Dame Sheila Patricia Violet Sherlock

Total Page：16

File Type：pdf, Size：1020Kb

Dame Sheila Patricia Violet Sherlock Dame Sheila was born in Ireland and educated at Folkestone Grammar School. When she graduated from Edinburgh University with honours in 1941 she was the Ettles Scholar of her year and went on to spend a year as clinical assistant to Sir James Learmonth in Edinburgh. She moved to London and worked at the Hammersmith Hospital before going to Yale University on a Rockefeller Fellowship. In 1948, at the age of thirty, she was appointed lecturer and honorary consultant physician specialising in hepatology at the Hammersmith Hospital and Post-graduate Medical School and three years later was elected FRCP, by far the youngest woman to be elected to the College. In 1959 she moved to the Royal Free Hospital and Medical School, retiring in 1983. Her department of hepatology was internationally famous as a centre for research and teaching. Sheila Sherlock was one of the founders of modern hepatology. She was exceptionally talented with a remarkable memory, strong intellect and the capacity to anticipate where the next advances in her discipline would occur. Her contributions to the study and clinical management of liver diseases were many and of fundamental importance. She pioneered the use of percutaneous liver biopsy, elucidated the mechanism of portal hypertension, and was one of the first to appreciate the importance of immunological mechanisms in the pathogenesis of cirrhosis and hepatitis. After retiral she moved to the Department of Surgery where she worked, wrote and maintained her extensive international connections. She wrote Diseases of the Liver and Biliary System which ran to eleven editions and has been translated into several languages. She was the first woman to be appointed Professor of Medicine in the UK and the first to be appointed Vice- President of the Royal College of Physicians. She was the recipient of numerous fellowships and honours and was appointed a DBE in 1978, elected an Honorary Fellow of the Royal Society of Edinburgh in 1989 and Fellow of the Royal Society in 2000. Reproduced by permission of the University of Edinburgh Graduates Association. First published in the University of Edinburgh Journal, June 2002. Dame Sheila Patricia Violet Sherlock MB, MD, FRCP, FRCPE, FRS; born 18 March 1918; elected HonFRSE 6 March 1989; died 30 December 2001..

Copy Link

Recommended publications

Births, Marriages, and Deaths
DEC. 31, 1955 MEDICAL NEWS MEDICALBRrsIJOURNAL. 1631 Lead Glazes.-For some years now the pottery industry British Journal of Ophthalmology.-The new issue (Vol. 19, has been forbidden to use any but leadless or "low- No. 12) is now available. The contents include: solubility" glazes, because of the risk of lead poisoning. EXPERIENCE IN CLINIcAL EXAMINATION OP CORNEAL SENsITiVrry. CORNEAL SENSITIVITY AND THE NASO-LACRIMAL REFLEX AFTER RETROBULBAR However, in some teaching establishments raw lead glazes or ANAES rHESIA. Jorn Boberg-Ans. glazes containing a high percentage of soluble lead are still UVEITIS. A CLINICAL AND STATISTICAL SURVEY. George Bennett. INVESTIGATION OF THE CARBONIC ANHYDRASE CONTENT OF THE CORNEA OF used. The Ministry of Education has now issued a memo- THE RABBIT. J. Gloster. randum to local education authorities and school governors HYALURONIDASE IN OCULAR TISSUES. I. SENSITIVE BIOLOGICAL ASSAY FOR SMALL CONCENTRATIONS OF HYALURONIDASE. CT. Mayer. (No. 517, dated November 9, 1955) with the object of INCLUSION BODIES IN TRACHOMA. A. J. Dark. restricting the use of raw lead glazes in such schools. The TETRACYCLINE IN TRACHOMA. L. P. Agarwal and S. R. K. Malik. APPL IANCES: SIMPLE PUPILLOMETER. A. Arnaud Reid. memorandum also includes a list of precautions to be ob- LARGE CONCAVE MIRROR FOR INDIRECT OPHTHALMOSCOPY. H. Neame. served when handling potentially dangerous glazes. Issued monthly; annual subscription £4 4s.; single copy Awards for Research on Ageing.-Candidates wishing to 8s. 6d.; obtainable from the Publishing Manager, B.M.A. House, enter for the 1955-6 Ciba Foundation Awards for research Tavistock Square, London, W.C.1.
