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Preventing Overdiagnosis Conference Abstracts Dartmouth College September 10-12, 2013 Abstracts Are Hyperlinked
Preventing Overdiagnosis Conference Abstracts Dartmouth College September 10-12, 2013 Abstracts are hyperlinked. Select abstract, click on it to go to chosen abstract Table of Contents Abstract#1 - THE MARMOT REPORT AND THE HAZARDS OF THE OVER-DIAGNOSIS OF BREAST CANCER .............................................................................................................................. 2 Abstract # 3 - DO PHYSICIAN SEARCHES FOR CLINICAL INFORMATION HELP TO AVOID UNNECESSARY DIAGNOSTIC TESTS, TREATMENTS OR SPECIALIST REFERRALS? ................ 3 Abstract #4 - REDUCING OVERDIAGNOSIS BY ELICITING PATIENTS’ PREFERENCES ABOUT ACCEPTABLE REGRET OF DIAGNOSTIC TESTING ......................................................................... 4 Abstract # 5 - DRIVERS FOR DIAGNOSIS OF MENTAL ILLNESS - AN ETHICAL ANALYSIS ....... 4 Abstract #6 - OVERDIAGNOSIS OF GONORRHOEA IN TREATMENT GUIDELINES FOR PELVIC INFLAMMATORY DISEASE (PID) – A RECIPE FOR RESISTANCE? ................................................. 6 Abstract # 7 - PSA-TESTING AND PROSTATIC CANCER IN DIFFERENT COUNTIES IN NORWAY – VARIATION AND OVERDIAGNOSIS ................................................................................................ 7 Abstract #8 - OVERCOMING OVERTREATMENT IN THYROID CANCER ....................................... 8 Abstract #10 - AN APPROACH TO CURB THE OVER-ORDERING OF AST, A DIAGNOSTICALLY NONSPECIFIC ENZYME ...................................................................................................................... 9 Abstract # -
Accounting for Variation in and Overuse of Antibiotics Among Humans
Received: 27 June 2020 Revised: 4 October 2020 Accepted: 6 October 2020 DOI: 10.1002/bies.202000163 PROBLEMS & PARADIGMS Prospects & Overviews Accounting for variation in and overuse of antibiotics among humans Martin J. Blaser1 Melissa K. Melby2 Margaret Lock3 Mark Nichter4 1 Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey, USA 2 Department of Anthropology, University of Delaware, Newark, Delaware, USA 3 Department of Social Studies of Medicine and Department of Anthropology, McGill University, Montreal, Quebec, Canada 4 School of Anthropology, Mel and Enid Zuckerman College of Public Health, Department of Family Medicine, University of Arizona, Tucson, Arizona, USA Correspondence Martin J. Blaser, Center for Advanced Abstract Biotechnology and Medicine, Rutgers University, Piscataway NJ 08854, USA. Worldwide, antibiotic use is increasing, but many infections against which antibi- Email: [email protected] otics are applied are not even caused by bacteria. Over-the-counter and internet sales Mark Nichter, School of Anthropology, Mel and Enid Zuckerman College of Public Health, preclude physician oversight. Regional differences, between and within countries high- Department of Family Medicine, University of light many potential factors influencing antibiotic use. Taking a systems perspective Arizona, Tucson AZ 85721 Email: [email protected] that considers pharmaceutical commodity chains, we examine antibiotic overuse from the vantage point of both sides of the therapeutic relationship. We examine patterns Funding information and expectations of practitioners and patients, institutional policies and pressures, the Fondation Leducq; Canadian Institute for Advanced Research; C & D Funds; National business strategies of pharmaceutical companies and distributors, and cultural drivers Institutes of Health, Grant/Award Number: of variation. -
Antibiotic Use Guidelines for Companion Animal Practice (2Nd Edition) Iii
