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529 Part 582—Substances Generally Recognized As

529 Part 582—Substances Generally Recognized As

Food and Drug Administration, HHS Pt. 582

(a) Energy sources. Ionizing radiation 582.1057 Hydrochloric acid. is limited to gamma rays from sealed 582.1061 Lactic acid. units of cobalt-60. 582.1069 Malic acid. (b) Limitation. The ionizing radiation 582.1073 Phosphoric acid. 582.1077 Potassium acid tartrate. is used for feed or feed ingredients that 582.1087 Sodium acid pyrophosphate. do not contain drugs. 582.1091 Succinic acid. (c) Use. Ionizing radiation is used as 582.1095 Sulfuric acid. a single treatment for rendering com- 582.1099 Tartaric acid. plete poultry diets or poultry feed in- 582.1125 Aluminum sulfate. gredients salmonella negative as fol- 582.1127 Aluminum ammonium sulfate. lows: 582.1129 Aluminum potassium sulfate. 582.1131 Aluminum sodium sulfate. (1) Minimum dose 2.0 kiloGrays (kGy) 582.1135 Ammonium bicarbonate. (0.2 megarad (Mrad)); maximum dose 25 582.1137 Ammonium carbonate. kGy (2.5 megarads Mrad). The absorbed 582.1139 Ammonium hydroxide. dose of irradiation is to be based on ini- 582.1141 Ammonium phosphate. tial concentration of salmonella using 582.1143 Ammonium sulfate. the relationship that 1.0 kGy (0.1 Mrad) 582.1155 Bentonite. reduces salmonella concentration by 582.1165 Butane. 582.1191 carbonate. one log cycle (one decimal reduction). 582.1193 . (2) Feeds treated by irradiation 582.1195 Calcium citrate. should be formulated to account for 582.1199 . nutritional loss. 582.1205 Calcium hydroxide. (3) If an irradiated feed ingredient is 582.1207 . less than 5 percent of the final product, 582.1210 . the final product can be irradiated 582.1217 Calcium phosphate. 582.1235 Caramel. without being considered to be re- 582.1240 Carbon dioxide. irradiated. 582.1275 Dextrans. [60 FR 50099, Sept. 28, 1995] 582.1320 Glycerin. 582.1324 Glyceryl monostearate. 582.1355 Helium. PART 582—SUBSTANCES 582.1366 Hydrogen peroxide. GENERALLY RECOGNIZED AS SAFE 582.1400 Lecithin. 582.1425 Magnesium carbonate. Subpart A—General Provisions 582.1428 Magnesium hydroxide. 582.1431 Magnesium oxide. Sec. 582.1480 Methylcellulose. 582.1 Substances that are generally recog- 582.1500 Monoammonium glutamate. nized as safe. 582.1516 Monopotassium glutamate. 582.10 Spices and other natural seasonings 582.1540 Nitrogen. and flavorings. 582.1585 Papain. 582.20 Essential oils, oleoresins (solvent- 582.1613 Potassium bicarbonate. free), and natural extractives (including 582.1619 Potassium carbonate. distillates). 582.1625 . 582.30 Natural substances used in conjunc- 582.1631 Potassium hydroxide. tion with spices and other natural 582.1643 Potassium sulfate. seasonings and flavorings. 582.1655 Propane. 582.40 Natural extractives (solvent-free) 582.1666 Propylene glycol. used in conjunction with spices, 582.1685 Rennet. seasonings, and flavorings. 582.1711 Silica aerogel. 582.50 Certain other spices, seasonings, es- 582.1721 Sodium acetate. sential oils, oleoresins, and natural ex- 582.1736 Sodium bicarbonate. tracts. 582.1742 Sodium carbonate. 582.60 Synthetic flavoring substances and 582.1745 Sodium carboxymethylcellulose. adjuvants. 582.1748 Sodium caseinate. 582.80 Trace minerals added to animal feeds. 582.1751 Sodium citrate. 582.99 Adjuvants for pesticide chemicals. 582.1763 Sodium hydroxide. 582.1775 Sodium pectinate. Subpart B—General Purpose Food 582.1778 Sodium phosphate. Additives 582.1781 Sodium aluminum phosphate. 582.1792 Sodium sesquicarbonate. 582.1005 Acetic acid. 582.1804 Sodium potassium tartrate. 582.1009 Adipic acid. 582.1810 Sodium tripolyphosphate. 582.1033 . 582.1901 Triacetin.

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582.1973 Beeswax. 582.5159 Biotin. 582.1975 Bleached beeswax. 582.5191 . 582.1978 Carnauba wax. 582.5195 Calcium citrate. 582.5201 Calcium glycerophosphate. Subpart C—Anticaking Agents 582.5210 Calcium oxide. 582.5212 Calcium pantothenate. 582.2122 Aluminum calcium silicate. 582.5217 Calcium phosphate. 582.2227 Calcium silicate. 582.5223 Calcium pyrophosphate. 582.2437 Magnesium silicate. 582.5230 Calcium sulfate. 582.2727 Sodium aluminosilicate. 582.5245 Carotene. 582.2729 Hydrated sodium calcium 582.5250 Choline bitartrate. aluminosilicate. 582.5252 Choline chloride. 582.2906 Tricalcium silicate. 582.5260 Copper gluconate. 582.5271 Cysteine. Subpart D—Chemical 582.5273 Cystine. 582.5301 Ferric phosphate. 582.3013 Ascorbic acid. 582.5304 Ferric pyrophosphate. 582.3021 Benzoic acid. 582.5306 Ferric sodium pyrophosphate. 582.3041 Erythorbic acid. 582.5308 Ferrous gluconate. 582.3081 Propionic acid. 582.5311 Ferrous lactate. 582.3089 Sorbic acid. 582.5315 Ferrous sulfate. 582.3109 Thiodipropionic acid. 582.5361 Histidine. 582.3149 Ascorbyl palmitate. 582.5370 Inositol. 582.3169 Butylated hydroxyanisole. 582.5375 Iron reduced. 582.3173 Butylated hydroxytoluene. 582.5381 Isoleucine. 582.3189 Calcium ascorbate. 582.5406 Leucine. 582.3221 Calcium propionate. 582.5411 Lysine. 582.3225 Calcium sorbate. 582.5431 Magnesium oxide. 582.3280 Dilauryl thiodipropionate. 582.5434 Magnesium phosphate. 582.3336 Gum guaiac. 582.5443 Magnesium sulfate. 582.3490 Methylparaben. 582.5446 Manganese chloride. 582.3616 Potassium bisulfite. 582.5449 Manganese citrate. 582.3637 Potassium metabisulfite. 582.5452 Manganese gluconate. 582.3640 Potassium sorbate. 582.5455 Manganese glycerophosphate. 582.3660 Propyl gallate. 582.5458 Manganese hypophosphite. 582.3670 Propylparaben. 582.5461 Manganese sulfate. 582.3731 Sodium ascorbate. 582.5464 Manganous oxide. 582.3733 Sodium benzoate. 582.5470 Mannitol. 582.3739 Sodium bisulfite. 582.5475 Methionine. 582.3766 Sodium metabisulfite. 582.5477 Methionine hydroxy analog and its 582.3784 Sodium propionate. 582.3795 Sodium sorbate. calcium salts. 582.3798 Sodium sulfite. 582.5530 Niacin. 582.3845 Stannous chloride. 582.5535 Niacinamide. 582.3862 Sulfur dioxide. 582.5580 D-Pantothenyl alcohol. 582.3890 Tocopherols. 582.5590 Phenylalanine. 582.5622 . Subpart E—Emulsifying Agents 582.5628 Potassium glycerophosphate. 582.5634 Potassium iodide. 582.4101 Diacetyl tartaric acid esters of 582.5650 Proline. mono- and diglycerides of edible fats or 582.5676 Pyridoxine hydrochloride. oils, or edible fat-forming fatty acids. 582.5695 Riboflavin. 582.4505 Mono- and diglycerides of edible 582.5697 Riboflavin-5-phosphate. fats or oils, or edible fat-forming acids. 582.5701 Serine. 582.4521 derivatives 582.5772 Sodium pantothenate. of mono- and diglycerides of edible fats 582.5778 Sodium phosphate. or oils, or edible fat-forming fatty acids. 582.5835 Sorbitol. 582.4666 Propylene glycol. 582.5875 Thiamine hydrochloride. 582.5878 Thiamine mononitrate. Subpart F—Nutrients and/or Dietary 582.5881 Threonine. Supplements 582.5890 Tocopherols. 582.5892 a-Tocopherol acetate. 582.5013 Ascorbic acid. 582.5915 Tryptophane. 582.5017 Aspartic acid. 582.5920 Tyrosine. 582.5049 Aminoacetic acid. 582.5925 Valine. 582.5065 Linoleic acid. 582.5930 Vitamin A. 582.5118 Alanine. 582.5933 Vitamin A acetate. 582.5145 Arginine. 582.5936 Vitamin A palmitate.

