2017

HUNTSMAN CANCER INSTITUTE CANCER HUNTSMAN Report to Our Community to Our Report

R E P O R T T O O U R C O M M U N I T Y I H U N T S M A N C A N C E R I N S T I T U T E I U N I V E R S I T Y O F U T A H THE PRIMARY CHILDREN’S & FAMILIES’ CANCER RESEARCH CENTER AT HUNTSMAN CANCER INSTITUTE

OPENING SUMMER 2017, this 220,000 square-foot expansion will double HCI’s research capacity. Connected to the existing research facility via two skybridges, the new space is designed for the following:

• Study the leading causes of disease death in children: leukemia, sarcoma, and brain cancer.

• Advance our understanding of cancers that run in families.

• Accelerate the discovery of new treatments for all cancers.

• Improve long-term quality of life for cancer survivors. U.S. NEWS & WORLD REPORT BEST CANCER HOSPITALS • Provide world-class training opportunities for the next generation of cancer researchers. NATIONAL CANCER INSTITUTE- DESIGNATED COMPREHENSIVE CANCER CENTER

NATIONAL COMPREHENSIVE CANCER NETWORK MEMBER

AMERICAN COLLEGE OF SURGEONS COMMISSION ON CANCER ACCREDITED

BECKER’S HOSPITAL REVIEW 100 GREAT ONCOLOGY PROGRAMS WHY NOW? The past has shown a 200% increase in cancer survivorship. By the year 2026, an estimated 20 VIZIENT QUALITY AND million people will be diagnosed with cancer in ACCOUNTABILITY STUDY the United States. #1 IN THE NATION FOR QUALITY Cancer moves fast. We have to move faster. OUR TIME BEGAN with an empty lot and a dream full of promise, determination, and audacity.

A dream to do the impossible. Achieve the unachievable. Defeat the undefeatable.

AS JON M. HUNTSMAN SAYS, Cancer moves fast. And we have to move faster.” CONTENTS

2 FOUNDERS

LEAD EDITING AND DESIGN: Ashlee Bright 4 EVENTS Meredith Vehar Courtney Colvin Lisa Anderson

CONTRIBUTORS: Linda Aagard 14 RESEARCH HIGHLIGHTS Jacqueline Brakey Charlie Ehlert Hannah Eisenberg Adam Finkle Diane Fouts Jonathan Martinez 26 PATIENT CARE Amie Parker Jill-Ann Pearl Susan Sheehan Jill Woods PRINTING: 34 EDUCATION AND OUTREACH Printer’s, Inc.

Thank you to all who support our mission, including donors, volunteers, researchers, clinical care professionals, administrators, and Huntsman Cancer Foundation staff. 40 GIVING A special acknowledgment to our friends at the Moran Eye Center at the University of Utah for ideas that inspired APPENDICES the production of this report. HCI Director’s Cabinet 51 Internal Advisory Board 52 External Advisory Board 53 @huntsmancancerinstitute Cancer Center Program Leaders 54 Cancer Center Program Members 54 @huntsmancancerinstitute Multidisciplinary Disease Group Leaders 62 Disease Oriented Research Team Leaders 64 @huntsmancancer Donors 66 Published Research 76 www.huntsmancancer.org Clinical Care and Research Summary 80 2 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING HUNTSMAN CANCERINSTITUTEISPART OFTHEUNIVERSITY OFUTAH AND WHOLLY OWNEDBY THESTATE OFUTAH Letter fromOurFounders,JonM.andKarenHuntsman This research expansionwill allow ustofocus Families’ CancerResearch CenteratHCI. ofthePrimaryconstruction Children’s and As we writethisletter, we are closeto completing contribute theirexpertise. researchers from allover theworldhave cometo the patientcare capacity. From thebeginning, addition wasbuiltandopenedin2011todouble HCI. Thehospitalcensusgrew soquicklythatan the region andbeyond have comefortreatment at patients. From the outset,peoplefrom throughout equipment andtechnologiesavailable for cancer hope whilealsoofferingthemoststate-of-theart rooms, inspiringspacesthatconnotebeautyand specialty hospital.It features private patient In 2004,HCIaddedtheregion’s onlycancer hillside oftheUniversity ofUtah’s medicalcampus. moment, HCIhasstoodasabeaconofhopeonthe and outpatientclinicsopenedin1999.From that much insolittletime.Its first research laboratory It thatHCIhasaccomplishedso isextraordinary Thank you! friends andsupporters. now exceeds $1.5billion.Thank you toourdear together withalltheothergraciouscontributions, cancer care possible. Today ourfamily’s investment, and theMountain West tohave thebest deserved who shared ouroptimismandbeliefthatUtah individuals, communitygroups, andfoundations soon joinedby generous families,corporations, for others. To ourjoy andastonishment,we were one familyhopingtoeasetheburden ofcancer Institute (HCI)more than20years ago,we were WHEN WE FOUNDED WHEN WE Huntsman Cancer alleviate thesuffering caused by cancer. thankstoallwhohave helped humble andheartfelt tohelpanotherwithouthelpinghimself.”try Our compensations oflifethat nomancansincerely best whenhewrote, “It is oneofthemostbeautiful lifetime. We thinkRalph Waldo Emerson saidit Karen andIhave experiencedmanyblessingsinour helped, benefittingall. around theworld,ourresearch discoveries have and more. So whetheryou live inUtah orhalfway paraganglioma, parathyroid, neurofibromatosis, cancers suchasbreast, ovarian, colon,melanoma, world. Thesediscoveries cross of abroad spectrum for inheritedcancersthananyothercenterinthe global context,HCIhasdiscovered more genes to Grand Junction, Colorado. Moreover, inthe the Mountain West, from Lake Tahoe, Nevada, now reaches intoaffiliatehospitalsthroughout something wondrous together. HCI’s expertise give $5,$10,or$25—we have accomplished to marathoners,theindividualswhocan from thechildren whoholdlemonadestands, Thanks toallofourgenerous supporters— have donatedtohelpmakeHCIwhatitistoday. Since itsfounding,more thanonemillionpeople 220,000-square-foot expansionfinanciallypossible. donors whoare helpingtomakethis$125million, Intermountain Healthcare, andthousandsofother Christ ofLatter-daySaints, theState ofUtah, by majordonationsfrom theChurch ofJesus families even more. We are joined inthiseffort in on childhoodcancersandthatrun “ “ BELIEVE ICANDO IT,” HESAID. IT, “IVOWED TO ERADICATE ITFROM THEEARTH. AND I’MJUSTCRAZY ENOUGHTO WHEN JONHIMSELF WAS DIAGNOSEDWITHCANCER, HEDIDN’TJUSTVOWTO BEAT FATHER 21 YEARS LATER. JON WAS JUST32WHENHISMOTHER DIEDOFCANCER.THEDISEASETOOK HIS Jon M.Huntsman Jon memory. ment thatcancer, likepolio,issomedayonlyahaunting devastating diseasescanbeconquered.Itisourcommit Jonas E.Salk,MD,provedtheywerewrong.We knowthat When Iwasaboy, peoplesaidwecouldnevercure polio. is someday onlyis haunting a memory. cancer, that our is commitment It like polio, devastating conquered. diseases be can proved they were wrong. We know that never cure polio. MD, Salk, Jonas E. Iwas aboy,When said we could people

Jon Huntsman M. ” -

GEORGETOWN UNIVERSITY MEDICALCENTER F. EDWARDHEBERT SCHOOLOFMEDICINE ADJUNCT PROFESSOR OFMEDICINE ASSOCIATE DEAN FOR RESEARCHDEVELOPMENT PROFESSOR OFMEDICINE MEDICAL DIRECTORATWASHINGTON CANCERINSTITUTE Sandra M.Swain,MD MOFFITT CANCERCENTERANDRESEARCH INSTITUTE EXECUTIVE VICEPRESIDENT DISTINGUISHED MOFFITTSCHOLAR CENTER DIRECTOR Thomas Sellers,PhD,MPH DANA-FARBER CANCERINSTITUTE PROFESSOR OFMEDICALONCOLOGY HARVARD T.H.CHANSCHOOLOFPUBLICHEALTH PROFESSOR OFEPIDEMIOLOGY Timothy R.Rebbeck,PhD CANCER CENTER THE UNIVERSITYOFTEXASMDANDERSON FOR EARLYPREVENTIONOFCANCER BOONE PICKENSDISTINGUISHEDCHAIR PREVENTION ANDPOPULATIONSCIENCES VICE PRESIDENTANDDIVISIONCHIEFFORCANCER Ernest T.Hawk,MD,MPH THE ROCKEFELLERUNIVERSITY INVESTIGATOR ATHOWARDHUGHESMEDICALINSTITUTE MAMMALIAN CELLBIOLOGYANDDEVELOPMENT REBECCA C.LANCEFIELDPROFESSOROF Elaine Fuchs,PhD UNIVERSITY OFCALIFORNIAATLOSANGELES JONSSON COMPREHENSIVECANCERCENTER DEPUTY DIRECTOROFADMINISTRATIONANDPLANNING Rob DuWors,MPA OREGON HEALTHANDSCIENCEUNIVERSITY INVESTIGATOR ATHOWARDHUGHESMEDICALINSTITUTE JELD-WEN CHAIROFLEUKEMIARESEARCH OHSU SCHOOLOFMEDICINE ASSOCIATE DEANFORONCOLOGY DIRECTOR OFKNIGHTCANCERCENTER Brian Druker,MD THE OHIOSTATEUNIVERSITY FOUNDATION CHAIRINCANCERRESEARCH JL MARAKASNATIONWIDEINSURANCEENTERPRISE SOLOVE RESEARCHCENTER CEO OFTHEJAMESCANCERHOSPITALAND COMPREHENSIVE CANCERCENTER DIRECTOR OFTHEOHIOSTATEUNIVERSITY Michael Caligiuri,MD BIOLOGICAL STUDIES PRESIDENT OFTHESALKINSTITUTEFOR IRWIN M.JACOBSPRESIDENTIALCHAIR NOBEL LAUREATE Elizabeth Blackburn,PhD HARVARD MEDICALSCHOOL PROFESSOR OFPEDIATRICS,GENETICS PROFESSOR OFMEDICINE RICHARD ANDSUSANSMITHDISTINGUISHED DANA-FARBER CANCERINSTITUTE PRESIDENT ANDCEOEMERITUS Edward Benz,MD EXTERNALBOARD ADVISORY

3 FOUNDERS # FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING “I THINK WE CANDOTHAT. ANDTHATMEANS THOUSANDS OFLIVESSAVED ANDMILLIONSOF LIVESAFFECTED.” WITHIN FIVEYEARS WHATWOULDOTHERWISETAKE US10TO15YEARSDO,”SAID VICEPRESIDENTJOEBIDENDURING HISVISITTOHCI. “THIS ISABOUTAGGREGATING THEINTELLECTUAL, MORAL,EMOTIONAL,SCIENTIFIC, ANDCAPITALELEMENTSINTHIS COUNTRY The WhiteHouseLookstoUtahintheCancer“Moonshot”Mission TO DO DO treating, preventing, andcuring cancer. to findsolutions toaccelerateprogress toward with researchers andphysicians.Thegoalis cancer institutestolearn from and collaborate tour duringwhichhetraveled toselect U.S. The Vice President’s ofanational visitwaspart intheroundtable. also participated physicians, researchers, inthefield andexperts Senator Orrinand Hatch. Localcancersurvivors Sciences Vivian Lee,MD,PhD, MBA,and Care CEOandseniorvicepresident forHealth Beckerle, PhD, University ofUtah Health M. Huntsman, HCICEOanddirector Mary Cancer Foundation board chair Governor Jon roundtable discussioncomprisingHuntsman Population ina Database, andparticipated facility, wasgiven aninsidelookattheUtah his visit, Vice President Biden toured the Obama’s cancer“moonshot” initiative. During Vice President Joe Biden of President asapart Institute (HCI)hadthehonorofhosting ON FEBRUARY 26,2016,HuntsmanFEBRUARY Cancer ON you fordoingthat,and we’re here tohelp.” Governor Huntsman saidtoBiden. “We applaud you inyour questtofindingacure forcancer,” Americanisbehind have beenputaside,andevery Independents transformedinthissession.Politics “I’ve seenDemocrats, Republicans, and throughout thecountry. of excellence created inUtah can bereplicated desire tofigure outhow thisandothermodels statistics. Vice President Biden expressed a linked togenealogies,healthrecords, andvital in theworld,withmore than22millionrecords Population Database, thelargestgeneticdatabase Mountain West. HCIalsomanagesthe Utah Comprehensive CancerCenterinthefive-state (NCI) andistheonlyNCI-designated designation by theNational CancerInstitute HCI holdsComprehensive CancerCenter accelerate progress.” the informationwe are gathering,we canreally together andeffectively leverage andharness to cure cancer,” Beckerle said.“If we canwork looking tousasavaluable resource inthisfight Institute asoneofthebestinnationandis administration hasrecognized Huntsman Cancer President Biden andtheentire White House “We are thrilled andhonored that Vice Huntsman. we dohere unique.” istruly “What able toaccesscancertreatment,” saidGovernor wouldnotbe minority groups whootherwise have Native Americans,veterans, andother outreach.institute withthiskindofrural We York City, butit’s rare thatyou gotoacancer “You cangotoPhiladelphia, you cangotoNew andfrontier cancercare. ofrural the importance the power oftheUtah Population Database, and research: thepower ofcommunitycollaboration, totheprogressas chieflyimportant ofcancer an understandingofthree thingsthatheviews wouldwalkawaywithsaid hehopedeveryone During thediscussion,Governor Huntsman 5 EVENTS 6 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING VICE PRESIDENTJOEBIDEN,MARY BECKERLE,PHD, AND JILL BIDEN,PHD, AT THEWHITEHOUSE Utah’s RoleintheNationalCancer MoonshotContinues Ribbon Panel recommendations were presented inSeptember 2016. members ofBlue RibbonPanel working groups. The results ofthe Blue Mooney, PhD, distinguishedprofessor ofnursing, were as invitedtoserve investigators, Martin McMahon, PhD, professor ofdermatology, andKathleen in precision prevention andearlydetectionofcancer. Two otherHCI Beckerle waschosentoco-chairaworking group dedicatedtostrategies onthisdistinguished26-memberpanel. was invitedtoserve Huntsman CancerInstitute (HCI)CEOanddirector, Beckerle, Mary PhD, for cancerresearch prioritiestohelpacceleratetheprogress againstcancer. initiative wasformed.Thisgroup wastaskedwithmaking recommendations IN APRIL 2016, APRIL IN Population Sciences atHCIand distinguished professor ofnursing,were inattendance. Cancer Foundation, andKathleenMooney, PhD,RN,co-leaderof CancerControland University in Washington, DC,where SusanSheehan,president andCOOofHuntsman regional summitattheUniversity ofUtah.TheVice PresidenthostedagroupatHoward the nextfiveyears—and to ultimatelyendcancerasweknowit.HCIhosted anofficial ways ofspeedingupprogress incancerprevention,diagnosis,treatment,and careover researchers, physicians, advocates, philanthropists,andtechnologyexperts tobrainstorm Cancer MoonshotsummitsJune29,2016.Thesebrought togetherpatientsandsurvivors, Organized attherequestofVice PresidentJoeBiden,morethan270organizationshosted a National Blue RibbonPanel onthe CancerMoonshot SAMIR COURDY, MBA, AND RACHEL HESS,MD JOHN SWEETENHAM, MD,MIKAELA LARSON, PANELISTS AT HCI’SMOONSHOTSUMMIT

7 EVENTS 8 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING Hosting HonoredGuests human values andinnerhappiness.” harmony asheshared histhoughtsonteaching of His Holiness andtophysically feelpeaceand said, “It wasmy pleasure tobe inthepresence Emma Houston, anHCIbreast cancersurvivor, physicians, staff,several patients,andcaregivers. Cancer LearningCenter, where hemetwithHCI Holiness totheG.Mitchell wasescorted Morris time totalkwithpatientsandloved ones,His Holiness whenhearrived atHCI.Aftertaking and deanoftheSchoolMedicine, greeted His Care, seniorvicepresident forHealth Sciences, Vivian Lee,CEOofUniversity ofUtah Health University ofUtah president David Pershing; and Beckerle,Mary PhD, HCI’s CEOand director; universal responsibility. Center, where hespokeaboutcompassionand afternoon attheUniversity’s Jon M.Huntsman The occasioncoincidedwithanevent laterthat University ofUtah duringavisitJune 21,2016. Huntsman CancerInstitute (HCI)andthe of Tibet metwithpatientsandleaders of HIS HOLINESS THE 14TH LAMA DALAI

“ promote a sense of concern for others. others. for a sensepromote of concern and human beings other Serve and oneness. To globally to is minded have be asense of unity His Holiness the Dalai Lama the Dalai Holiness His SPEAKING AT THE UNIVERSITY OFUTAH JUNE 21,2016 ” Humanities Centerco-hostedtheevent. School ofMedicine, andtheUniversity ofUtah Tanner from avariety ofbackgrounds duringhisvisit.HCI,the and acancersurvivor, and spent timemeetingwithstudents inapaneldiscussionat HCIwithscientistsparticipated 2016. Mukherjee provided apubliclecture oncampus, A Biography ofCancer, visitedHCIonMarch 23, prize winningauthorofThe Emperor of All Maladies: SIDDHARTHA MUKHERJEE, MD, PHD, Pulitzer- 9 EVENTS 10 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING “ THE UNIVERSITY OFUTAH AND HCIHONOREDTHEHUNTSMANFAMILY AND CELEBRATED NATIONAL CANCER INSTITUTECOMPREHENSIVEDESIGNATION. Joining the Top CancerCentersintheWorld strategic planforthefuture.” peer review ofourprograms, people,facilities, and such anhonorcomesonlyafterrigorous scientific our organization.It isespecially gratifyingthat designation required excellence level of atevery CEO anddirector ofHCI.“Securing this of ourcommunity,” Beckerle, said Mary PhD, of hard work anddedication by allmembers “This designationistheculminationof years highest designationpossible. Comprehensive CancerCenterstatus,the had received theNational CancerInstitute’s Utah. On July 9, 2015,HCIannouncedit Cancer Institute (HCI)attheUniversity of IT’S AN HISTORICIT’S TIME will make to the cancer patients in our state, in the region, and in the world. region, and in in our in the state, the will patients make cancer to the this to receive Comprehensive adifference What Cancer Center status. necessary nation’s of the asmallOnly percentage have programs cancer excellence the for Huntsman for among thetopcancercenters intheworld. Center, andtheMayo ClinicCancerCenter— Johns Hopkins KimmelComprehensive Cancer Farber CancerInstitute ofHarvard University, Center, MDAndersonCancerCenter, Dana- centers suchasMemorial Sloan-Kettering Cancer With thisstatus,HCIjoinsdistinguishedcancer than 17%ofthecontinentalU.S.landmass. Wyoming, Montana, Idaho, and Nevada—more Mountain West region, whichincludesUtah, by theNational CancerInstitute inthefive-state HCI istheonlycancercentertobedesignated of2014. quarter thought leadersinthefourth on-site visitby nationalcancerresearch and experts That rigorous peer includedaday-long, review Jon Huntsman M. ” MANTLE CELL NON-HODGKINLYMPHOMA. SHARED HISSTORY ABOUT BEINGDIAGNOSED WITHSTAGE III JOHN MAACK,ULTRA MARATHON RUNNER AND HCIPATIENT, EVENING’S HONOREDGUESTS. HCI PATIENTS AND THEIRLOVEDONESWERE AMONG THE

ACCESS TO MORERESEARCHFUNDING • • • • • • • • • Here arehighlightsofawardsreceived: scientists maycompeteforspecialgrants. Institute ComprehensiveCancerCenter:HCI Among thebenefitsofbeingaNationalCancer

Medicine (2015) Theresa Werner, MD, Assistant Professorof COLLABORATIVE PRECLINICAL TRIALS Ana MariaLopez,MD,ProfessorofMedicine(2016) STUDENT RESEARCHEXPERIENCES UNDERREPRESENTED HIGHSCHOOL PATHMAKER PROGRAMFOR Sunil Sharma,MD,ProfessorofMedicine(2016) THERAPEUTICS CLINICAL TRIALSNETWORK NATIONAL CANCERINSTITUTEEXPERIMENTAL Medicine (2016) Theresa Werner, MD, Assistant Professorof LEADERSHIP AWARD CANCER CLINICAL INVESTIGATOR TEAM CLINICAL TRIALSREPORTING PROGRAM Ana MariaLopez,MD,ProfessorofMedicine(2015) COMMUNITY HEALTH EDUCATORS STRENGTHENING CAPACITY THROUGH GEOGRAPHIC MANAGEMENTOF and PreventiveMedicine(2015) Mia Hashibe,PhD, Associate ProfessorofFamily CANCER INNEPAL PILOT STUDY OFHPV AND HEAD AND NECK HPV IMMUNIZATION PROGRAMSWITH A FOCUS Ana MariaLopez,MD,ProfessorofMedicine(2015) HEALTH DISPARITIES Oncological Sciences(2016) Alana Welm, PhD, Associate Professor of UTILIZING PATIENT DERIVEDXENOGRAFTS Nursing (2015) Deanna Kepka,PhD, Assistant Professorof ON HPVVACCINATION INPEDIATRIC SETTINGS

11 EVENTS 12 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING Furthering theGlobalCancerDialogue FDA Approval Was Just theBeginning.” He also presented on thetopic“HPV Vaccine: management, andcancer modelsandmechanisms. cancercarecancer genetics,rural andsymptom trainees, andlearnedaboutHCIresearch in 2016. Lowy metwithHCIfaculty, staff,and Cancer Institute (HCI)onSeptember 29, National CancerInstitute, visitedHuntsman DOUG LOWY, MD, actingdirector ofthe DOUG LOWY, MD and Metastasis Molecular DriversofCancerProgression STANFORD UNIVERSITY MONTE WINSLOW,PHD OCTOBER 26,2016 Biosynthesis toChromatinModification Enzymatic Processes:FromPhospholipid Uncovering andDrugTargetingofComplex UNIVERSITY OFPAVIA ANDREA MATTEVI,PHD OCTOBER 19,2016 the Beginning HPV Vaccine:FDAApprovalWasJust THE NATIONALCANCERINSTITUTE DOUG LOWY,MD,ACTINGDIRECTOROF SEPTEMBER 29,2016 Cancer Treatment Understanding theBiologyofLateEffects UNIVERSITY OFCALIFORNIA,LOSANGELES PATRICIA GANZ,MD APRIL 15,2016 and ChromosomeArchitecture Developmental ControlofReplicationTiming FLORIDA STATEUNIVERSITY DAVID GILBERT,PHD APRIL 1,2016 Humanities Center Health SciencesCenter,andtheTanner Co-Sponsored byHCI,theUniversityofUtah and Treatment Tackling Cancerin2016:PrecisionPrevention THE EMPEROROFALLMALADIES PULITZER-PRIZE WINNINGAUTHOROF SIDDHARTHA MUKHERJEE,MD,PHD MARCH 23,2016 Targeting Cancer’sEngines,NotItsDrivers UNIVERSITY OFCAMBRIDGE GERARD EVAN,PHD MARCH 11,2016 Department ofMedicine and HematologicMalignancies,the Co-Sponsored byHCI,theDivisionofHematology in BenignandMalignantHematology Sixth AnnualHCIHematologyReview:Advances FEBRUARY 13,2016 and TargetedNucleases and ProgressionUsingTransposonMutagenesis Functional GenomicsofOsteosarcomaDevelopment UNIVERSITY OFMINNESOTA DAVID LARGAESPADA,PHD FEBRUARY 4,2016 attracting distinguishedresearchers seminars andsymposiaeachyear, HCI hostsnumerousscientific SELECTED HCISEMINARS from aroundtheworld.

ACTION NETWORKCHAIR 2015-2016 UTAHCANCER PROFESSOR OFMEDICINE MD, FRCP,FACP John Sweetenham, AWARD, 2016 FACULTY SCHOLAR MEDICAL INSTITUTE HOWARD HUGHES SCIENCES OF ONCOLOGICAL ASSOCIATE PROFESSOR Jody Rosenblatt,PhD DIRECTORS MEMBER RESEARCH BOARDOF ASSOCIATION FOR CANCER 2014-2016 AMERICAN PROFESSOR OFBIOLOGY DISTINGUISHED Mary Beckerle,PhD SELECTED FACULTY HONORS AND ACHIEVEMENTS SCHOLAR, 2016 SUSAN G.KOMEN SCIENCES OF ONCOLOGICAL ASSOCIATE PROFESSOR Alana Welm,PhD INVESTIGATOR, 2015 MEDICAL INSTITUTE HOWARD HUGHES BIOCHEMISTRY PROFESSOR OF Jared Rutter,PhD AWARD, 2015 NIH NEWINNOVATOR OF COMMUNICATION ASSOCIATE PROFESSOR Jakob Jensen,PhD LEADERSHIP AWARD,2016 INVESTIGATOR TEAM NCI CANCERCLINICAL OF MEDICINE ASSISTANT PROFESSOR Theresa Werner,MD JAMA PAPERSIN2015 TOP 5MOSTPOPULAR ONCOLOGICAL SCIENCES PEDIATRICS AND PROFESSOR OF Joshua Schiffman,MD MELANOMA RESEARCH THE SOCIETYFOR 2015 PRESIDENTOF DERMATOLOGY PROFESSOR OF Martin McMahon,PhD

13 EVENTS 14 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING OF EWINGSARCOMA.IMAGESARCOMA CELLSCOURTESY BECKERLELAB. AND ROUND,BUTFLAT AND SPREADOUTLIKENORMAL CELLS.THETEAMHYPOTHESIZESTHISCHANGECOULDSLOWMETASTATIC SPREAD RESEARCHERS FOUNDTHEDRUGHCI2509 ALTERS THESHAPEOFCULTURED EWINGSARCOMA CANCERCELLSSOTHEY ARE NOLONGERSMALL Team Science: Advancing HCILabDiscoveriestoaClinical Trial into theclinic assoonpossible,” Dr. Sharma said. “Clinical trials give us thedatawe needtoadvance appropriate therapies research, oppositepage). Research Spotlight ofSunil Sharma, MD,HCIsenior director ofclinical in treatment ofothercancers,including endometrialandprostate (see todetermineifitmay also beeffectiveand subsequentstudiesare underway In isnow 2016,thedrug beingtestedinaclinicaltrialEwing sarcoma, metastatic spread ofEwing sarcoma. Ewing sarcoma cancercells.The researchers hypothesize thiscouldslow the The investigators alsofoundthatHCI2509alterstheshape ofcultured it ledtodecreased activityofgenesinvolved incelldivisionandgrowth. activity ofgenesinvolved instoppingorkillingabnormalcells.In addition, in thejournalClinicalCancer Research, showed HCI2509ledtoincreased targets thisprotein. In 2014additionalfindingsfrom HCIlabs,published HCI2509,whichin thejournalOncogenedrug, theyhadfoundanew In 2012,twoHuntsman CancerInstitute (HCI)investigators reported from formingorspreading. off tumorsuppressor genes—thegenesthathelpprevent cancerous cells dysfunctional protein calledEWS/FLI. Thisprotein hasbeenshown toturn sarcoma isdriven by achangeinDNAthatresults intheproduction ofa it primarilyaffectschildren and young adults.case, In nearlyevery Ewing EWING SARCOMA isadeadlybonecancer. Thoughrare, whenitoccurs

