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2017 MS Research Update Is Made Possible Through Contributions in Honor Of: Dr MAY 2017 RESEARCH MS UPDATE Written and compiled by Michelle Fabian, MD and Stephen Krieger, MD Includes additional material by MS Margaret M. McCormick, RN, BSN, MSCN RESEARCH Reviewed by Jack Burks, MD UPDATE Edited by Susan Courtney MSAA’s 2017 edition of the MS Research Update provides important new data on approved and experimental treatments for MS, and is a valuable resource to the entire MS community. Please note that this update gives an overview of the research behind the approved and experimental medications and therapies for the long-term treatment of multiple sclerosis. It does not include information on any symptom-management medications or therapies. For additional information about MS, symptoms and symptom management, as well as MSAA’s programs and services, please visit mymsaa.org or call (800) 532-7667. Questions to MSAA’s Client Services department may also be emailed to [email protected]. Additionally, please note that due to the timing of the national and international MS conferences, study data from the 2017 conferences could not be included in this writing. Information in this publication includes data presented at the 2016 conferences, as well as any important updates that occurred in early 2017. Please visit MSAA’s website at mymsaa.org for future summaries of 2017 conference highlights. The 2017 MS Research Update is made possible through contributions in honor of: Dr. Jules Kernan and Ms. Hannah Dennehy Lee and an anonymous supporter Multiple Sclerosis Association of America National Headquarters website: mymsaa.org 375 Kings Highway North toll-free phone: (800) 532-7667 Cherry Hill, New Jersey 08034 email: [email protected] CONTENTS Introduction ............................................................................................2 FDA-APPROVED MEDICATIONS New Data Ocrevus® (ocrelizumab) ........................................................................6 Zinbryta® (daclizumab)..........................................................................7 Tysabri® (natalizumab) ..........................................................................9 The Multiple Sclerosis Association Gilenya® (fingolimod)..........................................................................10 of America (MSAA) is a leading resource for the entire MS EXPERIMENTAL MEDICATIONS community, improving lives today through vital services and support. Administered Orally ® Laquinimod (also known as Nerventra ) ..........................................11 MSAA publications are intended to inform and educate those with Monoclonal Antibodies MS and their families. MSAA does Rituxan® (rituximab)..............................................................................13 ® not endorse or recommend any Ofatumumab (also known as Arzerra )..............................................14 specific products, services, therapies, or activities mentioned New S1P Receptor Modulators in articles or advertisements that Siponimod (BAF312) ..........................................................................15 appear in MSAA publications. Ozanimod (formerly RPC1063) ..........................................................16 MSAA, its staff, and those affiliated Ponesimod ............................................................................................17 with the writing of this publication cannot be held responsible for Other Th erapeutic Strategies any unintentional errors. Masitinib (also known as Kinavet® and Masivet®) ............................18 Ibudilast ................................................................................................18 ™ ® MSAA strives to provide useful, Tcelna (formerly Tovaxin ) ................................................................19 up-to-date information on matters Tetracycline Antibiotics........................................................................20 of concern to MS patients and Statins ....................................................................................................20 their families. This material is intended for general New Therapies under Investigation..................................................21 informational purposes only, and it does not constitute medical NEW DIRECTIONS IN MS RESEARCH advice. You should not use the information presented as a means New Therapeutic Approaches of diagnosis or for determining Vitamins and Electrolytes ....................................................................26 treatment. For diagnosis and Vitamin D3 ......................................................................................26 treatment options, you are urged Lipoic Acid ......................................................................................28 to consult your physician. Biotin (MD1003) ............................................................................28 Stem Cells ............................................................................................29 Copyright © Multiple Sclerosis Biomarkers ............................................................................................32 Association of America, 2017. All Genetic Studies ....................................................................................34 rights reserved. No part of this The Microbiome and MS ....................................................................36 publication may be reproduced, Diet and MS ..........................................................................................37 stored in a retrieval system, or Salt ..................................................................................................37 transmitted in any form or by any means, electronic, mechanical, Closing Notes ......................................................................................39 photocopying, recording, or otherwise, without prior written Chart: Approved Long-Term Treatments for MS ............................40 permission from MSAA. References ............................................................................................44 1 MS RESEARCH UPDATE Written and compiled by Michelle Fabian, MD and Stephen Krieger, MD Includes additional material by Margaret M. McCormick, RN, BSN, MSCN Reviewed by Jack Burks, MD Edited by Susan Courtney INTRODUCTION course, there is nonetheless far too much This year’s MS Research Update has been ongoing research in MS therapeutics for all of designed to highlight numerous experimental it to be covered here. This is therefore not a drugs currently under investigation for the complete list, and not all study results could long-term treatment of multiple sclerosis (MS), be included. to provide new clinical trial data on some of This information is based on a wide the already-approved disease-modifying range of sources, including extensive journal therapies (DMTs), and to describe the most literature on MS and its management, a exciting new areas of MS research. Please note review of ongoing clinical trials, and papers that in order to keep this annual MS Research presented at major national and international Update current and up to date, historical conferences. These include the 2016 background and completed trials of approved conferences hosted by the American DMTs are no longer included. Academy of Neurology (AAN), the This 2017 edition of MSAA’s MS Research Consortium of Multiple Sclerosis Centers Update is again being printed as a stand- (CMSC), and the Americas and European alone issue, reflecting the incredible diversity Committees for Treatment and Research in and scope of research progress in MS. Of Multiple Sclerosis (ACTRIMS and ECTRIMS). 2 MS RESEARCH UPDATE 2017 In 2016, experts from member points and incorporate more commonly used organizations of the Multiple Sclerosis terminology. In addition, the summary is Coalition (MSC), including the Multiple followed by an extensive glossary to assist Sclerosis Association of America (MSAA), with those terms specific to describing the MS collaborated to develop and update a process. This paper on the approved DMTs is 2014 paper that summarized the current a valuable counterpart to this MS Research evidence that supports the FDA-approved Update, which is focused on summarizing new DMTs for the long-term treatment of and emerging data covering available multiple sclerosis. The objectives were to therapies as well as emerging treatments still provide evidence for the effectiveness of in development. This paper for the MS these medications and to provide support community may be accessed by going to for broad access to these approved mymsaa.org/msc-dmt-summary. therapies for people with MS in the United Please note that the authors of this MS States. Ultimately, the goal is to enable Research Update have reported on the most individuals with MS and their medical recent study results available at the time of professionals to select the most appropriate publication. While every effort has been medication available. made to provide meaningful, timely, and This professional paper, titled “The Use balanced information on each medication, of Disease-Modifying Therapies in Multiple keeping the length of information equal for Sclerosis: Principles and Current Evidence,” each medication is not possible. Please know is available on MSAA’s website for anyone that the different lengths of text should in no to review. It has been written expressly way be considered as favoritism toward any for medical professionals, in a highly one product. Additionally, references have detailed and scientific
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