Katja Guenther, MD
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Neuropathology of Dementia in Patients with Parkinson's Disease: a Systematic Review of Autopsy Studies
Neurodegeneration J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp-2019-321111 on 23 August 2019. Downloaded from REVIEW Neuropathology of dementia in patients with Parkinson’s disease: a systematic review of autopsy studies Callum Smith ,1 Naveed Malek,2 Katherine Grosset,1 Breda Cullen ,3 Steve Gentleman,4 Donald G Grosset1 ► Additional material is ABSTRact have other causes of cognitive impairment and published online only. To view Background Dementia is a common, debilitating dementia, such as comorbid Alzheimer’s disease please visit the journal online (http:// dx. doi. org/ 10. 1136/ feature of late Parkinson’s disease (PD). PD dementia (AD) or cerebrovascular disease. These pathologies jnnp- 2019- 321111). (PDD) is associated with α-synuclein propagation, but may be difficult to identify in vivo, as the clinical coexistent Alzheimer’s disease (AD) pathology may features often overlap with those of PDD, and there 1 Department of Neurology, coexist. Other pathologies (cerebrovascular, transactive are no definitive biomarkers. The differentiation Institute of Neurosciences, response DNA-binding protein 43 (TDP-43)) may of dementia type is an important consideration in Queen Elizabeth University Hospital, Glasgow, UK also influence cognition.W e aimed to describe the clinical research, as treatments under development 2Department of Neurology, neuropathology underlying dementia in PD. are specifically targeted against abnormal accumu- Ipswich Hospital NHS Trust, Methods Systematic review of autopsy studies lation of α-synuclein, which is the pathological Ipswich, UK 3 3 published in English involving PD cases with dementia. hallmark of PDD and DLB, or tau or amyloid-β, Institute of Health and 4 5 Wellbeing, College of Medical, Comparison groups included PD without dementia, AD, which underlie AD. -
Approved by Supervisi G Committee
Copyright by Jane Katherine Arney 2011 The Thesis Committee for Jane Katherine Arney Certifies that this is the approved version of the following thesis: Expecting Epiphany: Performative Ritual and Roman Cultural Space APPROVED BY SUPERVISIG COMMITTEE: Supervisor: John R. Clarke Penelope J. E. Davies Expecting Epiphany: Performative Ritual and Roman Cultural Space by Jane Katherine Arney, B.A. Thesis Presented to the Faculty of the Graduate School of The University of Texas at Austin in Partial Fulfillment of the Requirements for the Degree of Master of Arts The University of Texas at Austin May 2011 Dedication This thesis is dedicated to Professor Kimberly Davis at Miracosta College, who helped me believe that I could do it. Acknowledgements The idea for this project began in Professor John Clarke’s “Seeing Gods” graduate seminar, in which we explored various aspects of epiphany. Dr. Clarke pointed out that there was fertile ground for this topic in Pompeii and guided me to the Twelve Gods mural. He has also pushed me out of my comfort zone and challenged me to explore areas of theory. I am most grateful for his generosity and his encouragement. I would also like to thank Professor Penelope Davies, whose interest, prodding and comments helped me to better understand and, I hope, improve my writing style. I feel extremely fortunate to have had the opportunity to work with these exemplary scholars whose works are of substantial importance to the field of Roman art history. May 6, 2011 v Abstract Expecting Epiphany: Performative Ritual and Roman Cultural Space Jane Katherine Arney, M.A The University of Texas at Austin, 2011 Supervisor: John R. -
Internet Resources for Neurosurgeons and Neuropathologists S Thomson, N Phillips
