PCDHA5 Monoclonal Antibody (M01A), Clone

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PCDHA5 Monoclonal Antibody (M01A), Clone

PCDHA5 monoclonal antibody demonstrate an unusual genomic organization similar to (M01A), clone 1E8 that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin Catalog Number: H00056143-M01A superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related Regulation Status: For research use only (RUO) coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream Product Description: Mouse monoclonal antibody C-terminal exons, or constant exons, which are shared raised against a partial recombinant PCDHA5. by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains Clone Name: 1E8 while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion Immunogen: PCDHA5 (NP_061731, 183 a.a. ~ 289 proteins are integral plasma membrane proteins that a.a) partial recombinant protein with GST tag. MW of the most likely play a critical role in the establishment and GST tag alone is 26 KDa. function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional Sequence: variants have been suggested but their full-length nature TNEEETNFLELVLRKSLDREETQEHRLLVIATDGGKPE has yet to be determined. [provided by RefSeq] LTGTVQLLINVLDANDNAPEFDKSIYNVRLLENAPSGTL VIKLNASDADEGINKEIVYFFSNLVLDDVK Host: Mouse Reactivity: Human Applications: ELISA, WB-Ce, WB-Re (See our web site product page for detailed applications information) Protocols: See our web site at http://www.abnova.com/support/protocols.asp or product page for detailed protocols Isotype: IgM Kappa Storage Buffer: In ascites fluid Storage Instruction: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. Entrez GeneID: 56143 Gene Symbol: PCDHA5 Gene Alias: CNR6, CNRN6, CNRS6, CRNR6, PCDH-ALPHA5 Gene Summary: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that Page 1/1 Powered by TCPDF (www.tcpdf.org).

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Supplementary Table 1: Adhesion Genes Data Set
Supplementary Table 1: Adhesion genes data set PROBE Entrez Gene ID Celera Gene ID Gene_Symbol Gene_Name 160832 1 hCG201364.3 A1BG alpha-1-B glycoprotein 223658 1 hCG201364.3 A1BG alpha-1-B glycoprotein 212988 102 hCG40040.3 ADAM10 ADAM metallopeptidase domain 10 133411 4185 hCG28232.2 ADAM11 ADAM metallopeptidase domain 11 110695 8038 hCG40937.4 ADAM12 ADAM metallopeptidase domain 12 (meltrin alpha) 195222 8038 hCG40937.4 ADAM12 ADAM metallopeptidase domain 12 (meltrin alpha) 165344 8751 hCG20021.3 ADAM15 ADAM metallopeptidase domain 15 (metargidin) 189065 6868 null ADAM17 ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) 108119 8728 hCG15398.4 ADAM19 ADAM metallopeptidase domain 19 (meltrin beta) 117763 8748 hCG20675.3 ADAM20 ADAM metallopeptidase domain 20 126448 8747 hCG1785634.2 ADAM21 ADAM metallopeptidase domain 21 208981 8747 hCG1785634.2|hCG2042897 ADAM21 ADAM metallopeptidase domain 21 180903 53616 hCG17212.4 ADAM22 ADAM metallopeptidase domain 22 177272 8745 hCG1811623.1 ADAM23 ADAM metallopeptidase domain 23 102384 10863 hCG1818505.1 ADAM28 ADAM metallopeptidase domain 28 119968 11086 hCG1786734.2 ADAM29 ADAM metallopeptidase domain 29 205542 11085 hCG1997196.1 ADAM30 ADAM metallopeptidase domain 30 148417 80332 hCG39255.4 ADAM33 ADAM metallopeptidase domain 33 140492 8756 hCG1789002.2 ADAM7 ADAM metallopeptidase domain 7 122603 101 hCG1816947.1 ADAM8 ADAM metallopeptidase domain 8 183965 8754 hCG1996391 ADAM9 ADAM metallopeptidase domain 9 (meltrin gamma) 129974 27299 hCG15447.3 ADAMDEC1 ADAM-like,
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Identification of Gene Modules Associated with Warfarin Dosage by a Genome-Wide DNA Methylation Study
ORIGINAL ARTICLES Department of Clinical Pharmacology1, Xiangya Hospital, Institute of Clinical Pharmacology2, Central South University, Hunan Key Laboratory of Pharmacogenetics; Changsha; Department of Cardio-Thoracic Surgery3, the Second Xiangya Hospital of Central South University, Changsha; Key Laboratory of Bio-resources and Eco-environment4 (Ministry of Education), College of Life Science, Sichuan University, Chengdu, China Identification of gene modules associated with warfarin dosage by a genome-wide DNA methylation study ZHIYING LUO1, 2, RONG LIU1, 2, BAO SUN1, 2, XINMING ZHOU3, ZHAOQIAN LIU1, 2, HONGHAO ZHOU1, 2, HENG XU4, XI LI1,2,*,#, WEI ZHANG1,2,*,# Received December 12, 2017, accepted January 10, 2018 *Corresponding authors: Prof. Wei Zhang, Xi Li, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 110 Xiangya Rode, Kaifu district, Changsha, Hunan 410008, China [email protected]; [email protected] #Wei Zhang and Xi Li contributed equally to this study. Pharmazie 73: 288–293 (2018) doi: 10.1691/ph.2018.7319 Objective: To identify warfarin dose-associated DNA methylation changes, we conducted the first genomewide DNA methylation association study. Method: A total of 22 patients who required an extreme warfarin dosage from VKORC1 -1639AA & CYP2C9*1*1 genotype group were enrolled in this study. The Illumina Infinium Human- Methylation450 platform was used to perform genome-scale DNA methylation profiling, identifying differentially methylated CpG sites by a nonparametric test. WGCNA was used to analyze the association between gene modules and extreme warfarin dosage. Results: For a total of 378,313 CpG sites that passed the quality control processes, we identified eight differentially methylated CpG probes (p<0.05) showing altered DNA methylation level (>20%) between two extreme dose groups.
