DOCSLIB.ORG

Babak Larian 9401 Wilshire Blvd, Suite 650 TEL (310) 461 - 0300 MD, FACS Beverly Hills, CA 90212 [email protected]

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Babak Larian 9401 Wilshire Blvd, Suite 650 TEL (310) 461 - 0300 MD, FACS Beverly Hills, CA 90212 Dr@Larianmd.Com Babak Larian 9401 Wilshire Blvd, Suite 650 TEL (310) 461 - 0300 MD, FACS Beverly Hills, CA 90212 [email protected] ACADEMIC & PROFESSIONAL EXPERIENCE • Cedars-Sinai Medical Center • David Geffen School of Medicine at UCLA Chief, Division of Otolaryngology Assistant Clinical Professor of Surgery Head & Neck Surgery Division of Head & Neck Surgery Department of Surgery 2012-Present • Director of Center for Advanced Parathyroid Surgery • Cedars-Sinai Medical Center C0-Director of Otolaryngolgy Residency Program • Director of Center for Advanced Parotid Surgery Division of Otolaryngology 2019-Present • Cedars-Sinai Medical Center • HELPS International Medical Mission Director of Head and Neck Cancer Center Medical Director Center of Excellence Department of Surgery 2006-2012 • La Peer Surgery Center, Managing Partner 2006-2020 SURGICAL TRAINING AWARDS UCLA Medical Center • Alpha Omega Alpha Honor Medical Residency in Otolaryngology–Head & Neck Society 1993 Surgery • Phi Beta Kappa Golden Key Chairman - Gerald S. Berke, MD 1997 - 2002 National honor Society 1992 • University of California Regents’ UCLA Medical Center Scholarship 1992-96 Eighteen-month Rotating Internship in Surgery • Associated Medical Student Chairman - Carmack Holmes, MD Government Service Award 1996 – 1997 1996 • Merk Manual Award 1996 EDUCATION • Mac Kenzie Scholarship 1994-95 University of California, Irvine, School of • Dean’s Honor List 1988-92 Medicine Doctor of Medicine LICENSES Alpha Omega Alpha (AOA) • Board Certified Otolaryngology- University of California Regents’ Scholarship Head & Neck Surgery 1992 – 1996 2003-Present University of California, Irvine • Fellow of American College of Bachelor of Science, Biological Sciences Surgeons 2006- Magna Cum Laude Present 1988 – 1992 • Fellow of American Head & Neck Society 2007-Present PUBLICATIONS Epstein J, Song P, Ho A, Larian B, Asher A, Bensadoun RJ. Larian B, Balzer B, Talmi Y, Sagiv D, Santos J. Photobiomodulation therapy: management of Book Chapter: Benign Tumors mucosal necrosis of the oropharynx in previously Surgery of the Salivary Glands. Editor - Witt. pp treated head and neck cancer patients 216-226, Elsevier 2020. Support Care Cancer 2017 Apr;25(4):1031-1034. Hjelm N, Larian B, Azizzadeh B Massry G, Larian B. Novel Technique of Jones Tube Concurrent Parotidectomy with Symmetrical Facial Fixation for Refractory Tube Extrusion. Ophth plastic & Repositioning and Reconstruction: An Alogorithmic Reconstructive surgery 28(6) May 2012 Approach Facial Plast Surg & Aesth Med Jan-Feb Cutter CS, Adeshak KW, 2021;23(1):67-69 Babajanian M, Larian B. Book Chapter: Surgical Management of Thyroid Christopher LH, Slattery WH, Smith EJ, Larian B, Cancer. Azizzadeh B Thyroid Cancer. Editor - Braunstein. pp 207-241, Facial nerve management in patients with malignant Springer 2012. skull base tumors Lee K, Azizzadeh B, Larian B J Neurooncol. 2020 Dec;150(3):493-500. Book Chapter: Nasal Airway Obstruction Master Techniques in Rhinoplasty, Elsevier 2010 Azizzadeh B, Irvine LE, Yoo DB, Larian B, Massry GG, Peng GL Azizzadeh B, Buga GM, Berke GS, Larian B, Ignarro Single-incision sural nerve harvest: Technical LJ, Blackwell KE. considerations for cross-facial nerve grafting Inhibiton of Nitric Oxide Inhibitors Promote Laryngoscope 2019 Nov;129(11):2464-2466 Microvascular Thrombosis. Archives of Facial Plastic Surgery. 