154 J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.74.2.154 on 1 February 2003. Downloaded from REVIEW Internet resources for neurosurgeons and neuropathologists S Thomson, N Phillips ............................................................................................................................. J Neurol Neurosurg Psychiatry 2003;74:154–157 Neurosurgical and neuropathological resources on the Neurosurgery://On-call has an “image bank” internet are rapidly developing. Some excellent clinical, section, which has an excellent downloadable collection of radiographs. There are also some patient information, professional, academic, and photographic images. This is a rapidly developing teaching web sites are available. This review database, easy to search, and likely to have images summarises the most useful online sites for relevant to most neurosurgical and neuropatho- logical conditions. neurosurgeons and neuropathologists in the United Neuroanatomy and Neuropathology on the Kingdom and beyond. More general internet resources Internet provides a very comprehensive collection of pathological images within the online neu- have been covered in the first article in this series. ropathology atlas. The neuroanatomy structures .......................................................................... subsection shows the locations of anatomical structures within normal pathological specimens. ver the past 10 years the internet has The functional neuroanatomy tables are also expanded rapidly. While potential ben- highly -
A Guide to Studying Neuroscience & Behavior
A GUIDE TO STUDYING NEUROSCIENCE & BEHAVIOR ABROAD It is no secret that the United States boasts some of the finest behavioral neuroscience programs in the world. Why bother going abroad then? How about exploring a new city, working with peers from around the world, and coming to gain a fuller appreciation of how the principles of biology transcend culture by immersing yourself in an entirely new social environment? Studying neuroscience and behavior abroad will take you far beyond the classroom, encompassing a much broader range of lessons by teaching you daily through living in a different culture. LOCATIONS There are a large amount of universities across the world that boasts respectable medical and scientific research departments. These are all highly prestigious institutions with track records, which boast multiple Nobel laureates and a thick resume of cutting edge scientific achievement. There are Universities all over the world, which offer an intriguing blend of scientific study with enriching cultural immersion. It is important to keep in mind that when studying neuroscience and behavior abroad, especially if only for one semester, that location can often prove more rewarding than the prestige of any academic institution. If you want to study abroad in a developing country in South America or Southeast Asia for example, do not let the lack of internationally acclaimed educational institutions deter you. You will learn much more from daily life in these places than you ever could in a classroom. COURSES & PROGRAMS What neuroscience and behavior courses you take abroad will depend heavily on your area of concentration within the broad field of neuroscience and behavioral research, as well as available courses at your host university or program. -
An Event-Related Brain Potential Study on Syntax and Semantics
UNIVERSIDAD COMPLUTENSE DE MADRID FACULTAD DE PSICOLOGÍA TESIS DOCTORAL The influence of facial information on language comprehension: an event-related brain potential study on syntax and semantics La influencia de la información facial en la comprensión del lenguaje: estudio con potenciales cerebrales evento-relacionados sobre sintaxis y semántica MEMORIA PARA OPTAR AL GRADO DE DOCTOR PRESENTADA POR David Hernández Gutiérrez Directores Manuel Martín-Loeches Garrido Francisco Muñoz Muñoz Madrid © David Hernández Gutiérrez, 2019 FACULTAD DE PSICOLOGÍA Dept. Psicobiología y Metodología en Ciencias del Comportamiento The influence of facial information on language comprehension: an event-related brain potential study on syntax and semantics La influencia de la información facial en la comprensión del lenguaje: estudio con potenciales cerebrales evento-relacionados sobre sintaxis y semántica Directores: Prof. Dr. Manuel Martín-Loeches Garrido Prof. Dr. Francisco Muñoz Muñoz David Hernández Gutiérrez TESIS DOCTORAL Madrid, 2019 DECLARACIÓN DE AUTORÍA Y ORIGINALIDAD DE LA TESIS PRESENTADA PARA OBTENER EL TÍTULO DE DOCTOR D./Dña.________________________________________________________________, estudiante en el Programa de Doctorado _____________________________________, de la Facultad de _____________________________ de la Universidad Complutense de Madrid, como autor/a de la tesis presentada para la obtención del título de Doctor y titulada: y dirigida por: DECLARO QUE: La tesis es una obra original que no infringe los derechos de propiedad intelectual ni los derechos de propiedad industrial u otros, de acuerdo con el ordenamiento jurídico vigente, en particular, la Ley de Propiedad Intelectual (R.D. legislativo 1/1996, de 12 de abril, por el que se aprueba el texto refundido de la Ley de Propiedad Intelectual, modificado por la Ley 2/2019, de 1 de marzo, regularizando, aclarando y armonizando las disposiciones legales vigentes sobre la materia), en particular, las disposiciones referidas al derecho de cita. -
