HUNTSMAN CANCER INSTITUTE CANCER HUNTSMAN Report to Our Community to Our Report 2017 R E P O R T T O O U R C O M M U N I T Y I H U N T S M A N C A N C E R I N S T I T U T E I U N I V E R S I T Y O F U T A H THE PRIMARY CHILDREN’S & FAMILIES’ CANCER RESEARCH CENTER AT HUNTSMAN CANCER INSTITUTE OPENING SUMMER 2017, this 220,000 square-foot expansion will double HCI’s research capacity. Connected to the existing research facility via two skybridges, the new space is designed for the following: • Study the leading causes of disease death in children: leukemia, sarcoma, and brain cancer. • Advance our understanding of cancers that run in families. • Accelerate the discovery of new treatments for all cancers. • Improve long-term quality of life for cancer survivors. U.S. NEWS & WORLD REPORT BEST CANCER HOSPITALS • Provide world-class training opportunities for the next generation of cancer researchers. NATIONAL CANCER INSTITUTE- DESIGNATED COMPREHENSIVE CANCER CENTER NATIONAL COMPREHENSIVE CANCER NETWORK MEMBER AMERICAN COLLEGE OF SURGEONS COMMISSION ON CANCER ACCREDITED BECKER’S HOSPITAL REVIEW 100 GREAT ONCOLOGY PROGRAMS WHY NOW? The past has shown a 200% increase in cancer survivorship. By the year 2026, an estimated 20 VIZIENT QUALITY AND million people will be diagnosed with cancer in ACCOUNTABILITY STUDY the United States. #1 IN THE NATION FOR QUALITY Cancer moves fast. We have to move faster. OUR TIME BEGAN with an empty lot and a dream full of promise, determination, and audacity. A dream to do the impossible. Achieve the unachievable. Defeat the undefeatable. AS JON M. HUNTSMAN SAYS, Cancer moves fast. And we have to move faster.” CONTENTS 2 FOUNDERS LEAD EDITING AND DESIGN: Ashlee Bright 4 EVENTS Meredith Vehar Courtney Colvin Lisa Anderson CONTRIBUTORS: Linda Aagard 14 RESEARCH HIGHLIGHTS Jacqueline Brakey Charlie Ehlert Hannah Eisenberg Adam Finkle Diane Fouts Jonathan Martinez 26 PATIENT CARE Amie Parker Jill-Ann Pearl Susan Sheehan Jill Woods PRINTING: 34 EDUCATION AND OUTREACH Printer’s, Inc. Thank you to all who support our mission, including donors, volunteers, researchers, clinical care professionals, administrators, and Huntsman Cancer Foundation staff. 40 GIVING A special acknowledgment to our friends at the Moran Eye Center at the University of Utah for ideas that inspired APPENDICES the production of this report. HCI Director’s Cabinet 51 Internal Advisory Board 52 External Advisory Board 53 @huntsmancancerinstitute Cancer Center Program Leaders 54 Cancer Center Program Members 54 @huntsmancancerinstitute Multidisciplinary Disease Group Leaders 62 Disease Oriented Research Team Leaders 64 @huntsmancancer Donors 66 Published Research 76 www.huntsmancancer.org Clinical Care and Research Summary 80 Letter from Our Founders, Jon M. and Karen Huntsman EXTERNAL ADVISORY BOARD Edward Benz, MD When When I was I was a boy, a boy, people people said wesaid could we couldnever cure polio. PRESIDENT AND CEO EMERITUS “ Jonasnever E. cureSalk, polio.MD, proved Jonas they E. Salk,were wrong.MD, We know that DANA-FARBER CANCER INSTITUTE “ RICHARD AND SUSAN SMITH DISTINGUISHED devastatingproved they diseases were canwrong. be conquered. We know Itthat is our commit- PROFESSOR OF MEDICINE mentdevastating that cancer, diseases like polio, can is someday be conquered. only a haunting PROFESSOR OF PEDIATRICS, PROFESSOR OF GENETICS HARVARD MEDICAL SCHOOL memory.It is our commitment that cancer, like polio, Elizabeth Blackburn, PhD is someday only a haunting memory. NOBEL LAUREATE Jon M. Huntsman IRWIN M. JACOBS PRESIDENTIAL CHAIR ” PRESIDENT OF THE SALK INSTITUTE FOR Jon M. Huntsman BIOLOGICAL STUDIES Michael Caligiuri, MD HUNTSMAN CANCER INSTITUTE IS PART OF THE UNIVERSITY OF UTAH AND WHOLLY OWNED BY THE STATE OF UTAH DIRECTOR OF THE OHIO STATE UNIVERSITY COMPREHENSIVE CANCER CENTER CEO OF THE JAMES CANCER HOSPITAL AND SOLOVE RESEARCH CENTER WHEN WE FOUNDED Huntsman Cancer on childhood cancers and cancers that run in JL MARAKAS NATIONWIDE INSURANCE ENTERPRISE Institute (HCI) more than 20 years ago, we were families even more. We are joined in this effort FOUNDATION CHAIR IN CANCER RESEARCH one family hoping to ease the burden of cancer by major donations from the Church of Jesus THE OHIO STATE UNIVERSITY for others. To our joy and astonishment, we were Christ of Latter-day Saints, the State of Utah, Brian Druker, MD DIRECTOR OF KNIGHT CANCER CENTER soon joined by generous families, corporations, Intermountain Healthcare, and thousands of other ASSOCIATE DEAN FOR ONCOLOGY individuals, community groups, and foundations donors who are helping to make this $125 million, OHSU SCHOOL OF MEDICINE who shared our optimism and our belief that Utah 220,000-square-foot expansion financially possible. JELD-WEN CHAIR OF LEUKEMIA RESEARCH and the Mountain West deserved to have the best INVESTIGATOR AT HOWARD HUGHES MEDICAL INSTITUTE cancer care possible. Today our family’s investment, Since its founding, more than one million