Xiaoliang Sunney Xie - Wikipedia

Xiaoliang Sunney Xie - Wikipedia https://en.wikipedia.org/wiki/Xiaoliang_Sunney_Xie

Xiaoliang Sunney Xie

Xiaoliang Sunney Xie (Chinese: 谢晓�; born 1962 in Beijing, China) is Xiaoliang Sunney Xie an American biochemist, considered a founding father of single-molecule biophysical chemistry and single-molecule enzymology.[2]

Contents Early life Research Honors and awards Selected Literature Single-Cell Genomics Gene Expression and Regulation Single Molecule Enzymology Coherent Raman Imaging Born June 24, 1962 Single Molecule Imaging Beijing, China References Education BSc in External links Chemistry from Peking University Early life PhD in Physical Chemistry from He received his B.Sc. in Chemistry from Peking University in 1984, and UC San Diego his Ph.D. in Physical Chemistry in 1990 from University of California at Known for Single Molecule San Diego. After a brief postdoctoral appointment at University of Enzymology, Chicago, he joined Pacific Northwest National Laboratory, where he rose Coherent from Senior Research Scientist to Chief Scientist. In 1998, he became the Raman first tenured professor at Harvard University among Chinese Scholars who Imaging, came to the United States since Chinese economic reform. Single Cell Genomics Research Awards Albany Prize in He had been the Mallinckrodt Professor of Chemistry and Chemical Medicine and Biology at Harvard University until 2018, when he became the Lee Shau- Biomedical kee Professor of Peking University. Currently, he is also the Director of Research 2015, Biomedical Pioneering Innovation Center (BIOPIC), and the Director of Peter Debye Beijing Advanced Innovation Center for Genomics (ICG), both at Peking Award in

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University. Physical Chemistry As a pioneer of single-molecule biophysical chemistry, coherent Raman 2015, scattering microscopy, and single-cell genomics, he made major Ellis R. contributions to the emergence of these fields. Furthermore, he has made Lippincott significant advances on medical applications of label-free optical imaging Award 2013, and single-cell genomics. In particular, his inventions in single-cell Biophysical genomics have been used in in vitro fertilization to benefit hundreds of Society couples in China by avoiding the transmission of monogenic diseases to Founders Award their newborns. 2012 As of Jan 2019, Xie has published over 226 papers. More than forty of his NAS 2011 students and post-doctorates have become professors at major universities NAM 2016 around the world, and two are co-founders of start-up companies. CAS 2017 Professor Xie’s current research interests include the following scientific, Scientific career technological, and medical areas: Fields Biophysical Chemistry, Scientific: Single-molecule enzymology, Single- molecule biophysical chemistry, Gene expression and Optical regulation, Epigenetics, Mechanism of cell Imaging, differentiation and reprogramming, Chromosome Genomics structure and dynamics, and Genomic instability; Technological: Single-molecule imaging, Single-cell Institutions Harvard genomics, Coherent Raman scattering microscopy, DNA University sequencing; Peking Medical: Preimplantation genetic testing in in vitro University fertilization, and Early cancer diagnosis Doctoral John Douglas [1] Honors and awards advisor Simon

Qiu Shi Outstanding Scientist Award, Qiu Shi Science & Technologies Foundation (2017)[3] 2017, Foreign member of the Chinese Academy of Sciences[4] 2016: Member of the National Academy of Medicine[5] 2015: Albany Medical Center Prize[6] 2015: Peter Debye Award in Physical Chemistry, American Chemical Society[7] 2014: Fellow of the Optical Society of America 2013: NIH Director's Pioneer Award[8] 2013: Ellis R. Lippincott Award, Optical Society of America and Society for Applied Spectroscopy[9] 2012: Edward Mack, Jr. Lecture, OSU 2012: Harrison Howe Award, Rochester Section of the American Chemical Society (http://ww w.chem.rochester.edu/howe/current.php) 2012: Fellow of the American Academy of Microbiology 2012: Biophysical Society Founders Award 2011: Member of the National Academy of Sciences