Neuromuscular Medicine Core Competencies Outline
The American Board of Psychiatry and Neurology Neuromuscular Medicine Core Competencies Outline I. Neuromuscular Patient Care Core Competencies A. GENERAL: Neuromuscular Medicine Specialists shall demonstrate the following abilities: 1. To perform and document relevant history and examination of culturally diverse patient to include as appropriate: a. Chief complaint b. History of present illness c. Past medical history d. Developmental history (especially for children) e. Comprehensive review of both neurologic and general systems f. Biological family history g. Sociocultural history h. Neurological examination and a germane general examination as appropriate to the present illness 2. Delineate appropriate differential diagnoses 3. Formulate, assess and recommend effective management B. FOR NEUROMUSCULAR MEDICINE: Based on comprehensive neurological assessments, Neuromuscular Specialists shall demonstrate the following abilities: 1. To determine: a. If a patient’s symptoms are the result of a disease affecting the central and/or peripheral nervous system or are of another origin (e.g., of a systemic, psychiatric, or psychogenic illness) by performing appropriate neuromuscular evaluation b. An initial diagnostic formulation with differential diagnosis c. Appropriate diagnostic modalities to include laboratory blood, urine, and cerebrospinal fluid analyses, electrodiagnostic, imaging, genetic, and pathologic investigations to evaluate and manage such patients d. Management plan 2. To develop and maintain the technical skills to: a. Perform -
P:\Autism Cases\Dwyer 03-1202V\Opinion Segments NEW
IN THE UNITED STATES COURT OF FEDERAL CLAIMS OFFICE OF THE SPECIAL MASTERS No. 03-1202V Filed: March 12, 2010 ******************************************************* TIMOTHY and MARIA DWYER, parents of * COLIN R. DWYER, a minor, * Omnibus Autism Proceeding; * Theory 2 Test Case; Petitioners, * Thimerosal-Containing Vaccines; * Ethylmercury; Causation; v. * “Clearly Regressive” Autism; * Oxidative Stress; Sulfur SECRETARY OF THE DEPARTMENT OF * Metabolism Disruption; HEALTH AND HUMAN SERVICES, * Excitotoxicity; Expert * Qualifications; Weight of the Respondent. * Evidence * ******************************************************* DECISION1 James Collins Ferrell, Esq., Houston, TX; Thomas B. Powers, Esq. and Michael L. Williams, Esq., Portland, OR; for petitioners. Lynn Elizabeth Ricciardella, Esq. and Voris Johnson, Esq., U.S. Department of Justice, Washington, DC, for respondent. VOWELL, Special Master: On May 14, 2003, Timothy and Maria Dwyer [“petitioners”] filed a “short form” petition for compensation under the National Vaccine Injury Compensation Program, 42 U.S.C. § 300aa-10, et seq.2 [the “Vaccine Act” or “Program”], on behalf of their minor 1 Vaccine Rule 18(b) provides the parties 14 days to request redaction of any material “(i) which is trade secret or commercial or financial information which is privileged and confidential, or (ii) which are medical files and similar files, the disclosure of which would constitute a clearly unwarranted invasion of privacy.” 42 U.S.C § 300aa12(d)(4)(B). Both parties have waived their right to request such redaction. See Petitioners’ Notice to Waive the 14-Day Waiting Period, filed February 1, 2010; Respondent’s Consent to Disclosure, filed January 13, 2010. Accordingly, this decision will be publically available upon filing. 2 National Childhood Vaccine Injury Act of 1986, Pub. -
Stanford University Neuroradiology Fellowship
