International Journal of Integrated Care – ISSN 1568-4156 Volume 10, 29 January 2010 URL: http://www.ijic.org Publisher: Igitur, Utrecht Publishing & Archiving Services Copyright: Section on Conceptual Bases of Person-centered Medicine The person and philosophy of science and medicine Kenneth F. Schaffner, MD, PhD, University Professor of History and Philosophy of Science, Professor of Psychiatry, University of Pittsburgh, Pittsburgh, USA Correspondence to: Kenneth Schaffner, E-mail:
[email protected],
[email protected] This article addresses three perspectives from which to view the person in personalized and person-centered medi- cine and psychiatry. The first considers the particular person’s body, with a focus on pharmacogenomic advances in understanding individual variation both in drug metabolism (e.g. CYP genotyping) as well as in dopamine and receptor polymorphisms. The second part of the talk considers the particular person’s ‘mind’—as a complex nar- rative of life plans, experiences, responses, and family and social contexts, and how philosophy has characterized and interpreted the person seeking psychiatric help. The article concludes with an exploration of how the first two perspectives can best be philosophically integrated for the whole particularized individual, and considers how the tools and resources of the World Psychiatric Association Institutional Program on Psychiatry for the Person (IPPP) might assist this integration. Before approaching these three perspectives, we first need to be clear about the several senses in which ‘person- alized medicine’ may be used. There seem to be two somewhat overlapping senses that will concern us in this paper. The first, and most broadly accepted but also the more restrictive sense, identifies personalized medicine with individualized medicine—and is focused on largely genetic individual variation.