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2009: Ernest Orlando Lawrence Award 2008: Fellow of the American Physical Society 2008: Berthold Leibinger Zukunftspreis for Applied Laser Technology[10] 2008: Fellow of the American Academy of Arts and Sciences 2007: Willis E. Lamb Award for Laser Sciences and Quantum Optics[11] 2006: Fellow of Biophysical Society 2006: Fellow of the American Association for the Advancement of Science 2004: NIH Director's Pioneer Award[12] 2003: Raymond and Beverly Sackler Prize in the Physical Sciences 1996: Coblentz Award

Selected Literature

Single-Cell Genomics

Tan, Longzhi; Xie, X. Sunney "A Near-complete Spatial Map of Olfactory Receptors in the Mouse Main Olfactory Epithelium," Chem Senses 43(6), 427-432. Xu, Juanjuan; Fang, Rui; Chen, Li; Chen, Daozhen; Xiao, Jian-Ping; Yang, Weimin; Wang, Honghua; Song, Xiaoqing; Ma, Ting; Bo, Shiping; Shi, Chong; Ren, Jun; Huang, Lei; Cai, Li-Yi; Yao, Bing; Xie, X Sunney; Lu, Sijia "Noninvasive chromosome screening of human embryos by genome sequencing of embryo culture medium for in vitro fertilization," Proc Natl Acad Sci USA 113(42), 11907-11912. Chen, Chongyi; Xing, Dong; Tan, Longzhi; Li, Heng; Zhou, Guangyu; Huang, Lei; Xie, X. Sunney (2017). "Single-cell whole-genome analyses by Linear Ampliﬁcation via Transposon Insertion (LIANTI)" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538131). Science. 356: 189–194. Bibcode:2017Sci...356..189C (https://ui.adsabs.harvard.edu/abs/2017Sci...356..189 C). doi:10.1126/science.aak9787 (https://doi.org/10.1126%2Fscience.aak9787). PMC 5538131 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538131). Yan, Liying; Huang, Lei; Xu, Liya; Huang, Jin; Ma, Fei; Zhu, Xiaohui; Tang, Yaqiong; Liu, Mingshan; Lian, Ying; Liu, Ping; Li, Rong; Lu, Sijia; Tang, Fuchou; Qiao, Jie; Xie, X Sunney (2015). "Live births after simultaneous avoidance of monogenic diseases and chromosome abnormality by next-generation sequencing with linkage analyses" (https://www.ncbi.nlm.nih. gov/pmc/articles/PMC4702982). Proc Natl Acad Sci USA. 112 (52): 15964–15969. Bibcode:2015PNAS..11215964Y (https://ui.adsabs.harvard.edu/abs/2015PNAS..11215964Y). doi:10.1073/pnas.1523297113 (https://doi.org/10.1073%2Fpnas.1523297113). PMC 4702982 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702982). Hou, Yu; Fan, Wei; Yan, Liying; Li, Rong; Lian, Ying; Huang, Jin; Li, Jinsen; Xu, Liya; Tang, Fuchou; Xie, X. Sunney; Qiao, Jie (2013). "Genome Analyses of Single Human Oocytes". Cell. 155: 1492–1506. doi:10.1016/j.cell.2013.11.040 (https://doi.org/10.1016%2Fj.cell.2013.11.04 0). Zong, Chenghang; Lu, Sijia; Chapman, Alec R.; Xie, X. Sunney (2012). "Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell" (https://w ww.ncbi.nlm.nih.gov/pmc/articles/PMC3600412). Science. 338: 1622–1626. Bibcode:2012Sci...338.1622Z (https://ui.adsabs.harvard.edu/abs/2012Sci...338.1622Z). doi:10.1126/science.1229164 (https://doi.org/10.1126%2Fscience.1229164). PMC 3600412 (h ttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600412).

