(12) Patent Application Publication (10) Pub. No.: US 2007/0116729 A1 Palepu (43) Pub

US 20070116729A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2007/0116729 A1 Palepu (43) Pub. Date: May 24, 2007

(54) LYOPHILIZATION PROCESS AND (52) U.S. Cl...... 424/400; 34/287: 514/35; PRODUCTS OBTANED THEREBY 514/263.34; 514/291; 514/192: 514/200: 514/282; 514/254.07; (76) Inventor: Nageswara R. Palepu. Mill Creek, WA 514/304: 514/649 US (US) (57) ABSTRACT Correspondence Address: Alyophilization process which comprises dissolving a mate Irving M. Fishman rial in one or more solvents for said material to form a c/o Cohen, Tauber, Spievack & Wagner Solution; forcing said material at least partially out of Suite 2400 Solution by combining the solution and a non-solvent for the 420 Lexington Avenue material, which non-solvent is miscible with the solvent or New York, NY 10170 (US) solvents used and wherein said non-solvent is volatilizable under freeze-drying conditions. In addition, for hydrophobic (21) Appl. No.: 11/282,507 and/or lipophilic materials, the anti-solvent can be omitted, and the solution of the material in the solvent can be (22) Filed: Nov. 18, 2005 subjected directly to freeze drying. The lyophilizates can then be reconstituted with typical aqueous diluent in the case Publication Classification of hydrophilic materials. Hydrophobic and or lipophilic materials can be initially reconstituted with propylene glycol (51) Int. Cl. and/or polyethyleneglycol to form a high concentration A6 IK 9/00 (2006.01) solution therein and this is further diluted for use with a F26B 5/06 (2006.01) diluent of Intralipid, plasma, serum, or even whole blood. US 2007/01 16729 A1 May 24, 2007

LYOPHILIZATION PROCESS AND PRODUCTS come out of solution during the process of cooling or OBTANED THEREBY freezing. For example, if one were to prepare a solution at its saturation concentration, the dissolved solid could pre CROSS-REFERENCE TO RELATED cipitate during the freezing process. Depending upon the APPLICATIONS Solvent or solvent combination used, there may be some liquid portion that does not freeze, but remains liquid and is 0001. Not applicable. distributed within the otherwise frozen mass. The applica tion of vacuum pressures then permits the removal of STATEMENT REGARDING unfrozen liquids first, followed by the sublimation of frozen liquid components, leaving behind a purer, dried product. In FEDERALLY SPONSORED RESEARCH OR Some techniques, the freezing process is done slowly so that DEVELOPMENT crystallization takes place substantially before the solvent is 0002) Not Applicable frozen. In other techniques, the freezing step is performed rapidly to freeze the solvent before appreciable crystalliza FIELD OF THE INVENTION tion has occurred. In still other techniques, after freezing has taken place, addition of a small degree of heat to warm the 0003. The present invention relates to methods of pre frozen mass slightly permits the frozen liquid components to paring lyophilizates, especially those free of undesired extra Sublimate more readily. These same techniques may be components. The invention further relates to obtaining lyo applicable to situations when Suspensions, emulsions, and philizates of amorphous/crystalline solids that are rapidly complex formulations are involved, except that the filtering reconstitutable. The invention further relates to the materials step may not be Suitable because it may remove active or resulting from the novel lyophilization techniques presented other auxiliary components which are intended to be herein. present. BACKGROUND OF THE INVENTION 0006 Unfortunately, the range of acceptable materials for use in pharmaceuticals that are intended for parenteral 0004 Freeze-drying or lyophilization has been widely administration, is not as large and not so accommodating. used for a number of decades in pharmaceutical, food, and For example, emulsions where the freeze-drying process chemical industries. Freeze-drying is particularly desirable leaves the emulsifier and/or the oil phase present in the in situations where a pharmaceutical or other material is lyophilizate would generally not be acceptable from an required to be dried or dehydrated or desolvated, but is intravenous injection point of view. Similarly, Suspending sensitive to the application of heat for the purpose of drying. Many compounds, when exposed to the typically employed agents would also not be desirable. Thus, it is clear that an drying temperatures of non-freeze drying techniques, alternate lyophilization procedure that could eliminate the decompose, degrade, or volatilize away, resulting in an use of undesirable auxiliary agents to a larger degree than is undesirable product. To recognize the large number of presently available is desirable and sought after. applications to which freeze-drying has been adapted, one 0007 Although the prior art is replete with references to need only run a simple search of the US Patent and Trade freeze-drying and lyophilization, most literature refers to the mark Office patent databases for the term “freeze drying technique in a general manner Such as “the material is and/or “lyophilization', which as of October 2005, returns freeze-dried as commonly practiced in the art” and other over 3000 hits and covers a wide range of active agents and general statements of similar description. Virtually all of the other materials. references that do describe the details of the lyophilization 0005. In general, the freeze-drying or lyophilization tech process make no mention of nor Suggestion of the use of an nique is to dissolve, Suspend, or emulsify a compound or anti-solvent or non-solvent. Most references refer to clear formulation; freeze the resultant Solution, Suspension, or Solutions, solvents and co-solvents being used to obtain emulsion; and then to apply a vacuum thereto to Sublimate/ clarity or near clarity, with the solution then being filtered. evaporate the solvents and other liquids in the frozen mass Most references involving lyophilization, when discussing used to dissolve, Suspend or emulsify the material. In many Solvents, refer to aqueous materials. applications, the use of auxiliary agents to create Suitable 0008 Representative (non-exhaustive) patents and appli Solutions, Suspensions, and emulsions is not of significant cations which are of note include the following, all of which concern. This is especially So where the auxiliary agent is are incorporated herein in their entirety. U.S. 2005/0049209 acceptable to be present in the end product, as in the use of discusses freeze-drying of emulsions. U.S. Pat. No. 6,770, auxiliary food ingredients in freeze dried foods. Similarly, 678 discusses that for freeze drying purposes it is desirable where pharmaceuticals are intended for oral ingestion, a to have the solution concentration as high as possible, but wide range of auxiliary pharmaceutically acceptable agents often the high concentration leads to crystals forming during may be used to aid in the preparation of lyophilized active the cooling step, which the reference states is undesirable. compounds or formulations containing Such active com U.S. 2004/0063792 mentions freeze-drying sertraline from a pounds. In most freeze-drying processes, a clear Solution of number of solvent/co-solvent combinations. U.S. 2004/ the material to be freeze dried is obtained, if possible. This 0043042 discusses micro-lyophilization. U.S. 2003/ is then usually filtered aseptically to remove any extraneous 0229027 mentions freeze-drying canabinoids from solvent Solids and microorganism, and the filtered solution is filled mixtures in the presence of certain sugars. U.S. 2003/ into glass vials and cooled in a lyophilization chamber 0202978 discusses spray freeze-drying. U.S. 2002/0010357: whereby the dissolved solids generally freeze together with U.S. Pat. No. 6,384,259; U.S. Pat. No. 6,407.278; U.S. Pat. the freezable liquid components, but may, depending upon No. 6,841,545; and U.S. Pat. No. 6,489,312 all relate to concentration and the rate of the freezing process, begin to amifostine lyophilizates. U.S. Pat. No. 6,566,329 discusses US 2007/01 16729 A1 May 24, 2007 precipitating human growth hormone out of solution by 0020. A further object of the invention is provide new, adjusting the pH to the isoelectric point and then freeze simplified lyophilization procedures for lipophilic and/or drying the result. U.S. Pat. No. 5,731.291 discusses using a hydrophobic materials, with or without the use of anti Solvent (water) and a second agent that Sublimates at -40° Solvents. C. in a lyophilization process. WO99/30688 discusses using an accelerant excipient to enhance the rate of Solvent Sub 0021. An even further object of the invention is to limation. WO2004/0398.04 discusses freeze-drying moxi provide novel lyophilizates of lipophilic and/or hydrophobic floxacin from water. The specification mentions that it can materials. also be obtained by use of an anti-solvent followed by 0022. Still a further object of the invention is to provide filtration, decantation, or centrifugation. There is no sugges novel reconstitution methods for lyophilizates of lipophilic tion that the moxifloxacin obtained from the solution by use and/or hydrophobic materials. of an anti-solvent then be subjected to freeze drying. U.S. 0023. An even further object is to provide a rapidly 2003/082236 discusses use of a supercritical anti-solvent. dissolving end-used product that is Suitable for use in delivering single unit dosages of in excess of hundreds of OBJECTS OF THE INVENTION milligrams. 0009. It is therefore an object of the invention whereby a hydrophilic or a hydrophobic material may be lyophilized 0024. Still other objects of the invention will be apparent using a minimum number of auxiliary materials. to those of ordinary skill in the art. 0010. It is another object of the invention to prepare BRIEF SUMMARY OF THE INVENTION lyophilizates of water sensitive materials. 0025 These and other objects of the invention are sur 0011. It is still another object of the invention whereby an prisingly achieved by a process which comprises dissolving amorphous material may be recovered via lyophilization the material in one or more solvents for said material to form with or without the use of auxiliary agents. a solution; forcing said material at least partially out of 0012 Still another object of the invention is to provide a Solution by combining the solution and a non-solvent for the non-aqueous lyophilization technique which includes sev material, which non-solvent is miscible with the solvent or eral organic Solvents which have not been previously known solvents used and wherein said non-solvent is volatilizable for use in the lyophilization process art. under freeze-drying conditions or optionally seeding the solution before or during the step of forcing it out of 0013. It is still another object of the invention whereby a Solution; freezing the result thus far; and applying a vacuum crystalline hydrate and/or amorphous material may be to dry the frozen result. For hydrophilic substances water is recovered via lyophilization without the use of auxiliary frequently the primary solvent and forms the frozen mass agents while simultaneously avoiding the use of ethanol. while any co-solvent and the anti-solvent may or may not 0014) An even further object of the invention is to freeze during the freezing step. For lipophilic or hydropho provide a method of obtaining a Substantially pure, readily bic materials, water is frequently the anti-solvent and it is the reconstitutable hydrophilic or hydrophobic or lipophilic Solvent and potential co-solvent which may or may not material substantially free of auxiliary materials. freeze during the freezing step. Either way, the dissolved material is forced out of solution by the anti-solvent, the 0015. An even further object of the invention is to result Subjected to freezing temperatures to form a frozen provide a method of obtaining a Substantially pure, readily mass, and the frozen mass Subjected to vacuum pressures to reconstitutable hydrophilic or hydrophobic or lipophilic result in a lyophilizate. In addition, for hydrophobic and/or material substantially free of auxiliary materials which when lipophilic materials, the anti-solvent can be omitted, and the reconstitutes with pharmaceutically acceptable diluent will solution of the material in the solvent can be subjected result in either a clear Solution or a micellar solution or an directly to freeze drying. The lyophilizates can then be emulsion or a Sub-micron Suspension. reconstituted with typical aqueous diluent in the case of 0016. An even further object of the invention is to hydrophilic materials. Hydrophobic and or lipophilic mate provide a method of obtaining a Substantially pure, readily rials can be initially reconstituted with propylene glycol reconstitutable material containing a hydrophobic or lipo and/or polyethyleneglycol to form a high concentration philic Substance that further contains at least one of a solution therein and this is further diluted for use with a solubilizer or a surfactant or combinations thereof which diluent of Intralipid, plasma, serum, or even whole blood. material, upon reconstitution with pharmaceutically accept able diluent will result in either a clear solution or a micellar DETAILED DESCRIPTION OF THE Solution or an emulsion or a Sub-micron Suspension. INVENTION 0017. Yet another object of the invention is to provide a 0026. The present invention is directed to a method for method for obtaining an amorphous lyophilizate which is freeze-drying or lyophilizing a material which may be (i) stable in the presence of moisture. hydrophilic or (ii) hydrophobic and/or lipophilic. Generally when the material is hydrophilic, the material is also sensi 0018. An even further object of the invention is to tive to the presence of moisture. The material is usually a provide a method of obtaining crystalline hydrate lyo Substantially pure compound, preferably a pure compound, philizates that are stable in the presence of moisture. but may also be a simple or complex mixture. The material 0019. Yet another object of the invention is to prepare is dissolved in a solvent therefor, preferably without, but stable lyophilizates of water sensitive materials from a potentially with, one or more co-solvents so as to obtain a lyophilization process that includes water. substantially clear, preferably clear, solution of said material US 2007/01 16729 A1 May 24, 2007

therein. Solvent for the material is one which can be “pure' if it meets the relevant industry standard for purity. removed in a freeze-drying process, i.e., one that is volatile Such industry standards include standards, such as “Reagent or Sublimates at the temperature and pressure used in the Grade', etc. primary drying step with any residual amount being remov able during a secondary drying step. If desired, the Solution 0028 Compounds that can benefit from the present may be filtered aseptically before combining it with the invention include, but are not limited to, pharmaceutically anti-solvent which is also filtered aseptically, to remove any active compounds, Veterinary compounds, food materials, dyes, household and industrial chemicals, etc. Selected, undesired (or undissolved) materials as well as microorgan non-limiting, representative compounds include hydrophilic isms from the material containing Solution and anti-solvent. materials as well as hydrophobic/lipophilic materials. Vari Alternatively, a pH adjustment can be effected prior to the ous hydrates and Solvates in various polymorphic forms of optional filtration in order to aid stability and/or solubility, Such materials are also suitable. Conversion from hydro and/or post filtration to aid stability. Preferably, a pH adjust philic to hydrophobic materials may often be accomplished ment for stability purposes, when used, is conducted before by a pH change between a charged species and an uncharged the optional filtration step. The pH adjustment can be one. Such as for example conversion between a free acid or accomplished by the addition of an acid or a base or a buffer. base (less water soluble) and a salt thereof (more water Once the material to be lyophilized is in solution, the soluble). If the solubility shifts sufficiently, the solvents/co Solution is subjected to an anti-solvent for the material (or a solvents for one form can become the anti-solvent for the mixture of anti-solvents for the material). The anti-solvent other form and the anti-solvents for the first form can for the material is volatile or sublimates under lyophilization become the solvents for the latter. Thus, the invention is conditions (i.e., at the pressure and temperature used in the applicable to free acids, free bases, their salts, and Zwitte primary drying step). If the anti-solvent doesn’t freeze under rionic species where appropriate, and those materials having lyophilization conditions, special lyophilization techniques a permanent charge such as betains and Sultanes, and other are adopted (such as the inclusion of a liquid nitrogen trap quaternium compounds. A general guideline as to the hydro between the condenser and vacuum pump, and the like) to philic VS hydrophobic nature of compounds can be gleaned remove the anti-solvent. The anti-solvent is not a solvent for from a variety of methods known in the art. A simple system is the simple solubility of the compound in question in water the material and the material is essentially insoluble in the and is designated by the terms “very soluble' (1 part anti-solvent but is miscible with the solvent used to dissolve solute/less than 1 part water), “freely soluble” (1 part (and any co-solvent that is present to dissolve) the material solute? 1 part water to 1 part solute/10 parts water); “soluble' so that upon its addition, a Substantial portion preferably 1 part solute/10 parts water to 1 part solute/30 parts water); substantially all, most preferably all, of the material is forced “sparingly soluble” (1 part solute/30 parts water to 1 part out of Solution and forms a suspension or slurry of Solid solute/100 parts water); “slightly soluble” (1 part solute/100 particulates in the complex solvent/optional co-solvent/anti parts water to 1 part solute/1000 parts water): “very slightly solvent mixture. Optionally before or during, preferably soluble” (1 part solute/1000 parts water to 1 part solute/ before or at the beginning of the step when the material is 10000 parts water); and “practically insoluble' or forced out of solution, the solution may be seeded with a “insoluble” (1 part solute/>10000 parts water). All of the portion of the material that is in the desired solid form to designations “very soluble”, “freely soluble”, “soluble'. enhance formation of the appropriate form of the material. “sparingly soluble' and “slightly soluble' indicate materials Optionally, if desired, the result can then be filtered, which can be considered hydrophilic for the present inven decanted, etc. to separate a portion of the solvent/optional tion. The designations “very slightly soluble”, “practically co-solvent/anti-solvent mixture from the precipitated solids. insoluble', and “insoluble' can be considered hydrophobic When such a separation technique is used, the separated for purposes of the invention. The above classification solids are still wet with the solvent/optional co-solvent/anti system is used detailed in Remington: The Science and solvent mixture. Whether or not the post precipitation sepa Practice of Pharmacy 19" Ed., Mack Publishing co., Easton, ration technique is used, the resulting wet solids (suspen Pa. 1995, Page 195, and is described in the United States Pharmacopoeia. A second system is by a determination of sion, slurry, etc.) are then frozen and the frozen solid is dried the partition coefficient, P. defined as the ratio of the con by the application of vacuum to remove the solvent, the centration of a material in octanol to the concentration in co-solvent, and the anti-solvent. In some embodiments, one water in an octanol/water system at equilibrium at 25° C. or more (but not all) of the solvent/optional co-solvent/anti Generally, values for P are given as log P (see Handbook of solvent of choice does not freeze at the freezing step Chemistry and Physics 86" Ed. 2005-2006 at Pages 16-41 to temperature allowed by the lyophilizer. When this is the 16-45 and Remington: The Science and Practice of Phar case, special anti-solvent removal conditions need to be macy 19" Ed., Mack Publishing Co., Easton, Pa. 1995, used. These special removal conditions include the use of a Pages 158-159). Values of P-1 (log P is negative) are liquid nitrogen trap and other similar techniques known in clearly hydrophilic. Values of Psal are generally hydropho the art. bic. However, since this measure is in the octanol/water system, it is not absolutely controlling in the invention, but 0027. The material may be selected from a wide range of merely indicative of whether a particular material is a likely compounds and compositions, but is preferably a Substan hydrophilic or likely hydrophobic one for initial consider tially pure compound, most preferably a pure compound, ation of the solvent, co-solvent, and anti-solvent to use. where "pure' indicates as reasonably pure as can be Another guideline useful for consideration of the hydro obtained using at least commercially reasonable standards philic or hydrophobic nature of the material is the hydro and tolerances. Thus, a product is “pure' for purposes of this philic-lipophilic balance (HLB) system. (See Remington invention if (in the context of pharmaceutical materials) it is above, pages 287-288). Although the HLB system was sufficiently pure to meet Federal Food and Drug Adminis developed for Surface active agents, it does give another tration purity standards. If the product in question is other guideline as to the hydrophilic nature or hydrophobic nature than an end use pharmaceutical, the product is considered of a material, with hydrophilic materials having an HLB US 2007/01 16729 A1 May 24, 2007 greater than about 10 and hydrophobic materials having an (particularly as the hydrochloride Salt and especially as the HLB value generally below about 10. Once a potential monohydrate form), lincomycin (particularly as the hydro Solvent and potential anti-solvent are selected however, chloride Salt and especially in the monohydrate form), confirmation should be sought that the chosen anti-solvent menadiol (particularly as the sodium diphosphate Salt and does substantially push the material out of solution in the especially in the hexhydrate form), neropenam (especially as chosen solvent or solvent/co-solvent mixture. The more the trihydrate), metoclopramide (particularly as the hydro efficiently and completely the anti-solvent pushes the mate chloride Salt and especially in the monohydrate form), rial out of solution, the better the invention should be morphine (particularly as the Sulfate Salt and especially in expected to give the desired results. the pentahydrate form), nafcillin (particularly as the sodium 0029. Useful compounds which can be prepared in lyo salt and especially in the monohydrate form), norepineph philizate form according to the invention (generally include, rine (particularly as the bitaritrate salt and especially in the but are not limited to, end use acceptable salts, amides monohydrate form), ondansetron (particularly as the hydro thereof, sulfonamides thereof, carbamates thereof, esters chloride salt and especially in the dihydrate form), oxacillin thereof and phosphoesters thereof, hydrates and solvates (particularly as the Sodium salt and especially as the mono thereof, and crystalline polymorphs and amorphous forms hydrate), oxytetracycline (especially as the dihydrate), pip thereof, and racemates, enantiomers, and diastereomers eracillin (especially as the monohydrate, Scopolamine (par thereof). In the following exemplary list, most of the com ticularly as the hydrobromide Salt and especially as pounds are pharmaceutically or veterinary acceptable com trihydrate), spectinomycin (particularly as the dihydrochlo pounds. Thus, the salt or ester is preferably those that are ride and especially as the pentahydrate). Succinylcholine acceptable in these uses. However, if the lyophilizate will be (particularly as the chloride salt), theophylline (especially as further modified before being used as a pharmaceutical or the monohydrate), thiothixene (particularly as the dihydro veterinary material, the salt or ester is not so limited. In chloride and especially as the dihydrate), tubocurarine (par addition, the following more extensive list, lists one moiety ticularly as the hydrochloride salt and especially as the for the free base, the free acid, and all salts thereof, so that pentahydrate form), moxifloxacin, tacrolimus, itraconazole, the absence of a particular salt or of the free acid or free base argatroban, posaconazole, Voraconazole, docetaxel, fludara when another is present, should be construed to include the bine, glatiramer acetate, gemcitabine, irinotecan, epopros listing of all such suitable forms. Similarly, not all pharma tenol, and 7-ethyl-10-hydroxy camptothecin. ceutically acceptable esters are indicated, and again, the 0031. A more complete list of compounds, most of which listing of a non-esterified form should be deemed to include are pharmaceutical or veterinary, which can be utilized in the the Suitable esterified counterparts. In addition, compounds present invention includes, but is not limited to: abacavir, having a quaternary ammonium are listed only as the abamectin, abanoquil, abaperidone, abarelix, abecamil, abi primary species without reference to the counterion (i.e., raterone, abitesartan, ablukast, abunidazole, acadesine, benzalkonium, rather than benzalkonium chloride, etc), but acamprosate, acaprazine, acebrochol, acebutolol, acecain all suitable counterions are deemed to be within the scope of ide, acecarbromal, aceclidine, aceclofenac, acedapsone, ace the invention. diasulfone, acedoben, acefluranol, acefurtiamine, acefylline clofibrol, acefylline piperazine, aceglatone, aceglutaminde, 0030. In light of the size of the more extensive list, the acemetacin, aceneuramicacid, acenocoumarol, acepeprone, inventor presents his preferred compounds of interest, but acepromazine, aceprometazine, acequinoline, acesulfame, this is only in the interest of clarity and should not be taken acetaminosalol, acetanilide, acetarSone, acetaminophen, as a limitation on the broader Scope of the invention. acetazolamide, acetiamine, acetiromate, acetohexamide, Preferred compounds for use as the material to be lyo acetophenaZone, acetophenetidin, acetorphine, acetosul philized according to the invention include antibiotics fone, acetriozoic acid, acetylcysteine, acetyldigitoxin, (including penicillins, cephalosporins, tetracyclines, mac acetylleucine, acetyltributyl citrate, acetyltriethyl citrate, rolides, etc) Xanthines, anesthetics (including barbiturates, acevaltrate, acexamin acid, acifran, acipimox, acitaZanolast, narcotics, and the "caines”), anti-emetics, anti-cancer acitemate, acitretin, acivicin, alcantate, aclarubicin, aclato agents, etc. A specifically preferred group of compounds nium napadisilate, acolbifene, aconiazide, aconitine, acotia includes, but is not limited to, alfentanil (particularly the mide, acoXatrine, acreoZast, acridorex, acriflavine, acri hydrochloride especially the monohydrate), amifostine (par hellin, acrisorcin, acrivastine, acroinonide, acronine, ticularly the amorphousand trihydrate forms), aminophyllin actaplanin, actarit, actinoquinol, actisolide, actodigin, acy (particularly the dehydrate form), amoxicillin (particularly clovir, adafenoxate, adamexine, adapalene, adaprolol, ada the trihydrate form), amplicillin (especially the trihydrate tanserin, adefovir, adekalant, adelmidrol, ademitrionine, form), bupivacaine (especially the hydrochloride salt and adenosine, adibendal, adicillin, adimolol, adinazolam, particularly the monohydrate form), caffeine (especially the adiphenine, aditeren, aditoprim, adosopine, adoZelesin, adrafinil, adrenalone, adrogolide, afalanine, afeletecan, aflo monohydrate form), cefepime (especially the hydrochloride qualone, afovirsen, afurolol, aganodine, aglepristone, ago salt and particularly the monohydrate form), ceftazidime melatine, aklomide, alacepril, alafosfalin, alagebrium, ala (especially the pentahydrate form), ceftriaxone (especially mecin, alamifovir, alanine, alanosine, alaproclate, the 3.5 hydrate form), cephradine (particularly the mono and alatrofloxacin, alazanine triclofenate, albaconazole, dihydrate forms), chromic chloride (especially the hexahy albendazole, albuterol, albutoin, alclofenac, alclometaSone, drate form), clindamycin (especially the monohydrate alcloxa, alcuronium, aldioxa, aldosterone, alemcinal, allen form), codeine, cyclophosphamide, cysteine, dextrose, dox dronic acid, alentemol, alepride, alestramustine, aletamine, apram (particularly the hydrochloride salt and especially the alexidine, alexitol, alexomycin, alfacalcidol, alfadex, alfida monohydrate form) doxycycline (especially the monohy lone, alfaprostol, alfatradiol, aldaxalone, alfentranil, alflu drate form), edetate (especially the dihydrate form), hyos Zosin, algeldrate, algestone, alibendol, aliconazole, cyamine (especially the Sulfate salt and the dihydrate form), alifedrine, alifurane, alilusem, alimadol, alinastine, alini levorphanol (especially as the dihydrate form), lidocaine dine, alipaminde, alliskiren, alitame, alitretinoin, alizapride, US 2007/01 16729 A1 May 24, 2007

alletorphine, allobarbitol, allocamide, allocupreide, allom quone, atracurium, atrasentan, atraleuton, atrimustine, atri ethadione, allopurinol, allylestrenol, allylprodine, almecil nositol, atromepane, atropine, atropine oxide, auranofin, lin, almestrone, alminoprofen, almitrine, almokalant, almot aurothioglucose, avanafil, avasimibe, avicatonin, avalamy riptan, almoxatone, almurtide, alnespirone, alniditan, cin, aviptadil, avitriptan, avizafone, avobenzone, azoparcin, alonacic acid, alonimid, aloracetam, alosetron, alovudine, avorelin, avridine, axamozide, axitirome, axomadol, azabon, aloxidone, aloxiprin, aloxistatin, aloZafone, alpertine, alpha aZabuperone, azacitidine, azacitidine, azaclorzine, azacona meprodine, alphamethadol, alphamethyldopa, alphaprodine, Zole, azacoSrterol, azacyclonol, aZaftozine, azalanstat, aza alpidem, alpiropride, alprafenone, alprazolam, alprenolol. lomycin, azaloxan, azamethiphos, azamethonium, azamulin, alprenoXime, alprostadil, alrestatin, altanserin, altapizone, aZanator, azanidazole, azaperone, azapetine, azaquinzole, alteconazole, althiazide, altinicline, altoqualiine, altreno azaribine, azarole, azaserine, aZasetron, azaspirium, azas gast, altretamine, alvemeline, alverine, alvimopan, alvo tene, azatadine, azathioprine, azelaic acid, azelastine, aZelin cidib, amadinone, amafalone, amanozine, amantadine, nidipine, azepexole, azepindole, azetepa, aZetirelin, azidam amantocillin, ambamustine, ambasilide, ambazone, fenicol, azidocillin, azimexon, azimilide, azintamide, ambenonium, ambenoxan, ambomycin, ambrisentan, aZipramide, azithromycin, azlocillin, azlocillin, azolimine, ambroXol, ambruticin, ambucaine, ambucetamide, ambu aZosemide, aztomycin, aztreonam, aZumolene, bacampicil phylline, ambuside, ambutonium, amcinafal, amcinafide, lin, bacitracin, baclofen, bacmecillinam, bakeprofen, bala amcinonide, amdinocillin, amdoxovir, ambucort, amedalin, glitaZone, balaZipone, balofloxacin, balsalazide, bamalu amelometaSone, ameltolide, amelubant, ameSergide, amet Zole, bamaquimast, bambermycin, bambuterol, bamethan, antrone, amethocaine, ameZapine, ameZinium, amfenac, bamifylline, bamipine, bamirastine, bamidazole, banox amfepentorex, amfetaminil, amflutizole, amfonelic, amicar antrone, baduiloprim, barbexaclone, barbital, barixibat, bar balide, amicloral, amicycline, anidantel, amidapsone, mastine, barnidipine, barucainide, barusiban, basifungin, amidephrine, amiflamine, amifloverine, amifloxacin, ami batalbulin, batanopride, batebulast, batelapine, batilol, bati fostine, amiglumide, amikacin, amikhelline, amiloride, mastat, batoprozine, baxitoizine, baZedoxifene, bazinaprine, amiloxate, aminacrine, amindocate, amineptine, aminoglu becanthone, becatecarin, becliparcil, beclamide, beclicona tethimide, aminohippuric acid, aminolevulinic acid, ami Zole, beclobrate, beclomethasone, beclotiamine, befetupi nometradine, aminopentamide, aminophenaZone, amino tant, befiperide, befloxatone, befunolol, befuraline, bekana phylline, aminopromazine, aminopterin, aminopyrine, mycin, belaperidone, belarizine, belfosdil, belotecan, aminoquinol, aminoquinuride, aminorex, aminosalicylic beloxamide, beloxepin, bemarinone, bemegride, acid, aminothiazole, amiodarone, amiperone, amphenazole, bemesetron, bemetizide, beminafil, bemiparin, bemetradine, amipizone, amiprolose, amiquinsin, amisometradine, bemoradan, bemotrizinol, benactyzine, benafentrine, amisulprode, amiterol, amithioZone, amitivir, amitraz, ami benapry Zine, benaxibine, benazepril, bencianol, bencisteine, triptyline, amitriptyinoxide, amiXetrine, amlexanoX, amlin benclonidine, bencyclane, bendacalol, bendamustine, tide, amlodipine, amocarzine, amodiaquine, amolanone, bendazac, bendazol, benderizine, bendroflumethazide, amonafide, amoproxan, amopyroquine, amorolfine, amos benethamine penicillin, benexate, benfluorex, benfosformin, canate, amosulatol, amotoSalen, amotriphene, amoxapine, benfotiamine, benflurodil, benhepazone, benidipine, ben amoxecaine, amoxicillin, amoxydramine, amperozide, moxin, benolizime, benorilate, benorterone, benoxifos, anphechloral, amphenidone, amphetamine, amphomycin, benoxaprofen, benoximate, benpenolisin, benperidol, ben amphotalide, amphotericin, amplicillin, ampiroxicam, properine, benrixate, bensalan, benserazide, benSuldazic amprenavir, amprolium, ampyrimine, ampyZine, amduinate, acid, bentazepam, bentemazole, bentiamine, bentipimine, amrubicin, amsacrine. amtolimetin, amustaline, amylobar bentiromide, bentoquatam, benurestat, benzalkonium, ben bital, angestone, anagrelide, anakinra, anaritide, anastrozole, Zarone, benzbromarone, benzestrol, benzethidine, benzetho anatibant, anaxirone, anazocine, anazolene, ancarolol, ancit nium, benzetimide, benzilonium, benzindopyrine, benzio abine, andolast, androstenediol, androstenedione, andu darone, benzmalecene, benznidazole, benzobarbital, lafungin, anecortave, anetholtrithion, angiotensin amide, benzocaine, benzoclidine, benzoctamine, benzodepa, ben andidoxamine, anidulafungin, anilamate, anilleridine, anilo Zododecinium, benzonatate, benzopyrronium, benzo pam, anipamil, aniracetam, anirolate, anisacril, anisindione, quinonium, benzotript, benzoxiquine, benzoxonium, ben anisopirol, anisotropine, anisperimus, anitraZafen, anpirto Zoylpas, benzphetamine, benZpiperylon, benzpyrinium, line, ansoxetine, antafenite, antazoline, antazonite, anthel benzquercin, benzquinamide, benzthiazide, benztropine, mycin, anthralin, anthramycin, antipyrine, antrafenine, apa benzydamine, benzylhydrochlorothiazide, benzylpenicillin, doline, apafant, apalcillin, apaxafylline, apaziquone, benzylsulfamide, bepafant, beperidium, bephenium, bepias apaZone, apicycline, aplindore, apomorphine, apovincam tine, bepridil, beractant, beraprost, berberine, berefrine, ber ine, apraclonidine, apramycin, aprepitant, aprakalim, aprin genin, berlafenone, bermoprofen, bertosamil, berupipam, dine, aprinocarsine, apofene, aprosulate, aptazapine, apti bervastatin, berythromycin, besigomsin, besipirdine, beson ganel, aptocaine, aranidipine, aranotin, arbaprosil, prodil, besulpamide, besunide, beta carotene, betacetylmeth arbekacin, arbutamine, arclofenin, ardacin, ardeparin, adol, betahistine, betaine, betameprodine, betamethadol, arecoline, arfalasin, arfendazam, arformoterol, argatroban, betamethasone, betamicin, betamipron, betaprodine, betax argimesna, argipressin, argiprestocin, arlidone, arimoclo olol, betazole, bethanacol, bethanidine, betiatide, betox mol, aripiprazole, armodafinil, arnolol, arofylline, artinolol. ycaine, bevantolol, bevonium, beXarotene, bexlosteride, arprinocid, arpromidine, arsanilic acid, arteflene, artemether, bezafibrate, beztiramide, bialamicol, biapenem, bibeZonium, artemisinin, artemotil, artenimol, artesunate, articaine, artil bibrocathol, bilcalutamide, bici fadine, bicoldil, biclofibrate, ide, arundic acid, arZoxifene, ascorbic acid, arsenapine, biclotymol, bicoZamycin, bidimazium, bidisomide, aseripide, asimadoline, asobamast, asocainol, asoprisnil, bietamiverine, bietaserpine, bifemelane, bifepramide, aspartame, aspartocin, asperlin, aspirin, aspoxicillin, astemi bifeprofen, bifeprunox, bifluranol, bifonazole, bilastine, Zole, astromicin, asulacrine, atameStane, ataprost, ataqui bimakalim, bimatoprost, bimoclomol, bimosiamose, bin mast, atavanavir, atenolol, atevirdine, atibeprone, atilmotin, darit, binedaline, binfloxacin, binfibrate, biniramycin, bini atipamezole, atipromod, atiprosin, atizoram, atliprofen, ato Zolast, binodenosine, binospirone, bioallethrin, botin, bipe calcitol, atolide, atomoxetine, atorvastatin, atosiban, atova namol, biperiden, biphenamine, biricodar, biriperone, US 2007/01 16729 A1 May 24, 2007