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582.5945 Vitamin B12. as safe for their intended use. However, 582.5950 Vitamin D2. by way of illustration, the Commis- 582.5953 Vitamin D3. sioner regards such common food in- 582.5985 Zinc chloride. 582.5988 . gredients as salt, pepper, sugar, vin- 582.5991 Zinc oxide. egar, baking powder, and monosodium 582.5994 Zinc stearate. glutamate as safe for their intended 582.5997 Zinc sulfate. use. The lists in subparts B through H of this part include additional sub- Subpart G—Sequestrants stances that, when used for the pur- 582.6033 Citric acid. poses indicated, in accordance with 582.6085 Sodium acid phosphate. good manufacturing or feeding prac- 582.6099 Tartaric acid. tice, are regarded by the Commissioner 582.6185 Calcium acetate. as generally recognized as safe for such 582.6193 Calcium chloride. 582.6195 Calcium citrate. uses. 582.6197 Calcium diacetate. (b) For the purposes of this section, 582.6199 Calcium gluconate. good manufacturing or feeding practice 582.6203 Calcium hexametaphosphate. shall be defined to include the fol- 582.6215 Monobasic calcium phosphate. lowing restrictions: 582.6219 Calcium phytate. 582.6285 Dipotassium phosphate. (1) The quantity of a substance added 582.6290 Disodium phosphate. to animal food does not exceed the 582.6386 Isopropyl citrate. amount reasonably required to accom- 582.6511 Monoisopropyl citrate. plish its intended physical, nutritional, 582.6625 Potassium citrate. or other technical effect in food; and 582.6751 Sodium citrate. 582.6754 Sodium diacetate. (2) The quantity of a substance that 582.6757 Sodium gluconate. becomes a component of animal food as 582.6760 Sodium hexametaphosphate. a result of its use in the manufac- 582.6769 Sodium metaphosphate. turing, processing, or packaging of 582.6778 Sodium phosphate. food, and which is not intended to ac- 582.6787 Sodium pyrophosphate. complish any physical or other tech- 582.6789 Tetra sodium pyrophosphate. nical effect in the food itself, shall be 582.6801 Sodium tartrate. 582.6804 Sodium potassium tartrate. reduced to the extent reasonably pos- 582.6807 Sodium thiosulfate. sible. 582.6810 Sodium tripolyphosphate. (3) The substance is of appropriate 582.6851 Stearyl citrate. grade and is prepared and handled as a food ingredient. Upon request the Com- Subpart H—Stabilizers missioner will offer an opinion, based 582.7115 Agar-agar. on specifications and intended use, as 582.7133 Ammonium alginate. to whether or not a particular grade or 582.7187 Calcium alginate. lot of the substance is of suitable pu- 582.7255 Chondrus extract. rity for use in food and would generally 582.7330 Gum arabic. 582.7333 Gum ghatti. be regarded as safe for the purpose in- 582.7339 Guar gum. tended, by experts qualified to evaluate 582.7343 Locust bean gum. its safety. 582.7349 Sterculia gum. (c) The inclusion of substances in the 582.7351 Gum tragacanth. list of nutrients does not constitute a 582.7610 Potassium alginate. finding on the part of the Department 582.7724 Sodium alginate. that the substance is useful as a sup- AUTHORITY: 21 U.S.C. 321, 342, 348, 371. plement to the diet for animals. SOURCE: 41 FR 38657, Sept. 10, 1976, unless (d) Substances that are generally rec- otherwise noted. ognized as safe for their intended use within the meaning of section 409 of Subpart A—General Provisions the Act are listed in subparts B through H of this part. When the status § 582.1 Substances that are generally of a substance has been reevaluated recognized as safe. and affirmed as GRAS or deleted from (a) It is impracticable to list all sub- subparts B through H of this part, an stances that are generally recognized appropriate explanation will be noted,

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e.g., ‘‘affirmed as GRAS,’’ ‘‘food addi- tion, pending a specific review of such tive regulation,’’ ‘‘interim food addi- other uses. tive regulation,’’ or ‘‘prohibited from use in food,’’ with a reference to the § 582.10 Spices and other natural appropriate new regulation. Such nota- seasonings and flavorings. tion will apply only to the specific use Spices and other natural seasonings covered by the review, e.g., direct ani- and flavorings that are generally rec- mal food use and/or indirect animal ognized as safe for their intended use, food use and/or animal feed use and within the meaning of section 409 of will not affect its status for other uses the act, are as follows: not specified in the referenced regula-

Common name Botanical name of plant source

Alfalfa herb and seed ...... Medicago sativa L. Allspice ...... Pimenta officinalis Lindl. Ambrette seed ...... Hibiscus abelmoschus L. Angelica ...... Angelica archangelica L. or other spp. of Angelica. Angelica root ...... Do. Angelica seed ...... Do. Angostura (cusparia bark) ...... Galipea officinalis Hancock. Anise ...... Pimpinella anisum L. Anise, star ...... Illicium verum Hook. f. Balm ( balm) ...... Melissa officinalis L. Basil, bush ...... Ocimum minimum L. Basil, sweet ...... Ocimum basilicum L. Bay ...... Laurus nobilis L. Calendula ...... Calendula officinalis L. Camomile (chamomile), English or Roman ...... Anthemis nobilis L. Camomile (chamomile), German or Hungarian ...... Matricaria chamomilla L. Capers ...... Capparis spinosa L. Capsicum ...... Capsicum frutescens L. or Capsicum annuum L. Caraway ...... Carum carvi L. Caraway, black (black cumin) ...... Nigella sativa L. Cardamom (cardamon) ...... Elettaria cardamomum Maton. Cassia, Chinese ...... Cinnamomum cassia Blume. Cassia, Padang or Batavia ...... Cinnamomum burmanni Blume. Cassia, Saigon ...... Cinnamomum loureirii Nees. Cayenne pepper ...... Capsicum frutescens L. or Capsicum annuum L. Celery seed ...... Apium graveolens L. Chervil ...... Anthriscus cerefolium (L.) Hoffm. Chives ...... Allium schoenoprasum L. Cinnamon, Ceylon ...... Cinnamomum zeylanicum Nees. Cinnamon, Chinese ...... Cinnamomum cassia Blume. Cinnamon, Saigon ...... Cinnamomum loureirii Nees. Clary (clary sage) ...... Salvia sclarea L. Clover ...... Trifolium spp. Cloves ...... Eugenia caryophyllata Thunb. Coriander ...... Coriandrum sativum L. Cumin (cummin) ...... Cuminum cyminum L. Cumin, black (black caraway) ...... Nigella sativa L. Dill ...... Anethum graveolens L. Elder flowers ...... Sambucus canadensis L. Fennel, common ...... Foeniculum vulgare Mill. Fennel, sweet (finocchio, Florence fennel) ...... Foeniculum vulgare Mill. var. duice (DC.) Alex. Fenugreek ...... Trigonella foenum-graecum L. Galanga (galangal) ...... Alpina officinarum Hance. Garlic ...... Allium sativum L. Geranium ...... Pelargonium spp. Ginger ...... Zingiber officinale Rosc. Glycyrrhiza ...... Glycyrrhiza glabra L. and other spp. of Glycyrrhiza. Grains of paradise ...... Amomum melegueta Rosc. Horehound (hoarhound) ...... Marrubium vulgare L. Horseradish ...... Armoracia lapathifolia Gilib. Hyssop ...... Hyssopus officinalis L. Lavender ...... Lavandula officinalis Chaix. Licorice ...... Glycyrrhiza glabra L. and other spp. of Glycyrrhiza. Linden flowers ...... Tilia spp. Mace ...... Myristica fragrans Houtt. Marigold, pot ...... Calendula officinalis L. Marjoram, pot ...... Majorana onites (L.) Benth. Marjoram, sweet ...... Majorana hortensis Moench. Mustard, black or brown ...... Brassica nigra (L.) Koch.

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Common name Botanical name of plant source

Mustard, brown ...... Brassica juncea (L.) Coss. Mustard, white or yellow ...... Brassica hirta Moench. Nutmeg ...... Myristica fragrans Houtt. Oregano (oreganum, Mexican oregano, Mexican sage, origan) Lippia spp. Paprika ...... Capsicum annuum L. Parsley ...... Petroselinum crispum (Mill.) Mansf. Pepper, black ...... Piper nigrum L. Pepper, cayenne ...... Capsicum frutescens L. or Capsicum annuum L. Pepper, red ...... Do. Pepper, white ...... Piper nigrum L. Peppermint ...... Mentha piperita L. Poppy seed ...... Papaver somniferum L. Pot marigold ...... Calendula officinalis L. Pot marjoram ...... Majorana onites (L.) Benth. Rosemary ...... Rosmarinus officinalis L. Rue ...... Ruta graveolens L. Saffron ...... Crocus sativus L. Sage ...... Salvia officinalis L. Sage, Greek ...... Salvia triloba L. Savory, summer ...... Satureia hortensis L. (Satureja). Savory, winter ...... Satureia montana L. (Satureja). Sesame ...... Sesamum indicum L. Spearmint ...... Mentha spicata L. Star anise ...... Illicium verum Hook. f. Tarragon ...... Artemisia dracunculus L. Thyme ...... Thymus vulgaris L. Thyme, wild or creeping ...... Thymus serpyllum L. Turmeric ...... Curcuma longa L. Vanilla ...... Vanilla planifolia Andr. or Vanilla tahitensis J. W. Moore. Zedoary ...... Curcuma zedoaria Rosc.