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Gene Expression and Regulation

Chong, Shasha; Chen, Chongyi; Ge, Hao; Sunney, Xie X. (2014). "Mechanism of Transcriptional Bursting in Bacteria". Cell. 158: 314–326. doi:10.1016/j.cell.2014.05.038 (http s://doi.org/10.1016%2Fj.cell.2014.05.038). Taniguchi, Yuichi; Choi, Paul J.; Li, Gene-Wei; Chen, Huiyi; Babu, Mohan; Hearn, Jeremy; Emili, Andrew; Xie, X. Sunney (2010). "Quantifying E. coli Proteome and Transcriptome with Single- Molecule Sensitivity in Single Cells" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922915). Science. 329: 533–538. Bibcode:2010Sci...329..533T (https://ui.adsabs.harvard.edu/abs/2010 Sci...329..533T). doi:10.1126/science.1188308 (https://doi.org/10.1126%2Fscience.1188308). PMC 2922915 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922915). Choi, Paul J.; Cai, Long; Frieda, Kirsten; Xie, X. Sunney (2008). "A Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell" (https://www.ncbi.nlm.nih.gov/pmc/art icles/PMC2819113). Science. 322: 442–446. Bibcode:2008Sci...322..442C (https://ui.adsabs.h arvard.edu/abs/2008Sci...322..442C). doi:10.1126/science.1161427 (https://doi.org/10.1126% 2Fscience.1161427). PMC 2819113 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819113). Elf, Johan; Li, Gene-Wei; Xie, X. Sunney (2007). "Probing Transcription Factor Dynamics at the Single-Molecule Level in a Living Cell" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC285389 8). Science. 316: 1191–1194. Bibcode:2007Sci...316.1191E (https://ui.adsabs.harvard.edu/ab s/2007Sci...316.1191E). doi:10.1126/science.1141967 (https://doi.org/10.1126%2Fscience.11 41967). PMC 2853898 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853898). Yu, Ji; Xiao, Jie; Ren, Xiaojia; Lao, Kaiqin; Xie, X. Sunney (2006). "Probing Gene Expression in Live Cells, One Protein Molecule at a Time". Science. 311: 1600–1603. Bibcode:2006Sci...311.1600Y (https://ui.adsabs.harvard.edu/abs/2006Sci...311.1600Y). doi:10.1126/science.1119623 (https://doi.org/10.1126%2Fscience.1119623). Cai, Long; Friedman, Nir; Xie, X. Sunney (2006). "Stochastic Protein Expression in Individual Cells at the Single Molecule Level". Nature. 440: 358–362. Bibcode:2006Natur.440..358C (htt ps://ui.adsabs.harvard.edu/abs/2006Natur.440..358C). doi:10.1038/nature04599 (https://doi.o rg/10.1038%2Fnature04599).

Single Molecule Enzymology

Chong, Shasha; Chen, Chongyi; Ge, Hao; Sunney, Xie X. (2014). "Mechanism of Transcriptional Bursting in Bacteria". Cell. 158: 314–326. doi:10.1016/j.cell.2014.05.038 (http s://doi.org/10.1016%2Fj.cell.2014.05.038). Kim, Sangjin; Broströmer, Erik; Xing, Dong; Jin, Jianshi; Chong, Shasha; Ge, Hao; Wang, Siyuan; Gu, Chan; Yang, Lijiang; Gao, Yiqin; Su, Xiao-dong; Sun, Yujie; Xie, X. Sunney (2013). "Probing Allostery Through DNA" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586787). Science. 339: 816–819. Bibcode:2013Sci...339..816K (https://ui.adsabs.harvard.edu/abs/2013 Sci...339..816K). doi:10.1126/science.1229223 (https://doi.org/10.1126%2Fscience.1229223). PMC 3586787 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586787). English, Brian P.; Min, Wei; van Oijen, Antoine M.; Lee, Kang Taek; Luo, Guobin; Sun, Hongye; Cherayil, Binny J.; Kou, S.C.; Xie, X. Sunney (2006). "Ever-Fluctuating Single Enzyme Molecules: Michaelis-Menten Equation Revisited". Nat Chem Biol. 2: 87–94. Yang, Haw; Luo, Guobin; Karnchanaphanurach, Pallop; Louie, Tai-Man; Rech, Ivan; Cova, Sergio; Xun, Luying; Xie, X. Sunney (2003). "Protein Conformational Dynamics Probed by Single-Molecule Electron Transfer". Science. 302: 262–266. Bibcode:2003Sci...302..262Y (http s://ui.adsabs.harvard.edu/abs/2003Sci...302..262Y). doi:10.1126/science.1086911 (https://doi. org/10.1126%2Fscience.1086911). Lu, H. Peter; Xun, Luying; Xie, X. Sunney (1998). "Single-Molecule Enzymatic Dynamics". Science. 282: 1877–1882. doi:10.1126/science.282.5395.1877 (https://doi.org/10.1126%2Fsc

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ience.282.5395.1877).

