DOCSLIB.ORG

FDA-2013-N-1524 Non USP Monographed And/Or Non FDA Approved Drug Substances

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
FDA-2013-N-1524 Non USP Monographed And/Or Non FDA Approved Drug Substances 25 February 2014 IACP Nominations on Bulk Ingredients: FDA-2013-N-1524 Non USP Monographed and/or Non FDA Approved Drug Substances CAS Dose Recognition in Bibliographies on Safety and Ingredient Name Chemical Name UNII Code Number Format Pharmacopeias Efficacy Data 2-ethylhexyl-4- 2-ethylhexyl-4- 93NOD9WBCS sunscreen phenylbenzophenone-2- phenylbenzophenone-2- carboxylic acid carboxylic acid 4-Aminopyridine 4-AP; Fampridine; 504-24-5 Reagent Federal Register 1999 Dalfampridine 5-Hydroxytryptophan (L) Oxitriptan; L-Tryptophan? 9/8/4350; 73- Powder USP 22-3 Page 1 of 1183 25 February 2014 IACP Nominations on Bulk Ingredients: FDA-2013-N-1524 Non USP Monographed and/or Non FDA Approved Drug Substances 7-Keto Dehydroepiandrosterone, 7-Keto DHEA 566-19-8 Powder Not USP Micronized 8-Methoxypsoralen 8-MOP; Methoxsalen? 298-81-7 USP if correct stuff Acacia Gum, Spray-Dried Powder Acacia Gum, Spray-Dried ? NF, FCC Powder Acacia Syrup Acacia Syrup NF Acepromazine Maleate Acepromazine Maleate 61-00-7 USP Acesulfame Potassium Acesulfame Potassium 55589-62-3 NF, FCC acetaminophen acetaminophen 362O9ITL9D USP, USPMC internal analgesic acetaminophen acetaminophen 362O9ITL9D USP, USPMC menstrual/diuretic analgesic acetaminophen acetaminophen 362O9ITL9D USP, UPSMC nighttime sleep aid acetaminophen acetaminophen 362O9ITL9D USP, USPMC overindulgence in a hangover reliever Acetaminophen Paracetamol 103-90-2 Powder USP Acetaminophen, 60 Mesh Paracetamol 103-90-2 Powder USP acetanilide acetanilide SP86R356CC Not in USPNF, FCC or USPMC internal analgesic Page 2 of 1183 25 February 2014 IACP Nominations on Bulk Ingredients: FDA-2013-N-1524 Non USP Monographed and/or Non FDA Approved Drug Substances acetaZOLAMIDE Acetazolamide 59-66-5 Tablet, Powder USP Taketomo CK, Hodding JH, Kraus DM. Pediatric Dosage Handbook. 17th ed. Hudson, OH. Lexi-Comp, Inc. 2010: 41-43. acetic acid acetic acid Q40Q9N063P NF otic acetic acid acetic acid Q40Q9N063P NF wart remover Acetic Acid, 3% (w/v) Aqueous Acetic Acid, 3% (w/v) Not USP Solution Aqueous Solution Acetic Acid, 5% (w/v) Aqueous Acetic Acid, 5% (w/v) Liquid USP has a monograph for Otic Solution Aqueous Solution Solution Acetic Acid, Glacial Acetic Acid, Glacial USP acetic acid, glacial acetic acid, glacial Q40Q9N063P USP, FCC corn/callus remover acetic acid, glacial acetic acid, glacial Q40Q9N063P USP, FCC wart remover Acetone Dimethylformaldehyde, 2- 67-64-1 Liquid USP Reagents A list for Acetone Propanone acetone acetone 1364PS73AF USP, FCC skin protectant astringent Page 3 of 1183 25 February 2014 IACP Nominations on Bulk Ingredients: FDA-2013-N-1524 Non USP Monographed and/or Non FDA Approved Drug Substances Acetone Sodium Bisulfite 2-Hydroxy-2- 540-92-1 Not USP unless by another Rowe RC, Sheskey PJ, Cook WG, Quinn ME, propanesulfonic acid, name eds. Handbook of Pharmaceutical Excipients. sodium salt 7th ed. London, UK. Pharmaceutical Press div Royal Pharmaceutical Society of Great Britain and Washington, DC. American Pharmacists Association; 2012. Acetyl glucosamine Glucosamine Hydrochloride? 