[Show full text]
The Management of Acute Hepatic Failure SHEILA SHERLOCK SP PARBHOO
Postgraduate Medical Journal (July 1971) 47, 493-498. Postgrad Med J: first published as 10.1136/pgmj.47.549.493 on 1 July 1971. Downloaded from The management of acute hepatic failure SHEILA SHERLOCK S. P. PARBHOO Departments of Medicine and Surgery, Royal Free Hospital, London W.C.1 Summary TABLE 1. Royal Free Hospital fulminant hepatitis Acute fulminant hepatitis leads to complex bio- 1959-70 chemical and circulatory disturbances including coma. Number 83 These can be predicted to some extent by knowledge Viral hepatitis 63 of the functions of the normal liver cells. Ineffective Drugs 19 Halothane 6 haemostasis, coma, hypoglycaemia, electrolyte abnor- Amine oxidase inhibitor 9 malities, hypotension and renal circulatory failure are Anti-TB 3 particularly important. Paracetamol 1 Management should be governed by the abnor- Fatty liver pregnancy malities found in the individual patient. Fluid overload Survived 9 (12%Y) and sedation must be avoided. More complex methods Died 74 of temporary hepatic support such as exchange trans- fusion or perfusion of the isolated pig's liver should sonality. The patient may show episodes of anti- Protected by copyright. only be considered after simpler methods of correction social behaviour or character disturbance. Night- have been attempted for a reasonable period of time mares, headache and dizziness are other inaugural and found wanting. non-specific symptoms. Violent behaviour is common The prognosis of acute hepatocellular failure in children, who may also have fits. The acute reaching the stage of deep coma is very poor, the organic reaction with delirium and clouding of mortality being about 80-90 %.
[Show full text]
L-G-0000599961-0002364478.Pdf
SHERLOCK’S DISEASES OF THE LIVER AND BILIARY SYSTEM Companion Website This book has a companion website www.wiley.com/go/sherlock/liver with: • All 700 fi gures and captions in the book as Powerpoints for downloading Sherlock’s Diseases of the Liver and Biliary System EDITED BY JAMES S. DOOLEY Centre for Hepatology University College London Medical School and Royal Free Sheila Sherlock Liver Centre Royal Free Hospital London UK ANNA S. F. LOK Division of Gastroenterology University of Michigan Health System Ann Arbor USA ANDREW K. BURROUGHS Royal Free Sheila Sherlock Liver Centre Royal Free Hospital; University College London London UK E. JENNY HEATHCOTE Division of Gastroenterology University Health Network University of Toronto Toronto Ontario Canada 12TH EDITION A John Wiley & Sons, Ltd., Publication This edition fi rst published 2011, © 1963, 1968, 1975, 1981, 1985, 1989, 1993, 1997, 2002, 2011 by Blackwell Publishing Ltd Blackwell Publishing was acquired by John Wiley & Sons in February 2007. Blackwell’s publishing program has been merged with Wiley’s global Scientifi c, Technical and Medical business to form Wiley-Blackwell. First published 1955 Second edition 1958 Third edition 1963 Fourth edition 1968 Fifth edition 1975 Sixth edition 1981 Seventh edition 1985 Eighth edition 1989 Ninth edition 1993 Tenth edition 1997 Eleventh edition 2002 Registered offi ce: John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK Editorial offi ces: 9600 Garsington Road, Oxford, OX4 2DQ, UK The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK 111 River Street, Hoboken, NJ 07030-5774, USA For details of our global editorial offi ces, for customer services and for information about how to apply for permission to reuse the copyright material in this book please see our website at www.wiley.com/wiley-blackwell The right of the author to be identifi ed as the author of this work has been asserted in accordance with the Copyright, Designs and Patents Act 1988.