Coherent Raman Imaging

Ji, Minbiao; Orringer, Daniel A.; Freudiger, Christian W.; Ramkissoon, Shakti; Liu, Xiaohui; Lau, Darryl; Golby, Alexandra J.; Norton, Isaiah; Hayashi, Marika; Agar, Nathalie Y. R.; Young, Geoﬀrey S.; Spino, Cathie; Santagata, Sandro; Camelo-Piragua, Sandra; Ligon, Keith L.; Sagher, Oren; Xie, X. Sunney (2013). "Rapid, Label-Free Detection of Brain Tumors with Stimulated Raman Scattering Microscopy". Science Translational Medicine. 5: 201. doi:10.1126/scitranslmed.3005954 (https://doi.org/10.1126%2Fscitranslmed.3005954). Wang, Meng C.; Min, Wei; Freudiger, Christian W.; Ruvkun, Gary; Xie, X. Sunney (2011). "RNAi Screening for Fat Regulatory Genes with SRS Microscopy" (https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC3061290). Nat Methods. 8: 135–138. doi:10.1038/nmeth.1556 (https://doi.org/10. 1038%2Fnmeth.1556). PMC 3061290 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC306129 0). Saar, Brian G.; Freudiger, Christian W.; Reichman, Jay; Stanley, C. Michael; Holtom, Gary R.; Xie, X. Sunney (2010). "Video-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering". Science. 330: 1368–1370. Bibcode:2010Sci...330.1368S (https://ui.adsabs.harvar d.edu/abs/2010Sci...330.1368S). doi:10.1126/science.1197236 (https://doi.org/10.1126%2Fsc ience.1197236). Freudiger, Christian W.; Min, Wei; Saar, Brian G.; Lu, Sijia; Holtom, Gary R.; He, Chengwei; Tsai, Jason C.; Kang, Jing X.; Xie, X. Sunney (2008). "Label-Free Biomedical Imaging with High sensitivity by Stimulated Raman Scattering Microscopy". Science. 322: 1857–1860. Bibcode:2008Sci...322.1857F (https://ui.adsabs.harvard.edu/abs/2008Sci...322.1857F). doi:10.1126/science.1165758 (https://doi.org/10.1126%2Fscience.1165758). Evans, Conor L.; Potma, Eric O.; Puoris'Haag, Mehron; Côté, Daniel; Lin, Charles P.; Xie, X. Sunney (2005). "Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283840). Proc. Natl. Acad. Sci. 102: 16807–16812. Bibcode:2005PNAS..10216807E (https://ui.adsabs.h arvard.edu/abs/2005PNAS..10216807E). doi:10.1073/pnas.0508282102 (https://doi.org/10.10 73%2Fpnas.0508282102). PMC 1283840 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC128 3840). Zumbusch, Andreas; Holtom, Gary R.; Xie, X. Sunney (1999). "Vibrational Microscopy Using Coherent Anti-Stokes Raman Scattering". Phys Rev Lett. 82: 4142–4145. Bibcode:1999PhRvL..82.4142Z (https://ui.adsabs.harvard.edu/abs/1999PhRvL..82.4142Z). doi:10.1103/physrevlett.82.4142 (https://doi.org/10.1103%2Fphysrevlett.82.4142).

