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Drug-Induced Angle-Closure Glaucoma
10.5005/jp-journals-10008-1100 ArujREVIEW K Khurana ARTICLE et al Drug-induced Angle-Closure Glaucoma Aruj K Khurana, Bhawna Khurana, Ashok K Khurana Regional Institute of Ophthalmology, Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India Correspondence: Ashok K Khurana, Senior Professor, Regional Institute of Ophthalmology, Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India ABSTRACT Drug-induced angle-closure glaucoma is an important entity for the ophthalmologist as well as the general physician as it represents a preventable cause of potential blindness. This brief review highlights the fact that a high index of suspicion, in a susceptible individual followed by confirmation on appropriate imaging modality (UBM, ultrasound or anterior segment OCT) can alleviate the threat to sight and also help to institute appropriate therapy. Keywords: Acute angle closure, Drug-induced glaucoma. INTRODUCTION factors exist for this syndrome.9 Other sulfa-based drugs known Drug-induced angle-closure glaucoma is an important entity to be associated with AACG: Acetazolamide, hydrochloro- 10 for the ophthalmologist as well as the general physician as it thiazide and cotrimoxazole. represents a preventable cause of potential blindness.1 Acute Anticholinergic drugs implicated in the causation of AACG angle-closure glaucoma can develop in a susceptible individual include atropine, homatropine, cyclopentolate and ipratropium by various classes of drugs.2 Practitioners using any of these bromide.10,11 Atropine is often used to treat bradycardia, drugs should be aware of their potential to cause acute angle especially related to general anesthesia. Postoperative AACG closure, such that a patient presenting with signs or symptoms has been reported in patients after general anesthesia for of acute angle closure should be immediately referred to an abdominal, orthopedic, facial and endoscopic surgery.12 3 ophthalmologist. -
208135Orig1s000
CENTER FOR DRUG EVALUATION AND RESEARCH APPLICATION NUMBER: 208135Orig1s000 STATISTICAL REVIEW(S) U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research Office of Translational Sciences Office of Biostatistics S TATISTICAL R EVIEW AND E VALUATION CLINICAL STUDIES NDA/BLA #: 208135 Drug Name: Tetracaine Hydrochloride Ophthalmic Solution 0.5% (STERI-UNIT®) Indication(s): For procedures requiring a rapid and short acting ophthalmic anesthetic Applicant: Alcon research ltd Date(s): Stamp date: April 30, 2015 PDUFA date: February 29, 2016 Review Priority: Standard Biometrics Division: DBIV Statistical Reviewer: Abel Tilahun Eshete Concurring Reviewers: Yan Wang Medical Division: Ophthalmology Clinical Team: Medical Reviewer: Jennifer Harris Project Manager: Michael Puglisi Keywords: Topical anesthesia, Pain scores, Tetracaine . Reference ID: 3875889 Table of Contents 1 EXECUTIVE SUMMARY............................................................................................................................... 4 2 INTRODUCTION............................................................................................................................................. 6 2.1 OVERVIEW ................................................................................................................................................... 6 2.2 SUBMISSION HISTORY .................................................................................................................................. 6 2.3 -
Non-Steroidal Drug-Induced Glaucoma MR Razeghinejad Et Al 972
Eye (2011) 25, 971–980 & 2011 Macmillan Publishers Limited All rights reserved 0950-222X/11 www.nature.com/eye 1,2 1 1 Non-steroidal drug- MR Razeghinejad , MJ Pro and LJ Katz REVIEW induced glaucoma Abstract vision. The majority of drugs listed as contraindicated in glaucoma are concerned with Numerous systemically used drugs are CAG. These medications may incite an attack in involved in drug-induced glaucoma. Most those individuals with narrow iridocorneal reported cases of non-steroidal drug-induced angle.3 At least one-third of acute closed-angle glaucoma are closed-angle glaucoma (CAG). glaucoma (ACAG) cases are related to an Indeed, many routinely used drugs that have over-the-counter