bisacodyl, bisantrene, bisaramil, bisbendazole, bisben carebastine, carfentanil, carfimate, cargutocin, cariporide, tiamine, bisbutiamine, bisdequilinium, bisfenaZone, bisfen carisoprodol, carmantadine, carmofur, carmoterol, carmus tidine, bisnafide, bisorbin, bisoctriazole, bisoprolol, bisorcic, tine, carnidazole, carnitine, carocainide, caroverine, caroX bisoxatin, bispyrithione, bithonol, bithionoloxide, butipa aZone, carperidine, carperitide, carperone, carphenazine, Zone, bitolterol, bitoscanate, bivalirudin, bizelesin, bleomy carpindolol, carpipramine, carpraZidil, carprofen, capro cin, blonanserine, bluenSomycin, bofumustine, bolandiol. nium, carsalam, carsatirin, cartasteine, cartaZolate, carteolol. bolasterone, bolazine, boldenone, bolenol, bolmantalate, carubicin, carumonam, carvedilol, carvotroline, carZelesin, bometolol, bopindolol, bornaprine, bornaprolol, borelone, carzenide, casanthranol, casokefaminde, caspofungin, borocaptaine, bortezomib, bosentan, botiacrine, boxidine, cathine, cathinone, cebaracetam, cedefingol, cefaclor, brallobarbital, brasofensine, brazergoline, brefonalol, cefadroxil, cefalonium, cefaloram, cefamandole, cefaparole, bremazocine, brequinar, bretazenil, bretyllium, brifentanil, cefatriazine, cefazaflur, cefaZedone, cefazolin, cefbupera brimonidine, brinaZaprone, brindoXime, brinzolamide, Zone, cefanel, cefcapene, cefclidin, cefdaloXime, cefdinir, brivudine, brobactam, broclepride, brocrestine, brocrinat, cefditoren, cefedrolor, cefempidone, cefepime, cefetamet, brodimoprim, brofaromine, brofoxine, brolaconazole, bro cefetecol, cefetriaole, cefivtril, cefixime, cefimatilen, cef lamfetamine, bromadoline, bromamid, bromazepam, bro menoxine, cefimepidium, cefimetazole, ceminox, cefodizime, mchlorenone, bromebric acid, bromerguride, bromete cefonicid, cefoperaZone, ceforanide, cefoselis, cefotaxime, namine, bromfenac, brom hexene, bomindione, cefotetan, cefotiam, cefoVecin, cefoxazole, cofoxitin, cefo bromisovalum, bromociclen, bromocriptine, bromodiphe Zopran, cefpimizole, ce?piramide, cefpodoxime, cefprozil, nylhydramine, bromofenfos, bromofos, bromopride, bro cefauinome, cefrotil, cefroxadine, cefsulodin, cefsumide, moxanide, bromperidol, brompheniramine, broparestrol, ceftazidime, cefteram, ceftezole, ceftibuten, ceftioflur, cefti broperamol, bropirimine, broquinaldol, broSotaminde, broS olene, ceftioxide, ceftioxime, ceftriaxone, cefuracetamime, tallicin, broSuximide, brotianide, brotizolam, brovanexine, cefuroxime, cefuZonam, celecoxib, celgosivir, celiprolol. brovincamine, broxaldine, broXaterol, broxitalamide, broXu cemadotin, cephacetrile, cephadrine, cephalexin, cepha ridine, broxyquinoline, bucainide, bucetin, buciclovir, buci loglycin. Cephaloridine, cephalothin, cephapirin, cepharan llamine, bucindolol, bucladesine, buclizine, buclosaminde, thine, cephradine, cericlamine, cerivastatin, ceronapril, bucloxic acid, bucolme, bucricaine, bucromarone, bucu ceruletide, cetaben, cetalkonium, cetamolol, cetefloxacin, molol, budesonide, budipine, budotitane, budralazine, cethexonium, cethromycin, cetiedil, cetilistat, cetirizine, bufenadrine, bufeniode, bufetolol, bufexamac, bufezolac, cetocycline, cetopheincol, cetotiamine, cetoxime, cetraxate, buflomedil, bufogentin, buformin, bufrolin, bufuralol, bufyl cetrimonium, cetylpyridinium, cevimeline, chaulmosulfone, line, bullaquine, bumadizone, bumecaine, bumepidil, bumet chenodiol, chinofon, chlofibrate, chlophendianol, chlo anide, bumetriazole, bunaftine, bunamidine, bunamiodyl, racyZine, chloralose, chlorambusil, chloramines-T, chloram bunaprolast, bunaZosin, bunitrolol, bunolol, buparvaquone, phenicol, chlorazanil, chlorbenoxamine, chlorbetamide, bupicomide, bupivacaine, bupranolol, buprenorphine, chlorcyclizine, chlordantoin, chlordiazepoxide, chlordimo bupropion, buquinerin, buquinolate, buquiterine, buramate, rine, chlorhexidine, chlorindanol, chlorisondamine, burodiline, buserelin, buspirone, busulfan, butobarbital, chloramadione, chlormerodrin, chlormeZanone, chlormida butacaine, butacetin, butaclamol, butadiaZamide, butafos Zole, chlornaphazine, chloroaZodin, chloroprednisone, chlo fan, butalamine, butalbital, butamben, butamirate, butami roprocaine, chloropyramine, chloroquine, chloroserpidine, sole, butamoxane, butanilicaine, butanserin, butantrone, chlorothen, chlorothiazide, chlorotrianisene, chloroxine, butaperazine, butaprost, butaverine, butedronate, bytenafine, chloroxylenol, chlorphenesin, chlorpheniramine, chlorphe buterizine, butenamate, buthiazide, butibufen, butifrine, noctium, chlorphenoxamine, chlorphentermine, chlorproet butikacin, butilfenin, butinazocine, butinoline, butirosin, hazine, chlorproguanil, chlorpromazine, chlorpropamide, butixirate, butixocort, butobendine, butoconazole, chlorprothixene, chlorpyrifos, chlortetracycline, chlorthali butocrolol, butoctamide, butofiolol, butonate, butopamine, done, chlorthenoxazine, chlorZoxazone, cholecalciferol, butopiprine, butoprozine, butopyrammonium, butorphanol, cholesterol, choline alfoscerate, choline, chromic chloride, butoxamine, butoxylate, butriptyline, butropium, butylsco chromonar, ciadox, ciaftalan, ciamexon, cianergoline, cian polamine, butynamine, buZepide, cabastine, cabergoline, idanol, cianopramine, ciapilome, cicaprost, cicarperone, cactinomycin, cadralazine, cadrofloxacin, cafaminol, ciclactate, ciclafrine, ciclazindol, ciclesonide, clcletanine, cafedrine, caffeine, calcifediol, calciprotriene, calcitriol, cal cicliomenol, ciclonicate, ciclonium, ciclopiroX, ciclo cobutrol, caldaret, caldiamine, caloxetic acid, calteridol. pramine, cicloprofen, cicloprolol, ciclosidomine, cicloti clausterone, camazepam, cambendazole, camaglibose, cam Zolam, ciclotropium, cicloxilic acid, cicloxolone, cicor iverine, camptothecin and its analogues such as 9-amino tonide, cidofovir, cidoxepin, cifenline, cifostodine, camptothecin, 10-hydroxy camptothecin, 7-ethyl-10-hy ciglitaZone, ciheptolane, ciladopa, cilansertron, cilastatin, droxy camptothecin, 9-nitro camptothecin and all other cilaZapril, cilengitide, cilexin, cilnidipine, cilobamine, cilo camptothecin analogues with six, seven and eight membered bradine, cillofungin, cilomilast, cilostamide, ciloStaZol, cilu lactone rings, camonagrel, camo.stat, camylofin, canbisol, previr, cilutazoline, cimaterol, cimemoxin, cimetidine, candesartan, candicidin, candocuronium, candoXatril, can cimetropium, cimicoxib, cimoxatone, cinacalcet, cinalukast, doXatrilat, canertinib, canfosfaminde, cangrelor, cannabinol, cinametic acid, cinamolol, cinanserin, cinaproxen, cin canrenoate, canrenone, capectitabine, capobenate, capobe chophen, cinecromen, cinepazet, cinepazide, cinfenine, cin nic acid, capravirine, capreomycin, capromorelin, caproX fenoac, cinflumide, cingestol, cinitapride, cinmetacin, cin amine, capsaicin, captamine, captodiame, captopril, capu namaverine, cinnamedrine, cinnarizine, cinnofuradione, ride, carabersat, caracemide, carafiban, caramiphen, cinoctramide, cinodine, cinolazepam, cinoquidox, cinoxa carbachol, carbadox, carbamazepine, carbentel, carbasone, cin, cinoxate, cinoXolone, cinoXopazide, cinperene, cinpra carbaspirin, carbazeran, carbazochrome, carbazocine, cabe Zole, cinpropazide, cinpromide, cintaZone, cintriamide, nicillin, carbenoXolone, carbenzide, carbetapentane, carbe cinuperone, cioteronel, cipamfylline, cipemastat, ciprafa tocin, carbidopa, carbimazole, carbinoxamine, carbiphene, mide, cipralisant, cipraZafone, ciprefadol, ciprocinonide, carbofenotion, carboplatin, carboprost, carboquone, car ciprofibrate, ciprofloxacin, ciprokiren, cipropride, ciprocqua bubarb, carburazepam, carbutamide, carbuterol, carcainium, Zone, ciprestene, ciramadol, cirazoline, cirolemycin, US 2007/01 16729 A1 May 24, 2007

cisapride, cisatracurium, cinconazole, cismadinone, cispl thron, dantrolene, dapiprazole, dapitant, dapivirine, dapoX atin, cistinexine, citalopram, citatepine, citenamide, citena etine, dapsone, daptomycin, darbufelone, darenzepine, dar Zone, citicoline, citiolone, cizolirtine, cladribine, clamidoxic glitaZone, darifenacin, darodipine, darunavir, darusentan, acid, clamikalant, clamoxyquin, clanfenur, clanobutin, clan dasantafil, datelliptium, daunorubicin, daxalipram, daZadrol, tifen, clarithromycin, clavulanate, claZolam, clazolimine, dazepinil, dazidamine, daZmegrel, dazolicine, dazopride, claZuril, clebopride, clefamide, clemastine, clemeprol, daZoquinast, daZOXiben, deboxament, debrisoquin, decame clemizole, clenbuterol, clempirin, clentiazem, cletoquine, thonium, decimemide, decitabine, decitropine, declenper clevidipine, clevudine, clibucaine, clidafidine, clidanac, one, declopramide, decloxizine, decominol, decoquinate, clindium, climaZolam, climbazole, climiqualine, clinafloxa dectaflur, deditonium, deferasirox, deferiprone, deferoxam cin, clindamycin, clinofibrate, clinolamide, climprost, clio ine, deflazacort, defosfamine, defoslimod, degarelix, dehy quinol, clioxanide, cliprofen, cliropamine, clobazam, droacetic acid, dehydrocholic acid, dehydroemetine, clobenoside, clobenzepam, clobenorex, clobenztropine, clo delanterone, delapril, delavirdine, delquamine, deergotrile, betasol, clobetaSone, clobutinol, clobuZarit, clocanfamide, delfantrine, delfaprazine, Selmadinone, delmetacin, delimpi clocapramine, clociguanil, clocinizine, clocortolone, clo nol, delorazepam, deloxolone, delprostenate, delucemine, coumarol, clodacaine, clodanolene, clodazon, clodoxopone, dembrexine, demecarium, demeclocycline, demecolcine, clodronate, clofarabine, clofazimine, clofenamic acid, demecycline, demegestone, demelverine, demexiptiline, clofeniclan, clofenetamine, clofenoxyde, clofevine, clofex democonazole, demoxepam, demoxytocin, denatonium, amine, clofeZone, clofibrate, clofibric acid, clofibride, clo denaverine, denbufylline, denipride, denofungin, denopam filium, clofucarba, clofoctol, cloforex, clofurac, clogestone, ine, denotivir, denpidazone, denufosol, denZimol, depe cloguanamil, clomacrin, clomegestone, clometacin, clom lestat, depramine, depreotide, deprodone, deprostil, dep etherone, clomethiazole, clometocillin, clomifenoxide, clo tropine, dequalinium, deracoxib, deramciclane, deriglidole, minorex, clomiphene, clomipramine, clomocycline, clo derpanicaine, derSalazine, desapidin, desciclovir, descino moxir, clonazepam, clonazoline, clonidine, clonitazine, lone, deserpidine, desipramine, deeslanoside, desloratidine, clonixeril, clonixin, clopamide, clopenthixol, cloperastine, deslorelin, desmeninol, desmethylmoramide, desmopressin, cloperidone, clopidogrel, clopidol, clopimozide, clopipazan, desocriptine, desogestrel, desmorphine, desonide, des clopirac, cloponone, cloprendol, cloprostenol, cloprothiaz Oximetasone, desoxycorticosterone, desvenlafaxine, detaj ole, cloquinate, cloquinozine, cloracetadol, cloranolol, clo mium, detanosal, deterenol, detirelix, detiviciclovir, detro razepate, cloraZepic acid, clorethane, chlorexolone, clorfen midine, detorubicin, detrothyronine, devapamil, devaZepide, Vinos, clorgiline, cloricromen, cloridarol, clorindanic acid, dexamethasone, dexamisole, dexbrompheniramine, dex clorindione, clormecaine, cloroperone, clorophene, cloro budesonide, dexchlorpheniramine, dexclamol, dexecadotril, qualone, clorotepine, clorprenaline, clorSulon, clortermine, dexefaroxan, dexetimide, dexetoZoline, dexfenfluramine, closantel, closiramine, clostebol, clothiapine, clothixamide, dexfosfoserine, dexibuprofen, deximafen, dexindoprofen, clotiazepam, cloticasone, clotioxone, clotixamide, clotrima dexivacaine, dexketoprofen, dexlofexidine, dexloxiglumide, Zole, clovoxamine, cloxacepride, cloxacillin, cloxazolam, dexmedetomidine, dexmethylphenidate, dexnafenodonee, cloxestradiol, cloximate, cloxotestosterone, cloxypendyl. dexniguldipine, dexnorgestrel, dexormaplatin, deXOXadrol, cloxyquin, clozapine, cobalamide, cocaine, codeine, dexpanthenol, dexpemedolac, dexpropranolol, dex.proxib codoxime, cofistatin, cogaZocine, colchicines, colestolone, utene, dexraZoxane, dexsecoverine, deXSotalol, dextilidine, colfenamate, colforsin, colfosceril, colimecycline, colterol, dextiopronin, dextofisopam, dextroamphetamine, dextro coluracetam, conessine, congaZone, conivaptan, conor femine, dextromethorphan, dextromoramide, dextrorphan, phone, cormethasone, corticorelin, cortisone, cortisuZol. dextrothyroxine, dexcerapimil, seZaguanine, dezinamide, cortivaZol, cortodoxone, cotinine, cotriptyline, coumaphos, dezocine, diacerein, diacetamate, diacetolol, diamfenetide, coumazolin, coumermycin, coumetarol, creatinine, creati diamocaine, diampromide, diamthiazole, diapamide, diar nolfosfate, cresotamide, cridanimod, crilvastin, crisinatol, barone, diathymosulfone, diatrizoate, diaveridine, diaz crobenetine, croconazole, cromakalim, cromitrile, cromogli epam, diaziquone, diazoxide, dibekacin, dibemethine, cate lisetil, cromolyn, crolom, cronidipine, cropropamide, dibenzepin, dibenzothiophene, dibrompropamidine, bibro crotamiton, crotetamide, crotoniazide, crotoxyfos, crufo msalan, dibrospidium, dibucaine, dibuprol, dibupyrone, mate, cuprimyxin, cuproXoline, cyacetacide, cyamemazine, dibusadol, dicarbine, dicarfen, dichloralphenaZone, cyanocobalamine, cyclacillin, cyclamate, cyclamic acid, dichloramine, dichlorisone, dichlormeZanone, dichlorophen, cyclandelate, cyclarbamate, cyclazocine, cyclazodone, dichlorphenarsine, dichloroxylenol, dichlorphenamide, cyclexanone, cyclindole, cycliramine, cyclizine, cyclobar dichlovos, diciferron, dicirenone, diclaZuril, diclofenac, bital, cyclobendazole, cyclobenzaprine, cyclobutoic acid, diclofenamide, diclofensine, diclofutrime, diclometide, cyclobutyrol, cyclocumarol, cyclofenil, cycloguanil, cyclo diclonixin, dicloralurea, dicloxacillin, diclolinium, dicum heximide, cyclomenol, cyclomethycaine, cyclopentamine, rol, dicyclomine, didanosine, didrovaltrate, dieldrin, dienes cyclopenthiazide, cyclopentolate, cyclophenazine, cyclo trol, dienogest, diethadione, diethylphthalate, diethylcar phosphamide, cyclopregnol, cyclopyrronium, cycloserine, bamazine, dietylpropion, diethylstilbestrol, cyclothiazide, cyclovalone, cycotiamine, cycrimine, dethylthambutene, dietyltoluamide, dietifen, difebarbamate, cyfluthrin, cyhalothrin, cyheptamide, cyheptropine, difemerine, difemetorex, difenamizole, difencloxazine, cynarine, cypenamine, cypermethrin, cypothrin, difenoximide, difenoxin, difetarsone, difeterol, diflomote cyprazepam, cyprenorphine, cyprodenate, cyproheptadine, can, diflorasone, difloxacin, difluanine, diflucortolone, diflu cyprolidol, cyproduinate, cyproterone, cyproximide, cyro midone, diflunisal, difluprednate, diftalone, digitalis, digi mazine, cysteamine, cysteine, cystine, cytarabine, cythi toxin, digoxin, dihexyverine, dihydralazine, olate, dabelotine, dabigatran, dabuZalgron, dacarbazine, dihydrocodeine, dihydroergotamine, dihydrostreptomycin, dacemazine, dacinostat, dacisteine, dacopafant, dactinomy dihydrotachysterol, diisobutylaminobenzoyloxypropyl theo cin, dacuronium, dagapamil, dagluril, dalbavancin, dal phylline, diisopromine, diisopropanolamine, diisopropy braminol, dalcotidine, daledalin, dalfopristin, dalteparin, lamine, dilaZep, dilevalol, dilimefone, diloxanide, diltiazem, daltroban, dalvastatin, dametralast, damotepine, danazol. dimabefylline, dimadectin, dimecamine, dimeclonium, daniquidone, danittracen, danofloxacin, danosteine, dan dimecrotic acid, dimefadane, dimefline, dimelazine, dimen US 2007/01 16729 A1 May 24, 2007 hydrinate, dimenoxadol, dimepheptanol, dimepranol, dime Zone, emitricitabine, emylcamate, enadoline, enalapril, pregnen, dimepropion, dimeproZan, dimeSna, dimesone, enalaprilat, enalkiren, enaZadrem, enbucrilate, encainide, dimetacrine, dimetamfetamine, dimethadione, dimethazan, enciprazine, enclomiphene, encyprate, endixaprine, endo dimethisoquin, dimethisterone, dimetholizine, dimetho mide, endralazine, endrysone, enecadin, enefexine, enest thizine, dimethoxanate, dimethylaminoethyl reserpilinate, ebol, enfenamic acid, enfluvirtide, englitaZone, eniclobrate, dimethylthambutene, dimethyltubocurarinium, enilconazole, eniloSpirone, eniluracil, eniporide, enisoprost, dimetipirium, dimetofrine, dimetridazole, diminaZene, enloplatin, enocitabine, enofelast, enolicam, enoxacin, dimiracetam, dimoxamine, dimoxaprost, dimoxyline, enoxamast, enoxaparin, enoXimone, enoXolone, enipipra dimpylate, dinaline, dinaZafone, diniprofylline, dinitolmide, Zole, empiroline, enprazepine, enprofylline, enpromate, dinoprost, dinoprostone, dinsed, diohippuric acid, dioSmin, enprostil, enramycin, enrasentan, enrofloxacin, ensacillin, diotyrosine, dioxadrol, dioxamate, dioxaphetyl butyrate, ensulizole, entacapone, entecavir, entSufon, enviomycin, dioxation, dioxethedrin, dioxifedrine, dioxybenaZone, enviradene, enviroxime, enZacamene, anZastaurin, epalr dioxyline, dipenine, diperodon, diphemanil, diphenadione, estat, epanolol, eperezolid, eperisone, epervudine, ephe diphenan, diphenchloxazine, diphenhydramine, diphenidol. drine, epicainide, epicillin, epicriptine, epiestriol, diphenoxylate, diphenylpiperidinomethyldioxolan, diphe epimestrol, epinastine, epinephrine, epinepheryl, epipropi nylpyraline, diphenoxazide, dipipanone, dipiproverine, dine, epirizole, apiroprim, epirubicin, epitetracycline, epi dipivefrin, diprafenone, diprenorphine, diprobutine, dipro thiazide, epitioStanol, eplerenone, elivanserin, epoprostenol, fene, diprogulic acid, diproleandomycin, diprofylline, dip epostane, eprazinone, eprinomectin, epristeride, eprobe roqualone, diproteverine, diprotrizoate, diproxadol, dipy mide, eprosartan, eprovafen, eproXindine, eproZinol, ridamole, dipyrithione, dipyrocetyl, dipyrone, diduafosol, epsipranel, epaloprost, eptapirone, eptaplatin, eptastigmine, dirithomycin, dirlotapide, disermolide, disquonium, disob eptazocin, eptifibatide, equillin, erbuloZole, erdosteine, utamide, Sidofenin, Sdisogluside, disopyramide, disoxaril. ergocalciferol, ergonovine, ergotamine, eritoran, erizepine, distigmine, disufenton, disulergine, disulfamide, disulfiram, erlotinib, ercainide, ersentilide, ertapenem, ertiprotafib, disupraZoole, ditazole, ditekiren, ditercalinium, dithiaanine, erythrity tetrnitrate, erythromycin, esafloxacin, esaprazole, ditiocade, ditiocarb, ditiomustane, ditolamide, ditophal, div esatenolol, escitalopram, esculamine, eseridine, esflurbipro abuterol, divalproex, divaplon, dixanthogen, dizatrifone, fen, esketamine, escarbazepine, esmolol, esomeprazole, eso dizcilpine, dobesilate, dobupride, dobutamide, dobutamine, narimod, esorubicin, esoxybutynin, espatropate, esproquin, docarpamine, docebenone, docetaxel, doconazole, doconex estazolam, estradiol, estramustine, estraZinol, estriol, estro ent, docosanol, docusate, dodeclonium, dodicin, dofamium, furate, estrone, estropipaten esupone, esZopclone, etaben dofeculidar, dolfetilide, dolasetron, doliracetam, domazoline, Zarone, etacepride, etafedrine, etafenone, etalocib, domiodol, domiphen, domipizone, domitroban, domopred etamestrol, etaminile, etamiphylline, etamocycline, etanida nate, domoxin, domperidone, donepezil, donetidine, doni Zole, etanterol, etaqualone, etarotene, etasuline, etazepine, triptan, dopamantine, dopamine, dopexamine, dopropidil, etazolate, etebenecid, eterobarb, etersalate, ethacridine, doqualast, dorampimod, doramectin, doranidazole, doras ethacrynic acid, ehtambutol, ethamivan, ethamsylate, ethav tine, Soreptide, doretinel, doripenem, dorZolamide. dosergo erine, ethenZameide, ethiazide, ethinamate, ethinyl estradiol. side, doSmalfate, dotarizine, dotefonium, dothiepin, doxa ethionamide, ethisterone, ethoheptazine, ethomoxane, etho curium, doxapram, doxaprost, doxazosin, doxefazepam, nam, ethopabate, ethopropazine, ethoSuximide, ethotoin, doxenitoin, doxepine, doxergocalciferol, doxibetasol, doxi ethoxazene, ethoxazorutoside, ethoXZolamide, ethybenz fluridine, doxofylline, doxorubicin, doxpicomine, doxycy tropine, ethyl biscoumacetate, ethyl carfluZepate, ethyl car cline, doxylamine, draflazine, dramedilol, draquinolo, drazi trizoate, ethyl dibunate, ethyl dirazepate, ethyl loflazepate, dox, dribendazolew, drimidene, drobuline, drocinonide, ethylestrenol, ethylhydrocupreine, ethylmethylthiambutene, droclidinium, drofenine, droloxifene, drometrizole, dromo ethylmorphine, ethylnorepinepherine, ethylstilbamine, eth stanolone, dronabinol, drinedarone, dropempine, droperidol. ylnerone, ethylnodil, ethypicone, etibendazole, eticlopride, droprenilamine, dropropizine, drospirenone, drotaverine, eticyclidine, etidocaine, etidronate, etidronic acid, etifelm drotebanol, droxacin, droXicainide, droxicam, droxidopa, ine, etifenin, etifoxine, etilamfetamine, etillefrine, eti droximavir, droxypropine, duaZomycin, dulofibrate, dulox levodopa, etinidine, etipirium, etiprendol, etiproston, etirac etine, duloZafone, dumorelin, dumetacin, duoperone, etam, etiroXate, etisazole, etisomicin, etisulergine, etizolam, dupracetam, dutasteride, dyclonine, dyhydrogestrone, etocarlide, etocrylene, etodolac, etodroxizine, etofamide, dymanthine, dyphylline, ebalZotan, ebastine, eberconazole, etofenamate, etofemproX, etofibrate, etofermin, etofuradine, ebiratide, ebrotidine, ebselen, ecabapide, ecabet, ecadotril, etofylline, etoglucid, eorolex, etolotifen, etoloxamine, eto ecalcidene, ecamsule, ecastolol. ecenofloxacin, midate, etomidoline, etomoxir, etomitaZene, etonogestrel, echothiophate, ecipramidil, eclanamine, eclaZolast, ecomus etoperidone, etoposide, etoprindole, etoprine, etoricoxib, tine, econazole, ecopipam, ecraprost, ectylurea, edaglita etorphine, etosalamide, etoxadrol, etoxeridine, etoZolin, Zone, edaravone, edatrexate, edelfosine, edetol, edifolone, etrabamine, etravirine, etretinate, etriciguat, etryptamine, edogestrone, edonentan, edotecarin, edotreotide, edoxudine, etymemazine, eucaine, eucalyptol, eugenol, euprocin, evan edratide, edronocaine, edrophonium, efaproxiral, efaroxan, damine, evernimicin, everolimus, evicromil, exalamide, efavirenz, efegatran, efepristin, efetozole, efletirizine, eflo exametazime, examorelin, exaprolol, exatecan, exemestane, rnithine, efloxate, eflucimibe, elfiumast, efonidipine, efroto exepanol, exifone, exiprofen, exisulind, eZetimibe, eZlopi mycin, eganoprost, eglumetad, egtazic acid, equalen, elac tant, fadolmidine, fadrozole, falecalcitriol, fallintolol, falli ridar, elantrine, elanzepine, elaarofiban, elbanizine, pamil, falnidamol, famciclovir, famirapinium, famotidine, eldacimibe, eletriptan, elfazepam, elgotipine, elinafide, elip famotine, fampiridine, famprofaZone, fampronil, fananserin, rodil, elisartan, ellagic acid, elliptinium, elmustine, elnad fanapanel, fandofloxacin, fandoSentan, fanetizole, fantofar ipine, elopiprazole, elsamitrucin, eltanolone, eltenac, elto one, fantridone, fargilitazar, fasidotril, fasiplon, fasoracetam, prazine, elucaine, elvucitabine, elZasonan, elziverine, faudil, fazadinium, fazarabine, febantel, febarbamate, febu emakalim, emapunil, embramine, embusartan, embutra prol, febuverine, febuxostat, feclemine, feclobuzone, fedot mide, emedastine, emepronium, emetime, emeglitate, emi ozine, fedrilate, felbamate, felbinac, felipyrine, felodipine, lium, emiteflur, emiverine, emodepside, emopamil, emorfa feloprentan, fely pressin, femoxetine, fenabutene, fenace US 2007/01 16729 A1 May 24, 2007