[Show full text]
MEDICALBJOURNAL Birthis, MARRIAGES, and DEATHS
1558 DEC. 28, 1957 MEDICAL NEWS MEDICALBJOURNAL aged sick, and £25.000 for grants to convalescent homes. Van Meter Prize.-The American Goiter Association Sir ARCHIBALD GRAY said the distribution committee had again offers the Van Meter Prize Award of $300 and two made a grant of £10,000 to the British Student Tuberculosis honourable mentions for the best essays on originial work Foundation. This Foundation had been started, he said, on problems related to the thyroid gland. Essays may cover entirely by university students, who since 1950 had collected either clinical or research investigations, should not exceed something like £35,000 to help students with pulmonary 3,000 words in length, and must be presented in English. tuberculosis. Up to the present, accommodation had been Duplicate typewritten copies, double spaced, should be sent in two centres outside London, to which it was difficult for to Dr. JOHN C. MCCLINTOCK, 149}, Washington Avenue, tutors from the various colleges to travel. Mottingham Albany, 10, New York, not later than February 1. Hall, in the grounds of Grove Park Hospital, Lewisham, Medical Auxiliaries.-Recognition was granted by the was now to be converted into a hostel, taking about 35 Board of Registration during 1956-7 to the Society of ambulant cases, and there would be two wards in Grove Audiology Technicians and the Institute of Technicians in Park Hospital for those who had to be hospitalized. The Venereology, it is stated in the Board's annual report. students would thus get much better accommodation, with During the year registers of orthoptists, operating theatre a resident warden, and be within easy reach of the various technicians, and dispensing opticians were published.
[Show full text]
Access to Electronic Thesis
Access to Electronic Thesis Author: Elizabeth Brewster Thesis title: An investigation of experiences of reading for mental health and well-being and their relation to models of bibliotherapy Qualification: PhD This electronic thesis is protected by the Copyright, Designs and Patents Act 1988. No reproduction is permitted without consent of the author. It is also protected by the Creative Commons Licence allowing Attributions-Non-commercial-No derivatives. This thesis was embargoed until 31 December 2013. If this electronic thesis has been edited by the author it will be indicated as such on the title page and in the text. An investigation of experiences of reading for mental health and well-being and their relation to models of bibliotherapy Elizabeth Brewster A study submitted in fulfilment of the requirements for the degree of Doctor of Philosophy at the University of Sheffield Information School September 2011 ii Abstract Bibliotherapy is the use of imaginative or self-help literature as an intervention for mental health problems. It aims to provide psycho-social support and treatment and is used with individuals or in a group. Bibliotherapy has come to prominence in the UK over the past decade. Bibliotherapy schemes mainly operate in partnership between the public library and the NHS. Previous research on bibliotherapy has focused on the quantitative effectiveness of the intervention or anecdotal report of individual successes. Evaluation of current schemes and qualitative investigation of the views of those experiencing bibliotherapy have been neglected in previous research, providing the rationale for this thesis. The thesis argues that because there have been shortcomings in previous research, there are differences in the understanding between those managing bibliotherapy schemes, and those using the schemes.
[Show full text]
Journal of Clinical Pathology J Clin Pathol: First Published As on 1 January 1980
Journal of Clinical Pathology J Clin Pathol: first published as on 1 January 1980. Downloaded from British Medical Association, Tavistock Square, London WCIH 9JR Contents Vol 33, No 1, January 1980 Recommendation for reference method for Use of the API-ZYM system in rapid determination by centrifugation of packed cell identification of a and non-haemolytic volume of blood streptococci INTERNATIONAL COMMITTEE FOR SHEENA A WAITKINS, LYN C BALL, AND STANDARDIZATION IN HAEMATOLOGY EXPERT CHERRY AM FRASER pages 53-57 PANEL ON BLOOD CELL SIZING pages 1-2 Significance of bacterial and white cell counts Sex-related differences in the haematological in midstream urines effects of excessive alcohol consumption PJ LITTLE, BARBARA A PEDDIE, AND DM CHALMERS, I CHANARIN, S MACDERMOTT, ADRIENNE R SINCOCK pages 58-60 AND AJ LEVI pages 3-7 Multiple selective media for the isolation of anaerobic bacteria from clinical specimens Long-term storage of blood in liquid nitrogen, MWD WREN pages 61-65 and the response of the recovered red cells to haemagglutination by viruses Bacteriological examination of pus from FG RODGERS pages 8-10 abscesses of the central nervous system JOHN DE LOUVOIS pages 66-71 Adult pulmonary cytomegalic inclusion disease: report of a case An assessment of the Mi-Mark endometrial JD BROWNING, IAR MORE, AND JF BOYD sampling technique pages 11-18 JULIE CROW, H GORDON, AND ELIZABETH HUDSON pages 72-80 http://jcp.bmj.com/ Improved economics of HBsAg screening with Haemangioleiomyomatous tumour of the lung commercial radioimmunoassay reagents AJAIB S SOORAE AND HOSHANG BHARUCHA R HOPKINS, SYLVIA ROSS, T JORDAN, AND pages 81-85 AD WATT pages 19-23 lonised calcium in pathological human bile Susceptibility to rubella in a pregnant D JUNE SUTOR, LYNETTE I WILKIE, AND population after the introduction of MJ JACKSON pages 86-88 on September 26, 2021 by guest.