5(1):31-5, January 2003 Azizzadeh B, Irvine LE, Diels J, Slattery WH, Massry GG, Larian B, Riedler KL, Peng GL Azizzadeh B, Enayati P, Maghami E, Larian B, Modified Selective Neurectomy for the Treatment of Blackwell KE, Abemayor E, Calcaterra TC. Post-Facial Paralysis Synkinesis Long Term Outcome of Transhyoid Resection of Base Plast Reconstr Surg. 2019 May;143(5):1483-1496 of Tongue Squamous Cell Carcinoma. Archives of Otolaryngology-Head and Neck Surgery, Squibba JJ, Larian B 128(9):1067-70 September 2002. Oral squamous cell carcinoma: early detection and . improved 5-year survival in 102 patients Larian B, Alavi S, Roesler J, Namazie A, Blackwell K, Gen Dent. Nov-Dec 2018;66(6):e11-e16 Calcaterra TC, Wang MB. Clonality & Proliferative Activity of Single vs. Multiple Parathyroid Adenoma: Larian B. Parotidectomy for Benign Parotid Tumors. the Role of Hyperplasia. Head & Neck Surgery. Feb Oto Clin N America 2016. 2001; 23(2):134-39. Larian B, Azizzadeh B. Larian B, Namazie A, Agha N, Azizzadeh B, Blackwell Editors K, Wang MB. Publication Rate of Scientific Comprehensive Management of Parotid Disorders. Presentation at AAO. Otolaryngology- Head & Neck Otolaryngology Clinics of North America 2016. Surgery. 125(3):166-9, Septermber 2001. Maghami E, Bonyadlou S, Larian B, Borges A, Irvine L, Azizzadeh B, Larian B. Abemayor E, Lufkin R. MRI-Guided Fine Needle Loco-Regional Parotid Reconstruction. Aspiration Biopsies of Retropharyngeal Lesions. Oto Clin N America 2016. Laryngoscope, 111(12):2218-24, December 2001 Kochhar A, Larian B, Azizzadeh B Larian B, Wong B, Crumley RL, Moeinolmolki B, Facial Nerve and Parotid Gland Anatomy Muranaka E, Keates RH. Facial Trauma and Oto Clin N America 2016. Ocular/Orbital Injury. The Journal of Cranio- Maxillofacial Trauma. 5(4):15-24. 1999. Epstein J, Song P, Ho A, Larian B, Asher A, Bensadoun RJ. Givens KT, Lee D, Rothschiller J, Kitada S, Larian B, Management of radiation-induced Cortes A. Antiproliferative Drugs & Human mucosal necrosis with photobiomodulation therapy. Fibroblasts: Colorimetric vs. Cell Counting Assays. Support Care Cancer 2018;26:2493. Current Eye Research. 9(6):599-606. 1990. PRESENTATIONS Functional Nasal Disorders Advances in Facial Plastics & Reconstructive Surgery. September 2011 Primary Hyperparathyroidism Advanced Otolaryngology Course (CSMC) Director – Advances & Controversies in March 2021 Management of Head & Neck Cancer, Thyroid and Parathyroid Disorders, and Sinus Disease Bones, Moans and Groans & Treatment of Symposium (3 Day CME Course) Hyperparathyroidism Cedars-Sinai Medical Center. March 2011 Otolaryngology Update for The Primary Care (CSMC) January 2021 Parotid Reconstruction: Aesthetic & Functional Considerations. Advances in Multi-Specialty Hyperparathyroidism Aesthetic and Reconstructive Thomas Jefferson University Plastic Surgery Symposium. November 2010 Department of Otolaryngology April 2020 Functional Pre-operative Assessment for the Rhinoplasty Surgeon. Advances in Facial Diagnosis & Treatment of Hyperparathyroidism Plastics & Reconstructive Surgery. September 2009 Otolaryngology Update for The Primary Care (CSMC) March 2019 Director – Advances & Controversies in Management of Head & Neck Cancer, Thyroid and Advances In Diagnosis & Treatment of Parathyroid Disorders Symposium (2 Day CME Hyperparathyroidism Course) Cedars-Sinai Medical Center. Otolaryngology Update March 2009 March 2018 Keynote Speaker Cancer Survivor Day. Co-Director - International Facial Nerve Symposium Cedars-Sinai Medical Center. August 2017 August 2008 Lectures: - Outpatient Parotidectomy - Facial Nerve Paralysis & Nasal Minimally Invasive Thyroid & Parahtyroid Surgery, Obstruction Surgical Society. El Salvador - Parotid Tumors January 2008 - Parotidectomy Technique Treatment Of Nasal Obstruction. Advances in Facial Advances in Treatment of Hyperparathyroidism Plastics & Reconstruction. 