tinol, fenaclon, fenadiazole, fenaftic acid, femalamide, line, furalazine, furaltadone, furaprofen, furazabol, furazoli femalcomine, fenamifuril, fenamole, fenaperone, fenbenda done, furazolium, furbicillin, furcloprofen, furegrelate, fure Zole, fenbenicillin, fenbufen, fenbutreazate, fencamfamin, thidine, furfenorex, furidarone, furmethoxadone, fencibutirol, fenclexonium, fleclofenac, fenclonine, fenclo furnidipine, furobufen, furodazole, furofenac, furomazine, rac, fenclozic acid, fendiline, fendizoate, fendosal, fener furomine, furosemide, furostilbestrol, fursalan, fursul itrol, fenestrel, fenethazine, fenethylline, fenetradil, fenflu tiamine, furterene, furtrethonium, fusafungine, fusidate, mizole, fenfluramine, flenfluthrin, fengabine, fenharmane, fusidic acid, fuzlocillin, gabapentin, gabapexate, gaboxadol, fenimide, feniodium, fenipentol, fenirfibrate, fenisorex, gacyclidine, gadobenate, gadobutrol, gadocollectic acid, fenitrothion, fenleuton, fenmetozole, fenmetraminde, gadodiamine, gadofosveset, gadomelitol, gadopenamide, fenobam, fenocinol, fenocitimine, fenofibrate, fenoldopam, gadopentetate, gadoteric acid, gadoteridol, gadoverseta fenoprofen, fenoterol, fenoerine, fenoxazoline, fenoxedil, mide, gadoxetate, gadoxeticaicid, galamustine, galntamine, fenozolone, fenpentadiol, femperate, fenprpalone, fenpipra galarubicin, galasomite, galdansetron, gallamine triethio mide, fenpiprane, fempiverinium, fenprinast, fenproporex, dide, gallopamil, galocitabine, galosemide, galtifenin, gam fenprostalene, fenduiaone, fenretinide, fenspiride, fentanyl. fexine, gamolenic acid, gamaXolone, ganciclovir, ganefro fenthion, fentiazac, fenticlor, fenticonazolem, fentonium, mycin, ganglefene, gainstigmine, gantacurium, gantofiban, fenvalerate, fenyripol, fepentolic acid, fepitrizol, fepradinol, gapicomine, gapromidine, garenoxacin, gatifloxacin, gaves feprazone, fepromide, feprosidinine, ferpifosate, fesoterod tinel, geclosporin, gedocarnil, gefarnate, gefitinib, gemaZo ine, fetoxylate, fexicaine, fexinidazole, fexofenadine, feza cine, gemcabene, gemcadiol, gemcitabine, gemeprost, gen tione, fezolamine, fiacitabine, fialuridine, fibracillin, fidar fibtrozil, gemifloxacin, gemopatrilat, gentamicin, gepefrine, estat, fidexaban, fiduXosin, figopitant, filaminast, filenadol, gepirone, geroquinol, gestaclone, gestadienol, gestodene, filipin, finafloxacin, finasteride, fingolimod, fipamezole, gestonorone, gestrinone, geVotroline, gimatecan, gimeracil, fipexide, fipronil, firocoxib, flavamine, flavodic acid, fla giparmen, giracodazole, giractide, girisopam, gitaloxin, vodilol, flavoxate, flazalone, flecainide, flerobuterol, gitoformate, glafenine, glaspimod, glatiramer acetate. gle fleroxacin, flesinoxan, flestolol, fletazepam, flezelastine, fli manserin, glenvastatin, gliamilide, glibotnuride, glib banserin, flindokalner, flocalcitriol, floctafenine, flomoxef, utimine, glicaramide, glicetanide, gliclazide, glicondamine, floptopione, florantyrone, flordipine, floredil, florfenicol, glidaZamide, gliflumide, glimepiride, glipalamide, glipizide, florifenine, flosatidil, flosequinan, flosulide, flotrenizine, gliquidone, glisamuride, glisentide, glisindamine, glisola floverine, floxacillin, floxacrine, floxuridine, flucizine, flu mide, glisoxepide, gloxazone, gloXimonam, glucametacin, alamine, fluianisone, fluazacort, fluaZuron, flubanilate, glucosamine, gluronolactone, glucuronamide, glunicate, flubendazole, flubepride, flucarbril, flucetorex, flucindole, glyburide, glybuthiazole, glubuZole, gy copyrrolate, glycy flucinprazine, flucloronide, fluconazole, flucrylate, flucy lamide, glyhexamide, glymidine, glyoctamide, glyparamide, tosine, fludalanine, fludarabine, fludazonium, fludeoxyglu glypinamide, glyprothiazole, gly Sobuzole, goralatide, gos cose, fludiazepam, fluidorex, fludoxopone, fludrocortisone, erelin, gramicidin, granisetron, grepafloxacin, griseofulvin, flufenamic acid, flufenisal, flufosal, flufylline, flugestone, guabenXan, guacetisal, guaifecainol, guaiactamine, guaiap fluindarol, fluindione, flumazenil, flimecinol, flumedroxone, ate, guaietolin, guaifenesin, guaimeSal, guaisteine, guaith flumequine, flumeridone, flumethasone, flumethiazole, flu yline, guanabenz, guanacline, guanadrel, guanaZodine, metramide, flumexadol, flumeZapine, fluminorex, flumizole, guanclofine, guancydine, guanethidine, guanfacine, flumoxonide, flunamine, flunarizine, flunidazole, guanisoquin, guanoclor, guanoctine, guanoxabenz, guan flunisolide, flunitrazepam, flunixin, flunoprost, flunoxapro oxan, guanoxyfen, gusperimus, halazepam, halazone, halci fen, fluocinolone, fluocinonide, fluocortin butyl, fluocor nonide, halethazole, halobetasol, halocortolone, halofan tolone, fluorescein, fluoresone, fluorodopa, fluo trine, halofenate, halofuginone, halometasone, halonamine, rometholone, fluorosalan, fluorouracil, fluotracen, halopemide, halopenium, haloperidol, halopredone, halo fluoxetine, fluoxymesterone, fluparoxan, flupentiXol, flu progesterone, haloprogin, haloxazolam, haloxon, halo peramide, fluperlapine, fluperolone, flupheazine, flupi qionol, hamycin, hedaquinium, heliomycin, hepronicate, mazine, flupirtine, flupranone, fluprazine, fluprednidene, heptabarbital, heptaverine, heptolamide, hepzidine, heroin, fluprednisolone, fluprofen, fluprofylline, fluproduaZone, flu hetacillin, hetaflur, heteronium, hexachlorophene, hexacy prostenol, fluguaZone, fluradoline, flurandrenolide, flurantel, clonate, hexacyprone, hexadiline, hexafluorenium, hexam flurazepam, flurbiprofen, fluretofen, flurithromycin, fluroc ethonium, hexaminolevulinate, hexapradol, hexaprofen, itabine, flurofamide, flurogestone, flusoxolol, fluspiperone, hexapropymate, hexasonium, hexazole, hexedine, hexestrol, fluspirilene, flutamide, flutazolam, flutemazepam, flutiazin, hexetidine, hexobarbital, hexobendine, hexocyclium, hexo fluticasone, flutizenol, flutomidate, flutonidine, fluto prenaline, hexopyrronium, heylcaine, histamine, histapyrro prazepam, flutrimazole, flutroline, flutropium, fluvastatin, dine, histidine, homarylamine, homatropine, homidium, fluvoxamine, fluzinamide, fluZoperine, fodipir, folic acid, homochlorcyclizine, homofenazine, homopipramol, homo fomepizole, fomidacillin, fominoben, fomiversen, salate, homprenorphine, hopantenic acid, hoquizil, hycan fomocaine, fonazine, fondaparinux, fopiirtoline, forasartan, thone, hydracarbazine, hydralazine, hydragaphen, forfenimex, formebolone, formestane, formetorex, formini hydrobentizide, hydrochlorothiazide, hydrocodone, hydro trazole, formocortal, formoterol, forodesine, foropafant, fos cortisone, hydroflumethiazide, hydromadinone, hydromor amprenavir, fosarilate, fosazepam, foSenazide, fosflucona phinol, hydromorphone, hydroquinone, hydroxyindasate, Zole, foSfocreatinine, fosfomycin, foSfonet, fosfosal, hydroxyindasol, hydroxocobalamin, hydroxyamphetamine, fosfructose, fosinopril, fosinoprilat, foSmenic acid, foSmi hydroxychloroquin, hydroxydione, hydroxypethidine, domycin, fosopamine, fosphenyloin, fospirate, fosquidone, hydroxyphenamate, hydroxyprocaine, hydroxyprogester fostedil, foSrtriecin, fosveset, fotemustine, fortrenamine, one, hydroxypyridine tartrate, hydroxystenozole, hydrox fozivudine, frabuprofen, fradafiban, frakefamide, framyce yStilbamidine, hydroxytetracaine, hydroxyzine, hymec tin, frentizole, freselestat, fronepidil, fropenem, froVatriptan, romone, hyoscyamine, ibafloxacin, ibandronate, ibazocine, froxiprost, ftaxilide, ftivazide, formetazine, forpropazine, ibopamine, ibrolipim, ibrotamide, ibudalast, ibufenac, ibu fubrogonium, fudosteine, fuladectin, fulvestrant, fumagillin, profen, ibuproxam, ibutamoren, ibuterol, ibutilide, ibuver fumoxicillin, fungimycin, fuprazole, furacrinic acid, furafyl ine, icaridin, icatibant, iclaprim, icazepam, icodulinium, US 2007/01 16729 A1 May 24, 2007 10 icofungipen, ifometaSone, icopezil, icosapent, icospiramide, lamotrigine, lamitidine, lanatoside, landiolol, lanepitant, icotidine, icrocaptide, idarubicin, idaverine, idazoxan, ide lanicemine, laniquidar, lanoconazole, lanperisone, lanpros benone, idenast, idoxifene, idoxuridine, idralfidine, idra ton, lanreotide, lanSoprazole, lapatinib, lapisteride, laprafyl mantone, idraparinux, idrapril, idremcinal, idrociliamide, line, lapyrium, lacquinimod, lasalocid, lasinavir, lasofox idronoxil, idropranolol, iferanserin, ifetroban, ifosfamide, ifene, latanoprost, laudexium, laurcetium, laurocapram, ifoxetine, iganidipine, igmesine, iguratimod, ilaprazole, ila lauroguadine, laurolinium, lauryl isoquinolinium, lavolti treotide, ilepcimide, iliparcil, ilmofosine, illoomastat, dine, lazabemide, lecimibide, ledazerol, ledoxantrone, lefe ilonidap, illoperidone, imafen, imanixil, imatinib, imaZodan, tamine, leflunomide, lefradafiban, leiopyrrole, lemidosul, imcarbofos, imiclopazine, imidafenacin, imidapril, imidap lemidipine, leminoprazole, lemoxinol, lemuteporfin, lanali rilat, imidocarb, imidoline, imidurea, imiglitazar, imiloxan, domine, lenampicillin, lenapenem, leniquisin, leuperone, iminophenimide, imipenem, imipramine, imipraminoxide, leptacline, lercanidipine, lergotrile, lerisetron, lesoptiron, imiquimod, imirestat, imitrodast, imolamine, imoxiterol, lestaurtinib, leteprinim, leteprinim, letimide, letosteine, impacarzine, implitapide, impromidine, improSulfan, imu letraZuril, letrozole, leucinocaine, leucocianidol, leucovorin, racetam, inamirone, inaperisone, incadronic acid, inda leurubicin, levalbuterol, levallorphan, levamfetamine, caterol, indacrinone, indalpine, indanazoline, indanidine, levamisole, levcromakalim, levcycloserine, levdobutamine, indanorex, indapamide, indatraline, indecainide, indelox levemoamil, levetiracetam, levisoprenaline, levlofexidine, azine, indenolol, indibulin, indigotindisulfonate, indinavir, levmetamfetamine, levobetaxolol, levobunolol, levobupi indiplon, indisetron, indobufen, indocate, indocyanine acaine, levocabastine, levocamitine, levodopa, levodro green, indolapril, indolidan, indomethacin, indopanolol. propizine, levofacetoperane, levofenfluramine, levofloxacin, indopine, indoprofen, indoramin, indorenate, indoxole, levofluraltadone, levoleucovorin, levomenol, levomepro indriline, inecalcitol, ingliforib, inicarone, inocterone mazine, levomethadone, levomethadyl acetate, levometho acetate, inogatran, inosine, inositol, improquoone, intopli rphan, levometiomeprazine, levomoprolol, levomoramide, cine, intrazole, intriptyline, inulin, iobenguane, iobenzamic levonantradol, levonordefrin, levonorgestrel, levophenacyl acid, iobitridol, iobutoic acid, icanlidic acid, iocarmic acid, morphan, levopropoxyphene, levopropylcilline, levopro iocetamic acid, iodamine, iodipamide, iodixanol, iodoan puylhexedrine, levoprotiline, levorin, levormeloxifene, tipyrine, iodocholesterol, iodohippurate, iodoquinol, iodot levorphanol, levosalbutamol, levosemotiadil, levosimendan, hiouracil, idoxamic acid, iofetamine, ioflupane, iofratol, levosulpiride, levothyroxine, levotofisopam, levoxadrol, ioglicic acid, ioglucol, ioglunide, ioglycamic acid, iogulaa lexipafant, lexithromycin, lexofenac, liarozole, libecillide, mide, iohexol, iolidonic acid, iolixanic acid, iolopride, ioma libenzapril, licarbazepine, licofelone, licostinel, lidadronic Zenil, iomeglamic acid, iomeprol, iomethin, iometopane, acid, lidamine, lidanserin, lidocaine, lidoferin, lidorestat, iomorinic acid, iopamidol, iopanoic acid, iopentol, lifariaine, lifibrate, lifibrol, lilopristone, limaprost, limazocic iophendylate, iophenoxic acid, iopromide, iopronic acid, acid, linarotene, lincomycin, lindane, linetastine, lineZolid, iopydol, iopydone, iosarcol, isofenamic acid, io.seric acid, linogliride, linopirdine, linotroban, lisinidomine, lintitript, iosimenol, iosimide, ioSulamide, ioSumetic acid, iotasul, lintopride, liothyronine, lipoic acid, liraglutide, liranaftate, ioteric acid, iothalamate, iothalamic acid, iotranic acid, lirequinil, lirexapride, lirimilast, liroldine, lisadimate, lisi iotriside, iotrizoic acid, iotrolan, iotroxic acid, iotyrosine, nopril, lisofylline, lisuride, litomeglovir, litoxetine, litracen, iovesol, ioxabrolic acid, ioxaglic acid, ioxilan, ioxitalamic lividomycin, lixazinone, lixivaptan, lobapolatin, lobeline, acid, ioxotrizoic acid, ioZomic acid, ipamorelin, ipazilide, lobendazole, lobenzarit, lobucavir, lobuprofen, locicor ipenoxazone, ipexidine, ipidacrine, ipodate, iprgratine, ipra tolone, lodaxaprine, lodaZecar, lodelaben, lodenosine, midil, ipratropium, ipravacaine, iprazochrome, ipriflavone, Iodinixil, lodiperone, Iodoxamide, lofemizole, lofendazam, iprindole, ipocinidine, iproclozide, iprocrodol, iprofenin, lofentanil, lofepramine, lofexidine, loflucarban, lombazole, iproheptine, iproniazide, ipronidazole, iproplatin, ipro lomefloxacin, lomeguarib, lomerizine, lometraline, lometr tiazem, iproxamine, iprozilamine, ipsalazide, ipsapirone, exol, lomevactone, lomifylline, lomofungin, lomustine, iquindamine, iralukast, irampanel, irbesartan, irindalone, lonafarnib, lonapalene, lonaprofen, lonazolac, lonidamine, irinotecan, irloxacin, irofulven, irolapride, iroXanadine, loperamide, lopinavir, lopirazepam, lopobutan, loprazolam, irsogladine, irtemazole, isalidole, isalsteine, isamfaZone, loracarbef, lorajmine, lorapride, lorazepam, lorbamate, isamoltan, isamoxole, isatoribine, isaxonine, isbogrel, isbu lorcainide, lorcinadol, loreclezole, lorglumide, fylline, ispamicin, isoamilinile, isobromindione, isobucaine, lormetazepam, lornoxicam, lopiprazole, lortalamine, isobutamben, isocarboxazid, isoconazole, isocromil, isoet lorZafone, losartan, losigamone, losindole, loSmiprofen, harine, isoflupredone, isoflurophate, isomazole, isomerol, losoxantrone, losulazine, loteprednol, lotrafiban, lotrifen, isometamidium, isomethadone, isometheptene, isomolpan, lotucaine, lovastatin, loviride, loxanast, loxapine, loxiglu isoamylamine, isoniazid, isonixin, isoprazole, isopred mide, loxoprofen, loxoribine, lozilurea, lubazodone, lubelu nidene, isoprofen, isopropamide, isopropicillin, isoproter Zole, lubiprostone, lucanthone, lucartamide, lucimycin, enol, isoSrbide, isospaglumic acid, isosulfan blue, isosul lufenuron, lufironil, lufuradom, luliconazole, lumiracoxib, pride, isothipendyl, isotiquimide, isotretinoin, isoxaprolol. lupitidine, luprostiol, lurasidone, lurosetron, lurototecan, isoxepac, isoxicam, isoxSuprine, isradipine, israpafant, istr lusaperidone, luxabendazole, lydimycin, lymecycline, defylline, itameline, itanoXone, itasetron, itaZigrel, itopride, lynestrenol, lypressin, mabuprofen, mabuterol, madurami itraconazole, itriglumide, itrocainide, itrocinonide, iturelix, cin, mafenide, mafoprazine, mafosfamide, malathion, ivbradine, ivarimod, ivermectin, ivoqualine, ixabepilone, maleylsulfathiazole, malotilate, mangafodipir, manidipine, iZonsteride, josamycin, kainic acid, kalafungin, kanamycin, manifaxine, mannomustine, manoZodil, mantabegron, mapi kebuZone, keracyanin, ketamine, ketanserin, ketazocine, nastine, maprotiline, maraviroc, marbofloxacin, maribavir, ketazolam, kethoxal, ketipramine, ketobemidone, ketocaine, maridomycin, marimastat, mariptiline, maropitant, maroX ketocainol, ketoconazole, ketoprofen, ketorfanol, ketorolac, epin, masoprocol, maxacalcitol, maytansine, mazapertine, ketotifen, ketotrexate, khellin, khelloSide, kitasamycin, labe maZaticol, mazindol, maZipredone, mazokalim, mebana talol, labradimil, lachesine, lacidipine, lacosamide, lactal Zine, mebendazole, menbenoside, mebeverine, mebeZo fate, lactilol, lactulose, ladirubicin, ladostigil, laflunimus, nium, mebhydrolin, mebiquine, mebolazine, mebrofenin, lafutine, laidlomycin propionate, lamifiban, lamivudine, mebutamate, mebutizide, mecamylamine, mecarbinate, US 2007/01 16729 A1 May 24, 2007

mecetronium, meciadanil, mecinarone, meclinertant, metrazifone, metrenperone, metribolone, metrifonate, met meclizine, meclocycline, meclofenamaic acid, meclofenox rifudil, metrizamide, metrizoate, metronidiazole, meture ate, meclonazepam, mecloqualone, meclorisone dibutyrate, depa, metyrapone, metyrosine, mevastatin, mexafylline, mecloxamine, mecobalamin, medazepam, medazomide, mexazolam, mexenone, mexiletine, mexiprosil, mexopro medetomidine, medibazine, medifoxamine, medorinone, fen, meXrenoate, meZacopride, meZepine, meZilamine, medorubicin, medrogestrone, medronic acid, medroxalol, meZlocillin, miaanserin, mibefradil, mibolerone, miboplatin, medroxyprogesterone acetate, medrylamine, medrysone, micafungin, miconazole, micronomicin, midaflur, midafotel, mefeclorazine, mefenamic acid, mefenidil, mefenidramium, midaglizole, midamaline, midaxifylline, midazogrel, mida mefenorex, mefeserpine, mefexamide, mefloquine, mefru Zolam, midecamycin, midestein, midodrine, midostaurin, side, megalomycin, megestrol, megace, meglitinide, mifentidine, mifepristone, mifobate, miglitol, miglustat, meglucycline, meglumine, meglutol, meladrizine, melagat mikamycin, milacainide, millacemide, milameline, ran, melarsomine, melarsonyl, melarsoprol, meldonium, milataxel, milenperone, milfasartan, millipertine, miloxacin, melengestrol acetate, meletimide, melevodopa, melinamide, milrinone, miltefosine, milverine, mimbane, minalrestat, melitracen, melizame, meloxicam, melperone, melphalan, minamestane, minaprine, minaXolone, mindodilol, mindop melduinast, meluadrine, mamantine, memotine, menabitan, erone, minepentate, minocromil, minocycline, minodronic menadiol, menadione, menadoxime, menatetrenone, menb acid, minopafant, minoxidil, mioflaazine, mipitroban, utone, menfegol, menglytate, menitrazepam, menoctone, mipragoside, miproxifene, mirfentanil, mirincamycin, mir menogaril, menobentine, mepazine, mepenZolate, meperi ipirium, miriplatin, mirisetron, miristalkonium, miroprofen, dine, mephenesin, mephenoxalone, mephentermine, mephe mirosamicin, mirostipen, mirtazapine, misonidazole, miso nyloin, mephobarbital, mebaral, mepindolol, mepiperpheni prostol, mitemcinal, mitiglinide, mitindomine, mitobronitol, dol, mepiprazole, mepiroXol, mepitioStane, mepivacaine, mitocarcin, mitoclomine, mitocromin, mitoflaxone, mitogil mepixanox, mepramidil, meprednisone, meprobamate, lin, mitoguaZone, mitolactol, mitomalcin, mitomycin, meprochol, meproscillarin, meprotixol, meprylcaine, mitonafide, mitopodozide, mitoquidone, mitosper, mitolane, meptazinol, medulidox, meduinol, meduitamium, meduita mitotenamine, mitoxantrone, mitoZolomide, mitradipide, Zine, meradimqate, menthyl anthranilate, merafloxacin, mivacurium, mivobulin, mivotilate, mixidine, mizolastine, meralein, meralluride, merbaphen, merbromin, mercaptom mizoribine, mobecarb, mobenzoxamine, mocimycin, erin, mercaptopurine, mercuderamide, mercufenol, mercu mociprazine, moclonemide, moctamide, modafinil, moda matilin, mergocriptine, meribendan, merimepodib, mero line, modecainide, modipafant, moexipril, moexiprilat, penem, mersalyl, mertialide, mesabolone, mesalamine, mofarotene, mofebtaZone, mofegiline, mofeZolac, moflover meseclaZone, mesocarb, mesoridazine, mesipiperone, ine, mofoxine, mofuisteine, molfarnate, molinaZone, molin mespirenone, mestanolone, mesterolone, mestranol, mesu done, molracetam, molsidomine, mometasone, monalaZone, dipine, mesulergine, mesulfamide, mesulfen, meSuprine, monatepil, monesin, monobenzone, monoctanoin, metabromsalan, metbutethamine, metabutoxycaine, metac monometacrine, monophosphothiamine, monoxerutin, mon etamol, metaclazepam, metacresol, metaglycodol, meta telukast, monterelin, moperone, mopidamol, mopidralazine, hexamide, metalkonium, metalol, metamelfalan, metamfa moprolol, moquizone, morantel, moraZone, morclofone, Zone, metamfenpramone, metampicillin, metanixin, morforex, moricizine, morinamide, momiflumate, moro metapramine, metaproterenol, metaraminol, metaxalone, cromen, moroxydine, morpheridine, morphine, morSuxim metaZamide, metazide, matazocine, metbufen, meteneprost, ide, mosapramine, mosapride, motapizone, motexafin, metergoline, metergotamine, metescufylline, metesculetol, motrazepam, motrtinide, moveltipril, moxadolen, moxalac metesind, metethoheptazine, metformin, methacholine, tam, moxaprindine, moxastine, moXaverine, moxazocine, methacycline, methadone, methadyl acetate, methallenestril, moxestrol, moxicoumone, moxidectin, moxifloxacin, moxi methallibure, methalthiazide, methamphetamine, meth lubant, moxipraquine, moxirapine, moxisylate, moXnida andriol, methandrostenolone, methaniazide, methantheline, Zole, moxonidine, moZavaptan, moZenavir, mubritnib, methaphenilene, methapyrilene, methaqualone, metharbital, mupirocin, murabutide, muraglitazar, mureletecan, methastyridone, methazolamide, methdilazine, meth murocainide, muZolimine, mycophenolic acid, my fadol, enamine, methenolone, metheptazine, methestrol, meth myrophine, myrtecaine, nabaZenil, nabilone, nabitan, nab etoin, methikcillin, methimazole, methiodal, methiomepra octate, nabumetone, nacartocin, nadide, nadiofloxacin, nad Zine, methionine, methisaZone, methitural, methixene, olol, nadoxolol, nafagrel, nafamo.stat, nafarelin, nafazatrom, methocarbamol, methocidin, methohexital, methopholone, nafcaproic acid, nafcillin, nafenodone, nafenopin, nafetolol. methoprene, methoserpidine, methotrexate, methotrimepra nafimidone, nafiverine, naflocort, nafomine, nafoxadol, Zine, methoxamine, methoXSalen, methoxyphedrine, meth nafoxidine, nafronyl, naftalofos, naftaZone, naftifine, nafto oxyphenamine, methoxypromazine, methScopolamine, pidil, naftoxate, naftypamide, naglivan, nalbuphine, nal methSuximide, methyclothiazide, methyl aminolevulinate, furafine, nalidixic acid, nalmefene, nalmexone, nalorphine, methyl palmoxirate, methyl salicylate, methylatropine, naloxone, naltrexone, naminidil, naminterol, namirotene, methylbenactyzium, methylbenzethonium, methylcromone, namoxyrate, nanafrocin, nandrolone, nanterinone, nantra methyldesorphine, methyldihydromorphine, methyldopa, dol, napactadine, napamezole, naphazaoline, naphthonone, methylene blie, methylephedrine, methylergometrine, meth napirimus, napitane, naproxime, naproxen, naproxol, nap ylergonovine, methyllparaben, methylphenidate, methyl sagatran, naranol, narasin, naratriptan, nardetoterol, naro prednisolone, methyltestosterone, methylthiouracil, meth parcil, natamycin, nateglinide, navuridine, naxagolide, nax ynodiol, methyprylon, methysergide, metiamide, metiapine, aprosteine, naxifylline, nealbarbital, nebantan, nebidrazine, metiazinic acid, metibride, meticrane, metildigoxin, metin nebivolol, neboglamine, nebracetam, nebramycin, necopi dizate, metioprim, metioxate, metipirox, metiprenaline, dem, nedaplatin, nedocromil, nefazodone, nefiracetam, metitepine, metizoline, metkephamid, metochalcone, meto neflumozide, nefopam, nelarabine, neldaZosin, neleZaprine, cinium, metoclopramide, metocurine, metofenazate, nelfinavir, meltenexine, nelZarabine, nemadectin, nemaZo metogest, metolaZone, metomidate, metopimazine, meto line, nemifitide, nemonapride, memorubicin, neocinchophen, pon, metoprine, metoprolol, metoquizine, metoserpate, neomycin, neostigmine, nepadutant, nepafenac, nepapra metostilenol, metoxepin, metrafazoline, metralindole, Zole, nepicastat, nepinalone, nequinate, neramexane, US 2007/01 16729 A1 May 24, 2007 12 neraminol, nerbacadol, neridronic acid, nerisopam, nesapi oxaflumazine, oxagrelate, oxalinast, oxaliplatin, oXamarin, dil, nesiritide, nesosteine, nestifylline, neticonazole, netilmi Oxametacin, oxamisole, oxaminiquinem oxanamide, oxan cin, netivudine, netobimin, netoglitaZone, netupitant, neu drolone, oxantel, oxapadol, oxapium, Oxaprazine, Oxapro tramycin, neviparine, nexeridine, nexopamil, niacin, tiline, oxaprozin, oXcarbazole, Oxatomide, oxazafone, niacinamide, nialamide, niaprazine, nibroxane, nicafenine, oxazepam, oxazidone, oxazolam, oxazorone, oXcarba nicainoprol, nicametane, nicanartine, nicaraven, nicarbazin, Zepine, oxdralazine, oxeclosporin, oxedrine, Oxeglitazar, nicardipine, nicergoline, niceritol, niceverine, niclofolan, oXeladin, oxendolone, oxepinac, oxetacillin, oxethazine, niclosamide, nicoboxil, nicoclonate, nicocodine, nicocor oxetorone, Oxfendazole, Oxfenicine, oxibendazole, Oxibe tonide, nicocidodine, nicoduozide, nicofibrate, nicofura taine, oxiconizole, oxidapamine, oxidronic acid, Oxfentorex, nose, nifurate, nicogrelate, nicomol, nicomorphine, nicop oxifungin, oxigluttione, OXilofrine, oxilorphan, OXimonam, holine, nicoracetam, nicorandil, nicothiazone, nicotredole, oXindanac, oxiniacic acid, Oxperomide, oxiracetam, oxira nicoXamat, nictiazem, nictindole, nidroxy Zone, nifedipine, mide, oxisopred. Oxisuran, oxitefonium, oxitriptan, oxitrip nifekalant, nifemalol, nifenaZone, niflumic acid, nifungin, tyline, OXtriponium, OXmetidine, oxodipine, oxogestone, nifiradene, nifuraldezone, nifuralide, nifuratel, nifuratrone, oXolamine, OXolinic acid, oXomermazine, oXonazine, nifurdazil, nifurethazone, nifurfoline, nifurimide, nifuri oXophenarsine, oxoprostol, oxpheneridine, Oxprenoate, Zone, nifurmazole, nifurmerone, nifuroquine, nifuroxazide, oXprenolol, oxtriphylline, oxbenzone, oxybutynin, oxychlo nifuroxime, nifurpipone, nifurpirinol, nifirprazine, rosene, oxycinchophen, oxyclipine, oxyclozanide, oxyc nifurquinazol, nifursemizone, nifursol, nifurthiazole, nifur odone, oxydipentonium, oxyfedrine, oxymesterone, timox, nifurtoinol, nifurvidine, nifurzide, nigludipine, nihy oxymetazoline, oxymethalone, oxymorphone, oxypendyl. draZone, nikethamide, nileprost, nilprazole, niludipine, oxypertine, oxyphenbutaZone, oxyphencyclimine, nilutamide, nilvadipine, nimaZone, nimeSulide, oxyphenisatin, oxyphenonium, oxypurinol, oxypurronium, nimetazepam, nimidane, nimodipine, nimorazole, nimus oxyquinoline, Oxyridazine, oxysonium, oxytetracycline, tane, neometacin, niperotidine, nipradillol, niprofaZone, oxytocin, OZagrel, OZagamicin, oZolindone, paclitaxel, nitavoline, nirdazole, nisbuterol, nisobamate, nisoldipine, pacrindolol, pactimibe, padimate A, padimate Q, pafenolol. nisoxetine, nisterime, nitarSone, nitaZoxanide, nitecapone, pagoclone, paldimycin, palinavir, paliperidone, palmidrol, nithiamide, nitisinone, nitracrine, nitrafudan, nitralamine, palmoxirate, palonidipine, palonosertron, palosuran, pam nitramisole, nitraduaZone, nitrazepam, nitrefazole, nitren abron, pamaqueside, pamaquin, pamicogrel, pamidronic dipine, nitrocefin, nitroclofene, nitrocycline, nitrodan, nitro acid, panadiplon, panamesine, pancopride, pancuronium, furantoin, nitrofuraZone, nitromersol, nitromide, panipenem, panomifene, pantenicate, pantethine, panthenol, nitromifene, nitroscanate, nitrovin, nitroXinil, nitroxoline, pantoprazole, panuramine, papverine, papveroline, nivaZol. nivimedone, nizatidine, nizofenone, noberastine, parachlorphenol, paraflutizide, paramethadione, parametha nocloprost, nocodazole, nofecainide, nogalamycin, nolatr Sone acetate, paranitrosulfathiazole, paranyline, parapen exed, nolinium, nolomirole, nolpitantium, nomegestrol, Zolate, parapropamol, pararosaniline, paraxaZone, parbenda nomelidine, nomifensine, nonabine, nonaperone, nonapy Zole, parcetasal, parconazole, parecoxib, pareptide, rimine, nonathymulin, nonivamide, noracymethadol, norbo parethoxycaine, pargeverine, pargolol, pargyline, paricalci lethone, norbudroine, norcholestenol, norclostebol, norco tol, paridocaine, parodilol, paromomycin, paroxetine, par deine, nordazepam, nordefrin, nordinone, norelgestromin, oxypropione, parsalmide, particin, parvaquone, pasiniazid, norepinepherine, norethandrolone, noethindrone, nor pasireotide, patamostat, patupilone, paulomycin, paxamate, ethynodrel, noreximide, norfenefrine, norfloxacin, norgest paZelliptine, paZinaclone, paZOxide, paZufloxacin, pecilocin, erone, norgestimate, norgestomet, norgestrel, norg pecocycline, pefloXocin, pelanserin, peldesine, peliomycin, estrieneone, norletimol, norlevorphenol, normethadone, pelitinib. pelitrexol, pelretin, pelrinone, pelubiprofen, normorphine, norpipanone, nortetrazepam, nortopixantrone, pemedolac, pemerid, pemetrexed, pemirolast, pemoline, nortriptyline, norvinisterone, noSantine, noscapine, nosihep penamecillin, penbutolol, penciclovir, pendecamine, pen tide, novobiocin, noxiptiline, noxytiolin, nuclomedone, detide, penfluridol, penflutizide, pengitoxin, penicillamine, nuclotixene, nulfenoXole, nupafant, nuvenZepine, nylestriol, penicillin G, penicillin V, penimepicycline, penimocycline, nylidrin, nystatin, obidoxime, ocaperidone, ocfentanil, ocilt penirolol, penmesterol, penoctonium, penprostene, pent ide, ocinaplon, octacaine, octafonium, octamoxin, octapinol, abamate, pentacynium, pentfluranol, pentagastrin, pentag octatine, octaverine, octaZamide, octenidine, Octicizer, estrone, pentalamide, pentamethonium, pentamidine, penta octimibate, Octinoxate, octisalate, octocrylene, octodrine, morphone, pentamoxane, pentamustine, pentapiperide, octopamine, octotiamine, octreotide, octriptyline, octriazole, pentapiperium, pentaquine, pentazocine, pentetic acid, pen odalprofen, odapipam, odiparcil, ofloxacin, oftomine, oftas treotide, penthienate, penthrichloral, pentiapine, pentifyl ceine, oglu fanide, olaflur, olamufloxacin, olanexidine, olan line, pentigetide, pentisomicin, pentisomeide, pentizidone, Zapine, olaquindox, olcegepant, oleandomycin, oletimol, pentobarbital, pentolinium, pentolonium, pentomone, pen olmesartan, olopatadine, olpadronic acid, olpimedone, topril, pentorex, pentosalen, pentostatin, pentoxifylline, pen olprinone, olradipine, olsalazine, oltipraz, olvanil, omaci toxyverine, pentrinitrol, pentylenetetraZol, peplomycin, pep clovir, omapartrilat, omeprazole, omidoline, omigapil. statin, peraclopone, peradoxime, perafensine, peralopride, omiloxetine, omoconazole, omonasteine, onapristone, peramivir, peraquisin, perastine, peratizole, perazine, perbu ondansetron, ontazolast, ontianil, opanixil, opaviraline, fylline, perfomedil, perfosfamide, pegolide, perhexiline, opiniazide, opipramol, opratonium, oraZamide, oraZipone, periciazine, perifosine, perimetazine, perindopril, perindop orbofiban, orbutopril, orconazole, orientiparcin, oritavancin, rilat, perisoxal, perlapine, permethrin, peroSpirone, per orlistat, ormaplatin, ormeloxifene, ormetoprin, ornidazole, phenazine, persilic acid, perZinfotel, petrichloral, peXantel, ornipreessin, ornithine, ornoprostil, orotic acid, orotirelin, phanquone, phenacaine, phenacemide, phenacetin, phenac orpanoxin, orphenadrine, ortataxel, orteteamine, osanetant, tropinium, phenadoxone, phenaglycodol, phenamaZoline, OSaterone, oseltamivir, OSemoZotan, osmadizone, phenampromide, phenaphthazine, phenarsone, phenazocine, ospennifene, ostreogrycin, oSutidine, otamixaban, otenZe phenaZopyridine, phenbutaZone, phencarbamide, phencyc pad, oteracil, otilonium, otimerate, ouabain, Oxabolon, lidine, phendimetrazine, phenelZine, pheneridine, phenethi oXabrexine, oxaceprol, oxacillin, oxadimedine, oxafloZane, cillin, pheneturide, phenylglutarimide, phenicarbazide, US 2007/01 16729 A1 May 24, 2007 phenindamine, phenindione, pheniprazine, pheniramine, procainamide, procaine, procarbazine, procaterol, prochlor phenisonone, phenmetrazine, phenobarbital, phenobutiodil, perazine, procinolol, procinonide, proclonol, procromil, pro phenomorphan, phenothiazine, phenothrin, phenoxyben cyclidine, procymate, prodeconium, prodilidine, prodipine, Zamine, phenoxypropazine, phenprobamate, phenprocou prodolic acid, profadol, profexalone, proflavine, mon, phenpromethamine, phensuXimide, phentermine, proflazepam, progabide, progesterone, proglumetacin, pro phentolamine, phenyl aminosalicylic acid, phenylalanine, glumide, proheptazine, proligestone, praline, prolintane, phenylbutaZone, phenylephrine, phenylpropanolamine, phe prolonium, promazine, promegestone, promestriene, nylthiolone, phenyltoloxamine, pheny racillin, phenyrami promethazine, promolate, promoxolane, prontalol, propac dol, phenyloin, pnetharbital, pholcodine, pholedrine, etamol, propafenone, propagermanium, propamidine, pro phoxim, phthalofyne, phthylsulfacetamide, phthalylsul panidid, propanocaine, propantheline, proparacaine, pro famethiazole, phthalylsulfathiazole, physostigmine. Phytic patyl nitrate, propazolamide, propenidazole, acid, phytonadione, pibaxizine, pibecarb, piberaline, pibos proprintofylline, propenZolate, properidine, propetamide, erod, pibroZelesin, pibutidien, picafibrate, picartamide, propetamfos, propetandrol, propicillin, propikacin, propin picenadol, picilorex, piclaimilast, piclonidine, piclopastine, etidine, propiomazine, propiocaine, propiram, propisergide, picloxydine, picobenzide, picodralazine, picolamine, propiverine, propizepine, propofol, propoxate, propoXur, piconol, picoperine, picoplatin, picoprazole, picotamide, propoxycaine, propoxyphene, propranolol, propyl docetri picotrin, picumast, picumeterol, pidobenzone, pidolaceta Zoate, propyl gallate, propylhexedrine, propyliodone, pro mol, pidolicaica, pidotimod, pifarnine, pifinate, pifexole, pylthiouracil, propyperone, propyphenaZone, propyro piflutiXol, piketoprofen, pildralazine, pilocarpine, pilsicain mazine, produaZone, produinolate, prorenoate, proroXan, ide, pimagedine, pimeclone, pimecrolimus, pimefylline, prScillardin, prospidium, prostalene, proSulpride, prosul pimelautide, pimetacin, pimethixene, pimetine, imetremide, tiamine, proterguride, protheobromine, prothipendyl, pro pimilprost, piminodine, pimobendan, pimonidazole, thixene, protiofate, protionamide, protirelin, protizinic acid, pimozide, pinacidil, pinadoline, pinafide, pinaverium, protokylol, protoporphyrin, protriptyline, proXZole, proxi pinazepam, pincainide, pindolol, pinokalant, pinolcaine, barbal, proxibutene, proxicromil, proxifeZone, proXorphan, pinoxepine, pioglitaZone, pipacycline, pipamazine, pipam proxymetacaine, proxyphylline, proZapine, prucalopride, perone, pipaZethate, pipebuZone, pipecuronium, pipemidi prulifloxacin, pruvanserin, pseudoephedrine, pumafentrine, cacid, pipendoxifene, pipenZolate, pipequaline, piperac pumaprazole, pumitepa, pumosetrag, puromycin, pyrabrom, etazine, piperacillin, piperamide, piperidolate, piperilate, pyrantel, pyrathiazine, pyrazinamide, pyrazofurin, pyricar piperocaine, piperonyl butoxide, piperoxan, piperphenidol. bate, pyridarone, pyridinol, pyridofylline, pyridostigmine, piperylone, pipobroman, pipoctanone, pipofeZine, piposul pyridoxal, pyridoxamine, pyridoxine, pyrilamine, fan, pipotiazine, pipoxizine, pipoxolan, pipradimadol, pyrimethamine, pyrimate, pyrinoline, pyrithione, pyrithyl pipradrol, pipramadol, pipratecol, piprinhydrinate, dione, pyritidium, pyritinol, pyrophenindane, pyrovalerone, pipocurarium, piprofurol, piprozolin, piquindone, piquizil, pyroxamine, pyrrobutamine, pyrrocaine, pyrrolifene, pyrro piracetam, pirandamine, pirarubicin, piraxelate, pirzmonam, liphene, pyrrolnitrin, pyrroxane, pyrvinium, pytamine, piraZolac, pirbenicillin, pirbuterol, pirdonium, pirenoxine, quadazocine, quadrosilan, quatacaine, quaZepam, quazi piremperone, pirezepine, pirepolol, piretanide, pirfenidone, none, quaZodine, quaZolast, quetiapine, quifenadine, qui pirbendil, piridicillin, piridocaine, piridoxilate, piridironic flapon, quillifoline, quilostigmine, quinacainol, quinacillin, acid, pirifibrate, pirimiphos-ethyl, pirindazole, pirinixic quinacrine, quinagolide, quinaldine blue, quinapril, quinap acid, pirinixil, piriprost, piriqualone, pirisudanol, piritra rilat, quinaZosin, quibolone, quincarbate, quindecamine, mide, piritrexin, pirlimycin, pirlindole, pirmagrel, pirmenol, quindonium, quindoxin, quinelorane, quinestradol, pirinabine, piroctone, pirodavir, priodomast, pirogliride, quinestrol, quinethaZone, quinetolate, quinezamide, quinfa piroheptine, pirolate, pirolaZamide, piromidic acid, piroX mide, quingestanol acetate, quingestrone, quinidine, qui antrone, piroXicam, piroxicillin, piroXimone, pirozadil, pir nine, quinotolast, quinpirole, quinterenol, quitiofos, quinu profen, pirquinozol, pirralkonium, pirsidomine, pirtenidine, clium, quinupramine, quinupristin, quipazine, quisultazine, pitenodil, pitofenone, pituxate, pivagabine, pivampicillin, rabeprazole, raclopride, ractopamine, radafaxine, rafox pivenfrine, pivopril, pivoxazepam, pixantrone, pizotyline, anide, ragaglitazar, ralitoline, raloxifene, raltitrexed, raluri plafbride, plaunotol, plauracin, pleconaril, pleuromulin, dine, ramatroban, ramciclane, ramelteon, ramifenaZone, plevitrexed, plicamuycin, plomestane, pobilukast, podilfen, ramipril, ramiprilat, ramixotidine, ramnodigin, ramnoplanin, podofilox, poldine, polymixin, polythiazide, pomisartan, ramorelix, ramosetron, ranelic acid, ranimustine, ranimycin, ponalrestat, ponaZuril, ponfibrate, porfiromycin, posacona ranirestat, ranitidine, ranolaine, rapacuronium, rasagiline, Zole, posatirelin, posiZolid, poskine, practolol, pradolfoxa rasburicase, rathyronine, ravuconazole, raZaxaban, razin cin, prajmalium, pralatrexate, pralidoxime, prailmorelin, odil, raZobazam, raZOxane, rebimastat, reboxetine, pralnacasan, pramipexole, pramiracetam, pramoxine, recainam, reclazepam, regadenoson, reglitazar, relcovaptan, prampine, pranazepide, pranidipine, prankulast, pranolium, relomycin, remacemide, remifentanil, remikiren, remipros pranoprofen, pranosal, prasterone, prasugrel, pratosartan, tol, remoxipride, renanolone, rentiapril, renzapride, repa pravadoline, pravastatin, praxadine, praZarelix, prazepam, glinide, reparixin, repinotan, repirinast, repromicin, reprot prazepine, praziquantel, praZitone, prazocillin, praZosin, erol, rescimetol, rescinnamine, resequinil, reserpine, preclamol, prednazate, prednazoline, prednicarbate, predni residuimod, resocortol butyrate, resorantel, resorcinol, reta mustine, prednisolamate, prednisolone, prednisone, predni pamulin, retelliptine, retigabine, retinol, revaprazan, revat val, prednylidene, pregabalin, pregnadiol, pregnenolone, ropate, revenast, reviparin, revizinone, revospirone, ribavi premafloxacin, premazepam, prenalterol, prenisteine, pren rin, riboflavin, riboprine, ribostamuycin, ricasetron, overine, prenoxdiazine, prenylamine, pretamazium, pretia ridazolol, ridogrel, rifabutin, rifalazil, rifametane, rifamexil, doil, prezatide, pribecaine, pridefine, prideperone, pridinol, rifamide, rifampin, rifapentine, rifaximin, rilapine, ril prifelone, prifinium, prifuroline, pilocalne, primaperone, makalim, rilmazafone, rillmenidine, rilopirox, riloZarone, primaquine, primidolol, primidone, primycin, prinomastat, rillpovorine, riluzole, rimantadine, rimazolium, rimcazole, prinomide, prinoXodan, pristinol, pristinamycin, prizidilol. rimexolone, rimiterol, rimonabant, rimoprogin, riodipine, proadifen, probarbital, probenecid, probicromil, probucol, rioprostil, ripazepam, ripisartan, risarestat, risedronicacid, US 2007/01 16729 A1 May 24, 2007