STANFORD UNIVERSITY NEURORADIOLOGY FELLOWSHIP The neuroradiology fellowship at Stanford University Medical Center is designed to be a well-balanced academic training program that encompasses all of the basic and advanced clinical and research areas of both adult and pediatric neuroradiology. The overall aims of this fellowship are two-fold: to produce neuroradiologists with the highest level of clinical expertise, and to produce the future leaders in academic neuroradiology. The goal of this fellowship program is for Neuroradiology fellows to develop knowledge, skills and attitudes necessary to properly evaluate, diagnose and manage patients with neurological, ENT and neurosurgical diseases. Therefore, this fellowship requires participation in clinical, research, and educational aspects of neuroradiology. Neuroradiology fellows will be exposed to all imaging modalities used to evaluate neurologic disease, including CT, MR, myelography, angiography, and imaging guided biopsies, during the course of the fellowship. Interventional neuroradiologic procedures are also performed at state-of-the-art levels at Stanford, and neuroradiology fellows will actively participate in these procedures. Goal of the Neuroradiology Fellowship Program Core Competencies Fellows should achieve the Interpersonal System following objectives: and -Based Patient Medical Practice-Based Communicati Professional Learni Care Knowledge Learning on Skills ism ng 1. Acquire specific knowledge about the physical principles of imaging modalities (CT,MR,ultrasound and digital subtraction angiography). X X 2. Identify the practical uses of CT, MR, ultrasound and digital subtraction angiography in the evaluation of neurologiocal, ENT and neurosurgical diseases. X X X 3. Develop thorough knowledge of the physical and physiological properties of contrast agents used in CT, MR, and angiography; including contraindications and management of potential complications. -
Neuropathology Review.Pdf
Neuropathology Review Richard A. Prayson, MD Humana Press Contents NEUROPATHOLOGY REVIEW 2 Contents Contents NEUROPATHOLOGY REVIEW By RICHARD A. PRAYSON, MD Department of Anatomic Pathology Cleveland Clinic Foundation, Cleveland, OH HUMANA PRESS TOTOWA, NEW JERSEY 4 Contents © 2001 Humana Press Inc. 999 Riverview Drive, Suite 208 Totowa, New Jersey 07512 For additional copies, pricing for bulk purchases, and/or information about other Humana titles, contact Humana at the above address or at any of the following numbers: Tel.: 973-256-1699; Fax: 973-256-8341; E-mail:[email protected]; Website: http://humanapress.com All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher. Due diligence has been taken by the publishers, editors, and authors of this book to assure the accuracy of the information published and to describe generally accepted practices. The contributors herein have carefully checked to ensure that the drug selections and dosages set forth in this text are accurate and in accord with the standards accepted at the time of publication. Notwithstanding, as new research, changes in government regulations, and knowledge from clinical experience relating to drug therapy and drug reactions constantly occurs, the reader is advised to check the product information provided by the manufacturer of each drug for any change in dosages or for additional warnings and contraindications. This is of utmost importance when the recommended drug herein is a new or infrequently used drug. It is the responsibility of the treating physician to determine dosages and treatment strategies for individual patients. -
Neuropathology and Which Upregulates P27
296A ANNUAL MEETING ABSTRACTS 1357 p27, Cks1, Skp2 and PTEN Expression in Hepatocellular Design: The WA Department of Health (DOH) disseminated information about the Carcinoma program to healthcare providers throughout the state. Enrollment was prompted V Zolota, V Tzelepi, A Liava, N Pagoni, T Petsas, C Karatza, CD Scopa, AC Tsamandas. by healthcare providers contacting local or state DOH, the National Prion Disease University of Patras School of Medicine, Patras, Greece. Pathology Surveillance Center (NPDPSC), or the Univ of WA (UW) to report a case Background: p27Kip1 is a cell-cycle inhibitory protein and its downregulation is mediated of suspected prion disease. No case was declined and all costs, including transportation by its specific ubiqitin subunits Cks1 and Skp2. PTEN is a tumor suppressor gene of the deceased, were covered. Autopsies were performed by UW Neuropathology and which upregulates p27. This study investigates p27, Cks1, Skp2 and PTEN expression brains