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Excellent Long-Term Outcomes of the Arterial Switch Operation in Patients with Intramural Coronary Arteries

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Excellent Long-Term Outcomes of the Arterial Switch Operation in Patients with Intramural Coronary Arteries Excellent Long-Term Outcomes of the Arterial Switch Operation in Patients With Intramural Coronary Arteries Tyson A. Fricke, MBBS, BMedSci, Anne Eva Bulstra, BS, Phillip S. Naimo, MD, Andrew Bullock, MBBS, Terry Robertson, MBBS, Yves d’Udekem, MD, PhD, Christian P. Brizard, MD, and Igor E. Konstantinov, MD, PhD Royal Children’s Hospital, University of Melbourne, Murdoch Children’s Research Institute, Melbourne, Australia; Princess Margaret CONGENITAL HEART Hospital for Children, Perth, Australia; and The Women’s and Children’s Hospital, Adelaide, Australia Background. Intramural coronary arteries may compli- on the coronary arteries. Freedom from reoperation was cate coronary artery transfer during the arterial switch 93% at 10 years. No patient had more than mild aortic operation. We sought to determine the long-term outcomes regurgitation at last follow-up. Nine (32%, 9 of 28) pa- of 28 patients with intramural coronary arteries who un- tients had coronary angiograms at median 16 months derwent an arterial switch operation at a single institution. (range, 14 months to 17 years) after arterial switch oper- Methods. All patients who had intramural coronary ation. All patients were asymptomatic at the time of arteries and underwent an arterial switch operation were angiogram. One patient had mild stenosis of the identified from the hospital database and retrospectively circumflex coronary artery demonstrated on a routine reviewed. coronary angiogram 14 months postoperatively. All 28 Results. From 1983 to 2009, 720 patients underwent an patients were asymptomatic and in New York Heart As- arterial switch operation at our institution. Twenty-eight sociation functional class I at last follow-up. (3.9%, 28 of 720) had intramural coronary arteries. Conclusions. Patients with intramural coronary arteries Patients with intramural coronary arteries had trans- are not at increased risk of death or coronary reinter- position of the great arteries (96%, n [ 27) or Taussig- ventions and have excellent late outcomes after the arte- Bing anomaly (4%, n [ 1). There were no deaths. rial switch operation. Follow-up was 100% complete. Mean follow-up was 16.3 years (median, 15.5 years; range, 5.6 to 26.9 years). No (Ann Thorac Surg 2016;101:725–9) patient required reoperation or catheter reintervention Ó 2016 by The Society of Thoracic Surgeons he arterial switch operation (ASO) has excellent early Material and Methods Toutcomes with low mortality and morbidity rates in Patients the modern era [1–5]. Intramural coronary arteries ’ (IMCAs) may complicate coronary transfer and The study was approved by the Royal Children s Hospital contribute to a mortality of up to 28% in such patients (6). Human Research Ethics Committee. Between May 1983 A metaanalysis of 1,942 children demonstrated that an and January 2009, a total of 720 patients underwent an ’ IMCA was associated with a 6.5-fold increased risk of ASO at the Royal Children s Hospital. An ASO was per- ¼ mortality following ASO [7]. Recent studies on the out- formed for TGA (n 618), Taussig-Bing anomaly (TBA; ¼ ¼ comes of children with IMCAs who undergo the ASO n 57), congenitally corrected TGA (n 21), for atrial to ¼ demonstrated variable results [3, 6, 8] (Table 1). We have ASO conversion (n 15) and TGA with univentricular ¼ previously reported that the IMCA was not a risk factor physiology (n 9). All operation reports were reviewed fi for mortality in 618 children who underwent an ASO for and all patients with IMCA were identi ed. There were 28 transposition of the great arteries (TGA) over a 25-year (3.9%, 28 of 720) patients with IMCA. Twenty-seven (96%, period at our institution (2). Herein we describe the sur- 27 of 28) patients had TGA and 1 (4%, 1 of 28) patient had gical management of IMCA and the long-term outcomes TBA. Twenty (74%, 20 of 27) of the patients with TGA had for this subgroup of patients. an intact interventricular septum (TGA-IVS). fi Accepted for publication Aug 31, 2015. De nitions fi Presented at the Ninety-fifth Annual Meeting of the American Association An IMCA was de ned as any coronary pattern in which for Thoracic Surgery, Seattle, WA, April 24–29, 2015. at least one coronary artery coursed through the aortic ’ wall for a variable distance. Address correspondence to Dr Konstantinov, Royal Children s Hospital, fi Flemington Rd, Parkville, VIC 3052, Australia; email: igor.konstantinov@ Early death or reoperation