CURESEARCH TEAM the timeitisdiagnosed. because ithastypicallymetastasized,orspread,by bone cancerinchildrenandischallengingtotreat spread. Ewingsarcomaisthesecondmostcommon sarcoma thatmaydisruptthecancer’s growthand nation—to testanoveltargetedtreatmentforEwing Grand Challenges Award—one ofonlyfourinthe HCI researchersreceiveda$1.73millionCureSearch RESEARCH HIGHLIGHTS

trials support. laboratory focusedondrugdiscoveryandclinical Dr. Sharmaoverseesatranslationalresearch In additiontohisclinicalresearchefforts, advances cominginoncology.” looked underamicroscopewiththenewwaveof to fusetheideaofpathologyandhowcancer While attendingmedicalschool,Dr. Sharma“began time,” hesaid. she wasoneofonlyafewfemaledoctorsatthat physicians. Mymotherwasaninspirationtomeas “I comefromafamilywherebothparentswere Dr. Sharma’s interestinmedicinecameearlyon. clinical trialsprogram. He establishedanddirectsHCI’s extensivephaseI development andtestingofnewcancertherapies. SUNIL SHARMA,MD, SUNIL SHARMA,MD RESEARCH SPOTLIGHT isanexpertinthe 15 RESEARCH HIGHLIGHTS 16 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING Personalizing LifelongPatientCare set ofclinicaltrialsandthe newesttreatments.” 1 with theORIENnetwork ofcancercentersandmore than Sweetenham ofHCI-Total CancerCare® presidential professor incancerresearch, andco-leaderwith sciences attheUniversity ofUtah, Jon andKaren Huntsman director ofpopulationsciences,professor ofpopulationhealth specialized therapies,” saidCorneliaUlrich, PhD, HCIsenior possible forthesepatientstobeincludedinclinical trialsfor patients have thesamedefectintheirtumor, itisnotalways treatments. However, HCI sinceinsomecasesonlyafew genetic defectsandthatpatientsmaybenefitfrom targeted “It isbecomingclearthatcancersoftenhave specific co-leader ofHCI-Total CancerCare®. professor ofinternalmedicineattheUniversity ofUtah, and medical director andseniordirector ofclinicalaffairs, could doalone,” saidJohn Sweetenham, MD, patients, allowing ustodomore thananyonecancercenter we have accesstomuchmore informationfrom manymore “By joiningwithleadingcancercentersacross thecountry, physicians provide bettercare. create apersonalprofile ofthepatientthatwillhelpHCI behaviors, andqualityoflife.Theinformationisusedto asked tocompletequestionnaires aboutfamilyhistory, health tissue samples,share medicaldataforresearch, andmaybe information related totheircancerdiagnosis.Patients donate researchers treatments sotheystayapprisedofnew and withHCI’sprogram partner healthcare providers and Patients intheHCI-Total whoparticipate Cancer Care® trials andtreatment developments across thecountry. (ORIEN), usespatientdatatohelpmatchpatientsclinical the Oncology Research Information Exchange Network The program, whichisborneoutofHCI’s membershipin treatments andintogoodhealththroughout theirlives. which willfollow patientsthrough cancerscreenings and launched auniqueprogram calledHCI-Total CancerCare®, IN 2016, HUNTSMAN CANCER INSTITUTE (HCI) 50,000 participants, HCIpatientshave access toabroader50,000 participants, . “By working HCI executive

CORNELIA ULRICH,PHD,MS in Columbus, Ohio. in Columbus, Ohio. Richard J.Solove ResearchInstitute Arthur G.JamesCancerHospital and Comprehensive CancerCenter – and TheOhioStateUniversity Cancer CenterinTampa, Florida, ORIEN wasfoundedin2014 byMoffitt centers aspartoftheORIENnetwork. HCI joinsotherleadingcancer JOHN SWEETENHAM,MD,FACP, FRCP

These arethelong-rangegoalsofcancerpopulationsciences: genomics andearlydetectiontosurvivorshipend-of-lifecare. continuum, fromprevention,epidemiology, andscreeningto Population scientistsstudyareasacrossthehealthcare that canbereadilybroughttotheclinicandpopulation. cancer prevention,earlydetection,andsurvivorshipstrategies amplify theimpactoftheirwork.Theystrivetoidentifybetter They collaboratewithcolleaguesinlabsandtheclinicto Database, geneticcounseling,andotherresearchresources. HCI cancerpopulationscientistsoverseetheUtahPopulation scientists primarilyfocusonthreeareas: At HuntsmanCancerInstitute(HCI),cancerpopulation WHAT ISCANCERPOPULATION SCIENCES? • • • • • • •

affect theirwell-beingandsurvival characteristics ofcancerpatientsandhowthese Research onhealthbehaviorsandbiologic screening andprevention such aslifestyle,behavioralchoices,andappropriate Strategies thathelppeoplemanagetheircancerrisk communication ofgeneticrisks the discoveryofnewcancergenestomeaningful Studies ofcancersthatruninfamilies,rangingfrom for patientsandtheirfriendsrelatives Find strategiesthatmakethediseaseeasiertomanage patients impactedbycancer Improve qualityoflife,healthstatus,andsurvivalfor cancers areeasiesttotreat Increase cancerpreventionandearlydetectionwhen rural areas Reduce cancerdeathsinthepopulation,including

17 RESEARCH HIGHLIGHTS 18 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING Pairing Philanthropywith Top Researchto Advance CancerCures continuing thelegacy(seeletter). given by RichieandJulie Smith, and asubsequent,majorgiftwas intheSmithtrait thatruns family, University ofUtah. Generosity isa to pursuemedicalresearch atthe a giftfrom thefamilybusiness Ida,he andhissweetheart, made better treatments forbraincancer, Recognizing thedire needfor and passedawaythatsameyear. brain cancerattheageof58 entrepreneur wasdiagnosedwith and Drug Centers.Thebrilliant known todayasSmith’s Food storessuccessful chainofgrocery that modestbeginningintothe Brigham City, Utah. He parlayed store inat thefamilygrocery Dee Glen Smith beganhiscareer of thisgenerosity. The Smith familyisanexample innovativesupport research. faculty, fundlabtrainees,and used toattractandretain top by anendowed chaircanbe research. Resources provided plays inadvancing cancer role philanthropythe important ENDOWED CHAIRS JARED RUTTER,PHD

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They quietly donated $1 million to support cancer research at HCI. They quietlydonated$1milliontosupportcancerresearch atHCI. Julie, andsonsNicholas,Ryan,Scott,haddonesomething remarkable. One dayin1999,JonM.HuntsmanlearnedthatDeeSmith’s sonRichie,wife Endowed Chairfor Cancer Research in2014. research program—earned himtheDee Glen and Ida W. Smith teaching students, toadvancing hisproductive andcollaborative contributions tothecommunity—from mentoringfaculty, to Hughes Medical Institute Investigator. Dr. Rutter’s many the prestigious andhighlycompetitive recognition asaHoward andin2015received asaprofessor ofbiochemistry also serves gene regulation, cancermetabolism,andgenomestability. He investigators whostudy that coalescesthework of26laboratory Control ofCellGrowth andDifferentiation Program, agroup Utah. He isco-leaderofHuntsman CancerInstitute’s Nuclear JARED RUTTER, PHD, wears manyhatsattheUniversity of Cancer CarefromtheComfortofHome: Telehealth

Services Administration Resources Human Services, Health Source: U.S.DepartmentofHealth and communications, andmore. the Internet,streamingmedia, wireless include telephone,videoconferencing, administration. Technologies may health-related education,andhealth for long-distanceclinicalhealthcare, and telecommunicationstechnologies Telehealth useselectronicinformation KATHLEEN MOONEY, P WHATIS TELEHEALTH? H D, RN

equitable care andbetter outcomes forall. communities, enablingmorefor peoplewho live in rural Telehealth strategytoimprove isoneimportant cancercare symptoms atall.Caregivers alsoreport betteroutcomes. moderate daysreported, and more dayswithout any cancer: fewerdaysofsevere symptoms,more mild-to- The strategyhasshown dramatic results forpeoplewith help managetheperson’s needs. patient responses, care thesystemalerts providers sotheycan physically andpsychologically. Based ontheseverity ofthose with patientsdaily, askingthemtoreport onhow theyfeel This wasusedtodevelop atelehealthsystemthatchecksin algorithm basedoncommoncancersymptomsand severity. management. Building uponpastfindings,theydeveloped an She andhercolleaguesspentyears researching symptom Kathleen Mooney, PhD, RN,isaleaderinthisfield. HCI researcher anddistinguishedprofessor ofnursing needs ofpeopleimpactedby areas. cancerwholive inrural long placedapriorityonunderstandinghow tobestmeetthe Utah, Nevada, Wyoming, Montana, andIdaho, HCIhas Center inthefive-state Mountain West, anarea thatincludes As theonlyNational CancerInstitute-designated Cancer our work inremote symptommanagement. City, outofthemanyareas ofresearch strength, we showcased about theplansfor Vice President Biden’s visittoSalt Lake WHEN HUNTSMAN CANCER INSTITUTE learned

19 RESEARCH HIGHLIGHTS 20 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING MOTHER TOTALS MORETHAN30,000DESCENDANTS,27,000OFWHOM ARE STILL ALIVE AND LISTEDINTHEUPDB. ELEVEN GENERATIONS OFTHISFAMILY ARE RECORDEDINTHEUPDB(BEGINNING1807).FULL PEDIGREE ASSOCIATED WITHTHE Making Cancera Thing ofthePast Cancer Institute. is housedright here attheUniversity ofUtah’s Huntsman States suchresources andoneoffew inthe world.Andit The UPDBistheonlydatabase ofitskindinthe United and cardiac arrhythmia(KCNH2). cancer (APC),breast cancer(BRCA1), melanoma (p16), genediscoveries,important includingthoseforcolon genetic mutations.This resource contributedto patterns ofgeneticinheritance,andidentifyspecific families withanexcess incidenceofcancer, analyze Researchers have usedtheUPDBtoidentifyandstudy generations andaslongagothelate17thcentury. more than9millionpersons—somethatgoback14 using vitalrecords. It now includesinformation for the UPDBhasexpandeditsgenealogicalcoverage by Utah pioneersandtheirmodern-daydescendants. Today, Library, theUPDBcontainsgenealogiesfororiginal Started in1975withdatafrom theUtah Family History University ofUtah andIntermountain Healthcare. data. These records are linkedtopatient records from the hospitalization certificates, records, anddriver license records,genealogies, cancerregistry Utah anddeath birth that containsrecords from manysources, including is auniqueandvast computerized research resource THE UTAH POPULATION DATABASE (UPDB)

UTAH POPULATION DATABASE INFORMATION SOURCES Cancer Registry of Idaho Utah Cancer Registry Genealogies Intermountain Healthcare University of Utah HealthSciencesCenter Utah VoterRegistration Social Security DeathRecords Driver LicenseDivision InpatientDischarge, SurgeryAmbulatory ofDepartment Health Family History Library Vital Records: Death,Marriage, Divorce Birth,

PICTURED HEREWITHHCI CEO AND DIRECTOR MARY BECKERLE, PHD,GOVERNOR JONM.HUNTSMAN, AND SENATOR ORRINHATCH. DURING A VISITONFEBRUARY 26,2016,VICEPRESIDENT JOEBIDENSPOKEWITHUTAH POPULATION DATABASE DIRECTOR KENSMITH,PHD, founded in database database UTAH POPULATION DATABASE AT A GLANCE

for the public to opportunities PARTICIPATE 9 14

17 DATING TO THE TH CENTURY # RESEARCH HIGHLIGHTS 22 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING N. JEWEL SAMADDER,MD,MSC Chemoprevention: A Family’s HopeforaCancer-FreeFuture the effectit would have onthem. had acondition, butshedidn’t yet understand theirgrandfatherandmother her siblingsknew Kathy hadasimilarexperience. Askids,sheand having toundergosometesting.” rightaway,aunt havingsurgery andthenme rightaway,mom havingsurgery andthen my Rhonda said.“After that,Icanremember my “I remember mygrandmotherhavingsurgery,” remove thecolontoprevent cancer. cancer. People withFAP to often have surgery have nearly100%riskofdeveloping colon cancer. With somanypolyps, peoplewithFAP polyp intheintestinehaspotentialtobecome throughout thesmallandlargeintestines.Any FAP causeshundreds ofpolypstoform polyposis (FAP), aninheritedgeneticdisease. Kathy andRhondahave familialadenomatous (HCI) tobetestedforpolypsintheirintestines. teams. Theytravel to Huntsman Cancer Institute friends ortocheerforUniversity ofUtah sports Illinois toSalt LakeCity. It isn’t toseefamilyand regularly makethetripfrom theirsmalltown in KATHY AND HER NIECE, RHONDA, of theirfamilies. Rhondasaid,“HCIhas given not onlyfor their own health,butforthehealth inthetrial— Kathy andRhondabothtook part for bowel inpatientsatthehighestrisk. surgery are asteptoward preventing cancersandtheneed the Journal oftheAmerican Medical, Association disappeared completely. The results, publishedin in theirpolypnumbers.For some,thepolyps medication seeingagreater than70%drop results, withpatientswhoreceived the trialshowed promisingThis preliminary very chance thattheydevelop thosecancers.” small intestine,we canreduce oreliminatethe it’ssaid. “Whether cancerinthecolonor with thehighestriskofcancer,” Dr. Samadder “We cantargettheuseofamedicationtopeople polyps formingintheintestine. medicinethatreducestest anew thenumberof professor ofmedicine.He ledaclinicaltrialto of HCI’s high-riskcancerclinics andassistant they metJewel Samadder, MD,clinicaldirector genetic causeofFAP wasdiscovered. There, in geneticcancers.TheyfoundHCI,where the Family searching forspecialists membersstarted RHONDA, AUNT AND NIECE WITH A HEREDITARY COLON CANCER CONDITION. A NEWDRUGTESTEDIN A CLINICAL TRIAL BRINGSHOPETO KATHY AND Dr. Samadder. breastand hereditary andovarian cancer,” said Lynch syndrome (anothercauseofcoloncancer), prevention inhigh-riskdisorders suchasFAP, looking atchemoprevention orprecision cancer “We hopethistreatment will spurfuture trials centers nationwide. for thistreatment thatincludesseveral othercancer with theNational CancerInstitute toopenatrial trial.Currently,of thisimportant HCIisworking tobepart Kathy andRhondaflyacross thecountry Dr. Samadder saidhe’s thankfultohave peoplelike something else.They’ll keepworking.” get through withthistrial,they’ll move onto isn’t complacency,” they sheexplained.“When to endthethreat ofalltypescancer. “There and doctorsatHCIwon’t stoplookingforways Kathy agrees, addingthatsheknows theresearchers gives myfamilyhope.” children canhave children withoutthedisease.It Now thattheyknow thegeneticmarker, my me hopeformychildren andmygrandchildren. colleagues useddatafrom theUPDBinthis study. identified group ofFOPNLpatients.Camp andher finding therapiestoimprove prospects forthis newly immune response. Future studieswillfocuson marrow cellsinvolved incoordinating thebody’s medicine tothisaggressive cancerthataffectsbone the results are asteptoward applying precision Camp, PhD. Published inNature Communications, HCI investigator andprofessor ofmedicineNicola collaborative studies,we hopetoaddthis,” said it hasquitealargeeffectonsurvival. With even larger “We were abletoidentifytheFOPNLvariant because Institute (HCI)and 17otherinstitutions. study includedresearchers from Huntsman Cancer todate,the inherited geneticsandmyeloma survival to three years sooner. Thelargestcollaborationof patients withavariation inthegeneFOPNLdieone What’s more, arecent studyfoundmultiple myeloma myeloma patientsdiewithinfive years ofdiagnosis. It’s asoberingstatistic:anaverage of43%multiple from makingenoughhealthybloodcells. of thebody. Thesetumorsmaykeepthebonemarrow in thebonemarrow andformtumorsinmanybones In multiplemyeloma, abnormalplasmacellsbuildup Patients WhoFaceGrimOdds Improving OutcomesforMyeloma NICOLA CAMP, PHD # RESEARCH HIGHLIGHTS 24 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING An InheritedCancerSyndromeNoLongeraFamilyCurse and gives meabiggerdrive tofindanswers.” special connection thatmakesmemore passionate also have cancer,” Kierasaid.“IfeellikeIhave this “I hadcancer, andnow I’m helpingothers that mission. She becameacancerresearcher atHCI. Kiera’s experience withcancergave life heranew pronounced cancer-free. onherabdomen,shewas of treatment andsurgery an aggressive form ofcancer. Afterseveral months Kiera wasdiagnosedwithpleomorphicsarcoma, taking hertoHuntsman CancerInstitute (HCI). with thesamepain.Her mother, Eleana, insistedon She wassenthomebutreturned twoweeks later cancer. Themasswasdiagnosedasdiverticulitis. abdomen, theemergencydoctorsdidn’t suspect room inpainandaCTscanrevealed amassinher cancer. Still, whenKierawent totheemergency children, several ofwhomwere diagnosed with understatement. Her grandfatherwasoneof16 Saying Kiera’s ofcancerisan familyhasahistory like hersbetterunderstandarare geneticmutation. answers andisconductingresearch tohelpfamilies generations. Now years outoftreatment, Kierahas thathadloomedoverdeadly mystery herfamilyfor at age19,shefoughtnotonlysarcoma, butalsoa WHEN KIERA WAS DIAGNOSED with cancer hope toherfamily andothersdiagnosed withLFS. knowledge soshecangive aboutcancerforward, to do“the nitty-gritty research” thathelps move of Utah. Her goalistofinishschoolandcontinue Kiera isnow inaPhD program attheUniversity oncologists towatchoutfor anysignofcancer. has bloodwork taken,andmeetswithseveral cancer screenings, getsafull-bodyandbrainMRI, can takepreventive measures. She doesyearly Knowing abouthergeneticmutationmeansKiera well,” Kierasaid. to betestedandthatmydadneededas home andIshowed mymom.Itoldhersheneeded She hernextstep. knew “I brought my paperwork are theodds?” Kiera. “What of theleadinglabsinLi-Fraumeni research,” said before IwasdiagnosedwithLFSbecauseitisone “It’s crazythatIwasworking intheSchiffman Lab confirming thatshehasLFS. LFS. Two weeks later, Kiera received adiagnosis a colleague,whosuggestedKierabetestedfor Kiera mentionedherfamily’s to cancerhistory that meansanearly100%riskofcancer— Syndrome (LFS)—aninheritedgeneticmutation Schiffman LabatHCIaboutLi-Fraumeni While working onaproject intheDr. Joshua “ get to do that. to that. get do and honored blessed to very feel have I chanceto others. help the I where I was in put aposition Kiera Jorgensen Kiera ”

lifetime riskofcancer. response tocelldamage.People withLi-FraumeniSyndromearenearlytheopposite.They haveonlyonecopyof copies thanothermammals,including dogsandhumans,whichisbelievedtoprotectthem againstcancerbyheighteningthe at HCIuncoveredapossibleanswer. Itisrelatedtoagenecalled p53.Thechartaboveshowsthatelephants havedozensmore Elephants rarelygetcancer. Thereasonwhy hasstumpedscientistsfordecades.ResearchfromtheDr. JoshuaSchiffmanLab

SOURCE: SCHIFFMANLAB TMRSPRSO EE40 TP53 TUMOR SUPPRESSORGENE CANCER MOR LIFETIME RISKOFCANCER screenings tospotcancerbeforeitspreads. to betestedforLFS,andiftheyhaveit,startannual Kiera andEleananowencourageotherfamilymembers early andEleanaunderwentsuccessfultreatments. and, morerecently, breastcancer. Bothcancerswerefound screenings, whichleddoctorstodiscoverkidneycancer has Li-FraumeniSyndrome(LFS).Shebeganregularcancer Kiera’s mom,Eleana,hadgenetictestingandfoundshealso CANCER SCREENINGSCANSAVE LIVES TA LITY RATE ELEPHANT 5 0 25% 50% <5% 5 5 35%90% 33-50% 25% <5%

O VRG ESN WITHLFS AVERAGE PERSON DOG 221 p53 anda90% available LI-FRAUMENI SYNDROME not 25 RESEARCH HIGHLIGHTS 26 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING Oncology Nurses–ProvidingExceptionalPatientCare the endofmy visit.I’ll alwaysremember that.” take care ofmyhealth. Each even gave meahugat sweet andjustmademefeelliketheywantedto help “The nurseswhosawme were so, sokindand about mynurse.She kind.” isefficientand very “I hadaninfusion…Ican’t sayenoughgoodthings an exceptional patientexperience: the majorrole theirnursehadincontributingto Some recent commentsfrom ourpatientsreflect standard ofcare. Our nursesare essentialtothisexceptional conductedby Pressnationwide surveys Ganey. 99th percentile inpatientsatisfactionbasedon HCIroutinely scoresand familysupport. inthe step—from clinicvisitstotreatment towellness contribute toexcellent patientcare atevery HCI’s professionals nursesandsupport their profession. our oncologynursesare ontheleadingedgeof is known forleading-edgecancercare, and HUNTSMAN CANCER INSTITUTE (HCI) angels inheaven, they are allnurses.” Vice President Biden said, “If there are any treatments forglioblastoma. family whilehisson,Beau Biden, underwent profound impactthenurseshadon himandhis Vice President Biden conveyed toHCIwhata ofcancercare.made by nursesindelivery a conversation aboutthecriticalcontributions advance cancerresearch. Thediscussionincluded the uniquewayswe inUtah are working to joined thevicepresident inadiscussionabout HCI inFebruary 2016,anumberofpanelists During thevisitof Vice President Biden to their families. prevent, diagnose,andtreat cancerpatientsand understanding ofresearch discoveries tobetter of nursesare criticaltoourmissionadvance and bettercancertreatments. Thecontributions ofclinicalresearchalso intheirsupport onnew ofoutstandingcancercare, butonly indelivery Nurses role, not playanespeciallyimportant its fifth cohort, preparesits fifthcohort, HONRstobecome Oncology-Certified Nurses. development are aspectsoftheprogram. The rigorous alsoimportant 12-month training, which recently began The curriculumincludes anevidence-basedproject toimprove patientoutcomes. Mentorship andprofessional Residency (HONR)program nursesbesuccessful intheirfirst isdesignedto help new year incancercare. nurses inoncologydevelophelp new astrong foundationforfuture success.The Huntsman Oncology Nurse Nursing isademanding profession, andoncologynursingrequires specialized knowledge. Training iskeyto Best PracticesInform UniqueHCI Training ProgramforOncologyNurse Professionals “ my firstmentor. by myfavoritenursinginstructor, Dr. MaryBruton.Shewas This isapictureofmethedayin1979when Igot‘pinned’ ” Sue Childress Sue

HUNTSMAN CANCERINSTITUTE AT THE UNIVERSITY OFUTAH DIRECTOR OFNURSINGSERVICES Sue ChildressRN,MN,OCN ofoncologynursing.practice theart It isalsoanamazingenvironment forournursesto outstanding environment tocare forourpatients. Thanks to Jon andKaren Huntsman, HCIisan their career andpassionhave collided. It isabeautifulmomentwhenpersonrealizes on theirlives andtheirfamilies. totellmetheimpactHCInurseshave had they try asI have seenstoicmengetchokedupandtearful impacted theircancerexperienceisoverwhelming. totellmeabouthow thenursingstaffhastrying And thentheypause.Theemotioninvolved in their passionateappreciation fortheirphysicians. step aheadofme.AsIvisitpatients,oftenhear competent andcreative, andalwaysseemtobeone As agroup, oncologynursesare andkind, smart journeys theymakehasbeeninspiringandhumbling. Getting toknow ourpatientsandthedifficult lifelong friendshipsIwouldhave withcolleagues. best career Icouldhave chosen.Inever realized the was allaboutthecapanduniform!It hasbeenthe I’ve wantedtobeanursesinceIwassixyears old.It WHEN CAREER AND PASSION COLLIDE

27 PATIENT CARE 28 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING Improving QualityofLifeduringandafter Treatment Wellness andIntegrative Health Centerwasnamed mission. TheLindaB.and B.Robert Wiggins received HCI’s alargedonationtohelpfurther In 2007,Huntsman CancerInstitute (HCI) assessments, forexample,tookplaceinarestroom. work andlimitedhospitalspace—thefirstfitness exercise. Many programs beganwithvolunteer improving patientrecovery andwellness through a grassroots approach, withthepurposeof HEALTH CENTER THE WELLNESS AND INTEGRATIVE began in2005through to 20,000patientvisitsin2016. treatments, andmuchmore. Thecenterhadclose massage therapy, musictherapy, osteopathic creativeincluding art, writing,cookingclasses, andresearchmore studies, than35services grown ofHCI,now intoanessentialpart offering The Wellness and Integrative Health Centerhas some normalcy. cancer maintaintheirphysicalabilitiesandachieve were in helpingpeoplewith important services in theirhonor. Lindabelieved thesesupport Facial Prosthetics:RestoringSelf-ConfidenceandSmiles move onwithlife.” sincere thankyou afterI’ve helpedsomeone work. But themostrewarding “A part? Tanner enjoys andscienceofhis theart published inpeer-reviewed scientificjournals. Tanner contributestoskincolorstudies translucency ofskinandprosthetic materials. Research atHCIfocusesonthecolorand problems andinnovate.” needs tothinklikeascientistinorder tosolve Tanner. who “Itellpeople Iamanartist prostheses yieldsremarkable results,” said “Applying ofmaking science totheart and translucency. prosthesis precisely matchedtoskincolor with eachindividualtocreate acustom At HCI’s onsitelab, Tanner works personally including cancer. disfigurements duetoillnessandinjury, and self-confidencetopeoplewithfacial in 2004,thisprogram restores self-image Huntsman CancerInstitute (HCI).Started Tanner, who oversees FacialProstheticsat replacement, thankstoanaplastologist Paul canhave alifelikeface todiseaseorinjury PEOPLE WHO LOSE PART OF PAUL TANNER their anything,” he said. hiking androckclimbing. “I’mabletodojustabout prosthesis fitsintohisactive lifestyle,whichincludes Today Jim is cancer-free,active,andhealthy. His when Itellpeople,somecan’t tellwhichearitis.” people can’ttellIhaveaprostheticear. And even “Let meputitthisway:unlessIpointout,most Tanner. Whenaskedabouthisexperience,Jimsaid: who convincedhimtoseeanaplastologistPaul Jim metanotherpatientwithaveryrealisticprosthesis prosthesis, ornothingatall? his missingear. Shouldhehaveplasticsurgery, a He alsofacedthequestionofwhattodoabout radiation treatments,andayearofchemotherapy. surgery toremove35lymphnodes,dozensof melanoma: onesurgerytoamputatehisear, one Jim Lindowunderwentmanytreatmentsfor

PATIENT SPOTLIGHT JIM LINDOW

# PATIENT CARE 30 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING Putting BetterDiagnosticand Treatment OutcomesinView along with the analytical expertise tointerpretalong withthe analyticalexpertise data. technologies arekey role inensuringstate-of-the-art available, research andclinicaltranslationexpands,theCQCI playsa imaging rodent modelsof cancer. AsHCI’s focusonclinical withSPECT/CT andPET/MRIlaboratory scannersfor In addition,theCQCIhasestablishedapreclinical imaging flight PET/CT. time-of- PET/CT state-of-the-art, scanners,includinganew cancertherapieswithtwodedicated humanresearchin new and imagingsciences.TheCQCIintegratesHCI’s research investigator andresearch associateprofessor ofradiology imaging sciencesandneurology; andJeffrey T. Yap, PhD, Hoffman, MD,investigator andprofessor ofradiologyand at Huntsman CancerInstitute (HCI)isledby John M. The Centerfor Quantitative Cancer Imaging (CQCI) whether cancerhasspread ofthebody. tootherparts if cancerous tissuesare growing orretracting, andtoidentify noninvasive waytoevaluate theimpactofatherapy, tosee cancer. Imaging usedincancertreatment andresearch is a IMAGING IS A CRITICAL TOOL in thefightagainst “ fight againstcancer. techniques arecriticalinour and New imagingtechnologies body usingPET. actual biological functionofthe anatomy from CT, butalso the images producedshownot only combined PET/CTscanner, the glucose consumption.Using a identified asareasofincreased cancerous lesionscanbe using moreglucose.Potentially accumulates inpartsofthebody of glucosecalledFDG,which are injectedwithaspecialform cells. InPETimaging,patients glucose, orsugar, thanhealthy Cancer cellsoftenusemore John M. Hoffman, MD M.Hoffman, John ” that have animagingcomponent. ready” toconductrigorous NCItrials This recognition meansHCIis “trial- at healthytissueaswell ascancertissue. pictures oftheinsidebodytolook imaging technology—thatis,taking incancerhas demonstratedexpertise Imaging Excellence meansthatHCI named aCenterforQuantitative but whatexactlydoesitmean?Being in 2011.Aprestigious recognition, the National CancerInstitute (NCI) Quantitative Imaging Excellence by SEE. IT IS EXCELLENCE YOU CAN HCI wasnamedaCenterfor

diversity oftheproducts wesupply.” he said,“therewillonly be moregrowthand oncologists andotherresearchersincreases, in realtime,”saidBuckway. As demandfrom what ishappeninginatumorordiseasedtissue researchers tomeasureandobserveexactly “The compoundswedevelopandproduceallow HCI labsandoutsideresearchers. focus turnstoresearchcompoundsneededby Once theimagingagentsarecompleted, Yet thisisonlypartofthecyclotronteam’s day. Mountain West bygroundorair. and neighboringstateclinicsthroughoutthe are deliveredtoHCIclinics,localarea PhD, seniorPETradiochemistatHCI.Doses door around6a.m.,”saidBrandonBuckway, “Everything istestedforsafetyandoutthe into doses. HCI’s internalradiopharmacyfordispensing agent isqualitytestedandthentransferredto about 30minutesofchemicalsynthesis,the that willattachtheFlourine-18toFDG. After prepare fortheothermanufacturingprocesses it producestheFluorine-18,staffmembers the initialstepistostartupcyclotron.While When thefirstpersonwalksindooratnight, getting itsynthesizedanddelivered. rapidly withinaday, timeisoftheessencein various typesofcancers.SinceFDGdecays techniques todetect,characterize,andstage FDG. PETisoneofthemostaccurateimaging One suchagentisFluoro-2-deoxyglucose,or to manufacturePETradiopharmaceuticals. very short-livedradioisotopesthatcanbeused The cyclotronisamachinethatmanufactures Cyclotron OperationsteamatHCIgetsstarted. have longbeenclosed.Butthat’s justwhenthe The clockisnearingmidnight,andtheclinics OF A CYCLOTRONOPERATOR A DAY IN THE LIFE 31 PATIENT CARE 32 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING METASTATIC MELANOMA CELLS From Terminal toCancer-Free injected with the mutated virus, “theyinjected with themutatedvirus, started After thelesions inLarry’s armswere related proteins wherever they maybe. system tochasedown anddeactivate melanoma- releases afactorthattrainsthepatient’s immune replicates, blows upthemelanomacells,and melanoma cells.Once insidethebody, thevirus andchangeitsgenomesoitattacks onlyvirus more likeavideogame—researchers hijackthe The sciencebehindthistreatment sounds immune systemtofightcancer. example of immunotherapy: using a patient’s own cold sore inlate-stagemelanoma.Thisisan virus, laherparepvec (T-VEC), amutatedversion ofthe of multipleclinicaltrialstestingtalimogene (HCI). Dr. Andtbacka isprincipalinvestigator and investigator withHuntsman CancerInstitute Enter Robert Andtbacka,MD,CM,asurgeon as lesionsonhisarm. finished treatment, more tumorsbeganappearing MELANOMA LARRY HEGLAND’S METASTATIC wasn’t goingaway. Afterhe can now lookatcombiningthistherapywith modalityfortreatinga new melanoma,andwe some tumorsdisappeared completely. “We have 64% oftumorstreated with T-VEC shrank,and in2015,showedthe Journal ofClinicalOncology Initial results ofthePhase IIItrial,publishedin “Wow. Just wow.” scans showed hewascancer-free. His reaction? disappearing,” said.Larry’s Larry post-treatment them mylife.” at HCIby Dr. Andtbackaandhisteam.“Iowe saidhefeelsluckytohave beentreatedLarry lasting responses.” patients whorespond long- tendtohave very therapies,” addsAndtbacka, isencouraging withmanyofthese“What combination therapies. we’ve inlookingatthese beeninstrumental other therapies,” saidDr. Andtbacka.