2007 & 2008 Surgery Grand Rounds St. Vincent Medical Center Grand Rounds, June October 2017 2005 Diagnosis & Treatment of Hyperparathyroidism Endoscopic Laser Laryngeal Surgery. Head & Neck Otolaryngology Update Tumor Board – Cedars-Sinai March 2017 Medical Center. March 2006 Hyperparathyroidism Laryngeal Cancer, Course: Clinical Management of Research Study Club Head and Neck Cancers. January 2017 Cedars-Sinai Medical Center, November 2005 Advances in Head & Neck Surgical Oncology and Diagnosis & Treatment of Hyperparathyroidism Reconstruction. Endocrine Rounds Cedars-Sinai Medical Center Physical Medicine & March 2016 Rehab Grand Rounds, February 2004 Parotid Reconstruction. Advances in Multi-Specialty Aesthetic and Reconstructive Plastic Surgery Symposium. November 2014 Advances in Head & Neck Surgical Oncology Cedars-Sinai Medical Center Surgery Grand Rounds, Advances in Parotid Surgery & Reconstruction. March 2005 Advances in Multi-Specialty Aesthetic and Reconstructive Plastic Surgery Symposium. November 2012 PRESENTATIONS (Cont.) Current Concepts in Blephroplasty and Surgical Vocal Health for the Professional Voice User, Hans Complications. UCLA Division of Head & Neck Von Laden Laryngeal Course. Surgery Cedars-Sinai Medical Center, May 2004 Los Angeles, CA. February 2000 Esthesioneuroblastoma: Comparison of the Different Multimodal Therapies. Publication Rate of Scientific Presentations at AAO. Paul H. Ward Society, 13th annual Scientific/Research American Academy of Otolaryngolgy – Head and Session. Los Angeles, Ca. June 2001 Neck Surgery Annual Meeting. New Orleans, La. Nitric Oxide Inhibitors Increase the Rate of September 1999 Microvascular Thrombosis. American Academy of Facial Plastic and Clonal and Proliferative Activity of Single vs. Multiple Reconstructive, Denver, CO. Parathyroid Adenoma. September 2001 15th annual Bay Area Research Symposium. Comparative Analysis of Radiobilogical Parameters San Francisco, Ca. of Thyroid and Non-Thyroid Cancer Cell Lines and June1999 Correlation with Clinical Radioresponsiveness. The Clonal and Proliferative Activity of Single vs. Multiple 104th Annual Meeting of the American Laryngological, Parathyroid Adenoma. Rhinological and Otological (Triological) Society. Paul H. Ward Society, 11th annual Scientific/Research Palm Desert,
Load more

Recommended publications
  • Emerging Concepts and Novel Strategies in Radiation Therapy for Laryngeal Cancer Management
    cancers Review Emerging Concepts and Novel Strategies in Radiation Therapy for Laryngeal Cancer Management Mauricio E. Gamez 1,*, Adriana Blakaj 2, Wesley Zoller 1 , Marcelo Bonomi 3 and Dukagjin M. Blakaj 1 1 Division of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA; [email protected] (W.Z.); [email protected] (D.M.B.) 2 Department of Therapeutic Radiology, Yale School of Medicine, 35 Park St., New Haven, CT 06519, USA; [email protected] 3 Department of Internal Medicine, Division of Medical Oncology, The Ohio State University Wexner Medical Center, 320 West 10th Avenue, Columbus, OH 43210, USA; [email protected] * Correspondence: [email protected] Received: 25 May 2020; Accepted: 15 June 2020; Published: 22 June 2020 Abstract: Laryngeal squamous cell carcinoma is the second most common head and neck cancer. Its pathogenesis is strongly associated with smoking. The management of this disease is challenging and mandates multidisciplinary care. Currently, accepted treatment modalities include surgery, radiation therapy, and chemotherapy—all focused on improving survival while preserving organ function. Despite changes in smoking patterns resulting in a declining incidence of laryngeal cancer, the overall outcomes for this disease have not improved in the recent past, likely due to changes in treatment patterns and treatment-related toxicities. Here, we review emerging concepts and novel strategies in the use of radiation therapy in the management of laryngeal squamous cell carcinoma that could improve the relationship between tumor control and normal tissue damage (therapeutic ratio). Keywords: laryngeal cancer; radiotherapy; IMRT; IGRT; SABR; de-escalation therapy 1.