ii Antibiotic Use Guidelines for Companion Animal Practice (2nd edition) iii Antibiotic Use Guidelines for Companion Animal Practice, 2nd edition Publisher: Companion Animal Group, Danish Veterinary Association, Peter Bangs Vej 30, 2000 Frederiksberg Authors of the guidelines: Lisbeth Rem Jessen (University of Copenhagen) Peter Damborg (University of Copenhagen) Anette Spohr (Evidensia Faxe Animal Hospital) Sandra Goericke-Pesch (University of Veterinary Medicine, Hannover) Rebecca Langhorn (University of Copenhagen) Geoffrey Houser (University of Copenhagen) Jakob Willesen (University of Copenhagen) Mette Schjærff (University of Copenhagen) Thomas Eriksen (University of Copenhagen) Tina Møller Sørensen (University of Copenhagen) Vibeke Frøkjær Jensen (DTU-VET) Flemming Obling (Greve) Luca Guardabassi (University of Copenhagen) Reproduction of extracts from these guidelines is only permitted in accordance with the agreement between the Ministry of Education and Copy-Dan. Danish copyright law restricts all other use without written permission of the publisher. Exception is granted for short excerpts for review purposes. iv Foreword The first edition of the Antibiotic Use Guidelines for Companion Animal Practice was published in autumn of 2012. The aim of the guidelines was to prevent increased antibiotic resistance. A questionnaire circulated to Danish veterinarians in 2015 (Jessen et al., DVT 10, 2016) indicated that the guidelines were well received, and particularly that active users had followed the recommendations. Despite a positive reception and the results of this survey, the actual quantity of antibiotics used is probably a better indicator of the effect of the first guidelines. Chapter two of these updated guidelines therefore details the pattern of developments in antibiotic use, as reported in DANMAP 2016 (www.danmap.org). -
Evaluation of Antibiotic Awareness Campaigns
WHO Collaborating Centre on Patient Safety The University of Geneva Hospitals and Faculty of Medicine 4, Rue Gabrielle Perret-Gentil 1211 Geneva, Switzerland Evaluation of antibiotic awareness campaigns Report prepared by Mirko Saam, Benedikt Huttner and Stephan Harbarth1 for World Health Organization Expert Committee on the Selection and Use of Essential Medicines Policy, Access and Use (PAU) Department of Essential Medicines and Health Products 20, Avenue Appia 1211 Geneva 27, Switzerland 1 [email protected]; [email protected]; [email protected] 1 SUMMARY 1 INTRODUCTION 2 KEY FINDINGS OF THE SURVEY 3 OUTLINE OF SURVEYED CAMPAIGNS 3 TARGET AUDIENCES 5 INFECTIONS TARGETED 7 KEY MESSAGES AND ESSENTIAL PUBLIC SLOGANS 8 GLOBAL VERSUS LOCAL KEY MESSAGES 11 “NEW” KEY MESSAGES IDENTIFIED 12 INTERVENTIONS USED IN THE CAMPAIGNS 13 EVALUATION OF THE CAMPAIGNS 14 OBSTACLES FACED WHILE IMPLEMENTING A PUBLIC AWARENESS CAMPAIGN 15 POTENTIAL FOR EXPANSION IN NEW DIRECTIONS 15 ACKNOWLEDGMENTS 17 APPENDIX I - METHODOLOGY I APPENDIX II - SUMMARY TABLE I APPENDIX III - QUESTIONNAIRE USED FOR THE SURVEY I REFERENCES 18 2 SUMMARY ● Between September and November 2016, we conducted an online survey to review the characteristics of public awareness campaigns targeting antibiotic use conducted since 2010. We identified 60 campaigns implemented on a national (n=42, 70%), regional (14, 23%) or both levels simultaneously (2, 2%), across 16 low- and middle- income countries (LMICs), and 31 high-income countries. Respondents from another 8 countries (5 LMICs and 3 high-income countries) either stated they were not sure, or that there was no such campaign in their country. Among the 93 countries that were contacted, 38 (40%) did not respond at all. -
Trends in Antibiotic Self-Medication for Dental Pathologies Among Patients in the Dominican Republic: a Cross-Sectional Study
Journal of Clinical Medicine Article Trends in Antibiotic Self-Medication for Dental Pathologies among Patients in the Dominican Republic: A Cross-Sectional Study Juan Manuel Aragoneses 1, Javier Aragoneses 2 , Cinthia Rodríguez 3, Juan Algar 4 and Ana Suárez 5,* 1 Faculty of Dentistry, Universidad Alfonso X El Sabio, 28691 Madrid, Spain; [email protected] 2 Department of Medicine and Medical Specialties, Faculty of Health Sciences, University of Alcalá, 28801 Madrid, Spain; [email protected] 3 Department of Dentistry, Universidad Federico Henriquez y Carvajal, Santo Domingo 10106, Dominican Republic; [email protected] 4 Department of Clinical Dentistry, School of Biomedical Sciences, Universidad Europea de Madrid, 28005 Madrid, Spain; [email