were evaluated at this site and the NPDPSC. in hepatocellular carcinoma (HCC). Results: During the first 30 months of surveillance, 30 cases of suspected prion disease Design: Formalin-fixed, paraffin-embedded 4µm sections, obtained from 67 HCC were referred. Eighteen had prion disease classified as CJD. One case was familial while hepatectomy specimens with matched non-neoplastic liver, were subjected to the remainder had sporadic (s) CJD of the following subtypes: eight M/M isoform 1, immunohistochemistry using monoclonal and polyclonal antibodies for p27, Cks1, two M/M isoforms 1-2, two M/V isoforms 1-2, two M/V isoform 2, one V/V isoforms Skp2 and PTEN. Nuclear staining was considered as positive. -
Value of MR in Definition of the Neuropathology of Cerebral Palsy in Vivo
Commentary _____________________________________________________________ Value of MR in Definition of the Neuropathology of Cerebral Palsy in Vivo Joseph J. Volpe1 Cerebral palsy refers to a clinical syndrome of Selective Neuronal Necrosis nonprogressive motor deficits (usually spastic Selective neuronal necrosis, a common expres weakness, uncommonly choreoathetosis, rarely sion of injury secondary to hypoxic-ischemic in ataxia) of central origin with onset from early sult in the term infant, is characterized by neu infancy. In this issue of the Journal, Truwit et al ronal destruction in a typical distribution (see ref. describe the MR findings in 40 patients with the 2 for review). Cerebral cortical neurons, particu clinical diagnosis of cerebral palsy (1). The pur larly those of the CA 1 region of hippocampus poses of their retrospective study were to define (Sommer's sector), are especially vulnerable. (In the anatomic substrates of cerebral palsy in the the premature infant, neuronal injury occurs prin living patient and, from the definitions of the cipally in inferior olivary nuclei, ventral pons, and topography of the neuropathology and the analy subiculum of hippocampus, although periventric sis of clinical data, to suggest etiology and timing ular white matter injury tends to be the predom of the brain injury. The authors place particular inant hypoxic-ischemic lesion in such infants.) emphasis on their conclusion that cerebral palsy The pathophysiology of the typical neuronal in is usually not related to perinatal factors. The jury of the term infant, ie, in hippocampus and work is relevant to the role of hypoxic-ischemic neocortex, is related predominantly to the re brain injury in the genesis of cerebral palsy, the gional distribution of excitatory synapses me means of diagnosis of hypoxic-ischemic brain diated by the excitotoxic amino acid glutamate injury in the neonatal period, the spectrum of the (see refs. -
Fellowship Faqs Subspecialty Field: Clinical Neurophysiology What
Fellowship FAQs Subspecialty field: Clinical Neurophysiology What accreditation is available for fellowships (ACGME, UCNS, other) in this subspecialty field? ACGME Is board certification available in this subspecialty? If so, through which agency (ABPN, UCNS, other)? Yes, ABPN Does completion of this fellowship typically expand the scope of the subspecialist’s hospital credentials (added credentials for performing procedures, interpreting studies, etc)? In most cases, under current guidelines, these fellowships do not expand one’s ability to do procedures in most hospitals. Currently any board certified neurologist may perform these procedures. However, many hospitals are looking for candidates with additional training in these areas. In addition, some neuromuscular medicine specialists acquire added credentials to perform and interpret muscle and nerve biopsies. Yes, ability to perform and/or interpret clinical neurophysiological studies, including EMG, Nerve conduction studies, Evoked Potentials, EEG, video-EEG, Intraoperative monitoring, and sleep studies Is completion of a fellowship typically necessary in order to achieve a subspecialty-focused practice in an academic practice or a large neurology group practice? Whereas non-fellowship trained neurologists with an interest in neuromuscular medicine may see a similar patient population and perform EMG/NCS, it has become customary for neurologists seeking to do so within an academic medical center or sizeable group practice of neurologists to be fellowship trained. This is also true