[Show full text]
E . J E N N Y H E a T H C O T E Dr. E.J.L. (Jenny) Heathcote
E . J E N N Y H E A T H C O T E Dr. E.J.L. (Jenny) Heathcote was born in the UK and graduated from the Royal Free Hospital School of Medicine, London, UK in 1968. She was introduced to the field of liver disease immediately as her first position as a resident was with the late Dame Professor Sheila Sherlock – the most famous hepatologist of her time. Following completion of her internal medicine training, Jenny returned to the Sheila Sherlock “empire” where she spent 4 years doing research on the transmission of Hepatitis B - she was awarded her MD thesis in 1976. Jenny emigrated to the USA and later accepted a staff position in Canada at the University of Toronto where she has remained for 33 years. From scratch she built a clinical program in Hepatology with a particular focus of viral hepatitis (B and later C) and autoimmune liver disease. She has been a Professor at the University of Toronto since 1995, winning the Department of Medicine Clinician Teacher Award in the same year. She had been awarded the May Cohen Award by the Canadian Medical Association for her mentoring of trainees in 2003. In this same year she initiated the National Canadian Research Training Program in Hepatitis C (CIHR funded) where she was the PI until the program was refunded in 2009. She is a recipient of the Queen’s Jubilee Gold Medal for her service to hepatology and received the Canadian Liver Foundation Gold Medal in 2004. In that year, she also received the Canadian Liver Foundation Lifetime Achievement Award.
[Show full text]
Intestinal Absorption Christie, DA; Tansey, EM
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Queen Mary Research Online Intestinal absorption Christie, DA; Tansey, EM For additional information about this publication click this link. http://qmro.qmul.ac.uk/jspui/handle/123456789/2800 Information about this research object was correct at the time of download; we occasionally make corrections to records, please therefore check the published record when citing. For more information contact [email protected] Wellcome Witnesses to Twentieth Century Medicine INTESTINAL ABSORPTION A Witness Seminar held at the Wellcome Institute for the History of Medicine, London, on 9 February 1999 Witness Seminar Transcript edited by D A Christie and E M Tansey Introduction by Sir Christopher Booth Volume 8 – September 2000 ©The Trustee of the Wellcome Trust, London, 2000 First published by the Wellcome Trust, 2000 The Wellcome Trust is a registered charity, no. 210183. ISBN 978 184129 017 1 All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/ Please cite as: Christie D A, Tansey E M. (eds) (2000) Intestinal Absorption. Wellcome Witnesses to Twentieth Century Medicine, vol. 8. London: Wellcome Trust. Key Front cover photographs, L to R from the top: Dr Derek Holdsworth Dr Peter Hanson, Dr Richard Boyd Dr Peter Williams, Professor Oliver Wrong Professor Ramsey Bronk, Professor Michael Gardner Lord Turnberg (chair), Professor Timothy Peters Dr Richard Boyd, Professor Ramsey Bronk Dr Sheila Callender (1914–2004), Professor Hermon Dowling Dr Roy Levin, Sir Christopher Booth Back cover photographs, L to R from the top: Professor Hermon Dowling, Sir Christopher Booth Professor Michael Gardner, Dr Peter Hanson, Dr Richard Boyd, Professor Ramsey Bronk Professor John Walker-Smith, Dr George Misiewicz Dr Michael Hellier Professor Roy Pounder Dr George Misiewicz Professor Oliver Wrong CONTENTS Introduction Sir Christopher Booth i Witness Seminars: Meetings and publications ii Transcript 1 List of plates Figure 1.