protected] 5 Department of Preclinical Dentistry, School of Biomedical Sciences, Universidad Europea de Madrid, 28670 Madrid, Spain * Correspondence: [email protected] Abstract: The World Health Organisation has warned of the increase in antibiotic resistance, esti- mating that by 2050 it could become the leading cause of death worldwide. Several studies and literature reviews show a correlation between antibiotic use and bacterial resistance, with unnecessary broad-spectrum antibiotics, such as amoxicillin/clavulanic acid and azithromycin, being one of the main causative factors. An interview-based survey of 2160 participants was conducted to assess the Citation: Aragoneses, J.M.; prevalence in the practice of self-medication with antibiotics among dental patients in the Dominican Aragoneses, J.; Rodríguez, C.; Algar, Republic. A series of open-ended questions regarding self-medication and class of antibiotics were J.; Suárez, A. Trends in Antibiotic put to the patients. Over a third of the study population (39.7%) admitted to the practice of antibiotic Self-Medication for Dental Pathologies among Patients in the self-medication. -
Situation Report on the Active Substance Amoxicillin
INSPECTION DIVISION Starting materials inspection division Date: 30/03/2016 Version: 1 public Status: Final SITUATION REPORT ON THE ACTIVE SUBSTANCE AMOXICILLIN I. INTRODUCTION .................................................................................................................................. 2 II. BACKGROUND .................................................................................................................................. 3 III. APPLICABLE REGULATIONS/GUIDELINES IN FORCE ................................................................ 3 IV. AMOXICILLIN SUPPLY .................................................................................................................... 3 IV.1. Process for obtaining amoxicillin ................................................................................................ 3 IV.2. Sources of supply of medicinal product manufacturing sites in France ..................................... 5 V. EVALUATION OF AMOXICILLIN MANUFACTURERS BY PHARMACEUTICAL SITE .................. 8 VI. REVIEW OF RECENT INSPECTIONS .............................................................................................. 8 VI.1. Collaboration between competent authorities ............................................................................ 8 VI.2. Monitoring of amoxicillin (sodium or trihydrate) manufacturing sites by international authorities since 2010 .......................................................................................................................................... -
Employment and Activity Limitations Among Adults with Chronic Obstructive Pulmonary Disease — United States, 2013
Morbidity and Mortality Weekly Report Weekly / Vol. 64 / No. 11 March 27, 2015 Employment and Activity Limitations Among Adults with Chronic Obstructive Pulmonary Disease — United States, 2013 Anne G. Wheaton, PhD1, Timothy J. Cunningham, PhD1, Earl S. Ford, MD1, Janet B. Croft, PhD1 (Author affiliations at end of text) Chronic obstructive pulmonary disease (COPD) is a group a random-digit–dialed telephone survey (landline and cell of progressive respiratory conditions, including emphysema phone) of noninstitutionalized civilian adults aged ≥18 years and chronic bronchitis, characterized by airflow obstruction that includes various questions about respondents’ health and and symptoms such as shortness of breath, chronic cough, risk behaviors. Response rates for BRFSS are calculated using and sputum production. COPD is an important contributor standards set by the American Association of Public Opinion to mortality and disability in the United States (1,2). Healthy Research Response Rate Formula #4.† The response rate is the People 2020 has several COPD-related objectives,* including number of respondents who completed the survey as a pro- to reduce activity limitations among adults with COPD. To portion of all eligible and likely eligible persons. The median assess the state-level prevalence of COPD and the associa- survey response rate for all states, territories, and DC in 2013 tion of COPD with various activity limitations among U.S. was 46.4%, and ranged from 29.0% to 60.3%. Additional adults, CDC analyzed data from the 2013 Behavioral Risk information is presented in the BRFSS 2013 Summary Data Factor Surveillance System (BRFSS). Among U.S. adults in Quality Report.§ all 50 states, the District of Columbia (DC), and two U.S. -