Single Molecule Imaging

Zhou, Yuexin; Wang, Ping; Tian, Feng; Gao, Ge; Huang, Lei; Wei, Wensheng; Xie, X. Sunney (2017). "Painting a speciﬁc chromosome with CRISPR/Cas9 for live-cell imaging". Cell Res. 27: 298–301. doi:10.1038/cr.2017.9 (https://doi.org/10.1038%2Fcr.2017.9). Chong, Shasha; Min, Wei; Xie, X. Sunney (2010). "Ground-State Depletion Microscopy:Detection Sensitivity of Single-Molecule Optical Absorption at Room Temperature". J Phys Chem Lett. 1: 3316–3322. doi:10.1021/jz1014289 (https://doi.org/10.1021%2Fjz10142 89). Min, Wei; Lu, Sijia; Chong, Shasha; Roy, Rahul; Holtom, Gary R.; Xie, X. Sunney (2009). "Imaging Chromophores with Undetectable Fluorescence by Stimulated Emission Microscopy". Nature. 461: 1105–1109. Bibcode:2009Natur.461.1105M (https://ui.adsabs.harv ard.edu/abs/2009Natur.461.1105M). doi:10.1038/nature08438 (https://doi.org/10.1038%2Fna

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ture08438). Sánchez, Erik J.; Novotny, Lukas; Xie, X. Sunney (1999). "Near-ﬁeld Fluorescence Microscopy Based on Two-photon Excitation with Metal Tips". Phys Rev Lett. 82: 4014–4017. Bibcode:1999PhRvL..82.4014S (https://ui.adsabs.harvard.edu/abs/1999PhRvL..82.4014S). doi:10.1103/physrevlett.82.4014 (https://doi.org/10.1103%2Fphysrevlett.82.4014). Sánchez, Erik J.; Novotny, Lukas; Holtom, G.R.; Xie, X. Sunney (1997). "Room-Temperature Fluorescence Imaging and Spectroscopy of Single Molecules by Two-Photon Excitation". J Phys Chem A. 101: 7019–7023. Bibcode:1997JPCA..101.7019S (https://ui.adsabs.harvard.edu/abs/ 1997JPCA..101.7019S). doi:10.1021/jp971915b (https://doi.org/10.1021%2Fjp971915b). Xie, X. Sunney; Dunn, Robert C. (1994). "Probing Single Molecule Dynamics". Science. 265: 361–364. Bibcode:1994Sci...265..361X (https://ui.adsabs.harvard.edu/abs/1994Sci...265..361 X). doi:10.1126/science.265.5170.361 (https://doi.org/10.1126%2Fscience.265.5170.361).

References

1. https://bernstein.harvard.edu/pages/AboutProfXie.html 2. "Sunney Xie to receive Leibinger Research Prize for laser technology" (http://physicstoday.scit ation.org/do/10.1063/PT.4.1557/full/). Physics Today. 2013. doi:10.1063/pt.4.1557 (https://doi. org/10.1063%2Fpt.4.1557). 3. http://newsen.pku.edu.cn/news_events/news/focus/6288.htm 4. "关于公布2017年中国科学院院士增选当选院士名单的公告" (http://www.cas.cn/tt/201711/t20171128 _4624789.shtml) (in Chinese). Chinese Academy of Sciences. 2017-11-28. Retrieved 2019-11-22. 5. National Academy of Medicine Elects 79 New Members (https://nam.edu/national-academy-of- medicine-elects-79-new-members/) 6. Albany Medical Center Prize (http://www.amc.edu/Academic/AlbanyPrize/Recipients/recipients _current/xie.cfm) 7. Peter Debye Award (https://www.acs.org/content/acs/en/funding-and-awards/awards/national/ bytopic/peter-debye-award-in-physical-chemistry.html) 8. NIH Director's Pioneer Award 2013 (https://commonfund.nih.gov/pioneer/Recipients13) 9. Ellis R. Lippincott Award (http://www.osa.org/en-us/awards_and_grants/awards/award_descript ion/ellislippincott/) 10. Berthold Leibinger Zukunftspreis (http://www.leibinger-stiftung.de/de/foerderaktivitaeten/laser -forschungs-innovationspreis/zukunftspreis.html) 11. Biography of Xie from the Website of the Willis E. Lamb Award (displayed June 4, 2008) (htt p://www.lambmedal.org/2007/2007-xie.html) 12. NIH Director's Pioneer Award 2004 (https://commonfund.nih.gov/pioneer/Recipients04)

External links

Homepage of the Xie Group at Harvard (http://bernstein.harvard.edu/)

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