66-84-2? USP if correct stuff Acetyl Hexapeptide-3 Acetyl Hexapeptide-3 Not USP unless by another name Acetylcysteine Acetylcysteine 616-91-1 Oral or USP Morgan DL, Borys DJ. Chapter 45. Poisoning. Inhalation In: Stone CK, Humphries RL, eds. CURRENT solution, Diagnosis & Treatment: Emergency powder Medicine. 6th ed. New York: McGraw-Hill; 2011. Acetylcysteine Acetylcysteine 616-91-1 Oral or USP Morgan DL, Borys DJ. Chapter 45. Poisoning. Inhalation In: Stone CK, Humphries RL, eds. CURRENT solution, Diagnosis & Treatment: Emergency powder Medicine. 6th ed. New York: McGraw-Hill; 2011. Acetyl-L-Carnitine Hydrochloride 2-(acetyloxy)-3-carboxy- 5080-50-2 powder Not USP unless by another N,N,N-trimethyl-, chloride, ®- name 1-propanaminiu; Acetyl-L- Carnitine Acidophilus Lactobacillus Acidophilus Lactobacillus Powder Not USP, FCC? Active Ingredient Chemical Name CAS Number UNII Code Dose Format Pharmacopeia Recognition Monograph and Sub-category Adenosine-5-triphosphate Adenosine? 58-61-7? On Negative list? USP if right disodium salt name and CAS. agar agar USP, FCC laxative bulk laxative Page 4 of 1183 25 February 2014 IACP Nominations on Bulk Ingredients: FDA-2013-N-1524 Non USP Monographed and/or Non FDA Approved Drug Substances Alanine Alanine; L-Alanine 56-41-7 USP alcloxa alcloxa 18B8O9DQA2 Not in USPNF, FCC or USPMC acne alcloxa alcloxa 18B8O9DQA2 Not in USPNF, FCC or USPMC anorectal keratolytic alcloxa alcloxa 18B8O9DQA2 Not in USPNF, FCC or USPMC antifungal Alcohol Ethanol; Ethyl Alcohol 64-17-5 Liquid USP, BP alcohol alcohol 3K9958V90M USP digestive aid alcohol alcohol 3K9958V90M USP external analgesic insect bite/sting alcohol alcohol 3K9958V90M USP external analgesic poison ivy/oak/sumac alcohol alcohol 3K9958V90M USP menstrual/diuretic alcohol alcohol 3K9958V90M USP oral heath care Page 5 of 1183 25 February 2014 IACP Nominations on Bulk Ingredients: FDA-2013-N-1524 Non USP Monographed and/or Non FDA Approved Drug Substances alcohol alcohol 3K9958V90M USP skin protectant alcohol alcohol 3K9958V90M USP skin protectant astringent alcohol alcohol 3K9958V90M USP skin protectant insect bites/stings alcohol alcohol 3K9958V90M USP skin protectant poison ivy/oak/sumac alcohol alcohol 3K9958V90M USP weight control alcohol alcohol 3K9958V90M USP mercury alcohol, ethoxylated alkyl alcohol, ethoxylated alkyl 3K9958V90M external analgesic insect bite/sting alcohol, ethoxylated alkyl alcohol, ethoxylated alkyl 3K9958V90M skin protectant insect bites/stings aldioxa aldioxa 8T66I31YNK Not in USPNF, FCC or USPMC skin protectant diaper rash Aldosterone Aldosterone Not USP Page 6 of 1183 25 February 2014 IACP Nominations on Bulk Ingredients: FDA-2013-N-1524 Non USP Monographed and/or Non FDA Approved Drug Substances alfalfa alfalfa SQI2NBY9KR Not in USPNF, FCC or USPMC weight control alfalfa leaves alfalfa leaves SQI2NBY9KR Not in USPNF, FCC or USPMC menstrual/diuretic alginic acid alginic acid 8C3Z4148WZ NF weight control Aliphatic Polyesters Numerous: Poly(DL-lactide- Not USP unless by another Rowe RC, Sheskey PJ, Cook WG, Quinn ME, co-glycolide)(100:0), (85:15), name eds. Handbook of Pharmaceutical Excipients. 