§ 582.20 Essential oils, oleoresins (sol- ing distillates) that are generally rec- vent-free), and natural extractives ognized as safe for their intended use, (including distillates). within the meaning of section 409 of Essential oils, oleoresins (solvent- the act, are as follows: free), and natural extractives (includ-

Common name Botanical name of plant source

Alfalfa ...... Medicago sativa L. Allspice ...... Pimenta officinalis Lindl. Almond, bitter (free from prussic acid) ...... Prunus amygdalus Batsch, Prunus armeniaca L. or Prunus persica (L.) Batsch. Ambrette (seed) ...... Hibiscus moschatus Moench. Angelica root ...... Angelica archangelica L. Angelica seed ...... Do. Angelica stem ...... Do. Angostura (cusparia bark) ...... Galipea officinalis Hancock. Anise ...... Pimpinella anisum L. Asafetida ...... Ferula assa-foetida L. and related spp. of Ferula. Balm (lemon balm) ...... Melissa officinalis L. Balsam of Peru ...... Myroxylon pereirae Klotzsch. Basil ...... Ocimum basilicum L. Bay leaves ...... Laurus nobilis L. Bay (myrcia oil) ...... Pimenta racemosa (Mill.) J. W. Moore. Bergamot (bergamot ) ...... aurantium L. subsp. bergamia Wright et Arn. Bitter almond (free from prussic acid) ...... Prunus amygdalus Batsch, Prunus armeniaca L., or Prunus persica (L.) Batsch. Bois de rose ...... Aniba rosaeodora Ducke. Cacao ...... Theobroma cacao L. Camomile (chamomile) flowers, Hungarian ...... Matricaria chamomilla L. Camomile (chamomile) flowers, Roman or English ...... Anthemis nobilis L. Cananga ...... Cananga odorata Hook. f. and Thoms. Capsicum ...... Capsicum frutescens L. and Capsicum annuum L. Caraway ...... Carum carvi L. Cardamom seed (cardamon) ...... Elettaria cardamomum Maton. Carob bean ...... Ceratonia siliqua L. Carrot ...... Daucus carota L. Cascarilla bark ...... Croton eluteria Benn. Cassia bark, Chinese ...... Cinnamomum cassia Blume.

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Common name Botanical name of plant source

Cassia bark, Padang or Batavia ...... Cinnamomum burmanni Blume. Cassia bark, Saigon ...... Cinnamomum loureirii Nees. Celery seed ...... Apium graveolens L. Cherry, wild, bark ...... Prunus serotina Ehrh. Chervil ...... Anthriscus cerefolium (L.) Hoffm. Chicory ...... Cichorium intybus L. Cinnamon bark, Ceylon ...... Cinnamomum zeylanicum Nees. Cinnamon bark, Chinese ...... Cinnamomum cassia Blume. Cinnamon bark, Saigon ...... Cinnamomum loureirii Nees. Cinnamon leaf, Ceylon ...... Cinnamomum zeylanicum Nees. Cinnamon leaf, Chinese ...... Cinnamomum cassia Blume. Cinnamon leaf, Saigon ...... Cinnamomum loureirii Nees. Citronella ...... Cymbopogon nardus Rendle. Citrus peels ...... Citrus spp. Clary (clary sage) ...... Salvia sclarea L. Clove bud ...... Eugenia caryophyllata Thunb. Clove leaf ...... Do. Clove stem ...... Do. Clover ...... Trifolium spp. Coca (decocainized) ...... Erythroxylum coca Lam. and other spp. of Erythroxylum. Coffee ...... Coffea spp. Cola nut ...... Cola acuminata Schott and Endl., and other spp. of Cola. Coriander ...... Coriandrum sativum L. Corn silk ...... Zea mays L. Cumin (cummin) ...... Cuminum cyminum L. Curacao orange peel (orange, bitter peel) ...... Citrus aurantium L. Cusparia bark ...... Galipea officinalis Hancock. Dandelion ...... Taraxacum officinale Weber and T. laevigatum DC. Dandelion root ...... Do. Dill ...... Anethum graveolens L. Dog grass (quackgrass, triticum) ...... Agropyron repens (L.) Beauv. Elder flowers ...... Sambucus canadensis L. and S. nigra L. Estragole (esdragol, esdragon, tarragon) ...... Artemisia dracunculus L. Estragon (tarragon) ...... Do. Fennel, sweet ...... Foeniculum vulgare Mill. Fenugreek ...... Trigonella foenum-graecum L. Galanga (galangal) ...... Alpinia officinarum Hance. Garlic ...... Allium sativum L. Geranium ...... Pelargonium spp. Geranium, East Indian ...... Cymbopogon martini Stapf. Geranium, rose ...... Pelargonium graveolens L’Her. Ginger ...... Zingiber officinale Rosc. Glycyrrhiza ...... Glycyrrhiza glabra L. and other spp. of Glycyrrhiza. Glycyrrhizin, ammoniated ...... Do. ...... Citrus paradisi Macf. Guava ...... Psidium spp. Hickory bark ...... Carya spp. Horehound (hoarhound) ...... Marrubium vulgare L. Hops ...... Humulus lupulus L. Horsemint ...... Monarda punctata L. Hyssop ...... Hyssopus officinalis L. Immortelle ...... Helichrysum augustifolium DC. Jasmine ...... Jaminum officinale L. and other spp. of Jasminum. Juniper (berries) ...... Juniperus communis L. Kola nut ...... Cola acuminata Schott and Endl., and other spp. of Cola. Laurel berries ...... Laurus nobilis L. Laurel leaves ...... Laurus spp. Lavender ...... Lavandula officinalis Chaix. Lavender, spike ...... Lavandula latifolia Vill. Lavandin ...... Hybrids between Lavandula officinalis Chaix and Lavandula latifolin Vill. Lemon ...... Citrus limon (L.) Burm. f. Lemon balm (see balm). Lemon grass ...... Cymbopogon citratus DC. and Cymbopogon flexuosus Stapf. Lemon peel ...... Citrus limon (L.) Burm. f. Licorice ...... Glycyrrhiza glabra L. and other spp. of Glycyrrhiza. ...... Citrus aurantifolia Swingle. Linden flowers ...... Tilia spp. Locust bean ...... Ceratonia siliqua L. Lupulin ...... Humulus lupulus L. Mace ...... Myristica fragrans Houtt. Malt (extract) ...... Hordeum vulgare L., or other grains. Mandarin ...... Citrus reticulata Blanco. Marjoram, sweet ...... Majorana hortensis Moench.

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Common name Botanical name of plant source

