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Xiaoliang Sunney Xie - Wikipedia Xiaoliang Sunney Xie - Wikipedia https://en.wikipedia.org/wiki/Xiaoliang_Sunney_Xie Xiaoliang Sunney Xie Xiaoliang Sunney Xie (Chinese: 谢晓�; born 1962 in Beijing, China) is Xiaoliang Sunney Xie an American biochemist, considered a founding father of single-molecule biophysical chemistry and single-molecule enzymology$[2] Contents Early life Research Honors and awards Selected Literature Single-Cell Genomics Gene Expression and Regulation Single Molecule Enzymology Coherent Raman Imaging Born June 24, 1962 Single Molecule Imaging Beijing, China References Education BSc in External links Chemistry from Peking University Early life PhD in Physical Chemistry from 'e received his B.Sc$ in Chemistr" from Peking ,niversit" in 1984, and UC San Diego his Ph.D$ in Physical Chemistry in 1990 from ,niversit" of California at Known for Single Molecule San Diego$ After a brief postdoctoral appointment at ,niversit" of Enzymology, Chicago, he joined Pacific Northwest National Laboratory, 2here he rose Coherent from Senior 4esearch Scientist to Chief Scientist$ In 1998, he became the Raman first tenured professor at 'arvard ,niversity among Chinese Scholars 2ho Imaging, came to the United States since Chinese economic reform$ Single Cell Genomics Research Awards Albany Prize in 'e had been the Mallinckrodt *rofessor of Chemistry and Chemical Medicine and Biology at 'arvard University until 2018, when he became the Lee Shau- Biomedical kee *rofessor of Peking ,ni(ersity. Currently, he is also the Director of Research 2015, Biomedical Pioneering 5nnovation Center (BIOP5C), and the /irector of Peter Debye Beijing Advanced Innovation Center for Genomics (ICG), both at Peking Award in 1 of 7 11/26/19, 2:15 AM Xiaoliang Sunney Xie - Wikipedia https://en.wikipedia.org/wiki/Xiaoliang_Sunney_Xie ,niversit"$ Physical Chemistry As a pioneer of single-molecule biophysical chemistry, coherent Raman 2015, scattering microscopy, and single-cell genomics, he made major Ellis R. contributions to the emergence of these fields. Furthermore, he has made Lippincott significant advances on medical applications of label-free optical imaging Award 2013, and single-cell genomics$ In !articular, his inventions in single-cell Biophysical genomics have been used in in vitro fertilization to benefit hundreds of Society couples in China by avoiding the transmission of monogenic diseases to Founders Award their newborns. 2012 As of Jan 2019, Xie has published over 226 papers. More than forty of his NAS 2011 students and post-doctorates have become professors at major universities NAM 2016 around the world, and t2o are co-founders of start-up companies. CAS 2017 Professor Xie’s current research interests include the following scientific, Scientific career technological, and medical areas: Fields Biophysical Chemistry, Scientific: Single-molecule enzymology, Single- molecule biophysical chemistry, Gene expression and Optical regulation, Epigenetics, Mechanism of cell Imaging, differentiation and reprogramming, Chromosome Genomics structure and dynamics, and Genomic instability; Technological: Single-molecule imaging, Single-cell Institutions Harvard genomics, Coherent Raman scattering microscopy, DNA University sequencing; Peking Medical: Preimplantation genetic testing in in vitro University fertilization, and Early cancer diagnosis Doctoral John Douglas [1] Honors and awards advisor Simon Qiu Shi Outstanding Scientist Award, Qiu Shi Science & Technologies Foundation (2017)[3] 2017, Foreign member of the Chinese Academy of Sciences[4] 2016: Member of the National Academy of Medicine[5] 2015: Albany Medical Center Prize[6] 2015: Peter Debye Award in Physical Chemistry, American Chemical Society[7] 2014: Fellow of the Optical Society of America 2013: NIH Director's Pioneer Award[8] 2013: Ellis R. Lippincott Award, Optical Society of America and Society for Applied Spectroscopy[9] 2012: Edward Mack, Jr. Lecture, OSU 2012: Harrison Howe Award, Rochester Section of the American Chemical Society (http://ww w.chem.rochester.edu/howe/current.php) 2012: Fellow of the American Academy of Microbiology 2012: Biophysical Society Founders Award 2011: Member of the National Academy of Sciences 2 of 7 11/26/19, 2:15 AM Xiaoliang Sunney Xie - Wikipedia https://en.wikipedia.org/wiki/Xiaoliang_Sunney_Xie 2009: Ernest Orlando Lawrence Award 2008: Fellow of the American Physical Society 2008: Berthold Leibinger Zukunftspreis for Applied Laser Technology[10] 2008: Fellow of the American Academy of Arts and Sciences 2007: Willis E. Lamb Award for Laser Sciences and Quantum Optics[11] 2006: Fellow of Biophysical Society 2006: Fellow of the American Association for the Advancement of Science 2004: NIH Director's Pioneer Award[12] 2003: Raymond and Beverly Sackler