risocaine, risotilide, rispenzepine, risperidone, ristianol, ris Zole. Succisulfone, Suclofenide. Sucralfate. Sucralose, tocetin, ritanserin, ritometan, ritipenem, ritobegron, rito Sucrose octaacetate. SucroSufate, Sudexanox, Sudoxicam, drine, ritolukast, ritonavir, ritropirronium, ritrosulfan, rivar Sufenatil, Sufotidine, Sufugolix, Sugammadex, Sulamserod, Oxaban, rivastigmine, rivoglitaZone, rizatriptan, robalZotan, Sulazepam, SulaZuril, Sulbactam, Sulbenicillin, Sulbenox, robenidine, rocastine, rocepafant, rociclovir, rocuronium, Sulbentine, Sulbutiamine, Sulclamine, Sulconazole, Sulfa rodocaine, rodorubicin, rofecoxib, rofelodine, rofileponide, benz, Sulfabenzamide, Sulfabromomethazine, Sulfacarbam roflumilast, rogletimide, rokitamycin, rollafagrel, roletamide, ide, Sulfacecole, Sulfacetamide, Sulfachlorpyridazine, Sul rolgamidine, rolicyclidine, rolicyprine, rolipram, rollitetra fachrysoidine, Sulfaclomide, Sulfaclorazole, Sulfaclozine, cycline, rolodine, rolziracetam, romazarit, romergoline, Sulfacytine, Sulfadiazine, Sulfadimethoxine, Sulfadoxine, romifenone, romifidine, romurtide, ronactolol, ronidazole, Sulfaethidole, Sulfaguanidine, Sulfaguanole, Sulfalene, Sul ronifibrate, ronipamil, runnel, ropinirole, ropitoin, ropiv faloxic acid, SulfamaZone, Sulfamerazine, Sulfameter, Sul acaine, ropizine, roquinimex, rosaprostol, rosaramicin, rose famethazine, Sulfamethizole, Sulfamethoxazole, Sul bengal, rosiglitaZone, rosoxacin, rostafuroxin, rostaporfin, famethoxypyridazine, Sulfametmidline, sulfametrole, rosterolone, rosuvastatin, rotamicillin, rotigotine, rotoxam Sulfamonomethoxine, Sulfamoxole, Sulfanilamide, Sulfa ine, rotaxate, roXadimate, roXarsone, roXatidine acetate, nilate, Sulfaanitran, Sulfaperin, Sulfaphenazole, Sulfaproxy roxibolone, roxifiban, roXindole, roXithromycin, roXolo line, Sulfapyridine, Sulfaquinoxaline, Sulfarsphenamine, Sul nium, roXoperone, rubitecan, ruboxistaurin, rufinamide, fasalazine, Sulfasomizole, SulfaSuccinamide, Sulfasymazine, rufloxacin, rupatadine, rupintrivir, rutamycin, ruvaZone, Sulfathiazole, Sulfathiourea, Sulfatolamide, Sulfatroxazole, ruzadolane, Sabarubicin, Sabcomeline, sabeluzole, Sabi Sulfatrozole, Sulfazamet, Sulfinaolol, Sulfinpyrazone, Sul poride, Saccharin, Safingol, Safirinol, Sagandipine, salaceta firam, Sulfisomidine, Sulfisoxazole, Sulfobromophthalein, mide, Salafibrate, salantel, Salazodine, Salazosulfadimidine, Sulfonterol, Sulforidazine, Sulfosalicylic acid, Sulfoxone, Sul salaZoSulfamide, Salazosulfathiazole, Salcaprozoic acid, sal crinat, Sulindac, Sulisatin, Sulisobenzone, Sulmarin, Sulma colex, Salethamide, Salflucerine, Salicyl alcohol, Salicyla Zole, Sulmepride, Sulnidazole, Sulocarbilate, Suloctidil, Sulo mide, Salicylic acid, salinazid, salinomycin, salmefamol. dexide, Sulofenur, Sulopenem, Sulosemide, Sulotroban, salmeterol, Salmisteine, Salnacedin, Salprotoside, Salsalate, Suloxifen, Sulpiride, Sulprosal, Sulprostone, Sultamicillin, sameridine, Samixogrel, Sampatrilat, sampirtine, sancycline, Sultiame, Sultopride, Sultosilic acid, Sultroponium, Sulukast, Sanfetrinem, sanguinarium, Saperconazole, Saprisartan, Sulverapride, Sumacetamol, Sumanirole, Sumarotene, sapropterin, saquinavir, Sarafloxacin, Sarakalim, Saralasin, Sumatriptan, Sumetizide, Sunagrel, Suncillin, Sunepitron, sarcolysin, Sardomozide, Saredutant, Saripedem, Sarizotan, Supidimide, Supalast, Suproclone, Suprofen, Suramin, Suric SarmaZenil, Samoxicillin, Sarpicillin, Sarpogrelate, ainide, Suriclone, SuritoZole, Suronacrine, Susalimod, SuX saterinone, satigrel, satranidazole, satraplatin, saviprazole, emerid, SuXethonium, SuxibuZone, Symclosene, Synetine, savoxepin, scopafungin, scopinast, Scopolamine, Secalcif tabilautide, tabimorelin, tacalcitol, tacapenem, tacedinaline, erol, seclaZone, secnidazole, secobarbital, securinine, sede taclamine, tacrine, tacrolimus, tadalafil, tafluposide, camycin, Sedoxantrone, Seganserin, Segesterone, Seglitide, taglutamine, tagorizine, talampanel, talampicillin, talapor Selamectin, Selgiline, selfotel, Soldenoson, selprazine, fin, talastine, talbutal, taleranol, talibegron, talinolol, tal sampimod, sematilide, Semaxanib, semduramicin, semor ipexole, talisomycin, tallimustine, talmetacin, talmetoprim, phone, Semotiadil, Semustine, SenaZodan, Seocalcitol, sepa talnetant, talniflumate, talopram, talsalate, toloXimine, tal Zonium, Seperidol, sepimostat, seprilose, seproxetine, saclidine, talsupram, taltirelin, taltobulin, taltrimide, talu sequifenadine, seratrodast, Serazapine, serfibrate, Sergolex dipine, talviraline, tameridone, tameticillin, tametraline, ole, Sermetacin, sertindole, Sertraline, setastine, Setzindol, tamibarotene, tamitinol, tanolarizine, tamoxifen, tam setipafant, setiptiline, Setoperone, Sevitropium, Sevopra pramine, tamsulosin, tanaproget, tandamine, tandospirone, mide, Sezalamide, Sagoside, sibenadet. Sibopirdine, tandutinib, taniplon, tanomastat, tapentadol, taprizosin, tap Sibrafiban, Sibutramine, siccanin, Sifrprazine, siguaZodan, rostene, tarazepide, tariquindar, tasosartan, tasuldine, tauro silandrone, sildenafil. Silibinin, Silcristin, sildianin, silo lidine, tauromustine, tauroselcholic acid, taurosteine, taza dosin, silodrate, Silperisone, siltenZepine, simendan, sim dolene, tazanolast, tazarotene, taZaSubrate, taZeprofen, etride, Simfibrate, simtraZene, simvastatin, sincalide, sine taZifylline, taZiprinone, taZobactam, tazofelone, tazolol. fungin, Sinitrodil, sintropium, sipatrigine, Siramesine, tazometime, tebanicline, tebatizole, tebipenem, tebufelone, siratiazem, sirolimus, Sisomicin, Sitafloxacin, Sitalidone, tebuquine, tecadenoson, tecalcet, tecastemizole, teclthiaz Sitamaquine, sitaxentan, sitofibrate, sitoglusoide, sivelestat, ide, teclozan, tedisamil, tefazoline, tefenperate, teflufazine, Soblidotin, Sobuzoxane, Solabegron, Solifenasin, Solimastat, teflutiXol, tegafur, tegaserod, teglicar, teicopamin, telavancin, Solpecainol, Solypertine, Somatadine, Soneclosan, Sonepipra telbivudine, telenzepine, tellinavir, tellithromycin, telm Zole, sopitazine, Sopromidine, Soquinolol, Sorafenib, Sora esteine, telmisartan, teloxantrone, teludipine, temafloxacin, prazan, Sorbinicate, Sorbinil, Sorivudine, Sornidipine, Sotalol, temarotene, tematropium, temazepam, temefos, temelastine, Soterenol, Spaglumic acid, sparfloxacin, sparfosate, sparso temiverine, temocapril, temocaprilat, temocillin, temodox, mycin, Sparteine, spectinomycin, spiclamine, spiperone, Spi temoporfin, temozolomide, temisirolimus, temurtide, ten radoline, spiramide, spiramycin, spirapril, spiraprilat, amfetamine, tenatoprazole, tendamistat, tenidap, tenilapine, spirendolol, spirgetine, spirilene, spiriprostil, spirofylline, teniloxazine, tenilsetam, teniposide, tenivastatin, tenocycli spirogermanium, Spiroglumide, spiromustine, spironolac dine, tenofovir, tenofovir disoproxil, tenonitrozole, tenosal, tone, spiroplatin, spirorenone, Spirotriazine, SpiroXasone, tenosiprol, tenoxicam, tenylidone, teoprantil, teoprolol. spiroXatrine, spiroXepin, Spizofurone, Sprodiamine, tepirindole, tepoxalin, teprenone, teprotide, teraZosin, terbe squalamine, squalane, stacofylline, stillimycin, Stannsoprfin, quinil, terbinafine, terbogrel, terbucromil, terbufirol, terbu stanolone, stanoaolol, stavudine, Stearylsulfamide, Steflimy ficin, terbuprol, terbutaline, terciprazine, terconazole, terde cin, Stenbolone, strpronin, Stercuronium, Stevaladil, Stibam camycin, teerestigmine, terfeadine, terflavoxate, terfluranol, ine, Stibophen, Stilbamidine, stilbazium, Stilonium, Strima terguride, teriflunomide, terikalant, terizidone, terlakiren, Zole, Stiripentol, stirocainide, Stirofos, Streptomycin, terlipressin, ternidazole, terodiline, terofenamate, teroX streptonicozid, Streptonigrin, Streptozocin, styramine, Sub alene, teroxirone, tertatolol, tesaglitazar, tesicam, tesimide, athiazone, Subendazole. Succinylcholine. Succinylsulfathia tesimilifene, tesofensine, testolactone, testosterone, tetom US 2007/01 16729 A1 May 24, 2007

ilst, tetrabarbital, tetrabenazine, tetracaine, tetracycline, tet treosulfan, trepibutone, trepipam, trepirium, treprostinil, rahydrozoline, tetramethrin, tetramisole, tetraxetan, tet treptilamine, terquisin, tresperimus, trestolone, trethinium, razepam, tetraZolast, tetriprofen, tetrofosmin, tetronasin, trethocanoic acid, tretinoin, tretinoin tocoferil, tretoquinol, tetroquinone, tetroxoprin, tetrydamine, teverelix, texacro triacetin, triafungin, triamcinolone, triamcinolone acetonide, mil, tezacitabine, tezosentan, thalidomide, thebacon, triamcinolone benetonide, triamcinolone furetonide, tri thenalidine, thenium, thenyldiamine, theobromine, theo ampyZine, triamternem triaziquone, triazolam, tribendilol. drenaline, theofibrate, theophylline, thiabendazole, thiac tribenoside, tribromsalan, tribuZone, tricaprilin, tricetamide, etarsamide, thialbarbital, thiamazole, thiamine, thiamiprine, trichlorfon, trichlormethiazide, trichlomethine, triciribine, thiamphenicol, thamylal, thiaZesim, thiazinamium, thiazol triclabendazole, triclacetamol, triclazate, triclobisonium, tri sulfone, thiethyperazine, thihexinol ethylbromide, thimer clocarban, triclodazol, triclofenol, triclofos, triclofyllin, tri fonate, thimerosal, thiocolchicoside, thioctic acid, thio clonide, triclosan, tricyclamol, tridihexethyl, tridolgosir, tri furadene, thioguanine, thiohexamide, thioinosine, entine, triethylenemelamine, trifenagrel, trifeZolac, triflocin, thiopental, thiophanate, thiopropazate, thioproperazine, triflubazam, triflumidate, triflomeprazine, trifluperazine, tri thioridazine, thiosalan, thiostrpton, thiotepa, thiotetrabar fluperidol, triflupromazine, trifluidine, triflusal, trifosmin, bital, thiothixene, thiphenamil, thiphencillin, thiram, trigevolol, trihexylpheidyl, triletide, triloStane, trimaZosin, thonzonium, thonzylamine, thoZalinone, threonine, thy trimebutine, trimecain, trimedoxime, trimegestone, trimep mocartin, thymoctonan, thymol, thymopentin, thymotrinan, eridine, trimeprazine, trimetazidine, trimethadone, trimetha thyromedan, thyropropic acid, thyroxin, tiacrilast, tiadenol, mide, trimethaphan, trimethidinium, trimethobenzamide, tiafibrate, tiagabine, tiamenidine, tiametomnium, tiamulin, trimethoprim, trimetozine, trimetrexZate, trimexiline, trimi tianafac, tianeptine, tiapamil, tiapirinol, tiapride, tiaprofenic pramine, trimoprostil, trimoxamine, trioxifene, trioxsalen, acid, tiaprost, tiaramide, tiazofurin, tiaZuril, tiabalosin, tibe tripalmitin, tripamide, triparanol, tripelennamine, triplatin, glisene, tibenelast, tibenzate, tibeZonium, tibolone, tibric triprolidine, triptorelin, tritoqualine, trixolane, trizoxime, acid, tibrofan, ticabesine, ticalopride, ticarbodine, ticarcillin, trocimine, troclosene, trodusquemine, trofosfamide, trogli ticlatone, ticlopidine, ticolubant, ticrynafen, tidembersat, taZone, troleandomycin, tromanttadine, tropabazate, tro tidiacic acid, tiemonium, tienocarbine, tienopramine, tienox panserin, tropapride, tropatepine, tropenZiline, tropicamide, olol, tifemoxone, tifenazoxide, tiflamizole, tiflorex, tiflua tropigline, tropirine, tropisetron, tropodifene, troquidazole, dom, tiflucarbine, tiformin, tifurac, tigecycline, tigemonam, trospectomycin, trospium, trovafloxacin, troVirdine, troxac tigestol, tigloidine, tillargenine, tiletamine, tilidine, tiliq itabine, troXerutin, troXipide, troXolamide, troxonium, troxy uinol, tilisolol, tilmacoxib, tilmicosin, tilnoprofen, tilomi pyrrolium, truXicurium, truXipicurium, tryparsamide, tub sole, tillorone, tilozepine, tilsuprost, tiludonic acid, timcodar, ocurarine, tubulozole, tucaresol, tuclazepam, tulathromycin, timefurone, timegadine, timelotem, timepidium, timiperone, tulobuterol, tulopafant, turosteride, tuvatidine, tybamate, timirdine, timobesone acetate, timofibrate, timolol, timo tylosin, tymazolin, tyropanoate, tyrosine, tyrothricin, uben nacic, timoprazole, tinabinol, tinazoline, tinidazole, tinisul imex, ubidecarenone, ubisindine, ufenamate, ufiprazole, pride, tinofedrine, tinoridine, tiocarlide, tioclomarol, tio uldazepam, ulifloxacin, uliprisnil, umespirone, undecylenic conazole, tioctilate, tiodaZosin, tiodonium, tiomergine, acid, unoprostone, upenazime, upidosin, uracil, uracil mus tiomesterone, tioperidone, tiopinate, tiopronin, tiopropam tard, urapidil, uredepa, uredofos, urefibrate, ursodiol. ine, tioSpirone, tiotidine, tiotropium, tioxacin, tioXamast, urulcholic acid, utibapril, utibaprilat, Vadocaine, Valaciclo tioxaprofen, tioxidazole, tioXolone, tipentosin, tipepidine, Vir, Valconazole, Valdecoxib, Valdetamide, Valdipromide, tipetropium, tipifarnib, tipindole, tipranavir, tipredane, tipre Valethamate, vlaganiciclovir, Valine, Valnemulin, Vlanocta nolol, tiprinast, tiprodil, tiprostanide, tiportimod, tiqueside, mide, valofane, valomaciclovir, Valperinol, Valproate, Vlap tiquinamide, tiquizium, tiracizine, tirapazamine, tiratricol, roicacid, valpromide, Valrocemide, valrubicin, Valsartan, tirilazad, tirofiban, tiropramine, tisartan, tisocalcitate, Valorcitabine, Valtrate, Vamicamide, Vancomycin, Vandet tisocromide, tisopurine, tisoquone, tivanidazole, tiviciclovir, anib, Vaneprim, Vanitiolide, VanOXerine, Vanyldisulfamide, tivirapine, tixadil, tixanox, tiXocortol, tiZabrin, tizanidine, vapiprost, Vapreotide, Vardenfanil, Varenicline, Varespladib, tizolemide, tizoprolic acid, tobicillin, toborinone, tobramy Vatalanib, Vatanidipine, Vebufloxacin, vecuronium, Vedacli cin, tocainide, tocamphyl, tocladesine, tocofenoxate, tocofi dine, Vedaprofen, Velaresol, Velnacrine, Venlafaxine, Venriti brate, tocophersolan, todralazine, tofenacin, tofetridine, dine, Verodoline, Veralipride, Verapamil, Verazide, Verilo tofimilast, tofisoline, tofisppam, tolafentrine, tolamolol. pam, Verlukast, Verofylline, versetamide, Verteporfin, tolaZamide, tolboxane, tolbutamide, tolvapone, tolciclate, Vesnarinone, vestipitant, Vetrabutine, Vidarabine, vigabatrin, toldimfos, tolfamide, tolfenamic acid, tolgabide, tolimidone, VilaZodone, Vildaglipin, Viloxazine, vinbarbital, vinblastine, tolindate, toliodium, toliprolol, tolmesoxide, tometin, tolnaf Vinburnine, Vincamine, Vincanol, Vincofos, Vinconate, Vin tate, tolnapersine, tolnidamine, toloconium, tolonidine, tolo cristine, Vindeburnol, Vindesine, Vinpidine, Vinflunine, Vin nium, toloxatone, toloxychlorinol, tolpadol, tolpentamide, formide, Vinfosiltine, Vinglycinate, Vinleucinol, Vinleuro tolperisone, tolpiprazole, tolpronine, tolpropamide, tolpyr sine, Vinmegallate, Vinorelbine, vinpocetine, Vinpoline, ramide, tolduinzole, tolrestat, tolterodine, toltraZuril, tolu Vinrosidine, vintiamol, vintoperol, vintriptol, vinylbital, vin fazepam, tolvaptan, tolycaine, tomeglovir, tomelukast, Zolidine, viomycin, Viprostol, vidualine, Vicquidil, Virginia tomoglumide, tomoxiprole, tonabersat, tonazocine, topiluta mycin, Viridofulvin, ViroXime, Visnadine, Visnafylline, Vofo mide, topiramate, topixantrone, topotecan, toprilidine, pitant, Voglibose, volazocine, Volpristin, Voriconazole, topterone, toguizine, torbafylline, torcetrapib, torcitabine, Vorozole, Voxergolide, Xaliproden, Xamoterol, Xanomeline, toremifene, toripristone, torsemide, tosagestin, tosifen, to Su Xanoxic acid, Xanthinol, Xantifibrate, Xantocillin, Xantofyl floxacin, to Sulur, trabectedin, traboXopine, tracazolate, palmitate, Xemilofiban, Xenalipin, Xenazoic acid, Xenbucin, tradecamide, tralonide, tramadol, tramazoline, trandolapril, Xenipentone, Xenothiorate, Xenygloxal, Xenylhexenicacid, trandolaprilat, tranexamic acid, tranilast, transcainide, tran Xenylropium, Xibenolol, Xibornol. xidecaflur, Xilobam, telinium, tranycypromine, trapencaine, trapidil, travoprost, Ximelagatran, Ximoprofen, Xinidamine, Xinomiline, sipam traxanox, traxoprodil, traZitiline, trazium, traZodone, tra ide, Xipranolol. Xorphanol, Xylamidine, Xylazine, Xylocou Zolopride, trebenzomine, trecadrine, trecetilide, trefentanil, marol, Xylometazoline, Xyloxemine, yohimbic acid, Zab trelnarizine, treloxinate, trenbolone, trengestone, trenizine, icipril, Zabiciprilat, Zacopride, Zafirlukast, Zafiuleptine, US 2007/01 16729 A1 May 24, 2007

Zalcitabine, Zalderide, Zaleplon, Zalospirone, Zalitidine, Zal particular choices to accommodate these concerns. Similar toprofen, Zamifenacin, Zanamivir, Zanapezil, Zankiren, Zan concerns apply to the choice of anti-solvent. oterone, Zapizolam, Zaprinast, Zardaverine, Zatebradine, 0033. The lyophilization procedures herein can also be Zatosetron, Zelandopam, Zenarestat, Zenazocine, Zeniplatin, used to prepare rapidly disintegrating tablets that dissolve in Zepastine, Zeranol, Zetidoline, Zidapamide, Zidometacin, the mouth without the need for water to Swallow the tablet. Zidovudine, Zifrostilone, Zilantel, Zilascorb, Zileuton, Zil Currently available rapidly dissolving tablets (technology paterol, Zimeldine, Zimidoben, Zindotrine, Zindoxifene, Zin owned by Zydus) is only applicable to hydrophilic mol conazole, Zinostatin, Zinterol, Zinviroxime, Zipeprol, Ziprsi ecules having a low unit dose requirement (generally less done, Zocainone, Zofenopril. Zofenoprilat, Zoficonazole, than about 15 mg per dose) which do not require taste Zolamine, Zolasartan, Zolazepam, Zolendronic acid, Zolen masking. The current invention, on the other hand, permits Zepine, Zollertine, Zolimidine, Zoliprofen, Zolmitriptan, Zol creating a lyophilizate in a tablet mold so that the lyo operone, Zolpidem, Zomebazam, Zomepirac, Zometapine, philizate takes the shape of a tablet. Since the present Zonampanel, Zoniclezole, Zoniporide, Zonisamide, Zopi lyophilization method can omit virtually all auxiliary mate clone, Zopolrestat, Zorbamycin, Zorubicin, ZoSuquidar, rials if the drug doesn’t require taste masking, it is applicable Zotepine, Zoticasone, Zoxazolamine, Zucapsaicin, Zuclomi to materials having a high unit dose amount (hundreds to phene, Zuclopenthixol, and Zylofuramine. more than 1 gram per unit dose), as well as to those having 0032. The solvent, as mentioned, can be any liquid in Small unit dosage amounts. Furthermore, while the Zydus which the material dissolves; the solvent can be a single technology is available only with respect to hydrophilic Substance or a mixture of co-solvents, the important point materials, the present invention is applicable to both hydro being that the material to be lyophilized goes into solution. philic and hydrophobic materials. Solvents useful in the invention include materials that are 0034) Suitable, non-limiting, liquids for use as solvents, liquid at room temperature, dissolve the material, and are co-solvents, or anti-solvents, depending on the circum volatilizable or sublimatable at the temperature and pressure stances as outlined elsewhere in this specification include, conditions of the primary drying step discussed below. Since but are not limited to water, 5-7 membered heteroring not all solvents dissolve all materials, some of the potential systems (the heteroring systems having 1-3 heteroatoms, solvents will not be solvents in particular cases. Those of where the heteroatoms are oxygen or Sulfur, the Sulfur atoms ordinary skill will know which liquids are suitable as being unsubstituted or further carrying one or two oxygen solvents once the material to be lyophilized has been Substituents, except that two oxygen atoms cannot be in selected, by reference to standard texts in the field or by the adjacent ring positions, for example tetrahydrofuran (THF), conduct of simple dissolution testing of the material with the tetrahydropyran, dioxane, trioxane and other cyclic mono-, potential solvent. The chosen solvent will either alone di- and tri-ethers), lower alkanols (such as ethanol, propanol, dissolve the material or together with a co-solvent will isopropanol, sec-butanol, t-butyl alcohol, and n-butyl alco dissolve the material in question. Co-solvents are selected hol), or other organic solvents that freeze in the range of a from the same class as solvents, are miscible with the chosen lower temperature of about -100° C., preferably -90° C. Solvent, and generally aid the dissolution of the material in more preferably -80° C., and an upper temperature of not the solvent. Once the material in question is selected and the more than about 25°C., preferably not more than about 20° Solvent and any co-solvent is selected, the anti-solvent is C., even more preferably not more than about 15° C., still also selected from the same set of substances, but limited to more preferably not more than about 10° C. In addition, those which do not significantly dissolve the material, pref PEG 600-6000 and tocopherol succinate and acetate can also erably do not dissolve the material at all, and yet are miscible be used. with the chosen solvent/optional co-solvent system previ ously selected. For purposes of the present invention, Solu 0035) Preferably, the solvent is water, especially for bility of the material in the solvent or solvent/cosolvent hydrophilic materials. Water is preferred in the context of mixture is critical only in that the material needs to be pharmaceuticals, veterinary products, and foodstuffs dissolved. The concentration of the material in the solvent or because any residual solvent that remains with the solid is Solvent/co-solvent mixture is only of concern in certain innocuous once the lyophilizate is reconstituted with water. situations. For example, in pharmaceutical injectable for In applications in industries other than the above or where mulations, where the material is lyophilized in containers the freeze dried product is desired as a reactant in further that, once reconstituted in the container contain unit dosage reactions, other solvents, both within and beyond those set of the material for administration, materials requiring a forth above may be preferred as well and will be well within small unit dose may utilize a significant volume of “solvent' the ordinary skill of those in the art. Nonetheless, the solvent in the lyophilization procedure. However, where the mate must be one that is volatile or sublimates under the primary rial requires a large unit dose, the liquid chosen as the drying step conditions. Other preferable liquids for use in the solvent must necessarily be a much better solvent for the invention as the solvent or as the co-solvent or as the material so that the amount of solvent needed to dissolve the anti-solvent as dictated by the particulars of the material in unit dose is amenable to being placed in the lyophilization question include ethanol, tetrahydrofuran, and dioxane. container for processing economically. While these same concerns are important to bulk lyophilization procedures as 0036). If desired, a co-solvent may be used to aid in the well, they are less stringent than where the lyophilization dissolution of the material in the solvent. As stated above, containers are intended as the reconstitution container hav Such co-solvents are selected from the same group of liquids ing unit doses. Thus, the choice of a liquid as a solvent or a above, as long as the co-solvent is different from the solvent co-solvent not only depends upon the intrinsic ability to in question in the particular embodiment in question and dissolve the material in question, but on its relationship to miscible with the primary solvent so as to effect dissolution the amount of the solution that can be placed in the lyo of the material. Such co-solvents should be used as mini philization container intended to have a specific amount of mally as possible so as to avoid unnecessarily complicating end lyophilizate. Those of ordinary skill in the art will the solid product (potentially mixed solvate crystal forms or appreciate these concerns and be able to readily modify their mixed solvent amorphous associations, etc.), but there is no US 2007/01 16729 A1 May 24, 2007