or prescription drug.1 Prevalence sympathomimetic or parasympatholytic of narrow angles in whites from the Framingham properties can cause pupillary block CAG in study was 3.8%. Narrow angles are more individuals with narrow iridocorneal angle. The resulting acute glaucoma occurs much common in the Asian population. A study of a more commonly unilaterally and only rarely Vietnamese population estimated a prevalence 4 bilaterally. CAG secondary to sulfa drugs is a of occludable angles at 8.5%. The reported bilateral non-pupillary block type and is due prevalence of elevated IOP months to years to forward movement of iris–lens diaphragm, after controlling ACAG with laser iridotomy 5,6 which occurs in individuals with narrow or ranges from 24 to 72%. Additionally, a open iridocorneal angle. A few agents, significant decrease in retinal nerve fiber layer including antineoplastics, may induce thickness and an increase in the cup/disc ratio open-angle glaucoma. -
Proxymetacaine Hydrochloride Ropivacaine Hydrochloride
1870 Local Anaesthetics Preparations pore: Alcaine; Switz.: Alcaine; Turk.: Alcaine; Opticaine; USA: Ak-Taine; Alcaine; Ocu-Caine; Ophthetic; Parcaine; Venez.: Alcaine; Oftaine†; Poen- (details are given in Part 3) caina. Proprietary Preparations CH3 Multi-ingredient: Spain: Detraine. O Multi-ingredient: Canad.: Fluoracaine†; USA: Fluoracaine; Fluorocaine. N CH3 O Quinisocaine Hydrochloride (BANM, rINNM) H3C Propipocaine (rINN) O Chinisocainum Hydrochloride; Dimethisoquin Hydrochloride Propipocaína; Propipocaïne; Propipocainum; Propoxypipero- (USAN); Dimethisoquinium Chloride; Hidrocloruro de quinisocaí- NH2 caine. 3-Piperidino-4′-propoxypropiophenone. na; Quinisocaïne, Chlorhydrate de; Quinisocaini Hydrochlori- (proxymetacaine) dum. 2-(3-Butyl-1-isoquinolyloxy)-NN-dimethylethylamine hy- Пропипокаин drochloride. C17H25NO2 = 275.4. Хинизокаина Гидрохлорид CAS — 3670-68-6. NOTE. PROX is a code approved by the BP 2008 for use on single unit doses of eye drops containing proxymetacaine hydrochlo- C17H24N2O,HCl = 308.8. ride where the individual container may be too small to bear all CAS — 86-80-6 (quinisocaine); 2773-92-4 (quinisocaine the appropriate labelling information. PROXFLN is a similar hydrochloride). O code approved for eye drops containing proxymetacaine hydro- ATC — D04AB05. chloride and fluorescein sodium. ATC Vet — QD04AB05. N Pharmacopoeias. In Br. and US. BP 2008 (Proxymetacaine Hydrochloride). A white or almost H3C CH3 white, odourless or almost odourless, crystalline powder. Soluble O in water and in chloroform; very soluble in dehydrated alcohol; N practically insoluble in ether. A 1% solution in water has a pH of O CH Profile 5.7 to 6.4. Protect from light. 3 Propipocaine is a local anaesthetic (p.1850) that has been used USP 31 (Proparacaine Hydrochloride). A white to off-white, or for surface anaesthesia. -
Anticholinergic Drugs and Dementia
DEMENTIA Q&A 24 Anticholinergic drugs and dementia Anticholinergics are a class of drug used to treat a wide variety of medical conditions. As with any medication, anticholinergics can have many beneficial effects, but these need to be balanced against a number of potential risks. This sheet provides information about how these drugs work as well as the impact that they may have in respect to dementia risk and cognitive functioning. What are anticholinergics? in time.4 It has been estimated that in Australia, 33% of people over the age of 65 years take enough Anticholinergics are generally used to inhibit the medications with anticholinergic effects to potentially involuntary movements of muscles or balance the increase their risk of harm.5 The use of anticholinergics production of various chemicals within the body. They is more common in older people because these drugs have been used in treating a wide variety of medical are prescribed for the symptomatic management of conditions including symptoms of psychosis (which medical conditions that often occur in later life. can be caused by bipolar disorder and schizophrenia), depression, urinary incontinence (e.g. overactive How do anticholinergic drugs work? bladder), gastrointestinal spasms, allergies, respiratory Anticholinergics are a class of drug that block the conditions (such as asthma and chronic obstructive action of acetylcholine in the nervous system, a pulmonary disease), Parkinson’s disease, conditions chemical (neurotransmitter) that is used to control concerning muscles in the eye and pupil dilation, messages travelling from one cell to another. They do nausea, sleep disorders and cardiovascular complaints this by blocking the binding of acetylcholine to its (slow heart rhythms) (Table 1).1,2 Some cold and flu receptor in the nerve cells. -
