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The 53Rd Annual MIKI Meeting-In-Miniature

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The 53Rd Annual MIKI Meeting-In-Miniature The 53rd Annual MIKI Meeting-in-Miniature April 10th to 12th, 2015 The University of Kansas School of Pharmacy Lawrence, KS Welcome to the 53rd Annual MIKI Meeting! On behalf of the Department of Medicinal Chemistry at the University of Kansas, we welcome you to Lawrence, Kansas and the 53rd Annual MIKI Meeting-in-Miniature! This weekend provides a unique opportunity to become reacquainted with old friends and continue to expand your network in a dynamic and collaborative environment. We look forward to hosting such a brilliant group of young scientists. We would also like to thank you for your scientific contributions to the meeting because without those we would not be here! Since its inauguration in 1963, this meeting-in-miniature has provided graduate students from the universities of Minnesota, Illinois at Chicago, Kansas, and Iowa with the opportunity to participate in a larger scientific community by organizing and hosting the conference. The location of the meeting rotates between one of the four participating schools each year, with a full cycle completed every four years. In addition to allowing students to present their research, MIKI allows both faculty and students to exchange ideas, learn about other fields, and expand their network. The MIKI Keynote Address has been presented by world-class scientists, including multiple Nobel Prize winners and ACS Division of Medicinal Chemistry Hall of Fame Inductees. This year we are proud to host Dr. Bruce Roth. Dr. Roth is the inventor of Lipitor®, the best selling drug of all time. Currently, he is the Senior Vice President of Small Molecule Drug Discovery at Genentech Research and Early Development. We hope that you have the opportunity to enjoy the meeting, encourage others, and learn something new! Sincerely, The MIKI 2015 Organizing Committee Chair: Molly Lee Faculty Chair: Ryan Altman, Ph.D. 2015 MIKI Organizing Committee Chairs Leah Forsberg Manwika Charaschanya Brett Ambler Doug Orsi Rachel Saylor Gavin Gao Additional Members of the 2015 MIKI Organizing Committee Elyse Petrunak Vince Crowley Huiyong Ma Anuj Khandelwal Rachel Davis Jessica Hall Rakesh Vekariya Andrew Riley Caleb Vogt Solomon Gisemba Stephanie Johnson Jordan Hunt Casey Henderson ACKNOWLEDGEMENTS Generous supporters have contributed greatly to the success of this meeting. Without contributions from the following sponsors, the 53rd Annual MIKI Meeting-in-Miniature would not be possible. Thank you to all of the 2015 MIKI supporters! This program is supported by a grant from Genentech and an educational grant from Pfizer Inc. Friday, April 10, 2015 3:00 – 6:00 p.m. Registration Open Best Western Hotel Hotel Check-in 6:30 – 9:30 p.m Welcome Reception Oread Hotel Griffith Ballroom Saturday, April 11, 2015 8:00 – 9:00 a.m. Breakfast School of Pharmacy, (SOP) Lower level Poster Setup SOP Atrium Opening Remarks and Welcome 9:00 – 9:20 a.m. Chancellor Bernadette Gray-Little SOP 2020 Professor Gary Grunewald Session 1 SOP 2020 9:20 – 9:40 a.m. Elbek K. Kurbanov The University of Minnesota “Structure-Based Inhibitor Design for Anthrax Toxin Lethal Factor” 9:40 – 10:00 a.m. Chaitanya Kulkarni The University of Iowa “Synthetic Approaches to Novel Quinazoline-2,4-diones” 10:00 – 10:20 