975:25), (65:35), and 7th ed. London, UK. Pharmaceutical Press div Numerous at (50:50); Poly(L- Royal Pharmaceutical Society of Great Britain lactide), Poly(glycolide), Poly- and Washington, DC. American Pharmacists e-caprolactone Association; 2012. Alitame Aclame; L-aspartyl-D-alanine-80863-62-3 USP Rowe RC, Sheskey PJ, Cook WG, Quinn ME, N-(2,2,4,4- (anhydrous) eds. Handbook of Pharmaceutical Excipients. tetramethylthietan-3-yl)a- and 99016-42- 7th ed. London, UK. Pharmaceutical Press div mide; 3-(L-aspartyl-D- 9 (hydrate) Royal Pharmaceutical Society of Great Britain alaninamido)-2,2,4,4- and Washington, DC. American Pharmacists tetramethylthietane Association; 2012. alkyl dimethyl amine oxide and alkyl dimethyl amine oxide gingivitis/plaque aklyl dimethyl glycine and aklyl dimethyl glycine alkyl isoquinolinium bromide alkyl isoquinolinium bromide acne Page 7 of 1183 25 February 2014 IACP Nominations on Bulk Ingredients: FDA-2013-N-1524 Non USP Monographed and/or Non FDA Approved Drug Substances Allantoin Allantoin 97-59-6 USP allantoin allantoin 344S277G0Z USP dandruff analgesic allantoin allantoin 344S277G0Z USP external analgesic allantoin allantoin 344S277G0Z USP skin protectant allantoin (5-ureidohydantoin) allantoin (5- 344S277G0Z USP corn/callus remover ureidohydantoin) allantoin (with a minobenzoin allantoin (with a 344S277G0Z sunscreen acid) minobenzoin acid) allantoin (wound healing claims allantoin (wound healing 344S277G0Z USP skin protectant only) claims only) Allithiamine Thiamine Hydrochloride? 67-03-8? USP if correct stuff Allopurinol Allopurinol Taketomo CK, Hodding JH, Kraus DM. Pediatric Dosage Handbook. 17th ed. Hudson, Ohio. Lexi-Comp, Inc. 2010: 66-67. Page 8 of 1183 25 February 2014 IACP Nominations on Bulk Ingredients: FDA-2013-N-1524 Non USP Monographed and/or Non FDA Approved Drug Substances allyl isothiocyanate allyl isothiocyanate BN34FX42G3 cough/cold nasal decongestant allyl isothiocyanate allyl isothiocyanate BN34FX42G3 external analgesic counterirritant pending allyl isothiocyanate allyl isothiocyanate BN34FX42G3 external analgesic fever blister/cold sore almadrate sulfate almadrate sulfate 9104833TPA Not in USPNF, FCC or USPMC digestive aid antacid Almond Oil Almond Oil 8007-69-0 Oil USP aloe ingredients (aloe, aloe aloe ingredients (aloe, aloe V5VD430YW9, Not in USPNF, FCC or USPMC laxative stimulant laxative extract, aloe flower extract) extract, aloe flower extract) ZY8 Aloe Vera Aloe Vera Powder Not USP unless by another name aloe vera [see aloe} aloe vera [see aloe} 09TD8L5SQV Not in USPNF, FCC or USPMC gingivitis/plaque Aloe Vera Gel Extract Aloe Vera Gel Extract 85507-69-3 Gel Extract, Not USP unless by another 200:1 name aloes aloes V5VD430YW9 USP menstrual/diuretic aloin aloin W41H6S09F4 Not in USPNF, FCC or USPMC laxative stimulant laxative Page 9 of 1183 25 February 2014 IACP Nominations on Bulk Ingredients: FDA-2013-N-1524 Non USP Monographed and/or Non FDA Approved Drug Substances alpha Ketoglutaric acid alpha Ketoglutaric acid Not USP Alpha Tocopherol Alpha Tocopherol 10191-41-0 USP Alpha Tocopheryl Acetate Alpha Tocopheryl Acetate 7695-91-2 USP alum, ammonium alum, ammonium DPU64XYB1D USP oral health care astringent alum, ammonium alum, ammonium DPU64XYB1D USP skin protectant astringent alum, potassium alum, potassium 1L24V9R23S USP antifungal alum, potassium alum,
Load more

  1183
Copy Link
Recommended publications
  • Pdf; Chi 2015 DPP Air in Cars.Pdf; Dodson 2014 DPP Dust CA.Pdf; Kasper-Sonnenberg 2014 Phth Metabolites.Pdf; EU Cosmetics Regs 2009.Pdf