was de ned as death or rch.org.au. reoperation occurring prior to hospital discharge or within Ó 2016 by The Society of Thoracic Surgeons 0003-4975/$36.00 Published by Elsevier http://dx.doi.org/10.1016/j.athoracsur.2015.08.090 726 FRICKE ET AL Ann Thorac Surg OUTCOMES OF ASO IN PATIENTS WITH INTRAMURAL CORONARY ARTERIES 2016;101:725–9 30 days of ASO. Late death or reoperation was defined as any death or reoperation that occurred after discharge and more than 30 days after ASO. Reoperation was defined as an operation on the heart or great vessels Follow-Up Mean, 2.9 y Mean, 1.6 y Mean, 8.3 y Median, 6.8 y Mean, 10 y performed after the ASO excluding exploration for bleeding, wound debridement, mechanical circulatory support and pacemaker replacement. Reintervention encompassed reoperation and catheter reintervention 0% 0% 14% 28% 5.6% performed after ASO. (1 of 7) (0 of 12) (1 of 18) (0 of 27) (13 of 46) Functional status was described according to the New York Heart Association (NYHA) classification. 0% 0% 0% 0% Statistical Analysis 5.7% (0 of 6) (0 of 12) (0 of 16) (0 of 27) (2 of 35) Data were analyzed using Stata Version 10 (Stata Corp, College Station, Texas). Continuous variables were re- ported as a mean or median with an accompanying range. Kaplan-Meier curves were constructed to display 0% 0% 14% freedom from the study’s outcomes. (1 of 7) (0 of 12) (1 of 18) (0 of 27) (11 of 46) CONGENITAL HEART Results Mortality Early Outcomes 4.4% 8.9% 3.7% (3 of 68) (14 of 158) (22 of 590) The intramural course involved the left main coronary artery in 24 (86%, 24 of 28) patients, the left anterior descending artery in 2 (7%, 2 of 28) patients, the right coronary artery in 1 (3.5%, 1 of 28) patient, and both left 0% NR NR 5.6% and right coronary arteries in 1 (3.5%, 1 of 28) patient 4.1% 1.0% (0 of 65) (4 of 98) (5 of 536) (Fig 1). Our approach to the IMCA (Fig 2A) was detach- Non-IMCA IMCA ment of the posterior commissure of the aortic (neo- pulmonary) valve in 25 (89%, 25 of 28; Fig 2B) patients and unroofing of the IMCA (Fig 2C) in 16 (57%, 16 of 28) pa- tients. Then the coronary arteries were detached and Early Late Overall Early Late Overall (3 of 68) (6 of 197) (10 of 158) (17 of 590) transferred either as a single button (Fig 2D) facilitated with a pericardial hood (Fig 2,D1–D3) in the first 3 (11%, 3 of 28) patients or as 2 separate buttons (Fig 2E) using the trapdoor technique (Fig 2,E1–E2) in the next 25 (89%, 25 of 28) patients. In all patients the pulmonary artery was reconstructed with a single autologous peri- cardial patch and the posterior neopulmonary commis- No. of IMCA sure was reattached to it. Patients, No. (%) Median age at operation was 9 days (mean, 15 days; range, 2 to 81 days) and median weight at operation was 3.5 kg (mean, 3.8 kg; range, 2.6 to 10 kg). Mean cardio- pulmonary bypass time was 158 min (median, 143 min; not reported. range, 93 to 275 min) and mean aortic cross clamp time ¼ Total No. of Patients was 89 min (median, 83 min; range, 49 to 149 min). Cir- culatory arrest was used in 50% of the patients with a mean circulatory arrest time of 9 min (median, 8 min; range, 5 to 54 min). 2012 75 7 (8.9) 4.4% 2006 2152005 168 18 (8.4) 12 (7.1) 3.0% 6.3% 2009 618 28 (4.5) 2.9% 2008 919 46 (5.0) NR NR 3.9% 24% – – – – – There were no early deaths or early reinterventions for the IMCA. There was no mechanical circulatory support 2008 1996 1999 1983 1987 in patients with IMCA before ASO. Two patients (7.4%, 2 of 28) with IMCA had TGA-IVS with poor preoperative left ventricular function and were supported with Med- [3] [6] [5] [2] tronic BioMedicus (Eden Prairie, Minnesota) centrifugal left ventricular assist device. The first patient was a 5-day- intramural coronary arteries; NR [8] ¼ old boy operated in 1994. The second patient was a 44- day-old girl operated in 2004. Both were weaned off of Chen Thrupp et al Fricke et al Qamar et al Metton et al Table 1. Current Studies on Outcomes of Children with Intramural Coronaries After the Arterial Switch Operation Author Study Period IMCA the left ventricular assist device in 2 days. In comparison, Ann Thorac Surg FRICKE ET AL 727 2016;101:725–9 OUTCOMES OF ASO IN PATIENTS WITH INTRAMURAL CORONARY ARTERIES CONGENITAL HEART Fig 1. (A–F) Intramural course of the left coronary artery (LCA) was most common (n ¼ 27) and in most patients (n ¼ 17) the intramural LCA came from sinus 2 (A and D). Intramural right coronary artery (RCA) was encountered in 2 children (E and G). (Ao ¼ aorta; LAD ¼ left anterior descending coronary artery; LCx ¼ left circumflex coronary artery; PA ¼ pulmonary artery.) of the remaining 647 patients, with simple TGA (n ¼ 591) CORONARY SURVEILLANCE.
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