Prize in the Physical Sciences 1996: Coblentz Award Selected Literature Single-Cell Genomics Tan, Longzhi; Xie, X. Sunney "A Near-complete Spatial Map of Olfactory Receptors in the Mouse Main Olfactory Epithelium," Chem Senses 43(6), 427-432. Xu, Juanjuan; Fang, Rui; Chen, Li; Chen, Daozhen; Xiao, Jian-Ping; Yang, Weimin; Wang, Honghua; Song, Xiaoqing; Ma, Ting; Bo, Shiping; Shi, Chong; Ren, Jun; Huang, Lei; Cai, Li-Yi; Yao, Bing; Xie, X Sunney; Lu, Sijia "Noninvasive chromosome screening of human embryos by genome sequencing of embryo culture medium for in vitro fertilization," Proc Natl Acad Sci USA 113(42), 11907-11912. Chen, Chongyi; Xing, Dong; Tan, Longzhi; Li, Heng; Zhou, Guangyu; Huang, Lei; Xie, X. Sunney (2017). "Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI)" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538131). Science. 356: 189–194. Bibcode:2017Sci...356..189C (https://ui.adsabs.harvard.edu/abs/2017Sci...356..189 C). doi:10.1126/science.aak9787 (https://doi.org/10.1126%2Fscience.aak9787). PMC 5538131 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538131). Yan, Liying; Huang, Lei; Xu, Liya; Huang, Jin; Ma, Fei; Zhu, Xiaohui; Tang, Yaqiong; Liu, Mingshan; Lian, Ying; Liu, Ping; Li, Rong; Lu, Sijia; Tang, Fuchou; Qiao, Jie; Xie, X Sunney (2015). "Live births after simultaneous avoidance of monogenic diseases and chromosome abnormality by next-generation sequencing with linkage analyses" (https://www.ncbi.nlm.nih. gov/pmc/articles/PMC4702982). Proc Natl Acad Sci USA. 112 (52): 15964–15969. Bibcode:2015PNAS..11215964Y (https://ui.adsabs.harvard.edu/abs/2015PNAS..11215964Y). doi:10.1073/pnas.1523297113 (https://doi.org/10.1073%2Fpnas.1523297113). PMC 4702982 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702982). Hou, Yu; Fan, Wei; Yan, Liying; Li, Rong; Lian, Ying; Huang, Jin; Li, Jinsen; Xu, Liya; Tang, Fuchou; Xie, X. Sunney; Qiao, Jie (2013). "Genome Analyses of Single Human Oocytes". Cell. 155: 1492–1506. doi:10.1016/j.cell.2013.11.040 (https://doi.org/10.1016%2Fj.cell.2013.11.04 0). Zong, Chenghang; Lu, Sijia; Chapman, Alec R.; Xie, X. Sunney (2012). "Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell" (https://w ww.ncbi.nlm.nih.gov/pmc/articles/PMC3600412). Science. 338: 1622–1626. Bibcode:2012Sci...338.1622Z (https://ui.adsabs.harvard.edu/abs/2012Sci...338.1622Z). doi:10.1126/science.1229164 (https://doi.org/10.1126%2Fscience.1229164). PMC 3600412 (h ttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600412). 3 of 7 11/26/19, 2:15 AM Xiaoliang Sunney Xie - Wikipedia https://en.wikipedia.org/wiki/Xiaoliang_Sunney_Xie Gene Expression and Regulation Chong, Shasha; Chen, Chongyi; Ge, Hao; Sunney, Xie X. (2014). "Mechanism of Transcriptional Bursting in Bacteria". Cell. 158: 314–326. doi:10.1016/j.cell.2014.05.038 (http s://doi.org/10.1016%2Fj.cell.2014.05.038). Taniguchi, Yuichi; Choi, Paul J.; Li, Gene-Wei; Chen, Huiyi; Babu, Mohan; Hearn, Jeremy; Emili, Andrew; Xie, X. Sunney (2010). "Quantifying E. coli Proteome and Transcriptome with Single- Molecule Sensitivity in Single Cells" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922915). Science. 329: 533–538. Bibcode:2010Sci...329..533T (https://ui.adsabs.harvard.edu/abs/2010 Sci...329..533T). doi:10.1126/science.1188308 (https://doi.org/10.1126%2Fscience.1188308). PMC 2922915 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922915). Choi, Paul J.; Cai, Long; Frieda, Kirsten; Xie, X. Sunney (2008). "A Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell" (https://www.ncbi.nlm.nih.gov/pmc/art icles/PMC2819113). Science. 322: 442–446. Bibcode:2008Sci...322..442C (https://ui.adsabs.h arvard.edu/abs/2008Sci...322..442C). doi:10.1126/science.1161427 (https://doi.org/10.1126% 2Fscience.1161427). PMC 2819113 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819113). Elf, Johan; Li, Gene-Wei; Xie, X. Sunney (2007). "Probing Transcription Factor Dynamics at the Single-Molecule Level in a Living Cell" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC285389 8). Science. 316: 1191–1194. Bibcode:2007Sci...316.1191E (https://ui.adsabs.harvard.edu/ab s/2007Sci...316.1191E). doi:10.1126/science.1141967 (https://doi.org/10.1126%2Fscience.11 41967). PMC 2853898 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853898). Yu, Ji; Xiao, Jie; Ren, Xiaojia; Lao, Kaiqin; Xie, X. Sunney (2006). "Probing Gene Expression in Live Cells, One Protein Molecule at a Time". Science. 311: 1600–1603. Bibcode:2006Sci...311.1600Y (https://ui.adsabs.harvard.edu/abs/2006Sci...311.1600Y). doi:10.1126/science.1119623 (https://doi.org/10.1126%2Fscience.1119623). Cai, Long; Friedman, Nir; Xie, X. Sunney (2006). "Stochastic Protein Expression in Individual Cells at the Single Molecule Level". Nature. 440: 358–362. Bibcode:2006Natur.440..358C
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