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Uclamedicine SUMMEr 2011 uclaMEDICINE ASurgSeonescatoUnCLdA peHrforamnfirdst h,aand Straenscploannt indthCe Whestaernn Uc.Se. Foreign Exchange Partnership with Chinese university opens the door to broader global reach A New Paradigm UCLA puts patients front and center Sisterhood Female philanthropists support research in women’s health Conversation Dr. Mario C. Deng takes heart Spring11_Cover.FINAL.indd 1 6/9/11 12:36 PM UCla mEdiCiNE inside This issue sPRinG 2011 • voluMe 31 nuMbeR 1 01 • Leadership A PublicATion oF The From the dean: Recommitting ourselves to basic research. DAviD GeFFen school oF MeDicine AT uclA by a. eugene washington, m.d., m.sc. ChAnCELLor Gene D. block 02 • The Cutting Edge News and research: The pain of loneliness. ViCE ChAnCELLor, UCLA hEALTh SCiEnCES DEAn, DAViD GEFFEn SChooL • oF MEDiCinE AT UCLA 08 Conversation GErALD S. LEVEy, M.D., EnDoWED ChAir Dr. Mario C. Deng, medical director of the Advanced A. euGene WAshinGTon, M.D., M.sc. Heart Failure, Mechanical Circulatory Support and Heart Transplant Program. DirECTor, MArkETinG PATTie cuen FEatUrEs MAnAGEr, MArkETinG CoMMUniCATionS JuDi GooDFRienD 12 • A Second hand, a Second Chance The first hand transplant in the Western U.S. offers EDiTor a young mother renewed hope. by david greenwald DAviD GReenWAlD DESiGn DirECTor 18 • Foreign Exchange susAn lAnDesMAnn UCLA’s partnership with a medical school in China opens the door to broader global reach. by justin bergman ConTribUTinG WriTErS JusTin beRGMAn • MonA GAble 22 A new Paradigm DAn GoRDon UCLA moves toward a more integrated approach to o r kiM koWsky providing care. by dan gordon u k u MARk s. liTWin, M.D., M.P.h. b a m JosePh A. Michelli, Ph.D. i • h 26 The Excellence rx s Ginny kinG suPPle e u How UCLA Health System elevated the patient experience. z vAleRie WAlkeR o k . by joseph a. michelli, ph.d. r d f o y s e Editorial advisory CommittEE 28 • Sisterhood t r u An innovative program draws female philanthropists o AlAn G. Robinson, M.D. c ) y J. ThoMAs RosenThAl, M.D. t to support research in women’s health. by mona gable l u co-chairs c a f ( ; JAMes W. DAvis, JR., M.D. n NEWs + NotEs e l l bRuce h. Dobkin, M.D. o b s PATRick T. DoWlinG, M.D. e 34 • Faculty notes m a j DieTeR R. enzMAnn, M.D. ) Notables, honors and achievements: Going home to help. e g n Joy s. FRAnk, Ph.D. a h c x JuDiTh c. GAsson, Ph.D. 36 • Alumni notes e n g GARy GiTnick, M.D. i e What’s happening from the MAA: Design for Sharing. r o f e. cARMAck holMes, M.D. ( : y h bARTly J. MonDino, M.D. • p 38 Friends a r neil h. PARkeR, M.D. g o Donor roundup: A chair to offer comfort. t o MichAel e. PhelPs, Ph.D. h p . l JAneT P. PReGleR, M.D. l 41 • Epilogue e w d leonARD h. RoMe, Ph.D. l A life passes, a ritual of birth begins. a c ARnolD b. scheibel, M.D. k r by mark s. litwin, m.d., m.p.h. i k ) PeTeR c. WhybRoW, M.D. e g d Cover: A study of a woman’s hands, c.1490. Leonardo da e g n i t © copyright 2011 by The Regents of the university of Vinci. The Royal Collection © 2011, Her Majesty Queen t u c california. Permission to reprint may be granted by ( Elizabeth II. : n contacting the editor, uclA Medicine, 10920 Wilshire o i t blvd., suite 1850, los Angeles, cA 90024. a r email: [email protected] t s u l l Dear reader: Share your thoughts with us. Submit i Printed on recycled paper. letters to: [email protected]. Spring11_TOC_FINAL.indd 2 6/9/11 12:37 PM leadership OUR CORE COMMITMENT. Basic research is at the heart of everything we do, from work at the bench to educating future healthcare leaders to transforming patient care to promoting healthy communities. magine living in a world where there is no need A group of researchers at the School of Medicine for organ transplants – because failing kidneys and has succeeded in using genetically modified human faltering hearts can be induced, through stem-cell stem cells to target melanoma, the least common but therapy, to heal themselves. The dedicated women and most deadly form of skin cancer. This cancer kills one men who conduct research at the David Geffen School American every hour, and the incidence of melanoma is of Medicine at UCLA and UCLA Health System rising faster than the rates for the seven most common have imagined such a world, and the work they are cancers – up 60 percent in the last 30 years. engaged in today is laying the solid scientific founda- The stem cells used in this experiment were tion for a future in which such miraculous self-repair genetically altered to recognize and kill melanoma is commonplace. cells in mice with human immune systems. Treatment Little more than half-a-century ago, routine trans- with these specialized cells led to a dramatic decrease plantation of organs seemed equally farfetched, but in the size of