Mate 1 ...... Ilex paraguariensis St. Hil. Melissa (see balm). Menthol ...... Mentha spp. Menthyl acetate ...... Do. Molasses (extract) ...... Saccharum officinarum L. Mustard ...... Brassica spp. Naringin ...... Citrus paradisi Macf. , bigarade ...... Citrus aurantium L. Nutmeg ...... Myristica fragrans Houtt. Onion ...... Allium cepa L. Orange, bitter, flowers ...... Citrus aurantium L. Orange, bitter, peel ...... Do. Orange leaf ...... Citrus sinensis (L.) Osbeck. Orange, sweet ...... Do. Orange, sweet, flowers ...... Do. Orange, sweet, peel ...... Do. Origanum ...... Origanum spp. Palmarosa ...... Cymbopogon martini Stapf. Paprika ...... Capsicum annuum L. Parsley ...... Petroselinum crispum (Mill.) Mansf. Pepper, black ...... Piper nigrum L. Pepper, white ...... Piper nigrum L. Peppermint ...... Mentha piperita L. Peruvian balsam ...... Myroxylon pereirae Klotzsch. Petitgrain ...... Citrus aurantium L. Petitgrain lemon ...... Citrus limon (L.) Burm. f. Petitgrain mandarin or ...... Citrus reticulata Blanco. Pimenta ...... Pimenta officinalis Lindl. Pimenta leaf ...... Primenta officinalis Lindl. Pipsissewa leaves ...... Chimaphila umbellata Nutt. Pomegranate ...... Punica granatum L. Prickly ash bark ...... Xanthoxylum (or Zanthoxylum) Americanum Mill. or Xanthoxylum clava-herculis L. Rose absolute ...... Rosa alba L., Rosa centifolia L., Rosa damascena Mill., Rosa gallica L., and vars. of these spp. Rose (otto of roses, attar of roses) ...... Do. Rose buds ...... Do. Rose flowers ...... Do. Rose fruit (hips) ...... Do. Rose geranium ...... Pelargonium graveolens L’Her. Rose leaves ...... Rosa spp. Rosemary ...... Rosmarinus officinalis L. Rue ...... Ruta graveolens L. Saffron ...... Crocus sativus L. Sage ...... Salvia officinalis L. Sage, Greek ...... Salvia triloba L. Sage, Spanish ...... Salvia lavandulaefolia Vahl. St. John’s bread ...... Ceratonia siliqua L. Savory, summer ...... Satureia hortensis L. Savory, winter ...... Satureia montana L. Schinus molle ...... Schinus molle L. Sloe berries (blackthorn berries) ...... Prunus spinosa L. Spearmint ...... Mentha spicata L. Spike lavender ...... Lavandula latifolia Vill. Tamarind ...... Tamarindus indica L. Tangerine ...... Citrus reticulata Blanco. Tannic acid ...... Nutgalls of Quercus infectoria Oliver and related spp. of Quercus. Also in many other plants. Tarragon ...... Artemisia dracunculus L. Tea ...... Thea sinensis L. Thyme ...... Thymus vulgaris L. and Thymus zygis var. gracilis Boiss. Thyme, white ...... Do. Thyme, wild or creeping ...... Thymus serpyllum L. Triticum (see dog grass). Tuberose ...... Polianthes tuberosa L. Turmeric ...... Curcuma longa L. Vanilla ...... Vanilla planifolia Andr. or Vanilla tahitensis J. W. Moore. Violet flowers ...... Viola odorata L. Violet leaves ...... Do. Violet leaves absolute ...... Do. Wild cherry bark ...... Prunus serotina Ehrh. Ylang-ylang ...... Cananga odorata Hook. f. and Thoms. Zedoary bark ...... Curcuma zedoaria Rosc.

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§ 582.30 Natural substances used in seasonings and flavorings that are gen- conjunction with spices and other erally recognized as safe for their in- natural seasonings and flavorings. tended use, within the meaning of sec- Natural substances used in conjunc- tion 409 of the act, are as follows: tion with spices and other natural

Common name Botanical name of plant source

Algae, brown (kelp) ...... Laminaria spp. and Nereocystis spp. Algae, red ...... Porphyra spp. and Rhodymenia palmata (L.) Grev. Dulse ...... Rhodymenia palmata (L.)

§ 582.40 Natural extractives (solvent- seasonings, and flavorings that are free) used in conjunction with generally recognized as safe for their spices, seasonings, and flavorings. intended use, within the meaning of Natural extractives (solvent-free) section 409 of the act, are as follows: used in conjunction with spices,

Common name Botanical name of plant source

Algae, brown ...... Laminaria spp. and Nereocystis spp. Algae, red ...... Porphyra spp. and Rhodymenia palmata (L.) Grev. Apricot kernel (persic oil) ...... Prunus armeniaca L. Dulse ...... Rhodymenia palmata (L.) Grev. Kelp (see algae, brown). Peach kernel (persic oil) ...... Prunus persica Sieb. et Zucc. Peanut stearine ...... Arachis hypogaea L. Persic oil (see apricot kernel and peach kernel). Quince seed ...... Cydonia oblonga Miller.

§ 582.50 Certain other spices, tracts that are generally recognized as seasonings, essential oils, safe for their intended use, within the oleoresins, and natural extracts. meaning of section 409 of the act, are Certain other spices, seasonings, es- as follows: sential oils, oleoresins, and natural ex-

Common name Derivation

Ambergris ...... Physeter macrocephalus L. Castoreum ...... Castor fiber L. and C. canadensis Kuhl. Civet (zibeth, zibet, zibetum) ...... Civet cats, Viverra civetta Schreber and Viverra zibetha Schreber. Cognac oil, white and green ...... Ethyl oenanthate, so-called. Musk (Tonquin musk) ...... Musk deer, Moschus moschiferus L.

§ 582.60 Synthetic flavoring substances Cinnamaldehyde (cinnamic aldehyde). and adjuvants. Citral (2,6-dimethyloctadien-2,6-al-8, geranial, neral). Synthetic flavoring substances and Decanal (N-decylaldhehyde, capraldehyde, adjuvants that are generally recog- capric aldehyde, caprinaldehyde, aldehyde nized as safe for their intended use, C-10). within the meaning of section 409 of Diacetyl (2,3-butandeione). Ethyl acetate. the act, are as follows: Ethyl butyrate. Acetaldehyde (ethanal). 3-Methyl-3-phenyl glycidic acid ethyl ester Acetoin (acetyl methylcarbinol). (ethyl-methyl-phenyl-glycidate, so-called Aconitic acid (equisetic acid, citridic acid, strawberry aldehyde, C-16 aldehyde). achilleic acid). Ethyl vanillin. Anethole (parapropenyl anisole). Eugenol. Benzaldehyde (benzoic aldehyde). Geranoil (3,7-dimethyl-2,6 and 3,6-octadien-1- N-Butyric acid (butanoic acid). ol). d- or l-Carvone (carvol). Geranyl acetate (geraniol acetate).

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Glycerol (glyceryl) tributyrate (tributyrin, § 582.99 Adjuvants for pesticide chemi- butyrin). cals. (d-, l-, and dl-). Linalool (linalol, 3,7-dimethyl-1,6-octadien-3- Adjuvants, identified and used in ac- ol). cordance with 40 CFR 180.1001(c) and Linalyl acetate (bergamol). (d), which are added to pesticide use di- 1-Malic acid. lutions by a grower or applicator prior Methyl anthranilate (methyl-2- to application to the raw agricultural aminobenzoate). Piperonal (3,4-methylenedioxy-benzaldehyde, commodity, are exempt from the re- heliotropin). quirement of tolerances under section Vanillin. 409 of the act.

§ 582.80 Trace minerals added to ani- Subpart B—General Purpose Food mal feeds. Additives These substances added to animal feeds as nutritional dietary supple- § 582.1005 Acetic acid. ments are generally recognized as safe (a) Product. Acetic acid. when added at levels consistent with (b) Conditions of use. This substance good feeding practice. 1 is generally recognized as safe when Element Source compounds used in accordance with good manufac- turing or feeding practice. Cobalt ...... Cobalt acetate. Cobalt carbonate. Cobalt chloride. § 582.1009 Adipic acid. Cobalt oxide. (a) Product. Adipic acid. Cobalt sulfate. Copper ...... Copper carbonate. (b) [Reserved] Copper chloride. (c) Limitations, restrictions, or expla- Copper gluconate. Copper hydroxide. nation. This substance is generally rec- Copper orthophosphate. ognized as safe when used as a buffer Copper oxide. and neutralizing agent in accordance Copper pyrophosphate. Copper sulfate. with good manufacturing or feeding Iodine ...... Calcium iodate. practice. Calcium iodobehenate. Cuprous iodide. § 582.1033 Citric acid. 3,5-Diiodosalicylic acid. Ethylenediamine dihydroiodide. (a) Product. Citric acid. Potassium iodate. (b) Conditions of use. This substance Potassium iodide. Sodium iodate. is generally recognized as safe when Sodium iodide. used in accordance with good manufac- Thymol iodide. turing or feeding practice. Iron ...... Iron ammonium citrate. Iron carbonate. Iron chloride. § 582.1057 Hydrochloric acid. Iron gluconate. Iron oxide. (a) Product. Hydrochloric acid. Iron phosphate. (b) [Reserved] Iron pyrophosphate. (c) Limitations, restrictions, or expla- Iron sulfate. Reduced iron. nation. This substance is generally rec- Manganese ...... Manganese acetate. ognized as safe when used as a buffer Manganese carbonate. and neutralizing agent in accordance Manganese citrate (soluble). Manganese chloride. with good manufacturing or feeding Manganese gluconate. practice. Manganese orthophosphate. Manganese phosphate (dibasic). § 582.1061 Lactic acid. Manganese sulfate. Manganous oxide. (a) Product. Lactic acid. Zinc ...... Zinc acetate. Zinc carbonate. (b) Conditions of use. This substance Zinc chloride. is generally recognized as safe when Zinc oxide. used in accordance with good manufac- Zinc sulfate. turing or feeding practice.

§ 582.1069 Malic acid. 1 All substances listed may be in anhydrous or hydrated form. (a) Product. Malic acid.

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(b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice.