[Show full text]
2020 Dr. Philipp Schwabl Host Institute
Sheila Sherlock Post-graduate Fellowship - 2020 Dr. Philipp Schwabl Host Institute: University College London Biography: Philipp Schwabl was born 1988 in Vienna and is working at the Department of Gastroenterology and Hepatology (Head: Michael Trauner) at the Medical University of Vienna for over 10 years. Mentored by Thomas Reiberger, the focus of his work lies in the translational research of liver cirrhosis and portal hypertension. As a physician/scientist Philipp Schwabl has long lasting experience in both, treatment of cirrhotic patients and in-vivo experiments with respective liver disease models. This allows him to investigate novel treatment options for portal hypertension from bench to bedside. In his past works, within the Reiberger group, Philipp studied the hemodynamic effects and the underlying pathophysiological mechanisms of drugs like nebivolol, sorafenib, pioglitazone, PX206065 (non-steroidal FXR agonist) or riociguat (soluble guanylyl cyclase stimulator) in different portal hypertensive models. He also explored the clinical impact of hepatitis C clearance on portal hypertension, and investigated elastography and biomarkers to assess cirrhosis, portal hypertension and respective clinical outcomes. Philipp is also active as a teacher at the Medical University of Vienna and has been the president of the Young Scientist Association at his university. He has acquired funding for several peer-reviewed projects and received national and international awards for his scientific contributions. Research Project: Research Project: Targeting stellate cell contraction to reduce liver tissue tension and treat portal hypertension Hepatic stellate cells (HSC) are pericytes lining the liver sinusoids in the space of Disse. In case of liver damage HSC become contractile. Thus, HSC affect tissue tension and sinusoidal flow, which subsequently promotes inflammation, fibrogenesis and portal hypertension.
[Show full text]
2019 Unclaimed Property Report
NOTICE TO OWNERS OF ABANDONED PROPERTY: 2019 UNCLAIMED PROPERTY REPORT State Treasurer John Murante 402-471-8497 | 877-572-9688 treasurer.nebraska.gov Unclaimed Property Division 809 P Street Lincoln, NE 68508 Dear Nebraskans, KUHLMANN ORTHODONTICS STEINSLAND VICKI A WITT TOM W KRAMER TODD WINTERS CORY J HART KENNETH R MOORE DEBRA S SWANSON MATHEW CLAIM TO STATE OF NEBRASKA FOR UNCLAIMED PROPERTY Reminder: Information concerning the GAYLE Y PERSHING STEMMERMAN WOLFE BRIAN LOWE JACK YOUNG PATRICK R HENDRICKSON MOORE KEVIN SZENASI CYLVIA KUNSELMAN ADA E PAINE DONNA CATHERNE COLIN E F MR. Thank you for your interest in the 2019 Property ID Number(s) (if known): How did you become aware of this property? WOODWARD MCCASLAND TAYLORHERDT LIZ “Claimant” means person claiming property. amount or description of the property and LARA JOSE JR PALACIOS AUCIN STORMS DAKOTA R DANNY VIRGILENE HENDRICKSON MULHERN LINDA J THOMAS BURDETTE Unclaimed Property Newspaper Publication BOX BUTTE Unclaimed Property Report. Unclaimed “Owner” means name as listed with the State Treasurer. LE VU A WILMER DAVID STORY LINDA WURDEMAN SARAH N MUNGER TIMOTHY TOMS AUTO & CYCLE Nebraska State Fair the name and address of the holder may PARR MADELINE TIFFANY ADAMS MICHAEL HENZLER DEBRA J property can come in many different Husker Harvest Days LEFFLER ROBERT STRATEGIC PIONEER BANNER MUNRO ALLEN W REPAIR Claimant’s Name and Present Address: Claimant is: LEMIRAND PATTNO TOM J STREFF BRIAN WYMORE ERMA M BAKKEHAUG HENZLER RONALD L MURPHY SHIRLEY M TOOLEY MICHAEL J Other Outreach
[Show full text]
Royal Free Sheila Sherlock Virtual Hepatology Postgraduate Course 2021