melanoma tumors in the mice. Obviously, that did not deter a group of researchers at UCLA this new approach to targeting solid-tumor cancers is Ifrom envisioning such a world – and preparing for it by still in its infancy, but we can imagine a world in which developing a method of tissue-matching that reduces many cancers will be treated in this way – with pinpoint the likelihood a donated organ will be rejected. Some effectiveness and without the onerous side effects of 4,300 successful transplants of organs taken from 2,190 standard chemotherapy. donors were performed in this country in the first two In pursuing our vision to “discover the basis for months of this year alone. All of those recipients were health and cures for disease,” we are recommitting indirect beneficiaries of basic research conducted at ourselves to basic research, building an efficient UCLA in the 1960s. infrastructure to facilitate that research, optimizing At a time when we are celebrating the expansion of the use of laboratory space, and recruiting outstanding translational science at UCLA, and nationally, these faculty members. Today’s medical reality is being aus- heartening statistics remind us of the value and vitality piciously altered through the efforts of our biomedical of the fundamental research being conducted in our scientists – men and women who keep UCLA in the laboratories. This research undergirds and guides every- vanguard of the basic science that will yield tomorrow’s thing we do here at UCLA. It not only feeds our trans- medical reality. lational pipeline, it also underpins our efforts to educate leaders in the health sciences, to transform patient care, and to promote healthy communities. Fortunately, we are building for the future on the bedrock of a rich history of biomedical discovery, aided by a faculty of basic scientists who are collectively com- i n a i mitted to the School of Medicine’s new strategic plan d e i n to “discover the basis for health and cures for disease.” h a p e I could cite a dozen examples of basic research being t s A. euGene WAshinGTon, M.D., M.sc. : y conducted at UCLA that foster this plan, but I think h p a that one will suffice, both because of its novelty and r Vice Chancellor, UCLA Health Sciences g o t because of its potential application to a wide range of Dean, David Geffen School of Medicine at UCLA o h p human cancers. Gerald S. Levey, M.D., Endowed Chair UCLA MediCine 1 FALL10_Leadership_v3.indd 1 6/9/11 12:37 PM the cutting edge news and research report immune cells and found that genes originating from two particular cell types – plasmacytoid dendritic cells and monocytes – were over- expressed in chroni- cally lonely individuals, compared with the re- mainder of the sample. These cell types produce an inflammatory re- sponse to tissue dam- age and are part of the immune system’s first line of defense, which produces an immediate inflammatory response The Pain of Loneliness to tissue damage. It’s this same inflammatory response that, over the loneliness is no fun, and now it appears it’s long-term, can promote cardiovascular disease, cancer bad for you as well. UCLA researchers report that and neurodegeneration. Chronically lonely chronically lonely people may be at higher risk for The report provides further evidence of how lifestyle people may be at higher certain types of inflammatory disease, because their and social environments can effect human health. In feelings of social isolation trigger the activity of addition, the researchers suggest that evolutionarily risk for certain types of pro-inflammatory immune cells. ancient immune-system cells may have developed a inflammatory disease. In their analysis of 93 older adults, the researchers molecular sensitivity to our social environment in order screened for gene function among different types of to help defend us against socially transmitted pathogens. Extreme Morning Sickness? it Could be your Genes approximaTely 60,000 And for women and the University of more than 17-fold risk of pregnanT women are with sisters, mothers Southern California. experiencing the debili- hospiTalized each year and grandmothers Researchers traced tating condition, too. due to hyperemesis gravi- who have experienced the family histories of “Pregnant women darum (HG), an extreme extreme morning sick- women with HG and with a family history form of nausea and vom- ness during pregnancy, found not only that of extreme nausea in iting that endangers their the risk of HG may be the condition could be pregnancy should be lives and often forces heightened, according genetic, but also that aware that they may have them to reluctantly ter- to a new study led by women with sisters who it, too, and healthcare minate their pregnancies.
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