§ 582.1073 Phosphoric acid. § 582.1129 Aluminum potassium sul- (a) Product. Phosphoric acid. fate. (b) Conditions of use. This substance (a) Product. Aluminum potassium sul- is generally recognized as safe when fate. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.1077 Potassium acid tartrate. turing or feeding practice. (a) Product. Potassium acid tartrate. (b) Conditions of use. This substance § 582.1131 Aluminum sodium sulfate. is generally recognized as safe when (a) Product. Aluminum sodium sul- used in accordance with good manufac- fate. turing or feeding practice. (b) Conditions of use. This substance § 582.1087 Sodium acid pyrophosphate. is generally recognized as safe when used in accordance with good manufac- (a) Product. Sodium acid turing or feeding practice. pyrophosphate. (b) Conditions of use. This substance § 582.1135 Ammonium bicarbonate. is generally recognized as safe when used in accordance with good manufac- (a) Product. Ammonium bicarbonate. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.1091 Succinic acid. used in accordance with good manufac- (a) Product. Succinic acid. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.1137 Ammonium carbonate. used in accordance with good manufac- (a) Product. Ammonium carbonate. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.1095 Sulfuric acid. used in accordance with good manufac- (a) Product. Sulfuric acid. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.1139 Ammonium hydroxide. used in accordance with good manufac- (a) Product. Ammonium hydroxide. turing or feeding practice. (b) Conditions of use. This substance § 582.1099 Tartaric acid. is generally recognized as safe when used in accordance with good manufac- (a) Product. Tartaric acid. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.1141 Ammonium phosphate. used in accordance with good manufac- turing or feeding practice. (a) Product. Ammonium phosphate (mono- and dibasic). § 582.1125 Aluminum sulfate. (b) Conditions of use. This substance (a) Product. Aluminum sulfate. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.1143 Ammonium sulfate. (a) Product. Ammonium sulfate. § 582.1127 Aluminum ammonium sul- (b) Conditions of use. This substance fate. is generally recognized as safe when (a) Product. Aluminum ammonium used in accordance with good manufac- sulfate. turing or feeding practice.

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§ 582.1155 Bentonite. (b) Conditions of use. This substance (a) Product. Bentonite. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- § 582.1217 Calcium phosphate. turing or feeding practice. (a) Product. Calcium phosphate § 582.1165 Butane. (mono-, di-, and tribasic). (a) Product. Butane. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.1235 Caramel. § 582.1191 Calcium carbonate. (a) Product. Caramel. (a) Product. Calcium carbonate. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.1240 Carbon dioxide. § 582.1193 Calcium chloride. (a) Product. Carbon dioxide. (a) Product. Calcium chloride. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.1275 Dextrans. § 582.1195 Calcium citrate. (a) Product. Dextrans of average mo- (a) Product. Calcium citrate. lecular weight below 100,000. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice.

§ 582.1199 Calcium gluconate. § 582.1320 Glycerin. (a) Product. Calcium gluconate. (a) Product. Glycerin. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice.

§ 582.1205 Calcium hydroxide. § 582.1324 Glyceryl monostearate. (a) Product. Calcium hydroxide. (a) Product. Glyceryl monostearate. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice.

§ 582.1207 Calcium lactate. § 582.1355 Helium. (a) Product. Calcium lactate. (a) Product. Helium. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice.

§ 582.1210 Calcium oxide. § 582.1366 Hydrogen peroxide. (a) Product. Calcium oxide. (a) Product. Hydrogen peroxide.

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(b) [Reserved] used in accordance with good manufac- (c) Limitations, restrictions, or expla- turing or feeding practice. nation. This substance is generally rec- ognized as safe when used as a bleach- § 582.1540 Nitrogen. ing agent in accordance with good (a) Product. Nitrogen. manufacturing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.1400 Lecithin. used in accordance with good manufac- (a) Product. Lecithin. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.1585 Papain. used in accordance with good manufac- (a) Product. Papain. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.1425 Magnesium carbonate. used in accordance with good manufac- (a) Product. Magnesium carbonate. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.1613 Potassium bicarbonate. used in accordance with good manufac- (a) Product. Potassium bicarbonate. turing or feeding practice. (b) Conditions of use. This substance § 582.1428 Magnesium hydroxide. is generally recognized as safe when used in accordance with good manufac- (a) Product. Magnesium hydroxide. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.1619 Potassium carbonate. used in accordance with good manufac- turing or feeding practice. (a) Product. Potassium carbonate. (b) Conditions of use. This substance § 582.1431 Magnesium oxide. is generally recognized as safe when used in accordance with good manufac- (a) Product. Magnesium oxide. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.1625 Potassium citrate. used in accordance with good manufac- turing or feeding practice. (a) Product. Potassium citrate. (b) Conditions of use. This substance § 582.1480 Methylcellulose. is generally recognized as safe when (a) Product. U.S.P. methylcellulose, used in accordance with good manufac- except that the methoxy content shall turing or feeding practice. not be less than 27.5 percent and not § 582.1631 Potassium hydroxide. more than 31.5 percent on a dry-weight basis. (a) Product. Potassium hydroxide. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice.

§ 582.1500 Monoammonium glutamate. § 582.1643 Potassium sulfate. (a) Product. Monoammonium glu- (a) Product. Potassium sulfate. tamate. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.1655 Propane. § 582.1516 Monopotassium glutamate. (a) Product. Propane. (a) Product. Monopotassium glu- (b) Conditions of use. This substance tamate. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice.

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§ 582.1666 Propylene glycol. carboxymethyl groups per (a) Product. Propylene glycol. anhydroglucose unit, and with a min- (b) Conditions of use. This substance imum viscosity of 25 centipoises for 2 is generally recognized as safe (except percent by weight aqueous solution at 25 °C. in cat food) when used in accordance (b) Conditions of use. This substance with good manufacturing or feeding is generally recognized as safe when practice. used in accordance with good manufac- [41 FR 38657, Sept. 10, 1976, as amended at 61 turing or feeding practice. FR 19544, May 2, 1996] § 582.1748 Sodium caseinate. § 582.1685 Rennet. (a) Product. Sodium caseinate. (a) Product. Rennet (rennin). (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.1751 Sodium citrate. § 582.1711 Silica aerogel. (a) Product. Sodium citrate. (a) Product. Silica aerogel as a finely (b) Conditions of use. This substance powdered microcellular silica foam is generally recognized as safe when having a minimum silica content of used in accordance with good manufac- 89.5 percent. turing or feeding practice. (b) [Reserved] (c) Limitations, restrictions, or expla- § 582.1763 Sodium hydroxide. nation. This substance is generally rec- (a) Product. Sodium hydroxide. ognized as safe when used as a compo- (b) Conditions of use. This substance nent of antifoaming agents in accord- is generally recognized as safe when ance with good manufacturing or feed- used in accordance with good manufac- ing practice. turing or feeding practice.

§ 582.1721 Sodium acetate. § 582.1775 Sodium pectinate. (a) Product. Sodium acetate. (a) Product. Sodium pectinate. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice.

§ 582.1736 Sodium bicarbonate. § 582.1778 Sodium phosphate. (a) Product. Sodium bicarbonate. (a) Product. Sodium phosphate (b) Conditions of use. This substance (mono-, di-, and tribasic). is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.1742 Sodium carbonate. (a) Product. Sodium carbonate. § 582.1781 Sodium aluminum phos- (b) Conditions of use. This substance phate. is generally recognized as safe when (a) Product. Sodium aluminum phos- used in accordance with good manufac- phate. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.1745 Sodium used in accordance with good manufac- carboxymethylcellulose. turing or feeding practice. (a) Product. Sodium carboxymethyl- cellulose is the sodium salt of § 582.1792 Sodium sesquicarbonate. carboxymethylcellulose not less than (a) Product. Sodium sesquicarbonate. 99.5 percent on a dry-weight basis, with (b) Conditions of use. This substance maximum substitution of 0.95 is generally recognized as safe when

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used in accordance with good manufac- in accordance with good manufacturing turing or feeding practice. or feeding practice.