people OREGON HEALTH AND SCIENCE UNIVERSITY together with all the other gracious contributions, have donated to help make HCI what it is today. Rob DuWors, MPA DEPUTY DIRECTOR OF ADMINISTRATION AND PLANNING now exceeds $1.5 billion. Thank you to our dear Thanks to all of our generous supporters— JONSSON COMPREHENSIVE CANCER CENTER friends and supporters. Thank you! from the children who hold lemonade stands, UNIVERSITY OF CALIFORNIA AT LOS ANGELES to marathoners, to the individuals who can Elaine Fuchs, PhD GIVING It is extraordinary that HCI has accomplished so give $5, $10, or $25—we have accomplished REBECCA C. LANCEFIELD PROFESSOR OF much in so little time. Its first research laboratory MAMMALIAN CELL BIOLOGY AND DEVELOPMENT and outpatient clinics opened in 1999. From that something wondrous together. HCI’s expertise INVESTIGATOR AT HOWARD HUGHES MEDICAL INSTITUTE moment, HCI has stood as a beacon of hope on the now reaches into affiliate hospitals throughout THE ROCKEFELLER UNIVERSITY hillside of the University of Utah’s medical campus. the Mountain West, from Lake Tahoe, Nevada, Ernest T. Hawk, MD, MPH to Grand Junction, Colorado. Moreover, in the VICE PRESIDENT AND DIVISION CHIEF FOR CANCER In 2004, HCI added the region’s only cancer PREVENTION AND POPULATION SCIENCES global context, HCI has discovered more genes BOONE PICKENS DISTINGUISHED CHAIR EDUCATION AND OUTREACH AND EDUCATION specialty hospital. It features private patient for inherited cancers than any other center in the FOR EARLY PREVENTION OF CANCER THE UNIVERSITY OF TEXAS MD ANDERSON rooms, inspiring spaces that connote beauty and world. These discoveries cross a broad spectrum of hope while also offering the most state-of-the art CANCER CENTER cancers such as breast, ovarian, colon, melanoma, equipment and technologies available for cancer Timothy R. Rebbeck, PhD PATIENT CARE PATIENT paraganglioma, parathyroid, neurofibromatosis, PROFESSOR OF EPIDEMIOLOGY patients. From the outset, people from throughout and more. So whether you live in Utah or halfway HARVARD T.H. CHAN SCHOOL OF PUBLIC HEALTH the region and beyond have come for treatment at PROFESSOR OF MEDICAL ONCOLOGY HCI. The hospital census grew so quickly that an around the world, our research discoveries have DANA-FARBER CANCER INSTITUTE addition was built and opened in 2011 to double helped, benefitting all. Thomas Sellers, PhD, MPH CENTER DIRECTOR the patient care capacity. From the beginning, Karen and I have experienced many blessings in our DISTINGUISHED MOFFITT SCHOLAR RESEARCH HIGHLIGHTS RESEARCH researchers from all over the world have come to EXECUTIVE VICE PRESIDENT lifetime. We think Ralph Waldo Emerson said it contribute their expertise. MOFFITT CANCER CENTER AND RESEARCH INSTITUTE best when he wrote, “It is one of the most beautiful EVENTS Sandra M. Swain, MD As we write this letter, we are close to completing compensations of life that no man can sincerely JON WAS JUST 32 WHEN HIS MOTHER DIED OF CANCER. THE DISEASE TOOK HIS MEDICAL DIRECTOR AT WASHINGTON CANCER INSTITUTE try to help another without helping himself.” Our FATHER 21 YEARS LATER. PROFESSOR OF MEDICINE construction of the Primary Children’s and Families’ Cancer Research Center at HCI. humble and heartfelt thanks to all who have helped WHEN JON HIMSELF WAS DIAGNOSED WITH CANCER, HE DIDN’T JUST VOW TO BEAT ASSOCIATE DEAN FOR RESEARCH DEVELOPMENT FOUNDERS IT, “I VOWED TO ERADICATE IT FROM THE EARTH. AND I’M JUST CRAZY ENOUGH TO ADJUNCT PROFESSOR OF MEDICINE FOUNDERS This research expansion will allow us to focus alleviate the suffering caused by cancer. BELIEVE I CAN DO IT,” HE SAID. F. EDWARD HEBERT SCHOOL OF MEDICINE 2 GEORGETOWN UNIVERSITY MEDICAL CENTER 3 The White House Looks to Utah in the Cancer “Moonshot” Mission During the discussion, Governor Huntsman said he hoped everyone would walk away with an understanding of three things that he views as chiefly important to the progress of cancer research: the power of community collaboration, the power of the Utah Population Database, and the importance of rural and frontier cancer care. “You can go to Philadelphia, you can go to New York City, but it’s rare that you go to a cancer institute with this kind of rural outreach. We have Native Americans, veterans, and other minority groups who otherwise would not be able to access cancer treatment,” said Governor Huntsman. “What we do here is truly unique.” “We are thrilled and honored that Vice President Biden and the entire White House administration has recognized Huntsman Cancer Institute as one of the best in the nation and is looking to us as a valuable resource in this fight to cure cancer,” Beckerle said. “If we can work together and effectively leverage and harness ON FEBRUARY 26, 2016, Huntsman Cancer the information we are gathering, we can really Institute (HCI) had the honor of hosting GIVING accelerate progress.” Vice President Joe Biden as a part of President Obama’s cancer “moonshot” initiative.