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Tri-Mag Supreme Powder™ High Dose Bioavailable Magnesium Powder

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Tri-Mag Supreme Powder™ High Dose Bioavailable Magnesium Powder Tri-Mag Supreme Powder ™ High dose bioavailable magnesium powder Tri-Mag Supreme PowderTM benefits: OVERVIEW • Maintains and supports energy levels This highly absorbable and bioavailable blend of three key forms • Aids in bone development and integrity of magnesium: Magnesium amino acid chelate, magnesium • Assists in healthy carbohydrate glycerophosphate and magnesium orotate. This product provides metabolism 350mg of magnesium in each serving. Due to this unique blend it should not cause any of the unfavourable gastrointestinal symptoms • Supports muscle function and relaxation that are sometimes associated with magnesium supplementation. • Reduces symptoms of premenstrual tension • Helps to convert carbohydrates into KEY FEATURES: energy Magnesium is an essential mineral that serves as an enzyme • Supports metabolic rate cofactor for over three hundred biochemical reactions in the body, including those of glycolysis, the first step in harnessing energy from carbohydrates. Magnesium follows potassium as the second most abundant intracellular cation (positively charged electrolyte) in the body. The adult human body contains approximately 25 grams of magnesium, over 60% of which is found in the skeleton. Muscle tissue contains about 27%, with the bulk of the balance found in other intracellular areas, and less than 1% occurring in the blood.3 As a structural component of the hydroxyapatite mineral matrix of bone, a natural calcium channel blocker, muscle relaxant, facilitator of calming effects upon the nervous system, and a required element for electrolyte balance and proper functioning of sodium-potassium pumps, magnesium plays a crucial role in supporting physical strength and mobility, muscle contraction, neurological health, cardiac function, and psychological balance. Magnesium’s role as an enzyme cofactor for processes that generate ATP underlies its importance for maintaining energy levels and metabolic deficiency.2 Magnesium Amino Acid Chelate A highly absorbable form of elemental magnesium chelated to an amino acid. The amino acid chelate is absorbed via dipeptide channels, bypassing the usual active transport and passive diffusion routes for intestinal ion absorption, where magnesium would otherwise compete with other minerals. This method of delivery allows larger amounts of magnesium to be absorbed more quickly and be better retained by the body, as compared to many other forms. Moreover, the breaking of the bonds between magnesium and the amino acid allows the body to use both the mineral and the amino acids, making this a more physiologically natural and nutritionally beneficial process than other chelated mineral delivery mechanisms, such as EDTA. The magnesium-amino acid complex protects magnesium from binding to dietary phytates and tannins, therefore enhancing its bioavailability. This unique form of magnesium has been shown to be effective for individuals with the greatest impairments in magnesium absorption, including those with inflammatory bowel conditions, among whom the prevalence of overt magnesium deficiency may be as high as 86%.1,2 © 2019 Designs for Health Pty Ltd FOR PROFESSIONAL REFERENCE ONLY designsforhealth.com.au Tri-Mag Supreme Powder™ High dose bioavailable magnesium powder Magnesium Amino Acid Chelate cont. Compared to healthy subjects, those with compromised intestinal mineral absorption excrete twice as much magnesium when given in insoluble salt form (such as Mg oxide), as opposed to a chelate. This amino acid chelate may be especially beneficial for those who require high doses of magnesium, as relatively high doses lead to fewer unwanted gastrointestinal effects that may present with other forms of supplementation. Chelated magnesium has been shown to reduce the pain associated with dysmenorrhea and the frequency and severity of leg cramps in pregnant women. Magnesium Glycerophosphate Magnesium glycerophosphate (MgGy) is a combined source of magnesium and phosphorus. It has a high magnesium content, 12.5%, higher than other organic salts such as lactate, gluconate, and citrate. MgGy is the magnesium salt ∂ and ß isomeric monoglycerophosphoric acid. This salt is one of the most bioavailable and well tolerated salts.8 In addition to being a source of magnesium, MgGy is also a source of phosphorus. Studies have demonstrated that glycerophosphate anion can be employed as a reliable phosphorus source for both cell growth and recombinant protein production.9 Glycerophosphate is a key intermediate in the synthesis of phospholipids. Phospholipids are the main constituent of biological membranes. The size, shape, charge, and chemical composition of different phospholipid classes play a role in the