“is thatthe

“ At HCI

PHOTO BY JULIO C. VALENCIA, COURTESY NCI CENTER FOR CANCER RESEARCH “ TAMMY WILLIS,RN,LARRY HEGLAND, AND BRITTANY THOMAS,PA-C, MPAS survival continuestoimprove. immunotherapy. Withthesestudies, 10 yearsorso,thefocuschangedto patients withmelanoma.Inthepast treatments thatimprovedsurvivalin Fifteen yearsago,wehadveryfew Robert Andtbacka, MD,CM Robert a cardthatsaid,“You’re anangeltome.” each anecklacewithanangelpendantand treatment wasfinished,Larrygavethem RN, werepartofLarry’s careteam. After his Thomas, PA-C, MPAS, andTammy Willis, angels,” saidLarryHegland.Brittany “I alwayscallTammy andBrittanymy ” 33 PATIENT CARE 34 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING Closing theHealthEquityGapforNative Americans tribal (United States), first(Canada), andaboriginal(Australia) nations’ members. The NAO Program has reached more have beenused than920,000 people. by 204Services about advocating forchange,” saidNassi. “It’s aboutempowering thepeople.” of theConfederated Tribes of Warm Springs. “Thisprogram is more thanoutreach. It’s Program administrative coordinator andisenrolled intheKlamath Tribes andadescendant Missouria Tribe andamember oftheCherokee Nation. Lynne Hall, MSW, istheNAO Phyllis Pettit Nassi, MSW, associatedirector oftheNAO Program, isenrolled intheOtoe- forging formalagreements research tosupport partnerships. (NAO) Program inJune 2008,providing culturallycompetenteducationaboutcancerand Nations, Huntsman CancerInstitute (HCI)establishedtheNative AmericanOutreach to theNational CancerInstitute. Since Utah ishometoseven Native American Tribes and ratesamongallracialand ethnic groups,year forallcancerscombined,according survival AMERICAN INDIANS AND NATIVES ALASKA LYNNE HALL AND PHYLLISPETTITNASSI “ continuetohave thepoorest five- empowering the people. people. empowering the change... advocating It’s for about about This outreach. It’s more is than program Phyllis Pettit Nassi, MSW Nassi, Pettit Phyllis Utah ishometo Tribes andNations. Native American ”

7

helped merelax.” music duringtreatments; it really after surgery. I listenedtotraditional come inanddoasmudge before and are,” saidKaren.“Ihadamedicine man doesn’t matterwhatraceorreligionyou possible tomakeyoufeelbetter. It “The medicalteamwilldoanything her culturalneedsweremet. American OutreachProgramtoensure Institute andworkedwiththeNative Karen wastreatedatHuntsmanCancer yourself andtheclansyoucomefrom). (this istheNavajowayofintroducing People, bornforTheSaltPeople Nation, KarenisofTheFolded Arms is allofthese.EnrolledintheNavajo cancer survivor:KarenBegaii-Wilson Medical technician,traditionaldancer, KAREN BEGAII-WILSON PATIENT SPOTLIGHT

and heislistedinBest Lawyers inAmerica. fellow oftheInternational Society ofBarristers, a LifeFellow ofthe Texas Bar Associationanda Southeast Texas Trial Lawyers Association.He is Lawyers Association,andpastpresident ofthe Regents, formerdirector ofthe Texas Trial member oftheLamarUniversity Board of Texas Tech University in 1974andisaformer and women.He received hislawdegree from community asachampionofworking men Wayne isknown throughout thelegal most are abletoaccessthem. theensured thatthosewhoneedcancerservices Inmedically underserved. doingso,he largest donortoHCI’s programs forthe Institute (HCI), Wayne becamethesingle Outreach Program atHuntsman Cancer After learningabouttheNative American and womentheunderserved. continue tochampioncausesforworking men Beaumont Foundation ofAmericasohecould Reaud, Morgan, andQuinn. He alsofounded than celebrateabigpayday forhislawfirm, against Big Tobacco and Toshiba, hedidmore When Wayne Reaud wonmajorlawsuits Helping theMedicallyUnderserved CANCER HOSPITAL’S SECONDFLOOR INHONOROFWAYNE REAUD. HCI NAMEDTHECENTERFOR ADVANCED THERAPEUTICS AND THE

35 EDUCATION AND OUTREACH 36 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING Forging NewPathstoCareersinCancerResearch at HCIandassociatevicepresident forHealth MD, MPH, director ofCancerHealth Equity biomedical cancerresearch. AnaMaria Lopez, piloted in2016toengagediverse studentsin The PathMaker Summer Research Program was some ofthebiggesthurdles. path tohealthprofessions forstudentswhoface increasesdepartment inclusivityandclearsthe Inclusion, andtheUniversity ofUtah biology Institute (HCI),theOfficeof Health Equityand between HuntsmanA partnership Cancer closed andsomegoalsimpossibletoconquer. obstacles, someroutes mayfeelpermanently FEAT. FORGING NEW PATHS IS NO EASY With economicandeducational Institute’s CentertoReduce CancerHealth under Lopez’s direction, from theNational Cancer PathMaker hassincebeenawarded funding, research, medicine,andhealthprofessions. research labs,andlearnedaboutcareers incancer techniques,worked inHCI learned laboratory For eightweeks duringthesummer, students university setting. professional possibilitieswhileexperiencingthe health professions tolearnmore abouttheir encourage studentsunderrepresented inthe professor ofBiology, intheDepartment to Gray,partnered withRosemary PhD, associate Equity andInclusion attheUniversity ofUtah, “ 2016 PATHMAKER PROGRAMSTUDENTS a healthprofessional.” as theybegintoexperiencethepossibilityofbeing students feel“they are onestepclosertotheirgoal The impactof PathMaker, said,isthat Lopez undergraduate students. year-round tounderrepresented high schooland offer NCICUREScholar research opportunities Experiences (CURE)program. PathMaker cannow Disparities ContinuingUmbrella ofResearch development Igrow when up. research and to work in pharmaceutical by creative coming up with solutions. Iwant I love and science and math solving problems Elizabeth Morrill Elizabeth ” underserved populations. underserved prevention andcanceroutcomesfor dedicated toimproving cancer Wetter willleadateamofscientists At theHCICenterforHOPE, Anderson CancerCenter. activity attheUniversity of Texas MD cessation, alcohol,diet,andphysical studies focusedontobaccouseand He previously ledgroundbreaking populations, minorities,andwomen. behavior inhigh-riskandunderserved leader inthestudyofhealth-related W. Wetter, PhD, aninternational University ofUtah recruited David Population Health Sciencesatthe ofHCI andtheDepartment residents andfrontier areas. ofrural including peoplelivinginpoverty and populations, among underserved waystopreventnew andtreat cancer (HOPE). Thiswillfocusondiscovering Outcomes andPopulation Equity initiative: theHCICenterforHealth Institute (HCI)announcedanew In September 2016,Huntsman Cancer New HuntsmanCenterforHOPE DAVID WETTER,PHD 37 EDUCATION AND OUTREACH 38 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING ANA MARIA LOPEZ,MD,MPH HCI LeadsRegionalCancerHealthDisparitiesProject HCI waseligible toapplyforthegrant after focused specifically oncancerhealth disparities. atHCI tocultivate cancer efforts researchers Region 6,saidtheGMaP grantisoneofthefirst Institute (HCI)andproject director forGMaP Cancer Health Equity atHuntsman Cancer Ana Maria MD,MPH, Lopez, director of cancer care nationwide. accessibleforeveryone end cancerhealthinequitiesandmakequality unique issues,butwithanoverarching goal:to program withanappreciation forgeographically matter mostintheirareas. It’s anational training, education,andoutreach topicsthat identify andprioritize thecancerresearch, Groups, collectively whichinclude152partners, specific regions throughout the United States. investigators, andcommunitymembersfrom andearly-stagetrainees andstudents,new (NCI) grant,GMaP bringstogetherresearchers, Supported through aNational CancerInstitute of CancerHealth Disparities Program (GMaP). GMaP standsfortheGeographical Management simultaneously promoting workforce diversity. expand cancerhealthequityresearch while GMAP IS DESIGNED TO ENHANCE and NV ID UT GMaP regions setouttodothefollowing: By sharinginformation,resources, andtools, addressing theseinequities,” said. Lopez of developing researchers whoare focusedon “This grantenablesustocontributeinthefield Dakota, Utah, and Wyoming. Idaho, Montana, Nevada, North Dakota, South from theNCIinJuly 2015.Region 6serves earning Comprehensive CancerCenterstatus share research andlessonslearned. 2017, bringing regional together to partners An inauguralconference willkickoffin spring pilot awards orearly-stageinvestigators. fornew andtwo$20,000development opportunities seven travel stipendsof$800eachforcareer To date,GMaP Region 6hasawarded • • • •

MT best practicesamongresearchers andtrainees Increase sharingofcancerinformationand cancer healthdisparitiesinourregion Contribute tomeasurablereductions in equity researchers underrepresented cancerandhealth Encourage the next generation of competitive Advance cancerhealthequityresearch WY HCI’s GMaP REGION ND SD they mayneed muchmore.” many needs at thebeginning,butalong theway Guadalupe. “Maybe apatientdoesn’t have as their families.“Every patientisunique,” said more than 800 Hispanichas served patientsand As of2016,HCI’s patientnavigatorprogram able toaddress theirconcerns.” We navigatorsare linguisticallyandculturally patients todrop treatment orbenon-compliant. Guadalupe Tovar. “Misunderstanding canlead is really hard forthem,” saidpatientnavigator don’t know whattodo. Theemotional impact patientsare diagnosedwithcancer,“When they concerns tocare providers. orchangestotreatmentshelp patientsunderstandinstructions andcommunicateneeds appointments where diagnosisandtreatment optionsare discussed.Patient navigatorsalso appointments, gettingorrefilling prescriptions, andaccompanyingpatientstocritical to qualitycare. Thisincludesassessingpatientandfamilyneeds,settingorchanging Launched in2009,thePatient Navigator Program goaltoeliminatebarriers hasaprimary and theirhealthcare teamthroughout treatment. asasingle,consistentpointofcontactbetween patientssystem. Thepatientnavigatorserves Spanish-speaking patientsandtheirfamiliestoguidethemthrough thecomplexhealthcare Spanish-speaking patientnavigatorsatHuntsman CancerInstitute (HCI)work with understand. There’s languageofcancertolearn. awholenew those appointments,fillingoutinsuranceforms.Thingscanbecomplicatedandhard to overwhelming—making appointmentswithmultipledoctors,planninghow toget Being diagnosedwithcancerisdifficultenough,butwhatcomesnextcanbejust as Navigating theWay throughCancer Treatment HEALTH EDUCATORS AND PATIENT NAVIGATORS LILIANA MULATO, GUADALUPETOVAR, AND ANNA MARTINEZ to the2013U.S.census. fastest growing,according 2nd largest population isthe Utah’s Hispanic/Latino and 39 EDUCATION AND OUTREACH 40 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING Embraced byBeauty our shoesas cancer patientsandcaregivers?” for otherpatients andfamilieswhowill walkin more canwe dotoimprove“What theexperience continues tothisday, thePeterson family asked, Throughout their relationship withHCI, which also becamemajordonors toHCI. ofgivingback.Their childrento theimportance Ward, MD,and introduced theiradultchildren family room inhonorofHCIoncologistJohn financial contributions,namedthehospital ways. He andhiswife,Nancy, madegenerous have shown theirgratitudetoHCIinmyriad he spenttimeasaninpatient.He andhisfamily Mark Peterson when noticedthebeautifulart up thespaceandgives itlife,” saidKaren. “Itdonated by patients,doctors,andartists. warms Curated by thecollectionwas volunteer experts, hundreds throughout ofworks thebuildings. ofart Patients, families,staff,andcare providers enjoy ofthatvision.part environment wasanimportant andbelieved art Karen Huntsman envisionedaninspirational Huntsman CancerInstitute (HCI),Jon M.and WHEN DEVELOPING PLANS for and research buildings. architecture throughout thecancerhospital heritage whileenjoying and thebeautifulart collection andcelebrate Utah’s artistic Visitors toHCIare the invitedtoview floorwaitingarea.building, andinthefourth leading from thecancerhospitaltoresearch LeConte Stewart ishoused),inthehallway a collectionofthework oflandscapeartist adjacent totheCancerLearningCenter(where first floorpharmacy area, onthesixthfloor A numberoftheseworks are featured inthe Stewart, andMahonri Young. Major, George Martin Ottinger, LeConte Huff, Alfred Lambourne,B.F. Larsen, William Culmer, John Hafen, James Frank Harwood, suchasC.C.A.Christensen,Henryartists Utahextraordinary Theseworks feature art. HCI exhibitsasignificantselectionof Nancy Peterson familyandtheP.I. Foundation, Thanks tothegenerosity ofthe V. Mark and to bedisplayed atHCIforalltoenjoy. early Utah toHuntsman art CancerFoundation, when thefamilydonateditsentire collectionof Imagine thecollective surpriseandgratitude “ minds off their troubles. troubles. their minds off socan, they take can their you beauty all the with them here. You want to embrace they or sick, wouldn’t be People are here who come ae untsman H Karen ” MARK AND NANCY PETERSON the cancerhospitalnearCancerLearningCenter. windows. Thepaintingisondisplaythesixthfloorof the paintingwasliftedbycraneandcarriedthrough elevators. Duringamajorexpansionofthecancerhospital, Lomond andFoothills,wastoomassivetofitintheHCI This 16-foot-longLeConteStewartpainting, Mt. Ben 41 GIVING 42 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING Generosity LeadsbyExample,InspiresOtherstoJointheFight others would follow theirexample. and Jodie iftheymodeled philanthropy, knew The firsttonameapatient room atHCI, Ron and theirchildren. Richardson andinhonorofhiswifeRuth Ann ofRonald Leein—is dedicatedtothememory patient room—the oneRonald actuallystayed Stadium tohonorRichardson’s memory. The at HCIaffordingofRice-Eccles view aperfect and Jodie wouldchooseaprivate patientroom It wasonlyfittingthatuponhispassing, Ron ways were awelcome distractionfrom cancer. gave himmuchtocelebrate,andtheirwinning in University ofUtah history. The Runnin’ Utes the Utes wasoneofthemostwinningseasons Utah Utes football.His last seasoncheeringfor Ronald LeeRichardson loved life,andheloved of Ronald LeeRichardson. cancerresearchdecided tohelpsupport inhonor Ron andJodie were devastated by thislossand and brother-in-law slipawaytothedisease. Ron watchedhisdearfriend,businesspartner, Having already losthisfathertocancer, in2004 Institute (HCI)isastandoutintheirminds. and nationalcommunity. But Huntsman Cancer charities inourlocalwork withmanyimportant RON AND JODIE SMART are pleasedto Ron chairs annually. have beenraisedthrough thegala andgolfevents well. Thankstotheirgenerosity, millionsofdollars they encouragefriendsand associatestodosoas first gift. Not onlydothey leadasphilanthropists, HCIeachyearhave sincethat steadfastlysupported The familyandtheircompany,Smart Won-Door, $50,000 and$150,000forcancerresearch. generous donors,eachrepresenting agiftbetween room—100 inall—hassincebeennamedby other They are private proud patient towitnessevery RUTH ANN AND THELATE RONALDLEERICHARDSON JODIE AND RONSMART Center atHCI,openingsummer2017: Primary Children’s andFamilies’ CancerResearch cancer researchthatsaveslivesthroughthe supporters whohavejoinedwithustoadvance strategies forcancer. Thankyoutoourgenerous leading tobettertreatmentsandprevention our researchcapacityandacceleratediscoveries (HCI) isnowunderway—aprojectthatwilldouble The nextphaseofHuntsmanCancerInstitute • • • • • •

Cancer Foundation than 100,000donorstothe Huntsman The JonM.Huntsmanfamily andmore The UniversityofUtah Salt LakeCounty Intermountain Healthcare The StateofUtah Latter-Day Saints The ChurchofJesusChrist

43 GIVING 44 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING Giving $10MilliontoBetheGenerationEndCancer International Fraternity Sixth Floor. the sixthfloor ofthecancerhospitalThe Sigma Chi of HCI.In honorofthiscommitment,HCInamed year, $10millionfundraisingcommitment insupport On June 15,2015,Sigma Chiannouncedaseven- cancer research atHCI. Sigma Chihasraisedmore than$4.5millionfor ofSigmasole philanthropic partner Chi. To date, Huntsman CancerFoundation wasnamedthe Constantine Sig Jon M.Huntsman. In 2013, 2005 inhonorofSignificant Sig and Order of Cancer Institute (HCI)apreferred charity in North America.Thefraternity named Huntsman the thoughtsofSigma Chimembersthroughout Sigma ChiFraternity, Michael Greenberg, echo These words from the68th Grand Consulof BELIEVE“WE THIS IS THE GENERATION TO END CANCER, AND WE BELIEVE HUNTSMAN CANCER INSTITUTE IS THE PLACE TO MAKE THIS HAPPEN.” fighting chance.” to peoplelike meandthisplacethat gave mea proud thatourfraternityhasdedicated itsefforts Chi memberandformer HCIpatient.“Iam in North America,” saidBrandon Plewe, aSigma “This gift represents across campuses hugeefforts justice, andlearning,” saidGreenberg. families, reinforcing ourvalues offriendship, Floor isahealingspaceforpatientsandtheir “The Sigma Chi International Fraternity Sixth Canada are pullingforthem.” that young peopleallaround theUnited States and patients, andcaregivers, thiswillbeareminder disease,” saidHuntsman. “To ourresearchers, is working ontheirbehalftobeatthishorrible this floorwillknow thatanentire generation “Everyone whowalksthrough ourdoorsandonto “ impossible: end cancer. might what do we seem can discouraging. But Ibelieve together and relentless be can cancer that I know experience from personal Brandon Plewe Brandon ” AND ORDEROFCONSTANTINE SIGJONM.HUNTSMAN. RAISED FORCANCERRESEARCH AT HUNTSMANCANCERINSTITUTETO SIGNIFICANTSIG ON APRIL 12,2013,SIGMA CHIMEMBERSPRESENTEDTHEONE-MILLIONTHDOLLAR YTD . . 2016 2005 2015 2010 . . . FUNDS RAISEDFOR BY SIGMA CHI . HCI $1,138,500.57 $1,160,823.11

$156,183 $39,749

together, wecanbeat thisdisease.” as moreandofuspitch in believe in,”hesaid.“Iamconfident Foundation. “Thisisagreat causeI now worksatHuntsmanCancer that gavehimsomuch,Brandon In ordertogivebacktheplace and makesmeincrediblyproud.” generation toendcancerisamazing fellow SigmaChisworkingtobethe Sigma Chichapter. “To witnessmy member oftheUniversityUtah very special,”saidBrandon,a former patientatHCIissomething “To bepartofSigma Chianda remission since2010. worked. Brandonhasbeeninfull on anaggressivetreatment,andit felt hewascurable.Theyputhim long tolive.ButBrandon’s team physicians weresurehedidn’thave such badshapethathisdiagnosing was admittedatHCI,hein with multiplemyeloma.Whenhe In 2009,Brandonwasdiagnosed family,” saidBrandonPlewe. visits IhonestlyfeellikeI’mvisiting “When IgouptoHCIformyroutine BRANDON, GRAY, KATIE, AND SIMONPLEWE PATIENT SPOTLIGHT BRANDON PLEWE 45 GIVING 46 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING Loss ofaBelovedSonInspiresGenerousPhilanthropy THE LATE GAYE MARRASH places inher career withthe State Department. the world,and live in many exotic andexciting went ontoobtainfouruniversity degrees, travel Arkansas, GayeBorn onahumblefarmin rural began toshare more life. aboutherextraordinary As Gaye’s relationship withHCIdeepened, she on discoveries. and accomplishmentsatHCIcheered herself. Eachyear, shecloselyfollowed research shewasreticentLikewise, toshare muchabout and hermotivation fordoingsobekeptquiet. For years, shepreferred thatherphilanthropy research, Marrash wasalsoaprivate woman. HCI’s mostgenerous donortosarcoma takes thelives ofchildren andyoung adults. specifically Ewing sarcoma—a lethalcancerthat gifts were directed toadvancing sarcoma research, Huntsman CancerInstitute (HCI)in2004.Her GAYE MARRASH began givinggenerously to PHILIP ALFORD

felt by patientsatHCI formanyyears tocome. Gaye passed awayin2016,buther impactwillbe in improving outcomesforthisdeadlycancer. researchers andcliniciansismakinggreat strides the strongest inthecountry, anditsteamof HCI’s sarcoma research issome of from Gaye andsomany others, Because ofgenerous support inperpetuity.memory at thehospital.It willhonorPhilip’s dedicated thePhilip Alford Stairway for decades.In 2008,withGaye’s blessing,HCI and private thatGaye couldnotopenlydiscussit away attheageofseven. Thelosswassopainful Diagnosed withEwing sarcoma, Philip passed treasure, ofhersonPhilip.heartfelt thememory to share andhonorhermostcherished, generous giftwhensheconfidedwas ready financial resources toHCI,shegave hermost herhard-earnedAnd whileshehadentrusted

“ today. today. intoall me shaped who Iam I’ve developed faith the have I’ve received, and support I’ve given, strength been the The lessons the I’ve learned, THE HEDLUNDFAMILY ” Dan Hedlund welcomed twinboystothefamily. In 2016,NoahbecameabigbrotherwhenDanandMelanie their lives.HisnameisNoahRandall—inhonorofDr. Randall. since. In2013,DanandMelaniewelcomedababyboyinto Dan hadhislastsurgeryin2012andhasbeencancer-free accepted thechallenge—anditworked. an aggressivetreatmentregimen.Dansaiditwasrough,buthe R. LorRandall,MD,directorofSarcomaServicesatHCI,chose Because ofhisageandstrongoverallhealth,Dan’s physician, osteosarcoma, arareformofbonecancer. and MelanieHedlundwereinforsomestartlingnews—Danhad Just threeweeksaftertheirweddingin2007,newlywedsDan PATIENT SPOTLIGHT DAN HEDLUND DAN HEDLUND AND R.LORRANDALL,MD 47 GIVING 48 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING Design InformedbyExperience,InspiredLove inspired beauty, serenity, inspiration, andabove need tocreate acancertreatment spacethat watched hischildslipaway, hetoofeltthe daughter wasbattlingcancer. Andasthatfather At thatsametime,atalentedarchitect’s teenage cancer specialtyhospital,theyinsistedonhope. Karen decidedtoseedtheMountain West’s only inspiring anxietybutnothope.” When Jon and and hospitalshewent towere “cold andclinical, his treatment forprostate cancer, hefelttheclinics hotel. Jon isafour-timecancersurvivor. During the cancercampusresembles abeautifulfive-star to thevisionofJon M.andKaren Huntsman that exactly theintendedimpression. Anditisthanks a hospital.It doesnotfeellikeahospital.Thatis they consistentlyremark thatitdoesnotlooklike VIEW AND FROM A FAMILY MEMBER’SPOINT OFVIEW. MANY OFTHOSEDISCUSSIONSLEDTO DETAILS THAT ARE PRESENTIN THEDESIGN.” “WE WOULDDISCUSS OUREXPERIENCES AND HOWTHENEWCANCERHOSPITAL COULDBEBETTER FROMTHEPATIENT’S POINT OF DURING DESIGN PHASES OFTHECANCERHOSPITAL, DON’SDAUGHTER UNDERWENT VARIOUS COURSES OFCANCERTREATMENTS. HUNTSMAN CANCER INSTITUTE COMEVISITORS TOWHEN (HCI), childhood cancersandfor familiesathigher at HCI.TheCenterwill advance cures for Children’s andFamilies’ CancerResearch Center tocreate thePrimary phaseisunderway fourth just 16years sinceitsfirstbuildingopened,the As we celebratethe20thyear ofitsfounding,and exceptional care. exceptional researchpossible tomarry and bestspacessight ofthevisiontocreate thevery cancer campuswe have today. Theynever lost shovel intheground tocreate thestunning dreamed, thendesigned,andputthefirst firm Architectural Nexus, and Jon andKaren Together, principalarchitect Don Finlayson, the landscapes intothepatient’s room. soothing spacesthatbrought thestunningUtah all, hope.He envisionedbeautifulvistasand

Mountain West. cancer treatment experienceinUtah and the Together, nature ofthe they changedthevery and anarchitect grievingthelossofadaughter. A philanthropist withalife-threatening disease in itschemotherapyinfusioncenter. He continuestocontributeHCIasavolunteer 20-year engagementasHCI’s principalarchitect. earned by hisfirm. He saidheisproudest ofhis an architect andalifetimeofaccoladesawards After retiring in2016,Don reflected onacareer as growing cancerinstituteintheworld. been breathtaking. Theyhave madeHCIthefastest besthaveuncompromising all insistenceforthevery discoveries ofcancerpredisposition genes,andthe the rateofbuildingfacilities,unprecedented pace ofinvestment inscienceandresearchers, risk forcancersthroughout theirlifetimes.The PRINCIPAL ARCHITECT, ARCHITECTURAL NEXUS DON FINLAYSON,

THE LATE ERINELIZABETH FINLAYSON LOVED ANIMALS, ESPECIALLY HORSES. A BEACONOFHOPE OF HOPERISINGUP INOURCOMMUNITY. WAS DESIGNEDTO SYMBOLIZE A BEACON HUNTSMAN CANCERRESEARCHCENTER THE POINTEDTIP OFTHEJONM.

