Analysis the Structure of SAM and Cracking Password Base on Windows Operating System
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DECIPHER: Harnessing Local Sequence Context to Improve Protein Multiple Sequence Alignment Erik S
Wright BMC Bioinformatics (2015) 16:322 DOI 10.1186/s12859-015-0749-z RESEARCH ARTICLE Open Access DECIPHER: harnessing local sequence context to improve protein multiple sequence alignment Erik S. Wright1,2 Abstract Background: Alignment of large and diverse sequence sets is a common task in biological investigations, yet there remains considerable room for improvement in alignment quality. Multiple sequence alignment programs tend to reach maximal accuracy when aligning only a few sequences, and then diminish steadily as more sequences are added. This drop in accuracy can be partly attributed to a build-up of error and ambiguity as more sequences are aligned. Most high-throughput sequence alignment algorithms do not use contextual information under the assumption that sites are independent. This study examines the extent to which local sequence context can be exploited to improve the quality of large multiple sequence alignments. Results: Two predictors based on local sequence context were assessed: (i) single sequence secondary structure predictions, and (ii) modulation of gap costs according to the surrounding residues. The results indicate that context-based predictors have appreciable information content that can be utilized to create more accurate alignments. Furthermore, local context becomes more informative as the number of sequences increases, enabling more accurate protein alignments of large empirical benchmarks. These discoveries became the basis for DECIPHER, a new context-aware program for sequence alignment, which outperformed other programs on largesequencesets. Conclusions: Predicting secondary structure based on local sequence context is an efficient means of breaking the independence assumption in alignment. Since secondary structure is more conserved than primary sequence, it can be leveraged to improve the alignment of distantly related proteins. -
Logs & Event Analysis and Password Cracking
Logs & Event Analysis and Password Cracking MODULE 6 Page 1 of 29 Contents 6.1 Learning Objectives ............................................................................................................. 4 6.2 Introduction .......................................................................................................................... 4 6.3 Windows registry ................................................................................................................. 5 6.3.1 Registry and forensics ................................................................................................... 5 6.3.1.1 System information ................................................................................................ 5 6.4 Windows event log file ........................................................................................................ 9 6.4.1 Windows Event Log File Format .................................................................................. 9 6.4.2 Reading from Windows event log file ........................................................................ 11 6.4.3 Using Microsoft log parser ......................................................................................... 11 6.4.4 Understanding Windows user account management logs .......................................... 13 6.4.5 Understanding Windows file and other object Access sets ........................................ 14 6.4.6 Auditing policy change .............................................................................................. -
Decipher Prostate Cancer Classifier
Lab Management Guidelines v2.0.2019 Decipher Prostate Cancer Classifier MOL.TS.294.A v2.0.2019 Procedures addressed The inclusion of any procedure code in this table does not imply that the code is under management or requires prior authorization. Refer to the specific Health Plan's procedure code list for management requirements. Procedures addressed by this Procedure codes guideline Decipher Prostate Cancer Classifier 81479 What are gene expression profiling tests for prostate cancer Definition Prostate cancer (PC) is the most common cancer and a leading cause of cancer- related deaths worldwide. It is considered a heterogeneous disease with highly variable prognosis.1 High-risk prostate cancer (PC) patients treated with radical prostatectomy (RP) undergo risk assessment to assess future disease prognosis and determine optimal treatment strategies. Post-RP pathology findings, such as disease stage, baseline Gleason score, time of biochemical recurrence (BCR) after RP, and PSA doubling- time, are considered strong predictors of disease-associated metastasis and mortality. Following RP, up to 50% of patients have pathology or clinical features that are considered at high risk of recurrence and these patients usually undergo post-RP treatments, including adjuvant or salvage therapy or radiation therapy, which can have serious risks and complications. According to clinical practice guideline recommendations, high risk patients should undergo 6 to 8 weeks of radiation therapy (RT) following RP. However, approximately 90% of high-risk patients -