Pharmacology of Ophthalmic Agents
Ophthalmic Pharmacology Richard Alan Lewis M.D., M.S., PHARMACOLOGY FOPS PHARMACOKINETICS OF Professor, Departments of Ophthalmology, • The study of the absorption, OPHTHALMIC Medicine, Pediatrics, and Molecular distribution, metabolism, AGENTS and Human Genetics and excretion of a drug or and the National School of Tropical agent Introduction and Review Medicine Houston, Texas PHARMACOKINETICS Factors Affecting Drug Penetration Factors Affecting Drug Penetration into Ocular Tissues • A drug can be delivered to ocular tissue: into Ocular Tissues – Locally: • Drug concentration and solubility: The higher the concentration the better the penetration, • Surfactants: The preservatives in ocular • Eye drop but limited by reflex tearing. preparations alter cell membrane in the cornea • Ointment and increase drug permeability, e.g., • Viscosity: Addition of methylcellulose and benzalkonium and thiomersal • Periocular injection polyvinyl alcohol increases drug penetration by • pH: The normal tear pH is 7.4; if the drug pH is • Intraocular injection increasing the contact time with the cornea and altering corneal epithelium. much different, it will cause reflex tearing. – Systemically: • Lipid solubility: Because of the lipid rich • Drug tonicity: When an alkaloid drug is put in • Orally environment of the epithelial cell membranes, relatively alkaloid medium, the proportion of the uncharged form will increase, thus more • IM the higher lipid solubility, the more the penetration. • IV penetration. FLUORESCEIN FLUORESCEIN Chemistry Dosage ● C20H1205, brown crystal ● Adults: 500-750 mg IV ● M.W. 322.3 e.g., 3 cc 25% solution ● Peak absorption 485-500 nm. 5 cc 10% solution ● Peak emission 520-530 nm. ● Children: 1.5-2.5 mg/kg IV Richard Alan Lewis, M.D., M.S. -
Royal Free Hospital Drug Formulary
Royal Free Hospital Drug Formulary Title Formulary Status Section Annotation 5.3 Antiviral drugs‐>5.3.1 HIV infection‐>Nucleoside reverse ABACAVIR On Formulary transcriptase inhibitors As per HIV guidelines. Abidec® On Formulary 9.6 Vitamins‐>9.6.7 Multivitamin preparations 4.10 Drugs used in substance dependence‐>4.10.1 Alcohol ACAMPROSATE CALCIUM On Formulary dependence‐>Acamprosate 6.1 Drugs used in diabetes‐>6.1.2 Antidiabetic drugs‐>6.1.2.3 Other ACARBOSE On Formulary antidiabetic drugs 11.6 Treatment of glaucoma‐>Carbonic anhydrase inhibitors and ACETAZOLAMIDE On Formulary systemic drugs 11.8 Miscellaneous ophthalmic preparations‐>11.8.2 Ocular diagnostic and peri‐operative preparations and photodynamic ACETYLCHOLINE CHLORIDE On Formulary treatment‐>Ocular peri‐operative drugs ACETYLCYSTEINE On Formulary Specific drugs‐>Analgesics (non‐opioid) Acetylcysteine On Formulary Specific drugs‐>Analgesics (non‐opioid)‐>ACETYLCYSTEINE 11.8 Miscellaneous ophthalmic preparations‐>11.8.1 Tear deficiency, ACETYLCYSTEINE On Formulary ocular lubricants, and astringents ACICLOVIR On Formulary 11.3 Anti‐infective eye preparations‐>11.3.3 Antivirals ACICLOVIR On Formulary 13.10 Anti‐infective skin preparations‐>13.10.3 Antiviral preparations 13.10 Anti‐infective skin preparations‐>13.10.3 Antiviral preparations‐ Aciclovir On Formulary >ACICLOVIR 13.5 Preparations for eczema and psoriasis‐>13.5.2 Preparations for ACITRETIN On Formulary psoriasis‐>Oral retinoids for psoriasis Removal and elimination‐>Removal from the gastro‐intestinal tract‐ Actidose‐Aqua® -
Safety Alert: Risks Associated with Ophthalmic Anesthetics