    [Show full text]
  • Laryngeal Cancer Survivorship
    About the Authors Dr. Yadro Ducic MD completed medical school and Head and Neck Surgery training in Ottawa and Toronto, Canada and finished Facial Plastic and Reconstructive Surgery at the University of Minnesota. He moved to Texas in 1997 running the Department of Otolaryngology and Facial Plastic Surgery at JPS Health Network in Fort Worth, and training residents through the University of Texas Southwestern Medical Center in Dallas, Texas. He was a full Clinical Professor in the Department of Otolaryngology-Head Neck Surgery. Currently, he runs a tertiary referral practice in Dallas-Fort Worth. He is Director of the Baylor Neuroscience Skullbase Program in Fort Worth, Texas and the Director of the Center for Aesthetic Surgery. He is also the Codirector of the Methodist Face Transplant Program and the Director of the Facial Plastic and Reconstructive Surgery Fellowship in Dallas-Fort Worth sponsored by the American Academy of Facial Plastic and Reconstructive Surgery. He has authored over 160 publications, being on the forefront of clinical research in advanced head and neck cancer and skull base surgery and reconstruction. He is devoted to advancing the care of this patient population. For more information please go to www.drducic.com. Dr. Moustafa Mourad completed his surgical training in Head and Neck Surgery in New York City from the New York Eye and Ear Infirmary of Mt. Sinai. Upon completion of his training he sought out specialization in facial plastic, skull base, and reconstructive surgery at Baylor All Saints, under the mentorship and guidance of Dr. Yadranko Ducic. Currently he is based in New York City as the Division Chief of Head and Neck and Skull Base Surgery at Harlem Hospital, in addition to being the Director for the Center of Aesthetic Surgery in New York.
    [Show full text]
  • NCCN Guidelines for Head and Neck Cancers V.1.2019 – Follow-Up on 01/17/2019
    NCCN Guidelines for Head and Neck Cancers V.1.2019 – Follow-Up on 01/17/2019 Guideline Page Panel Discussion/References Institution Vote and Request YES NO ABSTAIN ABSENT SALI-4/CHEM-A Based on a review of data and discussion, the panel 21 0 2 4 External request: consensus supported the inclusion of NTRK therapy (eg, larotrectinib) as an option for recurrent NTRK gene fusion- Submission from Bayer HealthCare positive salivary gland tumors with distant metastases, PS Pharmaceuticals suggesting the following for 0-3 (on page SALI-4). This is a category 2A consideration: recommendation. 1. Principles of Systemic Therapy: Add bullet “Larotrectinib is recommended for tumors harboring an NTRK gene fusion.” See Submission for references. 2. First-line Single-agent or Second- line/Subsequent Therapy: Add “larotrectinib if NTRK+” 3. Salivary Gland Tumors, Unresectable Disease or Distant Metastases: Add “larotrectinib if NTRK+” CHEM-A (1 of 6) Based on the discussion and noted references, the panel Internal request: consensus was that cetuximab + concurrent RT has limited clinical use for the primary treatment of: Panel comment to review the data for cetuximab Hypopharynx, larynx, p16-negative oropharynx 16 5 2 4 + concurrent RT as a primary definitive therapy cancers option for oropharyngeal cancer (p16-negative p16-positive oropharynx cancers 10 10 3 4 and p16-positive), hypopharyngeal cancer, and The category was changed from a category 1 to a 2B laryngeal cancer. recommendation for cancers of the oropharynx (p16- positive and p16-negative), hypopharynx or larynx. References: Gillison ML, Trotti AM, Harris J, et al. Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non-inferiority trial.