a.m. Huiyong Ma The University of Kansas “Development of Kappa Opioid Receptor Agonists and Antagonists based on Novel Scaffolds” 10:20 – 10:40 a.m. Hitisha Patel The University of Illinois at Chicago “Exploiting the Therapeutic Potential of Estrogen for the Treatment of Tamoxifen Resistant Breast Cancer” 10:40 – 11:00 a.m. Break SOP Atrium Keynote Address SOP 2020 11:00 – 12:00 p.m. Dr. Bruce Roth Overflow: SOP 3020 Genentech Research and Early Development “The Discovery and Development of LIPITOR®. Would anyone make this molecule today?” 12:00 – 1:30 p.m. Lunch SOP, Lower level Poster Session SOP, Atrium 1:30 – 2:30 p.m. Odd Numbered Posters Present 2:30 – 3:30 p.m. Even Numbered Posters Present Session 2 SOP 2020 3:30 – 3:50 p.m. Josephine H. Schamp The University of Iowa “Neurodegeneration: The Role of Dopamine Metabolites, Oxidative Stress, and Antioxidants” 3:50 – 4:10 p.m. Brett R. Ambler The University of Kansas “Copper-Catalyzed Methods for Accessing Trifluoromethane-containing Products” 4:10 – 4:30 p.m. Rui Xiong The University of Illinois at Chicago “Lead Based Development and Evaluation of Partial Agonist Selective Estrogen Mimics (PASEMs) in Tamoxifen Resistant Breast Cancer” 4:30 – 4:50 p.m. Jingjing Shen The University of Minnesota “Design and Characterization of Bispecific T-cells Engaging Chemically Self-assembled Antibody Nanorings(CSANs) with Potential for Treatment of B Cell Malignancies” 5:30 – 7:00 p.m. Faculty Reception Abe & Jake’s Landing 7:00 – 10:00 p.m. Formal Banquet Dinner Abe & Jake’s Landing Sunday, April 12, 2015 8:00 – 9:00 a.m. Breakfast SOP, Lower level Hotel Check-out Prior to Breakfast Session 3 SOP 2020 9:00 – 9:20 a.m. Solomon A. Gisemba The University of Kansas “Peptide Ring Closing Metathesis Reactions: Minimizing Side Reactions in Arodyn Analogs” 9:20 – 9:40 a.m. Jing Li The University of Illinois at Chicago “TDP1 Promotes Assembly of Non-homologous End Joining Protein Complexes on DNA” 9:40 – 10:00 a.m. Adam T. Zarth The University of Minnesota “N′-Nitrosonornicotine 5′-Hydroxylation Causes DNA Damage in Rats” 10:00 – 10:20 a.m. Michael P. Hayes The University of Iowa "Fragment-based Screening Against Regulator of G Protein Signaling 17" 10:20 –10:40 a.m. Break SOP Atrium Session 4 SOP 2020 10:40 – 11:00 a.m. Chengsong Jiao The University of Illinois at Chicago “The Synthesis of Hydroxymethylene Phosphonate Analogs of Polyphosphates” 11:00 – 11:20 a.m. Bo Zhou The University of Minnesota “Target Identification and Mechanism Elucidation of Chalcones’ Cytotoxicity via Photoaffinity Probes” 11:20 – 11:40 a.m. Ben Williamson The University of Iowa "Investigations Toward Overcoming Drug Resistance in Bacteria through the Use of Novel Fluoroquinolones" 11:40 a.m. – 12:00 p.m. Gaurav Garg The University of Kansas “Development of Biphenylamides as Hsp90 C-Terminal Inhibitors” 12:00 p.m. Concluding Remarks SOP 2020 Faculty Meeting Boxed Lunches Served SOP Atrium Buses Depart MIKI KEYNOTE SPEAKERS Year Host Speaker Association 2015 Kansas Dr. Bruce D. Roth Genentech Inc. 2014 Illinois Dr. Paul A. Wender Stanford University 2014 Minnesota Dr. Marvin J. Miller University of Notre Dame 2013 Iowa Dr. Heidi E. Hamm Vanderbilt University 2012 Kansas Dr. Dennis C. Liotta Emory University 2011 Illinois Dr. Tomáš Hudlický Brock University 2010 Minnesota Dr. Dale Boger Scripps Research Institute 2009 Iowa Dr. Daniel Kahne Harvard University 2008 Kansas Dr. Albert