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HIPK2 Recombinant Protein (OPCD03879) Data Sheet
Product Number OPCD03879
Product Page http://www.avivasysbio.com/hipk2-recombinant-protein-opcd03879.html
Product Name HIPK2 Recombinant Protein (OPCD03879)
Size 10 ug
Gene Symbol HIPK2
Alias Symbols DKFZp686K02111, FLJ23711, hHIPk2, Homeodomain-interacting protein kinase 2, PRO0593
Molecular Weight 27 kDa
Product Format Lyophilized
Tag N-terminal His Tag
Conjugation Unconjugated
NCBI Gene Id 28996
Host E.coli
Purity > 95%
Source Prokaryotic Expressed Recombinant
Official Gene Full Name homeodomain interacting protein kinase 2
Description of Target Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphoryla tes PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apopto sis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosp horylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co -suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator t hrough phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in respo nse to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. P hosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA da mage. Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of P DX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis.1
Reconstitution and Storage Reconstitute in PBS or others. Store at 2-8C for one month. Aliquot and store at -80C for 12 months. Avoid repeated freeze/thaw cycles.
Additional Information Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
Additional Information Residues: Ser977 - Ile1198
Lead Time Domestic: within 1-2 weeks delivery International: 1-3 weeks
Formulation Lyophilized in PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express HIPK2.
Swissprot Id Q9H2X6
Protein Name Homeodomain-interacting protein kinase 2
Protein Accession # NP_001106710.1
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express HIPK2.
Nucleotide Accession # NM_001113239.2
Species Reactivity Human
Application SDS-PAGE, WB, ELISA, IP
Image 1 SDS-PAGE
HIPK2 Recombinant Protein (OPCD03879) using SDS-PAGE
AVIVA SYSTEMS BIOLOGY manufactures and sells quality antibody products covering genome wide proteins.
This product is for Research Use Only. Not for diagnostic, human, or veterinary use. Optimal conditions of its use should be determined by end users.
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