49 GIVING 50 FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING 2016 GALA andNIGHT OFFFROMCANCER from Cancercelebration. attendees were invitedtothe Take aNight O followed by dinnerandaprogram. Afterward, eevening kickedo withasilentauction Huntsman, andSusan Sheehan. Institute, Gov. Jon M.Huntsman, Jr., Peter R. Karen Huntsman, foundersofHuntsman Cancer Kara Church. egalawashostedby Jon M.and attended theevent, presented by Corbinand doctors,researchers,1,000 supporters, andpatients 2016, attheGrand AmericaHotel. More than FOUNDATION THE ANNUAL HUNTSMAN CANCER Gala washeldSeptember 29, Gala A. ScottAnderson David W.Pershing BOARD OFDIRECTORS Ronald Moffi tt SECRETARY Thomas E.Muir CHIEF FINANCIALOFFICER Susan Sheehan CHIEF OPERATINGOFFICER PRESIDENT AND Peter R.Huntsman CHIEF EXECUTIVEOFFICER Gov. JonM.Huntsman,Jr. CHAIRMAN Jon M.Huntsman,Sr. CHAIRMAN EMERITUS BOARD OFDIRECTORS HUNTSMAN CANCERFOUNDATION PROFESSOR OFMEDICINE MEDICAL ONCOLOGY DIVISION CHIEFOF CANCER RESEARCH PRESIDENTIAL PROFESSORIN JON ANDKARENHUNTSMAN CLINICAL RESEARCH SENIOR DIRECTOROF Sunil Sharma,MD OF BIOLOGY DISTINGUISHED PROFESSOR CHAIR INCANCERRESEARCH PRESIDENTIAL ENDOWED RALPH E.ANDWILLIAT.MAIN CEO ANDDIRECTOR Mary Beckerle,PhD PROFESSOR OFMEDICINE MEDICAL DIRECTOR AFFAIRS ANDEXECUTIVE SENIOR DIRECTOR OF CLINICAL John Sweetenham,MD HUGHES MEDICALINSTITUTE INVESTIGATOR, HOWARD ONCOLOGICAL SCIENCES PROFESSOR ANDCHAIROF CANCER RESEARCH PRESIDENTIAL PROFESSORIN JON ANDKARENHUNTSMAN BASIC SCIENCE SENIOR DIRECTOROF Bradley Cairns,PhD Huntsman Cancer Institute Director’s Cabinet Huntsman CancerInstituteDirector’s EXECUTIVE DIRECTOR CANCER HOSPITAL Ben Tanner,MHA HEMATOLOGIC MALIGNANCIES CHIEF OFHEMATOLOGYAND PROFESSOR ANDDIVISION PROFESSOR OFMEDICINE M.M. WINTROBE RESEARCH TRANSDISCIPLINARY SENIOR DIRECTOROF Michael Deininger,MD,PhD HEALTH SCIENCES PROFESSOR OFPOPULATION POPULATION SCIENCES DIVISION CHIEFOFCANCER CANCER RESEARCH PRESIDENTIAL PROFESSORIN JON ANDKARENHUNTSMAN POPULATION SCIENCES SENIOR DIRECTOROF Cornelia Ulrich,PhD ADMINISTRATION OF FINANCEAND SENIOR DIRECTOR Scott Lloyd,MBA,CPA DERMATOLOGY PROFESSOR OF CUMMING ENDOWEDCHAIR PRECLINICAL TRANSLATION SENIOR DIRECTOROF Martin McMahon,PhD 51 APPENDIX 52 APPENDIX PROFESSOR AND CHAIR OFMEDICINE ENDOWED CHAIR H.A. ANDEDNABENNINGPRESIDENTIAL Kathleen Cooney,MD MEDICAL GROUP PRESIDENT, UNIVERSITYOFUTAH WILMA T.GIBSONPRESIDENTIALPROFESSOR PROFESSOR ANDCHAIROFPEDIATRICS Edward Clark,MD CEO OFUNIVERSITYUTAHHEALTHCARE DEAN OFTHESCHOOLMEDICINE HEALTH SCIENCES SENIOR VICEPRESIDENTFOR Vivian Lee,MD,PhD,MBA DISTINGUISHED PROFESSOROFBIOLOGY ENDOWED CHAIRINCANCERRESEARCH RALPH E.ANDWILLIAT.MAINPRESIDENTIAL HUNTSMAN CANCERINSTITUTE CEO ANDDIRECTOR, INTERNAL ADVISORYBOARDCHAIR Mary Beckerle,PhD Board Internal Advisory

RADIATION ONCOLOGY PROFESSOR ANDCHAIROF CHAIR INCANCERRESEARCH HUNTSMAN CANCERINSTITUTEENDOWED Dennis Shrieve,MD,PhD BOARD OFDIRECTORS CHAIRMAN OFTHEARUPLABORATORIES CHAIR OFPATHOLOGY ARUP PRESIDENTIALPROFESSORAND Peter Jensen,MD PROFESSOR ANDCHAIROFSURGERY ENDOWED CHAIRINSURGERY CATHERINE B.GATESPRESIDENTIAL CLAUDIUS Y.GATES,MD,AND Samuel Finlayson,MD,MPH HEALTH SCIENCES PROFESSOR ANDCHAIROFPOPULATION Angie Fagerlin,PhD

PROFESSOR OFMEDICINEANDCARDIOLOGY UNIVERSITY OFUTAHHEALTHCARE AND CHIEFSCIENTIFICOFFICER, ASSOCIATE VICEPRESIDENTFORRESEARCH OF UTAHSCHOOLMEDICINE VICE DEANOFRESEARCH,UNIVERSITY Dean Li,MD,PhD Ex OfficioMember PROFESSOR ANDCHAIROFDERMATOLOGY John Zone,MD

RESEARCH, THEOHIOSTATEUNIVERSITY ENTERPRISE FOUNDATIONCHAIROFCANCER JL MARAKASNATIONWIDEINSURANCE AND SOLOVERESEARCHCENTER CEO OFTHEJAMESCANCERHOSPITAL COMPREHENSIVE CANCERCENTER DIRECTOR OFTHEOHIOSTATEUNIVERSITY Michael Caligiuri,MD FOR BIOLOGICALSTUDIES PRESIDENT OFTHESALKINSTITUTE IRWIN M.JACOBSPRESIDENTIALCHAIR NOBEL LAUREATE Elizabeth Blackburn,PhD HARVARD MEDICALSCHOOL PROFESSOR OFGENETICS PROFESSOR OFPEDIATRICS DISTINGUISHED PROFESSOROFMEDICINE RICHARD ANDSUSANSMITH DANA-FARBER CANCERINSTITUTE PRESIDENT ANDCEOEMERITUS Edward Benz,MD

THE ROCEKELLERUNIVERSITY MEDICAL INSTITUTE INVESTIGATOR ATHOWARDHUGHES AND DEVELOPMENT OF MAMMALIANCELLBIOLOGY REBECCA C.LANCEFIELDPROFESSOR Elaine Fuchs,PhD UNIVERSITY OFCALIFORNIAATLOSANGELES JONSSON COMPREHENSIVECANCERCENTER, AND PLANNING DEPUTY DIRECTOROFADMINISTRATION Rob DuWors,MPA OREGON HEALTHANDSCIENCEUNIVERSITY MEDICAL INSTITUTE INVESTIGATOR ATHOWARDHUGHES JELD-WEN CHAIROFLEUKEMIARESEARCH OHSU SCHOOLOFMEDICINE ASSOCIATE DEANFORONCOLOGY DIRECTOR OFKNIGHTCANCERCENTER Brian Druker,MD

External Advisory Board External Advisory GEORGETOWN UNIVERSITY MEDICALCENTER F. EDWARD HEBERTSCHOOL OFMEDICINE ADJUNCT PROFESSOR OFMEDICINE RESEARCH DEVELOPMENT ASSOCIATE DEAN FOR PROFESSOR OFMEDICINE WASHINGTON CANCERINSTITUTE MEDICAL DIRECTOR, Sandra M.Swain,MD RESEARCH INSTITUTE MOFFITT CANCERCENTERAND EXECUTIVE VICEPRESIDENT DISTINGUISHED MOFFITSCHOLAR CENTER DIRECTOR Thomas Sellers,PhD,MPH DANA-FARBER CANCERINSTITUTE PROFESSOR OFMEDICALONCOLOGY HARVARD T. H.CHAN SCHOOL OFPUBLIC HEALTH PROFESSOR OFEPIDEMIOLOGY Timothy R.Rebbeck,PhD CANCER CENTER THE UNIVERSITYOFTEXASMDANDERSON EARLY PREVENTIONOFCANCER BOONE PICKENSDISTINGUISHEDCHAIRFOR PREVENTION ANDPOPULATIONSCIENCES VICE PRESIDENTANDDIVISIONCHIEFFORCANCER Ernest T.Hawk,MD,MPH

53 APPENDIX 54 APPENDIX programs includealmost170membersfromacrosstheUniversityofUtahcampus. scientific excellencethroughcoordinated,broad-basedtransdisciplinaryresearch.HCI’s fourCancerCenter The NationalCancerInstituteCenterSupportGrant(CCSG)providesfundingforprogramsthatpromote Cancer CenterResearchProgramsandMembers DISTINGUISHED PROFESSOR OFNURSING Kathleen Mooney, PhD,RN CANCER CONTROL AND POPULATION SCIENCES (CCPS)PROGRAM PROFESSOR OFMEDICINE Sunil Sharma,MD (ET) PROGRAM EXPERIMENTAL THERAPEUTICS ONCOLOGICAL SCIENCES ASSOCIATE PROFESSOROF Jody Rosenblatt,PhD CELL RESPONSE AND REGULATION (CRR)PROGRAM PROFESSOR OFONCOLOGICALSCIENCES Bradley Cairns,PhD NUCLEAR CONTROL OFCELL GROWTH AND DIFFERENTIATION (NC)PROGRAM

ONCOLOGICAL SCIENCES PROFESSOR OF Sean Tavtigian, PhD ASSISTANT PROFESSOROFMEDICINE MEDICAL DIRECTOR Theresa Werner,MD ONCOLOGICAL SCIENCES ASSOCIATE PROFESSOROF Alana Welm,PhD PROFESSOR OFBIOCHEMISTRY Jared Rutter,PhD CLINICAL TRIALSOFFICE

Research Focus:Transcription regulation;nuclearoncogenes PROFESSOR OFONCOLOGICAL SCIENCES Donald Ayer,PhD (NC) adoptive transferofreceptor-modifiedT cell as tumorvaccinations,immunomodulatory antibodies,andthe Research Focus:Novelimmunotherapeutic approachessuch ASSOCIATE PROFESSOROFMEDICINE/HEMATOLOGY/BMT Djordje Atanackovic,MD(ET) testing formutationsthatincreasecancerrisk Research Focus:Psychologicalandbehavioralresponsetogenetic PROFESSOR OFPSYCHOLOGY Lisa Aspinwall,PhD(CCPS) progression usingmousemodels Research Focus:Colondevelopment;coloncancerinitiationand GASTROENTEROLOGY ASSOCIATE PROFESSOROFMEDICINE/ Melinda Angus-Hill,PhD(NC) nodes inpatientswithmelanomaandbreastcancer lymph for thedetectionofsentinel Research Focus:Newmodalities ASSOCIATE PROFESSOROFSURGERY/GENERALSURGERY Robert Andtbacka,MD,CM(ET) Biorespository andMolecularPathologySharedResource Research Focus:DirectoroftheHistologySection Blake Anderson,BS(NPA) mechanisms thatgoverntheactivityofDNAandRNA previously unknownphysical,cellular,andevolutionary molecular biologicaldatathatcanbeusedtocorrectlypredict Research Focus:Matrixandtensormodelingoflarge-scale ASSOCIATE PROFESSOROFBIOENGINEERING ADJUNCT ASSISTANTPROFESSOROFHUMANGENETICS Orly Alter,PhD(CCPS) Research Focus:Experimentaltherapeutics;cancerclinicaltrials PROFESSOR OFMEDICINE/ONCOLOGY Wallace Akerley,MD(ET) Research Focus:Prostateandkidneycancers ASSOCIATE PROFESSOROFMEDICINE/ONCOLOGY Neeraj Agarwal,MD(ET) Research Focus:Plasticsurgeryandreconstructivemicrosurgery ASSOCIATE PROFESSOROFSURGERY/PLASTICSURGERY Jayant Agarwal,MD(ET) CANCER CENTER PROGRAM MEMBERS CANCER CENTERPROGRAMMEMBERS and metastasis;molecular diagnostics Research Focus:Signal transductionintumorinitiation AND TOXICOLOGY ASSOCIATE PROFESSOROFPHARMACOLOGY Andrea Bild,PhD(NC) their inhibitionasatherapeuticstrategyfor cancers Research Focus:Mammalianhistonedeacetylases and ONCOLOGY ASSISTANT PROFESSOROFRADIATION Srividya Bhaskara,PhD(NC) non-solid tumors Research Focus:Moleculardiagnosticsofsolidand ANATOMIC PATHOLOGY ASSOCIATE PROFESSOROFPATHOLOGY/ Philip Bernard,MD(ET) their closerelationships cope withchronichealthconditionssuchascancerand Research Focus:Howindividualsacrossthelifespan PROFESSOR OFPSYCHOLOGY Cindy Berg,PhD(NPA) Ewing sarcoma Research Focus:Celladhesion;cellmigration; PROFESSOR INCANCERRESEARCH RALPH E.ANDWILLIAT.MAINPRESIDENTIAL DISTINGUISHED PROFESSOROFBIOLOGY Mary Beckerle,PhD(CRR) quality oflife;cancersurvivorship Research Focus:Painandsymptommanagement; CHAIR INTHECOLLEGEOFNURSING ROBERT S.ANDBETHM.CARTERENDOWED CHRONIC CARE PROFESSOR OFNURSING/ACUTEAND Susan Beck,PhD,RN(CCPS) (ADARs); RNAinterference(RNAi) editing byadenosinedeaminasesthatactonRNA Research Focus:Double-strandedRNA(dsRNA); ENDOWED CHAIRINBIOCHEMISTRY H.A. ANDEDNABENNINGPRESIDENTIAL DISTINGUISHED PROFESSOROFBIOCHEMISTRY Brenda Bass,PhD(NC) pediatric patients Research Focus:Cancerclinicaltrialsin PEDIATRIC HEMATOLOGY/ONCOLOGY ASSOCIATE PROFESSOROFPEDIATRICS/ Phillip Barnette,MD(ET) targeting MDR Research Focus:Anticancerdrugcarrierdesign AND PHARMACEUTICALCHEMISTRY PROFESSOR OFPHARMACEUTICS You HanBae,MD(ET) Cancer CenterResearchProgramLeadersandMembers

statistical geneticmethods genotype/phenotype relationship;developing traits, includingincreased cancerrisks;evaluating Research Focus:Localizing genesforcomplex HEMATOLOGIC MALIGNANCIES PROFESSOR OFMEDICINE/HEMATOLOGY AND Nicola Camp,PhD(CCPS) DNA methylation Research Focus:Chromatrinremodelingtranscription; PROFESSOR INCANCERRESEARCH JON ANDKARENHUNTSMANPRESIDENTIAL PROFESSOR OFONCOLOGICALSCIENCES Bradley Cairns,PhD(NC) cancer screening Research Focus:Breastcancergenetics; PROFESSOR OFMEDICINE/ONCOLOGY Saundra Buys,MD(CCPS) DNA damage Research Focus:Chemistryandbiochemistryof OF BIOLOGICALCHEMISTRY THATCHER PRESIDENTIALENDOWEDCHAIR DISTINGUISHED PROFESSOROFCHEMISTRY Cynthia Burrows,MD(NC) of cancer that mightreducetrendstowardoverweightandrisk Research Focus:Healthylevelsofphysicalacitivy CONSUMER STUDIES PROFESSOR OFFAMILYAND Barbara Brown,PhD(CCPS) gastrointestinal tract Research Focus:Cancerouscellgrowthinthe OF PATHOLOGY CARL R.KJELDSBERGPRESIDENTIALCHAIR ANATOMIC PATHOLOGY PROFESSOR OFPATHOLOGY/ Mary Bronner,MD(ET) drug deliverysystems guidelines inepilepsy;painmanagementoutcomes; and prospectivepatientassessment;care Research Focus:Retrospectivedatabasestudies PROFESSOR OFPHARMACOTHERAPY Diana Brixner,PhD(NPA) Research Focus:Cancerbiostatistics OF MEDICINE/EPIDEMIOLOGY RESEARCH ASSOCIATEPROFESSOR Kenneth Boucher,PhD(CCPS) composition incolorectalcancer Research Focus:Diabetes,obesity,andbody POPULATION HEALTHSCIENCES OF POPULATIONHEALTHSCIENCES/CANCER RESEARCH ASSISTANTPROFESSOR Juergen Boehm,MD(CCPS)

activity ofWntsand bone morphgeneticproteins Research Focus:Celluar mechanismsthatregulatethe PROFESSOR OFNEUROBIOLOGY ANDANATOMY Jan Christian,PhD(CRR) achieve therapeuticbenefits methods inengineeringpeptidesandproteins to Research Focus:Newchemicalandbiochemical ASSISTANT PROFESSOROFBIOCHEMISTRY Danny Chou,PhD(ET) resistance or/andmetastasis to delivercancer-stemcell-specificdrugshaltdrug Research Focus:Polypeptide-basednanoparticles AND PHARMACEUTICALCHEMISTRY ASSISTANT PROFESSOROFPHARMACEUTICS Mingnan Chen,PhD(ET) maintenance pathways modifications ingenetranscriptionandgenomestability Research Focus:Regulationandfunctionofhistone RADIATION ONCOLOGY RESEARCH ASSISTANTPROFESSOROF Mahesh Chandrasekharan,PhD(NC) or cellularorginthatregulategeneexpression Research Focus:Functionsofnon-codingRNAsviral ASSISTANT PROFESSOROFBIOCHEMISTRY Demian Cazalla,PhD,MS(NC) relationship withself-carepractices influence healthandwell-beingoutcomes;intervening Research Focus:Howaspectsofcancercaregiving ENDOWED CHAIRINHEALTHYAGING ROBERT L.ANDJOYCET.RICEPRESIDENTIAL CARE DIVISION SYSTEMS ANDCOMMUNITY-BASED PROFESSOR OFNURSINGINTHEHEALTH Michael Caserta,PhD(CCPS) Research Focus:Genetargeting PROFESSOR OFBIOCHEMISTRY Dana Carroll,PhD(NC) genetic recombination Research Focus:Mammaliandevelopment; IN THEHEALTHSCIENCESCENTER BAMBERGER PRESIDENTIALENDOWEDCHAIR HELEN LOWEBAMBERGERCOLBYANDJOHNE. GENETICS DISTINGUISHED PROFESSOROFHUMAN Mario Capecchi,PhD(NC) melanoma andprostatecancer disease predispositiongeneswithanemphasison Research Focus:Breastcancersusceptibilitygenes; GENETIC EPIDEMIOLOGY PROFESSOR OFMEDICINE/ Lisa Cannon-Albright,PhD(CCPS)

55 APPENDIX 56 APPENDIX and BioinformaticAnalysis SharedResource Research Focus:Director ofHigh-ThroughputGenomics Brian Dalley,PhD (NPA) cancer andtheirrelationshiptoenvironmental influences Research Focus:Geneticandepigenetic riskfactorsfor OF MEDICINE/GENETICEPIDEMIOLOGY RESEARCH ASSISTANTPROFESSOR Karen Curtin,PhD,M.Stat(CCPS) and chronicgraft-versus-hostdisease Research Focus:Bonemarrowtransplantation;acute PROFESSORSHIP INADULTLEUKEMIARESEARCH HUNTSMAN CANCERINSTITUTEENDOWED HEMATOLOGIC MALIGNANCIES PROFESSOR OFMEDICINE/HEMATOLOGYAND Daniel Couriel,MD(ET) Shared Resource Research Focus:DirectorofInformatics Samir Courdy,MBA(NPA) defects insporadicandhereditaryprostatecancer Research Focus:Furtheringtheabilitytoidentifygenetic ENDOWED CHAIR H. A.ANDEDNABENNINGPRESIDENTIAL PROFESSOR OFMEDICINE Kathleen Cooney,MD(CCPS) breast/ovarian cancergenesandalleles Genetics caseinvolvingthepatentingofBRCA1/2 Research Focus:Genepatenting,particularlytheMyriad ASSOCIATE PROFESSOROFLAW Jorge Contreras,JD(CCPS) brain tumors Research Focus:Treatmentofprimaryandmetastatic ADULT NEUROSURGERY ASSOCIATE PROFESSOROFNEUROSURGERY/ Howard Colman,MD,PhD(ET) strategies andapproaches as apreludetothedevelopmentofbettertherapeutic Research Focus:Signalingpathwaysinprostatecancer ANATOMIC PATHOLOGY PROFESSOR OFPATHOLOGY/ Michael Cohen,MD(CRR) for brainandbreastcancer Research Focus:Personalizingtreatmentdecisions ASSISTANT PROFESSOROFMEDICINE/ONCOLOGY Adam Cohen,MD(ET) cancer survivors Research Focus:Cancercommunicationswithbreast AND CHRONICCARE ASSOCIATE PROFESSOROFNURSING/ACUTE Margaret Clayton,PhD,APRN(CCPS) Cancer CenterResearchProgramLeadersandMembers

these materialstosupport researchatHCI biospecimens related tocancerresearchandprovide Molecular Pathology SharedResourcetoobtain Research Focus:ManagingtheBiorepository and Chris Fillmore,PhD(NPA) scale genomicdata bioinformatic andstatisticaltoolsforanalysis oflarge- epidemiology ofcomplexdiseases;development of Research Focus:Epidemiologyandgenetic OF DERMATOLOGY RESEARCH ASSISTANTPROFESSOR Bingjian Feng,PhD(NPA) treatment betweenpatientsandtheirphysicians making regardingcancerscreeningand Research Focus:Methodstoimproveshareddecision PROFESSOR OFPOPULATIONHEALTHSCIENCES Angela Fagerlin,PhD(CCPS) Research Focus:Breastcancerpathology ANATOMIC PATHOLOGY ASSISTANT PROFESSOROFPATHOLOGY/ Rachel Factor,MD,MHS(CRR) tissue, culturedhumancells,andzebrafishmodels using acombinationofapproaches,includinghuman progression andidentifyingpotentialtreatmentsforHCC Research Focus:MechanismofHCCinitiationand ANATOMIC PATHOLOGY ASSISTANT PROFESSOROFPATHOLOGY/ Kimberley Evason,MD,PhD(CRR) relationships thatgovernnormalhematopoiesis leukemias andtheperturbationsofregulatory Research Focus:Molecularpathogenesisofacute PEDIATRIC HEMATOLOGY/ONCOLOGY ASSISTANT PROFESSOROFPEDIATRICS/ Michael Engel,MD,PhD,FAAP(NC) psycho-oncology Research Focus:Patient-providercommunication CHRONIC CARE ASSOCIATE PROFESSOROFNURSING/ACUTEAND Lee Ellington,PhD(CCPS) cancer, andqualityoflifeinprogressivedisease integration inthefieldsofacuteandchronicpain, Research Focus:Substantiveandmethodological PROFESSOR OFANESTHESIOLOGY Gary Donaldson,PhD(CCPS) predict clinicalresponse malignancies: targetanddrugdiscovery;biomarkersto Research Focus:Moleculartherapyofhematologic M.M. WINTROBEPROFESSOROFMEDICINE HEMATOLOGIC MALIGNANCIES PROFESSOR OFMEDICINE/HEMATOLOGYAND Michael Deininger,MD,PhD(ET)

melanoma; clinicalclassification ofBRCA1andBRCA2 Research Focus:Genetic studiesofbreastcancerand RESEARCH PROFESSOR OFDERMATOLOGY David Goldgar,PhD(CCPS) therapy ofheadandneckcancer Research Focus:Designofnewpolymers forgene PHARMACEUTICAL CHEMISTRY PROFESSOR OFPHARMACEUTICSAND Hamidreza Ghandehari,PhD(ET) during cancerprogression Research Focus:Howgeneregulationisimpacted ONCOLOGICAL SCIENCES ASSISTANT PROFESSOROF Jason Gertz,PhD(NC) Research Focus:Pancreaticductaladenocarcinoma(PDA) ASSISTANT PROFESSOROFMEDICINE/ONCOLOGY Ignacio Garrido-Laguna,MD,PhD(ET) and lymphoma Research Focus:Radiotherapyforgynecology,breast, PROFESSOR OFRADIATIONONCOLOGY David Gaffney,MD,PhD(ET) Research Focus:Defectivesignalinginmedulloblastoma ADULT NEUROSURGERY PROFESSOR OFNEUROSURGERY/ Daniel Fults,MD(CRR) how malignancychangesthesemechanisms Research Focus:Mechanismsofcellularphysiology; OF BIOCHEMISTRY ADJUNCT ASSISTANTPROFESSOR Adam Frost,MD,PhD(CRR) of ligand-targetedtherapeuticsasanticancerdrugs as anadvancedtoolfordrugdiscoveryandthepursuit Research Focus:DevelopmentofDNA-encoded libraries MEDICINAL CHEMISTRY ASSISTANT PROFESSOROF Raphael Franzini,PhD(ET) Research Focus:DNAreplicationinyeast PROFESSOR OFBIOCHEMISTRY Timothy Formosa,PhD(NC) pediatric patients Research Focus:Cancerclinicaltrialsin PEDIATRIC HEMATOLOGY/ONCOLOGY ASSOCIATE PROFESSOROFPEDIATRICS/ Mark Fluchel,MD(CCPS)

musculoskeletal disease Research Focus:Molecular imagingfor ASSISTANT PROFESSOR OFRADIOLOGY Chris Hanrahan,MD,PhD(NPA) as atherapeuticmodalityforcancertreatment Research Focus:Immunotherapy/immunomodulation HEMATOLOGY/BMT ASSISTANT PROFESSOROFMEDICINE/ Ahmad Halwani,MD(ET) Research Focus:Bladdercancer INSTRUCTOR OFMEDICINE/ONCOLOGY Sumati Gupta,MD(ET) Research Focus:Celldifferentiationinthezebrafish ENDOWED CHAIRINHUMANGENETICS HELEN LOWEBAMBERGERCOLBYPRESIDENTIAL PROFESSOR OFHUMANGENETICS David Grunwald,PhD(NC) other signalingpathwaysinmelanomatumors Research Focus:Demethylaseenzymecomplexand ASSISTANT PROFESSOROFMEDICINE/ONCOLOGY Kenneth Grossmann,MD,PhD(ET) therapeutic interventions progression; Identificationanddevelopmentof Research Focus:Mechanismsofcancerdisease ANATOMIC PATHOLOGY ASSISTANT PROFESSOROFPATHOLOGY/ Allie Grossmann,MD,PhD(CRR) in melanoma and cellcycleregulatorSurvivin;oxidativestress skin cancerdevelopment,withfocusonapoptosis Research Focus:Apoptoticmechanismsunderlying PROFESSOR OFDERMATOLOGY Douglas Grossman,MD,PhD(CRR) Shared Resource Research Focus:DirectorofCancerBiostatistics PRESIDENTIAL ENDOWEDCHAIR H. A.ANDEDNABENNING SCIENCES, DIVISIONOFBIOSTATISTICS PROFESSOR OFPOPULATIONHEALTH Tom Greene,PhD(NPA) transcriptional regulation Research Focus:DNA-proteininteractions;eukaryotic PROFESSOR OFONCOLOGICALSCIENCES Barbara Graves,PhD(NC) structure andfunction Research Focus:Drosophilagenetics;chromosome PROFESSOR OFBIOLOGY Kent Golic,PhD(NC)