§ 582.1804 Sodium potassium tartrate. § 582.2227 Calcium silicate. (a) Product. Sodium potassium tar- (a) Product. Calcium silicate. trate. (b) Tolerance. 2 percent and 5 percent. (b) Conditions of use. This substance (c) Limitations, restrictions, or expla- is generally recognized as safe when nation. This substance is generally rec- used in accordance with good manufac- ognized as safe when used at levels not turing or feeding practice. exceeding 2 percent in table salt and 5 percent in baking powder in accordance § 582.1810 Sodium tripolyphosphate. with good manufacturing or feeding (a) Product. Sodium practice. tripolyphosphate. (b) Conditions of use. This substance § 582.2437 Magnesium silicate. is generally recognized as safe when (a) Product. Magnesium silicate. used in accordance with good manufac- (b) Tolerance. 2 percent. turing or feeding practice. (c) Limitations, restrictions, or expla- § 582.1901 Triacetin. nation. This substance is generally rec- ognized as safe when used in table salt (a) Product. Triacetin (glyceryl in accordance with good manufacturing triacetate). or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.2727 Sodium aluminosilicate. used in accordance with good manufac- turing or feeding practice. (a) Product. Sodium aluminosilicate (sodium silicoaluminate). § 582.1973 Beeswax. (b) Tolerance. This substance is gen- erally recognized as safe for use at a (a) Product. Beeswax (yellow wax). level not exceeding 2 percent in accord- (b) Conditions of use. This substance ance with good manufacturing or feed- is generally recognized as safe when ing practice. used in accordance with good manufac- turing or feeding practice. § 582.2729 Hydrated sodium calcium aluminosilicate. § 582.1975 Bleached beeswax. (a) Product. Hydrated sodium calcium (a) Product. Bleached beeswax (white aluminosilicate (sodium calcium wax). silicoaluminate). (b) Conditions of use. This substance is generally recognized as safe when (b) Tolerance. This substance is gen- used in accordance with good manufac- erally recognized as safe for use at a turing or feeding practice. level not exceeding 2 percent in accord- ance with good manufacturing or feed- § 582.1978 Carnauba wax. ing practice. (a) Product. Carnauba wax. § 582.2906 Tricalcium silicate. (b) Conditions of use. This substance is generally recognized as safe when (a) Product. Tricalcium silicate. used in accordance with good manufac- (b) Tolerance. 2 percent. turing or feeding practice. (c) Limitations, restrictions, or expla- nation. This substance is generally rec- Subpart C—Anticaking Agents ognized as safe when used in table salt in accordance with good manufacturing § 582.2122 Aluminum calcium silicate. or feeding practice. (a) Product. Aluminum calcium sili- cate. Subpart D—Chemical (b) Tolerance. 2 percent. Preservatives (c) Limitations, restrictions, or expla- nation. This substance is generally rec- § 582.3013 Ascorbic acid. ognized as safe when used in table salt (a) Product. Ascorbic acid.

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(b) Conditions of use. This substance is not over 0.02 percent of fat or oil is generally recognized as safe when content, including essential (volatile) used in accordance with good manufac- oil content of food provided the sub- turing or feeding practice. stance is used in accordance with good manufacturing or feeding practice. § 582.3021 Benzoic acid. (a) Product. Benzoic acid. § 582.3173 Butylated hydroxytoluene. (b) Tolerance. This substance is gen- (a) Product. Butylated hydroxytol- erally recognized as safe for use at a uene. level not exceeding 0.1 percent in ac- (b) Tolerance. This substance is gen- cordance with good manufacturing or erally recognized as safe for use in food feeding practice. when the total content of antioxidants is not over 0.02 percent of fat or oil § 582.3041 Erythorbic acid. content, including essential (volatile) (a) Product. Erythorbic acid. oil content of food provided the sub- (b) Conditions of use. This substance stance is used in accordance with good is generally recognized as safe when manufacturing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.3189 Calcium ascorbate. (a) Product. Calcium ascorbate. § 582.3081 Propionic acid. (b) Conditions of use. This substance (a) Product. Propionic acid. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.3221 Calcium propionate. (a) Product. Calcium propionate. § 582.3089 Sorbic acid. (b) Conditions of use. This substance (a) Product. Sorbic acid. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.3225 Calcium sorbate. (a) Product. Calcium sorbate. § 582.3109 Thiodipropionic acid. (b) Conditions of use. This substance (a) Product. Thiodipropionic acid. is generally recognized as safe when (b) Tolerance. This substance is gen- used in accordance with good manufac- erally recognized as safe for use in food turing or feeding practice. when the total content of antioxidants is not over 0.02 percent of fat or oil § 582.3280 Dilauryl thiodipropionate. content including essential (volatile) (a) Product. Dilauryl oil content of the food, provided the thiodipropionate. substance is used in accordance with (b) Tolerance. This substance is gen- good manufacturing or feeding prac- erally recognized as safe for use in food tice. when the total content of antioxidants is not over 0.02 percent of fat or oil § 582.3149 Ascorbyl palmitate. content, including essential (volatile) (a) Product. Ascorbyl palmitate. oil content of the food, provided the (b) Conditions of use. This substance substance is used in accordance with is generally recognized as safe when good manufacturing or feeding prac- used in accordance with good manufac- tice. turing or feeding practice. § 582.3336 Gum guaiac. § 582.3169 Butylated hydroxyanisole. (a) Product. Gum guaiac. (a) Product. Butylated hydroxy- (b) Tolerance. 0.1 percent (equivalent anisole. antioxidant activity 0.01 percent). (b) Tolerance. This substance is gen- (c) Limitations, restrictions, or expla- erally recognized as safe for use in food nation. This substance is generally rec- when the total content of antioxidants ognized as safe when used in edible fats

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or oils in accordance with good manu- cordance with good manufacturing or facturing or feeding practice. feeding practice.

§ 582.3490 Methylparaben. § 582.3731 Sodium ascorbate. (a) Product. Methylparaben (methyl (a) Product. Sodium ascorbate. p-hydroxybenzoate). (b) Conditions of use. This substance (b) Tolerance. This substance is gen- is generally recognized as safe when erally recognized as safe for use at a used in accordance with good manufac- level not exceeding 0.1 percent in ac- turing or feeding practice. cordance with good manufacturing or feeding practice. § 582.3733 Sodium benzoate. § 582.3616 Potassium bisulfite. (a) Product. Sodium benzoate. (b) Tolerance. This substance is gen- (a) Product. Potassium bisulfite. erally recognized as safe for use at a (b) [Reserved] level not exceeding 0.1 percent in ac- (c) Limitations, restrictions, or expla- nation. This substance is generally rec- cordance with good manufacturing or ognized as safe when used in accord- feeding practice. ance with good manufacturing or feed- § 582.3739 Sodium bisulfite. ing practice, except that it is not used in meats or in food recognized as (a) Product. Sodium bisulfite. source of vitamin B1. (b) [Reserved] (c) Limitations, restrictions, or expla- § 582.3637 Potassium metabisulfite. nation. This substance is generally rec- (a) Product. Potassium metabisulfite. ognized as safe when used in accord- (b) [Reserved] ance with good manufacturing or feed- (c) Limitations, restrictions, or expla- ing practice, except that it is not used nation. This substance is generally rec- in meats or in food recognized as ognized as safe when used in accord- source of vitamin B1. ance with good manufacturing or feed- ing practice, except that it is not used § 582.3766 Sodium metabisulfite. in meats or in food recognized as (a) Product. Sodium metabisulfite. source of vitamin B1. (b) [Reserved] (c) Limitations, restrictions, or expla- § 582.3640 Potassium sorbate. nation. This substance is generally rec- (a) Product. Potassium sorbate. ognized as safe when used in accord- (b) Conditions of use. This substance ance with good manufacturing or feed- is generally recognized as safe when ing practice, except that it is not used used in accordance with good manufac- in meats or in food recognized as turing or feeding practice. source of vitamin B1.

§ 582.3660 Propyl gallate. § 582.3784 Sodium propionate. (a) Product. Propyl gallate. (a) Product. Sodium propionate. (b) Tolerance. This substance is gen- (b) Conditions of use. This substance erally recognized as safe for use in food is generally recognized as safe when when the total content of antioxidants used in accordance with good manufac- is not over 0.02 percent of fat or oil turing or feeding practice. content, including essential (volatile) oil content of the food, provided the § 582.3795 Sodium sorbate. substance is used in accordance with good manufacturing or feeding prac- (a) Product. Sodium sorbate. tice. (b) Conditions of use. This substance is generally recognized as safe when § 582.3670 Propylparaben. used in accordance with good manufac- (a) Product. Propylparaben (propyl p- turing or feeding practice. hydroxybenzoate). (b) Tolerance. This substance is gen- § 582.3798 Sodium sulfite. erally recognized as safe for use at a (a) Product. Sodium sulfite. level not exceeding 0.1 percent in ac- (b) [Reserved]

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(c) Limitations, restrictions, or expla- § 582.4521 Monosodium phosphate de- nation. This substance is generally rec- rivatives of mono- and diglycerides ognized as safe when used in accord- of edible fats or oils, or edible fat- ance with good manufacturing or feed- forming fatty acids. ing practice, except that it is not used (a) Product. Monosodium phosphate in meats or in food recognized as derivatives of mono- and diglycerides source of vitamin B1. of edible fats or oils, or edible fat-form- ing fatty acids. § 582.3845 Stannous chloride. (b) Conditions of use. This substance (a) Product. Stannous chloride. is generally recognized as safe when (b) Tolerance. This substance is gen- used in accordance with good manufac- erally recognized as safe for use at a turing or feeding practice. level not exceeding 0.0015 percent cal- culated as tin in accordance with good § 582.4666 Propylene glycol. manufacturing or feeding practice. (a) Product. Propylene glycol. (b) Conditions of use. This substance § 582.3862 Sulfur dioxide. is generally recognized as safe when (a) Product. Sulfur dioxide. used in accordance with good manufac- (b) [Reserved] turing or feeding practice. (c) Limitations, restrictions, or expla- nation. This substance is generally rec- Subpart F—Nutrients and/or ognized as safe when used in accord- Dietary Supplements 1 ance with good manufacturing or feed- ing practice, except that it is not used § 582.5013 Ascorbic acid. in meats or in food recognized as source of vitamin B . (a) Product. Ascorbic acid. 1 (b) Conditions of use. This substance § 582.3890 Tocopherols. is generally recognized as safe when used in accordance with good manufac- (a) Product. Tocopherols. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.5017 Aspartic acid. used in accordance with good manufac- turing or feeding practice. (a) Product. Aspartic acid (L- and DL- forms). (b) Conditions of use. This substance Subpart E—Emulsifying Agents is generally recognized as safe when § 582.4101 Diacetyl tartaric acid esters used in accordance with good manufac- of mono- and diglycerides of edible turing or feeding practice. fats or oils, or edible fat-forming fatty acids. § 582.5049 Aminoacetic acid. (a) Product. Diacetyl tartaric acid (a) Product. Glycine (aminoacetic esters of mono- and diglycerides of edi- acid). ble fats or oils, or edible fat-forming (b) [Reserved] fatty acids. (c) Limitations, restrictions, or expla- (b) Conditions of use. This substance nation. This substance is generally rec- is generally recognized as safe when ognized as safe when used in animal used in accordance with good manufac- feeds in accordance with good manu- turing or feeding practice. facturing or feeding practice.