other reason to avoid them and their use is within the scope however, require different reconstitution techniques than of the present invention. Where a co-solvent is utilized, it those for the hydrophilic materials. must also be one that is volatile or sublimates under the 0040 Again, it should be noted that for any given mate primary drying step conditions. rial, not all of the liquids listed above will be solvents for the specific material, however, a mere solubility test will deter 0037. If desired, the solution pH may be adjusted within mine if the particular solvent is suitable for a particular a range either to facilitate the solubility of the compound or material. If the material is soluble in the particular liquid, to provide a particular pH environment for optimum stability then the liquid is suitable as a solvent and/or co-solvent. If that is compatible with the end use of the lyophilizate. Thus, the material is not soluble in the liquid, then that is a for product that will be reconstituted with water for injec potential anti-solvent for that system if and only if it is also tion, with or without tonicity modifiers therein, the pH miscible with the solvent or solvent/co-solvent system being should be such that on reconstitution, a physiologically used. Suppose a material has a solubility in a liquid A of tolerated compatible pH is achieved. This is less of concern 1000 mg/ml, in liquid B of 100 mg/ml, in liquid C of 10 with materials that will be incorporated into more complex mg/ml, and in liquid D of 0.01 mg/ml. Further, Suppose that the material has a unit adult dose of 300 mg, a unit pediatric formulations or that will be used as reagents for further dose of 60 mg, and an infant unit dose of 12 mg. To prepare reactions. In these latter situations, the pH of the lyophilizate a suitable adult dose of the invention, one would use liquid does not necessarily correlate with its end pH so that a larger A (and possibly liquid B) as the solvent. Liquid D is an latitude of pH values in the lyophilizate are acceptable. clearly Suitable as an anti-solvent, but liquid C might also be suitable as the anti-solvent. To prepare a suitable pediatric 0038. In one embodiment of the invention, once the unit dose of the invention, one might use liquid A, but liquid Solution is obtained (and any desired pH adjustment and any B might be a better choice depending upon available equip desired filtration pre-material precipitation has taken place), ment precision. Liquid C, while it can be used as the the solution can be added to an anti-solvent for the material anti-solvent, since it can still dissolve an appreciable amount or can have such anti-solvent added to it. The purpose of this of the unit dose amount, it is preferably not so used, and the step is to force the material out of solution in a manner which better choice as the anti-solvent is liquid D. In preparing a will permit recovery of the desired form of the material. The Suitable infant unit dosage of the invention, liquid C is not anti-solvent is a substance which is not a solvent for the only not suitable as the anti-solvent (since it is capable of material, but is miscible with the solvent and, if present, any dissolving virtually the entire unit dosage amount, but co-solvent, used. The anti-solvent must also be a Substance precisely because of this, it might actually be suitable for use that can be removed in the context of the freeze-drying itself. as the solvent while liquid D would be the anti-solvent. Thus, it is a substance which is volatile or sublimes at the Thus, given the particulars of the individual situation of the temperature and pressure used in the primary drying step of various solubilities in the various liquids as potential solvent the freeze-drying process. As stated above, the anti-solvent and anti-solvents, and the specifics of the unit dosage is selected from the same group of liquids set forth above, amounts needed to be in the lyophilized product, a single except that for use as an anti-solvent, the liquid must adhere liquid may be a solvent in Some cases and yet an anti-solvent to the constraints of this paragraph with respect to the in others even for the same material intending to be lyo particular material/solvent/optional co-solvent system in philized. Thus, while some testing is necessary to determine question. the specifics of the systems within the invention, such is well within the abilities of one of ordinary skill in the art. 0039. In another embodiment of the invention, in which Generally, liquids that are Suitable as solvent or co-solvents the material is hydrophobic or lipophilic, the solvent is for hydrophilic materials are likely to be anti-solvents for selected from, 5-7 membered heteroring systems (the het hydrophobic or lipophilic materials, while anti-solvents for eroring systems having 1-3 heteroatoms, where the heteroa hydrophilic materials are likely to be solvents and co toms are oxygen or Sulfur, the Sulfur atoms being unsubsti solvents for hydrophobic and/or lipophilic materials. Simi tuted or further carrying one or two oxygen Substituents, larly, liquids that are solvents and/or co-solvents for hydro except that two oxygen atoms cannot be in adjacent ring phobic and/or lipophilic materials are likely to be anti positions, for example tetra hydrofuran (THF), tetrahydro solvents for hydrophilic materials, while carriers that are pyran, dioxane, trioxane and other cyclic mono-, di- and anti-solvents for hydrophobic and/or lipophilic materials are tri-ethers). The use of these liquids as solvents in the likely to solvents or co-solvents for hydrophilic materials. lyophilization process is new to the lyophilization art. In 0041. The material/solvent/co-solvent (if present)/anti addition, in the lyophilization of hydrophobic or lipophilic solvent (if present) system is then frozen and the frozen materials according to the invention, lower alkanols (metha product is subjected to vacuum to sublimate or volatilize the nol, ethanol, propanol, isopropanol, n-butanol, sec-butanol, Solvent, so-solvent/anti-solvent components. or t-butanol), liquid ketones, liquid (oxygen or Sulfur) 0042. In general, in the embodiments in which anti ethers, liquid (oxygen or Sulfur) ketones, liquid (oxygen or solvent is utilized, once the solution of the material is Sulfur) esters or thioesters may also be used as the liquid formed in the solvent or solvent/co-solvent mixture, the Solvent. In these embodiments, in addition to utilizing the Solution is mixed with anti-solvent in a proportion in the anti-solvent as indicated above, the system can omit the range of about 5:1 to about 1:5, preferably about 4:1 to about anti-solvent and directly lyophilize the solution of the mate 1:4, more preferably about 3:1 to about 1:3; even more rial in these liquids, in a manner completely analogously to preferably about 2:1 to about 1:2, still more preferably about completely aqueous lyophilization techniques. When omit 1.5:1 to about 1:1.5, still even more preferably about 1:1 on ting the anti-solvent, the preferred solvents are the heteror a volume/volume basis of (solvent and/or-solvent):(anti ing solvents discussed above. The lyophilizate here as with solvent). the resultant lyophilizate of hydrophobic and lipophilic 0043. The addition of the anti-solvent causes the material embodiments when using the anti-solvent process above do, to come out of solution. This precipitation can be allowed to US 2007/01 16729 A1 May 24, 2007

continue for as long as desired before the freezing step takes easily removed during the lyophilization. Optionally, the pH place, but the slower the precipitation, the greater the can be adjusted to into the range of about 7 to about 8 prior likelihood that the precipitated material will adopt a crys to adding the anti-solvent. talline conformation. The speed of precipitation and thus the 0048. In another preferred embodiment, a slurry is made degree of crystallinity or amorphous character can be con using ceftazadime and water. The pH is adjusted to about 5 trolled by the ratio of anti-solvent to solvent/co-solvent to about 7 using NaOH to facilitate the dissolution of utilized as well as the speed of the addition when adding ceftazidime. Once Solution is effected, an anti-solvent, Such anti-solvent to the solvent/co-solvent/material solution as as THF, dioxane or one of the other liquid heteroring well as freezing conditions. The reverse addition of solvent/ compounds is added to precipitate the ceftazadime, which is co-solvent/material to anti-solvent results in a very rapid then frozen and dried. In this embodiment, lower alkanols, precipitation since the ratio of anti-solvent to solvent/co Such as ethanol, n- or iso-propanol, or n-, sec-, or t-butanol Solvent is always very high during the addition. may also be used as the anti-solvent. The same procedure is 0044. Once the precipitation is effected (or once the generally applicable to other cephalosporins, especially to dissolution is effected in the embodiments that omit the ceftrioxone and cephradine. anti-solvent), the mixture is frozen in a cooling step that is typically over a period of about 30 min to 10 hours, 0049. In another embodiment, a slurry of cefapime is preferably about 1 our to about 8 hours, more preferably made in water. The pH is adjusted to about 1 to about 3 with about 2 hours to about 7 hours, typically about 4 to about 6 HCl (or other suitable inorganic acid) to facilitate dissolu hours to result in a frozen mass. A quick freezing generally tion. Once dissolved, anti-solvent (liquid herteroring com favors amorphous product, while a slow cooling generally pounds) is added to precipitate the cefapime, and the result favors a more crystalline product; however, this is only a is freeze dried. general guideline, and particular results can vary depending 0050. In a further embodiment, cyclophosphamide (spar on a number of conditions. If desired, prior to freezing, the ingly soluble in water but highly soluble in ethanol) is mixture can be filtered so that the bulk of the solvent/co dissolved in one or more of the liquid hetero-ring com solvent/anti-solvent is removed/recovered leaving behind a pounds and/or lower alkanols to form a concentrated solu precipitate wet with some of the solvent/co-solvent/anti tion. Water is then added as an anti-solvent to precipitate the solvent mixture, which is then subjected to the freezing step. crystalline cyclophosphamide monohydrate or anhydrate. (This procedure applies especially when preparing sterile The result is then freeze-dried. bulk, not unit dose vials for parenteral administration). 0051. In another particularly preferred embodiment, itra 0045. Once frozen, the mass is subjected to a vacuum conazole is the hydrophobic/lipophilic material and a non pressure whereby a substantial portion, if not all of the aqueous liquid is selected as a solvent to dissolve it. An remaining solvent/co-solvent/anti-solvent is volatilized off anti-solvent is not needed to lyophilize the hydrophobic/ during primary drying. Remaining residual amounts of one lipophilic molecule. The non-aqueous solvents to dissolve or more of Solvent and/or co-solvent and/or anti-solvent are lipophilic molecules are listed in paragraph 0034-0036. In removed in a secondary drying step. Generally, during the addition ethanol and PEG 600-6000 and tocopherol succi primary drying the product temperature is maintained below nate and acetate can also be used as solvents to Solubilize O'C while in the secondary drying the product temperature lipophilic materials. Once the material is dissolved in the will be maintained at about 25 to 40° C., although other non-aqueous solvent, it is filtered asceptically to remove any primary and secondary drying temperatures may be suitably undesired components and microorganisms and filled into found in the ordinary course by those of ordinary skill in the vials and lyophilized either using the conventional lyo art. philization procedures or special procedures depending on the nature and amount of non-aqueous solvents used to 0046) The lyophilizates prepared according to the inven dissolve the material. The lyophilizate can be reconstituted tion can be prepared in situ in the container that will be used with minimum Volume of pharmaceutically acceptable sol for reconstitution; in molds (or blister packs) for preparing vent (typically polyethylene glycol or liquid PEGs) to pre rapidly dissolving tablets; or can be prepared in bulk for use pare a liquid concentrate. The liquid concentrate is further in any other processes or reactions as desired. Thus, bulk diluted to a desirable concentration in a special diluent or chemicals can be prepared and packaged for blending with commercially available Intralipid fat emulsions, or plasma other components at a user's convenience or need. Similarly or serum or in whole blood prior to administering to patients. small portions of lyophilizates of the invention may be One aspect of the novelty of this embodiment of the inven prepared in unit of use containers and packed with dissolu tion is that patient’s blood can be used to dilute the liquid tion media in Suitable kits for ease of preparing single units concentrate and administer back into the patients blood of use. stream. Since these molecules are lipophilic, they will 0047. In one particularly preferred embodiment, amifos partition into the lipid layer of the fat emulsion or blood. tine (a highly water soluble material) is the hydrophilic 0052. In a still further embodiment, itraconazole is dis material, water is selected as the solvent, and tetrahydrofu Solved in non-aqueous liquid Such as THF at a very high ran is selected as the anti-solvent. Also, tetrahydropyran, concentration. Itraconazole is generally considered soluble dioxane, trioxane and the other liquid heteroring compounds in methylene chloride only. We surprisingly found that high mentioned in paragraphs 0034-0036 can be used as anti concentrations of itraconazole can be dissolved in the non solvents for amifostine when water is the solvent. Of the aqueous solvents listed in the paragraph 0034-0036 in the aforementioned solvents, dioxane offers special advantages presence of small quantities of HC1. The itraconazole thus over other organic solvents. Dioxane freezes below 15°C dissolved in the non aqueous solvent is lyophilized. The and Sublimates rapidly under vacuum. Use of dioxane as an lyophilizate is reconstituted to 100 mg/ml Solution using anti-solvent does not require any solvent trap and can be pharmaceutically acceptable solvent, typically propylene lyophilized similar to completely aqueous lyophilization. glycol. The liquid concentrate is further diluted with 25 ml Similarly trioxane also has a low meting point and can be or more of 10% Intralipid fat emulsion. The aqueous and oil US 2007/01 16729 A1 May 24, 2007 phase of the emulsion is separated by using an ultracentri previously discussed, can be utilized in the preparation of fuge and it is observed that all the itraconazole is partitioned injectable final products as well as in rapidly dissolving oral into the fat layer of the emulsion. dosage forms. In addition, they can be utilized in the 0053 While some embodiments seek to eliminate auxil preparation of other oral dosage forms (tablets, capsules, iary components in the lyophilization process, not all aux powders, etc) for ingestion as is or for rapid dissolution in iliaries need be eliminated. Thus, as desired, the solution liquids for ingestion. Still further, the lyophilizates can be prepared prior to any precipitation of the material and prior applied topically as is to wet or “weeping? oozing Surfaces to any freezing step can have suitable auxiliary materials for administration. These include, without limitation topical Such as building agents, buffers, and anti-oxidizing agents. application to open or oozing wounds, as well as to mucous Each of the auxiliary agents must be compatible with the end membranes. Inhalation of lyophilizate powder for applica use or be capable of being removed prior to use (as when the tion to the nose and bronchial tree, as well as instillation of lyophilizate is being used in further reactions or where the the powder to the eye, oral mucosa, rectum, vaginal, uterine, subsequently purified product will have the non-acceptable urethral, and urinary bladder tissues are contemplated by the material removed prior to that product being used). Bulking present invention. In addition, the lyophilzates can be rap agents that are generally Suitable are those which raise the idly dissolved in appropriate liquid media for administration glass transition temperature of the material being lyo to these tissues as well. philized. For pharmaceuticals these generally include, but are not limited to, saccharides (such as fructose, Sucrose, EXAMPLES lactose, trehalose, and others), polyvinylpyrrolidone, and cyclodextrins, the Saccharides being preferred, and trehalose Example 1 being a particularly suitable material. Complexing/solubi lizing agents include niacinamide and other cyclic amide, 0056. A sufficient amount of amifostine is dissolved in gentisic acid, cyclodextrins and Surfactants with HLB values water to result in a concentration in the range of 100 to 500 ranging from 1 to 16. Nonetheless, in most instances, the mg/ml. The solution is asceptically filtered through a 0.2 invention permits the omission of the bulking agent, and the micron filter (Pall filter membrane Nylon 66 or any com absence of bulking agent is a preferred embodiment. For patible filter). Separately, tetrahydrofuran is asceptically pharmaceutical purposes, buffers can be, but are not limited filtered using a Pall filter membrane Nylon 66.2 ml of the to, amino acids, inorganic buffers, mono- and di-carboxylic filtered amifostine solution is placed in a 5 ml USP type 1 acid buffers, hydroxyl-mono- and di-carboxylic acid buffers, pre-sterilized and depyrogenated flint vial and 1 ml of the amines, and Sulfonamides. The antioxidants include, but are filtered THF is added thereto. The vial contents become not limited to, different class of bisulfites, ascorbic acid, disodium- and tetrasodium EDTA, citrates as metal ion cloudy. The vials having the amifostine, water, and THF are chelators, BHA, BHT, sulfoxylates, propyl gallate, amino placed onto a lyophilization tray, which is then introduced acids containing thio group Such as methionine, and thiols as into a lyophilization chamber. The chamber temperature is well as other antioxidants listed in the FDA website for set to -30° C. When the product temperature reaches -25° inactive ingredients used in pharmaceutical dosage forms. C., the condenser is turned on at a setting of -50° C. or 0054 Lyophilizates of the present invention have signifi below. When the condenser temperature reaches -40°C., the cantly improved stability over materials prepared without vacuum pump is turned on and the vacuum monitor gauge lyophilization or prepared via current lyophilization tech is adjusted to 200 microns. When the vacuum reaches 200 niques other than those of the invention. For example, a microns, the shelf temperature is set to -5° C. and the completely water lyophilization of amifostine results in a product is dried for 12 hours. At the conclusion of the 12 material that degrades to 80% of its initial amifostine hours, the shelf temperature is reset to 30° C. and the product amount in 30 days, when stored at 40° C. Amorphous is dried for an additional 15 hours. The equipment is bleeded amifostine lyophilizate of the invention using water as the with nitrogen to bring the pressure back to atmospheric Solvent and tetrahydrofuran as the anti-solvent, stored under pressure, the vials are stoppered, and sealed with aluminum the same conditions, results in degrading to only 98% of its caps. initial amount in 30 days and to 90% of its initial amount in 90 days. Example 2 0.055 The lyophilizates of the present invention (when 0057 Example 1 is repeated with the following variations limited to pharmaceutical and veterinary active agents, as as set forth in Table I

TABLE I

AMIFOSTINE THF FREEZE PRIMARY SECONDARY SAMPLE AMOUNT AMOUNT TEMP DRY TIME DRY TIME 100 mg 0.1 ml -40 12 HOURS 12 HOURS 200 mg 0.1 ml -40 2OHOURS 2OHOURS 300 mg 0.1 ml -40 12 HOURS 12 HOURS 400 mg 0.1 ml -40 12 HOURS 12 HOURS 500 mg 0.1 ml -40 12 HOURS 12 HOURS 100 mg 0.25 ml -30° 1S HOURS 1S HOURS 200 mg 0.25 ml -30° 1S HOURS 1S HOURS 300 mg 0.25 ml -20 18 HOURS 1S HOURS 400 mg 0.25 ml -20 18 HOURS 1S HOURS 500 mg 0.25 ml -40 2OHOURS 1S HOURS 100 mg 0.5 ml -350 2OHOURS 1S HOURS US 2007/01 16729 A1 May 24, 2007

TABLE I-continued

AMIFOSTINE THF FREEZE PRIMARY SECONDARY SAMPLE AMOUNT AMOUNT TEMP DRYTIME DRYTIME L 200 mg O.S in -350 4 HOURS 8 EHOURS M 300 mg 0.5 ml -20° 4 HOURS 8 EHOURS N 400 mg 0.5 ml -25 3 HOURS 8 EHOURS O 500 mg 0.5 ml -25 3 HOURS 8 EHOURS P 100 mg 1 ml -20° 2 HOURS 8 EHOURS Q 200 mg 1 m -30° SHOURS 15 EHOURS R 300 mg 1 m -30° SHOURS 15 EHOURS S 400 mg 1 ml -20° 8 HOURS 15 EHOURS T 500 mg 1 ml -20° 8 HOURS 15 EHOURS U 100 mg 2 In -40° 20 HOURS 15 EHOURS V 200 mg 2 m -35° 2O HOURS 15 EHOURS W 300 mg 2 ml -350 4 HOURS 8 EHOURS X 400 mg 2 ml -20° 4 HOURS 8 EHOURS Y 500 mg 2 ml -25° 3 HOURS 8 EHOURS whereby suitable lyophilizates can be obtained. solution is placed in a 5 ml USP type 1 pre-sterilized and depyrogenated flint vial and 1 ml of the filtered water is Example 3 added thereto. The vial contents become cloudy. The vials having the itraconazole, water, and THF are placed onto a 0.058 Example 2 is repeated using dioxane as the anti lyophilization tray, which is then introduced into a lyo solvent, whereby suitable lyophilizates can be obtained. philization chamber. The chamber temperature is set to -30° Examples 4-7 C. When the product temperature reaches -25° C., the condenser is turned on at a setting of -50° C. or below. 0059 Examples 2-3 are repeated except that amifostine is When the condenser temperature reaches -40° C., the replaced (a) with ceftazadine with the water having a pH of vacuum pump is turned on and the vacuum monitor gauge 5-7 (Examples 4-5) or (b) with cefapine with the water is adjusted to 200 microns. When the vacuum reaches 200 having a pH of 1-3, whereby suitable lyophilizates can be microns, the shelf temperature is set to -5° C. and the obtained. product is dried for 12 hours. At the conclusion of the 12 hours, the shelf temperature is reset to 30° C. and the product Example 8 is dried for an additional 15 hours. The equipment is bleeded 0060) A sufficient amount of itraconazole is dissolved in With nitrogen to bring the pressure back to atmospheric acidified tetrahydrofuran to result in a concentration in the pressure, the vials are stoppered, and sealed with aluminum range of 100 to 500 mg/ml. The solution is asceptically caps. filtered through a 0.2 micron filter (Pall filter membrane Nylon 66 or any compatible filter). Separately, water is Example 9 asceptically filtered using a Pall filter membrane Nylon 66 0061 Example 8 is repeated with the following variations (or any compatible filter). 2 ml of the filtered itraconazole as set forth in Table II

TABLE II

INTRACONAZOLE THF FREEZE PRIMARY SECONDARY SAMPLE AMOUNT AMOUNT TEMP DRY TIME DRY TIME A. 100 mg 1 m -40 2 HOURS 2 HOURS B 200 mg 2 m -40 2OHOURS 2OHOURS C 300 mg 3 m -40 2 HOURS 2 HOURS D 400 mg 4 m -40 2 HOURS 2 HOURS E 500 mg 5 m -40 2 HOURS 2 HOURS 100 mg 1 m -30° SHOURS SHOURS G 200 mg 2 m -30° SHOURS SHOURS H 300 mg 3 m -20 8 HOURS SHOURS I 400 mg 4 m -20 8 HOURS SHOURS J 500 mg 5 m -40 2OHOURS SHOURS K 100 mg 1 m -350 2OHOURS SHOURS 200 mg 2 m -350 4 HOURS 8 HOURS M 300 mg 3 m -20 4 HOURS 8 HOURS N 400 mg 4 m -25 3 HOURS 8 HOURS O 500 mg 5 m -25 3 HOURS 8 HOURS C 100 mg 1 m -20 2 HOURS 8 HOURS Q 200 mg 2 m -30° SHOURS SHOURS R 300 mg 3 m -30° SHOURS SHOURS S 400 mg 4 m -20 8 HOURS SHOURS 500 mg 5 m -20 8 HOURS SHOURS U 100 mg 1 m -40 2OHOURS SHOURS US 2007/01 16729 A1 May 24, 2007 21

TABLE II-continued

INTRACONAZOLE THF FREEZE PRIMARY SECONDARY SAMPLE AMOUNT AMOUNT TEMP DRY TIME DRY TIME V 200 mg 2 ml -350 2OHOURS 1S HOURS W 300 mg 3 ml -350 14 HOURS 18 HOURS X 400 mg 4 ml -20 14 HOURS 18 HOURS Y 500 mg 5 ml -25 13 HOURS 18 HOURS whereby suitable lyophilizates can be obtained. being unsubstituted or further carrying one or two oxygen Substituents, except that two oxygen atoms cannot be in Example 10 adjacent ring positions. 0062) Example 9 is repeated using dioxane as the solvent 5. The method of claim 4 wherein said solvent is selected w whereby suitable lyophilizates can be obtained. from the group consisting of tetra hydrofuran, tetrahydro pyran, dioxane, and trioxane. Examples 11-12 6. The method of claim 1 wherein said lyophilizate is a thermally stable product even in the absence of a stabilizer, 0063 Examples 9-10 are repeated except that the water where thermally stable means that on storing said lyo anti-solvent is omitted, whereby suitable lyophilizates can philizate for a period of at least 18 months at room tem be obtained. perature and humidity, the amount of degradation of said material over said period is no more than about 20% w/w. Example 13-17 7. The method of claim 2 wherein said material, when 0064. Example 9 is repeated using ethanol (Example 13), recovered from solution thereof in said solvent in at least one tetrahydropyrane (Example 14), isopropanol (Example 15), manner other than the process of claim 1 exists in an tocopherol acetate (Example 16), or tocopherol Succinate unstable water-sensitive amorphous form or an unstable (Example 17) as the solvent whereby suitable lyophilizates water-sensitive crystalline solvate form. can be obtained. 8. The method of claim 1 further comprising adding a co-solvent for said material to said solvent before, during, or after said step (a) but before step (b). We claim: 9. The method of claim 1 where said solvent is other than 1. A method of lyophilizing a material comprising: C-C mono- or di-hydric alcohol. 10. The method of claim 1 wherein said solvent comprises (a) dissolving said material in a solvent for said material at least water. to form a solution; or making a slurry of the material 11. The method of claim 8 wherein said co-solvent is other and adjusting the pH to dissolve the drug to form a than C-C mono- or di-hydric alcohol and wherein said Solution co-solvent is volatilizable or sublimable under freeze-drying (b) adding a non-solvent for said material to said solution, conditions. which non-solvent is miscible with said solvent to force 12. The method of claim 1 wherein said non-solvent is said material at least partially out of said solution, and other than a C-C mono- or di-hydric alcohol. wherein said non-solvent is volatilizable under freeze 13. The method of claim 12 wherein said non-solvent is drying conditions; other than a C-C mono-, di-, or tri-alcohol that is liquid when said non-solvent is at room temperature and pressure. (c) freezing the result of step (b) to yield a frozen result: 14. The method of claim 13 wherein said non-solvent is and other than a C-C mono-, di-, or tri-alcohol. (d) vacuum drying the frozen result of step (c) to yield a 15. The method of claim 11 wherein said co-solvent is lyophilizate. other than a C-C mono-, di-, or tri-alcohol that is liquid 2. The method of claim 1 wherein said material is when said co-solvent is at room temperature and pressure. hydrophilic and said non-solvent is selected from the group 16. The method of claim 15 wherein said co-solvent is consisting of 5-7 membered heteroring systems, the heter other than a C-C mono-, di-, or tri-alcohol. oring systems having 1-3 heteroatoms, where the heteroat 17. The method of claim 1 which is substantially free of oms are oxygen or Sulfur, the Sulfur atoms being unsubsti lyophilization stabilizers other than pH stabilization for said tuted or further carrying one or two oxygen Substituents, material on a material-by-material basis. except that two oxygen atoms cannot be in adjacent ring 18. The method of claim 17 which is substantially free of positions. all lyophilization stabilizers. 3. The method of claim 2 wherein said non-solvent is 19. The method of claim 18 which is free of all lyophiliza selected from the group consisting of tetra hydrofuran, tion stabilizers. tetrahydropyran, dioxane, and trioxane. 20. A method of lyophilizing a hydrophobic and/or lipo 4. The method of claim 1 wherein said material is philic material comprising: hydrophobic and/or lipophilic and said solvent is selected (a) dissolving said material in a solvent for said material from the group consisting of 5-7 membered heteroring to form a solution, said solvent being selected from the systems, the heteroring systems having 1-3 heteroatoms, group consisting of 5-7 membered heteroring systems, where the heteroatoms are oxygen or Sulfur, the Sulfur atoms the heteroring systems having 1-3 heteroatoms, where US 2007/01 16729 A1 May 24, 2007 22

