CHAPTER TEN “Addicted to Euphoria”: The History, Clinical Presentation, and Management of Party Drug Misuse Jenny Bearn*,†,1, Matthew O'Brien* *Addictions Clinical Academic Group, South London and Maudsley NHS Foundation Trust, Maudsley Hospital, London, United Kingdom †Institute of Psychiatry, Psychology and Neuroscience, King’s College, London, United Kingdom 1Corresponding author: e-mail address:
[email protected] Contents 1. Historical Aspects of Party Drug Use 206 1.1 3,4-Methylenedioxymethamphetamine 206 1.2 γ-Hydroxybutyric Acid 208 1.3 Ketamine 210 2. Epidemiology of Party Drug Use 211 3. Recreational Use Versus Dependence 212 4. Party Drugs: Subjective Effects and Hazards of use 214 4.1 MDMA (Ecstasy) 214 4.2 GHB and GBL 218 4.3 Ketamine 223 5. The Future of Party Drugs 228 References 228 Abstract Eating, drinking, sexual activity, and parenting invoke pleasure, an emotion that pro- motes repetition of these behaviors, are essential for survival. Euphoria, a feeling or state of intense excitement and happiness, is an amplification of pleasure, aspired to one's essential biological needs that are satisfied. People use party drugs as a shortcut to euphoria. Ecstasy (3,4- methylenedioxymethamphetamine), γ-hydroxybutyric acid, and ketamine fall under the umbrella of the term “party drugs,” each with differing neuropharmacological and physiological actions. This chapter seeks to survey the history and epidemiology of party drug use; we will then discuss the pharmacological characteristics of each drug to provide a platform for understanding the difficulties that party drug users encounter through intoxication, harmful use, dependence, and withdrawal and how these should be clinically managed.