Post-Caesarean Surgical Site Infection: an Incidence and Associated Determinants Study at Kiryandongo General Hospital
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POST-CAESAREAN SURGICAL SITE INFECTION: AN INCIDENCE AND ASSOCIATED DETERMINANTS STUDY AT KIRYANDONGO GENERAL HOSPITAL BY FRED ABDON NAIBEI BMS/0029/141/DF A RESEARCH DISSERTATION SUBMITTED TO THE FACULTY OF CLINICAL MEDICNE AND DENTISTRY IN PARTIAL FULFILMENT FOR THE AWARD OF BACHELOR OF MEDICINE AND SURGERY AT KAMPALA INTERNATIONAL UNIVERSITY APRIL, 2019 0 LIST OF FIGURES ....................................................................................................................... iv LIST OF TABLES .......................................................................................................................... v DECLARATION ........................................................................................................................... vi APPROVAL ................................................................................................................................. vii ACKNOWLEDGEMENT ........................................................................................................... viii LIST OF ABBREVIATIONS AND ACRONYMS ...................................................................... ix OPERATIONAL DEFINITIONS ................................................................................................... x ABSTRACT ................................................................................................................................... xi CHAPTER ONE: INTRODUCTION ............................................................................................ 1 1.0. BACKGROUND ................................................................................................................. 1 1.1. PROBLEM STATEMENT .................................................................................................. 2 1.2. STUDY OBJECTIVES ........................................................................................................ 3 1.2.1. BROAD OBJECTIVE ...................................................................................................... 3 1.3.2. SPECIFIC OBJECTIVES ..................................................................................................... 3 1.3. RESEARCH QUESTIONS ................................................................................................. 3 1.4. SIGNIFICANCE OF THE STUDY..................................................................................... 3 1.5. STUDY SCOPE ................................................................................................................... 4 1.6.1. GEOGRAPHICAL SCOPE .................................................................................................. 4 1.6.2. CONTENT SCOPE .............................................................................................................. 4 1.6.3. TIME SCOPE ....................................................................................................................... 4 1.7. CONCEPTUAL FRAMEWORK ............................................................................................ 4 CHAPTER TWO: LITERATURE REVIEW ................................................................................. 6 2.0. INTRODUCTION ................................................................................................................... 6 2.1. INCIDENCE OF POST-CAESAREAN SURGICAL SITE INFECTION ............................. 6 2.2. RISK FACTORS FOR POST-CAESAREAN SURGICAL SITE INFECTIONS .................. 7 2.3. OUTCOMES OF POST-CAESAREAN SURGICAL SITE INFECTION ............................. 8 CHAPTER THREE: METHODOLOGY ....................................................................................... 9 3.0. INTRODUCTION ............................................................................................................... 9 3.1. STUDY DESIGN..................................................................................................................... 9 3.2. STUDY POPULATION .......................................................................................................... 9 i 3.2.1. INCLUSION CRITERIA...................................................................................................... 9 3.2.2. EXCLUSION CRITERIA .................................................................................................... 9 3.3. SAMPLE SIZE DETERMINATION ...................................................................................... 9 3.4. SAMPLING TECHNIQUE ..................................................................................................... 9 3.5. DATA COLLECTION METHOD .......................................................................................... 9 3.6. DATA COLLECTION TOOLS AND PROCEDURE .......................................................... 10 3.7. QUALITY CONTROL .......................................................................................................... 10 3.8. DATA ANALYSIS ................................................................................................................ 10 3.9. ETHICAL CONSIDERATIONS ........................................................................................... 10 CHAPTER FOUR: STUDY FINDINGS ..................................................................................... 11 4.0. INTRODUCTION ............................................................................................................. 11 4.1. PREVALENCE OF POST-CAESAREAN SURGICAL SITE INFECTION ....................... 11 4.2. FACTORS ASSOCIATED WITH POST-CS SSIs ............................................................... 11 4.2.1. HOST RELATED FACTORS ASSOCIATED WITH POST-CS SSIs (N=40) ................ 11 4.2.2. PREGNANCY-RELATED FACTORS ASSOCIATED WITH POST-CS SSIs (N=40) .. 12 4.2.3. NATURE OF CAESAREAN SECTION AS A FACTOR IN POST-CS SSIs (N=40) ..... 13 4.3. OUTCOMES/COMPLICATIONS FOLLOWING POST-CS SSIs (N=40) ......................... 13 CHAPTER FIVE: DISCUSSION, CONCLUSION AND RECOMMENDATIONS .................. 15 5.0. INTRODUCTION ............................................................................................................. 15 5.1. DISCUSSIONS ...................................................................................................................... 15 5.1.1. PREVALENCE OF POST-CS SURGICAL SITE INFECTIONS ..................................... 15 5.1.2. FACTORS ASSOCIATED WITH POST-CS SSIs ............................................................ 15 5.1.3. OUTCOMES/COMPLICATIONS OF POST-CS SSIs ...................................................... 16 5.2. CONCLUSIONS.................................................................................................................... 16 5.3. RECOMMENDATIONS ....................................................................................................... 17 REFERENCES ............................................................................................................................. 18 APPENDICES .............................................................................................................................. 22 APPENDIX ONE: CONSENT FORM ......................................................................................... 22 APPENDIX TWO: CHECKLIST................................................................................................. 23 APPENDIX THREE: MAP OF UGANDA SHOWING THE LOCATION OF KIRYANDONGO DISTRICT (RED ARROW & RED INSET) ............................................................................... 25 ii APPENDIX FOUR: APPROVAL LETTER ................................................................................ 26 iii LIST OF FIGURES Figure 1: Conceptual Framework on risk factors for Post-Caesarean Surgical Site Infections; Researcher’s view ........................................................................................................................... 5 Figure 2: Pregnancy-related risk factors to Post-CS SSIs (N=40) ................................................ 12 Figure 3: Nature of Caesarean Section and Prevalence of SSIs (N=40)....................................... 13 Figure 4: Complications of SSIs (N=40) ...................................................................................... 14 iv LIST OF TABLES Table 1: Host-related risk factors for post-CS SSIs (N=40) ......................................................... 12 v DECLARATION I hereby declare that this research dissertation is the product of my own efforts and to the best of my knowledge and conviction, has never been presented to any institution for any award or qualification whatsoever. Wherever the works of other people have been included, due acknowledgement to this has been made in accordance with the appropriate referencing and citations. The findings and the analysis that will result from this research project will be my original information. Researcher: FRED ABDON NAIBEI, BMS/0029/141/DF Signature ……………………………………………... Date ………………………………………………...…. vi APPROVAL This is to certify that this research dissertation has been prepared under my supervision and has never been presented anywhere for any other purpose and is now ready for submission to the Faculty of Clinical Medicine and Dentistry of Kampala International University for further consideration. Supervisor: DR. JOHNIE MULWANA, CONSULTANT OBSTETRICIAN AND GYNECOLOGIST Signed…………………………………………………. Date……………………………………………….…… vii ACKNOWLEDGEMENT I would like to thank Father God Almighty,