Comparing Tools for Non-Coding RNA Multiple Sequence Alignment Based On
Downloaded from rnajournal.cshlp.org on September 26, 2021 - Published by Cold Spring Harbor Laboratory Press ES Wright 1 1 TITLE 2 RNAconTest: Comparing tools for non-coding RNA multiple sequence alignment based on 3 structural consistency 4 Running title: RNAconTest: benchmarking comparative RNA programs 5 Author: Erik S. Wright1,* 6 1 Department of Biomedical Informatics, University of Pittsburgh (Pittsburgh, PA) 7 * Corresponding author: Erik S. Wright ([email protected]) 8 Keywords: Multiple sequence alignment, Secondary structure prediction, Benchmark, non- 9 coding RNA, Consensus secondary structure 10 Downloaded from rnajournal.cshlp.org on September 26, 2021 - Published by Cold Spring Harbor Laboratory Press ES Wright 2 11 ABSTRACT 12 The importance of non-coding RNA sequences has become increasingly clear over the past 13 decade. New RNA families are often detected and analyzed using comparative methods based on 14 multiple sequence alignments. Accordingly, a number of programs have been developed for 15 aligning and deriving secondary structures from sets of RNA sequences. Yet, the best tools for 16 these tasks remain unclear because existing benchmarks contain too few sequences belonging to 17 only a small number of RNA families. RNAconTest (RNA consistency test) is a new 18 benchmarking approach relying on the observation that secondary structure is often conserved 19 across highly divergent RNA sequences from the same family. RNAconTest scores multiple 20 sequence alignments based on the level of consistency among known secondary structures 21 belonging to reference sequences in their output alignment. Similarly, consensus secondary 22 structure predictions are scored according to their agreement with one or more known structures 23 in a family. -
Lotus Notes and Domino R5.0 Security Infrastructure Revealed
CT6TPNAwhite.qxd 4/28/99 4:00 PM Page 1 Lotus Notes and Domino R5.0 Security Infrastructure Revealed Søren Peter Nielsen, Frederic Dahm, Marc Lüscher, Hidenobu Yamamoto, Fiona Collins, Brian Denholm, Suresh Kumar, John Softley International Technical Support Organization http://www.redbooks.ibm.com SG24-5341-00 44 Lotus Notes and Domino R5.0 Security Infrastructure Revealed SG24-5341-00 International Technical Support Organization Lotus Notes and Domino R5.0 Security Infrastructure Revealed May 1999 Take Note! Before using this information and the product it supports, be sure to read the general information in the Special Notices section at the back of this book. First Edition (May 1999) This edition applies to Lotus Domino Release 5.0. Comments may be addressed to: IBM Corporation, International Technical Support Organization Dept. JN9B Building 045 Internal Zip 2834 11400 Burnet Road Austin, Texas 78758-3493 When you send information to IBM, you grant IBM a non-exclusive right to use or distribute the information in any way it believes appropriate without incurring any obligation to you. © International Business Machines Corporation 1999. All rights reserved. Note to U.S. Government Users: Documentation related to restricted rights. Use, duplication or disclosure is subject to restrictions set forth in GSA ADP Schedule Contract with IBM Corp. Contents Preface ....................... vii 2 What Is Lotus Domino? ........21 The Team That Wrote This Redbook ...... viii Domino R5.0 Server .................21 Comments Welcome ................. x Lotus QuickPlace .................21 1 Basic Security Concepts Domino Mail Server ...............22 Revealed ....................... 1 Domino Application Server ...........22 Important Terminology ............... 2 Domino Enterprise Server ............22 Computer System ................ -
Microsoft Windows NT
Microsoft Windows NT Securing Windows NT Installation October 23, 1997 Microsoft Corporation Contents Abstract Establishing Computer Security Levels of Security Off-the-Shelf vs. Custom Software Minimal Security Standard Security High-Level Security High-Level Software Security Considerations User Rights Protecting Files and Directories Protecting the Registry Secure EventLog Viewing Secure Print Driver Installation The Schedule Service (AT Command) Secure File Sharing FTP Service NetBios Access From Internet Hiding the Last User Name Restricting the Boot Process Allowing Only Logged-On Users to Shut Down the Computer Controlling Access to Removable Media Securing Base System Objects Enabling System Auditing Enhanced Protection for Security Accounts Manager Database Restricting Anonymous network access to Registry Restricting Anonymous network access to lookup account names and groups and network shares Enforcing strong user passwords Disabling LanManager Password Hash Support Wiping the System Page File during clean system shutdown Disable Caching of Logon Credentials during interactive logon. C2 Security Evaluation vs. Certification Setting up a C2-compliant System Abstract Microsoft® Windows NT® operating system provides a rich set of security features. However, the default out-of-the-box configuration is highly relaxed, especially on the Workstation product. This is because the operating system is sold as a shrink-wrapped product with an assumption that an average customer may not want to worry about a highly restrained but secure system on their desktop. This assumption has changed over the years as Windows NT gains popularity largely because of its security features. Microsoft is investigating a better secured default configuration for future releases. In the meantime, this white paper talks about various security issues with respect to configuring all Windows NT version 4.0 OS products for a highly secure computing environment. -