The Selection and Use of Essential Medicines
WHO Technical Report Series 1006 The Selection and Use of Essential Medicines Report of the WHO Expert Committee, 2017 (including the 20th WHO Model List of Essential Medicines and the 6th Model List of Essential Medicines for Children) WHO Technical Report Series 1006 The Selection and Use of Essential Medicines Report of the WHO Expert Committee, 2017 (including the 20th WHO Model List of Essential Medicines and the 6th WHO Model List of Essential Medicines for Children) This report contains the collective views of an international group of experts and does not necessarily represent the decisions or the stated policy of the World Health Organization The selection and use of essential medicines: report of the WHO Expert Committee, 2017 (including the 20th WHO model list of essential medicines and the 6th WHO model list of essential medicines for children). (WHO technical report series ; no. 1006) ISBN 978-92-4-121015-7 ISSN 0512-3054 © World Health Organization 2017 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial- ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. -
Together, Let's Save Antibiotics
TOGETHER, LET’S SAVE ANTIBIOTICS Proposals of the special working group for keeping antibiotics effective Together, let’s save antibiotics Written by : Dr Jean CARLET and Pierre LE COZ 2 TOGETHER, LET’S SAVE ANTIBIOTICS REPORT FROM THE SPECIAL WORKING GROUP FOR KEEPING ANTIBIOTICS EFFECTIVE June 2015 TOGETHER, LET’S SAVE ANTIBIOTICS 3 Acknowledgements My sincere thanks go first and foremost to Marisol Touraine, the French Minister of Social Affairs, Health and Women’s Rights, for entrusting me with this assignment. I would also like to thank the cabinet ministers, especially Professor Djillali Annane and Dr Jérôme Salomon for their well-informed advice. I am grateful to Professor Benoît Vallet, Director-General for Health, for his encouragements throughout this assignment, and to Dr Marie-Hélène Loulergue, Deputy-Director of Infection Risk Prevention, her assistant Dr Bernadette Worms and their team for their warm welcome. I would like to highlight the involvement and commitment of the working group coordinators, Dr Bruno Coignard, Deputy Director of the Department of Infectious Diseases at the French Institute for Public Health Surveillance (InVS), Professor Céline Pulcini, infectious diseases consultant at Nancy Teaching Hospital (CHU), Ms Claude Rambaud, Vice-President of the Collectif Inter-associatif Sur la Santé (CISS), Mr Alain-Michel Ceretti, Founder and Chairman of LIEN, Professor Jocelyne Arquembourg, lecturer at the University of Paris III – Sorbonne Nouvelle, Ms Florence Séjourné, Managing Director of the biotech Da Volterra, -
Call for More Research to Contain Antimicrobial Resistance Waleed M
Sweileh Globalization and Health (2021) 17:94 https://doi.org/10.1186/s12992-021-00754-9 RESEARCH Open Access Global research publications on irrational use of antimicrobials: call for more research to contain antimicrobial resistance Waleed M. Sweileh Abstract Background: Irrational use of antimicrobials is highly prevalent. It is a major driving factor for antimicrobial resistance (AMR). Research on irrational antimicrobial use is important for developing policies and regulations to combat and contain AMR. The present study aims to provide an overview of research publications on the irrational use of antimicrobials at the national and global levels. Methods: Publications on irrational use of antimicrobials were extracted from Scopus using a wide range of relevant keywords for the study period from 1980 to 