formation and maintenance of the plasma membrane bilayer of cells, as well as membranes surrounding subcellular organelles and vesicles. An asymmetric10 distribution of phospholipid types within the membrane imparts different functional characteristics between the inner and outer leaflets. Phospholipids are involved in stabilising proteins within the membrane, facilitating the active conformational structure of proteins, and as cofactors in enzymatic reactions. Phospholipids are essential for the absorption, transport and storage of lipids. They have long been known to be critical components of various cellular processes. Through the creation of knockout mice, phospholipid biosynthesis has been shown to influence the development of several chronic diseases, such as atherosclerosis and cardiovascular disease, steatohepatitis, muscular dystrophy and diabetes. Glycerophosphate or glycerol 3-phosphate is the starting molecule in the biosynthesis of phosphatidic acid, which forms the backbone on which the synthesis of other phospholipid species and triacylglycerol is based.10 Clinical studies indicate that MgGy could have health benefits as it is more readily assimilated and digested by the body than other magnesium salts (gluconate, aspartate, citrate). Consequently, MgGy is an effective magnesium supplement for patients suffering from magnesium deficiency and/or malabsorption. MgGy has a beneficial effect on the cardiovascular system. Thus, it can be used as a treatment in order to decrease ventricular ectopy. Furthermore, MgGy is a powerful muscle relaxant power.13 Magnesium Orotate Magnesium Orotate (MO) is a magnesium salt of Orotic Acid (OA) is poorly soluble in water and hence does not bid to gastric acid or does it exhibit laxative effects upon oral administration in contrast to easily dissociable Mg salts. OA acts as a transporter that carries magnesium into the cells and is shown to improve the energy status of injured myocardium by stimulating the synthesis of glycogen and ATP. OA also exhibits antioxidant properties, since it is a key intermediate in the biosynthetic pathway of pyrimidines that promotes the synthesis of enzymes which act as free radical scavengers. Experiments investigating the potential cardioprotective actions of orotic acid in pathological heart conditions are still ongoing. Myocardial energy-rich phosphate levels are decreased during hypoxic conditions; subsequently, intracellular Mg is depleted and lost via the urine.11 Since binding sites for Mg (ATP) are provided by OA it can be classified as "Mg-fixing agent". Accordingly, MO is also indicated for the treatment of Mg depletion as convincingly shown in animal experiments and also in coronary heart patients undergoing e.g. aortocoronary bypass surgery.1,2,3 B Vitamins and Co-factors Activated B vitamins support the actions of magnesium in this formula. As a group, the B vitamins are essential to the respiratory chain involved in ATP synthesis. This range of nutrients may assist in minimising the systemic effects of stress. Glutamine is a nutrient with an impressive range of health benefits. It helps balance blood sugar, builds lean muscle, and strengthen the body’s defenses. Taurine is a sulfur-containing amino acid that plays many roles in promoting proper heart function, immune function, glucose metabolism, and nervous system health. Taurine is one of the most important nutrients for promoting heart health. It strengthens the heart muscle and plays a major role in regulating the heart’s contractility. Taurine also acts as a natural diuretic by keeping potassium and magnesium inside cells and keeping excess sodium out. Such mineral balance is crucial for heart vitality and overall wellness. © 2019 Designs for Health Pty Ltd FOR PROFESSIONAL REFERENCE ONLY designsforhealth.com.au Tri-Mag Supreme Powder™ High dose bioavailable magnesium powder Acetyl L-Carnitine Acetyl L-carnitine is one of the most extensively researched brain nutrients with a proven ability to enhance mental energy and wellness. Research shows acetyl L-carnitine: 1. Energises the brain 2. Increases levels of important neurotransmitter chemicals needed for memory, focus, and learning 3. Repairs the damage done to brain cells caused by stress and poor nutrition Acetyl L-carnitine is a natural component of our brain's chemistry. The body makes it in small amounts. As we age, acetyl L-carnitine levels decline. For optimal brain function, supplementing acetyl L-carnitine is highly recommended. The only food source for this nutrient is animal brain, which is not a recommended food. Supplemental acetyl L-carnitine, on the other hand, is synthetically derived from other amino acids, and is suitable for vegetarians.12 ACTIVE INGREDIENTS PER 5 GRAM SERVE: Magnesium (from orotate dihydrate) 101 mg Mecobalamin (co-methylcobalamin) 150 activated vit B12 micrograms Magnesium
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