Cancer CenterResearchProgramLeadersandMembers

mechanisms underlying tumorigenesisandprogression Research Focus:Tumor hypoxiaandmolecular ADULT NEUROSURGERY ASSOCIATE PROFESSOROFNEUROSURGERY/ L. EricHuang,MD,PhD(NC) their applicationtocancerdiagnosisand screening prognostic studyinclinicaltrialssurvival analysisand Research Focus:Statisticalmethodology indiagnostic/ EPIDEMIOLOGY RESEARCH ASSISTANTPROFESSOROFMEDICINE/ Nan Hu,PhD,MS(CCPS) molecular targetsforcancertherapy Research Focus:Toidentifyandvalidatenovel GENERAL SURGERY ASSOCIATE PROFESSOROFSURGERY/ Sheri Holmen,PhD(CRR) cigarette smoking for nicotineaddictionandtheconsequencesof Research Focus:Geneticandmolecularbasis E. NIELSON,ANDMR.DOUGLASW.NIELSON O. NIELSON,DR.KENNETHA.PAUL MEMORY OFDR.ANDMRS.A.J.NIELSON,KARL ENDOWED CHAIRINTHESCHOOLOFMEDICINE CLARENCE M.ANDRUTHN.BIRRERPRESIDENTIAL PROFESSOR OFMEDICINE John Hoidal,MD(NPA) and complications imaging ofcancer-associatedphysiologicchanges Research Focus:Molecularimaging;PET DAUGHTER, MARYBOESCHE ESTABLISHED INLOVINGMEMORYBYHIS ENDOWED CHAIRINCANCERRESEARCH WILLARD SNOWHANSENPRESIDENTIAL CLINICAL RADIOLOGY PROFESSOR OFRADIOLOGY/ John Hoffman,MD(ET) remodeling andreorganization that functioninproteasomeactivation;nucleosome Research Focus:Structureandmechanismsofproteins IN BIOCHEMISTRY PRESIDENTIAL ENDOWEDCHAIR DR. LEOT.SAMUELSANDBARBARAK. DISTINGUISHED PROFESSOROFBIOCHEMISTRY Christopher Hill,PhD(NC) of cancer Research Focus:Globalandmolecularepidemiology PREVENTIVE MEDICINE/PUBLICHEALTH ASSOCIATE PROFESSOROFFAMILYAND Mia Hashibe,PhD(CCPS) of healththroughoutthelifecourse understanding geneticandenvironmentaldeterminants Research Focus:Healthyagingandlongevityby AND PREVENTIVEMEDICINE/PUBLICHEALTH RESEARCH ASSISTANTPROFESSOROFFAMILY Heidi Hanson,PhD,MS(CCPS)

epigenetic modulation Research Focus:Cancer immunotherapy; ASSOCIATE PROFESSOR OFMEDICINE/ONCOLOGY Hung Khong,MD(ET) related disparitiesamongvulnerablepopulations specifically HPVvaccination;prevention ofcancer- andcontrol, Research Focus:Cervicalcancerprevention AND CHRONICCARE ASSISTANT PROFESSOROFNURSING/ACUTE Deanna Kepka,PhD,MPH,MA(CCPS) information relatedtocancerrisk Research Focus:Communicatinggeneticandgenomic PROFESSOR OFCOMMUNICATIONS Kimberly Kaphingst,ScD(CCPS) Research Focus:Celladhesionandmigrationincancer ONCOLOGICAL SCIENCES RESEARCH ASSISTANTPROFESSOROF Julie Kadrmas,PhD(CRR) positron emissiontomography(PET)imaging Research Focus:Biomaterialsanddrugdelivery; PROFESSOR OFRADIOLOGY Dan Kadrmas,PhD(ET) sarcoma progression Research Focus:Mesenchymaltransformation; ASSISTANT PROFESSOROFORTHOPAEDICS Kevin Jones,MD(NC) Research Focus:Braintumorangiogenesisandhypxoxia ADULT NEUROSURGERY PROFESSOR OFNEUROSURGERY/ Randy Jensen,PhD(ET) behavioral interventions psychometrics ofkeycancerconstructs;designand Research Focus:Cancercommunication; ASSISTANT PROFESSOROFCOMMUNICATIONS Jakob Jensen,PhD(CCPS) systems forclinicalcancertherapy Research Focus:Novel,mainlynanotechnology-based GYNECOLOGIC ONCOLOGY OBSTETRICS ANDGYNECOLOGY/ RESEARCH ASSISTANTPROFESSOROF Margit Janat-Amsbury,MD,PhD(ET) natural products Research Focus:Cancergenetics;marine PROFESSOR OFMEDICINALCHEMISTRY Chris Ireland,PhD(ET)

57 APPENDIX 58 APPENDIX biomarker ofacutemyeloid leukemiastemcells immunoglobulin and mucin domain-3(TIM-3),acandidate Research Focus:Expression andfunctionofT-cell HEMATOLOGY ANDHEMATOLOGICMALIGNANCIES ASSISTANT PROFESSOROFMEDICINE/ Catherine Lee,MD(CCPS) cancer patients cancer preventionmeasuresandquality oflifefor sustainable interventionsinthepopulationtoimprove interventions, performcontrolledtrials,andestablish Research Focus:Utilizeetiologicalinformation,identify PREVENTIVE MEDICINE VISITING INSTRUCTOROFFAMILYAND Amy Lee,PhD(CCPS) Research Focus:Melanomageneticstranslation ADJUNCT PROFESSOROFDERMATOLOGY Sancy Leachman,MD,PhD(CCPS) Research Focus:Agingcancerpatientsandsurvivors PROFESSOR OFPHYSICALTHERAPY Paul LaStayo,PhD(CCPS) activity, andobesity the socialenvironmentandenergybalance,physical Research Focus:Cancer-relatedassociationsbetween CONSUMER STUDIES ASSOCIATE PROFESSOROFFAMILYAND Lori Kowaleski-Jones,PhD(NPA) (AML), andmultiplemyeloma lymphoblastic leukemia(ALL),acutemyeloid Research Focus:Preventionandtreatmentofacute PROFESSOR OFMEDICINE/HEMATOLOGY/BMT Tibor Kovacsovics,MD(ET) Research Focus:Biomaterialsanddrugdelivery AND PHARMACEUTICALCHEMISTRY DISTINGUISHED PROFESSOROFPHARMACEUTICS Jindrich Kopecek,MD(ET) Shared Resource Research Focus:DirectorofGeneticCounseling Wendy Kohlmann,MA(NPA) economic outcomesforchildhoodcancersurvivors Research Focus:Howcanceraffectssocialand PEDIATRIC HEMATOLOGY/ONCOLOGY ASSISTANT PROFESSOROFPEDIATRICS/ Anne Kirchhoff,PhD,MPH(CCPS) angiogenesis targeting Research Focus:Medicalpolymersanddrugdelivery; AND PHARMACEUTICALCHEMISTRY DISTINGUISHED PROFESSOROFPHARMACEUTICS Sung WanKim,PhD(ET) Cancer CenterResearchProgramLeadersandMembers

access tocarewitha focusonintegrativeoncology Research Focus:Collaborative researchtoinform PROFESSOR OFMEDICINE/ONCOLOGY Ana MariaLopez,MD,MPH(CCPS) cancer cells inspired compoundsthatcausezinc-dyshomeostasis in action, withaparticularinterestinnatural product- under-utilized orunder-appreciatedmechanismsof Research Focus:Synthesisofnewcompoundswith ASSOCIATE PROFESSOROFCHEMISTRY Ryan Looper,PhD(ET) guideline creationanduse clinical trialresearchquestions,enrollment,andfunding; modalities incancercare;bibliometricanalysisof to determinethebestwayscombinetreatment Research Focus:Comparativeeffectivenessresearch ONCOLOGY ASSISTANT PROFESSOROFRADIATION Shane Lloyd,MD(NPA) support symptomassessmentandinterventions adolescents withanemphasisontheuseoftechnologyto Research Focus:Symptommanagementforchildrenand AND CHRONICCARE ASSISTANT PROFESSOROFNURSING/ACUTE Lauri Linder,PhD(CCPS) cancer cells Research Focus:Targetingapoptoticmechanismsin AND PHARMACEUTICALCHEMISTRY ASSOCIATE PROFESSOROFPHARMACEUTICS Carol Lim,PhD(CRR) angiogenesis incancer Research Focus:Signalinginangiogenesis;targeting CARDIOVASCULAR MEDICINE PROFESSOR OFMEDICINE/ Dean Li,MD,PhD(CRR) bioinformatics, andhumancomputerinteraction Research Focus:Visualanalysisofbiologicaldata, ASSISTANT PROFESSOROFCOMPUTERSCIENCE Alexander Lex,PhD(NPA) human genetics Research Focus:Melanomageneticstranslation; HUMAN GENETICS DISTINGUISHED PROFESSOROF Mark Leppert,PhD(CCPS) Research Focus:Generegulationbystress PROFESSOR OFMEDICINE/HEMATOLOGY/BMT Elizabeth Leibold,PhD(NC)

behaviors; cancersymptom experience Research Focus:Quality oflife;preventionadherance NURSING RESEARCH PRESIDENTIAL ENDOWEDCHAIRIN LOUIS S.PEERY,MD,ANDJANETB.PEERY AND CHRONICCARE DISTINGUISHED PROFESSOROFNURSING/ACUTE Kathleen Mooney,PhD,RN(CCPS) head andneckcancers thyroid cancer;cancerriskstratification;HPV Research Focus:Survivorshipinheadandneck OTOLARYNGOLOGY ASSISTANT PROFESSOROFSURGERY/ Marcus Monroe,MD(CCPS) Research Focus:Epidemiologyofcancer ONCOLOGICAL SCIENCES RESEARCH PROFESSOROF Geraldine Mineau,PhD,MPH(CCPS) leukemia andBurkittlymphoma in thebiology;prognosisofpediatriclymphoblastic Research Focus:Roleofgenecopynumberchanges CLINICAL PATHOLOGY ASSISTANT PROFESSOROFPATHOLOGY/ Rodney Miles,MD,PhD(NC) that controlthecytoskeletalchangesofcellmotility Research Focus:Biochemicalsignalingmechanisms ONCOLOGICAL SCIENCES ASSISTANT PROFESSOROF Michelle Mendoza,PhD(CRR) models ofcancer suppressors, experimentaltherapeutics,andmouse Research Focus:Signaltransduction,oncogenes,tumor PROFESSOR OFDERMATOLOGY Martin McMahon,PhD(CRR) communication andeducation we caninfluencetheseperceptionsthroughbetter understand theirdiseaseandmanagementhow Research Focus:Howpatientsperceiveand GENERAL SURGERY ASSISTANT PROFESSOROFSURGERY/ Cindy Matsen,MD(NPA) variant identificationandinterpretation Research Focus:Computationalbiology;genomic PROFESSOR OFHUMANGENETICS Gabor Marth,DSc(CCPS) urologic malignancies Research Focus:Surgicaltreatmentof ASSISTANT PROFESSOROFSURGERY/UROLOGY William Lowrance,MD,MPH(CCPS)

relevant samples basic researcherswith avastrepositoryofclinically testing intoclinicaltrial protocolsandproviding to enableresearchers tointegratereal-timemolecular Research Focus:Quicklyobtainingpatient specimens John O’Shea,PhD(NPA) therapeutic targetinleukemia and coordinationoffunction-firstprofiling fornew including leukemiastemcells;design,validation, mechanism-based targetingofleukemiccells, development forchronicandacuteleukemias; Research Focus:Targetdiscoveryandinhibitor MEDICINE/HEMATOLOGY/BMT RESEARCH ASSOCIATEPROFESSOROF Thomas O’Hare,PhD(CRR) and tumorimmunity Research Focus:RolesofnoncodingRNAsinleukemia MICROBIOLOGY ANDIMMUNOLOGY ASSISTANT PROFESSOROFPATHOLOGY/ Ryan O’Connell,PhD(NC) Research Focus:Geneticetiologyofcoloncancer MEDICINE/GENETIC EPIDEMIOLOGY RESEARCH ASSOCIATEPROFESSOROF Deborah Neklason,PhD(CCPS) Research Focus:Nutritionepidemiologyincancer EPIDEMIOLOGY ASSOCIATE PROFESSOROFMEDICINE/ Maureen Murtaugh,PhD(NPA) Research Focus:Pancreaticdevelopmentandcancer ASSOCIATE PROFESSOROFHUMANGENETICS L. CharlesMurtaugh,PhD(CRR) Research Focus:Biologyofpancreaticcancer ELLIOTT V.ANDERSONINHONOROFHISFATHER ENDOWED CHAIRINSURGERYESTABLISHEDBY ROSS R.ANDERSON,MD,PRESIDENTIAL PROFESSOR OFSURGERY/GENERALSURGERY Sean Mulvihill,MD(ET) and complications imaging ofcancer-associatedphysiologicchanges Research Focus:Molecularimaging;PET CLINICAL RADIOLOGY PROFESSOR OFRADIOLOGY/ Kathryn Morton,MD(ET) of breastcancer Research Focus:BreastMRIandcharacterization CLINICAL RADIOLOGY ASSOCIATE PROFESSOROFRADIOLOGY/ Glen Morrell,MD,PhD(ET) selenoprotein functionincancer Research Focus:Redoxdysregulationincancer; AND TOXICOLOGY ASSOCIATE PROFESSOROFPHARMACOLOGY Philip Moos,MD,MPH(CRR) Cancer CenterResearchProgramLeadersandMembers

cell metastasis death anddivision;novel mechanismsforinitiatingtumor Research Focus:Mechanisms andregulationofcell ENDOWED CHAIR H.A. ANDEDNABENNINGPRESIDENTIAL ONCOLOGICAL SCIENCES ASSOCIATE PROFESSOROF Jody Rosenblatt,PhD(CRR) Research Focus:Geneticsofsarcoma FOR CANCERRESEARCH L.B. ANDOLIVES.YOUNGENDOWEDCHAIR PROFESSOR OFORTHOPAEDICS R. LorRandall,MD,FACS(ET) lymphoblastic leukemia(ALL)andlymphoma and hematologicdisorders,withanemphasisonacute Research Focus:Treatmentofallpediatriccancers PEDIATRIC HEMATOLOGY/ONCOLOGY PROFESSOR (CLINICAL)OFPEDIATRICS/ Elizabeth Raetz,MD(ET) leading tomyeloproliferativedisorders Research Focus:Germlineandsomaticmutations NUGENT CHAIRINMEDICINE CHARLES A.NUGENT,JR,MD,ANDMARGARET PROFESSOR OFMEDICINE/HEMATOLOGY/BMT Josef Prchal,MD(ET,NC) cancer markers,includingPSAandpancreatic creating ultrasensitiveandreal-timeassaystodetect Research Focus:Innovationsinnanotechnologyfor PROFESSOR OFCHEMISTRY Marc Porter,PhD(ET) design; MRIguidedthermalablationoftumors Research Focus:MRangiography;MRIscanner ADVANCED MEDICALTECHNOLOGIES MARK H.HUNTSMANENDOWEDCHAIRIN PROFESSOR OFRADIOLOGY Dennis Parker,PhD(ET) cancer diagnosisandtreatment (e.g., antibodies,growthfactors)thatcanbeusedfor Research Focus:Creatingbiopharmaceuticals AND PHARMACEUTICALCHEMISTRY ASSISTANT PROFESSOROFPHARMACEUTICS Shawn Owen,PhD(ET) chemotherapeutic resistance;p53regulation Research Focus:Mousemodelsoflungcancer; ONCOLOGICAL SCIENCES ASSISTANT PROFESSOROF Trudy Oliver,PhD(CRR)

biology; acuteleukemia; myelodysplasticsyndromes Research Focus:Nitric oxideandhematopoieticcell PROFESSOR OFMEDICINE/HEMATOLOGY/BMT Paul Shami,MD(ET) childhood cancers with aspecialinterestingeneticsusceptibility to Research Focus:Pediatrichereditarycancer syndromes PEDIATRIC HEMATOLOGY/ONCOLOGY ASSOCIATE PROFESSOROFPEDIATRICS/ Joshua Schiffman,MD(NC) mechanisms ofmetastases Research Focus:Pancreascancermodeling; GENERAL SURGERY ASSOCIATE PROFESSOROFSURGERY/ Courtney Scaife,MD(ET) Research Focus:Colorectalcancergenetics ANATOMIC PATHOLOGY PROFESSOR OFPATHOLOGY/ Wade Samowitz,MD(CCPS) endoscopic oncology Research Focus:Gastrointestinalcancersyndromes; GASTROENTEROLOGY ASSISTANT PROFESSOROFMEDICINE/ N. JewelSamadder,MD,MSc(CCPS) Research Focus:Metabolicsignaling CHAIR INCANCERRESEARCH DEE GLENANDIDAW.SMITHENDOWED PROFESSOR OFBIOCHEMISTRY Jared Rutter,PhD(NC) treatment decisionsofolderadults Research Focus:Cancerscreening,diagnosis,and MEDICINE/GERIATRICS ASSOCIATE PROFESSOROF Randall Rupper,MD,MPH(CCPS) immune response Research Focus:Howthemicrobiotainfluences MICROBIOLOGY ANDIMMUNOLOGY ASSISTANT PROFESSOROFPATHOLOGY/ June Round,PhD(CRR) individuals withcancer biobehavioral modelsforimprovingqualityoflife Research Focus:Cancersupportgroupsand CARE DIVISION HEALTH SYSTEMSANDCOMMUNITY-BASED RESEARCH ASSISTANTPROFESSOROFNURSING, Erin Rothwell,PhD(CCPS)

59 APPENDIX 60 APPENDIX embryogenesis and cancer Research Focus:Cell survivalandmigrationduring ONCOLOGICAL SCIENCES ASSISTANT PROFESSOROF Rodney Stewart,PhD,MPhil(CRR) role ofproteasesincancer Research Focus:Cellpolarity;cellmigration andthe ASSISTANT PROFESSOROFHUMANGENETICS Gillian Stanfield,PhD(CRR) adolescent andyoungadultcancerpatients quality oflifeassessment;decisionmakingin Research Focus:PhaseIdevelopmentaltherapeutics; PEDIATRIC HEMATOLOGY/ONCOLOGY ASSISTANT PROFESSOROFPEDIATRICS/ Holly Spraker-Perlman,MD,MS(NPA) cancer progressionandresponsetotherapy Research Focus:Howchangesincellularidentityaffect ANATOMIC PATHOLOGY ASSISTANT PROFESSOROFPATHOLOGY/ Eric Snyder,MD,PhD(NC) genetic testing Research Focus:Psychosocialconsequencesof CONSUMER STUDIES PROFESSOR OFFAMILYAND Ken Smith,PhD,MS(CCPS) and geneticfactorsaffectingcancerdevelopment Research Focus:Epidemiologicalmethods,environmental PROFESSOR OFMEDICINE/EPIDEMIOLOGY Martha Slattery,PhD(CCPS) chemotherapy/radiotherapy to radiationandchemotherapycombined tumors; mechanismsofintrinsiccellularresistance Research Focus:Intrinsicradiosensitivityofhuman IN CANCERRESEARCH HUNTSMAN CANCERINSTITUTEENDOWEDCHAIR PROFESSOR OFRADIATIONONCOLOGY Dennis Shrieve,MD,PhD(ET) by developingnewimagingandtreatments progression ofpancreascancer;improvepatientcare importance oftumor-stromainteractionsinthe Research Focus:Betterunderstandingofthe OF SURGERY/GENERALSURGERY RESEARCH ASSISTANTPROFESSOR Jill Shea,PhD(NPA) patients withgastrointestinalcancersandraretumors and testingofnewcancertherapies;treatment Research Focus:PhaseIclinicaltrials;development PROFESSOR INCANCERRESEARCH JON ANDKARENHUNTSMANPRESIDENTIAL PROFESSOR OFMEDICINE/ONCOLOGY Sunil Sharma,MD,MBA,FACP(ET) Cancer CenterResearchProgramLeadersandMembers

and cancer Research Focus:Colorectal cancer;exercise PROFESSOR INCANCER RESEARCH JON ANDKARENHUNTSMANPRESIDENTIAL POPULATION HEALTHSCIENCES DIVISION OFCANCERCONTROLAND PROFESSOR OFPOPULATIONHEALTH SCIENCES Cornelia Ulrich,PhD,MS(CCPS) suppressors inbreastcancer Research Focus:Celldivision,biomarkers,andtumor PROFESSOR OFONCOLOGICALSCIENCES Katharine Ullman,PhD(CRR) hormone action Research Focus:Geneexpression;steroid PROFESSOR OFHUMANGENETICS Carl Thummel,PhD(NC) genes, primarilybreast,ovarian,andprostate of intermediate-riskandhigh-riskcancersusceptibility Research Focus:Identificationandcharacterization PROFESSOR INCANCERRESEARCH JON ANDKARENHUNTSMANPRESIDENTIAL PROFESSOR OFONCOLOGICALSCIENCES Sean Tavtigian,PhD(CCPS) Research Focus:Mammaliangeneregulationincancer PATHOLOGY INHONOROFERNSTJ.EICHWALD,MD C. SCOTTANDDOROTHYE.WATKINSCHAIRIN MICROBIOLOGY ANDIMMUNOLOGY ASSOCIATE PROFESSOROFPATHOLOGY/ Dean Tantin,PhD(NC) malignant lymphomas Research Focus:Newtreatmentstrategiesfor PROFESSOR OFMEDICINE/HEMATOLOGY/BMT MD, FRCP,FACP(ET) Sweetenham, John Research Focus:Molecularepidemiologyofcancer MEDICINE/EPIDEMIOLOGY ASSOCIATE PROFESSOROF Carol Sweeney,PhD(CCPS) herpes viruses;RNAexport Research Focus:Post-transcriptionalgeneregulationin INVESTIGATION OFVECTORBORNEDISEASES DIVISION OFINFECTIOUSDISEASESFORTHE DR. DONMERRILLREESENDOWEDCHAIRINTHE PROFESSOR OFMEDICINE Sankar Swaminathan,MD(NC) Research Focus:Membranetrafficking;cytokinesis PROFESSOR OFBIOCHEMISTRY Wesley Sundquist,PhD(CRR)

Research Focus:High riskbreast/ovariancancer MEDICINE/ONCOLOGY ASSISTANT PROFESSOR OF Theresa Werner,MD(ET) health, includingcancer Research Focus:Socio-environmentalinfluences on ASSISTANT PROFESSOROFSOCIOLOGY Ming Wen,PhD(CCPS) drug screening Research Focus:Breastcancerstemcells; GENERAL SURGERY ASSOCIATE PROFESSOROFSURGERY/ Bryan Welm,PhD(CRR) particularly breastcancer Research Focus:Tumorinflammationandcancer, ONCOLOGICAL SCIENCES ASSOCIATE PROFESSOROF Alana Welm,PhD(CRR) care, andend-of-lifecare Research Focus:Pain,neuropathicpain,palliative PROFESSOR OFANESTHESIOLOGY Sharon Weinstein,MD,FAAHPM(NPA) cancer treatmentguidelines Research Focus:Breastcancerpreventiontrials;breast PROFESSOR OFMEDICINE/ONCOLOGY John Ward,MD(ET) and therapy cancers; designoftheranosticsforcancerimaging Research Focus:Targetedtherapeuticsforadvanced OF RADIOLOGY RESEARCH ASSISTANTPROFESSOR Xuli Wang,PhD(ET) cancer syndromes peripheral nervesheathtumor;geneticsoffamilial Research Focus:Neurofibromatosistype1;malignant PROFESSOR OFPEDIATRICS David Viskochil,MD,PhD(NPA) treatment responseanddiseaseprogression defects inbreastcancerthatareassociatedwith Research Focus:Characterizingthetranscriptional ONCOLOGICAL SCIENCES ASSISTANT PROFESSOROF Katherine Varley,PhD(NC) developed fortherapeuticinterventionstrategies Research Focus:Novelmoleculartargetsthatcanbe GENERAL SURGERY ASSISTANT PROFESSOROFSURGERY/ Matthew VanBrocklin,PhD(CRR)

NPA: CCPS: ET: EXPERIMENTALTHERAPEUTICSPROGRAM CRR: DIFFERENTIATION PROGRAM NC: in cancer Research Focus:Celladhesionandinflammation;thrombosis PROFESSOR OFMEDICINE/PULMONARY Guy Zimmerman,MD(CRR) Photovoice methodology;post-traumaticstressandgrowth Research Focus:Youngadultsurvivorsofchildhoodcancer; ASSISTANT PROFESSOROFSOCIALWORK Jaehee Yi,PhD(NPA) response usingimagingbiomarkers Research Focus:Evaluationandcharacterizationoftherapeutic CLINICAL RADIOLOGY RESEARCH ASSOCIATEPROFESSOROFRADIOLOGY/ Jeffrey Yap,PhD(ET) and acutemyeloidleukemiatreatment including transgenicmousemodelforpancreaticcancertreatment Research Focus:Newcombinationonseveralanimalmodels, PHARMACEUTICAL CHEMISTRY RESEARCH PROFESSOROFPHARMACEUTICSAND Jiyuan Yang,PhD(NPA) agriculture, andforensics medicine, cancer,infectiousdisease,populationbiology, Research Focus:Computationalgenomicstoolsforpersonalized H.A. ANDEDNABENNINGPRESIDENTIALENDOWEDCHAIR PROFESSOR OFHUMANGENETICS Mark Yandell,PhD(CCPS) health outcomes and designinginterventionstoimproveself-management health self-managementwithinpediatriconologypopulations, Research Focus:Psychologicalandbehavioralfactorsimpacting PREVENTIVE MEDICINE/PUBLICHEALTH ASSISTANT PROFESSOROFFAMILYAND Yelena Wu,PhD,MA(CCPS) regulaton ofsuccinatedehydrogenase Research Focus:Molecularpathwayforthebiogenesisand PROFESSOR OFMEDICINE/HEMATOLOGY/BMT Dennis Winge,PhD(NC) differentiation andcellfatedecisionsofactivatedTcellsinvivo Research Focus:Cellularandmolecularsignalsthatregulatethe MICROBIOLOGY ANDIMMUNOLOGY ASSISTANT PROFESSOROFPATHOLOGY/ Matthew Williams,PhD(CRR) NUCLEARCONTROLOFCELLGROWTH AND NON-PROGRAMALIGNED CELLRESPONSEANDREGULATION PROGRAM CANCERCONTROL AND POPULATIONSCIENCESPROGRAM

4. 3. 2. ClickSpecialGroupPlates. 1. Gotodmv.utah.gov. specialty licenseplate. Huntsman CancerInstitute fund cutting-edgesciencewitha Show ourcommunityyouhelp even faster. Help driveresearch HERE’S HO then followtheinstructions. Invite yourfamilyand friendstohelp Select CancerResearch, drive cancerresearch. CHANGING THE DNA OFCANCER CARE 0000C W

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61 APPENDIX 62 APPENDIX genetic counselors,andsocialworkerswhomeetforweeklypatienttreatmentplanningconferences. Multidisciplinary DiseaseGroups(MDGs)includespecialistssuchasphysicians,surgeons,researchers, Multidisciplinary DiseaseGroup(MDG)Leaders OF SURGERY ASSOCIATE PROFESSOR Jason Hunt,MD HEAD AND NECKMDG OF MEDICINE ASSOCIATE PROFESSOR Neeraj Agarwal,MD GENITOURINARY MDG PROFESSOR OFMEDICINE John Sweetenham,MD MEDICAL DIRECTOR EXECUTIVE

PROFESSOR OFMEDICINE Daniel Couriel,MD HEMATOLOGY/BMT MDG OF SURGERY ASSOCIATE PROFESSOR Christopher Dechet,MD PROFESSOR OFMEDICINE Saundra Buys,MD BREAST MDG

PROFESSOR OFMEDICINE Michael Deininger,MD,PhD RADIATION ONCOLOGY PROFESSOR OF David Gaffney,MD,PhD GYNECOLOGICAL MDG PROFESSOR OFSURGERY Edward Nelson,MD PROFESSOR OFMEDICINE Martha Glenn,MD AND GYNECOLOGY PROFESSOR OFOBSTETRICS Andrew Soisson,MD PROFESSOR OFSURGERY Courtney Scaife,MD PANCREATIC MDG GASTROINTESTINAL/