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Whole Exome Sequencing Reveals NOTCH1 Mutations in Anaplastic Large Cell Lymphoma and Points to Notch Both As a Key Pathway and a Potential Therapeutic Target
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UC San Diego UC San Diego Electronic Theses and Dissertations
UC San Diego UC San Diego Electronic Theses and Dissertations Title Insights from reconstructing cellular networks in transcription, stress, and cancer Permalink https://escholarship.org/uc/item/6s97497m Authors Ke, Eugene Yunghung Ke, Eugene Yunghung Publication Date 2012 Peer reviewed|Thesis/dissertation eScholarship.org Powered by the California Digital Library University of California UNIVERSITY OF CALIFORNIA, SAN DIEGO Insights from Reconstructing Cellular Networks in Transcription, Stress, and Cancer A dissertation submitted in the partial satisfaction of the requirements for the degree Doctor of Philosophy in Bioinformatics and Systems Biology by Eugene Yunghung Ke Committee in charge: Professor Shankar Subramaniam, Chair Professor Inder Verma, Co-Chair Professor Web Cavenee Professor Alexander Hoffmann Professor Bing Ren 2012 The Dissertation of Eugene Yunghung Ke is approved, and it is acceptable in quality and form for the publication on microfilm and electronically ________________________________________________________________ ________________________________________________________________ ________________________________________________________________ ________________________________________________________________ Co-Chair ________________________________________________________________ Chair University of California, San Diego 2012 iii DEDICATION To my parents, Victor and Tai-Lee Ke iv EPIGRAPH [T]here are known knowns; there are things we know we know. We also know there are known unknowns; that is to say we know there
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Fibroblasts from the Human Skin Dermo-Hypodermal Junction Are
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Role of the Chromosome Architectural Factor SMCHD1 in X-Chromosome Inactivation, Gene Regulation, and Disease in Humans
HIGHLIGHTED ARTICLE | INVESTIGATION Role of the Chromosome Architectural Factor SMCHD1 in X-Chromosome Inactivation, Gene Regulation, and Disease in Humans Chen-Yu Wang,*,† Harrison Brand,‡,§,**,†† Natalie D. Shaw,‡‡,§§ Michael E. Talkowski,‡,§,**,†† and Jeannie T. Lee*,†,1 *Department of Molecular Biology, ††Center for Human Genetic Research, and ‡‡Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, †Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, ‡Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, §Program in Medical and Population Genetics and **Center for Mendelian Genomics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, §§National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 ORCID IDs: 0000-0002-3912-5113 (C.-Y.W.); 0000-0001-7786-8850 (J.T.L.) ABSTRACT Structural maintenance of chromosomes flexible hinge domain-containing 1 (SMCHD1) is an architectural factor critical for X-chromosome inactivation (XCI) and the repression of select autosomal gene clusters. In mice, homozygous nonsense mutations in Smchd1 cause female-specific embryonic lethality due to an XCI defect. However, although human mutations in SMCHD1 are associated with congenital arhinia and facioscapulohumeral muscular dystrophy type 2 (FSHD2), the diseases do not show a sex- specific bias, despite the essential nature of XCI in humans. To investigate whether there is a dosage imbalance for the sex chromo- somes, we here analyze transcriptomic data from arhinia and FSHD2 patient blood and muscle cells. We find that X-linked dosage compensation is maintained in these patients. In mice, SMCHD1 controls not only protocadherin (Pcdh) gene clusters, but also Hox genes critical for craniofacial development.
