Tri-Mag Supreme™ Bioavailable Magnesium Capsule

Tri-Mag Supreme™ Bioavailable magnesium capsule

Tri-Mag SupremeTM benefits: OVERVIEW • Maintains and supports energy levels This highly absorbable and bioavailable blend of three key forms • Aids in bone development and integrity of magnesium: Magnesium amino acid chelate, magnesium glycerophosphate and magnesium orotate. This product provides • Assists in healthy carbohydrate 150 mg of magnesium in each serving. Due to this unique blend it metabolism should not cause any of the unfavourable gastrointestinal symptoms • Supports muscle function and relaxation that are sometimes associated with magnesium supplementation. • Reduces symptoms of premenstrual tension KEY FEATURES: Magnesium is an essential mineral that serves as an enzyme • Helps to convert carbohydrates into cofactor for over three hundred biochemical reactions in the body, energy including those of glycolysis, the first step in harnessing energy • Supports metabolic rate from carbohydrates. Magnesium follows potassium as the second most abundant intracellular cation (positively charged electrolyte) in the body. The adult human body contains approximately 25 grams of magnesium, over 60% of which is found in the skeleton. Muscle tissue contains about 27%, with the bulk of the balance found in other intracellular areas, and less than 1% occurring in the blood.3 As a structural component of the hydroxyapatite mineral matrix of bone, a natural calcium channel blocker, muscle relaxant, facilitator of calming effects upon the nervous system, and a required element for electrolyte balance and proper functioning of sodium-potassium pumps, magnesium plays a crucial role in supporting physical strength and mobility, muscle contraction, neurological health, cardiac function, and psychological balance. Magnesium’s role as an enzyme cofactor for processes that generate ATP underlies its importance for maintaining energy levels and metabolic deficiency.2

Magnesium Amino Acid Chelate A highly absorbable form of elemental magnesium chelated to an amino acid. The amino acid chelate is absorbed via dipeptide channels, bypassing the usual active transport and passive diffusion routes for intestinal ion absorption, where magnesium would otherwise compete with other minerals. This method of delivery allows larger amounts of magnesium to be absorbed more quickly and be better retained by the body, as compared to many other forms. Moreover, the breaking of the bonds between magnesium and the amino acid allows the body to use both the mineral and the amino acids, making this a more physiologically natural and nutritionally beneficial process than other chelated mineral delivery mechanisms, such as EDTA. The magnesium-amino acid complex protects magnesium from binding to dietary phytates and tannins, therefore enhancing its bioavailability. This unique form of magnesium has been shown to be effective for individuals with the greatest impairments in magnesium absorption, including those with inflammatory bowel conditions, among whom the prevalence of overt magnesium deficiency may be as high as 86%.1,2

Magnesium Amino Acid Chelate cont. Compared to healthy subjects, those with compromised intestinal mineral absorption excrete twice as much magnesium when given in insoluble salt form (such as Mg oxide), as opposed to a chelate. This amino acid chelate may be especially beneﬁcial for those who require high doses of magnesium, as relatively high doses lead to fewer unwanted gastrointestinal effects that may present with other forms of supplementation. Chelated magnesium has been shown to reduce the pain associated with dysmenorrhea and the frequency and severity of leg cramps in pregnant women.

Magnesium Glycerophosphate Magnesium glycerophosphate (MgGy) is a combined source of magnesium and phosphorus. It has a high magnesium content, 12.5%, higher than other organic salts such as lactate, gluconate, and citrate. MgGy is the magnesium salt ∂ and ß isomeric monoglycerophosphoric acid. This salt is one of the most bioavailable and well tolerated salts.8 In addition to being a source of magnesium, MgGy is also a source of phosphorus. Studies have demonstrated that glycerophosphate anion can be employed as a reliable phosphorus source for both cell growth and recombinant protein production.9 Glycerophosphate is a key intermediate in the synthesis of phospholipids. Phospholipids are the main constituent of biological membranes. The size, shape, charge, and chemical composition of different phospholipid classes play a role in the formation and maintenance of the plasma membrane bilayer of cells, as well as membranes surrounding subcellular organelles and vesicles. An asymmetric10 distribution of phospholipid types within the membrane imparts different functional characteristics between the inner and outer leaflets. Phospholipids are involved in stabilising proteins within the membrane, facilitating the active conformational structure of proteins, and as cofactors in enzymatic reactions. Phospholipids are essential for the absorption, transport and storage of lipids. They have long been known to be critical components of various cellular processes. Through the creation of knockout mice, phospholipid biosynthesis has been shown to influence the development of several chronic diseases, such as atherosclerosis and cardiovascular disease, steatohepatitis, muscular dystrophy and diabetes. Glycerophosphate or glycerol 3-phosphate is the starting molecule in the biosynthesis of phosphatidic acid, which forms the backbone on which the synthesis of other phospholipid species and triacylglycerol is based.10 Clinical studies indicate that MgGy could have health benefits as it is more readily assimilated and digested by the body than other magnesium salts (gluconate, aspartate, citrate). Consequently, MgGy is an effective magnesium supplement for patients suffering from magnesium deficiency and/or malabsorption. MgGy has a beneficial effect on the cardiovascular system. Thus, it can be used as a treatment in order to decrease ventricular ectopy. Furthermore, MgGy is a powerful muscle relaxant power.