PROFESSOR OFSURGERY R. LorRandall,MD SARCOMA MDG PROFESSOR OFNEUROSURGERY William Couldwell,MD,PhD NEURO-ONCOLOGY MDG(CONT.) PROFESSOR OFMEDICINE Sunil Sharma,MD THERAPEUTICS MDG INVESTIGATIONAL PROFESSOR OFMEDICINE Anna Beck,MD AND SURVIVORSHIP MDG SUPPORTIVE ONCOLOGY PROFESSOR OFNEUROSURGERY Randy Jensen,MD,PhD OF SURGERY ASSOCIATE PROFESSOR Robert Andtbacka,MD SKIN MDG Multidisciplinary DiseaseGroup(MDG)Leaders

PROFESSOR OFMEDICINE Wallace Akerley,MD THORACIC MDG OF DERMATOLOGY ASSOCIATE PROFESSOR Glen Bowen,MD

OF SURGERY ASSOCIATE PROFESSOR Thomas Varghese,MD PROFESSOR OFNEUROSURGERY Howard Colman,MD,PhD NEURO-ONCOLOGY MDG

63 APPENDIX 64 APPENDIX together laboratory, clinical,andpopulationscientistswithexpertiseinspecificdiseaseareas. Disease-Oriented Research Teams (DOTs) supportcollaborationandadvancementsbybringing Disease-Oriented Research Team (DOT)Leaders PROFESSOR OFSURGERY Robin Kim,MD WORKING GROUP HEPATOBILIARY CANCERS OF SURGERY ASSOCIATE PROFESSOR Will Lowrance,MD,MPH MALIGNANCIES DOT(CONT.) GENITOURINARY PROFESSOR OFMEDICINE Michael Deininger,MD,PhD TRANSDISCIPLINARY RESEARCH SENIOR DIRECTOR

OF SURGERY ASSOCIATE PROFESSOR Robert Andtbacka,MD MELANOMA DOT OF MEDICINE ASSOCIATE PROFESSOR Thomas O’Hare,PhD HEMATOLOGIC MALIGNANCIESDOT OF MEDICINE ASSOCIATE PROFESSOR Ignacio Garrido-Laguna, COLON CANCERDOT

MD, PhD HEALTH SCIENCES PROFESSOR OFPOPULATION Cornelia Ulrich,PhD PROFESSOR OFDERMATOLOGY Doug Grossman,MD,PhD PROFESSOR OFPEDIATRICS Elizabeth Raetz,MD RADIATION ONCOLOGY ASSOCIATE PROFESSOROF Jonathan Tward,MD,PhD OF SURGERY ASSOCIATE PROFESSOR Sheri Holmen,PhD PROFESSOR OFMEDICINE Paul Shami,MD MALIGNANCIES DOT GENITOURINARY

AND PREVENTIVEMEDICINE ASSOCIATE PROFESSOROFFAMILY Mia Hashibe,PhD UPPER AERODIGESTIVE TRACTDOT(CONT.) PROFESSOR OFSURGERY Courtney Scaife,MD (CONT.) PANCREATIC CANCERDOT PROFESSOR OFNEUROSURGERY Howard Colman,MD,PhD NEURO-ONCOLOGY DOT OF SURGERY ASSISTANT PROFESSOR Marcus Monroe,MD PROFESSOR OFSURGERY R. LorRandall,MD SARCOMA DOT PROFESSOR OFNEUROSURGERY Randy Jensen,MD,PhD Disease-Oriented Research Team (DOT)Leaders

PROFESSOR OFMEDICINE Nicola Camp,PhD WOMEN’S CANCERSDOT PROFESSOR OFRADIOLOGY RESEARCH ASSOCIATE Jeffrey Yap,PhD PROFESSOR OFSURGERY RESEARCH ASSOCIATE Matthew Firpo,PhD PANCREATIC CANCERDOT RADIATION ONCOLOGY PROFESSOR OF David Gaffney,MD,PhD PROFESSOR OFMEDICINE Wallace Akerley,MD TRACT DOT UPPER AERODIGESTIVE OF HUMANGENETICS ASSOCIATE PROFESSOR Charles Murtaugh,PhD

65 APPENDIX 66 APPENDIX Donors FOUNDING MEMBERS MARTINDALE, FOUNDERS T. ANDELIZABETH R. FOUNDATION, HARRY FAIRCHILD-MARTINDALE ERIE PLASTICS FOUNDATION EDWARD L.BURTON *CLEONE P.ECCLES SPENCER F.AND LISA ECCLES SPENCER ECCLES KRISTINE AND DAVID BURNETT KATIE ECCLESAND RANDAL QUARLES C. HOPEECCLESAND JOE ANDALEXANDRADWEK CRAIG ANDPAMELACORRY FLOYD COOPER MARY ANNEAND COMMUNICATIONS, INC. COMPLETE HEALTHCARE MICHAEL COLEMAN MR. THOMASW.COLE HOWARD ANDBETTYCLARK CIBA SPECIALTYCHEMICALS SAINTS FOUNDATION CHRIST OFLATTER-DAY THE CHURCHOFJESUS CHRISTENSEN BOYD ANDJEAN FOUNDATION E. WATKINSCHARITABLE C. SCOTTANDDOROTHY SARA S.BOYER H. ROGERAND *MARY HANSENBOESCHE BERTIN FAMILYFOUNDATION BERNHISEL DENISE E.ANDJACK BAUMSTARK FAMILY THE JOHNT. HAVEN J.BARLOW MR. AND*MRS. BANKERS TRUSTCOMPANY RUSSELL BALLARD ELDER ANDSISTERM. FOX AUERBACH *F. LEEAND*FRED FOUNDATION ASHTON FAMILY FAMILY FOUNDATION ARLEN B.CROUCH APPLIED TECHNOLOGY,INC. CHEMICAL, INC. AIR PRODUCTS& 3COM INDUSTRIES, LTD. AMERICAN PLASTICS KOKI ANDCHARLES AMIN, KLINTWORTH SKIP ANDKIMBERLY DIANE ANDMICHAELKERN LINDA ANDILANKAUFTHAL MS. BARBARAF.KAMPEN A. JOHNSONFAMILY THE CAROLM.ANDWESLEY M. JENNINGS ESTATE OFEDITH COMPANY, INC. JACOBSEN CONSTRUCTION THE J.PAULGETTYTRUST S. IVORY ELLIS R.ANDKATHRYN HEALTHCARE INTERMOUNTAIN THE IMPARTGROUP,INC. HOLDINGS INC. ICI AMERICAN *ALEX HURTADO *RAMONA AND HUBER MARY ANDFREDERICK AND ABIGAILHORNACEK JEFF, STACY,RYAN,TYLER, JOHN L.HINDS MR. THORNTONL.HILL HEVERT INDUSTRIES,INC. B. HENKELS MR. ANDMRS.JOHN EILEEN HEALY L. RUSSELLAND FOUNDATION HARRY S.SLOANE HARMSEN SHARON ANDRANDY PAUL R.AND*ANNC.GREEN GRANOFF PERRY ANDMARTIN ESTATE OFEVELYNGOOTEE GLAXO WELLCOME,INC. THOMAS ANDANNAGERRITY FOUNDATION DOLORES DORÉECCLES THE GEORGES.AND JAKE GARN SENATOR ANDMRS. P. GARDNER DR. ANDMRS.DAVID *DAVID FREED *BLANCHE AND FRANKLIN COVEYCO. FLUOR ENTERPRISES,INC. & LOUGHRAN FINKELSTEIN, THOMPSON SWEET FAMILY THE R.ANTHONY SEATON PRINCE, JR. MR. ANDMRS.F. *BARBARA B.PRINCE PRESCOTT, MD SUSAN ANDSTEVE *MS. LARUEOLSEN COMPANY OKLAND CONSTRUCTION O. C.TANNERCOMPANY (UKRAINE) STYROL CONCERN NIKOLAY YANKOVSKY- ASSOCIATION NATIONAL BASKETBALL MR. ANDMRS.THOMASMUIR FRED ANDLUCYMORETON JOHN MORGAN MR. ANDMRS. BY JOHNA.MORAN EDWARD MORAN,GIVEN IN HONOROFBENJAMIN MORRIS FOUNDATION THE MITCHELLANDJUNE D. MELLOTT MR. ANDMRS.JOHN MR. LOUISJ.MARSCHAK WILLIAM MADSEN NANCEE AND FRANCIS MADSEN CONSTANCE AND MCCOMAS MARIE ANDMURRAY GIVEN BYHISFAMILY KEARNS MCCARTHEY, IN MEMORYOFTHOMAS *SUSAN A.MARTIN MARSH USA,INC. KARL ANDKAYMALONE *COACH RICKMAJERUS M. HOLLANDCOMPANY STEVEN J.LUND MR. ANDMRS. MS. NANCYLIEBERMAN H. WILLIAMLICHTENBERGER B. LENDALL ESTATE OFJAMES ROBERT LENCE ANN-MARIE AND E. LEE,MD DIANA W.AND*RICHARD *MERLINE CLARKLEAMING FRANK LAYDEN BARBARA AND AND MELISSAWEIDNER GERALD G.KRUEGER,MD *JEFFREY L.S.KOO FAMILY FOUNDATION SPENCER F.KIRK MARILYN SPAFFORD *R. STERLINGAND MS. JANNIESPADER NICHOLAS SMITH RYAN, SCOTT,AND JULIE ANDRICHIESMITH *IDA AND*DEESMITH SMITH FAMILY THE HYRUMANDGAIL SMITHKLINE BEECHAM GERALD SLOAN MR. ANDMRS. PUGMIRE-SKIDMORE AND CHRISTINE *LEE S.SKIDMORE DAN C.SIMONSFAMILY P. SIMMONS HARRIS H.ANDAMANDA MARJORIE T.SHARP DR. HOWARDC.ANDMRS. SAMUEL D.SCRUGGS JANET M.SCHAAP BERTRAM H.AND FOUNDATION THE SANFRANCISCO SALOMON SMITHBARNEY RUBICON, INC. *EVELYN ROSENBLATT *JO ANDJ.MARKROSE CHERE ANDJOHNROMNEY ROCKY MOUNTAINPOWER HAZEL M.ROBERTSON FOUNDATION THE ROBERTI.WISHNICK RINGWOOD ROSALIE ANDMICHAEL F. RIGBY,MD JOY W.ANDODELL MR. ANDMRS.BRIANRIDD RICH ANDFAMILY *JASMINE FREED DR. J.CHARLESAND GIVEN BYHISFAMILY OF BENE.RAWLINGS ∞IN LOVINGMEMORY STEPHEN M.RAWLINGS RANDALL M.RAWLINGS MARY LOUISERAWLINGS R. SCOTTRAWLINGS DAVID B.RAWLINGS HUNTSMAN MICHELLE RAWLINGS JULIE RAWLINGSBAGLEY ANDERSON MARILEE RAWLINGS DONORS ASOF9/29/2016 $1,000,000 + BENEFACTORS EMPLOYEES HUNTSMAN CORPORATION HUNTSMAN CORPORATION ∞GLAXO WELLCOME,INC. ECCLES FOUNDATION AND DOLORESDORÉ ∞THE GEORGES. PAULSON 1997UNITRUST THE *GEORGEAND*SHAREE LOU FULTON IRA A.AND*MARY FOUNDATION THE FOSTERCHARITABLE ∞FLUOR ENTERPRISES,INC. DESERET POWER RESEARCH FOUNDATION DAMON RUNYONCANCER CHILDREN’S CANCER CURESEARCH FOR SAINTS FOUNDATION CHRIST OFLATTER-DAY ∞THE CHURCHOFJESUS RON AND*JACKIEBOONE OF AMERICA BEAUMONT FOUNDATION RUSSELL BALLARD ∞ELDER ANDSISTERM. ARMY MEDICALRESEARCH SOCIETY, INC. AMERICAN CANCER KHALID ANDSALLYALTURKI JAMES PACKER THE KERRYPACKERFAMILY ESTATE OFOLIVES.YOUNG PROPERTY LIMITED ROBERT WHYTE-AUDANT WINTERFELD GAIL ANDCURTIS KENNETH L.WILLIAMS WHEELWRIGHT STEVEN ANDMARGARET KAREN ANDSTEVENWEST VANGUARD MEDIA CORNWALL &MCCARTHY VAN COTT,BAGLEY, AND FAMILY *MARY LOUUNICE TOIMOTO HARU AND*ARTHUR TERRY ANDJAMESTAYLOR SUN MICROSYSTEMS STEVENSON MARGO ANDBRENT SANDY ANDDONSTANUTZ ∞FOUNDING MEMBER

*DECEASED SIGMA CHICHAPTERS FOUNDATION THE RAY&TYE NOORDA T. MAINTRUST ∞RALPH E.ANDWILLIA QUALTRICS, INC. PRA INTERNATIONAL PI FOUNDATION ANNA PERINE IN MEMORYOFTERRI SCIENCE UNIVERSITY OREGON HEALTHAND SUSAN NOORDA ANDY NOORDA DISORDERS ANDSTROKE OF NEUROLOGICAL NIH NATIONALINSTITUTE AND KIDNEYDISEASES DIABETES ANDDIGESTIVE NIH NATIONALINSTITUTEOF CRANIOFACIAL RESEARCH OF DENTALAND NIH NATIONALINSTITUTE INSTITUTE ONAGING NIH NATIONAL MEDICAL SCIENCES INSTITUTE OFGENERAL NIH NATIONAL HUMAN DEVELOPMENT OF CHILDHEALTHAND NIH NATIONALINSTITUTE AND SKINDISEASES MUSCULOSKELETAL OF ARTHRITISAND NIH NATIONALINSTITUTE INSTITUTE NIH NATIONALCANCER MORRIS FOUNDATION ∞THE MITCHELLANDJUNE *LARRY ANDGAILMILLER MICHE BAG,LLC MEMORIAL FUND AND LADEANR.WORTON THE MATHEWB.WORTON BY *GAYEMARRASH PHILIP ALFORD,GIVEN IN LOVINGMEMORYOF *GAYE MARRASH SURGEON, GIVENBY MD, CARDIOVASCULAR SAMIR E.MARRASH, IN LOVINGMEMORYOF FOUNDATION MAJERUS FAMILY THE LINCYFOUNDATION LYMPHOMA SOCIETY LEUKEMIA AND S. MARRIOTTFOUNDATION THE J.WILLARDANDALICE HEALTHCARE ∞INTERMOUNTAIN $500,000 -$999,999 PATRONS HEALTH POLICY HRSA RURAL ROBERT GAY,PHD LYNETTE AND P. GARDNER ∞DR. ANDMRS.DAVID CHARITABLE FUND FIDELITY INVESTMENTS DEUTSCHE BANK CTBC BANK CUMULUS CHARITIES OFUTAH COMMUNITY HEALTH COLUMBIA UNIVERSITY CHEMICALS ∞CIBA SPECIALTY WILLIAM CHILD PATRICIA AND INSTITUTE OFCALIFORNIA CANCER PREVENTION FOUNDATION E. WATKINSCHARITABLE ∞*C. SCOTTANDDOROTHY ∞*MARY HANSENBOESCHE FOUNDATION ∞BERTIN FAMILY *JIM S.BATEMAN STAND FOUNDATION ALEX’S LEMONADE ANONYMOUS ZIONS BANK CHARITABLE FOUNDATION WILLARD L.ECCLES NICHOLS, ANDNOELLE KEITH, AMY,SABRINA, THE VANHORNFAMILY AND DOROTHYMOSS THANKS TO*LARRY JR. TRUSTWITHSPECIAL THOMAS C.MATHEWS CANCER FOUNDATION SUSAN G.KOMENBREAST *ELEANORE STEELE *HAROLD AND STATE OFUTAH FAMILY FOUNDATION ∞SPENCER F.KIRK ONCOLOGY GROUP SOUTHWEST NICHOLAS SMITH ∞RYAN, SCOTT,AND ∞JULIE ANDRICHIESMITH ∞*IDA AND*DEESMITH

$250,000 -$499,999 GUARANTORS OF *JAMESWILCOX IN LOVINGMEMORY ETHEL ANDCARL DEFOSSE, GORDON D.COOK VIRGINIA AND CLISE FAMILY PAUL E.BROWN LYNDA ANDGARYBRIDGE DORIS M.BOMGARDNER DIANN BENDER BARTHOLOMEW KAREN ANDBRENT JAMES CARLALLEN ANONYMOUS (UKRAINE) STYROL CONCERN ∞NIKOLAY YANKOVSKY- WON-DOOR CORPORATION THE WIGGINSFAMILY VLCM FOUNDATION OF DEFENSE U.S. DEPARTMENT TEE ITUPFOUNDATION SWALLOW ESTATE OF*HELEN RON ANDJODIESMART THE SDAFOUNDATION COLLABORATION RESEARCH THROUGH SARCOMA ALLIANCEFOR ∞SALOMON SMITHBARNEY ROBINSON MARSHA ANDBLAKE *BEN E.RAWLINGS ∞MARY LOUISEAND FURNISHINGS R.C. WILLEYHOME FOUNDATION R. HAROLDBURTON PINNACLE ENTERTAINMENT PAREXEL INTERNATIONAL INSTITUTE GENOME RESEARCH NIH NATIONALHUMAN & COMPANY,LLC MILLER BUCKFIRELEWIS THE LAYTONCOMPANIES DAVID ANDJULIELAYTON KLINTWORTH ∞SKIP ANDKIMBERLY KJZZ 14 HEALTH CENTER INSTITUTE ATST.JOHN’S JOHN WAYNECANCER Donors

67 68 APPENDIX Donors *BETH NIELSON CAROL A.NANTKES DAVID ANDTERRIE MOSS MONTAGUE ANTHONY ANDJULIA EAGLETON-MITCHELL AND JEANMARIE MICHAEL MITCHELL TAYLOR MILLER DAVID MCGUIRE EDITH MCGOVERN GREG L.MCEWAN SIDNEY MCDONALD *GAYE H.MARRASH MARGETTS SIR ROBANDLADY JULIE LOCKEY SARAH ANDGEORGELEWIS MILTON ANDKAYLARSEN MRS. RUTHKURZBAUER MR. DONALDKALMAN ENDOWED FUND RICHARD WHITLOCK THE JUDYKELLYAND REMAINDER UNITRUST DIMICK CHARITABLE JOEL R.ANDLISA RICK JANY MARTHA ANDCRAIGHEATH HAYDEN NANCY ANDROBERT CINDY ANDWYATTHAWS AND SUSANBOESCH GEOFFREY HASSAN HARGREAVES, MD *HAROLD P. MARY HADLEY DOUGLAS AND HER HUSBANDKEITH IN LOVINGMEMORYOF MRS. JUDYGRUENBERG, SUSAN GREENDORFER GREENBERG CHRISTINA ANDMICHAEL PAUL R.AND*ANNC.GREEN LOWELL ANDJERRYGLASS CRAIG GILBERT MR. ANDMRS.JAMES DR. WILLIAMM.GASSERT STEVE FREDRICKSON UNITRUST CHARITABLE REMAINDER FREDERIKA HARLIN CAROL M.FAY RICHARD A.AND PAMELA DROPEK RICHARD AND $250,000 -$499,999 PLATINUM IBM CORPORATION RAE ANNHAMILTON DAVID B.HAIGHT *ELDER AND*SISTER EPIC EVENTS JOSEPH DWEK ∞ALEXANDRA AND DESERET NEWS DELTA AIRLINES,INC. DELOITTE CISCO SYSTEMS CENTURYLINK THE BOSTONFOUNDATION BONNEVILLE CYCLINGCLUB GLENN ANDTANIABECK FOUNDATION, INC. BANK OFAMERICA AND MATERIALCOMMAND ARMY MEDICALRESEARCH FOUNDATION ANNE STIRBACANCER ASSOCIATION AMERICAN DIABETES FOUNDATION ALAN B.SLIFKA ANONYMOUS JAMES B.WOOD J. ANDJOANNEWILLIAMS ASSOCIATION WESTERN BOYSBASEBALL *NORRIS WEIMER TOIMOTO HARU AND*ARTHUR KATHY ANDTOMTANGNEY RAYMOND WRIGHT MEMORY OFLOUIS JANCE STUESSI,INLOVING LAURA ANDALBERTSPICER *JAY A.AND*RUTHR.SMART JOAN ANDROBERTSELL JANET M.SCHAAP *BERTRAM H.AND ANTOINETTE M.RUTH NORMA ROHDE JOYCE AND*ROBERTL.RICE LIFETIME TRUST *RICHARD E.ELLISON *CAROLYN REINBOLD JOHN A.REED A. PHILLIPS IN HONOROFLOTTIE CHARLOTTE A.PHILLIPS,

$100,000 -$249,999 GOLD ACTION DONATIONS ∞3COM ANONYMOUS SERVICES COMPANY ZIONS MANAGEMENT S. YOUNG ∞ESTATE OFOLIVE VINSON &ELKINS,LLP VALUEMOMENTUM CANCER RESEARCH V FOUNDATIONFOR AT HOUSTON UNIVERSITY OFTEXAS CALIFORNIA SANDIEGO UNIVERSITY OF PANOS FOUNDATION THE TOMANDWILMA FOOD SERVICES,INC. SYSCO INTERMOUNTAIN SWING FORLIFE,INC. FOUNDATION ST. BALDRICK’S SOLUTIONS USA,INC. SIEMENS MEDICAL *FRANK W.RENALD REAUD FAMILYFOUNDATION PETERSON *V. MARKAND*NANCY PEARSON EDUCATION FOUNDATION PLAYING FORLIFE *CHARLES A.OLIVERIO FOUNDATION THE OKLANDFAMILY COMPANY ∞OKLAND CONSTRUCTION AND SKINDISEASES MUSCULOSKELETAL OF ARTHRITISAND NIH NATIONALINSTITUTE JOY ANDDONNELSON MCCARTHEY SANDRA ANDPHILIP MAYO CLINICROCHESTER STEVEN J.LUND ∞MR. ANDMRS. INITIATIVE FUND LIDDY SHRIVERSARCOMA *SHEILA A.LEE ∞*MERLINE CLARKLEAMING KAHLERT FOUNDATION ∞THE J.PAULGETTYTRUST ICON CLINICALRESEARCH

*CLEONE PECCLES ∞SPENCER F.AND JAMES L.EASTON DURHAM ANDFAMILY RICHARD ANDCHRISTENA EZEKIEL R.DUMKEJR. *KATHERINE W.AND FOUNDATION EDNA WATTISDUMKE DR. EZEKIELR.& DEVINE RACING,LLC FOUNDATION OFAMERICA CROHN’S ANDCOLITIS WILL CRENSHAW CREDIT SUISSE FLOYD COOPER ∞MARY ANNEAND CHARITIES OFAMERICA COMMUNITY HEALTH COMCAST CODALE ELECTRICSUPPLY CLOVIS ONCOLOGY C. CLARKJR. ESTATE OF*JOSEPH CORBIN ANDKARACHURCH CHIMERIX, INC. OSCAR CANTU C.R. ENGLAND,INC. FRASER BULLOCK JENNIFER AND BRISTOL-MYERS SQUIBB SARA S.BOYER ∞H. ROGERAND FOUNDATION TRUST THE BOYERFAMILY BOBETTE ANDVANBOHNE GROUP BENEFICIAL FINANCIAL FOUNDATION, INC. BARKER FAMILY COMPANY ∞BANKERS TRUST AUTOLIV CYCLINGCLUB DELOITTE FOUNDATION ∞ASHTON FAMILY ASGAARD ENTERTAINMENT REVOCABLE TRUST ANITA W.BETZ FOUNDATION ANDERS H.BERGVIND AMGEN, INC. OF HEMATOLOGY AMERICAN SOCIETY GASTROENTEROLOGY AMERICAN COLLEGEOF ALLIANCE HEALTH DONORS ASOF9/29/2016 FOUNDATION MARRINER S.ECCLES DEFECTS FOUNDATION MARCH OFDIMESBIRTH MANCINI JANET ANDVINCENT ∞KAY ANDKARLMALONE *GLADYS MADSEN SUSAN ANDROBERTKIMSEY LISA ANDJEFFREYKELLOGG KELEZ FAMILY ROBERT ANDANITA JOHNS HOPKINSUNIVERSITY FOUNDATION, INC. JEANNE &JOELLEFF KATHRYN S.IVORY ∞ELLIS R.AND FREDERICK QUINN RET. ANDREVEREND CAROLYN TANNERIRISH, THE RIGHTREVEREND HOLDINGS, INC. ∞ICI AMERICAN HUNTSMAN PETER ANDBRYNN JON M.HUNTSMANJR. GOVERNOR ANDMRS. HUNTSMAN DAVID ANDMICHELLE SENIOR GAMES,INC. HUNTSMAN WORLD HORNACEK TYLER, ANDABIGAIL ∞JEFF, STACY,RYAN, FOUNDATION HELEN HAYWHITNEY PUBLIC HEALTH HARVARD SCHOOLOF FOUNDATION ∞HARRY S.SLOANE CHARITABLE TRUST HARRY J.LLOYD LOY HANSEN MR. ANDMRS.DELL GRANOFF ∞PERRY ANDMARTIN GERRITY, PHD ∞ANNA ANDTHOMAS BLANCHE FREED ∞*DAVID L.AND OF EAGLES FRATERNAL ORDER COMPANY ∞FRANKLIN COVEY FOUNDATION FRANCES W.BURTON FIDELITY FOUNDATION FOUNDATION ELYSE PANTKEWHITE FOUNDATION ∞EDWARD L.BURTON ∞FOUNDING MEMBER

*DECEASED LORENE RUSSELL, FN,MS IN MEMORYOF NELL ∞*JO ANDJ.MARK ROSE RICHARD ROGERS CARMEN AND ∞ROCKY MOUNTAINPOWER ∞HAZEL M.ROBERTSON RICH ANDFAMILY MRS. *JASMINEB. ∞DR. J.CHARLESAND FOUNDATION THE OREGONCOMMUNITY THE REGENCEFUNDOF BLUESHIELD OFUTAH REGENCE BLUECROSS CORPORATION QUINTILES TRANSNATIONAL FOUNDATION PROSTATE CANCER FOUNDATION PROGERIA RESEARCH ROUNDTABLE THE PHILANTHROPY PETERSON JONIQUE AND*TIG MARY ANDJEFFPETERSON PACIFICORP B. OSTLER O. DONANDBARBARA *MARCIA OLCH GORDON AND ∞O. C.TANNERCOMPANY FOUNDATION NOREEN FRASER ASSOCIATION ∞NATIONAL BASKETBALL FOUNDATION MPN RESEARCH CREDIT UNION MOUNTAIN AMERICA MORRIS *JOHN ANDMARGARET BY JOHNA.MORAN EDWARD MORAN,GIVEN ∞IN HONOROFBENJAMIN MOFFITT CANCERCENTER COMPANY, INC. MERRILL LYNCH& FAMILY TRUST THE MELANIELARSEN GIVEN BYHISFAMILY KEARNS MCCARTHEY, ∞IN MEMORYOFTHOMAS FOUNDATION MCCARTHEY FAMILY ALLIANCE MELANOMA RESEARCH LISA ANDDAVIDMATLIN FOUNDATION MARRIOTT DAUGHTERS $50,000 -$99,999 SILVER HAVEN J.BARLOW ∞MR. AND*MRS. DARLA ANDMIKE ASSMAN COMPANY ARNOLD MACHINERY TECHNOLOGY, INC. ∞APPLIED ANDERSON MARILEE ANDBOYD AMES CONSTRUCTION,INC. ENDOSCOPY GASTROINTESTINAL AMERICAN SOCIETYFOR ANONYMOUS YM BIOSCIENCES,INC. FOUNDATION AND BLANCHEHUGHES THE WILLIAMLAWRENCE HEWLETT FOUNDATION THE WILLIAMANDFLORA PROPERTY LIMITED ∞ROBERT WHYTE-AUDANT IN ST.LOUIS WASHINGTON UNIVERSITY THE WALBRIDGEFUND,LTD. VIVINT SMARTHOMEARENA UTAH STATEUNIVERSITY FOUNDATION UTAH SPORTSCOMMISSION SHELDON URLIK SANDRA AND RESEARCH FOUNDATION UNIVERSITY OFUTAH UNIVERSITY OFMICHIGAN UNIVERSITY OFCINCINNATI MEDICAL CENTER SOUTHWESTERN UNIVERSITY OFTEXAS UNIVERSITÉ LAVAL ANITA M.TROTTER-COX THRASHER RESEARCHFUND STEIN ERIKSENLODGE SINCLAIR OILCORPORATION UNIVERSITY GEORGE WASHINGTON SIGMA CHIEPSILON- UNIVERSITY OFUTAH EPSILON CHAPTER- SIGMA CHIBETA RESEARCH FOUNDATION SAMUEL WAXMANCANCER 2002 OLYMPICS COMMITTEE WINTER SALT LAKEORGANIZING MAX T.SABOUR