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The Pdx1 Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet Β Cell
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Functional Test of PCDHB11, the Most Human-Specific Neuronal Surface Protein Guilherme Braga De Freitas, Rafaella Araújo Gonçalves and Matthias Gralle*
de Freitas et al. BMC Evolutionary Biology (2016) 16:75 DOI 10.1186/s12862-016-0652-x RESEARCHARTICLE Open Access Functional test of PCDHB11, the most human-specific neuronal surface protein Guilherme Braga de Freitas, Rafaella Araújo Gonçalves and Matthias Gralle* Abstract Background: Brain-expressed proteins that have undergone functional change during human evolution may contribute to human cognitive capacities, and may also leave us vulnerable to specifically human diseases, such as schizophrenia, autism or Alzheimer’s disease. In order to search systematically for those proteins that have changed the most during human evolution and that might contribute to brain function and pathology, all proteins with orthologs in chimpanzee, orangutan and rhesus macaque and annotated as being expressed on the surface of cells in the human central nervous system were ordered by the number of human-specific amino acid differences that are fixed in modern populations. Results: PCDHB11, a beta-protocadherin homologous to murine cell adhesion proteins, stood out with 12 substitutions and maintained its lead after normalizing for protein size and applying weights for amino acid exchange probabilities. Human PCDHB11 was found to cause homophilic cell adhesion, but at lower levels than shown for other clustered protocadherins. Homophilic adhesion caused by a PCDHB11 with reversion of human- specific changes was as low as for modern human PCDHB11; while neither human nor reverted PCDHB11 adhered to controls, they did adhere to each other. A loss of function in PCDHB11 is unlikely because intra-human variability did not increase relative to the other human beta-protocadherins. Conclusions: The brain-expressed protein with the highest number of human-specific substitutions is PCDHB11.
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Gwas Meta-Analysis of Intelligence 1
bioRxiv preprint doi: https://doi.org/10.1101/184853; this version posted September 6, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. GWAS META-ANALYSIS OF INTELLIGENCE 1 GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence Jeanne E Savage1#, Philip R Jansen1,2#, Sven Stringer1, Kyoko Watanabe1, Julien Bryois3, Christiaan A de Leeuw1, Mats Nagel1, Swapnil Awasthi4, Peter B Barr5, Jonathan R I Coleman6,7, Katrina L Grasby8, Anke R Hammerschlag1, Jakob Kaminski4,9, Robert Karlsson3, Eva Krapohl6, Max Lam10, Marianne Nygaard11,12, Chandra A Reynolds13, Joey W Trampush14, Hannah Young15, Delilah Zabaneh6, Sara Hägg3, Narelle K Hansell16, Ida K Karlsson3, Sten Linnarsson17, Grant W Montgomery8,18, Ana B Muñoz-Manchado17, Erin B Quinlan6, Gunter Schumann6, Nathan Skene17, Bradley T Webb19,20,21, Tonya White2, Dan E Arking22, Deborah K Attix23,24, Dimitrios Avramopoulos22,25, Robert M Bilder26, Panos Bitsios27, Katherine E Burdick28,29,30, Tyrone D Cannon31, Ornit Chiba-Falek32, Andrea Christoforou23, Elizabeth T Cirulli33, Eliza Congdon26, Aiden Corvin34, Gail Davies35, 36, Ian J Deary35,36, Pamela DeRosse37, Dwight Dickinson38, Srdjan Djurovic39,40, Gary Donohoe41, Emily Drabant Conley42, Johan G Eriksson43,44, Thomas Espeseth45,46, Nelson A Freimer26, Stella Giakoumaki47, Ina Giegling48, Michael Gill34, David
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Name Aliases Binding Partner Physiology / Oncology References
Name Aliases Binding partner Physiology / Oncology References AJAP1 Adherens junction associated protein 1, ? PHY : Expressed in uterus and pancreas. [1] http://www.uniprot.org/uniprot/Q9UKB5. [2] SHREW1 Plays a role in cell adhesion and migration. McDonald JM, Cancer Biol Ther 2006, 5:300-4 Forms a complex with CDH1 and beta-catenin at adherens junctions [1] ONC : Frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration [2] ALCAM Activated leukocyte cell adhesion CD6 PHY : Adhesion of activated leukocytes and [1] Ofori-Acquah SF, Transl Res 2008, 151:122- molecule, CD166, MEMD (melanoma neurons 8. [2] van Kilsdonk JW, Cancer Res 2008, metastasis clone D) 68:3671-9 ONC : Expressed by different tumor types including melanoma; mediates cancer/ melanoma invasiveness [1,2] AMICA1 Adhesion molecule interacting with CXADR PHY : Expression is restricted to the [1] http://www.uniprot.org/uniprot/Q86YT9. [2] CXADR antigen 1, JAML (junctional hematopoietic tissues with the exception of Moog-Lutz C, Blood 2003, 102:3371-8 adhesion molecule-like) liver. May function in transmigration of leukocytes through epithelial and endothelial tissues. Mediates adhesive interactions with CXADR, a protein of the junctional complex of epithelial cells [1] ONC : Enhances myeloid leukemia cell adhesion to endothelial cells [2] AMIGO1 Amphoterin-induced gene and open AMIGO PHY : May be involved in fasciculation as well [1] http://www.uniprot.org/uniprot/Q86WK6 reading frame 1, Alivin-2 as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain [1] ONC : - AMIGO2 Amphoterin-induced gene and open AMIGO PHY : Highest levels in breast, ovary, cervix, [1] http://www.uniprot.org/uniprot/Q86SJ2.
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