    Bouge, Cathy (ECY) From: Nancy Uding <[email protected]> Sent: Friday, January 13, 2017 10:24 AM To: Steward, Kara (ECY) Cc: Erika Schreder Subject: Comments re. 2016 CSPA Rule Update - DPP Attachments: DPP 131-18-0 exposure.pdf; Chi 2015 DPP air in cars.pdf; Dodson 2014 DPP dust CA.pdf; Kasper-Sonnenberg 2014 phth metabolites.pdf; EU Cosmetics Regs 2009.pdf Please accept these comments from Toxic-Free Future concerning the exposure potential of DPP for consideration during the 2016 CSPA Rule update. Regards, Nancy Uding -- Nancy Uding Grants & Research Specialist Toxic-Free Future 206-632-1545 ext.123 http://toxicfreefuture.org 1 JES-00888; No of Pages 9 JOURNAL OF ENVIRONMENTAL SCIENCES XX (2016) XXX– XXX Available online at www.sciencedirect.com ScienceDirect www.elsevier.com/locate/jes Determination of 15 phthalate esters in air by gas-phase and particle-phase simultaneous sampling Chenchen Chi1, Meng Xia1, Chen Zhou1, Xueqing Wang1,2, Mili Weng1,3, Xueyou Shen1,4,⁎ 1. College of Environmental & Resource Sciences, Zhejiang University, Hangzhou 310058, China 2. Zhejiang National Radiation Environmental Technology Co., Ltd., Hangzhou 310011, China 3. School of Environmental and Resource Sciences, Zhejiang Agriculture and Forestry University, Hangzhou 310058, China 4. Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Hangzhou 310058, China ARTICLE INFO ABSTRACT Article history: Based on previous research, the sampling and analysis methods for phthalate esters (PAEs) Received 24 December 2015 were improved by increasing the sampling flow of indoor air from 1 to 4 L/min, shortening the Revised 14 January 2016 sampling duration from 8 to 2 hr.
    [Show full text]
  • REGULATION (EC) No 1223/2009 of the EUROPEAN PARLIAMENT and of the COUNCIL of 30 November 2009 on Cosmetic Products (Recast) (Text with EEA Relevance)
    9002.21.22 NE Official Journal of the European Union L 342/59 REGULATION (EC) No 1223/2009 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 30 November 2009 on cosmetic products (recast) (Text with EEA relevance) THE EUROPEAN PARLIAMENT AND THE COUNCIL OF THE EURO­ (5) The environmental concerns that substances used in cos­ PEAN UNION, metic products may raise are considered through the appli­ cation of Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 con­ Having regard to the Treaty establishing the European Commu­ cerning the Registration, Evaluation, Authorisation and nity, and in particular Article 95 thereof, Restriction of Chemicals (REACH) and establishing a Euro­ pean Chemicals Agency (4), which enables the assessment of environmental safety in a cross-sectoral manner. Having regard to the proposal from the Commission, Having regard to the opinion of the European Economic and (6) This Regulation relates only to cosmetic products and not Social Committee (1), to medicinal products, medical devices or biocidal prod­ ucts. The delimitation follows in particular from the detailed definition of cosmetic products, which refers both Acting in accordance with the procedure laid down in Article 251 to their areas of application and to the purposes of their of the Treaty (2), use. Whereas: (7) The assessment of whether a product is a cosmetic prod­ uct has to be made on the basis of a case-by-case assess­ ment, taking into account all characteristics of the product. (1) Council Directive 76/768/EEC of 27 July 1976 on the Cosmetic products may include creams, emulsions, lotions, approximation of the laws of the Member States relating to gels and oils for the skin, face masks, tinted bases (liquids, cosmetic products (3) has been significantly amended on pastes, powders), make-up powders, after-bath powders, several occasions.