the heteroatoms are oxygen or Sulfur, the Sulfur atoms 32. A method of reconstituting a lyophilizate claim 22 being unsubstituted or further carrying one or two comprising preparing a highly concentrated Solution of said oxygen Substituents, except that two oxygen atoms lyophilizate in a small amount of an initial diluent selected cannot be in adjacent ring positions.; from the group consisting of liquid polyethyleneglycol and propylene glycol. (b) optionally forcing said material at least partially out of 33. The method of claim 32 further comprising further Solution by adding a non-solvent for said material to diluting said concentrated Solution with a diluent selected said solution, which non-solvent is miscible with said from the group consisting of commercially available solvent and wherein said non-solvent is volatilizable or Intralipid fat emulsions, plasma, serum, in whole blood. Sublimable under freeze-drying conditions; 34. A method of preparing an oral dosage form of a (c) freezing material comprisinglyophilizing said material in accordance with the method of claim 1, wherein said material is an (i) the result of step (a) if step (b) is omitted or orally administrable compound, and forming said result into (ii) the result of step (b) if step (b) is practiced; said oral dosage form. 35. A method of preparing an oral dosage form of a to yield a frozen result; and material comprisinglyophilizing said material in accordance (d) vacuum drying the frozen result of step (c) to yield a with the method of claim 20, wherein said material is an lyophilizate: orally administrable compound, and forming said result into 21. A lyophilized compound or composition prepared by said oral dosage form. the method of claim 1. 36. The method of claim 34 wherein said oral dosage form 22. A lyophilized compound or composition prepared by is a rapidly dissolving tablet. 37. The method of claim 35 wherein said oral dosage form the method of claim 20. is a rapidly dissolving tablet. 23. The method of claim 1 which is substantially free of 38. The oral dosage form of claim 34. monosaccharides. 39. The oral dosage form of claim 35. 24. The method of claim 1 which is substantially free of 40. A topical and/or inhalable dosage form comprising a disaccharides. lyophilizate of claim 1, wherein said material is a topical 25. The method of claim 1 which is completely free of and/or inhalation administrable compound in said lyo mono and di Saccharides. philizate form. 26. The method of claim 20 which is substantially free of 41. A topical and/or inhalable dosage form comprising a monosaccharides. lyophilizate of claim 20, wherein said material is a topical 27. The method of claim 20 which is substantially free of and/or inhalation administrable compound in said lyo disaccharides. philizate form. 28. The method of claim 20 which is completely free of 42. A method of applying a material to a target Surface, mono and di Saccharides. wherein said material is a pharmaceutically or veterinary 29. The method of claim 1 wherein said material is active agent comprising lyophilizing said material according selected from the group consisting of alfentanil, amifostine, to claim 1 and (a) directly applying said lyophilizate or (b) aminophyllin, amoxicillin, amplicillin, bupivacaine, caffeine, dissolving said lyophilizate in an appropriate diluent media cefepime, ceftazidime, ceftriaxone, cephradine, chromic for the route of administration and then applying the diluted chloride, clindamycin, codeine, cyclophosphamide, cys lyophilizate (1) by inhalation to the nose, bronchial tree, teine, dextrose, doxapram, doxycycline, edetate, hyos and/or lung or (2) by instillation to the eye, oral mucosa, cyamine, levorphanol, lidocaine, lincomycin, menadiol), rectum, vaginal, uterine, urethral, and urinary bladder tis neropenam, metoclopramide, morphine, nafcillin, norepi SUS. nephrine, ondansetron, oxacillin, oxytetracycline, piperacil 43. A method of applying a material to a target Surface, lin, scopalamine, spectinomycin, Succinylcholine, theophyl wherein said material is a pharmaceutically or veterinary line, thiothixene, tubocurarine, moxifloxacin, tacrolimus, active agent comprising lyophilizing said material according itraconazole, argatroban, posaconazole, Voraconizole, doc to claim 20 and (a) directly applying said lyophilizate or (b) etaxel, fludarabine, glatiramer acetate, gemcitabine, irinote dissolving said lyophilizate in an appropriate diluent media can, epoprostenol, and 7-ethyl-10-hydroxy camptothecin, for the route of administration and then applying the diluted and pharmaceutically acceptable salts, amides, Sulfona lyophilizate (1) by inhalation to the nose, bronchial tree, mides, amides, carbamates, esters, and phosphoesters and/or lung or (2) by instillation to the eye, oral mucosa, thereof, and amorphous and crystalline forms of any of the rectum, vaginal, uterine, urethral, and urinary bladder tis foregoing, and anhydrate and hydate and Solvate forms of SUS. any of the foregoing. 44. The lyophilizate of claim 1 when said material (a) is 30. A method of reconstituting a lyophilizate claim 21 hydrophobic or (b) is hydrophilic and/or lipophilic, or of wherein said material is hydrophobic and/or lipophilic com claim 20 when said material is hydrophobic and/or lipophilic prising preparing a highly concentrated Solution of said wherein said material is selected from the group consisting lyophilizate in a small amount of an initial diluent selected of abacavir, abamectin, abanoquil, abaperidone, abarelix, from the group consisting of liquid polyethyleneglycol and abecamil, abiraterone, abitesartan, ablukast, abunidazole, propylene glycol. acadesine, acamprosate, acaprazine, acebrochol, acebutolol. 31. The method of claim 30 further comprising further acecainide, acecarbromal, aceclidine, aceclofenac, acedap diluting said concentrated Solution with a diluent selected Sone, acediasulfone, acedoben, acefluranol, acefurtiamine, from the group consisting of commercially available acefylline clofibrol, acefylline piperazine, aceglatone, ace Intralipid fat emulsions, plasma, serum, in whole blood. glutaminde, acemetacin, aceneuramicacid, acenocoumarol, US 2007/01 16729 A1 May 24, 2007 acepeprone, acepromazine, aceprometazine, acequinoline, amoxecaine, amoxicillin, amoxydramine, amperozide, acesulfame, acetaminosalol, acetanilide, acetarSone, anphechloral, amphenidone, amphetamine, amphomycin, acetaminophen, acetazolamide, acetiamine, acetiromate, amphotalide, amphotericin, amplicillin, ampiroxicam, acetohexamide, acetophenaZone, acetophenetidin, acetor amprenavir, amprolium, ampyrimine, ampyZine, amduinate, phine, acetosulfone, acetriozoic acid, acetylcysteine, acetyl amrubicin, amsacrine. amtolimetin, amustaline, amylobar digitoxin, acetylleucine, acetyltributyl citrate, acetyltriethyl bital, angestone, anagrelide, anakinra, anaritide, anastrozole, citrate, acevaltrate, acexamin acid, acifran, acipimox, acita anatibant, anaxirone, anazocine, anazolene, ancarolol, ancit Zanolast, acitemate, acitretin, acivicin, alcantate, aclarubi abine, andolast, androstenediol, androstenedione, andu cin, aclatonium napadisilate, acolbifene, aconiazide, lafungin, anecortave, anetholtrithion, angiotensin amide, aconitine, acotiamide, acoXatrine, acreoZast, acridorex, acri andidoxamine, anidulafungin, anilamate, anilleridine, anilo flavine, acrihellin, acrisorcin, acrivastine, acroinonide, acro pam, anipamil, aniracetam, anirolate, anisacril, anisindione, nine, actaplanin, actarit, actinoquinol, actisolide, actodigin, anisopirol, anisotropine, anisperimus, anitraZafen, anpirto acyclovir, adafenoxate, adamexine, adapalene, adaprolol. line, ansoxetine, antafenite, antazoline, antazonite, anthel adatanserin, adefovir, adekalant, adelmidrol, ademitrionine, mycin, anthralin, anthramycin, antipyrine, antrafenine, apa adenosine, adibendal, adicillin, adimolol, adinazolam, doline, apafant, apalcillin, apaxafylline, apaziquone, adiphenine, aditeren, aditoprim, adosopine, adoZelesin, apaZone, apicycline, aplindore, apomorphine, apovincam adrafinil, adrenalone, adrogolide, afalanine, afeletecan, aflo ine, apraclonidine, apramycin, aprepitant, aprakalim, aprin qualone, afovirsen, afurolol, aganodine, aglepristone, ago dine, aprinocarsine, apofene, aprosulate, aptazapine, apti melatine, aklomide, alacepril, alafosfalin, alagebrium, ala ganel, aptocaine, aranidipine, aranotin, arbaprosil, mecin, alamifovir, alanine, alanosine, alaproclate, arbekacin, arbutamine, arclofenin, ardacin, ardeparin, alatrofloxacin, alazanine triclofenate, albaconazole, arecoline, arfalasin, arfendazam, arformoterol, argatroban, albendazole, albuterol, albutoin, alclofenac, alclometaSone, argimesna, argipressin, argiprestocin, arlidone, arimoclo alcloxa, alcuronium, aldioxa, aldosterone, alemcinal, allen mol, aripiprazole, armodafinil, arnolol, arofylline, artinolol. dronic acid, alentemol, alepride, alestramustine, aletamine, arprinocid, arpromidine, arsanilic acid, arteflene, artemether, alexidine, alexitol, alexomycin, alfacalcidol, alfadex, alfida artemisinin, artemotil, artenimol, artesunate, articaine, artil lone, alfaprostol, alfatradiol, aldaxalone, alfentranil, alflu ide, arundic acid, arZOXifene, ascorbic acid, arsenapine, Zosin, algeldrate, algestone, alibendol, aliconazole, aseripide, asimadoline, asobamast, asocainol, asoprisnil, alifedrine, alifurane, alilusem, alimadol, alinastine, alini aspartame, aspartocin, asperlin, aspirin, aspoxicillin, astemi dine, alipaminde, alliskiren, alitame, alitretinoin, alizapride, Zole, astromicin, asulacrine, atamestane, ataprost, ataqui alletorphine, allobarbitol, allocamide, allocupreide, allom mast, atavanavir, atenolol, atevirdine, atibeprone, atilmotin, ethadione, allopurinol, allylestrenol, allylprodine, almecil atipamezole, atipromod, atiprosin, atizoram, atliprofen, ato lin, almestrone, alminoprofen, almitrine, almokalant, almot calcitol, atolide, atomoxetine, atorvastatin, atosiban, atova riptan, almoxatone, almurtide, alnespirone, alniditan, quone, atracurium, atrasentan, atraleuton, atrimustine, atri alonacic acid, alonimid, aloracetam, alosetron, alovudine, nositol, atromepane, atropine, atropine oxide, auranofin, aloxidone, aloxiprin, aloxistatin, aloZafone, alpertine, alpha aurothioglucose, avanafil, avasimibe, avicatonin, avalamy meprodine, alphamethadol, alphamethyldopa, alphaprodine, cin, aviptadil, avitriptan, avizafone, avobenzone, azoparcin, alpidem, alpiropride, alprafenone, alprazolam, alprenolol. avorelin, avridine, axamozide, axitirome, axomadol, azabon, alprenoXime, alprostadil, alrestatin, altanserin, altapizone, aZabuperone, azacitidine, azacitidine, azaclorzine, azacona alteconazole, althiazide, altinicline, altoqualiine, altreno Zole, azacoSrterol, azacyclonol, aZaftozine, azalanstat, aza gast, altretamine, alvemeline, alverine, alvimopan, alvo lomycin, azaloxan, azamethiphos, azamethonium, azamulin, cidib, amadinone, amafalone, amanozine, amantadine, aZanator, azanidazole, azaperone, azapetine, azaquinzole, amantocillin, ambamustine, ambasilide, ambazone, azaribine, azarole, azaserine, aZasetron, azaspirium, azas ambenonium, ambenoxan, ambomycin, ambrisentan, tene, azatadine, azathioprine, azelaic acid, azelastine, aZelin ambroXol, ambruticin, ambucaine, ambucetamide, ambu nidipine, azepexole, azepindole, azetepa, aZetirelin, azidam phylline, ambuside, ambutonium, amcinafal, amcinafide, fenicol, azidocillin, azimexon, azimilide, azintamide, amcinonide, amdinocillin, amdoxovir, ambucort, amedalin, aZipramide, azithromycin, azlocillin, azlocillin, azolimine, amelometaSone, ameltolide, amelubant, ameSergide, amet aZosemide, aztomycin, aztreonam, aZumolene, bacampicil antrone, amethocaine, ameZapine, ameZinium, amfenac, lin, bacitracin, baclofen, bacmecillinam, bakeprofen, bala amfepentorex, amfetaminil, amflutizole, amfonelic, amicar glitaZone, balaZipone, balofloxacin, balsalazide, bamalu balide, amicloral, amicycline, anidantel, amidapsone, Zole, bamaquimast, bambermycin, bambuterol, bamethan, amidephrine, amiflamine, amifloverine, amifloxacin, ami bamifylline, bamipine, bamirastine, bamidazole, banox fostine, amiglumide, amikacin, amikhelline, amiloride, antrone, baduiloprim, barbexaclone, barbital, barixibat, bar amiloxate, aminacrine, amindocate, amineptine, aminoglu mastine, barnidipine, barucainide, barusiban, basifungin, tethimide, aminohippuric acid, aminolevulinic acid, ami batalbulin, batanopride, batebulast, batelapine, batilol, bati nometradine, aminopentamide, aminophenaZone, amino mastat, batoprozine, baxitoizine, baZedoxifene, bazinaprine, phylline, aminopromazine, aminopterin, aminopyrine, becanthone, becatecarin, becliparcil, beclamide, beclicona aminoquinol, aminoquinuride, aminorex, aminosalicylic Zole, beclobrate, beclomethasone, beclotiamine, befetupi acid, aminothiazole, amiodarone, amiperone, amphenazole, tant, befiperide, befloxatone, befunolol, befuraline, bekana amipizone, amiprolose, amiquinsin, amisometradine, mycin, belaperidone, belarizine, belfosdil, belotecan, amisulprode, amiterol, amithioZone, amitivir, amitraz, ami beloxamide, beloxepin, bemarinone, bemegride, triptyline, amitriptyinoxide, amiXetrine, amlexanoX, amlin bemesetron, bemetizide, beminafil, bemiparin, bemetradine, tide, amlodipine, amocarzine, amodiaquine, amolanone, bemoradan, bemotrizinol, benactyzine, benafentrine, amonafide, amoproxan, amopyroquine, amorolfine, amos benapry Zine, benaxibine, benazepril, bencianol, bencisteine, canate, amosulatol, amotoSalen, amotriphene, amoxapine, benclonidine, bencyclane, bendacalol, bendamustine, US 2007/01 16729 A1 May 24, 2007 24 bendazac, bendazol, benderizine, bendroflumethazide, line, bullaquine, bumadizone, bumecaine, bumepidil, bumet benethamine penicillin, benexate, benfluorex, benfosformin, anide, bumetriazole, bunaftine, bunamidine, bunamiodyl, benfotiamine, benflurodil, benhepazone, benidipine, ben bunaprolast, bunaZosin, bunitrolol, bunolol, buparvaquone, moxin, benolizime, benorilate, benorterone, benoxifos, bupicomide, bupivacaine, bupranolol, buprenorphine, benoxaprofen, benoximate, benpenolisin, benperidol, ben bupropion, buquinerin, buquinolate, buquiterine, buramate, properine, benrixate, bensalan, benserazide, benSuldazic burodiline, buserelin, buspirone, busulfan, butobarbital, acid, bentazepam, bentemazole, bentiamine, bentipimine, butacaine, butacetin, butaclamol, butadiaZamide, butafos bentiromide, bentoquatam, benurestat, benzalkonium, ben fan, butalamine, butalbital, butamben, butamirate, butami Zarone, benzbromarone, benzestrol, benzethidine, benzetho sole, butamoxane, butanilicaine, butanserin, butantrone, nium, benzetimide, benzilonium, benzindopyrine, benzio butaperazine, butaprost, butaverine, butedronate, bytenafine, darone, benzmalecene, benznidazole, benzobarbital, buterizine, butenamate, buthiazide, butibufen, butifrine, benzocaine, benzoclidine, benzoctamine, benzodepa, ben butikacin, butilfenin, butinazocine, butinoline, butirosin, Zododecinium, benzonatate, benzopyrronium, benzo butixirate, butixocort, butobendine, butoconazole, quinonium, benzotript, benzoxiquine, benzoxonium, ben butocrolol, butoctamide, butofiolol, butonate, butopamine, Zoylpas, benzphetamine, benZpiperylon, benzpyrinium, butopiprine, butoprozine, butopyrammonium, butorphanol, benzquercin, benzquinamide, benzthiazide, benztropine, butoxamine, butoxylate, butriptyline, butropium, butylsco benzydamine, benzylhydrochlorothiazide, benzylpenicillin, polamine, butynamine, buZepide, cabastine, cabergoline, benzylsulfamide, bepafant, beperidium, bephenium, bepias cactinomycin, cadralazine, cadrofloxacin, cafaminol, tine, bepridil, beractant, beraprost, berberine, berefrine, ber cafedrine, caffeine, calcifediol, calciprotriene, calcitriol, cal genin, berlafenone, bermoprofen, bertosamil, berupipam, cobutrol, caldaret, caldiamine, caloxetic acid, calteridol. bervastatin, berythromycin, besigomsin, besipirdine, beson clausterone, camazepam, cambendazole, camaglibose, cam prodil, besulpamide, besunide, beta carotene, betacetylmeth iverine, camptothecin and its analogues such as 9-amino adol, betahistine, betaine, betameprodine, betamethadol, camptothecin, 10-hydroxy camptothecin, 7-ethyl-10-hy betamethasone, betamicin, betamipron, betaprodine, betax droxy camptothecin, 9-nitro camptothecin and all other olol, betazole, bethanacol, bethanidine, betiatide, betox camptothecin analogues with six, seven and eight membered ycaine, bevantolol, bevonium, beXarotene, bexlosteride, lactone rings, camonagrel, camo.stat, camylofin, canbisol, bezafibrate, beztiramide, bialamicol, biapenem, bibeZonium, candesartan, candicidin, candocuronium, candoXatril, can bibrocathol, bilcalutamide, bici fadine, bicoldil, biclofibrate, doXatrilat, canertinib, canfosfaminde, cangrelor, cannabinol, biclotymol, bicozamycin, bidimazium, bidisomide, can renoate, can renone, capectitabine, capobenate, capobe bietamiverine, bietaserpine, bifemelane, bifepramide, nic acid, capravirine, capreomycin, capromorelin, caproX bifeprofen, bifeprunox, bifluranol, bifonazole, bilastine, amine, capsaicin, captamine, captodiame, captopril, capu bimakalim, bimatoprost, bimoclomol, bimosiamose, bin ride, carabersat, caracemide, carafiban, caramiphen, darit, binedaline, binfloxacin, binfibrate, biniramycin, bini carbachol, carbadox, carbamazepine, carbentel, carbasone, Zolast, binodenosine, binospirone, bioallethrin, botin, bipe carbaspirin, carbazeran, carbazochrome, carbazocine, cabe namol, biperiden, biphenamine, biricodar, biriperone, nicillin, carbenoXolone, carbenzide, carbetapentane, carbe bisacodyl, bisantrene, bisaramil, bisbendazole, bisben tocin, carbidopa, carbimazole, carbinoxamine, carbiphene, tiamine, bisbutiamine, bisdequilinium, bisfenaZone, bisfen carbofenotion, carboplatin, carboprost, carboquone, car tidine, bisnafide, bisorbin, bisoctriazole, bisoprolol, bisorcic, bubarb, carburazepam, carbutamide, carbuterol, carcainium, bisoxatin, bispyrithione, bithonol, bithionoloxide, butipa carebastine, carfentanil, carfimate, cargutocin, cariporide, Zone, bitolterol, bitoscanate, bivalirudin, bizelesin, bleomy carisoprodol, carmantadine, carmofur, carmoterol, carmus cin, blonanserine, bluenSomycin, bofumustine, bolandiol. tine, carnidazole, carnitine, carocainide, caroverine, caroX bolasterone, bolazine, boldenone, bolenol, bolmantalate, aZone, carperidine, carperitide, carperone, carphenazine, bometolol, bopindolol, bornaprine, bornaprolol, borelone, carpindolol, carpipramine, carpraZidil, carprofen, capro borocaptaine, bortezomib, bosentan, botiacrine, boxidine, nium, carsalam, carsatirin, cartasteine, cartaZolate, carteolol. brallobarbital, brasofensine, brazergoline, brefonalol, carubicin, carumonam, carvedilol, carvotroline, carZelesin, bremazocine, brequinar, bretazenil, bretyllium, brifentanil, carzenide, casanthranol, casokefaminde, caspofungin, brimonidine, brinaZaprone, brindoXime, brinzolamide, cathine, cathinone, cebaracetam, cedefingol, cefaclor, brivudine, brobactam, broclepride, brocrestine, brocrinat, cefadroxil, cefalonium, cefaloram, cefamandole, cefaparole, brodimoprim, brofaromine, brofoxine, brolaconazole, bro cefatriazine, cefazaflur, cefaZedone, cefazolin, cefbupera lamfetamine, bromadoline, bromamid, bromazepam, bro Zone, cefanel, cefcapene, cefclidin, cefdaloXime, cefdinir, mchlorenone, bromebric acid, bromerguride, bromete cefditoren, cefedrolor, cefempidone, cefepime, cefetamet, namine, bromfenac, brom hexene, bomindione, cefetecol, cefetriaole, cefivtril, cefixime, cefimatilen, cef bromisovalum, bromociclen, bromocriptine, bromodiphe menoxine, cefimepidium, cefimetazole, ceminox, cefodizime, nylhydramine, bromofenfos, bromofos, bromopride, bro cefonicid, cefoperaZone, ceforanide, cefoselis, cefotaxime, moxanide, bromperidol, brompheniramine, broparestrol, cefotetan, cefotiam, cefoVecin, cefoxazole, cofoxitin, cefo broperamol, bropirimine, broquinaldol, broSotaminde, broS Zopran, cefpimizole, ce?piramide, cefpodoxime, cefprozil, tallicin, broSuximide, brotianide, brotizolam, brovanexine, cefauinome, cefrotil, cefroxadine, cefsulodin, cefsumide, brovincamine, broxaldine, broXaterol, broxitalamide, broXu ceftazidime, cefteram, ceftezole, ceftibuten, ceftioflur, cefti ridine, broxyquinoline, bucainide, bucetin, buciclovir, buci olene, ceftioxide, ceftioxime, ceftriaxone, cefuracetamime, llamine, bucindolol, bucladesine, buclizine, buclosaminde, cefuroxime, cefuZonam, celecoxib, celgosivir, celiprolol. bucloxic acid, bucolme, bucricaine, bucromarone, bucu cemadotin, cephacetrile, cephadrine, cephalexin, cepha molol, budesonide, budipine, budotitane, budralazine, loglycin. Cephaloridine, cephalothin, cephapirin, cepharan bufenadrine, bufeniode, bufetolol, bufexamac, bufezolac, thine, cephradine, cericlamine, cerivastatin, ceronapril, buflomedil, bufogentin, buformin, bufrolin, bufuralol, bufyl ceruletide, cetaben, cetalkonium, cetamolol, cetefloxacin, US 2007/01 16729 A1 May 24, 2007