    [Show full text]
  • What You Need to Know About™ Cancer of the Larynx
    What You Need To Know About TM Cancer National Cancer Institute of the Larynx U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute Services This is only one of many free booklets for people with cancer. You may want more information for yourself, your family, and your doctor. NCI offers comprehensive research-based information for patients and their families, health professionals, cancer researchers, advocates, and the public. • Call NCI’s Cancer Information Service at 1–800–4–CANCER (1–800–422–6237) • Visit us at http://www.cancer.gov or http://www.cancer.gov/espanol • Chat using LiveHelp, NCI’s instant messaging service, at http://www.cancer.gov/ livehelp • E-mail us at [email protected] • Order publications at http://www.cancer.gov/ publications or by calling 1–800–4–CANCER • Get help with quitting smoking at 1–877–44U–QUIT (1–877–448–7848) Contents About This Booklet 1 The Larynx 2 Cancer Cells 5 Risk Factors 7 Symptoms 9 Diagnosis 9 Staging 12 Treatment 13 Second Opinion 25 Nutrition 26 Rehabilitation 27 Follow-up Care 29 Sources of Support 29 Taking Part in Cancer Research 31 Dictionary 32 National Cancer Institute Publications 40 National Institute on Deafness and Other Communication Disorders 42 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health About This Booklet This National Cancer Institute (NCI) booklet is about cancer* that starts in the larynx. Another name for this disease is laryngeal cancer. Each year in the United States, more than 10,000 men and about 3,000 women learn they have cancer of the larynx.
    [Show full text]
  • Laryngeal and Hypopharyngeal Cancer Early Detection, Diagnosis, and Staging Detection and Diagnosis
    cancer.org | 1.800.227.2345 Laryngeal and Hypopharyngeal Cancer Early Detection, Diagnosis, and Staging Detection and Diagnosis Finding cancer early often allows for more successful treatment options. Some early cancers may have signs and symptoms that can be noticed, but that's not always the case. ● Can Laryngeal and Hypopharyngeal Cancers Be Found Early? ● Signs and Symptoms of Laryngeal and Hypopharyngeal Cancers ● Tests for Laryngeal and Hypopharyngeal Cancers Stages and Outlook (Prognosis) After a cancer diagnosis, staging provides important information about the extent of cancer in the body and likely response to treatment. ● Laryngeal Cancer Stages ● Hypopharyngeal Cancer Stages ● Survival Rates for Laryngeal and Hypopharyngeal Cancers Questions to Ask About Laryngeal and Hypopharyngeal Cancer Here are some questions you can ask your cancer care team to help you better understand your cancer diagnosis and treatment options. ● Questions to Ask Your Doctor About Laryngeal or Hypopharyngeal Cancer 1 ____________________________________________________________________________________American Cancer Society cancer.org | 1.800.227.2345 Can Laryngeal and Hypopharyngeal Cancers Be Found Early? Screening is testing for cancer or pre-cancer in people who have no symptoms of the disease. Screening tests may find some types of cancer early, when treatment is most likely to be successful. For now, there is no screening test to find laryngeal and hypopharyngeal cancers early. These cancers are often hard to find and diagnose without complex tests. Because these cancers are not common, and the tests need specialized doctors, neither the American Cancer Society nor any other group recommends routine screening for these cancers. Sometimes though, laryngeal and hypopharyngeal cancers can be found early.