Professor Messer's
Professor Messer’s CompTIA 220-1002 Core 2 A+ Course Notes James “Professor” Messer http://www.ProfessorMesser.com Professor Messer’s CompTIA 220-1002 Core 2 A+ Course Notes Written by James “Professor” Messer Copyright © 2018 by Messer Studios, LLC http://www.ProfessorMesser.com All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without written permission from the publisher. First Edition: September 2018 Trademark Acknowledgments All product names and trademarks are the property of their respective owners, and are in no way associated or affiliated with Messer Studios LLC. “Professor Messer” is a registered trademark of Messer Studios LLC. “CompTIA” and “A+” are registered trademarks of CompTIA, Inc. Warning and Disclaimer This book is designed to provide information about the CompTIA 220-1002 A+ certification exam. However, there may be typographical and/or content errors. Therefore, this book should serve only as a general guide and not as the ultimate source of subject information. The author shall have no liability or responsibility to any person or entity regarding any loss or damage incurred, or alleged to have incurred, directly or indirectly, by the information contained in this book. Contents 1.0 - Operating Systems 1 1.1 - Operating Systems Overview 1 1.2 - An Overview of Windows 7 2 1.2 - An Overview of Windows 8 and 8.1 3 1.2 - An Overview of Windows 10 4 1.2 -
Getting Started Deciphering
Getting Started DECIPHERing Erik S. Wright May 19, 2021 Contents 1 About DECIPHER 1 2 Design Philosophy 2 2.1 Curators Protect the Originals . 2 2.2 Don't Reinvent the Wheel . 2 2.3 That Which is the Most Difficult, Make Fastest . 2 2.4 Stay Organized . 2 3 Functionality 3 4 Installation 5 4.1 Typical Installation (recommended) . 5 4.2 Manual Installation . 5 4.2.1 All platforms . 5 4.2.2 MacOSX........................................... 6 4.2.3 Linux ............................................. 6 4.2.4 Windows ........................................... 6 5 Example Workflow 6 6 Session Information 11 1 About DECIPHER DECIPHER is a software toolset that can be used for deciphering and managing biological sequences efficiently using the R statistical programming language. The program features tools falling into five categories: Sequence databases: import, maintain, view, and export a massive number of sequences. Sequence alignment: accurately align thousands of DNA, RNA, or amino acid sequences. Quickly find and align the syntenic regions of multiple genomes. Oligo design: test oligos in silico, or create new primer and probe sequences optimized for a variety of objectives. Manipulate sequences: trim low quality regions, correct frameshifts, reorient nucleotides, determine consensus, or digest with restriction enzymes. Analyze sequences: find chimeras, classify into a taxonomy of organisms or functions, detect repeats, predict secondary structure, create phylogenetic trees, and reconstruct ancestral states. 1 Gene finding: predict coding and non-coding genes in a genome, extract them from the genome, and export them to a file. DECIPHER is available under the terms of the GNU Public License version 3. 2 Design Philosophy 2.1 Curators Protect the Originals One of the core principles of DECIPHER is the idea of the non-destructive workflow. -
[MS-SAMR-Diff]: Security Account Manager (SAM) Remote Protocol (Client- To-Server)
[MS-SAMR-Diff]: Security Account Manager (SAM) Remote Protocol (Client- to-Server) Intellectual Property Rights Notice for Open Specifications Documentation . Technical Documentation. Microsoft publishes Open Specifications documentation for protocols, file formats, languages, standards as well as overviews of the interaction among each of these technologies. Copyrights. This documentation is covered by Microsoft copyrights. Regardless of any other terms that are contained in the terms of use for the Microsoft website that hosts this documentation, you may make copies of it in order to develop implementations of the technologies described in the Open Specifications and may distribute portions of it in your implementations using these technologies or your documentation as necessary to properly document the implementation. You may also distribute in your implementation, with or without modification, any schema, IDL's, or code samples that are included in the documentation. This permission also applies to any documents that are referenced in the Open Specifications. No Trade Secrets. Microsoft does not claim any trade secret rights in this documentation. Patents. Microsoft has patents that may cover your implementations of the technologies described in the Open Specifications. Neither this notice nor Microsoft's delivery of the documentation grants any licenses under those or any other Microsoft patents. However, a given Open Specification may be covered by Microsoft Open Specification Promise or the Community Promise. If you would prefer a written license, or if the technologies described in the Open Specifications are not covered by the Open Specifications Promise or Community Promise, as applicable, patent licenses are available by contacting [email protected]. Trademarks. -