§ 582.4505 Mono- and diglycerides of § 582.5065 Linoleic acid. edible fats or oils, or edible fat- (a) Product. Linoleic acid prepared forming acids. from edible fats and oils and free from (a) Product. Mono- and diglycerides of chick-edema factor. edible fats or oils, or edible fat-forming (b) Conditions of use. This substance acids. is generally recognized as safe when (b) Conditions of use. This substance is generally recognized as safe when 1 Amino acids listed in this subpart may be used in accordance with good manufac- free hydrochloride salt, hydrated, or anhy- turing or feeding practice. drous form, where applicable.

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used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.5118 Alanine. turing or feeding practice. (a) Product. Alanine (L- and DL- forms). § 582.5217 Calcium phosphate. (b) Conditions of use. This substance (a) Product. Calcium phosphate is generally recognized as safe when (mono-, di-, and tribasic). used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.5145 Arginine. turing or feeding practice. (a) Product. Arginine (L- and DL- § 582.5223 Calcium pyrophosphate. forms). (b) Conditions of use. This substance (a) Product. Calcium pyrophosphate. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.5159 Biotin. § 582.5230 Calcium sulfate. (a) Product. Biotin. (b) Conditions of use. This substance (a) Product. Calcium sulfate. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.5191 Calcium carbonate. § 582.5245 Carotene. (a) Product. Calcium carbonate. (a) Product. Carotene. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice.

§ 582.5195 Calcium citrate. § 582.5250 Choline bitartrate. (a) Product. Calcium citrate. (a) Product. Choline bitartrate. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice.

§ 582.5201 Calcium glycerophosphate. § 582.5252 Choline chloride. (a) Product. Calcium (a) Product. Choline chloride. glycerophosphate. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.5260 Copper gluconate. § 582.5210 Calcium oxide. (a) Product. Copper gluconate. (a) Product. Calcium oxide. (b) Tolerance. This substance is gen- (b) Conditions of use. This substance erally recognized as safe for use at a is generally recognized as safe when level not exceeding 0.005 percent in ac- used in accordance with good manufac- cordance with good manufacturing or turing or feeding practice. feeding practice.

§ 582.5212 Calcium pantothenate. § 582.5271 Cysteine. (a) Product. Calcium pantothenate. (a) Product. Cysteine (L-forms).

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(b) Conditions of use. This substance § 582.5361 Histidine. is generally recognized as safe when (a) Product. Histidine (L- and DL- used in accordance with good manufac- forms). turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.5273 Cystine. used in accordance with good manufac- (a) Product. Cystine (L- and DL- turing or feeding practice. forms). (b) Conditions of use. This substance § 582.5370 Inositol. is generally recognized as safe when (a) Product. Inositol. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.5301 Ferric phosphate. turing or feeding practice. (a) Product. Ferric phosphate. § 582.5375 Iron reduced. (b) Conditions of use. This substance is generally recognized as safe when (a) Product. Iron reduced. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.5304 Ferric pyrophosphate. turing or feeding practice. (a) Product. Ferric pyrophosphate. § 582.5381 Isoleucine. (b) Conditions of use. This substance (a) Product. Isoleucine (L- and DL- is generally recognized as safe when forms). used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.5306 Ferric sodium turing or feeding practice. pyrophosphate. (a) Product. Ferric sodium § 582.5406 Leucine. pyrophosphate. (a) Product. Leucine (L- and DL- (b) Conditions of use. This substance forms). is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.5308 Ferrous gluconate. § 582.5411 Lysine. (a) Product. Ferrous gluconate. (b) Conditions of use. This substance (a) Product. Lysine (L- and DL- is generally recognized as safe when forms). used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.5311 Ferrous lactate. turing or feeding practice. (a) Product. Ferrous lactate. § 582.5431 Magnesium oxide. (b) Conditions of use. This substance (a) Product. Magnesium oxide. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.5315 Ferrous sulfate. (a) Product. Ferrous sulfate. § 582.5434 Magnesium phosphate. (b) Conditions of use. This substance (a) Product. Magnesium phosphate is generally recognized as safe when (di- and tribasic). used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when

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used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice.

§ 582.5443 Magnesium sulfate. § 582.5470 Mannitol. (a) Product. Magnesium sulfate. (a) Product. Mannitol. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice.

§ 582.5446 Manganese chloride. § 582.5475 Methionine. (a) Product. Manganese chloride. (a) Product. Methionine. (b) Conditions of use. This substance (b) [Reserved] is generally recognized as safe when (c) Limitations, restrictions, or expla- used in accordance with good manufac- nation. This substance is generally rec- turing or feeding practice. ognized as safe when used in animal § 582.5449 Manganese citrate. feeds in accordance with good manu- facturing or feeding practice. (a) Product. Manganese citrate. (b) Conditions of use. This substance § 582.5477 Methionine hydroxy analog is generally recognized as safe when and its calcium salts. used in accordance with good manufac- (a) Product. Methionine hydroxy ana- turing or feeding practice. log and its calcium salts. § 582.5452 Manganese gluconate. (b) [Reserved] (c) Limitations, restrictions, or expla- (a) Product. Manganese gluconate. nation. This substance is generally rec- (b) Conditions of use. This substance ognized as safe when used in animal is generally recognized as safe when feeds in accordance with good manu- used in accordance with good manufac- facturing or feeding practice. turing or feeding practice. § 582.5530 Niacin. § 582.5455 Manganese glycerophosphate. (a) Product. Niacin. (a) Product. Manganese (b) Conditions of use. This substance glycerophosphate. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- § 582.5535 Niacinamide. turing or feeding practice. (a) Product. Niacinamide. § 582.5458 Manganese hypophosphite. (b) Conditions of use. This substance (a) Product. Manganese is generally recognized as safe when hypophosphite. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.5580 D-Pantothenyl alcohol. turing or feeding practice. (a) Product. D-Pantothenyl alcohol. (b) Conditions of use. This substance § 582.5461 Manganese sulfate. is generally recognized as safe when (a) Product. Manganese sulfate. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.5590 Phenylalanine. turing or feeding practice. (a) Product. Phenylalanine (L- and DL-forms). § 582.5464 Manganous oxide. (b) Conditions of use. This substance (a) Product. Manganous oxide. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice.

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§ 582.5622 Potassium chloride. (b) Conditions of use. This substance (a) Product. Potassium chloride. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- § 582.5772 Sodium pantothenate. turing or feeding practice. (a) Product. Sodium pantothenate. § 582.5628 Potassium (b) Conditions of use. This substance glycerophosphate. is generally recognized as safe when (a) Product. Potassium used in accordance with good manufac- glycerophosphate. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.5778 Sodium phosphate. used in accordance with good manufac- (a) Product. Sodium phosphate turing or feeding practice. (mono-, di-, and tribasic). (b) Conditions of use. This substance § 582.5634 Potassium iodide. is generally recognized as safe when (a) Product. Potassium iodide. used in accordance with good manufac- (b) Tolerance. 0.01 percent. turing or feeding practice. (c) Limitations, restrictions, or expla- nation. This substance is generally rec- § 582.5835 Sorbitol. ognized as safe when used in table salt (a) Product. Sorbitol. as a source of dietary iodine in accord- (b) Conditions of use. This substance ance with good manufacturing or feed- is generally recognized as safe when ing practice. used in accordance with good manufac- turing or feeding practice. § 582.5650 Proline. (a) Product. Proline (L- and DL- § 582.5875 Thiamine hydrochloride. forms). (a) Product. Thiamine hydrochloride. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice.

§ 582.5676 Pyridoxine hydrochloride. § 582.5878 Thiamine mononitrate. (a) Product. Pyridoxine hydro- (a) Product. Thiamine mononitrate. chloride. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.5881 Threonine. § 582.5695 Riboflavin. (a) Product. Threonine (L- and DL- (a) Product. Riboflavin. forms). (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice.