2020. Results: In total, 656 publications on irrational use of antimicrobials were found. The bulk of publications in this field were about irrational use in humans. A limited number of publications were found on the irrational use of antimicrobials in the context of veterinary and environment. The number of publications, contributing countries, and the mean number of authors per article increased with time, most notably in the last decade. Authors from 105 different countries participated in publishing the retrieved articles with 22 (21.0%) participated in 10 or more publications. The United States led with 140 (21.6%) articles followed distantly by China (n = 49, 7.5%), India (n = 45, 6.9%), and the United Kingdom (n = 45, 6.9%). Countries in the South-East Asian region (n = 69, 10.5%) and the African region (n = 42, 6.4%) made the least contribution. -
Towards a New Global Business Model for Antibiotics
Towards a New Global Business Model for Antibiotics Global Business Model for a New Towards Chatham House Report Edited by Charles Clift, Unni Gopinathan, Chantal Morel, Kevin Outterson, John-Arne Røttingen and Anthony So Towards a New Global Business Model for Antibiotics Edited by Charles Clift, Gopinathan, and Anthony John-ArneSo Outterson, Charles Chantal Unni Kevin Røttingen by Morel, Edited Delinking Revenues from Sales Report from the Chatham House Working Group on New Antibiotic Business Models Chatham House Chatham House Report Edited by Charles Clift, Unni Gopinathan, Chantal Morel, Kevin Outterson, John-Arne Røttingen and Anthony So October 2015 Towards a New Global Business Model for Antibiotics Delinking Revenues from Sales Report from the Chatham House Working Group on New Antibiotic Business Models Chatham House, the Royal Institute of International Affairs, is an independent policy institute based in London. Our mission is to help build a sustainably secure, prosperous and just world. The Royal Institute of International Affairs Chatham House 10 St James’s Square London SW1Y 4LE T: +44 (0) 20 7957 5700 F: + 44 (0) 20 7957 5710 www.chathamhouse.org Charity Registration No. 208223 © The Royal Institute of International Affairs, 2015 Chatham House, the Royal Institute of International Affairs, does not express opinions of its own. The opinions expressed in this publication are the responsibility of the authors. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical including photocopying, recording or any information storage or retrieval system, without the prior written permission of the copyright holder. -
Antibiotic Stewardship
CME Infectious diseases Clinical Medicine 2013, Vol 13, No 5: 499–503 28 Department of Health Advisory Committee encompass initiatives that promote the on Antimicrobial Resistance and Healthcare Antibiotic responsible use of antibiotics, with the goal of Associated Infection. Antimicrobial steward- preserving their future effectiveness and safe- ship: ‘Start smart – then focus’. London: DH, stewardship 4–7 2011. www.gov.uk/government/uploads/ guarding public health. The physician may system/uploads/attachment_data/file/215308/ perceive the concept of stewardship as pat- dh_131181.pdf [Accessed 5 August 2013]. Kieran Hand, consultant pharmacist for ronising or insulting and a threat to clinical anti-infectives and post-doctoral clinical freedom; nonetheless, physicians in the USA academic fellow have recently called for mandatory imple- Address for correspondence: mentation of antibiotic stewardship backed Dr RA Seaton, Brownlee Centre for University Hospital Southampton NHS Foundation Trust by legislation.8 This article sets out the case Infectious Diseases, Gartnavel General for antibiotic stewardship and describes com- Hospital, 1053 Great Western Road, monly used stewardship strategies and the Glasgow G12 0YN. Introduction evidence supporting their effectiveness. Email: [email protected] Sir Frank MacFarlane Burnet, winner of the Nobel Prize for Medicine in 1960, wrote of the Misuse of antibiotics decline of infectious diseases in 1962: ‘One can Antibiotic misuse (Table 1) is common in the think of the middle of the twentieth