    [Show full text]
  • Association Between Laryngeal Cancer and Asbestos Exposurea
    Clinical Review & Education JAMA Otolaryngology–Head & Neck Surgery | Review Association Between Laryngeal Cancer and Asbestos Exposure A Systematic Review Ashley P. O’Connell Ferster, MD; Jane Schubart, PhD; Yesul Kim, BS; David Goldenberg, MD IMPORTANCE It has been debated whether a link exists between laryngeal cancer and asbestos exposure. Prior systematic reviews have been conducted on this topic, but no updates have been performed on the most recent literature since 2000. OBJECTIVE To provide an updated systematic review of the association between laryngeal cancer and asbestos exposure. EVIDENCE ACQUISITION A search of electronic databases, including PubMed and the Cochrane Library, was performed for articles published between January 1, 2000, and April 30, 2016. Search terms, including laryngeal cancer and asbestos, were used to identify publications reviewing the risk of laryngeal cancer in association with asbestos exposure. Studies analyzing this association that were published in any language and translated reliably were included. Two independent reviewers assessed articles based on predetermined eligibility criteria. Each study was reviewed for quality using the Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence and assessed for their findings of support for or against a correlation between asbestos exposure and laryngeal cancer. FINDINGS A total of 160 studies were retrieved from all databases, and 2 additional articles were identified by cross-references. Of the 162 articles screened, 15 articles comprising 438 376 study participants were included in this review. Of these 15 studies, 10 showed no correlation between asbestos exposure and laryngeal cancer. The remaining 5 studies claimed a correlation between asbestos exposure and incidence of laryngeal cancer, although only 1 accounted for smoking or alcohol exposure while 3 others did not, and 1 study included only 2 patients.
    [Show full text]
  • Tumour Control Probability of Stage III Inoperable Non-Small Cell Lung Tumours After Sequential Chemo-Radiotherapy
    ANTICANCER RESEARCH 25: 4655-4662 (2005) Tumour Control Probability of Stage III Inoperable Non-small Cell Lung Tumours after Sequential Chemo-radiotherapy S.Y. EL SHAROUNI, H.B. KAL and J.J. BATTERMANN Department of Radiation Oncology, Q 00.118, University Medical Centre Utrecht, Post Box 85500, 3508 GA Utrecht, The Netherlands Abstract. The aim of this study was to investigate the induction chemotherapy with gemcitabine and cisplatin is influence of the duration of waiting time between the end of employed for downstaging the tumours with the aim of induction chemotherapy and the start of radiotherapy on further treatment with ionising radiation or surgery. If no tumour control probability (TCP). Patients and Methods: stringent arrangements are made, the waiting time between Twenty-three patients with inoperable stage III non-small cell induction chemotherapy and irradiation may be lung cancer (NSCLC) received induction chemotherapy considerable. In general, waiting times for radiotherapy are followed by radiotherapy. The mean waiting period between the a cause for concern in many radiotherapy departments. end of induction chemotherapy and the start of radiotherapy Fortin et al. (2) analysed the impact of delaying treatment was 80 days; in this period, the median tumour volume on the outcome of 623 patients with early head-and-neck increased by a factor of about 6. The Poisson model for TCP (H&N) squamous cell carcinomas and concluded that and the linear-quadratic model were used to calculate changes delaying radiotherapy had a deleterious effect. Waaijer and in TCP in the waiting time. Results: The 2-year survival of colleagues (3) investigated tumour growth of oropharyngeal patients treated with curative intent was 8%, lower than the tumours in the waiting time for radiotherapy.
    [Show full text]
  • Original Article Expression of IRAK1 in Lung Cancer Tissues and Its Clinicopathological Significance: a Microarray Study
    Int J Clin Exp Pathol 2014;7(11):8096-8104 www.ijcep.com /ISSN:1936-2625/IJCEP0002475 Original Article Expression of IRAK1 in lung cancer tissues and its clinicopathological significance: a microarray study Xiuling Zhang1*, Yiwu Dang1*, Ping Li1, Minhua Rong2, Gang Chen1 1Department of Pathology, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, P. R. China; 2Department of Medical Research, Affiliated Cancer Hospital, Guangxi Medical University, 71 Hedi Road, Nanning 530021, Guangxi Zhuang Autonomous Region, P. R. China. *Equal contributors. Received September 12, 2014; Accepted October 31, 2014; Epub October 15, 2014; Published November 1, 2014 Abstract: The interleukin-1 receptor associated kinases 1 (IRAK1) is a down stream effector molecule of the toll like receptor (TLR) signaling pathway, which is involved in inflammation, autoimmunity and cancer. However, the role of IRAK1 in lung cancer remains unclarified. Herein, we investigated the protein expression and the clinicopathological significance of IRAK1 in 3 formalin-fixed paraffin-embedded lung cancer tissue microarrays by using immunohisto- chemistry, which included 365 tumor and 30 normal lung tissues. We found that the expression of IRAK1 in lung cancer was significantly higher compared with that in normal lung tissues (P=0.002). Receiver operating character- istic (ROC) curves were generated to evaluate the power of IRAK1 to distinguish lung cancer from non-cancerous lung tissue. The area under curve (AUC) of ROC of IRAK1 was 0.643 (95% CI 0.550~0.735, P=0.009). Additionally, IRAK1 expression was related to clinical TNM stage (r=0.241, P < 0.001), lymph node metastasis (r=0.279, P < 0.001) and tumor size (r=0.299, P < 0.001) in lung cancer.