    [Show full text]
  • 2012/054071 Al
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date ft 26 April 2012 (26.04.2012) 2012/054071 Al (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 45/00 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, (21) International Application Number: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, PCT/US20 11/001742 DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, 12 October 201 1 (12.10.201 1) KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (25) Filing Language: English NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, (26) Publication Language: English RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, (30) Priority Data: ZM, ZW. 12/925,464 23 October 2010 (23.10.2010) US 13/233,012 14 September 201 1 (14.09.201 1) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (72) Inventors; and GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, (71) Applicants : SCHLESSINGER, MD, Joel [US/US]; UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, 632 N.
    [Show full text]
  • Investigation of Agonistic and Antagonistic Endocrine Activity During Full-Scale Ozonation of Waste Water
    Investigation of agonistic and antagonistic endocrine activity during full-scale ozonation of waste water Dissertation zur Erlangung des akademischen Grades eines Doktors der Naturwissenschaften – Dr. rer. nat. – vorgelegt von Fabian Itzel geboren in Moers Fakultät für Chemie der Universität Duisburg-Essen 2018 Die vorliegende Arbeit wurde im Zeitraum von September 2014 bis September 2018 im Arbeitskreis von Prof. Dr. Torsten C. Schmidt in der Fakultät für Chemie im Bereich Instrumentelle Analytische Chemie der Universität Duisburg-Essen durchgeführt. Tag der Disputation: 21.02.2019 Gutachter: Prof. Dr. Torsten C. Schmidt Prof. Dr. Elke Dopp Vorsitzender: Prof. Dr. Bettina Siebers I Summary The use of a wide variety of chemicals in our society, such as industrial chemicals, pharmaceuticals, personal care products, etc., leads to pollution of surface waters. Especially in densely populated urban areas such as the Ruhr catchment, sustainable water management poses a major challenge. Despite intensive use through various types of discharges (effluents of direct dischargers, municipal waste water treatment plants, industry, etc.), good water quality has always to be guaranteed in accordance to the European Water Framewor Directive. Endocrine disrupting chemicals can have an effect on aquatic organisms even at very low concentrations (pg/L range). In order to reduce the emission, ozonation was investigated as advanced waste water treatment for the elimination of organic trace compounds. An elimination performance of ≥ 80% for selected substances at specific ozone doses in the range of zspec. = 0.3 - 0.7 mgO3/mgDOC was achieved. Since 2015, estrogens are listed on the watch-list of the European Water Framework Directive with required detection limits in the pg/L range.
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 8,158,152 B2 Palepu (45) Date of Patent: Apr
    US008158152B2 (12) United States Patent (10) Patent No.: US 8,158,152 B2 Palepu (45) Date of Patent: Apr. 17, 2012 (54) LYOPHILIZATION PROCESS AND 6,884,422 B1 4/2005 Liu et al. PRODUCTS OBTANED THEREBY 6,900, 184 B2 5/2005 Cohen et al. 2002fOO 10357 A1 1/2002 Stogniew etal. 2002/009 1270 A1 7, 2002 Wu et al. (75) Inventor: Nageswara R. Palepu. Mill Creek, WA 2002/0143038 A1 10/2002 Bandyopadhyay et al. (US) 2002fO155097 A1 10, 2002 Te 2003, OO68416 A1 4/2003 Burgess et al. 2003/0077321 A1 4/2003 Kiel et al. (73) Assignee: SciDose LLC, Amherst, MA (US) 2003, OO82236 A1 5/2003 Mathiowitz et al. 2003/0096378 A1 5/2003 Qiu et al. (*) Notice: Subject to any disclaimer, the term of this 2003/OO96797 A1 5/2003 Stogniew et al. patent is extended or adjusted under 35 2003.01.1331.6 A1 6/2003 Kaisheva et al. U.S.C. 154(b) by 1560 days. 2003. O191157 A1 10, 2003 Doen 2003/0202978 A1 10, 2003 Maa et al. 2003/0211042 A1 11/2003 Evans (21) Appl. No.: 11/282,507 2003/0229027 A1 12/2003 Eissens et al. 2004.0005351 A1 1/2004 Kwon (22) Filed: Nov. 18, 2005 2004/0042971 A1 3/2004 Truong-Le et al. 2004/0042972 A1 3/2004 Truong-Le et al. (65) Prior Publication Data 2004.0043042 A1 3/2004 Johnson et al. 2004/OO57927 A1 3/2004 Warne et al. US 2007/O116729 A1 May 24, 2007 2004, OO63792 A1 4/2004 Khera et al.
