16582c Specification FNBP1L Antibody (Center) - Product Information Application WB,E Primary Accession Q5T0N5 Other Accession Q2HWF0, Q8K012, NP_001157945.1, NP_001020119.1 Reactivity Human, Mouse Predicted Rat Host Rabbit Clonality Polyclonal Isotype Rabbit Ig Antigen Region 349-377 FNBP1L Antibody (Center) - Additional Information Gene ID 54874 FNBP1L Antibody (Center) (Cat. #AP16582c) western blot analysis in mouse lung tissue Other Names lysates (35ug/lane).This demonstrates the Formin-binding protein 1-like, Transducer of FNBP1L antibody detected the FNBP1L Cdc42-dependent actin assembly protein 1, protein (arrow). Toca-1, FNBP1L, C1orf39, TOCA1 Target/Specificity FNBP1L Antibody (Center) - Background This FNBP1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 349-377 amino The protein encoded by this gene binds to acids from the Central region of human both CDC42 and FNBP1L. N-WASP. This protein promotes CDC42-induced actin polymerization by Dilution activating the N-WASP-WIP complex and, WB~~1:1000 therefore, is involved in a pathway that links cell surface signals to the Format actin cytoskeleton. Purified polyclonal antibody supplied in PBS Alternative splicing results in multiple with 0.09% (W/V) sodium azide. This transcript variants antibody is purified through a protein A encoding different isoforms. column, followed by peptide affinity purification. FNBP1L Antibody (Center) - References Storage Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 Maintain refrigerated at 2-8°C for up to 2 (2010) : weeks.
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