Magnesium Orotate Magnesium Orotate (MO) is a magnesium salt of Orotic Acid (OA) is poorly soluble in water and hence does not bid to gastric acid or does it exhibit laxative effects upon oral administration in contrast to easily dissociable Mg salts. OA acts as a transporter that carries magnesium into the cells and is shown to improve the energy status of injured myocardium by stimulating the synthesis of glycogen and ATP. OA also exhibits antioxidant properties, since it is a key intermediate in the biosynthetic pathway of pyrimidines that promotes the synthesis of enzymes which act as free radical scavengers. Experiments investigating the potential cardioprotective actions of orotic acid in pathological heart conditions are still ongoing. Myocardial energy-rich phosphate levels are decreased during hypoxic conditions; subsequently, intracellular Mg is depleted and lost via the urine. Since binding sites for Mg (ATP) are provided by OA it can be classiﬁed as "Mg-ﬁxing agent". Accordingly, MO is also indicated for the treatment of Mg depletion as convincingly shown in animal experiments and also in coronary heart patients undergoing e.g. aortocoronary bypass surgery.1-3

ACTIVE INGREDIENTS PER CAPSULE: EXCIPIENT INGREDIENTS:

Magnesium (from amino acid chelate) 140 mg - Magnesium stearate - Hypromellose Magnesium (from orotate) 5 mg - Puriﬁed water Magnesium (from glycerophosphate) 5 mg - Carrageenan Total magnesium 150 mg - Pectin DOES NOT CONTAIN THE FOLLOWING: PACK SIZE:

Gluten, dairy, lactose, seeds or nuts. 60 per bottle. DIRECTIONS FOR USE:

Take 1 capsule per day, or as directed by your healthcare professional.

Designed, encapsulated & packed in Australia from local and imported ingredients.

PRESCRIBING INFORMATION: > Magnesium is contraindicated in patients with renal failure or heart block (unless a pace maker is present). > Individuals with Myasthenia gravis should avoid the use of magnesium supplements. > Concurrent use of magnesium with the use of ﬂuroquinolone antibiotics may reduce the absorption of the medication, while tetracycline antibiotics may form an insoluble complex with magnesium therefore it is advisable to take these medications at least 2 hours before or 4 hours after magnesium intake. > Concurrent use of magnesium with calcium channel blockers or anti arrhythmic medications may potentiate hypotensive or anti arrhythmic activity. Monitor patient.

WARNINGS: > If symptoms persist consult your healthcare practitioner. > Vitamin supplements should not replace a balanced diet.

HIGHLIGHTED PROPRIETARY/SPECIAL INGREDIENTS: GIVOMAG™ is a highly bioavailable source of magnesium. GIVOMAG™ is magnesium bound by a glycerophosphate anion. This forms a chelate, which means that the magnesium is bound at two points instead of forming just one bond. This is important because this type of bond protects magnesium throughout digestion. Many magnesium supplements are not absorbed by the body. GIVOMAG™ provides a bioavailable source of magnesium. As an added bonus, the glycerophosphate anion provides the body with multiple health beneﬁts. One of the main obstacles when supplementing with magnesium is diarrhoea. Typically, when magnesium reaches the GI tract, it pulls water into the intestines. This is due to the nature of the magnesium cation: on its own, it can hydrate itself up to 400 times its own dehydrated radius. The hydrated molecule is then too large to pass through the intestine into the bloodstream. This phenomenon happens when magnesium is unbound from its side molecule. Chelated magnesium compounds are more stable throughout the GI tract and avoids this hydration. This allows magnesium to become absorbed, instead of passing through the body as waste.12

REFERENCES 1. Elin RJ. Magnesium metabolism in health and disease. Dis Mon. 1988 Apr;34(4):161-218. 2. Jahnen-Dechent, Wilhelm and Ketteler, Markus. Magnesium basics. Clin Kidney J (2012) 5 [Suppl1]: i3–i14. 3. Linus Pauling Institute Micronutrient Information Center. Magnesium. Oregon State University. Updated 2013. 4. Seibrecht, Stefan. Magnesium bisglycinate as safe form for mineral supplementation in human nutrition. International Journal of Orthomolecular and Related Medicine. 2013, no 144 p.2-16. 5. Schuette SA, Lashner BA, Janghorbani M. Bioavailability of magnesium diglycinate vs magnesium oxide in patients with ileal resection. JPEN J Parenter Enteral Nutr. 1994 Sep-Oct;18(5):430-5. 6. Supakatisant C, Phupong V. Oral magnesium for relief in pregnancy-induced leg cramps: a randomised controlled trial. Matern Child Nutr. 2012 Aug 22. 7. Abraham GE. Primary dysmenorrhea. Clin Obstet Gynecol. 1978 Mar;21(1):139-45. 8. Corjon, G., 2012. www.acteur-nature.com. [Online] Available at: http://www.acteur-nature.com/les-nutriments-naturels/le-magnesium-dans-tous-sesetats.html 9. Zhang & al, 2006. Glycerophosphate as a phosphorus source in a deﬁned medium for Pichia pastoris fermentation. Appl Microbiol Biotechnol, pp. 139-144. 10. Kelly, K. & Jacobs, R., 2011. Phospholipid Biosynthesis. [Online] Available at: http://lipidlibrary.aocs.org/Biochemistry/content.cfm?ItemNumber=39191 11. Classen HG Magnesium orotate--experimental and clinical evidence. Rom J Intern Med. 2004;42(3):491-501. 12. glycerophosphate science. www.givomag.com.