INTERFORM GRAPHICS INFILISE HOLDINGS, INC. HUNTSMAN *BLAINE ANDNANCY HOPE STREETKIDS ∞JOHN L.HINDS HGGC RANDY HARMSEN ∞SHARON AND ELAINE ANDBARRYHARMAN PAM ANDSCOTTHALE *ANN C.GREEN ∞PAUL R.AND SUSAN ANDEVANGOODWIN CANCER GOLF TOERADICATE JOHN A.GODFREY GIBBS &BRUNS,LLP GARDNER CAROLYN ANDKEM TAMMY ANDJAMESFELT FASSIO EGGFARMS,INC. FAIRWAYS MEDIA MARTINDALE, FOUNDERS T. ANDELIZABETHR. FOUNDATION, HARRY ∞FAIRCHILD-MARTINDALE MAZILE ENGLAND *MARY B.ELICH EAGLE EYEPRODUCE,INC. ROSS E.DOAN DIXIE POWER PATEL FOUNDATION DINESH &KALPANA CHRISMAN BARBARA ANDBILL CLISE FAMILY BETTY CLARK ∞HOWARD AND FOUNDATION CAMBIA HEALTH BURNINGHAM DALE ANDJANEEL CANCER AGENCY BRITISH COLUMBIA FOUNDATION OFALABAMA BREAST CANCERRESEARCH CORPORATION INTERNATIONAL BONNEVILLE COMPANY BOART LONGYEAR BIOMET BERGESON *ELAINE ANDSCOTT BEN BARNES Donors 69 70 APPENDIX Donors CHRIS PECHOCK ELIZABETH AND PAUL NABILBUSTANY FUND DAVID PARKIN JENNIFER AND L. PARKIN,MD BONNIE ANDJAMES OLIVERIO *NANCY ANDANTHONY JEANNE OKI FOUNDATION NORA ECCLESTREADWELL NIKE GOLF PARTNERSHIP N &BFAMILYLTD. MYRIAD GENETICS,INC. INFORMATION RESEARCH AND FOR BRAINTUMOR MUSSELLA FOUNDATION ∞FRED ANDLUCYMORETON AND SUPPORT,INC. METAVIVOR RESEARCH MERIT MEDICALSYSTEMS JOHN D.MELLOTT ∞MR. ANDMRS. FOUNDATION MELANOMA RESEARCH PRODUCTS, INC. MEGADYNE MEDICAL DAN W.MCKNIGHT KATHY ANDTONYMCCORD MCCOMAS ∞MARIE ANDMURRAY NEAL H.MAYERSON ∞MARSH USA,INC. KIDS CANCERFOUNDATION MAKE SOMENOISE:CURE ∞*COACH RICKMAJERUS MAGGIE SOTTERODESIGN MACY’S FOUNDATION LOW BOOKSALES LICHTENBERGER ∞H. WILLIAM CORPORATION LEUCADIA NATIONAL LAMBERT BRENT ANDCHRISTIE KRYSTKOWIAK LARRY ANDJANEENE KRISHNAN AJAY ANDSHAILAJA *CONRAD J.KNOWLES,MD M. JENNINGS ∞ESTATE OFEDITH COMPANY, INC. CONSTRUCTION ∞JACOBSEN STATE UNIVERSITY DELTA -OKLAHOMA SIGMA CHIGAMMA SOUTHERN UNIVERSITY CHAPTER -GEORGIA SIGMA CHIETAZETA - UNIVERSITYOFTULSA SIGMA CHIDELTAOMEGA OF DENVER CHAPTER -UNIVERSITY SIGMA CHIDELTAIOTA UNIVERSITY OFTEXAS SIGMA CHIALPHANU- STATE UNIVERSITY CHI -PENNSYLVANIA SIGMA CHIALPHA VIRGINIA E.SHANKS OF AMERICA SARCOMA FOUNDATION ∞SAMUEL D.SCRUGGS JANET M.SCHAAP ∞*BERTRAM H.AND SANFILIPPO ANGELA ANDANTHONY MARRIOTT DOWNTOWN SALT LAKECITY SAGGURTI SHRIDEVI ANDPURNA CARLOS RUISANCHEZ ∞RUBICON, INC. HELENE AND*ALVINRICHER JOYCE AND*ROBERTL.RICE GIVEN BYHISFAMILY OF BENE.RAWLINGS ∞IN LOVINGMEMORY SWEET FAMILY ∞THE R.ANTHONY QUESTAR SEATON PRINCEJR. ∞*MR. ANDMRS.F. PRESCOTT, MD ∞SUSAN ANDSTEPHEN FOUNDATION MEDICAL CENTER PRIMARY CHILDREN’S POPP HUTCHESON,PLLC DEVELOPMENT, INC. PHARMACEUTICAL PRODUCT THE PEERYFOUNDATION STEPHEN M.RAWLINGS RANDALL M.RAWLINGS MARY LOUISERAWLINGS R. SCOTTRAWLINGS DAVID B.RAWLINGS HUNTSMAN MICHELLE RAWLINGS JULIE RAWLINGSBAGLEY ANDERSON MARILEE RAWLINGS FOUNDATION WHEELER FAMILY WEBSTER LESLEY ANDWAYNE FOUNDATION THE WATTLESFAMILY NICHOLAS WARD NANCY AND *JANE WAGNER BONNIE ANDNATEWADE UNIVERSITY OFULSTER SAN FRANCISCO UNIVERSITY OFCALIFORNIA BRITISH COLUMBIA UNIVERSITY OF AT BIRMINGHAM UNIVERSITY OFALABAMA UNITED WAYOFSALTLAKE TOIMOTO ∞HARU AND*ARTHUR JUDY ANDLARRYTILLERY SHARON K.THOMPSON SKOLNICK FOUNDATION TORRES, GIVENBYTHE IN HONOROFMARIAA. TANZI, USAF,RET. MAJOR GENERALDAVID COMPUTER CORPORATION ∞SUN MICROSYSTEMS STORM PRODUCTS,INC. GARDNER FOUNDATION STERLING ANDSHELLI STAMPIN’ UP! MARY S.SOUVALL SORENSON DEVELOPMENT SOCCER FORHOPE KAREN ANDSCOTTSMITH BOYD C.ANDJILLJ.SMITH FOUNDATION SMILES FORLIFE DOROTHA SMART GERALD SLOAN ∞MR. ANDMRS. MEAGHER &FLOM,LLP SKADDEN, ARPS,SLATE, GROUP, INC. SINCLAIR BROADCAST AMANDA P.SIMMONS ∞HARRIS H.AND ARIZONA UNIVERSITY OMICROM -NORTHERN SIGMA CHIZETA KENTUCKY UNIVERSITY CHAPTER -WESTERN SIGMA CHIZETAMU NORTHERN FLORIDA BETA -UNIVERSITYOF SIGMA CHIKAPPA $10,000 -$49,999 FRIENDS TECHNOLOGY, INC. AMERICOM INSURANCE COMPANY AMERICAN FAMILYMUTUAL INSURANCE AMERICAN FAMILY PHILANTHROPIC PROGRAM AMERICAN EXPRESS OF DERMATOLOGY AMERICAN ACADEMY CREDIT UNION AMERICA FIRST ALTUS ONEFUND,INC. KEITH ALLRED DAWN ALLRED SERVICE, INC. ALLEN SALES& AND JOHNALLEN PATRICIA HODGES CLAIRE H.ALLEN AND *JUNEALDOUS IN MEMORYOF*GORDON CARL ANDGAILALBRECHT ALBERTSON’S, INC. FOUNDATION TRUST ALBERT G.CLAYFAMILY AND ROBERTAWANG DRS. WALLACEAKERLEY CHEMICALS, INC. ∞AIR PRODUCTS& INTERNATIONAL, INC. AIR &SEA FOUNDATION AGILENT TECHNOLOGIES AGEL CARESFOUNDATION RAVI ADUSUMALLI CORPORATION ADMIRAL BEVERAGE CUTTING, INC. A-CORE CONCRETE FRIEDA ADAMSDOTTER ESTATE OFMARTHA 4NATHALIE ANONYMOUS INTERNATIONAL WREN ANDFIDA CO., INC. WOLLAM CONSTRUCTION WINTERFELD ∞GAIL ANDCURTIS ROMNEY ANDROSSWHITE SUSAN ANDRONALDWHITE DONORS ASOF9/29/2016

SUSAN ANDJAMES BLAIR FOUNDATION W. HARMONCHARITABLE BLAINE N.ANDBARBARA BIODISCOVERY, INC. BIKE2BIKE BETZ, MD ANN ANDA.LORRIS BESSEMER TRUST BERNHISEL ∞DENISE ANDJACK DANIEL L.BERMAN BEIJER ELECTRONICS *VERNON R.BEELER DAVID G.MURRELLIV MARY BECKERLE,PHDAND OF MEDICINE BAYLOR COLLEGE BAUMSTARK FAMILY ∞THE JOHNT. FOUNDATION BASTIAN FAMILY BONNIE BARRY BARRICK CHRISTOPHER J.BALFE PAM ANDJEFFBAILEY COMPANY OFHAWAII,INC. THE BADASSCOFFEE BABCOCK JUDITH ANDRUSSELL MARK BABBITT JEANETTE AND INC -CITYWORKS AZTECA SYSTEMS PHARMACEUTICALS, INC. AVENTIS ISAAC ANDDENISEAUSTIN FOX AUERBACH ∞*F. LEEAND*FRED ANGELA ATKIN ATHENA PARTNERS STORES, INC. ASSOCIATED FOOD CONTRACTORS, INC. ASSOCIATED BRIGHAM JO ASHLEY ESTATE OF*BILLIE FOUNDATION, INC. THE ARNOLDF.BAGGINS NEXUS, INC. ARCHITECTURAL CHARITABLE CORPORATION ARCHER FAMILY SCOTT ANDERSON JESSELIE ANDA. INDUSTRIES, LTD. AMIN, AMERICANPLASTICS ∞KOKI ANDCHARLES ∞FOUNDING MEMBER

*DECEASED AUSTIN CHILDERS REED CHIDESTER LYNETTE ANDJ. CHARITY FOLKS,INC. RIDES &SERVICES,INC. CHARITABLE ADULT BETH ANDSAMCHAPIN CENTURYLINK FAMILY TRUST CECIL C.WALL THE CASTLEFOUNDATION KAY ANDR.DONCASH RESERVE UNIVERSITY CASE WESTERN MEDICAL CENTER TAHOE REGIONAL HEALTH, DBA,CARSON CARSON TAHOEREGIONAL CAROL T.CARLSON PETE CARMODY YVONNE J.CARDWELL CANYON FINANCIAL,INC. INSTITUTE CANCER RESEARCH CAMPBELL SCIENTIFIC,INC. FOUNDATION CALIFORNIA COMMUNITY CACHE VALLEYELECTRIC FOUNDATION, INC. C. R.BARD BYU ATHLETICDEPARTMENT CHARLES C.BUTT *ANNA M.ANDELIOTBUTLER SCOTT BURTON BURTON SUSAN ANDRICHARD RANDALL BURT,MD MARJORIE AND STEVEN B.BURNS JEFF BULLOCK BRUNKEN CATHY ANDSTEPHEN BRIGHTON RETAIL ASSOCIATION, INC. BRIDGER VALLEYELECTRIC DREW BROWNING JUDY BRADYAND BORDEN, INC. COMMUNICATIONS BONNEVILLE BMW OFMURRAY EDUCATIONAL FOUNDATION BLUE ANDGOLD SHARI ANDKEITHBLOOM KIM ANDJASONBLEAK D &BMETALS,INC. KARAN ANDL.DEE CURTIS M. CUMMING ANNETTE ANDIAN FAMILY FOUNDATION ∞ARLEN B.CROUCH JOSEPH CRONLEY AND TOMLEONARD MARTHA CROCKER JAE ANDJERRYCRAMER CRABTREE TAMARA ANDDAVID COWBOY LEGENDS COURTESY CARCOMPANY JOHN COSTA CRAIG CORRY ∞PAMELA AND RAE B.COOMBS MARY ANDRICHARDCOOK DESIGNS, LTD. COLLEEN MALOUF FOUNDATION CONTINENTAL GRAIN CONSONUS, INC. COMMUNICATIONS, INC. ∞COMPLETE HEALTHCARE OF UTAH COMMUNITY VOLUNTEERS OF UTAH COMMUNITY FOUNDATION OF JACKSONHOLE COMMUNITY FOUNDATION FOUNDATION THE COLUMBUS COLONIAL MFG.INSULATION COLEMAN ∞JACKIE ANDMICHAEL ∞MR. THOMASW.COLE CMIC CLEARFIELD HIGHSCHOOL GROUP, INC. CLEANING SERVICES CLAYTON RHONDA ANDSCOTT DOUGLAS CLAUSEN GEORGIANA AND CONSULTING GROUP CLARKSTON SHAUNNA ANDRICKCLARK CHRISTENSEN DR. WILLIAMR. CHRISTENSEN ∞BOYD ANDJEAN LOUIS R.CHRISTENSEN *CAROL CHRISTENSEN ONCOLOGY GROUP CHILDREN’S DOWLING SHERYL ANDCHRIS COMPANY FOUNDATION THE DOWCHEMICAL ANN ANDSEANDOUGLAS FOUNDATION DOUGLAS N.THOMPSON SHONKWILER TRUST DOUGLAS C. TERRELL ANDPAULDOUGAN CHRISTINA J.DONELSON FOUNDATION DON KAYCLAYCASH MEMORIAL TRUST EVELYN K.DOBROSKI DJL ENTERPRISES DJB GASSERVICES,INC. ENTERPRISES DESERT OASIS DESERET TRUSTCOMPANY ORTHOPEDICS DEPARTMENT OF MEMORY OFMARYNORRIS FOUNDATION, INLOVING JOAN NORTONFAMILY THE DENNISAND FAMILY FOUNDATION SUSAN E.DENKERS THE STEPHENG.AND NANCY ANDMAXDELGADO DEGERING NICEA ANDSCOTT DEE’S INCORPORATED ANN ANDNEILDECKER H. DELAND ESTATE OF*LAWRENCE FINANCIAL SERVICES DE LAGELANDEN THE DAYSOF’47,INC. DAYNES MUSIC COUNCIL DAYBREAK COMMUNITY CENTER DAYBREAK COMMUNITY DAVIS SCHOOLDISTRICT LIVING TRUST DAVID S.DOLOWITZ REVOCABLE TRUST DAVID N.ROSE ALEXANDER DANOYAN LISA ANDANDREWDANIELS LISA ANDDAVIDDAME KARYN ANDMIKEDAMBACH MARC S.DALLACOSTA MARY AND*WELDENDAINES FLORA ANDJOHND’ARCY Donors 71 72 APPENDIX Donors CHARITABLE FOUNDATION ELIZABETH ALEX THE FRANKLINAND GALE R.FRANDSEN FOXLEY &PIGNANELLI CENTER FOX CHASECANCER FOUNDATION 4LIFE ASSOCIATION, INC. FLOWELL ELECTRIC FITZPATRICK, PHD AMELIA ANDFRANK JOAN ANDJOHNFIRMAGE & LOUGHRAN ∞FINKELSTEIN, THOMPSON FERGUSSON CARRI ANDDAN CYNTHIA F.FAYARD JOY ANDRICHARDFASSIO STEPHANIE FARIS DAVID AND EXLI CORP SNOWBOARD COMPANY EVOLUTION SKI& EUREKA CASINOHOTEL KAYE ANDJ.KIMOESPLIN ∞ERIE PLASTICS *RUSSELL E.ERICSON M. CATHAYERICSON ENTHEOS ACADEMY SUE J.ELLIS DEDUCTION TRUST ELLIOTT WOLFEMARITAL WHOLESALE SUPPLY ELECTRICAL EDWARDS DONNA E.AND*M.G. ED VICTORLIMITED SPENCER ECCLES ∞KRISTINE AND ∞LISA ECCLES DAVID BURNETT ∞KATIE ECCLESAND RANDAL QUARLES ∞C. HOPEECCLESAND EBAY FOUNDATION EAST MILLARDLIONS E TRADEFINANCIAL FAMILY TRUST E. FARLEYESKELSON ELAINE ANDIVANDYRENG DYKE’S ELECTRIC,INC. DURBANO METALS ROCKLAND DRAPER LANETT AND SALT LAKE,INC. HARRIS REBAR JOE W.HARRIS ANN ANDDELHARRIS CORPORATION HARLAND CLARKE HARKER DESIGN DARLENE ANDTOMHARE HOLLY ANDAARONHARDY HANWATANANUGOOL PRAMOT ASHLEY ANDNEILHAFER THE HACKETTGROUP,INC. BENEVOLENT CORPORATION THE H.R.WINGFAMILY SUSAN L.GREENDORFER ROBERT SCHACKMAN,PHD BARBARA GRAVES,PHDAND OES OFUTAH GRAND CHAPTER GOOTEE ∞ESTATE OFEVELYN & COMPANY GOLDMAN, SACHS DAVID GOLDGAR CONSTANCE AND GODDARD JOHN AND*GERALDINE J. KELLYGODDARD KATHY ANDNEWMANGILES BARBARA GICQUEL OPERATING FUND GETTYSBURG COLLEGE JANIE ANDDEANGESTAL GENESEE &WYOMING,INC. GE FOUNDATION MRS. JAKEGARN ∞SENATOR AND GARKANE ENERGY,INC. KATHARINE GARFF ROBERT AND GARFF ENTERPRISES,INC. ERNESTO GAMONAL SHIRLEEN AND FUEL FORTHEFIGHT FROSTEE TREEFARM *BONNIE FRONCE *DONALD B.AND LYNN ANDFOSTERFRIESS FRIENDS OFMIKELEE,INC. SPA, INC.NEWORLEANS FRENCH RIVIERAHEALTH FREEDOM BLAST,LLC FOUNDATION FREDRICK H.BARTH HUTCHISON DEANNE ANDTHOMAS *ALEX HURTADO ∞*RAMONA AND HUNTSMAN LLC FOUNDATION HULLINGER FAMILY DRUE ANDALANHUISH BRIAN HUGGARD FREDERICK HUBER ∞MARY LYNNEAND HOWELLS CLAUDIA ANDJERRY CATHY R.HOWARD & REPAIR,INC. HORIZON MANUFACTURING TAMIJI HOMMA LIZ HOLZEMER HODGSON SUSAN ANDTHOMAS FOUNDATION, INC. HK SYSTEMSEMPLOYEE HINCKLEY *JANICE AND*ROBERT ∞MR. THORNTONL.HILL CHEMICAL COMPANY HILL BROTHERS HIGGINS TED AND*KATHLEEN ANN HIGGINS RICK ANDJULIE EDWARD HIGBEE M. JUNEAND PEGGY HICKS JUNE ANDCLAUDEHICKEN ∞HEVERT INDUSTRIES,INC. C. CHARLESHETZEL SUPPLY COMPANY HERRICK INDUSTRIAL NITE, CO. HERAEUS ELECTRO- JOHN HENKELS ∞MR. ANDMRS. AND ALYCEZ.HEIDT EDWARD A.HEIDTJR. FOUNDATION HECTOR C.HAIGHT EILEEN HEALY ∞L. RUSSELLAND HD SMITHFOUNDATION HAYDEN NANCY ANDROBERT BARBARA HATCH *DAVID AND SHARON HARVEY FOUNDATION, INC. HARRY W.MORRISON KATSANEVAS NICKIE ANDCHRIS TOM KARTSOTIS FOUNDATION KARL M.JOHNSON ∞BARBARA F.KAMPEN CONTRACTORS, INC. K OHMECHANICAL CALLIE JONES STATE UNIVERSITY OF BUSINESSATUTAH JON M.HUNTSMANSCHOOL FRANK JOKLIK PAMELA ANDG. RUTH E.JOHNSON JACK B.JOHNSON WESLEY A.JOHNSONFAMILY ∞THE CAROLM.AND JOHNSON POWER,LTD. 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*DECEASED ENDOWMENT TRUST UNITED JEWISH COMMUNITY AND FAMILY ∞*MARY LOUUNICE MANUFACTURING COMPANY UINTAH MACHINEAND TWARD, MD HEIDI ANDJONATHAN *MARJORIE TURNER & TOOL,INC. TURN-TEX MACHINE BARB ANDBENTUCKER TUBE CITYIMS TRUCK SHIELDS,LLC FUND, INC. TOYS “R”USCHILDREN’S JOHN ROSSWOG ROSSWOG AND ELIZABETH THOMAS- HAUER TRUST TJ ANDGOLDIE EDWARD THATCHER MARSHA ANDJ. TEVA PHARMACEUTICALS ALLAN TESSLER FRANCES AND TEAMIRONDEAN 5K EDWIN TAZOI HIGH SCHOOL TAYLORSVILLE JAMES TAYLOR ∞TERRY AND PAM ANDBENJAMINTANNER FOUNDATION THE T.R.PAULFAMILY SYMANTEC GIVINGSTATION HEALTH ANDWELLNESS SWEET CANDYFUNDFOR LEWIS SWAIN PATRICE ANDH. WIRTHLIN FOUNDATION THE SUSANILEENE THE SUPPORTGROUP,LLC SUPER 1FOODS SUNDOWNER STATION,INC. SUNBEAM FOUNDATION M. 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MARIO WINTER DAVID WINDER JERALYNN AND LINDA ANDJAMESWILSON GOODRICH &ROSATI WILSON SONSINI ∞KENNETH L.WILLIAMS WILLIAMS DEBBIE AND*ANDY ANN M.WILLIAMS WILLA’S WORKSHOP BARBARA WILDING TIMOTHY AND ELECTRIC WHITEHEAD WHOLESALE DARLENE ANDJONWHITE LIVING TRUST THE WHITEREVOCABLE LINDA WHITAKER MARLENE WHICKER WHEELWRIGHT ∞STEVEN ANDMARGARET COMPANY WHEELER MACHINERY RECYCLING, LLC WESTERN METALS ENGINEERING, INC. WESTECH ∞KAREN ANDSTEVENWEST HIGH SCHOOL WEST JORDAN Donors 75 76 APPENDIX Published Research Gren L,BoffettaP, ZhangZF,LaVecchiaC Hashibe M(CCPS), GaleoneC,BuysSS(CCPS), BR JCANCER:113:809-16 (2015)PMCID:PMC4559834 PLCO Cohort Coffee, Tea,CaffeineIntake,and theRiskofCancerin Tillmanns T,ValeaFA,YasharCM, McMillianNR,ScavoneJL Mutch D,FaderAN,RemmengaSW, ReynoldsRK,TengN, CM, FrederickP,GaffneyDK(ET), HanE,HuhWK,LurainJR, KR, ChuC,CohnD,CrispensMA, Dorigo O,EifelPJ,Fisher Koh WJ,GreerBE,Abu-RustumNR,ApteSM,CamposCho J NATLCOMPRCANCNETW:13:395-404;QUIZ404(2015) Cervical Cancer,Version2.2015 CP, KushiLH,SweeneyC(CCPS),CaanBJ EP, MaxfieldKS,StijlemanIJ,LangholzBM,Quesenberry (CRR), HabelLA,WeltzienEK,CastilloA,Gunderson Kwan ML,BernardPS(ET),KroenkeCH,FactorRE J NATLCANCERINST:107:DJV087(2015)PMCID:PMC4554253 Prognosis andSurvival Breastfeeding, PAM50TumorSubtype,andBreastCancer GS, ZankeBW,GaudermanWJ,PetersU,HsuL,ChanAT ML (CCPS),ThibodeauSN,ThomasF,ThornquistM,Warnick SA, RudolphA,SchoenRE,SchumacherFR,SeminaraD,Slattery L, NewcombPA,OginoS,PflugeisenBM,PotterJD,QuC,Rosse Hudson TJ,JenkinsMA,JiaoS,LindorNM,LemireM,LeMarchand J, HaileRW,HarrisonTA,HayesRB,HoffmeisterM,HopperJL, M, DugganD,FigueiredoJC,FuchsCS,GiovannucciEL,Gong Carlson CS,CaseyG,Chang-ClaudeJ,ChanockSJ,Cotterchio JA, BerndtSI,BrennerH,ButterbachK,CaanBJ,CampbellPT, Nan H,HutterCM,LinY,JacobsEJ,UlrichWhiteE,Baron JAMA:313:1133-42 (2015)PMCID:PMC4382867 Cancer AccordingtoGeneticVariants Association ofAspirinandNSAIDUsewithRiskColorectal B, StraifK,HashibeM(CCPS) Huang YH,ZhangZF,TashkinDP,Feng 31 (2015)PMCID:PMC4302404 CANCER EPIDEMIOLBIOMARKERSPREV:24:15- An EpidemiologicReviewofMarijuanaandCancer:Update MW (CRR),McMahonMHolmenSL(CRR) DA, ChenG,DaviesMA,GrossmannAH,VanBrocklin Cho JH,RobinsonJP,AraveRA,BurnettWJ,Kircher CELL REP:13:898-905(2015)PMCID:PMC4681594 Melanoma Metastases AKT1 ActivationPromotesDevelopmentof Reblin M,ClaytonMF(CCPS),JohnKK,EllingtonL(CCPS) HEALTH COMMUN:1-9(2015) Longitudinal InteractionsinHomeHospiceCancerCare Communication DataSets:CollectingandCoding Addressing MethodologicalChallengesinLarge Chu TW,ZhangR,YangJ,ChaoMP,ShamiPJ(ET),KopechekJ(ET) THERANOSTICS:5:834-46 (2015)PMCID:PMC4440441 May AchieveSuperiorAnti-LymphomaEfficacytoRituximab A Two-StepPretargetedNanotherapyforCD20Crosslinking Miller GD,O’HareT(CRR),DeiningerMW(ET),LimCS(CRR) Woessner DW,EiringAM,BrunoBJ,ZabriskieMS,ReynoldsKR, LEUKEMIA:29:1668-75 (2015)PMCID:PMC4621806 Native andKinase-MutantChronicMyeloidLeukemia A Coiled-CoilMimeticInterceptsBCRABL1Dimerizationin

