Anti-HRK (Middle Region) Polyclonal Antibody (CPBT-66330RH) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-HRK (middle region) polyclonal antibody (CPBT-66330RH) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview This product detects Harakiri (HRK), also known as DP5. HRK is a BH3 only protein of the Bcl-2 family, which promotes Bax dependent apoptosis. HRK regulates apoptosis through its interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL, and in conjunction to the mitochondrial pore forming protein p32. HRK is thought to have a specific role in initiating neuronal and haematopoietic cell apoptosis, in particular to growth factor deprivation. Aberrant methylation of HRK is frequently detected in primary colorectal cancers. Despite its predicted molecular weight, HRK often migrates at 12-15kD. Western Blotting detects a band of approximately 13kDa in mouse pancreas tissue lysate.

Specificity HRK

Immunogen 15 amino acid peptide from near the centre of human HRK (NP_003797).

Isotype IgG

Source/Host Rabbit

Species Reactivity Human, Mouse, Rat

Conjugate Unconjugated

Applications WB

Format Purified IgG - liquid

Size 100 μg

Preservative See individual product datasheet

Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

Warnings For research purposes only

GENE INFORMATION

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Official Symbol HRK

Synonyms HRK; harakiri, BCL2 interacting protein; DP5; HARAKIRI; activator of apoptosis harakiri; death protein 5; BCL2-interacting protein; activator of apoptosis Hrk; neuronal death protein DP5; BH3- interacting domain-containing protein 3; harakiri, BCL2 interac

Entrez Gene ID 8739

Protein Refseq NP_003797

UniProt ID O00198

Chromosome Location 12q24.22

Pathway ATF-2 transcription factor network; Apoptosis; Apoptosis Modulation and Signaling;

Function protein binding;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]