Windows Server 2016 Security Guide
Windows Server Security Guide August 2017 © 2017 Microsoft Corporation. All rights reserved. The information in this document represents the current view of Microsoft on the content. MICROSOFT MAKES NO WARRANTIES, EXPRESS, IMPLIED, OR STATUTORY, AS TO THE INFORMATION ON THIS DOCUMENT Contents Windows Server 2016 Security Guide ............................................................. 3 Why is Windows Server 2016 security important? ............................................................................... 3 How does Windows Server 2016 help prevent and detect compromise? ........................................... 4 Additional resources ............................................................................................................................. 5 Build a secure foundation .............................................................................. 5 Stay current on Windows Server security updates ............................................................................... 5 Configure Windows Server security settings ........................................................................................ 6 The high-level process for obtaining and deploying the security baselines can be found in the Microsoft Security Compliance Toolkit 1.0. You can find out more about current Microsoft security guidance at Microsoft Security Guidance blog. .................................................................................... 7 Back up your information and systems ............................................................................................... -
ASOC Security Bulletin
Advanced Security Operations Center Telelink Business Services www.tbs.tech Monthly Security Bulletin August 2021 This security bulletin is powered by Telelink’s Advanced Security Operations Center The modern cybersecurity threat landscape is constantly evolving. New vulnerabilities and zero-day attacks are discovered every day. The old Why Advanced Security Operations vulnerabilities still exist. The tools to exploit these vulnerabilities are Center (ASOC) by Telelink? applying more complex techniques. But are getting easier to use. • Delivered as a service, which Mitigating modern cyber threats require solutions for continuous guarantees fast implementation, monitoring, correlation, and behavior analysis that are expensive and clear responsibility in the require significant amount of time to be implemented. Moreover, many Supplier and ability to cancel the organizations struggle to hire and retain the expensive security experts contract on a monthly basis. needed to operate those solutions and provide value by defending the • Built utilizing state of the art organizations. leading vendor’s solutions. The ASOC by Telelink allows organizations get visibility, control, and • Can be sized to fit small, recommendations on improving their security posture for a fixed and medium and large business predictable monthly fee. needs. • No investment in infrastructure, team, trainings or required technology. • Flexible packages and add-ons that allow pay what you need approach. • Provided at a fraction of the cost of operating your own SOC. LITE -
Active Directory for the Security Professional
Beyond the MCSE: Active Directory for the Security Professional Sean Metcalf Trimarc TrimarcSecurity.com Black Hat USA 2016 Table of Contents Overview ....................................................................................................................................................... 4 Differing Views of Active Directory ............................................................................................................... 5 Active Directory Components ....................................................................................................................... 6 Administration .......................................................................................................................................... 6 Forest ........................................................................................................................................................ 9 Domains .................................................................................................................................................. 10 Schema .................................................................................................................................................... 10 Trusts ....................................................................................................................................................... 11 Sites, Subnets, & Replication .................................................................................................................. 13 Organizational