YH (ET),Jan·t-Amsbury M(ET) Cho S,ParkH,Jarboe EA,PetersonCM,Bae PLOS ONE:10:E0141172 (2015)PMCID:PMC4619203 Stem Cells Design andCharacterizationof Bioengineered Cancer-Like PS (ET),EllisMJ,PerouCM,DiLeo A,CareyLA Pritchard KI,LevineMN,Bramwell VH, ParkerJ,Bernard Borrego M,CalvoL,AlbaE,Carrasco E,CaballeroR,TuD, Rodriguez-Lescure A,RuizChiaS,ShepherdL,Ruiz- Cheang MC,MartinM,NielsenTO,PratA,VoducD, ONCOLOGIST:20:474-82 (2015)PMCID:PMC4425383 Receptor Expression Defining BreastCancerIntrinsicSubtypesbyQuantitative SJ (ET),GolubovskayaVM,RosenblattJ(CRR) Gu Y,SheaJ,SlattumG,FirpoMA,AlexanderM,Mulvihill ELIFE:4:E04069 (2015)PMCID:PMC4337653 Tumor Hallmarks Defective ApicalExtrusionSignalingContributestoAggressive TA, CaseyG,GruberSB,HunterDJ,AmosCI,HendersonB H, PhelanC,WentzensenN,PetersU,SlatteryML(CCPS),Sellers H, ChanockS,BerndtSI,KraftP,LindstrˆmAlOlamaAA,Song Field JK,BickebˆllerH,RischA,Kote-JaraiZ,WiklundF,Grˆnberg F, EastonDF,LandiMT,BrennanP,HoulstonR,ChristianiDC, Poirier JG,RiderDN,FridleyBL,ChenZ,HaimanC,Schumacher Marchand LL,SchildkrautJ,WitteJS,EelesR,BoffettaP,SpitzMR, Hung RJ,UlrichCM(CCPS),GoodeEL,BrhaneY,MuirK,ChanAT, J NATLCANCERINST:107:DJV246(2015)PMCID:PMC4675100 Colorectal Cancer for FiveCommonCancers:Lung,Ovary,Prostate,Breast,and Cross CancerGenomicInvestigationofInflammationPathway Chakraborty R,LiY,ZhouL,GolicKG(NC) PLOS GENET:11:E1005400(2015)PMCID:PMC4521751 Feedback Loop Corp RegulatesP53inDrosophilamelanogasterviaaNegative Baron R,O’HareT(CRR),GunningPT,DeiningerMW(ET) WL, TantravahiSK,TodicA,ColaguoriR,MorigglWilsonDJ, Anderson DJ,SeninaA,PomicterAD,ArpinCC,AhmadS,Heaton Zabriskie MS,ZhangTY,KhorashadJS,EngarAJ,ReynoldsKR, Eiring AM,PageBD,KraftIL,MasonCC,VelloreNA,ResetcaD, LEUKEMIA:29:586-97 (2015)PMCID:PMC4334758 Lethality inTherapy-ResistantChronicMyeloidLeukemia Combined STAT3andBCRABL1InhibitionInducesSynthetic Bastholt L,YangA,RollinLM,HorakC,HodiFS,WolchokJD Callahan MK,PostowMA,GrossmannK(ET),SznolM,DrenoB, M, Marquez-RodasI,McArthurGA,AsciertoPA,LongGV, Ferrucci PF,HillA,WagstaffJ,CarlinoMS,HaanenJB,Maio Lao CD,SchadendorfD,DummerR,SmylieM,RutkowskiP, Larkin J,Chiarion-SileniV,GonzalezR,GrobJJ,CoweyCL, N ENGLJMED:373:23-34(2015) Untreated Melanoma Combined NivolumabandIpilimumaborMonotherapyin Whittemore AS,ChungWK,ApicellaC,HopperJL IL, BuysSS(CCPS),GoldgarDEKnightJA, Terry MB,PhillipsKA,DalyJohnEM,Andrulis INT JEPIDEMIOL:(2015) Cohort (ProF-SC) Cohort Profile:TheBreastCancerProspectiveFamilyStudy from January1,2015toDecember31, A sampleofmorethan460publicationsbyHCIinvestigators BR (NC),Chandrasekharan MB(NC),BhaskaraS(NC) JR, JonesS,McDowell ME,WellmanH,TylerJK,Cairns Johnson DP,Spitz GS,TharkarS,QuayleSN,Shearstone ONCOTARGET:6:4863-87 (2015)PMCID: PMC4467121 Mutant DiffuseLargeB-CellLymphoma Repair toOvercomeChemoresistance inEZH2Gain-of-Function HDAC1,2 InhibitionImpairsEZH2- andBBAP-MediatedDNA W_tek M,WolfJ,SlagerS,CampNJ (CCPS),CanzianF,VachonC H, MartinT,Martinez-LopezJ,Rajkumar V,SainzJ,VangstedAJ, M, Cannon-AlbrightLA(CCPS),JonesB,LeeAMarques Jamroziak K,JurczyszynA,KumarS,AtanackovicD(ET),Glenn Dumontet C,Dudzi_skiM,FejermanL,GreenbergA,HuntsmanS, D, AftabB,BracciP,BudaG,ZhaoY,Caswell-JinJ,DiasioR, Ziv E,DeanHuD,MartinoA,SerieCurtinK(CCPS),Campa NAT COMMUN:6:7539(2015) Associated withSurvivalinMultipleMyelomaPatients Genome-Wide AssociationStudyIdentifiesVariantsat16p13 G, RahmanN,RobsonM,DomchekSM,FoulkesWD Southey M,GoldgarDE(CCPS),EvansDG,Chenevix-Trench SV (CCPS),NathansonKL,DevileeP,MeindlA,CouchFJ, Easton DF,PharoahPD,AntoniouAC,TischkowitzM,Tavtigian N ENGLJMED:372:2243-57(2015)PMCID:PMC4610139 Cancer Risk Genepanel SequencingandthePredictionofBreast Caudill MA,ToriolaAT,GreenR,UlrichCM(CCPS) RL, DugganDJ,HabermannN,BaileyLB,ManevalDR, Brown EC,BeresfordSA,ZhengY,PooleEM,Galbraith Cheng TY,MakarKW,NeuhouserML,MillerJW,SongX, CANCER:121:3684-91 (2015)PMCID:PMC4592375 Women’s HealthInitiativeObservationalStudy Interactions withNutritionalFactorsonColorectalCancerRisk: Folate-Mediated One-CarbonMetabolismGenesand (CCPS), Cannon-AlbrightLA(CCPS) Neklason DW(CCPS),VanDersliceJ,CurtinK ENDOCR RELATCANCER:23:93-100(2015)PMCID:PMC4684974 Neuroendocrine TumorsoftheSmallIntestine Evidence foraHeritableContributionto Coghill AE,ShielsMS,SunejaG(CCPS),EngelsEA0 J CLINONCOL:33:2376-83(2015)PMCID:PMC4500831 in theUnitedStates Elevated Cancer-SpecificMortalityAmongHIV-InfectedPatients Sinha NK,TrettinKD,AruscavagePJ,BassBL(NC) MOL CELL:58:406-17(2015)PMCID:PMC4433149 Loquacious-PD dsRNA Termini-DependentStatesthatAreModulatedby Drosophila Dicer-2CleavageIsMediatedbyHelicase-and Stump T,KohlmannWG,LeachmanSA(CCPS) Wu YP(CCPS),AspinwallLGMichaelisTC, J COMMUNITYGENET:7:21-31(2015)PMCID:PMC4715817 Genetic Testing Behaviors withChildrenandGrandchildrenafterMelanoma Discussion ofPhotoprotection,Screening,andRisk JP, ScaifeCL(ET),AtorMA,RuggeriBA,DorseyBD,KuwadaSK Shen Y,ZificsakCA,SheaJE,LaoX,BolltO,LiLiskoJG,Theroff J MEDCHEM:58:1140-58(2015) and Spread Acrylonitriles asNovelInhibitorsofCancerMetastasis Design, Synthesis,andBiologicalEvaluationofSulfonyl

Riedl J,DingY,FlemingAM,BurrowsCJ(NC) NAT COMMUN:6:8807(2015)PMCID:PMC4667634 Amplification andNanoporeSequencing Identification ofDNALesionsUsingaThirdBasePairfor Kepka D(CCPS), DingQ,BodsonJ,WarnerEL,Mooney K(CCPS) J CANCEREDUC:30:808-12 (2015) Sons andDaughters inaStatewithLowThree-Dose Completion Latino Parents’Awarenessand Receipt oftheHPVVaccinefor Colman H(ET),JensenRL(ET/NC), HuangLE(NC) Choi H,GillespieDL,BergS,Rice C, CouldwellS,GuJ, PLOS ONE:10:E0125125(2015)PMCID: PMC4404255 Malignant ProgressionIndependent ofItsContinuedExpression Intermittent InductionofHIF-1Produces LastingEffectson Price R,PoursaidA,CappelloJ,GhandehariH(ET) J CONTROLRELEASE:213:96-102(2015)PMCID:PMC4684501 Elastinlike ProteinPolymersforCancerGeneTherapy In vivoEvaluationofMatrixMetalloproteinaseResponsiveSilk- Couch FJ,GaytherS,PharoahPP,AntoniouAC,Chenevix-TrenchG Kupryjanczyk J,FreedmanM,NoushmehrH,EastonDF,OffitK, G, PikeMC,Dansonka-MieszkowskaA,TimorekRzepeckaIK, Menon U,HarringtonP,LeeA(CCPS)W,WuAH,PearceCL,Coetzee TA, TsaiYY,ChenZ,ZiogasA,Anton-CulverH,Gentry-MaharajA, Narod SA,MonteiroAN,ChenA,LinHY,Permuth-WeyJ,Sellers BT, ZhengW,ShuXO,GaoYT,RosenB,RischHA,McLaughlinJR, Glasspool R,WhittemoreAS,RothsteinJH,McGuireV,SiehW,Ji Baker H,SongEcclesD,McNeishI,PaulJ,CartyK,SiddiquiN, J, BrintonLA,WentzensenN,HogdallC,LundvallL,Nedergaard A, KelemenLE,CookLS,LeND,CybulskiC,YangH,Lissowska AM, AbenKK,KiemeneyLA,MassugerLF,KellarM,Brooks-Wilson Olson SH,KrakstadC,SalvesenHB,TangenIL,BjorgeL,vanAltena Cramer DW,TerryKL,PooleEM,TworogerSS,BanderaEV,OrlowI, Berchuck A,IversenES,SchildkrautJM,ConcannonP,WeberRP, Giles GG,LiangD,HildebrandtMA,WuX,LevineDA,BisognaM, Fridley BL,GoodeEL,CunninghamJM,VierkantRA,BruinsmaF, A, KjaerSK,HogdallE,HasmadHN,AzmiMA,TeoSH,WooYL, Heitz F,SchwaabI,HarterP,MatsuoK,HosonoS,OrsulicJensen Butzow R,ModugnoF,KelleyJL,EdwardsRP,NessRB,duBoisA, P, DˆrkT,AntonenkovaN,BogdanovaLeminenA,PelttariLM, MT, ThompsonPJ,ShvetsovYB,RunnebaumIB,D¸rstM,Hillemanns Moysich KB,OdunsiK,SuchestonL,LeleS,WilkensLR,Goodman Rossing MA,RudolphA,Chang-ClaudeJ,Wang-GohrkeS,EilberU, E, VergoteI,LambrechtsS,DicksDohertyJA,WicklundKG, Beckmann MW,FaschingPA,LambrechtsD,VanNieuwenhuysen Domchek SM,LuKH,KarlanBY,WalshC,LesterJ,HeinA,EkiciAB, Askmalm M,OlopadeOI,NussbaumRL,RebbeckTR,NathansonKL, E, LaitmanY,SollerM,LiljegrenA,ArverB,EinbeigiZ,Stenmark- Jensen UB,KruseTA,ThomassenM,BojesenA,ZidanJ,Friedman G, MulliganAM,TchatchouS,AndrulisIL,GlendonTolandAE, A, SingerCF,TeaMK,PhelanCM,GreeneMH,MaiPL,Rennert Lindor N,SzaboCI,KauffVijaiJ,AghajanianCA,PfeilerG,Berger Montagna M,TognazzoS,TeixeiraMR,PankratzVS,WangX, J, SukiennickiG,BarkardottirRB,PlanteM,SimardSoucyP, Brunet J,LazaroC,PujanaMA,JakubowskaA,GronwaldLubinski Caligo MA,CampbellIG,HogervorstFB,OlahE,DiezO,BlancoI, L, TungN,HamannU,IsaccsC,TischkowitzM,ImyanitovEN, Nevanlinna H,CollÈeJM,RookusMA,OosterwijkJC,Tihomirova Piedmonte M,O’MalleyDM,delaHoyaCaldesT,Aittom‰kiK, S, Stoppa-LyonnetD,ClaesK,DeLeeneerKirkJ,RodriguezGC, RK, MeindlA,EngelC,SutterSinilnikovaOM,DamiolaF,Mazoyer Garber J,FrostD,PerkinsPlatteR,EllisS,GodwinAK,Schmutzler Manoukian S,RadiceP,PapiL,OttiniFostiraF,KonstantopoulouI, Ganschow P,PeterlongoBernardL,VielA,BonanniB,Peissel Dennis J,BenitezOsorioA,GarciaMJ,KomenakaI,WeitzelJN, YC, HansenTV,J¯nsonL,GerdesAM,EjlertsenB,BarrowdaleD, Janavicius R,DorflingCM,vanRensburgEJ,NeuhausenSL,Ding A, SoutheyM,TerryMB,GoldgarDE(CCPS),BuysSS TJ, LinYG,PejovicT,BeanY,LiQ,CoetzeeS,HazelettD,Miron Beesley J,LawrensonK,McGuffogL,HealeyS,LeeJM,Spindler Kuchenbaecker KB,RamusSJ,TyrerJ,LeeA(CCPS),ShenHC, NAT GENET:47:164-71(2015)PMCID:PMC4445140 Epithelial OvarianCancer Identification ofSixNewSusceptibilityLociforInvasive

Published Research 77 APPENDIX 78 APPENDIX Published Research Garrido-Laguna I (ET), HidalgoM NAT REVCLINONCOL:12:319-34 (2015) Promising Novel Therapies Pancreatic Cancer:FromState-of-the-Art Treatmentsto J, WestBL,NolopKB,HsuHH,Ligon KL,MolinaroAM,PradosM PY, CloughesyTF,MarimuthuA,Haidar S,PerryA,HuseJ,Phillips Butowski N,ColmanH(ET),DeGroot JF,OmuroAM,NayakL,Wen NEURO ONCOL:18:557-64(2015) Early PhaseClinicalTrialsConsortiumIIStudy Inhibitor PLX3397inRecurrentGlioblastoma:AnIvyFoundation Orally AdministeredColonyStimulatingFactor1Receptor Yosef N,ChanRC,RegevA,WilliamsMA(CRR),TantinD(NC) Shakya A,GorenShalekGermanCN,SnookJ,KuchrooVK, J EXPMED:212:2115-31(2015)PMCID:PMC4647264 T-Cell Function Oct1 andOCA-BAreSelectivelyRequiredforCD4Memory TA, SwansonSJ,TauerK,YangSC,GregoryHughesM Pisters KM,ReckampK,RielyGJ,RohrenE,SchildSE,Shapiro Lilenbaum R,LinJ,LooBW,MartinsOttersonGA,PatelJD, Horn L,JahanTM,KomakiR,KrugLM,LacknerRP,LanutiM, TL, DillingTJ,DobelbowerMC,GovindanR,GrannisFW, H, CamidgeDR,CheneyRT,ChirieacLR,D’AmicoTA,Demmy Ettinger DS,WoodDE,AkerleyW(ET),BazhenovaLA,Borghaei J NATLCOMPRCANCNETW:13:515-24(2015) Non-Small CellLungCancer,Version6.2015 Contreras JL(CCPS) TRENDS GENET:31:55-7(2015) NIH’s GenomicDataSharingPolicy:TimingandTradeoffs Schwartzberg LS,VenookAP,GockeCD,TaitJ,StewartFM CL, CarsonWE,ClarkJW,DiPersioJF,EttingerDS,MorganRJ, Kurzrock R,ColevasAD,OlszanskiA,AkerleyW(ET),Arteaga J NATLCOMPRCANCNETW:13:1337-46(2015) Profiling Surveys Committee andNCCNBestPracticesMolecular NCCN OncologyResearchProgram’sInvestigatorSteering Ebert BL,RodigSJ,TynerJW,MartoJA,WeinstockDM,LaneAA Makishima H,TurleySJ,Javidi-SharifiN,MaciejewskiJP,JaiswalS, AL, ElpekKG,CardJ,GritsmanK,GotlibDeiningerMW(ET), Y, WeigertO,KoppN,WuSC,KimSS,LiuH,TiveyT,Christie Yoda A,AdelmantG,TamburiniJ,ChapuyB,ShindohN, NAT MED:21:71-5(2015)PMCID:PMC4289115 and KinaseInhibitorResistance Mutations inGProteinβSubunitsPromoteTransformation Cohen AL(ET),Welm(CRR),AyerDE(NC) Shen L,O’SheaJM,KaadigeMR,CunhaS,WildeBR, (2015) PMCID:PMC4418882 PROC NATLACADSCIU.S.A:112:5425-30 through MycSuppressionofTXNIP Metabolic ReprogramminginTriple-NegativeBreastCancer Spigarelli MG,MooneyK(CCPS) Kepka D(CCPS),WarnerEL,KinneyAY, J IMMIGRMINORHEALTH:17:125-31(2015) Latino ParentsinUtah Low HumanPapillomavirus(HPV)VaccineKnowledgeamong

Botkin JR,RothwellE(CCPS),AndersonR,StarkLA,MitchellJ J COMMUNITYGENET:6:183(2015)PMCID:PMC4356674 Information andResidualClinicalTissuesforResearch Public AttitudesRegardingtheUseofElectronicHealth Lowrance WT(CCPS),FarnhamJM,AlbrightLA(CCPS) Albright F,StephensonRA,AgarwalN(ET),TeerlinkCC, PROSTATE:75:390-8 (2015)PMCID:PMC4293302 Cancer FamilyHistory Prostate CancerRiskPredictionBasedonComplete R, SeoJ,DresslerLG,GoodfellowPJ,GoodmanMS Kaphingst KA(CCPS),IvanovichJ,BieseckerBB,Dresser CLIN GENET:89:378-84(2015) Young Age Sequencing amongWomenDiagnosedwithBreastCancerata Preferences forReturnofIncidentalFindingsfromGenome Bieniasz M,RadhakrishnanP,FahamN,DeLaOJP,WelmAL(CRR CLIN CANCERRES:21:5588-600(2015)PMCID:PMC4681594 Expressing BreastCancerPatient-DerivedXenografts Combination withPI3KInhibitorsforTreatmentofsfRon- Preclinical EfficacyofRonKinaseInhibitorsAloneandin S (NC),JensenST,MaleyCC,SchiffmanJD(NC) Campbell MS,KisoWK,SchmittDL,WaddellPJ,Bhaskara Abegglen LM,CaulinAF,ChanA,LeeK,RobinsonR, JAMA:314:1850-60 (2015) Comparative CellularResponsetoDNADamageinHumans Potential MechanismsforCancerResistanceinElephantsand Choi JW,LeeYS,YunCO,KimSW(ET) J CONTROLRELEASE:219:181-91(2015)PMCID:PMC4668934 Polymeric OncolyticAdenovirusforCancerGeneTherapy Wang Q,vonRoemelingR,ShusterD,SchwartzB D, HirshV,ShepherdFA,SequistLV,SandlerA,RossJS, A, BarlesiF,AkerleyW(ET),OrlovS,SantoroSpigel Scagliotti G,vonPawelJ,NovelloS,RamlauR,Favaretto J CLINONCOL:33:2667-74(2015) Cell LungCancer Locally AdvancedorMetastaticNonsquamousNon-Small- versus ErlotinibAloneinPreviouslyTreatedPatientsWith Controlled StudyofTivantinib(ARQ197)plusErlotinib Phase IIIMultinational,Randomized,Double-Blind,Placebo- JF, KimSY,TimmermanJM,ShippMA,ArmandP Freeman GJ,RodigSJ,ChapuyB,LigonAH,ZhuL,Grosso EC, GutierrezM,SchusterSJ,MillensonMM,CattryD, Ansell SM,LesokhinAM,BorrelloI,HalwaniA(ET),Scott N ENGLJMED:372:311-9(2015)PMCID:PMC4348009 Hodgkin’s Lymphoma PD-1 BlockadewithNivolumabinRelapsedorRefractory Hanson HA(CCPS), SmithKR(CCPS),ZimmerZ DEMOGRAPHY:52:2021-49 (2015)PMCID:PMC4655204 Utah Population Database Trajectories: AMedicare-Linked CohortStudyFromthe Reproductive HistoryandLater-Life Comorbidity O’Hare T(CRR) Zabriskie MS,VelloreNA,GantzKC, DeiningerMW(ET), LEUKEMIA:29:1939-42 (2015)PMCID: PMC4536190 Domain-Mutant BCR-ABL1 Radotinib IsanEffectiveInhibitorofNativeandKinase from January1,2015toDecember31, A sampleofmorethan460publicationsbyHCIinvestigators

) PE, Christian HoekstraOS,DorfmanGS Sunderland JJ,Boellaard R,PerlmanES,Kinahan Graham MM,Wahl RL,HoffmanJM(ET),YapJT J NUCLMED:56:955-61 (2015)PMCID:PMC4587663 in OncologyClinicalTrials Summary oftheUPICTProtocol for18F-FDGPET/CTImaging C, SundquistWI(CRR),HansonPI, FrostA(CRR) Saunders MG,NaismithTV,ColfLA, AfonineP,Arthur McCullough J,ClippingerAK,Talledge N,SkowyraML, SCIENCE:350:1548-51 (2015)PMCID:PMC4684769 Helical Polymers Structure andMembraneRemodelingActivityofESCRT-III Drilon A,DeiningerMW(ET),O’HareT(CRR),DrukerBJ Davare MA,VelloreNA,WagnerJP,EideCA,GoodmanJR, (2015) PMCID:PMC4593101 PROC NATLACADSCIU.S.A:112:E5381-90 ROS1 TyrosineKinaseInhibitors Structural InsightintoSelectivityandResistanceProfilesof FG, RobinsonH,CohenRE,YaoT,HillCP(NC) VanderLinden RT,HemmisCW,SchmittB,NdojaA,Whitby MOL CELL:57:901-11(2015)PMCID:PMC4355076 UCH37 Deubiquitylase Structural BasisfortheActivationandInhibitionof Reblin M,ClaytonMF(CCPS),JohnKK,EllingtonL(CCPS) PALLIAT SUPPORTCARE:13:465-72(2015) Nurses andFormerFamilyCaregivers Social SupportNeeds:DiscordancebetweenHomeHospice A, BonneauK,UllmanKS(CRR),O’HareTDeiningerMW(ET) MS, HeatonWL,TantravahiSK,KauffmanM,ShachamS,Chenchik HM, YuF,KraftIL,PomicterAD,ReynoldsKR,IovinoAJ,Zabriskie Khorashad JS,EiringAM,MasonCC,GantzKC,BowlerAD,Redwine BLOOD:125:1772-81 (2015)PMCID:PMC4357584 Independent Resistance Transport asaMediatorofBCR-ABL1Kinase- shRNA LibraryScreeningIdentifiesNucleocytoplasmic Provenzale D,KinneyAY,UlrichC(CCPS),BurtRW(CCPS) (CCPS), MineauGPSmithKFraserA,WanY, Samadder NJ(CCPS),CurtinKPappasL,Boucher CLIN GASTROENTEROLHEPATOL:14:279-286.E2(2015) Colonoscopy: APopulation-BasedStudyinUtah Risk ofIncidentColorectalCancerandDeathAfter Lophatonanon A,RincklebAE,Kote-JaraiZ,EelesRA,EastonDF Govindasami K,SawyerE,WilkinsonR,HerkommerHopperJL, D, SaundersE,TymrakiewiczM,GuyDadaevT,LittleSJ, Cox A,SoutheyMC,SpurdleAB,FitzGeraldL,Leongamornlert RP, FoulkesWD,ZeegersMP,LuYJ,ZhangHW,StephensonR, T, ThibodeauSN,CooneyKA,ChappuisPO,HutterP,Kaneva L (CCPS),BrennerH,RebbeckTR,Zeigler-JohnsonC,Habuchi JY, CybulskiC,MaierDoerkT,DickinsonJL,Cannon-Albright M, NordestgaardBG,InglesSA,SorensenKD,OrntoftTF,Park EA, StanfordJL,BatraJ,ClementsJA,ChambersSK,Weischer Haiman CA,SchumacherFR,PashayanN,PharoahPD,Ostrander DE, HamdyFC,DonovanJL,MuirK,SchleutkerJ,HendersonBE, Amin AlOlamaA,BenllochS,AntoniouAC,GilesGG,SeveriG,Neal 9 (2015)PMCID:PMC4491026 CANCER EPIDEMIOLBIOMARKERSPREV:24:1121- Cancer SusceptibilityLoci Multinational Consortium,Using25KnownProstate Risk AnalysisofProstateCancerinPRACTICAL,a

AH, CapecchiMR (NC),JonesKB(NC)(2015) MJ, Smith-FryK, Cable MG,WangY,Grossmann Barrott JJ,IllumBE, JinH,ZhuJF,MosbrugerT,Monument ONCOTARGET:6:22758-66 (2015) PMCID:PMC4673197 Epithelial Transition Synovial SarcomagenesisandBlocks theMesenchymalto β-catenin StabilizationEnhances SS18-SSX2-Driven Valea FA,YasharCM,McMillianNR, ScavoneJL D, FaderAN,RemmengaSW,ReynoldsRK,TillmannsT, S, HanE,HigginsHuhWK,LurainJR,MarianiA,Mutch Eifel PJ,FisherCM,FrederickP,GaffneyDK(ET),George Cho KR,ChuC,CohnD,CrispensMA,DizonDS,DorigoO, Koh WJ,GreerBE,Abu-RustumNR,ApteSM,Campos J NATLCOMPRCANCNETW:13:1321-31(2015) NCCN Guidelines Uterine Sarcoma,Version1.2016:FeaturedUpdatestothe Moslehi JJ,DeiningerM(ET) J CLINONCOL:33:4210-8(2015)PMCID:PMC4658454 in ChronicMyeloidLeukemia Tyrosine KinaseInhibitor-AssociatedCardiovascularToxicity CJ, CarrellDT,GuccioneE,CairnsBR(NC) Hammoud SS,LowDH,YiC,LeeCL,OatleyJM,Payne GENES DEV:29:2312-24(2015)PMCID:PMC4647563 Postnatal MaleGermlineStemCells Transcription andImprintingDynamicsinDeveloping Parnell TJ,SchlichterA,WilsonBG,CairnsBR(NC) ELIFE:4:E06073 (2015)PMCID:PMC4423118 and Chromatin-BasedPromoterAntagonism The ChromatinRemodelersRSCandISW1DisplayFunctional Shin CH,GrossmannAH,HolmenSL(CRR),RobinsonJP GENES CANCER:6:9-18(2015)PMCID:PMC4362480 Gliomas InVivo The BRAFKinaseDomainPromotestheDevelopmentof CV, MacDonaldRJ,MurtaughLC(CRR) SG, ChenPanF,CashGM,BronnerMP(ET),Wright Krah NM,DeLaOJP,SwiftGH,HoangCQ,Willet ELIFE:4:E07125 (2015)PMCID:PMC4536747 of PancreaticDuctalAdenocarcinoma The AcinarDifferentiationDeterminantPTF1AInhibitsInitiation Ye Y,YaoB,LiA,DolemanS,VanderWaldeGansertJ,CoffinRS GP, DanielsGA,HarringtonK,MiddletonMR,MillerWH,ZagerJS, Milhem M,CranmerL,CurtiB,LewisK,RossGuthrieT,Linette N, ChesneyJ,DelmanKA,SpitlerLE,PuzanovI,AgarwalaSS, Andtbacka RH(ET),KaufmanHL,CollichioF,AmatrudaT,Senzer J CLINONCOL:33:2780-8(2015) Rate inPatientswithAdvancedMelanoma Talimogene LaherparepvecImprovesDurableResponse GT, RobisonLL,OeffingerKC,ParkER Leisenring W,DonelanK,WarnerEL,Armstrong Kirchhoff AC(CCPS),ParsonsHM,KuhlthauKA, J NATLCANCERINST:107:DJV057(2015)PMCID:PMC4650970 Cancer Survivors Disability InsuranceCoverageamongLong-TermChildhood Supplemental SecurityIncomeandSocial Published Research

79 APPENDIX 80 APPENDIX 200 18% >25 academic departments or colleges >25 academicdepartments supported byscientificfundingagencies supported at theUniversity of Utah 170 cancercenter members >$93 millioninvested inresearch NCI-MATCH inmajornationaltrialssuchas HCI participates open atanygiventime Cancer CareandOutreachHighlights ACROSS THE CANCER CENTER 450 LOCATIONS CLINICAL RESEARCH C C C C C f newtrialsopenedin2015 

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Educational eventsheldin impacted bycancer. Offerings include 436 125,000 1,200 4,000 245 83 15 18,000 patientvisits Health Center offers B. The LindaB.andRobert Wiggins Wellness andIntegrative 69 >500 73,000 14,000 group fitness, massage, mindfulnessgroups, The Wellness andIntegrative Health Center hosted nearly and manyothers. and four U.S. States: FREE SKIN CANCER SCREENINGS IN 2016: PATIENT CARE ANNUAL STATISTICS A DAY AT HCI WELLNESS AND SUPPORTIVE CARE ANNUAL STATISTICS EDUCATIONOUTREACH AND surgeries infusiontreatments screened for oral cancer radiology procedures screened for skincancer visitors to HCIatinaugural “Be Well Utah” OpenHouse geneticcounselingconsultations newcancersdiagnosed individuals served through visits, individualsserved calls, andemails peoplereached through community healthevents outpatientvisits

UT, WY, ID, NV 36 programs

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15 Utah counties

354 110 70 inpatients radiation therapy treatments outpatientvisits to support people people to support acupuncture, acupuncture,