cethexonium, cethromycin, cetiedil, cetilistat, cetirizine, clonixeril, clonixin, clopamide, clopenthixol, cloperastine, cetocycline, cetopheincol, cetotiamine, cetoxime, cetraxate, cloperidone, clopidogrel, clopidol, clopimozide, clopipazan, cetrimonium, cetylpyridinium, cevimeline, chaulmosulfone, clopirac, cloponone, cloprendol, cloprostenol, cloprothiaz chenodiol, chinofon, chlofibrate, chlophendianol, chlo ole, cloquinate, cloquinozine, cloracetadol, cloranolol, clo racyZine, chloralose, chlorambusil, chloramines-T, chloram razepate, cloraZepic acid, clorethane, chlorexolone, clorfen phenicol, chlorazanil, chlorbenoxamine, chlorbetamide, Vinos, clorgiline, cloricromen, cloridarol, clorindanic acid, chlorcyclizine, chlordantoin, chlordiazepoxide, chlordimo clorindione, clormecaine, cloroperone, clorophene, cloro rine, chlorhexidine, chlorindanol, chlorisondamine, qualone, clorotepine, clorprenaline, clorSulon, clortermine, chloramadione, chlormerodrin, chlormeZanone, chlormida closantel, closiramine, clostebol, clothiapine, clothixamide, Zole, chlornaphazine, chloroaZodin, chloroprednisone, chlo clotiazepam, cloticasone, clotioxone, clotixamide, clotrima roprocaine, chloropyramine, chloroquine, chloroserpidine, Zole, clovoxamine, cloxacepride, cloxacillin, cloxazolam, chlorothen, chlorothiazide, chlorotrianisene, chloroxine, cloxestradiol, cloximate, cloxotestosterone, cloxypendyl. chloroxylenol, chlorphenesin, chlorpheniramine, chlorphe cloxyquin, clozapine, cobalamide, cocaine, codeine, noctium, chlorphenoxamine, chlorphentermine, chlorproet codoxime, cofistatin, cogaZocine, colchicines, colestolone, hazine, chlorproguanil, chlorpromazine, chlorpropamide, colfenamate, colforsin, colfosceril, colimecycline, colterol, chlorprothixene, chlorpyrifos, chlortetracycline, chlorthali coluracetam, conessine, congaZone, conivaptan, conor done, chlorthenoxazine, chlorZoxazone, cholecalciferol, phone, cormethasone, corticorelin, cortisone, cortisuZol. cholesterol, choline alfoscerate, choline, chromic chloride, cortivaZol, cortodoxone, cotinine, cotriptyline, coumaphos, chromonar, ciadox, ciaftalan, ciamexon, cianergoline, cian coumazolin, coumermycin, coumetarol, creatinine, creati idanol, cianopramine, ciapilome, cicaprost, cicarperone, nolfosfate, cresotamide, cridanimod, crilvastin, crisinatol, ciclactate, ciclafrine, ciclaZindol, ciclesonide, cleletanine, crobenetine, croconazole, cromakalim, cromitrile, cromogli cicliomenol, ciclonicate, ciclonium, ciclopiroX, ciclo cate lisetil, cromolyn, crolom, cronidipine, cropropamide, pramine, cicloprofen, cicloprolol, ciclosidomine, cicloti crotamiton, crotetamide, crotoniazide, crotoxyfos, crufo Zolam, ciclotropium, cicloxilic acid, cicloxolone, cicor mate, cuprimyxin, cuproXoline, cyacetacide, cyamemazine, tonide, cidofovir, cidoxepin, cifenline, cifostodine, cyanocobalamine, cyclacillin, cyclamate, cyclamic acid, ciglitaZone, ciheptolane, ciladopa, cilansertron, cilastatin, cyclandelate, cyclarbamate, cyclazocine, cyclazodone, cilaZapril, cilengitide, cilexin, cilnidipine, cilobamine, cilo cyclexanone, cyclindole, cycliramine, cyclizine, cyclobar bradine, cillofungin, cilomilast, cilostamide, ciloStaZol, cilu bital, cyclobendazole, cyclobenzaprine, cyclobutoic acid, previr, cilutazoline, cimaterol, cimemoxin, cimetidine, cyclobutyrol, cyclocumarol, cyclofenil, cycloguanil, cyclo cimetropium, cimicoxib, cimoxatone, cinacalcet, cinalukast, heximide, cyclomenol, cyclomethycaine, cyclopentamine, cinametic acid, cinamolol, cinanserin, cinaproxen, cin cyclopenthiazide, cyclopentolate, cyclophenazine, cyclo chophen, cinecromen, cinepazet, cinepazide, cinfenine, cin phosphamide, cyclopregnol, cyclopyrronium, cycloserine, fenoac, cinflumide, cingestol, cinitapride, cinmetacin, cin cyclothiazide, cyclovalone, cycotiamine, cycrimine, namaverine, cinnamedrine, cinnarizine, cinnofuradione, cyfluthrin, cyhalothrin, cyheptamide, cyheptropine, cinoctramide, cinodine, cinolazepam, cinoquidox, cinoxa cynarine, cypenamine, cypermethrin, cypothrin, cin, cinoxate, cinoXolone, cinoXopazide, cinperene, cinpra cyprazepam, cyprenorphine, cyprodenate, cyproheptadine, Zole, cinpropazide, cinpromide, cintaZone, cintriamide, cyprolidol, cyproduinate, cyproterone, cyproximide, cyro cinuperone, cioteronel, cipamfylline, cipemastat, ciprafa mazine, cysteamine, cysteine, cystine, cytarabine, cythi mide, cipralisant, cipraZafone, ciprefadol, ciprocinonide, olate, dabelotine, dabigatran, dabuZalgron, dacarbazine, ciprofibrate, ciprofloxacin, ciprokiren, cipropride, ciprocqua dacemazine, dacinostat, dacisteine, dacopafant, dactinomy Zone, ciprestene, ciramadol, cirazoline, cirolemycin, cin, dacuronium, dagapamil, dagluril, dalbavancin, dal cisapride, cisatracurium, cinconazole, cismadinone, cispl braminol, dalcotidine, daledalin, dalfopristin, dalteparin, atin, cistinexine, citalopram, citatepine, citenamide, citena daltroban, dalvastatin, dametralast, damotepine, danazol. Zone, citicoline, citiolone, cizolirtine, cladribine, clamidoxic daniquidone, danittracen, danofloxacin, danosteine, dan acid, clamikalant, clamoxyquin, clanfenur, clanobutin, clan thron, dantrolene, dapiprazole, dapitant, dapivirine, dapoX tifen, clarithromycin, clavulanate, claZolam, clazolimine, etine, dapsone, daptomycin, darbufelone, darenzepine, dar claZuril, clebopride, clefamide, clemastine, clemeprol, glitaZone, darifenacin, darodipine, darunavir, darusentan, clemizole, clenbuterol, clempirin, clentiazem, cletoquine, dasantafil, datelliptium, daunorubicin, daxalipram, daZadrol, clevidipine, clevudine, clibucaine, clidafidine, clidanac, dazepinil, dazidamine, daZmegrel, dazolicine, dazopride, clindium, climaZolam, climbazole, climiqualine, clinafloxa daZoquinast, daZOXiben, deboxament, debrisoquin, decame cin, clindamycin, clinofibrate, clinolamide, climprost, clio thonium, decimemide, decitabine, decitropine, declenper quinol, clioxanide, cliprofen, cliropamine, clobazam, one, declopramide, decloxizine, decominol, decoquinate, clobenoside, clobenzepam, clobenorex, clobenztropine, clo dectaflur, deditonium, deferasirox, deferiprone, deferoxam betasol, clobetaSone, clobutinol, clobuZarit, clocanfamide, ine, deflazacort, defosfamine, defoslimod, degarelix, dehy clocapramine, clociguanil, clocinizine, clocortolone, clo droacetic acid, dehydrocholic acid, dehydroemetine, coumarol, clodacaine, clodanolene, clodazon, clodoxopone, delanterone, delapril, delavirdine, delquamine, deergotrile, clodronate, clofarabine, clofazimine, clofenamic acid, delfantrine, delfaprazine, Selmadinone, delmetacin, delimpi clofeniclan, clofenetamine, clofenoxyde, clofevine, clofex nol, delorazepam, deloxolone, delprostenate, delucemine, amine, clofeZone, clofibrate, clofibric acid, clofibride, clo dembrexine, demecarium, demeclocycline, demecolcine, filium, clofucarba, clofoctol, cloforex, clofurac, clogestone, demecycline, demegestone, demelverine, demexiptiline, cloguanamil, clomacrin, clomegestone, clometacin, clom democonazole, demoxepam, demoxytocin, denatonium, etherone, clomethiazole, clometocillin, clomifenoxide, clo denaverine, denbufylline, denipride, denofungin, denopam minorex, clomiphene, clomipramine, clomocycline, clo ine, denotivir, denpidazone, denufosol, denZimol, depe moxir, clonazepam, clonazoline, clonidine, clonitazine, lestat, depramine, depreotide, deprodone, deprostil, dep US 2007/01 16729 A1 May 24, 2007 26 tropine, dequalinium, deracoxib, deramciclane, deriglidole, fene, diprogulic acid, diproleandomycin, diprofylline, dip derpanicaine, derSalazine, desapidin, desciclovir, descino roqualone, diproteverine, diprotrizoate, diproxadol, dipy lone, deserpidine, desipramine, deeslanoside, desloratidine, ridamole, dipyrithione, dipyrocetyl, dipyrone, diduafosol, deslorelin, desmeninol, desmethylmoramide, desmopressin, dirithomycin, dirlotapide, disermolide, disquonium, disob desocriptine, desogestrel, desmorphine, desonide, des utamide, Sidofenin, Sdisogluside, disopyramide, disoxaril. Oximetasone, desoxycorticosterone, desvenlafaxine, detaj distigmine, disufenton, disulergine, disulfamide, disulfiram, mium, detanosal, deterenol, detirelix, detiviciclovir, detro disupraZoole, ditazole, ditekiren, ditercalinium, dithiaanine, midine, detorubicin, detrothyronine, devapamil, devaZepide, ditiocade, ditiocarb, ditiomustane, ditolamide, ditophal, div dexamethasone, dexamisole, dexbrompheniramine, dex abuterol, divalproex, divaplon, dixanthogen, dizatrifone, budesonide, dexchlorpheniramine, dexclamol, dexecadotril, dizcilpine, dobesilate, dobupride, dobutamide, dobutamine, dexefaroxan, dexetimide, dexetoZoline, dexfenfluramine, docarpamine, docebenone, docetaxel, doconazole, doconex dexfosfoserine, dexibuprofen, deximafen, dexindoprofen, ent, docosanol, docusate, dodeclonium, dodicin, dofamium, dexivacaine, dexketoprofen, dexlofexidine, dexloxiglumide, dofecquidar, dolfetilide, dolasetron, doliracetam, domaZoline, dexmedetomidine, dexmethylphenidate, dexnafenodonee, domiodol, domiphen, domipizone, domitroban, domopred dexniguldipine, dexnorgestrel, dexormaplatin, deXOXadrol, nate, domoxin, domperidone, donepezil, donetidine, doni dexpanthenol, dexpemedolac, dexpropranolol, dex.proxib triptan, dopamantine, dopamine, dopexamine, dopropidil, utene, dexraZOxane, dexsecoverine, deXSotalol, dextilidine, doqualast, dorampimod, doramectin, doranidazole, doras dextiopronin, dextofisopam, dextroamphetamine, dextro tine, Soreptide, doretinel, doripenem, dorZolamide. dosergo femine, dextromethorphan, dextromoramide, dextrorphan, side, doSmalfate, dotarizine, dotefonium, dothiepin, doxa dextrothyroxine, dexcerapimil, Sezaguanine, dezinamide, curium, doxapram, doxaprost, doxazosin, doxefazepam, dezocine, diacerein, diacetamate, diacetolol, diamfenetide, doxenitoin, doxepine, doxergocalciferol, doxibetasol, doxi diamocaine, diampromide, diamthiazole, diapamide, diar fluridine, doxofylline, doxorubicin, doxpicomine, doxycy barone, diathymosulfone, diatrizoate, diaveridine, diaz cline, doxylamine, draflazine, dramedilol, draquinolo, drazi epam, diaziquone, diazoxide, dibekacin, dibemethine, dox, dribendazolew, drimidene, drobuline, drocinonide, dibenzepin, dibenzothiophene, dibrompropamidine, bibro droclidinium, drofenine, droloxifene, drometrizole, dromo msalan, dibrospidium, dibucaine, dibuprol, dibupyrone, stanolone, dronabinol, drinedarone, dropempine, droperidol. dibusadol, dicarbine, dicarfen, dichloralphenaZone, droprenilamine, dropropizine, drospirenone, drotaverine, dichloramine, dichlorisone, dichlormeZanone, dichlorophen, drotebanol, droxacin, droXicainide, droxicam, droxidopa, dichlorphenarsine, dichloroxylenol, dichlorphenamide, droximavir, droxypropine, duazomycin, dulofibrate, dulox dichlovos, diciferron, dicirenone, diclaZuril, diclofenac, etine, duloZafone, dumorelin, dumetacin, duoperone, diclofenamide, diclofensine, diclofutrime, diclometide, dupracetam, dutasteride, dyclonine, dyhydrogestrone, diclonixin, dicloralurea, dicloxacillin, diclolinium, dicum dymanthine, dyphylline, ebalZotan, ebastine, eberconazole, rol, dicyclomine, didanosine, didrovaltrate, dieldrin, dienes ebiratide, ebrotidine, ebselen, ecabapide, ecabet, ecadotril, trol, dienogest, diethadione, diethylphthalate, diethylcar ecalcidene, ecamsule, ecastolol. ecenofloxacin, bamazine, dietylpropion, diethylstilbestrol, echothiophate, ecipramidil, eclanamine, eclaZolast, ecomus dethylthambutene, dietyltoluamide, dietifen, difebarbamate, tine, econazole, ecopipam, ecraprost, ectylurea, edaglita difemerine, difemetorex, difenamizole, difencloxazine, Zone, edaravone, edatrexate, edelfosine, edetol, edifolone, difenoximide, difenoxin, difetarsone, difeterol, diflomote edogestrone, edonentan, edotecarin, edotreotide, edoxudine, can, diflorasone, difloxacin, difluanine, diflucortolone, diflu edratide, edronocaine, edrophonium, efaproxiral, efaroxan, midone, diflunisal, difluprednate, diftalone, digitalis, digi efavirenz, efegatran, efepristin, efetozole, efletirizine, eflo toxin, digoxin, dihexyverine, dihydralazine, rnithine, efloxate, eflucimibe, elfiumast, efonidipine, efroto dihydrocodeine, dihydroergotamine, dihydrostreptomycin, mycin, eganoprost, eglumetad, egtazic acid, equalen, elac dihydrotachysterol, diisobutylaminobenzoyloxypropyl theo ridar, elantrine, elanzepine, elaarofiban, elbanizine, phylline, diisopromine, diisopropanolamine, diisopropy eldacimibe, eletriptan, elfazepam, elgotipine, elinafide, elip lamine, dilaZep, dilevalol, dilmefone, diloxanide, diltiazem, rodil, elisartan, ellagic acid, elliptinium, elmustine, elnad dimabefylline, dimadectin, dimecamine, dimeclonium, ipine, elopiprazole, elsamitrucin, eltanolone, eltenac, elto dimecrotic acid, dimefadane, dimefline, dimelazine, dimen prazine, elucaine, elvucitabine, elzasonan, elziverine, hydrinate, dimenoxadol, dimepheptanol, dimepranol, dime emakalim, emapunil, embramine, embusartan, embutra pregnen, dimepropion, dimeproZan, dimeSna, dimesone, mide, emedastine, emepronium, emetime, emeglitate, emi dimetacrine, dimetamfetamine, dimethadione, dimethazan, lium, emiteflur, emiverine, emodepside, emopamil, emorfa dimethisoquin, dimethisterone, dimetholizine, dimetho Zone, emitricitabine, emylcamate, enadoline, enalapril, thizine, dimethoxanate, dimethylaminoethyl reserpilinate, enalaprilat, enalkiren, enaZadrem, enbucrilate, encainide, dimethylthambutene, dimethyltubocurarinium, enciprazine, enclomiphene, encyprate, endixaprine, endo dimetipirium, dimetofrine, dimetridazole, diminaZene, mide, endralazine, endrysone, enecadin, enefexine, enest dimiracetam, dimoxamine, dimoxaprost, dimoxyline, ebol, enfenamic acid, enfluvirtide, englitaZone, eniclobrate, dimpylate, dinaline, dinaZafone, diniprofylline, dinitolmide, enilconazole, eniloSpirone, eniluracil, eniporide, enisoprost, dinoprost, dinoprostone, dinsed, diohippuric acid, dioSmin, enloplatin, enocitabine, enofelast, enolicam, enoxacin, diotyrosine, dioxadrol, dioxamate, dioxaphetyl butyrate, enoxamast, enoxaparin, enoXimone, enoXolone, enipipra dioxation, dioxethedrin, dioxifedrine, dioxybenaZone, Zole, empiroline, enprazepine, enprofylline, enpromate, dioxyline, dipenine, diperodon, diphemanil, diphenadione, enprostil, enramycin, enrasentan, enrofloxacin, ensacillin, diphenan, diphenchloxazine, diphenhydramine, diphenidol. ensulizole, entacapone, entecavir, entSufon, enviomycin, diphenoxylate, diphenylpiperidinomethyldioxolan, diphe enviradene, enviroxime, enZacamene, anZastaurin, epalr nylpyraline, diphenoxazide, dipipanone, dipiproverine, estat, epanolol, eperezolid, eperisone, epervudine, ephe dipivefrin, diprafenone, diprenorphine, diprobutine, dipro drine, epicainide, epicillin, epicriptine, epiestriol, US 2007/01 16729 A1 May 24, 2007 27 epimestrol, epinastine, epinephrine, epinepheryl, epipropi fenozolone, fenpentadiol, femperate, fenprpalone, fenpipra dine, epirizole, apiroprim, epirubicin, epitetracycline, epi mide, fenpiprane, fempiverinium, fenprinast, fenproporex, thiazide, epitioStanol, eplerenone, elivanserin, epoprostenol, fenprostalene, fenduiaone, fenretinide, fenspiride, fentanyl. epostane, eprazinone, eprinomectin, epristeride, eprobe fenthion, fentiazac, fenticlor, fenticonazolem, fentonium, mide, eprosartan, eprovafen, eproxindine, eproZinol, fenvalerate, fenyripol, fepentolic acid, fepitrizol, fepradinol, epsipranel, epaloprost, eptapirone, eptaplatin, eptastigmine, feprazone, fepromide, feprosidinine, ferpifosate, fesoterod eptazocin, eptifibatide, equillin, erbuloZole, erdosteine, ine, fetoxylate, fexicaine, fexinidazole, fexofenadine, feza ergocalciferol, ergonovine, ergotamine, eritoran, erizepine, tione, fezolamine, fiacitabine, fialuridine, fibracillin, fidar erlotinib, ercainide, ersentilide, ertapenem, ertiprotafib, estat, fidexaban, fiduXosin, figopitant, filaminast, filenadol, erythrity tetrnitrate, erythromycin, esafloxacin, esaprazole, filipin, finafloxacin, finasteride, fingolimod, fipamezole, esatenolol, escitalopram, esculamine, eseridine, esflurbipro fipexide, fipronil, firocoxib, flavamine, flavodic acid, fla fen, esketamine, escarbazepine, esmolol, esomeprazole, eso vodilol, flavoxate, flazalone, flecainide, flerobuterol, narimod, esorubicin, esoxybutynin, espatropate, esproquin, fleroxacin, flesinoxan, flestolol, fletazepam, flezelastine, fli estazolam, estradiol, estramustine, estraZinol, estriol, estro banserin, flindokalner, flocalcitriol, floctafenine, flomoxef, furate, estrone, estropipaten esupone, esZopclone, etaben floptopione, florantyrone, flordipine, floredil, florfenicol, Zarone, etacepride, etafedrine, etafenone, etalocib, florifenine, flosatidil, flosequinan, flosulide, flotrenizine, etamestrol, etaminile, etamiphylline, etamocycline, etanida floverine, floxacillin, floxacrine, floxuridine, flucizine, flu Zole, etanterol, etaqualone, etarotene, etasuline, etazepine, alamine, fluanisone, fluazacort, fluaZuron, flubanilate, etazolate, etebenecid, eterobarb, etersalate, ethacridine, flubendazole, flubepride, flucarbril, flucetorex, flucindole, ethacrynic acid, ehtambutol, ethamivan, ethamsylate, ethav flucinprazine, flucloronide, fluconazole, flucrylate, flucy erine, ethenZameide, ethiazide, ethinamate, ethinyl estradiol. tosine, fludalanine, fludarabine, fludazonium, fludeoxyglu ethionamide, ethisterone, ethoheptazine, ethomoxane, etho cose, fludiazepam, fludorex, fludoxopone, fludrocortisone, nam, ethopabate, ethopropazine, ethoSuximide, ethotoin, flufenamic acid, flufenisal, flufosal, flufylline, flugestone, ethoxazene, ethoxazorutoside, ethoXZolamide, ethybenz fluindarol, fluindione, flumazenil, flimecinol, flumedroxone, tropine, ethyl biscoumacetate, ethyl carfluZepate, ethyl car flumequine, flumeridone, flumethasone, flumethiazole, flu trizoate, ethyl dibunate, ethyl dirazepate, ethyl loflazepate, metramide, flumexadol, flumeZapine, fluminorex, flumizole, ethylestrenol, ethylhydrocupreine, ethylmethylthiambutene, flumoxonide, flunamine, flunarizine, flunidazole, ethylmorphine, ethylnorepinepherine, ethylstilbamine, eth flunisolide, flunitrazepam, flunixin, flunoprost, flunoxapro ylnerone, ethylnodil, ethypicone, etibendazole, eticlopride, fen, fluocinolone, fluocinonide, fluocortin butyl, fluocor eticyclidine, etidocaine, etidronate, etidronic acid, etifelm tolone, fluorescein, fluoresone, fluorodopa, fluo ine, etifenin, etifoxine, etilamfetamine, etillefrine, eti rometholone, fluorosalan, fluorouracil, fluotracen, levodopa, etinidine, etipirium, etiprendol, etiproston, etirac fluoxetine, fluoxymesterone, fluparoxan, flupentiXol, flu etam, etiroXate, etisazole, etisomicin, etisulergine, etizolam, peramide, fluperlapine, fluperolone, flupheazine, flupi etocarlide, etocrylene, etodolac, etodroxizine, etofamide, mazine, flupirtine, flupranone, fluprazine, fluprednidene, etofenamate, etofemproX, etofibrate, etofermin, etofuradine, fluprednisolone, fluprofen, fluprofylline, fluproduaZone, flu etofylline, etoglucid, eorolex, etolotifen, etoloxamine, eto prostenol, fluguaZone, fluradoline, flurandrenolide, flurantel, midate, etomidoline, etomoxir, etomitaZene, etonogestrel, flurazepam, flurbiprofen, fluretofen, flurithromycin, fluroc etoperidone, etoposide, etoprindole, etoprine, etoricoxib, itabine, flurofamide, flurogestone, flusoxolol, fluspiperone, etorphine, etosalamide, etoxadrol, etoxeridine, etoZolin, fluspirilene, flutamide, flutazolam, flutemazepam, flutiazin, etrabamine, etravirine, etretinate, etriciguat, etryptamine, fluticasone, flutizenol, flutomidate, flutonidine, fluto etymemazine, eucaine, eucalyptol, eugenol, euprocin, evan prazepam, flutrimazole, flutroline, flutropium, fluvastatin, damine, evernimicin, everolimus, evicromil, exalamide, fluvoxamine, fluzinamide, fluZoperine, fodipir, folic acid, exametazime, examorelin, exaprolol, exatecan, exemestane, fomepizole, fomidacillin, fominoben, fomiversen, exepanol, exifone, exiprofen, exisulind, eZetimibe, eZlopi fomocaine, fonazine, fondaparinux, fopiirtoline, forasartan, tant, fadolmidine, fadrozole, falecalcitriol, fallintolol, falli forfenimex, formebolone, formestane, formetorex, formini pamil, falnidamol, famciclovir, famirapinium, famotidine, trazole, formocortal, formoterol, forodesine, foropafant, fos famotine, fampiridine, famprofaZone, fampronil, fananserin, amprenavir, fosarilate, fosazepam, foSenazide, fosflucona fanapanel, fandofloxacin, fandoSentan, fanetizole, fantofar Zole, fosfocreatinine, fosfomycin, foSfonet, fosfosal, one, fantridone, fargilitazar, fasidotril, fasiplon, fasoracetam, fosfructose, fosinopril, fosinoprilat, foSmenic acid, foSmi faudil, fazadinium, fazarabine, febantel, febarbamate, febu domycin, fosopamine, fosphenyloin, fospirate, fosquidone, prol, febuverine, febuxostat, feclemine, feclobuzone, fedot fostedil, foSrtriecin, fosveset, fotemustine, fortrenamine, ozine, fedrilate, felbamate, felbinac, felipyrine, felodipine, fozivudine, frabuprofen, fradafiban, frakefamide, framyce feloprentan, fely pressin, femoxetine, fenabutene, fenace tin, frentizole, freselestat, fronepidil, fropenem, froVatriptan, tinol, fenaclon, fenadiazole, fenaftic acid, femalamide, froxiprost, ftaxilide, ftivazide, formetazine, forpropazine, femalcomine, fenamifuril, fenamole, fenaperone, fenbenda fubrogonium, fudosteine, fuladectin, fulvestrant, fumagillin, Zole, fenbenicillin, fenbufen, fenbutreazate, fencamfamin, fumoxicillin, fungimycin, fuprazole, furacrinic acid, furafyl fencibutirol, fenclexonium, fleclofenac, fenclonine, fenclo line, furalazine, furaltadone, furaprofen, furazabol, furazoli rac, fenclozic acid, fendiline, fendizoate, fendosal, fener done, furazolium, furbicillin, furcloprofen, furegrelate, fure itrol, fenestrel, fenethazine, fenethylline, fenetradil, fenflu thidine, furfenorex, furidarone, furmethoxadone, mizole, fenfluramine, flenfluthrin, fengabine, fenharmane, furnidipine, furobufen, furodazole, furofenac, furomazine, fenimide, feniodium, fenipentol, fenirfibrate, fenisorex, furomine, furosemide, furostilbestrol, fursalan, fursul fenitrothion, fenleuton, fenmetozole, fenmetraminde, tiamine, furterene, furtrethonium, fusafungine, fusidate, fenobam, fenocinol, fenocitimine, fenofibrate, fenoldopam, fusidic acid, fuzlocillin, gabapentin, gabapexate, gaboxadol, fenoprofen, fenoterol, fenoerine, fenoxazoline, fenoxedil, gacyclidine, gadobenate, gadobutrol, gadocollectic acid, US 2007/01 16729 A1 May 24, 2007 28 gadodiamine, gadofosveset, gadomelitol, gadopenamide, ifoxetine, iganidipine, igmesine, iguratimod, ilaprazole, ila gadopentetate, gadoteric acid, gadoteridol, gadoverseta treotide, ilepcimide, iliparcil, ilmofosine, illoomastat, mide, gadoxetate, gadoxeticaicid, galamustine, galntamine, ilonidap, illoperidone, imafen, imanixil, imatinib, imaZodan, galarubicin, galasomite, galdansetron, gallamine triethio imcarbofos, imiclopazine, imidafenacin, imidapril, imidap dide, gallopamil, galocitabine, galosemide, galtifenin, gam rilat, imidocarb, imidoline, imidurea, imiglitazar, imiloxan, fexine, gamolenic acid, gamaXolone, ganciclovir, ganefro iminophenimide, imipenem, imipramine, imipraminoxide, mycin, ganglefene, gainstigmine, gantacurium, gantofiban, imiquimod, imirestat, imitrodast, imolamine, imoxiterol, gapicomine, gapromidine, garenoxacin, gatifloxacin, gaves impacarzine, implitapide, impromidine, improsulfan, imu tinel, geclosporin, gedocarnil, gefarnate, gefitinib, gemaZo racetam, inamirone, inaperisone, incadronic acid, inda cine, gemcabene, gemcadiol, gemcitabine, gemeprost, gen caterol, indacrinone, indalpine, indanazoline, indanidine, fibtrozil, gemifloxacin, gemopatrilat, gentamicin, gepefrine, indanorex, indapamide, indatraline, indecainide, indelox gepirone, geroquinol, gestaclone, gestadienol, gestodene, azine, indenolol, indibulin, indigotindisulfonate, indinavir, gestonorone, gestrinone, geVotroline, gimatecan, gimeracil, indiplon, indisetron, indobufen, indocate, indocyanine giparmen, giracodaZole, giractide, girisopam, gitaloxin, green, indolapril, indolidan, indomethacin, indopanolol. gitoformate, glafenine, glaspimod, glatiramer acetate. gle indopine, indoprofen, indoramin, indorenate, indoxole, manserin, glenvastatin, gliamilide, glibotnuride, glib indriline, inecalcitol, ingliforib, inicarone, inocterone utimine, glicaramide, glicetanide, gliclazide, glicondamine, acetate, inogatran, inosine, inositol, improquoone, intopli glidaZamide, gliflumide, glimepiride, glipalamide, glipizide, cine, intrazole, intriptyline, inulin, iobenguane, iobenzamic gliquidone, glisamuride, glisentide, glisindamine, glisola acid, iobitridol, iobutoic acid, icanlidic acid, iocarmic acid, mide, glisoxepide, gloxazone, gloXimonam, glucametacin, iocetamic acid, iodamine, iodipamide, iodixanol, iodoan glucosamine, gluronolactone, glucuronamide, glunicate, tipyrine, iodocholesterol, iodohippurate, iodoquinol, iodot glyburide, glybuthiazole, glubuZole, gycopyrrolate, glycy hiouracil, idoxamic acid, iofetamine, ioflupane, iofratol, lamide, glyhexamide, glymidine, glyoctamide, glyparamide, ioglicic acid, ioglucol, ioglunide, ioglycamic acid, iogulaa glypinamide, glyprothiazole, gly Sobuzole, goralatide, gos mide, iohexol, iolidonic acid, iolixanic acid, iolopride, ioma erelin, gramicidin, granisetron, grepafloxacin, griseofulvin, Zenil, iomeglamic acid, iomeprol, iomethin, iometopane, guabenXan, guacetisal, guaifecainol, guaiactamine, guaiap iomorinic acid, iopamidol, iopanoic acid, iopentol, ate, guaietolin, guaifenesin, guaimeSal, guaisteine, guaith iophendylate, iophenoxic acid, iopromide, iopronic acid, yline, guanabenz, guanacline, guanadrel, guanaZodine, iopydol, iopydone, iosarcol, isofenamic acid, io.seric acid, guanclofine, guancydine, guanethidine, guanfacine, iosimenol, iosimide, iosulamide, iosumetic acid, iotasul, guanisoquin, guanoclor, guanoctine, guanoxabenz, guan ioteric acid, iothalamate, iothalamic acid, iotranic acid, oxan, guanoxyfen, gusperimus, halazepam, halazone, halci iotriside, iotrizoic acid, iotrolan, iotroXic acid, iotyrosine, nonide, halethazole, halobetasol, halocortolone, halofan iovesol, ioxabrolic acid, ioxaglic acid, ioxilan, ioxitalamic trine, halofenate, halofuginone, halometaSone, halonamine, acid, ioxotrizoic acid, ioZomic acid, ipamorelin, ipazilide, halopemide, halopenium, haloperidol, halopredone, halo ipenoxazone, ipexidine, ipidacrine, ipodate, iprgratine, ipra progesterone, haloprogin, haloxazolam, haloxon, halo midil, ipratropium, ipravacaine, iprazochrome, ipriflavone, qionol, hamycin, hedaquinium, heliomycin, hepronicate, iprindole, ipocinidine, iproclozide, iprocrodol, iprofenin, heptabarbital, heptaverine, heptolamide, hepzidine, heroin, iproheptine, iproniazide, ipronidazole, iproplatin, ipro hetacillin, hetaflur, heteronium, hexachlorophene, hexacy tiazem, iproxamine, iprozilamine, ipsalazide, ipsapirone, clonate, hexacyprone, hexadiline, hexafluorenium, hexam iquindamine, iralukast, irampanel, irbesartan, irindalone, ethonium, hexaminolevulinate, hexapradol, hexaprofen, irinotecan, irloxacin, irofulven, irolapride, iroXanadine, hexapropymate, hexasonium, hexazole, hexedine, hexestrol, irsogladine, irtemazole, isalidole, isalsteine, isamfaZone, hexetidine, hexobarbital, hexobendine, hexocyclium, hexo isamoltan, isamoxole, isatoribine, isaxonine, isbogrel, isbu prenaline, hexopyrronium, heylcaine, histamine, histapyrro fylline, ispamicin, isoamilinile, isobromindione, isobucaine, dine, histidine, homarylamine, homatropine, homidium, isobutamben, isocarboxazid, isoconazole, isocromil, isoet homochlorcyclizine, homofenazine, homopipramol, homo harine, isoflupredone, isoflurophate, isomazole, isomerol, salate, homprenorphine, hopantenic acid, hoquizil, hycan isometamidium, isomethadone, isometheptene, isomolpan, thone, hydracarbazine, hydralazine, hydragaphen, isoamylamine, isoniazid, isonixin, isoprazole, isopred hydrobentizide, hydrochlorothiazide, hydrocodone, hydro nidene, isoprofen, isopropamide, isopropicillin, isoproter cortisone, hydroflumethiazide, hydromadinone, hydromor enol, isoSrbide, isospaglumic acid, isosulfan blue, isosul phinol, hydromorphone, hydroquinone, hydroxyindasate, pride, isothipendyl, isotiquimide, isotretinoin, isoxaprolol. hydroxyindasol, hydroxocobalamin, hydroxyamphetamine, isoxepac, isoxicam, isoxSuprine, isradipine, israpafant, istr hydroxychloroquin, hydroxydione, hydroxypethidine, defylline, itameline, itanoXone, itasetron, itaZigrel, itopride, hydroxyphenamate, hydroxyprocaine, hydroxyprogester itraconazole, itriglumide, itrocainide, itrocinonide, iturelix, one, hydroxypyridine tartrate, hydroxystenozole, hydrox ivbradine, ivarimod, ivermectin, ivoqualine, ixabepilone, yStilbamidine, hydroxytetracaine, hydroxyzine, hymec iZonsteride, josamycin, kainic acid, kalafungin, kanamycin, romone, hyoscyamine, ibafloxacin, ibandronate, ibazocine, kebuZone, keracyanin, ketamine, ketanserin, ketazocine, ibopamine, ibrolipim, ibrotamide, ibudalast, ibufenac, ibu ketazolam, kethoxal, ketipramine, ketobemidone, ketocaine, profen, ibuproxam, ibutamoren, ibuterol, ibutilide, ibuver ketocainol, ketoconazole, ketoprofen, ketorfanol, ketorolac, ine, icaridin, icatibant, iclaprim, icazepam, icodulinium, ketotifen, ketotrexate, khellin, khelloSide, kitasamycin, labe icofungipen, ifometaSone, icopezil, icosapent, icospiramide, talol, labradimil, lachesine, lacidipine, lacosamide, lactal icotidine, icrocaptide, idarubicin, idaverine, idazoxan, ide fate, lactilol, lactulose, ladirubicin, ladostigil, laflunimus, benone, idenast, idoxifene, idoxuridine, idralfidine, idra lafutine, laidlomycin propionate, lamifiban, lamivudine, mantone, idraparinux, idrapril, idremcinal, idrociliamide, lamotrigine, lamitidine, lanatoside, landiolol, lanepitant, idronoxil, idropranolol, iferanserin, ifetroban, ifosfamide, lanicemine, laniquidar, lanoconazole, lanperisone, lanpros US 2007/01 16729 A1 May 24, 2007 29 ton, lanreotide, lanSoprazole, lapatinib, lapisteride, laprafyl mebutamate, mebutizide, mecamylamine, mecarbinate, line, lapyrium, lacquinimod, lasalocid, lasinavir, lasofox mecetronium, meciadanil, mecinarone, meclinertant, ifene, latanoprost, laudexium, laurcetium, laurocapram, meclizine, meclocycline, meclofenamaic acid, meclofenox lauroguadine, laurolinium, lauryl isoquinolinium, lavolti ate, meclonazepam, mecloqualone, meclorisone dibutyrate, dine, lazabemide, lecimibide, ledazerol, ledoxantrone, lefe mecloxamine, mecobalamin, medazepam, medazomide, tamine, leflunomide, lefradafiban, leiopyrrole, lemidosul, medetomidine, medibazine, medifoxamine, medorinone, lemidipine, leminoprazole, lemoxinol, lemuteporfin, lanali medorubicin, medrogestrone, medronic acid, medroxalol, domine, lenampicillin, lenapenem, leniquisin, leuperone, medroxyprogesterone acetate, medrylamine, medrysone, leptacline, lercanidipine, lergotrile, lerisetron, lesoptiron, mefeclorazine, mefenamic acid, mefenidil, mefenidramium, lestaurtinib, leteprinim, leteprinim, letimide, letosteine, mefenorex, mefeserpine, mefexamide, mefloquine, mefru letraZuril, letrozole, leucinocaine, leucocianidol, leucovorin, side, megalomycin, megestrol, megace, meglitinide, leurubicin, levalbuterol, levallorphan, levamfetamine, meglucycline, meglumine, meglutol, meladrizine, melagat levamisole, levcromakalim, levcycloserine, levdobutamine, ran, melarsomine, melarsonyl, melarsoprol, meldonium, levemoamil, levetiracetam, levisoprenaline, levlofexidine, melengestrol acetate, meletimide, melevodopa, melinamide, levmetamfetamine, levobetaxolol, levobunolol, levobupi melitracen, melizame, meloxicam, melperone, melphalan, acaine, levocabastine, levocarnitine, levodopa, levodro melduinast, meluadrine, mamantine, memotine, menabitan, propizine, levofacetoperane, levofenfluramine, levofloxacin, menadiol, menadione, menadoxime, menatetrenone, menb levofluraltadone, levoleucovorin, levomenol, levomepro utone, menfegol, menglytate, menitrazepam, menoctone, mazine, levomethadone, levomethadyl acetate, levometho menogaril, menobentine, mepazine, mepenZolate, meperi rphan, levometiomeprazine, levomoprolol, levomoramide, dine, mephenesin, mephenoxalone, mephentermine, mephe levonantradol, levonordefrin, levonorgestrel, levophenacyl nyloin, mephobarbital, mebaral, mepindolol, mepiperpheni morphan, levopropoxyphene, levopropylcilline, levopro dol, mepiprazole, mepiroXol, mepitioStane, mepivacaine, puylhexedrine, levoprotiline, levorin, levormeloxifene, mepixanox, mepramidil, meprednisone, meprobamate, levorphanol, levosalbutamol, levosemotiadil, levosimendan, meprochol, meproscillarin, meprotixol, meprylcaine, levosulpiride, levothyroxine, levotofisopam, levoxadrol, meptazinol, medulidox, meduinol, meduitamium, meduita lexipafant, lexithromycin, lexofenac, liarozole, libecillide, Zine, meradimqate, menthyl anthranilate, merafloxacin, libenzapril, licarbazepine, licofelone, licostinel, lidadronic meralein, meralluride, merbaphen, merbromin, mercaptom acid, lidamine, lidanserin, lidocaine, lidoferin, lidorestat, erin, mercaptopurine, mercuderamide, mercufenol, mercu lifariaine, lifibrate, lifibrol, lilopristone, limaprost, limazocic matilin, mergocriptine, meribendan, merimepodib, mero acid, linarotene, lincomycin, lindane, linetastine, lineZolid, penem, mersalyl, mertialide, mesabolone, mesalamine, linogliride, linopirdine, linotroban, lisinidomine, lintitript, meseclaZone, mesocarb, mesoridazine, mesipiperone, lintopride, liothyronine, lipoic acid, liraglutide, liranaftate, mespirenone, mestanolone, mesterolone, mestranol, mesu lirequinil, lirexapride, lirimilast, liroldine, lisadimate, lisi dipine, meSulergine, mesulfamide, meSulfen, meSuprine, nopril, lisofylline, lisuride, litomeglovir, litoxetine, litracen, metabromsalan, metbutethamine, metabutoxycaine, metac lividomycin, lixazinone, lixivaptan, lobapolatin, lobeline, etamol, metaclazepam, metacresol, metaglycodol, meta lobendazole, lobenzarit, lobucavir, lobuprofen, locicor hexamide, metalkonium, metalol, metamelfalan, metamfa tolone, lodaxaprine, lodaZecar, lodelaben, lodenosine, Zone, metamfenpramone, metampicillin, metanixin, Iodinixil, lodiperone, Iodoxamide, lofemizole, lofendazam, metapramine, metaproterenol, metaraminol, metaxalone, lofentanil, lofepramine, lofexidine, loflucarban, lombazole, metaZamide, metazide, matazocine, metbufen, meteneprost, lomefloxacin, lomeguarib, lomerizine, lometraline, lometr metergoline, metergotamine, metescufylline, metesculetol, exol, lomevactone, lomifylline, lomofungin, lomustine, metesind, metethoheptazine, metformin, methacholine, lonafarnib, lonapalene, lonaprofen, lonazolac, lonidamine, methacycline, methadone, methadyl acetate, methallenestril, loperamide, lopinavir, lopirazepam, lopobutan, loprazolam, methallibure, methalthiazide, methamphetamine, meth loracarbef, lorajmine, lorapride, lorazepam, lorbamate, andriol, methandrostenolone, methaniazide, methantheline, lorcainide, lorcinadol, loreclezole, lorglumide, methaphenilene, methapyrilene, methaqualone, metharbital, lormetazepam, lomoxicam, lopiprazole, lortalamine, methastyridone, methazolamide, methdilazine, meth lorZafone, losartan, losigamone, losindole, loSmiprofen, enamine, methenolone, metheptazine, methestrol, meth losoxantrone, losulazine, loteprednol, lotrafiban, lotrifen, etoin, methikcillin, methimazole, methiodal, methiomepra lotucaine, lovastatin, loviride, loxanast, loxapine, loxiglu Zine, methionine, methisaZone, methitural, methixene, mide, loxoprofen, loxoribine, lozilurea, lubazodone, lubelu methocarbamol, methocidin, methohexital, methopholone, Zole, lubiprostone, lucanthone, lucartamide, lucimycin, methoprene, methoserpidine, methotrexate, methotrimepra lufenuron, lufironil, lufuradom, luliconazole, lumiracoxib, Zine, methoxamine, methoXSalen, methoxyphedrine, meth lupitidine, luprostiol, lurasidone, lurosetron, lurototecan, oxyphenamine, methoxypromazine, methScopolamine, lusaperidone, luxabendazole, lydimycin, lymecycline, methSuximide, methyclothiazide, methyl aminolevulinate, lynestrenol, lypressin, mabuprofen, mabuterol, madurami methyl palmoxirate, methyl salicylate, methylatropine, cin, mafenide, mafoprazine, mafosfamide, malathion, methylbenactyzium, methylbenzethonium, methylcromone, maleylsulfathiazole, malotilate, mangafodipir, manidipine, methyldesorphine, methyldihydromorphine, methyldopa, manifaxine, mannomustine, manoZodil, mantabegron, mapi methylene blie, methylephedrine, methylergometrine, meth nastine, maprotiline, maraviroc, marbofloxacin, maribavir, ylergonovine, methyllparaben, methylphenidate, methyl maridomycin, marimastat, mariptiline, maropitant, maroX prednisolone, methyltestosterone, methylthiouracil, meth epin, masoprocol, maxacalcitol, maytansine, mazapertine, ynodiol, methyprylon, methysergide, metiamide, metiapine, maZaticol, mazindol, maZipredone, mazokalim, mebana metiazinic acid, metibride, meticrane, metildigoxin, metin Zine, mebendazole, menbenoside, mebeverine, mebeZo dizate, metioprim, metioxate, metipirox, metiprenaline, nium, mebhydrolin, mebiquine, mebolazine, mebrofenin, metitepine, metizoline, metkephamid, metochalcone, meto US 2007/01 16729 A1 May 24, 2007 30 cinium, metoclopramide, metocurine, metofenazate, nebivolol, neboglamine, nebracetam, nebramycin, necopi metogest, metolaZone, metomidate, metopimazine, meto dem, nedaplatin, nedocromil, nefazodone, nefiracetam, pon, metoprine, metoprolol, metoquizine, metoserpate, neflumozide, nefopam, nelarabine, neldaZosin, neleZaprine, metostilenol, metoxepin, metrafazoline, metralindole, nelfinavir, meltenexine, nelZarabine, nemadectin, nemaZo metrazifone, metrenperone, metribolone, metrifonate, met line, nemifitide, nemonapride, memorubicin, neocinchophen, rifudil, metrizamide, metrizoate, metronidiazole, meture neomycin, neostigmine, nepadutant, nepafenac, nepapra depa, metyrapone, metyrosine, mevastatin, mexafylline, Zole, nepicastat, nepinalone, nequinate, neramexane, mexazolam, mexenone, mexiletine, mexiprosil, mexopro neraminol, nerbacadol, neridronic acid, nerisopam, nesapi fen, meXrenoate, meZacopride, meZepine, meZilamine, dil, nesiritide, nesosteine, nestifylline, neticonazole, netilmi meZlocillin, miaanserin, mibefradil, mibolerone, miboplatin, cin, netivudine, netobimin, netoglitaZone, netupitant, neu micafungin, miconazole, micronomicin, midaflur, midafotel, tramycin, neviparine, nexeridine, nexopamil, niacin, midaglizole, midamaline, midaxifylline, midazogrel, mida niacinamide, nialamide, niaprazine, nibroxane, nicafenine, Zolam, midecamycin, midestein, midodrine, midostaurin, nicainoprol, nicametane, nicanartine, nicaraven, nicarbazin, mifentidine, mifepristone, mifobate, miglitol, miglustat, nicardipine, nicergoline, niceritol, niceverine, niclofolan, mikamycin, milacainide, millacemide, milameline, niclosamide, nicoboxil, nicoclonate, nicocodine, nicocor milataxel, milenperone, milfasartan, millipertine, miloxacin, tonide, nicocidodine, nicoduozide, nicofibrate, nicofura milrinone, miltefosine, milverine, mimbane, minalrestat, nose, nifurate, nicogrelate, nicomol, nicomorphine, nicop minamestane, minaprine, minaXolone, mindodilol, mindop holine, nicoracetam, nicorandil, nicothiazone, nicotredole, erone, minepentate, minocromil, minocycline, minodronic nicoXamat, nictiazem, nictindole, nidroxy Zone, nifedipine, acid, minopafant, minoxidil, mioflaazine, mipitroban, nifekalant, nifemalol, nifenaZone, niflumic acid, nifungin, mipragoside, miproxifene, mirfentanil, mirincamycin, mir nifuradene, nifuraldeZone, nifuralide, nifuratel, nifuratrone, ipirium, miriplatin, mirisetron, miristalkonium, miroprofen, nifurdazil, nifurethazone, nifurfoline, nifurimide, nifuri mirosamicin, mirostipen, mirtazapine, misonidazole, miso Zone, nifurmazole, nifurmerone, nifuroquine, nifuroxazide, prostol, mitemcinal, mitiglinide, mitindomine, mitobronitol, nifuroxime, nifurpipone, nifurpirinol, nifurprazine, mitocarcin, mitoclomine, mitocromin, mitoflaxone, mitogil nifurquinazol, nifursemizone, nifursol, nifurthiazole, nifur lin, mitoguaZone, mitolactol, mitomalcin, mitomycin, timox, nifurtoinol, nifurvidine, nifurzide, nigludipine, nihy mitonafide, mitopodozide, mitoquidone, mitosper, mitolane, draZone, nikethamide, nileprost, nilprazole, niludipine, mitotenamine, mitoxantrone, mitoZolomide, mitradipide, nilutamide, nilvadipine, nimaZone, nimeSulide, mivacurium, mivobulin, mivotilate, mixidine, mizolastine, nimetazepam, nimidane, nimodipine, nimorazole, nimus mizoribine, mobecarb, mobenzoxamine, mocimycin, tane, neometacin, niperotidine, nipradillol, niprofaZone, mociprazine, moclonemide, moctamide, modafinil, moda nitavoline, nirdazole, nisbuterol, nisobamate, nisoldipine, line, modecainide, modipafant, moexipril, moexiprilat, nisoxetine, nisterime, nitarSone, nitaZoxanide, nitecapone, mofarotene, mofebtaZone, mofegiline, mofeZolac, moflover nithiamide, nitisinone, nitracrine, nitrafudan, nitralamine, ine, mofoxine, mofuisteine, molfarnate, molinaZone, molin nitramisole, nitraduaZone, nitrazepam, nitrefazole, nitren done, molracetam, molsidomine, mometasone, monalaZone, dipine, nitrocefin, nitroclofene, nitrocycline, nitrodan, nitro monatepil, monesin, monobenzone, monoctanoin, furantoin, nitrofuraZone, nitromersol, nitromide, monometacrine, monophosphothiamine, monoxerutin, mon nitromifene, nitroscanate, nitrovin, nitroXinil, nitroxoline, telukast, monterelin, moperone, mopidamol, mopidralazine, nivaZol. nivimedone, nizatidine, nizofenone, noberastine, moprolol, moquizone, morantel, moraZone, morclofone, nocloprost, nocodazole, nofecainide, nogalamycin, nolatr morforex, moricizine, morinamide, momiflumate, moro exed, nolinium, nolomirole, nolpitantium, nomegestrol, cromen, moroxydine, morpheridine, morphine, morSuxim nomelidine, nomifensine, nonabine, nonaperone, nonapy ide, mosapramine, mosapride, motapizone, motexafin, rimine, nonathymulin, nonivamide, noracymethadol, norbo motrazepam, motrtinide, moveltipril, moxadolen, moxalac lethone, norbudroine, norcholestenol, norclostebol, norco tam, moxaprindine, moxastine, moXaverine, moxazocine, deine, nordazepam, nordefrin, nordinone, norelgestromin, moxestrol, moxicoumone, moxidectin, moxifloxacin, moxi norepinepherine, norethandrolone, noethindrone, nor lubant, moxipraquine, moxirapine, moxisylate, moXnida ethynodrel, noreximide, norfenefrine, norfloxacin, norgest Zole, moxonidine, moZavaptan, moZenavir, mubritnib, erone, norgestimate, norgestomet, norgestrel, norg mupirocin, murabutide, muraglitazar, mureletecan, estrieneone, norletimol, norlevorphenol, normethadone, murocainide, muZolimine, mycophenolic acid, my fadol, normorphine, norpipanone, nortetrazepam, nortopixantrone, myrophine, myrtecaine, nabaZenil, nabilone, nabitan, nab nortriptyline, norvinisterone, nosantine, noscapine, nosihep octate, nabumetone, nacartocin, nadide, nadiofloxacin, nad tide, novobiocin, noxiptiline, noxytiolin, nuclomedone, olol, nadoxolol, nafagrel, nafamo.stat, nafarelin, nafazatrom, nuclotixene, nufenoXole, nupafant, nuvenZepine, nylestriol, nafcaproic acid, nafcillin, nafenodone, nafenopin, nafetolol. nylidrin, nystatin, obidoxime, ocaperidone, ocfentanil, ocilt nafimidone, nafiverine, naflocort, nafomine, nafoxadol, ide, ocinaplon, octacaine, octafonium, octamoxin, octapinol, nafoxidine, nafronyl, naftalofos, naftaZone, naftifine, nafto octatine, octaverine, octaZamide, octenidine, Octicizer, pidil, naftoxate, naftypamide, naglivan, nalbuphine, nal octimibate, octinoxate, octisalate, octocrylene, octodrine, furafine, nalidixic acid, nalmefene, nalmexone, nalorphine, octopamine, octotiamine, octreotide, octriptyline, octriazole, naloxone, naltrexone, naminidil, naminterol, namirotene, odalprofen, odapipam, odiparcil, ofloxacin, oftomine, oftas namoXyrate, nanafrocin, nandrolone, nanterinone, nantra ceine, oglu fanide, olaflur, olamufloxacin, olanexidine, olan dol, napactadine, napamezole, naphazaoline, naphthonone, Zapine, olaquindox, olcegepant, oleandomycin, oletimol, napirimus, napitane, naproxime, naproxen, naproxol, nap olmesartan, olopatadine, olpadronic acid, olpimedone, sagatran, naranol, narasin, naratriptan, nardetoterol, naro olprinone, olradipine, olsalazine, oltipraz, olvanil, omaci parcil, natamycin, nateglinide, navuridine, naxagolide, nax clovir, omapartrilat, omeprazole, omidoline, omigapil. aprosteine, naxifylline, nealbarbital, nebantan, nebidrazine, omiloxetine, omoconazole, omonasteine, onapristone, US 2007/01 16729 A1 May 24, 2007 31 ondansetron, ontazolast, ontianil, opanixil, opaviraline, toxyverine, pentrinitrol, pentylenetetraZol, peplomycin, pep opiniazide, opipramol, opratonium, oraZamide, oraZipone, statin, peraclopone, peradoxime, perafensine, peralopride, orbofiban, orbutopril, orconazole, orientiparcin, oritavancin, peramivir, peraquisin, perastine, peratizole, perazine, perbu orlistat, ormaplatin, ormeloxifene, ormetoprin, ornidazole, fylline, perfomedil, perfosfamide, pegolide, perhexiline, ornipreessin, ornithine, ornoprostil, orotic acid, orotirelin, periciazine, perifosine, perimetazine, perindopril, perindop orpanoxin, orphenadrine, ortataxel, orteteamine, osanetant, rilat, perisoxal, perlapine, permethrin, peroSpirone, per OSaterone, oseltamivir, OSemoZotan, osmadizone, phenazine, persilic acid, perZinfotel, petrichloral, peXantel, ospennifene, ostreogrycin, oSutidine, otamixaban, otenZe phanquone, phenacaine, phenacemide, phenacetin, phenac pad, oteracil, otilonium, otimerate, ouabain, Oxabolon, tropinium, phenadoxone, phenaglycodol, phenamaZoline, oXabrexine, oxaceprol, oxacillin, oxadimedine, oxafloZane, phenampromide, phenaphthazine, phenarsone, phenazocine, oxaflumazine, oxagrelate, oxalinast, oxaliplatin, OXamarin, phenaZopyridine, phenbutaZone, phencarbamide, phencyc Oxametacin, oxamisole, oxaminiquinem oxanamide, oxan lidine, phendimetrazine, phenelZine, pheneridine, phenethi drolone, oxantel, oxapadol, oxapium, Oxaprazine, oxapro cillin, pheneturide, phenylglutarimide, phenicarbazide, tiline, oxaprozin, oXcarbazole, Oxatomide, oxazafone, phenindamine, phenindione, pheniprazine, pheniramine, oxazepam, oxazidone, oxazolam, oxazorone, oXcarba phenisonone, phenmetrazine, phenobarbital, phenobutiodil, Zepine, oxdralazine, oxeclosporin, oxedrine, Oxeglitazar, phenomorphan, phenothiazine, phenothrin, phenoxyben oxeladin, Oxendolone, oxepinac, oxetacillin, oxethazine, Zamine, phenoxypropazine, phenprobamate, phenprocou oxetorone, Oxfendazole, Oxfenicine, oxibendazole, Oxibe mon, phenpromethamine, phensuXimide, phentermine, taine, oxiconizole, oxidapamine, oxidronic acid, Oxfentorex, phentolamine, phenyl aminosalicylic acid, phenylalanine, oxifungin, oxigluttione, oxillofrine, OXilorphan, oXimonam, phenylbutaZone, phenylephrine, phenylpropanolamine, phe oXindanac, oxiniacic acid, Oxperomide, oxiracetam, oxira nylthiolone, phenyltoloxamine, phenyracillin, phenyrami mide, oxisopred. Oxisuran, oxitefonium, oxitriptan, oxitrip dol, phenyloin, pnetharbital, pholcodine, pholedrine, tyline, oxtriponium, OXmetidine, oxodipine, oxogestone, phoxim, phthalofyne, phthylsulfacetamide, phthalylsul oXolamine, oxolinic acid, oXomermazine, oXonazine, famethiazole, phthalylsulfathiazole, physostigmine. Phytic Oxophenarsine, Oxoprostol, oxpheneridine, Oxprenoate, acid, phytonadione, pibaxizine, pibecarb, piberaline, pibos oXprenolol, oxtriphylline, oxbenZone, oxybutynin, oxychlo erod, pibroZelesin, pibutidien, picafibrate, picartamide, rosene, oxycinchophen, oxyclipine, oxyclozanide, oxyc picenadol, picilorex, piclaimilast, piclonidine, piclopastine, odone, oxydipentonium, oxyfedrine, oxymesterone, picloxydine, picobenzide, picodralazine, picolamine, oxymetazoline, oxymethalone, oxymorphone, oxypendyl. piconol, picoperine, picoplatin, picoprazole, picotamide, oxypertine, oxyphenbutaZone, oxyphencyclimine, picotrin, picumast, picumeterol, pidobenzone, pidolaceta oxyphenisatin, oxyphenonium, oxypurinol, oxypurronium, mol, pidolicaica, pidotimod, pifarnine, pifinate, pifexole, oxyquinoline, oxyridazine, oxysonium, oxytetracycline, piflutiXol, piketoprofen, pildralazine, pilocarpine, pilsicain oxytocin, oZagrel, oZagamicin, oZolindone, paclitaxel, ide, pimagedine, pimeclone, pimecrolimus, pimefylline, pacrindolol, pactimibe, padimate A, padimate Q, pafenolol. pimelautide, pimetacin, pimethixene, pimetine, imetremide, pagoclone, paldimycin, palinavir, paliperidone, palmidrol, pimilprost, piminodine, pimobendan, pimonidazole, palmoxirate, palonidipine, palonosertron, palosuran, pam pimozide, pinacidil, pinadoline, pinafide, pinaverium, abron, pamaqueside, pamaquin, pamicogrel, pamidronic pinazepam, pincainide, pindolol, pinokalant, pinolcaine, acid, panadiplon, panamesine, pancopride, pancuronium, pinoxepine, pioglitaZone, pipacycline, pipamazine, pipam panipenem, panomifene, pantenicate, pantethine, panthenol, perone, pipaZethate, pipebuZone, pipecuronium, pipemidi pantoprazole, panuramine, papverine, papveroline, cacid, pipendoxifene, pipenZolate, pipequaline, piperac parachlorphenol, paraflutizide, paramethadione, parametha etazine, piperacillin, piperamide, piperidolate, piperilate, Sone acetate, paranitrosulfathiazole, paranyline, parapen piperocaine, piperonyl butoxide, piperoxan, piperphenidol. Zolate, parapropamol, pararosaniline, paraxaZone, parbenda piperylone, pipobroman, pipoctanone, pipofezine, piposul Zole, parcetasal, parconazole, parecoxib, pareptide, fan, pipotiazine, pipoxizine, pipoxolan, pipradimadol, parethoxycaine, pargeverine, pargolol, pargyline, paricalci pipradrol, pipramadol, pipratecol, piprinhydrinate, tol, paridocaine, parodilol, paromomycin, paroxetine, par pipocurarium, piprofurol, piprozolin, piquindone, piquizil, oxypropione, parsalmide, particin, parvaquone, pasiniazid, piracetam, pirandamine, pirarubicin, piraxelate, pirzmonam, pasireotide, patamostat, patupilone, paulomycin, paxamate, piraZolac, pirbenicillin, pirbuterol, pirdonium, pirenoXine, paZelliptine, paZinaclone, paZOxide, paZufloxacin, pecilocin, piremperone, pirezepine, pirepolol, piretanide, pirfenidone, pecocycline, pefloxocin, pelanserin, peldesine, peliomycin, pirbendil, piridicillin, piridocaine, piridoxilate, piridronic pelitinib. pelitrexol, pelretin, pelrinone, pelubiprofen, acid, pirifibrate, pirimiphos-ethyl, pirindazole, pirinixic pemedolac, pemerid, pemetrexed, pemirolast, pemoline, acid, pirinixil, piriprost, piriqualone, pirisudanol, piritra penamecillin, penbutolol, penciclovir, pendecamine, pen mide, piritrexin, pirlimycin, pirlindole, pirmagrel, pirmenol, detide, penfluridol, penflutizide, pengitoxin, penicillamine, pirinabine, piroctone, pirodavir, priodomast, pirogliride, penicillin G, penicillin V, penimepicycline, penimocycline, piroheptine, pirolate, pirolaZamide, piromidic acid, piroX penirolol, penmesterol, penoctonium, penprostene, pent antrone, piroXicam, piroxicillin, piroXimone, pirozadil, pir abamate, pentacynium, pentfluranol, pentagastrin, pentag profen, pirquinozol, pirralkonium, pirsidomine, pirtenidine, estrone, pentalamide, pentamethonium, pentamidine, penta pitenodil, pitofenone, pituxate, pivagabine, pivampicillin, morphone, pentamoxane, pentamustine, pentapiperide, pivenfrine, pivopril, pivoxazepam, pixantrone, pizotyline, pentapiperium, pentaquine, pentazocine, pentetic acid, pen plafbride, plaunotol, plauracin, pleconaril, pleuromulin, treotide, penthienate, penthrichloral, pentiapine, pentifyl plevitrexed, plicamuycin, plomestane, pobilukast, podilfen, line, pentigetide, pentisomicin, pentisomeide, pentizidone, podofilox, poldine, polymixin, polythiazide, pomisartan, pentobarbital, pentolinium, pentolonium, pentomone, pen ponalrestat, ponaZuril, ponfibrate, porfiromycin, posacona topril, pentorex, pentosalen, pentostatin, pentoxifylline, pen Zole, posatirelin, posiZolid, poskine, practolol, pradolfoxa US 2007/01 16729 A1 May 24, 2007 32 cin, prajmalium, pralatrexate, pralidoxime, prailmorelin, ramorelix, ramosetron, ranelic acid, ranimustine, ranimycin, pralnacasan, pramipexole, pramiracetam, pramoxine, ranirestat, ranitidine, ranolaine, rapacuronium, rasagiline, prampine, pranazepide, pranidipine, prankulast, pranolium, rasburicase, rathyronine, ravuconazole, raZaxaban, razin pranoprofen, pranosal, prasterone, prasugrel, pratosartan, odil, raZobazam, raZOxane, rebimastat, reboxetine, pravadoline, pravastatin, praxadine, praZarelix, prazepam, recainam, reclazepam, regadenoson, reglitazar, relcovaptan, prazepine, praziquantel, praZitone, prazocillin, praZosin, relomycin, remacemide, remifentanil, remikiren, remipros preclamol, prednazate, prednazoline, prednicarbate, predni tol, remoxipride, renanolone, rentiapril, renzapride, repa mustine, prednisolamate, prednisolone, prednisone, predni glinide, reparixin, repinotan, repirinast, repromicin, reprot val, prednylidene, pregabalin, pregnadiol, pregnenolone, erol, rescimetol, rescinnamine, resequinil, reserpine, premafloxacin, premazepam, prenalterol, prenisteine, pren residuimod, resocortol butyrate, resorantel, resorcinol, reta overine, prenoxdiazine, prenylamine, pretamazium, pretia pamulin, retelliptine, retigabine, retinol, revaprazan, revat doil, prezatide, pribecaine, pridefine, prideperone, pridinol, ropate, revenast, reviparin, revizinone, revospirone, ribavi prifelone, prifinium, prifuroline, pilocalne, primaperone, rin, riboflavin, riboprine, ribostamuycin, ricasetron, primaquine, primidolol, primidone, primycin, prinomastat, ridazolol, ridogrel, rifabutin, rifalazil, rifametane, rifamexil, prinomide, prinoXodan, pristinol, pristinamycin, prizidilol. rifamide, rifampin, rifapentine, rifaximin, rilapine, ril proadifen, probarbital, probenecid, probicromil, probucol, makalim, rilmazafone, rillmenidine, rilopirox, riloZarone, procainamide, procaine, procarbazine, procaterol, prochlor rillpovorine, riluzole, rimantadine, rimazolium, rimcazole, perazine, procinolol, procinonide, proclonol, procromil, pro rimexolone, rimiterol, rimonabant, rimoprogin, riodipine, cyclidine, procymate, prodeconium, prodilidine, prodipine, rioprostil, ripazepam, ripisartan, risarestat, risedronicacid, prodolic acid, profadol, profexalone, proflavine, risocaine, risotilide, rispenzepine, risperidone, ristianol, ris proflazepam, progabide, progesterone, proglumetacin, pro tocetin, ritanserin, ritometan, ritipenem, ritobegron, rito glumide, proheptazine, proligestone, praline, prolintane, drine, ritolukast, ritonavir, ritropirronium, ritrosulfan, rivar prolonium, promazine, promegestone, promestriene, Oxaban, rivastigmine, rivoglitaZone, rizatriptan, robalZotan, promethazine, promolate, promoxolane, prontalol, propac robenidine, rocastine, rocepafant, rociclovir, rocuronium, etamol, propafenone, propagermanium, propamidine, pro rodocaine, rodorubicin, rofecoxib, rofelodine, rofileponide, panidid, propanocaine, propantheline, proparacaine, pro roflumilast, rogletimide, rokitamycin, rollafagrel, roletamide, patyl nitrate, propazolamide, propenidazole, rolgamidine, rolicyclidine, rolicyprine, rolipram, rollitetra proprintofylline, propenZolate, properidine, propetamide, cycline, rolodine, rolziracetam, romazarit, romergoline, propetamfos, propetandrol, propicillin, propikacin, propin romifenone, romifidine, romurtide, ronactolol, ronidazole, etidine, propiomazine, propiocaine, propiram, propisergide, ronifibrate, ronipamil, runnel, ropinirole, ropitoin, ropiv propiverine, propizepine, propofol, propoxate, propoXur, acaine, ropizine, roquinimex, rosaprostol, rosaramicin, rose propoxycaine, propoxyphene, propranolol, propyl docetri bengal, rosiglitaZone, roSoxacin, rostafuroxin, rostaporfin, Zoate, propyl gallate, propylhexedrine, propyliodone, pro rosterolone, rosuvastatin, rotamicillin, rotigotine, rotoxam pylthiouracil, propyperone, propyphenaZone, propyro ine, rotaxate, roXadimate, roXarsone, roXatidine acetate, mazine, produaZone, produinolate, prorenoate, proroXan, roxibolone, roxifiban, roXindole, roXithromycin, roXolo prScillardin, prospidium, prostalene, proSulpride, prosul nium, roXoperone, rubitecan, ruboxistaurin, rufinamide, tiamine, proterguride, protheobromine, prothipendyl, pro rufloxacin, rupatadine, rupintrivir, rutamycin, ruvaZone, thixene, protiofate, protionamide, protirelin, protizinic acid, ruzadolane, Sabarubicin, Sabcomeline, sabeluzole, Sabi protokylol, protoporphyrin, protriptyline, proXZole, proxi poride, Saccharin, Safingol, Safirinol, Sagandipine, salaceta barbal, proxibutene, proXicromil, proxifeZone, proXorphan, mide, Salafibrate, salantel, Salazodine, Salazosulfadimidine, proxymetacaine, proxyphylline, proZapine, prucalopride, salaZoSulfamide, Salazosulfathiazole, Salcaprozoic acid, sal prulifloxacin, pruvanserin, pseudoephedrine, pumafentrine, colex, Salethamide, Salflucerine, Salicyl alcohol, salicyla pumaprazole, pumitepa, pumosetrag, puromycin, pyrabrom, mide, Salicylic acid, salinazid, salinomycin, salmefamol. pyrantel, pyrathiazine, pyrazinamide, pyrazofurin, pyricar salmeterol, Salmisteine, Salnacedin, Salprotoside, Salsalate, bate, pyridarone, pyridinol, pyridofylline, pyridostigmine, sameridine, Samixogrel, Sampatrilat, Sampirtine, sancycline, pyridoxal, pyridoxamine, pyridoxine, pyrilamine, Sanfetrinem, sanguinarium, Saperconazole, Saprisartan, pyrimethamine, pyrimate, pyrinoline, pyrithione, pyrithyl sapropterin, saquinavir, Sarafloxacin, Sarakalim, Saralasin, dione, pyritidium, pyritinol, pyrophenindane, pyrovalerone, sarcolysin, Sardomozide, Saredutant, Saripedem, Sarizotan, pyroxamine, pyrrobutamine, pyrrocaine, pyrrolifene, pyrro SarmaZenil. Samoxicillin, Sarpicillin, Sarpogrelate, liphene, pyrrolnitrin, pyrroxane, pyrvinium, pytamine, saterinone, satigrel, satranidazole, satraplatin, saviprazole, quadazocine, quadrosilan, quatacaine, quaZepam, quazi savoxepin, scopafungin, scopinast, Scopolamine, Secalcif none, quaZodine, quaZolast, quetiapine, quifenadine, qui erol, seclaZone, secnidazole, secobarbital, securinine, sede flapon, quillifoline, quilostigmine, quinacainol, quinacillin, camycin, Sedoxantrone, Seganserin, Segesterone, Seglitide, quinacrine, quinagolide, quinaldine blue, quinapril, quinap Selamectin, Selgiline, selfotel, Soldenoson, selprazine, rilat, quinazosin, quibolone, quincarbate, quindecamine, sampimod, sematilide, Semaxanib, semduramicin, semor quindonium, quindoxin, quinelorane, quinestradol, phone, Semotiadil, Semustine, SenaZodan, Seocalcitol, sepa quinestrol, quinethaZone, quinetolate, quinezamide, quinfa Zonium, Seperidol, sepimostat, Seprilose, seproxetine, mide, quingestanol acetate, quingestrone, quinidine, qui sequifenadine, seratrodast, Serazapine, serfibrate, Sergolex nine, quinotolast, quinpirole, quinterenol, quitiofos, quinu ole, Sermetacin, sertindole, Sertraline, setastine, Setzindol, clium, quinupramine, quinupristin, quipazine, quisultazine, setipafant, setiptiline, Setoperone, Sevitropium, Sevopra rabeprazole, raclopride, ractopamine, radafaxine, rafox mide, Sezalamide, Sagoside, sibenadet. Sibopirdine, anide, ragaglitazar, ralitoline, raloxifene, raltitrexed, raluri Sibrafiban, Sibutramine, siccanin, Sifrprazine, SiguaZodan, dine, ramatroban, ramciclane, ramelteon, ramifenaZone, silandrone, sildenafil. Silibinin, Silcristin, sildianin, silo ramipril, ramiprilat, ramixotidine, ramnodigin, ramnoplanin, dosin, silodrate, silperisone, siltenZepine, simendan, sim US 2007/01 16729 A1 May 24, 2007