WRHA Pharmacy Program Health Sciences Centre MS-189 820 Sherbrook St. Winnipeg, Manitoba R3A 1R9 CANADA TEL: 204-787-7183 Fax: 204-787-3195 FAX: 204-787-3195 Safety Alert: Risks associated with Ophthalmic Anesthetics The self-administration of ophthalmic anesthetics by patients for the relief of eye pain should be avoided and they should not be given to patients to take home for pain relief. Vision threatening complications of topical anesthetic abuse are common. There is no indication for the use of ophthalmic anesthetics except for diagnostic and short term therapeutic purposes (the removal of a foreign body or ocular surgery) and therefore, these products should only be used under a physician’s supervision. Eye trauma resulting in a corneal abrasion (epithelial injury) is a common complaint in the Emergency department (1). A superficial corneal injury can cause intense pain causing a patient to seek medical help or immediate relief from available over the counter remedies. In Canada, only two topical ophthalmic anesthetic drugs are available commercially as single entities, proparacaine (proxymetacaine) and tetracaine (available in bottle and minim forms). Benoxinate (oxybuprocaine) is only available in combination with fluorescein (3). Lidocaine is also used in ophthalmic surgical procedures however, it is not available in the Canadian market as an ophthalmic preparation. Topical ophthalmic anesthetics function by blocking nerve conduction when applied to the cornea and conjunctiva. The ocular surface is innervated by the multiple branches of the trigeminal nerve. The cornea is supplied by the long and short ciliary nerves, the nasociliary nerve and the lacrimal nerve (4). Topical anesthetics reduce sodium permeability preventing generation and conduction of nerve impulses, increasing excitation threshold, and slowing the nerve impulse propagation. -
Local Anesthetics – Substances with Multiple Application in Medicine
ISSN 2411-958X (Print) European Journal of January-April 2016 ISSN 2411-4138 (Online) Interdisciplinary Studies Volume 2, Issue 1 Local Anesthetics – Substances with Multiple Application in Medicine Rodica SÎRBU Ovidius University of Constanta, Faculty of Pharmacy, Campus Corp B, University Alley No. 1, Constanta, Romania Emin CADAR UMF Carol Davila Bucharest, Faculty of Pharmacy, Str. Traian Vuia No. 6, Sector 2, Bucharest, Romania Cezar Laurențiu TOMESCU Ovidius University of Constanta, Faculty of Medicine, Campus Corp B, University Alley No. 1, Constanta, Romania Cristina-Luiza ERIMIA Corresponding author, [email protected] Ovidius University of Constanta, Faculty of Pharmacy, Campus Corp B, University Alley No. 1, Constanta, Romania Stelian PARIS Ovidius University of Constanta, Faculty of Pharmacy, Campus Corp B, University Alley No. 1, Constanta, Romania Aneta TOMESCU Ovidius University of Constanta, Faculty of Medicine, Campus Corp B, University Alley No. 1, Constanta, Romania Abstract Local anesthetics are substances which, by local action groups on the runners, cause loss of reversible a painful sensation, delimited corresponding to the application. They allow small surgery, short in duration and the endoscopic maneuvers. May be useful in soothe teething pain of short duration and in the locking of the nervous disorders in medical care. Local anesthesia is a process useful for the carrying out of surgery and of endoscopic maneuvers, to soothe teething pain in certain conditions, for depriving the temporary structures peripheral nervous control. Reversible locking of the transmission nociceptive, the set of the vegetative and with a local anesthetic at the level of the innervations peripheral nerve, roots and runners, a trunk nervous, around the components of a ganglion or coolant is cefalorahidian practice anesthesia loco-regional. -
Topical Treatments of Skin Pain Associated with Hidradenitis Supprurativa
UC Davis Dermatology Online Journal Title Topical treatments of skin pain: a general review with a focus on hidradenitis suppurativa with topical agents Permalink https://escholarship.org/uc/item/4m57506k Journal Dermatology Online Journal, 20(7) Author Scheinfeld, Noah Publication Date 2014 DOI 10.5070/D3207023131 License https://creativecommons.org/licenses/by-nc-nd/4.0/ 4.0 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Volume 20 Number 7 July 2014 Review Topical treatments of skin pain: a general review with a focus on hidradenitis suppurativa with topical agents Noah Scheinfeld MD JD Dermatology Online Journal 20 (7): 3 Assistant Clinical Professor of Dermatology Weil Cornel Medical College Correspondence: Noah Scheinfeld 150 West 55th Street NYC NY 10019 (212) 991-6490 [email protected] Abstract Hidradenitis