    [Show full text]
  • Estudo Dos Extratos Apolares De Dichotomaria Marginata, Acanthophora Spicifera, Cladophora Prolifera, Lobophora Variegata; Identificação De Sesquiterpenos
    Angelica Nunes Garcia Macroalgas e poluentes marinhos: estudo dos extratos apolares de Dichotomaria marginata, Acanthophora spicifera, Cladophora prolifera, Lobophora variegata; identificação de sesquiterpenos em Dictyopteris delicatula Tese apresentada ao Instituto de Botânica da Secretaria do Meio Ambiente, como parte dos requisitos exigidos para a obtenção do título de DOUTOR em BIODIVERSIDADE VEGETAL E MEIO AMBIENTE, na Área de Concentração de Plantas Avasculares e Fungos em Análises Ambientais. São Paulo 2019 Angelica Nunes Garcia Macroalgas e poluentes marinhos: estudo dos extratos apolares de Dichotomaria marginata, Acanthophora spicifera, Cladophora prolifera, Lobophora variegata; identificação de sesquiterpenos em Dictyopteris delicatula Tese apresentada ao Instituto de Botânica da Secretaria do Meio Ambiente, como parte dos requisitos exigidos para a obtenção do título de DOUTOR em BIODIVERSIDADE VEGETAL E MEIO AMBIENTE, na Área de Concentração de Plantas Avasculares e Fungos em Análises Ambientais. Orientadora: Dra. Luciana Retz de Carvalho Ficha Catalográfica elaborada pelo NÚCLEO DE BIBLIOTECA E MEMÓRIA Garcia, Angelica Nunes G215m Macroalgas e poluentes marinhos: estudo dos extratos apolares de Dichotomaria marginata, Acanthophora spicifera, Cladophora prolifera, Lobophora variegata; identificação de sesquiterpenos em Dictyopteris deliculata / Angelica Nunes Garcia -- São Paulo, 2019. 171p.; il. Tese (Doutorado) -- Instituto de Botânica da Secretaria de Infraestrutura e Meio Ambiente, 2019. Bibliografia. 1. Bioindicadores de poluição. 2. Contaminantes aquáticos. 3. Metabolitos algais. I. Título. CDU: 582.26 Dedico este trabalho, em especial, ao meu filho Augusto, por ser uma fonte de inspiração e alegria, aos meus pais Roberto e Sonia e ao meu marido Rodrigo. O motivo pelo qual a vida acadêmica é tão atrativa é porque se resume em 99% de árduo trabalho e de somente 1% de mágica purpurina; mas esse 1% é muuuuito bommm!!!! “Autor desconhecido” AGRADECIMENTOS Agradeço em especial à minha orientadora-amiga Dra.
    [Show full text]
  • Towards Single System for Total Water Analysis. LC-MS/MS Screening of 325 PPCP Contaminants in Tap and Surface Water
    ThP082 Towards Single System for Total Water Analysis. LC-MS/MS screening of 325 PPCP Contaminants in Tap and Surface Water. Aurore JAFFUEL1, Mikael LEVI1, Jun WATANABE1. 1 SHIMADZU Corporation, MS Business Unit, Kyoto, Japan. PPCP compounds of Surface Water best LOQ in [50-100] ppt. 1. Overview 4.1. Best Low Limits of Quantification (LLOQ). 10,11-Dihydrocarbamazepine Ceftriaxone Etoposide Oxolinic acid 4-Hydroxy Diclofenac Chlorhexidine Fosamprenavir Oxytetracycline Low limits of quantification (LLOQ) were evaluated and selected from the best Allopurinol Cytarabine Maduramicin Prednisolone Single system LC-MS/MS multi-method approach for the development of an Azelnipidine Esmolol Methylparaben Rifampicine easy access automated exhaustive water analysis tool. analytical condition for each compound. In Tap Water: 6% of the compounds Doxycycline Ethylparaben Norfloxacine Triclosan presented a LLOQ within 50-100ppt (ng/L), 18% within 3-30ppt and 71% had a PPCP compounds of Surface Water best LOQ in [3-30] ppt. 17a-Estradiol Chlorpromazine Josamycin Pravastatine LLOQ of below or equal to 1ppt, showing the high sensitivity of the methods. From 17a-Ethinylestradiol Ciprofloxacine Ketoprofen Pristinamycin IIA 2. Introduction the 304 compounds, 95% could be analyzed by at least one of the four methods, Acetaminophen Clarithromycin Marbofloxacine Propylparaben demonstrating the wide coverage of this technique (Figure 1.). In Surface Water: Acetazolamide Clorsulon Medroxyprogesterone Ribavirin There is growing concern over the exposure of humans to their chemical waste, Acetylsulfamethoxazole Closantel Mestranol Rociletinib 6% of the compounds presented a LLOQ within 50-100ppt (ng/L), 24% within 3- Afatinib Crizotinib Metaflumizone Ronidazole flushed down everyday in the conventional wastewater network: pesticides, 30ppt and 61% below or equal to 1ppt.