etride, Simfibrate, simtraZene, simvastatin, sincalide, sine rostene, tarazepide, tariquindar, tasosartan, tasuldine, tauro fungin, Sinitrodil, sintropium, sipatrigine, Siramesine, lidine, tauromustine, tauroselcholic acid, taurosteine, taza siratiazem, sirolimus, Sisomicin, Sitafloxacin, Sitalidone, dolene, tazanolast, tazarotene, taZaSubrate, taZeprofen, Sitamaquine, sitaxentan, sitofibrate, sitoglusoide, sivelestat, taZifylline, taZiprinone, taZobactam, tazofelone, tazolol. Soblidotin, Sobuzoxane, Solabegron, Solifenasin, Solimastat, tazometime, tebanicline, tebatizole, tebipenem, tebufelone, Solpecainol, Solypertine, Somatadine, Soneclosan, Sonepipra tebuquine, tecadenoson, tecalcet, tecastemizole, teclthiaz Zole, sopitazine, Sopromidine, Soquinolol, Sorafenib, Sora ide, teclozan, tedisamil, tefazoline, tefenperate, teflufazine, prazan, Sorbinicate, Sorbinil, Sorivudine, Sornidipine, Sotalol, teflutiXol, tegafur, tegaserod, teglicar, teicopamin, telavancin, Soterenol, Spaglumic acid, sparfloxacin, sparfosate, sparso telbivudine, telenzepine, tellinavir, tellithromycin, telm mycin, Sparteine, spectinomycin, spiclamine, spiperone, Spi esteine, telmisartan, teloxantrone, teludipine, temafloxacin, radoline, spiramide, spiramycin, spirapril, spiraprilat, temarotene, tematropium, temazepam, temefos, temelastine, spirendolol, spirgetine, spirilene, spiriprostil, spirofylline, temiverine, temocapril, temocaprilat, temocillin, temodox, spirogermanium, Spiroglumide, spiromustine, spironolac temoporfin, temozolomide, temisirolimus, temurtide, ten tone, spiroplatin, spirorenone, Spirotriazine, SpiroXasone, amfetamine, tenatoprazole, tendamistat, tenidap, tenilapine, spiroXatrine, spiroXepin, Spizofurone, Sprodiamine, teniloxazine, tenilsetam, teniposide, tenivastatin, tenocycli squalamine, squalane, stacofylline, stillimycin, Stannsoprfin, dine, tenofovir, tenofovir disoproxil, tenonitrozole, tenosal, stanolone, stanoaolol, stavudine, Stearylsulfamide, Steflimy tenosiprol, tenoxicam, tenylidone, teoprantil, teoprolol. cin, Stenbolone, strpronin, Stercuronium, Stevaladil, Stibam tepirindole, tepoxalin, teprenone, teprotide, teraZosin, terbe ine, Stibophen, Stilbamidine, stilbazium, Stilonium, Strima quinil, terbinafine, terbogrel, terbucromil, terbufirol, terbu Zole, Stiripentol, stirocainide, Stirofos, Streptomycin, ficin, terbuprol, terbutaline, terciprazine, terconazole, terde streptonicozid, Streptonigrin, Streptozocin, styramine, Sub camycin, teerestigmine, terfeadine, terflavoxate, terfluranol, athiazone, Subendazole. Succinylcholine. Succinylsulfathia terguride, teriflunomide, terikalant, terizidone, terlakiren, Zole. Succisulfone, Suclofenide. Sucralfate. Sucralose, terlipressin, ternidazole, terodiline, terofenamate, teroX Sucrose octaacetate. SucroSufate, Sudexanox, Sudoxicam, alene, teroxirone, tertatolol, tesaglitazar, tesicam, tesimide, Sufenatil, Sufotidine, Sufugolix, Sugammadex, Sulamserod, tesimilifene, tesofensine, testolactone, testosterone, tetom Sulazepam, SulaZuril, Sulbactam, Sulbenicillin, Sulbenox, ilst, tetrabarbital, tetrabenazine, tetracaine, tetracycline, tet Sulbentine, Sulbutiamine, Sulclamine, Sulconazole, Sulfa rahydrozoline, tetramethrin, tetramisole, tetraxetan, tet benz, Sulfabenzamide, Sulfabromomethazine, Sulfacarbam razepam, tetraZolast, tetriprofen, tetrofosmin, tetronasin, ide, sulfacecole, sulfacetamide, sulfachlorpyridazine, sul tetroquinone, tetroxoprin, tetrydamine, teverelix, texacro fachrysoidine, Sulfaclomide, Sulfaclorazole, Sulfaclozine, mil, tezacitabine, tezosentan, thalidomide, thebacon, Sulfacytine, Sulfadiazine, Sulfadimethoxine, Sulfadoxine, thenalidine, thenium, thenyldiamine, theobromine, theo Sulfaethidole, Sulfaguanidine, Sulfaguanole, Sulfalene, Sul drenaline, theofibrate, theophylline, thiabendazole, thiac faloxic acid, SulfamaZone, Sulfamerazine, Sulfameter, Sul etarsamide, thialbarbital, thiamazole, thiamine, thiamiprine, famethazine, Sulfamethizole, Sulfamethoxazole, Sul thiamphenicol, thamylal, thiazesim, thiazinamium, thiazol famethoxypyridazine, Sulfametmidline, sulfametrole, sulfone, thiethyperazine, thihexinol ethylbromide, thimer Sulfamonomethoxine, Sulfamoxole, Sulfanilamide, Sulfa fonate, thimerosal, thiocolchicoside, thioctic acid, thio nilate, Sulfaanitran, Sulfaperin, Sulfaphenazole, Sulfaproxy furadene, thioguanine, thiohexamide, thioinosine, line, Sulfapyridine, Sulfaquinoxaline, Sulfarsphenamine, Sul thiopental, thiophanate, thiopropazate, thioproperazine, fasalazine, Sulfasomizole, SulfaSuccinamide, Sulfasymazine, thioridazine, thiosalan, thiostrpton, thiotepa, thiotetrabar Sulfathiazole, Sulfathiourea, Sulfatolamide, Sulfatroxazole, bital, thiothixene, thiphenamil, thiphencillin, thiram, Sulfatrozole, Sulfazamet, Sulfinaolol, Sulfinpyrazone, Sul thonzonium, thonzylamine, thoZalinone, threonine, thy firam, Sulfisomidine, Sulfisoxazole, Sulfobromophthalein, mocartin, thymoctonan, thymol, thymopentin, thymotrinan, Sulfonterol, Sulforidazine, Sulfosalicylic acid, Sulfoxone, Sul thyromedan, thyropropic acid, thyroxin, tiacrilast, tiadenol, crinat, Sulindac, Sulisatin, Sulisobenzone, Sulmarin, Sulma tiafibrate, tiagabine, tiamenidine, tiametomnium, tiamulin, Zole, Sulmepride, Sulnidazole, Sulocarbilate, Suloctidil, Sulo tianafac, tianeptine, tiapamil, tiapirinol, tiapride, tiaprofenic dexide, Sulofenur, Sulopenem, Sulosemide, Sulotroban, acid, tiaprost, tiaramide, tiazofurin, tiaZuril, tiabalosin, tibe Suloxifen, Sulpiride, Sulprosal, Sulprostone, Sultamicillin, glisene, tibenelast, tibenzate, tibeZonium, tibolone, tibric Sultiame, Sultopride, Sultosilic acid, Sultroponium, Sulukast, acid, tibrofan, ticabesine, ticalopride, ticarbodine, ticarcillin, Sulverapride, Sumacetamol, Sumanirole, Sumarotene, ticlatone, ticlopidine, ticolubant, ticrynafen, tidembersat, Sumatriptan, Sumetizide, Sunagrel, Suncillin, Sunepitron, tidiacic acid, tiemonium, tienocarbine, tienopramine, tienox Supidimide, Supalast, Suproclone, Suprofen, Suramin, Suric olol, tifemoxone, tifenazoxide, tiflamizole, tiflorex, tiflua ainide, Suriclone, SuritoZole, Suronacrine, Susalimod, Sux dom, tiflucarbine, tiformin, tifurac, tigecycline, tigemonam, emerid, SuXethonium, SuxibuZone, Symclosene, Synetine, tigestol, tigloidine, tillargenine, tiletamine, tilidine, tiliq tabilautide, tabimorelin, tacalcitol, tacapenem, tacedinaline, uinol, tilisolol, tilmacoxib, tilmicosin, tilnoprofen, tilomi taclamine, tacrine, tacrolimus, tadalafil, tafluposide, sole, tillorone, tilozepine, tilsuprost, tiludonic acid, timcodar, taglutamine, tagorizine, talampanel, talampicillin, talapor timefurone, timegadine, timelotem, timepidium, timiperone, fin, talastine, talbutal, taleranol, talibegron, talinolol, tal timirdine, timobesone acetate, timofibrate, timolol, timo ipexole, talisomycin, tallimustine, talmetacin, talmetoprim, nacic, timoprazole, tinabinol, tinazoline, tinidazole, tinisul talnetant, talniflumate, talopram, talsalate, toloXimine, tal pride, tinofedrine, tinoridine, tiocarlide, tioclomarol, tio saclidine, talsupram, taltirelin, taltobulin, taltrimide, talu conazole, tioctilate, tiodaZosin, tiodonium, tiomergine, dipine, talviraline, tameridone, tameticillin, tametraline, tiomesterone, tioperidone, tiopinate, tiopronin, tiopropam tamibarotene, tamitinol, tanolarizine, tamoxifen, tam ine, tioSpirone, tiotidine, tiotropium, tioxacin, tioXamast, pramine, tamsulosin, tanaproget, tandamine, tandospirone, tioxaprofen, tioxidazole, tioXolone, tipentosin, tipepidine, tandutinib, taniplon, tanomastat, tapentadol, taprizosin, tap tipetropium, tipifarnib, tipindole, tipranavir, tipredane, tipre US 2007/01 16729 A1 May 24, 2007 34 nolol, tiprinast, tiprodil, tiprostanide, tiportimod, tiqueside, tylosin, tymazolin, tyropanoate, tyrosine, tyrothricin, uben tiquinamide, tiquizium, tiracizine, tirapazamine, tiratricol, imex, ubidecarenone, ubisindine, ufenamate, ufiprazole, tirilazad, tirofiban, tiropramine, tisartan, tisocalcitate, uldazepam, ulifloxacin, uliprisnil, umespirone, undecylenic tisocromide, tisopurine, tisoquone, tivanidazole, tiviciclovir, acid, unoprostone, upenazime, upidosin, uracil, uracil mus tivirapine, tixadil, tixanox, tiXocortol, tiZabrin, tizanidine, tard, urapidil, uredepa, uredofos, urefibrate, ursodiol. tizolemide, tizoprolic acid, tobicillin, toborinone, tobramy urulcholic acid, utibapril, utibaprilat, Vadocaine, Valaciclo cin, tocainide, tocamphyl, tocladesine, tocofenoxate, tocofi Vir, Valconazole, Valdecoxib, Valdetamide, Valdipromide, brate, tocophersolan, todralazine, tofenacin, tofetridine, Valethamate, vlaganiciclovir, Valine, Valnemulin, Vlanocta tofimilast, tofisoline, tofisppam, tolafentrine, tolamolol. mide, valofane, valomaciclovir, Valperinol, Valproate, Vlap tolaZamide, tolboxane, tolbutamide, tolvapone, tolciclate, toldimfos, tolfamide, tolfenamic acid, tolgabide, tolimidone, roicacid, valpromide, Valrocemide, valrubicin, Valsartan, tolindate, toliodium, toliprolol, tolmesoxide, tometin, tolnaf Valorcitabine, Valtrate, Vamicamide, Vancomycin, Vandet tate, tolnapersine, tolnidamine, toloconium, tolonidine, tolo anib, Vaneprim, Vanitiolide, VanOXerine, Vanyldisulfamide, nium, toloxatone, toloxychlorinol, tolpadol, tolpentamide, vapiprost, Vapreotide, Vardenfanil, Varenicline, Varespladib, tolperisone, tolpiprazole, tolpronine, tolpropamide, tolpyr Vatalanib, Vatanidipine, Vebufloxacin, vecuronium, Vedacli ramide, tolduinzole, tolrestat, tolterodine, toltraZuril, tolu dine, Vedaprofen, Velaresol, Velnacrine, Venlafaxine, Venriti fazepam, tolvaptan, tolycaine, tomeglovir, tomelukast, dine, Verodoline, Veralipride, Verapamil, Verazide, Verilo tomoglumide, tomoxiprole, tonabersat, tonazocine, topiluta pam, Verlukast, Verofylline, versetamide, Verteporfin, mide, topiramate, topixantrone, topotecan, toprilidine, Vesnarinone, vestipitant, Vetrabutine, Vidarabine, vigabatrin, topterone, toguizine, torbafylline, torcetrapib, torcitabine, VilaZodone, Vildaglipin, Viloxazine, vinbarbital, vinblastine, toremifene, toripristone, torsemide, tosagestin, tosifen, to Su Vinburnine, Vincamine, Vincanol, Vincofos, Vinconate, Vin floxacin, to Sulur, trabectedin, traboXopine, tracazolate, cristine, Vindeburnol, Vindesine, Vinpidine, Vinflunine, Vin tradecamide, tralonide, tramadol, tramazoline, trandolapril, formide, Vinfosiltine, Vinglycinate, Vinleucinol, Vinleuro trandolaprilat, tranexamic acid, tranilast, transcainide, tran sine, Vinmegallate, Vinorelbine, vinpocetine, Vinpoline, telinium, tranycypromine, trapencaine, trapidil, travoprost, Vinrosidine, vintiamol, vintoperol, vintriptol, vinylbital, vin traxanox, traxoprodil, traZitiline, trazium, traZodone, tra Zolidine, viomycin, Viprostol, vidualine, Vicquidil, Virginia Zolopride, trebenzomine, trecadrine, trecetilide, trefentanil, mycin, Viridofulvin, ViroXime, Visnadine, Visnafylline, Vofo trelnarizine, treloxinate, trenbolone, trengestone, trenizine, pitant, Voglibose, volazocine, Volpristin, Voriconazole, treosulfan, trepibutone, trepipam, trepirium, treprostinil, Vorozole, Voxergolide, Xaliproden, Xamoterol, Xanomeline, treptilamine, terquisin, tresperimus, trestolone, trethinium, Xanoxic acid, Xanthinol. xantifibrate, Xantocillin, Xanto?yl trethocanoic acid, tretinoin, tretinoin tocoferil, tretoquinol, palmitate, Xemilofiban, Xenalipin, Xenazoic acid, Xenbucin, triacetin, triafungin, triamcinolone, triamcinolone acetonide, Xenipentone, Xenothiorate, Xenygloxal, Xenylhexenicacid, triamcinolone benetonide, triamcinolone furetonide, tri Xenylropium, Xibenolol, Xibornol. xidecaflur, Xilobam, ampyZine, triamternem triaziquone, triazolam, tribendilol. Ximelagatran, Ximoprofen, Xinidamine, Xinomiline, sipam tribenoside, tribromsalan, tribuZone, tricaprilin, tricetamide, ide, Xipranolol. Xorphanol, Xylamidine, Xylazine, Xylocou trichlorfon, trichlormethiazide, trichlomethine, triciribine, marol, Xylometazoline, Xyloxemine, yohimbic acid, Zab triclabendazole, triclacetamol, triclazate, triclobisonium, tri icipril, Zabiciprilat, Zacopride, Zafirlukast, Zafiuleptine, clocarban, triclodazol, triclofenol, triclofos, triclofyllin, tri Zalcitabine, Zalderide, Zaleplon, Zalospirone, Zalitidine, Zal clonide, triclosan, tricyclamol, tridihexethyl, tridolgosir, tri toprofen, Zamifenacin, Zanamivir, Zanapezil, Zankiren, Zan entine, triethylenemelamine, trifenagrel, trifeZolac, triflocin, oterone, Zapizolam, Zaprinast, Zardaverine, Zatebradine, triflubazam, triflumidate, triflomeprazine, trifluperazine, tri Zatosetron, Zelandopam, Zenarestat, Zenazocine, Zeniplatin, fluperidol, triflupromazine, trifluidine, triflusal, trifosmin, Zepastine, Zeranol, Zetidoline, Zidapamide, Zidometacin, trigevolol, trihexylpheidyl, triletide, triloStane, trimaZosin, Zidovudine, Zifrostilone, Zilantel, Zilascorb, Zileuton, Zil trimebutine, trimecain, trimedoxime, trimegestone, trimep paterol, Zimeldine, Zimidoben, Zindotrine, Zindoxifene, Zin eridine, trimeprazine, trimetazidine, trimethadone, trimetha conazole, Zinostatin, Zinterol, Zinviroxime, Zipeprol, Ziprsi mide, trimethaphan, trimethidinium, trimethobenzamide, done, Zocainone, Zofenopril. Zofenoprilat, Zoficonazole, trimethoprim, trimetozine, trimetrexZate, trimexiline, trimi Zolamine, Zolasartan, Zolazepam, Zolendronic acid, Zolen pramine, trimoprostil, trimoxamine, trioxifene, trioxsalen, Zepine, Zollertine, Zolimidine, Zoliprofen, Zolmitriptan, Zol tripalmitin, tripamide, triparanol, tripelennamine, triplatin, operone, Zolpidem, Zomebazam, Zomepirac, Zometapine, triprolidine, triptorelin, tritoqualine, trixolane, trizoxime, Zonampanel, Zoniclezole, Zoniporide, Zonisamide, Zopi trocimine, troclosene, trodusquemine, trofosfamide, trogli clone, Zopolrestat, Zorbamycin, Zorubicin, ZoSuquidar, taZone, troleandomycin, tromanttadine, tropabazate, tro Zotepine, Zoticasone, Zoxazolamine, Zucapsaicin, Zuclomi panserin, tropapride, tropatepine, tropenZiline, tropicamide, phene, Zuclopenthixol, Zylofuramine, and pharmaceutically tropigline, tropirine, tropisetron, tropodifene, troquidazole, acceptable salts, amides, Sulfonamides, amides, carbamates, trospectomycin, troSpium, trovafloxacin, troVirdine, troxac esters, and phosphoesters thereof, and amorphousand crys itabine, troXerutin, troXipide, troXolamide, troxonium, troxy talline forms of any of the foregoing, and anhydrate and pyrrolium, truXicurium, truXipicurium, tryparsamide, tub hydate and Solvate forms of any of the foregoing. ocurarine, tubulozole, tucaresol, tuclazepam, tulathromycin, tulobuterol, tulopafant, turosteride, tuvatidine, tybamate,