Supprurativa (HS) is a painful chronic follicular disease. Few papers have addressed pain control for this debilitating condition. Possible topical agents include tricyclic antidepressants, opioids, anticonvulsants, NSAIDs, NMDA receptor antagonists, local anesthetics and other agents. The first line agents for the topical treatment of the cutaneous pain of HS are diclonefac gel 1% and liposomal xylocaine 4% and 5% cream or 5% ointment. The chief advantage of topical xylocaine is that is quick acting i.e. immediate however with a limited duration of effect 1-2 hours. The use of topical ketamine, which blocks n- methyl-D-aspartate receptors in a non-competitive fashion, might be a useful tool for the treatment of HS pain. Topical doxepin, which available in a 5% commercially preparation (Zonalon®) , makes patients drowsy and is not useful for controlling the pain of HS . -
Estonian Statistics on Medicines 2016 1/41
Estonian Statistics on Medicines 2016 ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day A ALIMENTARY TRACT AND METABOLISM 167,8985 A01 STOMATOLOGICAL PREPARATIONS 0,0738 A01A STOMATOLOGICAL PREPARATIONS 0,0738 A01AB Antiinfectives and antiseptics for local oral treatment 0,0738 A01AB09 Miconazole (O) 7088 g 0,2 g 0,0738 A01AB12 Hexetidine (O) 1951200 ml A01AB81 Neomycin+ Benzocaine (dental) 30200 pieces A01AB82 Demeclocycline+ Triamcinolone (dental) 680 g A01AC Corticosteroids for local oral treatment A01AC81 Dexamethasone+ Thymol (dental) 3094 ml A01AD Other agents for local oral treatment A01AD80 Lidocaine+ Cetylpyridinium chloride (gingival) 227150 g A01AD81 Lidocaine+ Cetrimide (O) 30900 g A01AD82 Choline salicylate (O) 864720 pieces A01AD83 Lidocaine+ Chamomille extract (O) 370080 g A01AD90 Lidocaine+ Paraformaldehyde (dental) 405 g A02 DRUGS FOR ACID RELATED DISORDERS 47,1312 A02A ANTACIDS 1,0133 Combinations and complexes of aluminium, calcium and A02AD 1,0133 magnesium compounds A02AD81 Aluminium hydroxide+ Magnesium hydroxide (O) 811120 pieces 10 pieces 0,1689 A02AD81 Aluminium hydroxide+ Magnesium hydroxide (O) 3101974 ml 50 ml 0,1292 A02AD83 Calcium carbonate+ Magnesium carbonate (O) 3434232 pieces 10 pieces 0,7152 DRUGS FOR PEPTIC ULCER AND GASTRO- A02B 46,1179 OESOPHAGEAL REFLUX DISEASE (GORD) A02BA H2-receptor antagonists 2,3855 A02BA02 Ranitidine (O) 340327,5 g 0,3 g 2,3624 A02BA02 Ranitidine (P) 3318,25 g 0,3 g 0,0230 A02BC Proton pump inhibitors 43,7324 A02BC01 Omeprazole -
Additional Drug Coverage
Additional Drug Coverage Additional prescription drug coverage Your plan includes extra coverage for certain drugs and supplies as shown below. This is not a complete list of prescription drugs and supplies covered by our plan. For a complete list, please call Customer Service toll-free at (866) 868-0609 (TTY: 711), 7 a.m. – 7 p.m. CT, Monday – Friday and 7 a.m. – 3 p.m. CT, Saturday. Lower-cost Medicare prescription drugs and supplies Your plan covers some of your Medicare prescription drugs and supplies at a $0 copay. If you have questions, call us toll-free at (866) 868-0609 (TTY: 711), 7 a.m. – 7 p.m. CT, Monday – Friday and 7 a.m. – 3 p.m. CT, Saturday. These drugs and supplies are part of your Medicare prescription drug coverage.1 Breast cancer preventive medications PEG-3350/NaCl/Na Bicarbonate/KCl TriLyte Anastrozole Exemestane Certain diabetic supplies for the Raloxifene administration of insulin Tamoxifen Insulin Syringes & Pen Needles Certain cholesterol-lowering medications Shingles vaccine Atorvastatin 10mg & 20mg Tablet Shingrix Lovastatin 10mg, 20mg & 40mg Tablet Zostavax Simvastatin 5mg, 10mg, 20mg & 40mg Tablet Tobacco cessation medications Certain colon prep products Buproban 150mg GaviLyte-C Chantix GaviLyte-G Nicotrol Inhaler PEG-3350/Electrolytes Nicotrol Nasal Spray Y0066_200527_081500_C Lower-cost non-Medicare over-the-counter drugs These drugs are covered in addition to the drugs in your plan’s drug list (formulary).2 Your plan covers these over-the-counter drugs at a $0 copay. Certain colon preparation products Tobacco cessation medications Bisacodyl Tablets Nicotine Gum Magnesium Citrate Solution Nicotine Lozenges Polyethylene Glycol Powder Nicotine Patches 1Information about the appeals and grievance process for these prescription drugs and supplies can be found in your Evidence of Coverage.