    [Show full text]
  • A Abacavir Abacavirum Abakaviiri Abagovomab Abagovomabum
    A abacavir abacavirum abakaviiri abagovomab abagovomabum abagovomabi abamectin abamectinum abamektiini abametapir abametapirum abametapiiri abanoquil abanoquilum abanokiili abaperidone abaperidonum abaperidoni abarelix abarelixum abareliksi abatacept abataceptum abatasepti abciximab abciximabum absiksimabi abecarnil abecarnilum abekarniili abediterol abediterolum abediteroli abetimus abetimusum abetimuusi abexinostat abexinostatum abeksinostaatti abicipar pegol abiciparum pegolum abisipaaripegoli abiraterone abirateronum abirateroni abitesartan abitesartanum abitesartaani ablukast ablukastum ablukasti abrilumab abrilumabum abrilumabi abrineurin abrineurinum abrineuriini abunidazol abunidazolum abunidatsoli acadesine acadesinum akadesiini acamprosate acamprosatum akamprosaatti acarbose acarbosum akarboosi acebrochol acebrocholum asebrokoli aceburic acid acidum aceburicum asebuurihappo acebutolol acebutololum asebutololi acecainide acecainidum asekainidi acecarbromal acecarbromalum asekarbromaali aceclidine aceclidinum aseklidiini aceclofenac aceclofenacum aseklofenaakki acedapsone acedapsonum asedapsoni acediasulfone sodium acediasulfonum natricum asediasulfoninatrium acefluranol acefluranolum asefluranoli acefurtiamine acefurtiaminum asefurtiamiini acefylline clofibrol acefyllinum clofibrolum asefylliiniklofibroli acefylline piperazine acefyllinum piperazinum asefylliinipiperatsiini aceglatone aceglatonum aseglatoni aceglutamide aceglutamidum aseglutamidi acemannan acemannanum asemannaani acemetacin acemetacinum asemetasiini aceneuramic
    [Show full text]
  • Identification of Novel Simulants for Toxic Industrial Chemicals
    International Journal of Environmental Research and Public Health Review Identification of Novel Simulants for Toxic Industrial Chemicals and Chemical Warfare Agents for Human Decontamination Studies: A Systematic Review and Categorisation of Physicochemical Characteristics Thomas James * , Samuel Collins and Tim Marczylo Centre for Radiation, Chemicals and Environmental Hazards (CRCE), Public Health England, Chilton OX11 0RQ, UK; [email protected] (S.C.); [email protected] (T.M.) * Correspondence: [email protected] Abstract: Chemical simulants have long been used in human trials of mass decontamination to determine the efficacy of decontamination interventions against more toxic agents. Until now, reliance has mostly been on individual chemicals as surrogates to specific agents (e.g., methyl salicylate for sulphur mustard). A literature review was conducted to identify chemicals that had been previously tested on human volunteers and that represent diverse physicochemical characteristics in order to create a repository for chemical simulants. Of the 171 unique chemicals identified, 78 were discounted for the risk they could pose to human volunteers, 39 were deemed suitable for use, and a further 54 were considered to be possible simulants but would require further research. Suitable simulants Citation: James, T.; Collins, S.; included both solid and liquid chemicals spanning a wide range of physicochemical properties Marczylo, T. Identification of Novel including molecular weight, octanol/water partition coefficient, vapour pressure, and solubility. This Simulants for Toxic Industrial review identifies an array of potential simulants suitable for use in human volunteer decontamination Chemicals and Chemical Warfare studies and is of relevance to future studies on systemic absorption and surface decontamination.