Padwa Emory University 2007 Illinois Dr. William Fenical University of California, San Diego 2006 Minnesota Dr. Christopher Lipinski Pfizer Pharmaceuticals 2005 Iowa Dr. Kenner Rice National Institutes of Health 2004 Kansas Dr. C. Dale Poulter University of Utah 2003 Illinois Dr. Richard B. Silverman Northwestern University 2002 Minnesota Dr. Andrew Hamilton Yale University 2001 Iowa Dr. Michael Marletta University of Michigan 2000 Kansas Dr. Roger M. Friedinger Merck Research Laboratories 1999 Illinois Dr. Richard A. Lerner Scripps Research Institute 1998 Minnesota Dr. John Montgomery Biocryst Pharmaceutical, Inc. 1997 Iowa Dr. David Nichols Purdue University 1996 Kansas Dr. Paul Anderson Dupont Merck Pharmaceutical 1995 Illinois Dr. Arthur Patchett Merck Research Laboratories 1994 Minnesota Dr. Daniel Rich University of Wisconsin, Madison 1993 Iowa Dr. Laurence Hurley University of Texas, Austin 1992 Kansas Dr. Julius Rebek Massachusetts Institute of Technology 1991 Illinois Dr. Koji Nakanishi Columbia University 1990 Minnesota Dr. John Katzenellenbogen University of Illinois, Urbana-Champaign 1989 Iowa Dr. Carl Djerassi Stanford University 1988 Kansas Dr. William Roush Indiana University 1987 Illinois Dr Joseph Fried University of Chicago 1986 Minnesota Dr. David Triggle SUNY Buffalo 1985 Iowa Dr. Alan Karitzky University of Florida 1984 Wisconsin Dr. Paul Bartlett University of California, Berkeley 1983 Kansas Dr. Henry Rapoport University of California, Berkeley 1982 Illinois Dr. Harry Wasserman Yale University 1981 Minnesota Dr. Eugene Jorgensen University of California, San Francisco 1980 Iowa Dr. Alan Sartorelli Yale University 1979 Kansas Dr. Albert Meyers Colorado State University 1978 Illinois Dr. Heinz Floss Purdue University 1977 Minnesota Dr. Donald Jerina National Institutes of Health 1976 Iowa Dr. Everett May National Institutes of Health 1975 Kansas Dr. Marjorie Horning Baylor University 1974 Illinois Dr. Arnold Brossi Hoffman-LaRoche 1973 Minnesota Dr. Gertrude Ellion Burroughs-Wellcome 1972 Iowa Dr. Bernard Belleau University of Ottawa 1971 Kansas Dr. Corwin Hansch Pomona College 1970 Illinois Dr. Everett Maynert University of Illinois 1969 Minnesota Dr. Bernard Baker University of California, Santa Barbara 1968 Iowa Dr. Julius Axelrod National Institutes of Health 1967 Kansas Dr. Richard Schowen University of Kansas 53rd ANNUAL MIKI MEETING KEYNOTE SPEAKER Dr. Bruce Roth Senior Vice President, Small Molecule Drug Discovery Genentech Research and Early Development Bruce Roth received his BS in Chemistry in 1976 (St. Joseph’s College), his Ph.D. Organic Chemistry in 1981 (Iowa State University) and after a postdoctoral fellowship at the University of Rochester, joined Warner-Lambert/Parke- Davis Research in 1982, where he rose to the position of Vice President, Chemistry. He is best known as the inventor of Lipitor®, the largest selling drug in the history of the pharmaceutical industry, for which he has received numerous awards, including the 2013 Perkin Medal, the highest award given to industrial chemists in the United States and the 2015 National Academy of Sciences award for Chemistry in Service to Society. Bruce served as Vice President of Chemistry at the Pfizer Global Research and Development, Ann Arbor Laboratories from 2000-2007. He also served as an adjunct associate professor in the Department of Bruce D.
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