Royal Free Sheila Sherlock Virtual Hepatology Postgraduate Course 2021 Wed 24th March – Fri 26th March 2021 Day 1: Hepatology in the clinic 09.00-09.15 Opening welcome (Prof Massimo Pinzani) & Course introduction (Dr Nekisa Zakeri) Each talk 20mins (+ 5mins for Q&As) Session 1: Liver disease & Lifestyle. Chair: Prof Massimo Pinzani. 09.15-09.40 Alcohol-related liver disease (Prof Kevin Moore) 09.40-10.05 Non-alcoholic fatty liver disease (Dr Penny Manousou) 10.05-10.10 Discussion/interval 10.10-10.35 NAFLD: risk stratification & streamlining referrals (Prof EmmanueL Tsochatzis) 10.35-10.55 Coffee Break Session 2: Viral hepatitis & hereditary liver diseases. Chair: Dr Doug Macdonald. 10.55-11.20 Hepatitis B (Dr Doug Macdonald) 11.20-11.45 Hepatitis C (Prof WiLLiam Rosenberg) 11.45-11.50 Discussion/interval 11.50-12.15 Hyperferritinaemia & hereditary haemochromatosis (Dr James Dooley) 12.15-13.00 Lunch Break Section 3: Radiology & liver lesions. Chair: Dr AiLeen MarshalL. 13.00-13.25 Radiology cases (Dr Dominic Yu) 13.25-13.50 Hepatocellular carcinoma (Dr AiLeen MarshalL) 13.50-13.55 Discussion/interval 13.55-14.20 Immunotherapy-related liver complications (Dr Doug Macdonald) 14.20-14.40 Coffee Break Session 4: Autoimmune liver diseases. Chair: Prof Doug Thorburn. 14.40-15.05 Primary Biliary Cholangitis (Prof Doug Thorburn) 15.05-15.30 Autoimmune hepatitis (Dr Jon Potts) 15.30-15.40 Discussion/interval Session 5: Pancreato-Biliary & hereditary liver diseases. Chair: Dr Jon Potts. 15.40-16.05 Primary Sclerosing Cholangitis (Prof Steve Pereira) 16.05-16.30 Wilson’s disease (Dr James DooLey) 16.30 Closing remarks Day 2: Hepatology on the acute take 08.50-09.00 Opening welcome (Prof Massimo Pinzani) Each talk 20mins (+ 5mins for Q&As) Session 1: Cirrhosis & its complications.
[Show full text]
Patients with Liver Cirrhosis Suffer from Primary Haemostatic Defects? Fact Or fiction?
Review Patients with liver cirrhosis suffer from primary haemostatic defects? Fact or fiction? ⇑ F. Violi1, , S. Basili1, V. Raparelli1, P. Chowdary2, A. Gatt2, A.K. Burroughs3 1Divisione di I Clinica Medica, Sapienza-University of Rome, Rome, Italy; 2Haemophilia Centre & Thrombosis Unit, Royal Free Hospital Hampstead NHS Trust, London, UK; 3The Royal Free Sheila Sherlock Liver Centre and University Department of Surgery UCL, London, UK Patients with cirrhosis can have abnormalities in laboratory pro-coagulant and anti-coagulant factors, low-grade coagulation tests reflecting changes in primary haemostasis, including bleed- activation, and hyperfibrinolysis. Patients with cirrhosis can have ing time, platelet function tests, markers of platelet activation, abnormalities in laboratory tests reflecting changes in primary and platelet count. Such changes have been considered particu- haemostasis, including bleeding time (BT), platelet aggregation larly relevant in the bleeding complications that occur in cirrhosis. tests, and platelet count. Laboratory tests of platelet function con- However, several studies have shown that routine diagnostic sistently show that primary haemostasis is impaired in cirrhosis tests, such as platelet count, bleeding time, PFA-100, thrombo- as a consequence of reduced platelet function and/or low platelet elastography are not clinically useful to stratify bleeding risk in count [5]. Such changes have been considered particularly rele- patients with cirrhosis. Moreover, treatments used to increase vant in the bleeding complications that occur in cirrhosis, so that platelet count or to modulate platelet function could potentially the clinical effect of drugs that improve platelet function [6–9],or do harm. Consequently the optimal management of bleeding number of platelets [10] has been investigated in cirrhosis.
[Show full text]