    [Show full text]
  • Consultation Paper: International Harmonisation of Ingredient Names
    International Harmonisation of Ingredient Names (IHIN) Consultation paper Version 1.0, May 2013 Historical consultation document Therapeutic Goods Administration About the Therapeutic Goods Administration (TGA) · The Therapeutic Goods Administration (TGA) is part of the Australian Government Department of Health and Ageing, and is responsible for regulating medicines and medical devices. · The TGA administers the Therapeutic Goods Act 1989 (the Act), applying a risk management approach designed to ensure therapeutic goods supplied in Australia meet acceptable standards of quality, safety and efficacy (performance), when necessary. · The work of the TGA is based on applying scientific and clinical expertise to decision- making, to ensure that the benefits to consumers outweigh any risks associated with the use of medicines and medical devices. · The TGA relies on the public, healthcare professionals and industry to report problems with medicines or medical devices. TGA investigates reports received by it to determine any necessary regulatory action. · To report a problem with a medicine or medical device, please see the information on the TGA website <www.tga.gov.au>. Copyright © Commonwealth of Australia 2013 This work is copyright. You may reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction for any commercial purpose and retain this copyright notice and all disclaimer notices as part of that reproduction. Apart from rights to use as permitted by the Copyright Act 1968 or allowed by this copyright notice, all other rights are reserved and you are not allowed to reproduce the whole or any part of this work in any way (electronic or otherwise) without first being given specific written permission from the Commonwealth to do so.
    [Show full text]
  • Wo 2011/060099 A2
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date _ . .. _ 19 May 2011 (19.05.2011) WO 2011/060099 A2 (51) International Patent Classification: Not classified (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (21) International Application Number: AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, PCT/US2010/056272 CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, (22) International Filing Date: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, 10 November 2010 (10.1 1.2010) HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, (25) Filing Language: English ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (26) Publication Language: English NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (30) Priority Data: TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 61/259,935 10 November 2009 (10.1 1.2009) U S (84) Designated States (unless otherwise indicated, for every (71) Applicant (for all designated States except US): LABO¬ kind of regional protection available): ARIPO (BW, GH, RATORY SKIN CARE, INC. [US/US]; P.O. Box 7469, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, Tahoe City, California 96145 (US).
    [Show full text]
  • Combined Index to USP 41 and NF 36, Volumes 1–5
    Combined Index to USP 41 and NF 36 Abaca-Acety I-1 Combined Index to USP 41 and NF 36, Volumes 1–5 Page citations refer to the pages of Volumes 1, 2, 3, 4 and 5 of USP 41±NF 36. This index is repeated in its entirety in each volume. 1–2302 Volume 1 2303–4414 Volume 2 4415–5658 Volume 3 5659–6698 Volume 4 6699–8228 Volume 5 Numbers in angle brackets such as 〈421〉 refer to chapter numbers in the General Chapters section. and (salts of) chlorpheniramine, Acetate A dextromethorphan, and methyl, 5706 pseudoephedrine, oral powder Acetate buffer, 5676 Abacavir containing at least three of the TS, 5750 oral solution, 19 following, 47 Acetazolamide, 65 sulfate, 23 and (salts of) chlorpheniramine, for injection, 66 tablets, 20 dextromethorphan, and oral suspension, 68 and lamivudine tablets, 21 pseudoephedrine, oral solution tablets, 68 Abiraterone containing at least three of the Acetic acid, 5181, 5664 acetate, 24 following, 49 ammonium acetate buffer TS, 5750 acetate tablets, 26 and (salts of) chlorpheniramine, diluted, 5181, 5664, 5690 Absolute dextromethorphan, and double-normal (2 N), 5762 alcohol, 5666 pseudoephedrine, tablets containing at glacial, 69, 5664, 5697 ether, 5664 least three of the following, 51 glacial, TS, 5750, 5754 Absorbable chlorpheniramine maleate, and and hydrocortisone otic solution, 2062 dusting powder, 1457 dextromethorphan hydrobromide irrigation, 69 gelatin film, 1929 tablets, 53 metaphosphoric, TS, 5756 gelatin sponge, 1929 and codeine phosphate capsules, 55 otic solution, 70 surgical suture, 3901 and codeine phosphate
    [Show full text]