    [Show full text]
  • Small Cell Neuroendocrine Tumor of the Larynx – a Small Case Series
    Color profile: Disabled Composite 150 lpi at 45 degrees Coll. Antropol. 36 (2012) Suppl. 2: 201–204 Case report Small Cell Neuroendocrine Tumor of the Larynx – A Small Case Series Anton Miki}1,2, Elvir Zvrko3,4, Aleksandar Trivi}1,2, Du{an Stefanovi}1 and Mileta Golubovi}4,5 1 Clinical Center of Serbia, Institute of Otorhinolaryngology and Maxillofacial Surgery, Belgrade, Serbia 2 University of Belgrade, School of Medicine, Belgrade, Serbia 3 Clinical Center of Montenegro, Clinic of Otorhinolaryngology and Maxillofacial Surgery, Podgorica, Montenegro 4 University of Montenegro, School of Medicine, Podgorica, Montenegro 5 Clinical Center of Montenegro, Center of Pathology and Forensic Medicine, Podgorica, Montenegro ABSTRACT Neuroendocrine tumors are the most common nonsquamous types of laryngeal neoplasms. They are classified as typi- cal carcinoids, atypical carcinoids, small-cell neuroendocrine carcinomas, and paragangliomas. The aim of the paper is to present four patients with small-cell neuroendocrine tumor arising in larynx. There were one woman and three men whose ages were 47–77 years; all of them had metastases when first seen. The clinical presentation and management of such type of tumor are discussed. Small-cell neuroendocrine carcinomas are very aggressive neoplasms. Patients could benefit from surgery, but radiotherapy and chemotherapy remain the treatment of choice. Examination of a large series is required to define the most useful diagnostic methods and the most successful treatment modalities. Key words: laryngeal cancer, small cell carcinoma, neuroendocrine tumors Introduction Laryngeal cancer is the most common head-and-neck roendocrine carcinoma), small cell neuroendocrine carci- cancer and accounts 2.4% of new cancer diagnoses annu- noma (poorly differentiated neuroendocrine carcinoma, ally in men1.
    [Show full text]
  • Respiratory System Pathologies in Patients Who Underwent Total Laryngectomy Due to Larynx Cancer
    ISSN: 2455-1759 DOI: https://dx.doi.org/10.17352/aor CLINICAL GROUP Received: 16 March, 2020 Research Article Accepted: 30 April, 2020 Published: 02 May, 2020 *Corresponding author: Hakan Celikhisar, Chest Respiratory system Diseases Specialist, Izmir University of Economics, Vocational School of Health Science, Izmir, Turkey, E-mail: pathologies in patients who Keywords: Laryngeal cancer; Total laryngectomy; Respiratory system underwent total laryngectomy https://www.peertechz.com due to larynx cancer Hakan Celikhisar* Chest Diseases Specialist, Izmir University of Economics, Vocational School of Health Science, Izmir, Turkey Abstract Aim: The aim of the present study was to examine the long-term respiratory system pathologies that may develop in larynx cancer patients who have undergone total laryngectomy operation. Method: A total of 54 larynx cancer patients who have undergone total laryngectomy operation admitted to our clinic during July 2016 – November 2019 due to accompanying respiratory system pathology were retrospectively evaluated with regard to clinical radiologic and histopathologic fi ndings. The fi ndings were examined comparatively with relevant literature data. Results: All cases were male with an age average of 65+8 years. The cases had a smoking history of 62+42 packs/year on average. All cases had been subject to total laryngectomy operation due to epidermoid type larynx carcinoma and they had tracheostomy. Non-small cell lung carcinoma was determined in 14 cases (26 %), chronic obstructive pulmonary disease (COPD) in 12 cases (22 %), pneumonia in 8 cases (15 %), inactive lung tuberculosis in 4 cases (7.5 %), malignant pleurisy in 2 cases (3.75 %) and metastatic lung cancer in 2 cases (3.75 %).