§ 582.5697 Riboflavin-5-phosphate. § 582.5890 Tocopherols. (a) Product. Riboflavin-5-phosphate. (a) Product. Tocopherols. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice.

§ 582.5701 Serine. § 582.5892 a-Tocopherol acetate. (a) Product. Serine (L- and DL-forms). (a) Product. a-Tocopherol acetate.

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(b) Conditions of use. This substance § 582.5950 Vitamin D2. is generally recognized as safe when (a) Product. Vitamin D2. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.5915 Tryptophane. turing or feeding practice. (a) Product. Tryptophane (L- and DL- forms). § 582.5953 Vitamin D3.

(b) Conditions of use. This substance (a) Product. Vitamin D3. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.5920 Tyrosine. § 582.5985 Zinc chloride. (a) Product. Tyrosine (L- and DL- forms). (a) Product. Zinc chloride. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.5988 Zinc gluconate. § 582.5925 Valine. (a) Product. Zinc gluconate. (a) Product. Valine (L- and DL- (b) Conditions of use. This substance forms). is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.5991 Zinc oxide. (a) Product. Zinc oxide. § 582.5930 Vitamin A. (b) Conditions of use. This substance (a) Product. Vitamin A. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.5994 Zinc stearate. (a) Product. Zinc stearate prepared § 582.5933 Vitamin A acetate. from stearic acid free from chick- (a) Product. Vitamin A acetate. edema factor. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.5997 Zinc sulfate. § 582.5936 Vitamin A palmitate. (a) Product. Zinc sulfate. (a) Product. Vitamin A palmitate. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. Subpart G—Sequestrants 2 § 582.5945 Vitamin B12.

(a) Product. Vitamin B12. § 582.6033 Citric acid. (b) Conditions of use. This substance (a) Product. Citric acid. is generally recognized as safe when used in accordance with good manufac- 2 For the purpose of this subpart, no at- turing or feeding practice. tempt has been made to designate those

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(b) Conditions of use. This substance § 582.6203 Calcium is generally recognized as safe when hexametaphosphate. used in accordance with good manufac- (a) Product. Calcium turing or feeding practice. hexametaphosphate. (b) Conditions of use. This substance § 582.6085 Sodium acid phosphate. is generally recognized as safe when (a) Product. Sodium acid phosphate. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.6215 Monobasic calcium phos- turing or feeding practice. phate. (a) Product. Monobasic calcium phos- § 582.6099 Tartaric acid. phate. (a) Product. Tartaric acid. (b) Conditions of use. This substance is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.6219 Calcium phytate. § 582.6185 Calcium acetate. (a) Product. Calcium phytate. (b) Conditions of use. This substance (a) Product. Calcium acetate. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.6285 Dipotassium phosphate. (a) Product. Dipotassium phosphate. § 582.6193 Calcium chloride. (b) Conditions of use. This substance (a) Product. Calcium chloride. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.6290 Disodium phosphate. (a) Product. Disodium phosphate. § 582.6195 Calcium citrate. (b) Conditions of use. This substance (a) Product. Calcium citrate. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- § 582.6386 Isopropyl citrate. turing or feeding practice. (a) Product. Isopropyl citrate. § 582.6197 Calcium diacetate. (b) Tolerance. This substance is gen- erally recognized as safe for use at a (a) Product. Calcium diacetate. level not exceeding 0.02 percent in ac- (b) Conditions of use. This substance cordance with good manufacturing or is generally recognized as safe when feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.6511 Monoisopropyl citrate. § 582.6199 Calcium gluconate. (a) Product. Monoisopropyl citrate. (b) Conditions of use. This substance (a) Product. Calcium gluconate. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.6625 Potassium citrate. (a) Product. Potassium citrate. sequestrants that may also function as (b) Conditions of use. This substance chemical preservatives. is generally recognized as safe when

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used in accordance with good manufac- § 582.6789 Tetra sodium turing or feeding practice. pyrophosphate. [41 FR 38657, Sept. 10, 1976. Redesignated at (a) Product. Tetra sodium 42 FR 14091, Mar. 15, 1977] pyrophosphate. (b) Conditions of use. This substance § 582.6751 Sodium citrate. is generally recognized as safe when (a) Product. Sodium citrate. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.6801 Sodium tartrate. turing or feeding practice. (a) Product. Sodium tartrate. [41 FR 38657, Sept. 10, 1976. Redesignated at (b) Conditions of use. This substance 42 FR 14091, Mar. 15, 1977] is generally recognized as safe when used in accordance with good manufac- § 582.6754 Sodium diacetate. turing or feeding practice. (a) Product. Sodium diacetate. (b) Conditions of use. This substance § 582.6804 Sodium potassium tartrate. is generally recognized as safe when (a) Product. Sodium potassium tar- used in accordance with good manufac- trate. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.6757 Sodium gluconate. used in accordance with good manufac- (a) Product. Sodium gluconate. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.6807 Sodium thiosulfate. used in accordance with good manufac- (a) Product. Sodium thiosulfate. turing or feeding practice. (b) Tolerance. 0.1 percent. (c) Limitations, restrictions, or expla- § 582.6760 Sodium hexametaphosphate. nation. This substance is generally rec- ognized as safe when used in salt in ac- (a) Product. Sodium cordance with good manufacturing or hexametaphosphate. feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.6810 Sodium tripolyphosphate. used in accordance with good manufac- (a) Product. Sodium turing or feeding practice. tripolyphosphate. § 582.6769 Sodium metaphosphate. (b) Conditions of use. This substance is generally recognized as safe when (a) Product. Sodium metaphosphate. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.6851 Stearyl citrate. turing or feeding practice. (a) Product. Stearyl citrate. § 582.6778 Sodium phosphate. (b) Tolerance. This substance is gen- (a) Product. Sodium phosphate erally recognized as safe for use at a (mono-, di-, and tribasic). level not exceeding 0.15 percent in ac- (b) Conditions of use. This substance cordance with good manufacturing or is generally recognized as safe when feeding practice. used in accordance with good manufac- turing or feeding practice. Subpart H—Stabilizers

§ 582.6787 Sodium pyrophosphate. § 582.7115 Agar-agar. (a) Product. Sodium pyrophosphate. (a) Product. Agar-agar. (b) Condition of use. This substance is (b) Conditions of use. This substance generally recognized as safe when used is generally recognized as safe when in accordance with good manufacturing used in accordance with good manufac- or feeding practice. turing or feeding practice.

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§ 582.7133 Ammonium alginate. § 582.7351 Gum tragacanth. (a) Product. Ammonium alginate. (a) Product. Tragacanth (gum (b) Conditions of use. This substance tragacanth). is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.7187 Calcium alginate. (a) Product. Calcium alginate. § 582.7610 Potassium alginate. (b) Conditions of use. This substance (a) Product. Potassium alginate. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.7255 Chondrus extract. (a) Product. Chondrus extract § 582.7724 Sodium alginate. (carrageenin). (a) Product. Sodium alginate. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.7330 Gum arabic. PART 584—FOOD SUBSTANCES AF- (a) Product. Acacia (gum arabic). (b) Conditions of use. This substance FIRMED AS GENERALLY RECOG- is generally recognized as safe when NIZED AS SAFE IN FEED AND used in accordance with good manufac- DRINKING WATER OF ANIMALS turing or feeding practice. Subpart A [Reserved] § 582.7333 Gum ghatti. Subpart B—Listing of Specific Substances (a) Product. Gum ghatti. Affirmed as GRAS (b) Conditions of use. This substance is generally recognized as safe when Sec. used in accordance with good manufac- 584.200 Ethyl alcohol containing ethyl ace- turing or feeding practice. tate. 584.700 Hydrophobic silicas. § 582.7339 Guar gum. AUTHORITY: 21 U.S.C. 321, 342, 348, 371. (a) Product. Guar gum. (b) Conditions of use. This substance Subpart A [Reserved] is generally recognized as safe when used in accordance with good manufac- turing or feeding practice. Subpart B—Listing of Specific Substances Affirmed as GRAS § 582.7343 Locust bean gum. § 584.200 Ethyl alcohol containing (a) Product. Locust (carob) bean gum. ethyl acetate. (b) Conditions of use. This substance is generally recognized as safe when The feed additive ethyl alcohol con- used in accordance with good manufac- taining ethyl acetate meets the re- turing or feeding practice. quirement of 27 CFR 212.45, being not less than 92.5 percent ethyl alcohol, § 582.7349 Sterculia gum. each 100 gallons having had added the equivalent of 4.25 gallons of 100 percent (a) Product. Sterculia gum (karaya ethyl acetate. It is used in accordance gum). with good feeding practices in rumi- (b) Conditions of use. This substance nant feed supplements as a source of is generally recognized as safe when added energy. used in accordance with good manufac- turing or feeding practice. [46 FR 52333, Oct. 27, 1981]

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