    [Show full text]
  • Chrysotile Fibers in Tissue Adjacent to Laryngeal Squamous Cell Carcinoma
    Modern Pathology (2020) 33:228–234 https://doi.org/10.1038/s41379-019-0332-7 ARTICLE Chrysotile fibers in tissue adjacent to laryngeal squamous cell carcinoma in cases with a history of occupational asbestos exposure 1 2 3 3 4 Stephanie K. Wronkiewicz ● Victor L. Roggli ● Benjamin H. Hinrichs ● Ady Kendler ● Rondi A. Butler ● 5,6 7,8 9,10 11 4,12 Brock C. Christensen ● Carmen J. Marsit ● Heather H. Nelson ● Michael D. McClean ● Karl T. Kelsey ● Scott M. Langevin 13,14 Received: 25 March 2019 / Revised: 9 May 2019 / Accepted: 3 July 2019 / Published online: 5 August 2019 © United States & Canadian Academy of Pathology 2019 Abstract Asbestos describes a group of naturally occurring fibrous silicate mineral compounds that have been associated with a number of respiratory maladies, including mesothelioma and lung cancer. In addition, based primarily on epidemiologic studies, asbestos has been implicated as a risk factor for laryngeal and pharyngeal squamous cell carcinoma (SCC). The main objective of this work was to strengthen existing evidence via empirical demonstration of persistent asbestos fibers embedded in the tissue surrounding laryngeal and pharyngeal SCC, thus providing a more definitive biological link between n = n = 1234567890();,: 1234567890();,: exposure and disease. Six human papillomavirus (HPV)-negative laryngeal ( 4) and pharyngeal ( 2) SCC cases with a history working in an asbestos-exposed occupation were selected from a large population-based case–control study of head and neck cancer. A laryngeal SCC case with no history of occupational asbestos exposure was included as a control. Tissue cores were obtained from adjacent nonneoplastic tissue in tumor blocks from the initial primary tumor resection, and mineral fiber analysis was performed using a scanning electron microscope equipped with an energy dispersive X-ray analyzer (EDXA).
    [Show full text]
  • Larynx Cancer
    Larynx Cancer Page 1 of 8 Disclaimer: This algorithm has been developed for MD Anderson using a multidisciplinary approach considering circumstances particular to MD Anderson’s specific patient population, services and structure, and clinical information. This is not intended to replace the independent medical or professional judgment of physicians or other health care providers in the context of individual clinical circumstances to determine a patient's care. This algorithm should not be used to treat pregnant women. Note: Consider Clinical Trials as treatment options for eligible patients. INITIAL EVALUATION CONSULTATIONS PRE-TREATMENT EVALUATION ● Confirm outside pathology ● If no biopsy/pathology, consider ● History examination under anesthesia (EUA), ○ Chief complaint direct laryngoscopy (DL), biopsy, ○ History of present illness and previous treatment esophagoscopy ● Past medical history including but not limited to: ● Radiation Oncology ○ Social history (including tobacco and alcohol use) ● Thoracic/Head and Neck Medical Glottic See Page 2 ○ Previous radiation therapy – head and neck, Oncology (THNMO) for patients thoracic, breast (for previous primary or benign with stage III or IV diagnosis) ● Dental Oncology for dentulous Supraglottic: ● Physical examination patients except those receiving Patient information Node negative (based ○ Full head and neck examination narrow field radiation See Page 3 presented at on clinical and/or ○ Fiberoptic exam ● Speech Pathology for all patients multidisciplinary radiographic imaging) ○ Videostroboscopy
    [Show full text]