APPENDIX B: ARV/NON-ARV Drug/Drug Interactions (POS Edits on PDL) Non-ARV Interacting Drug ARV Drug Generic Name Brand Name (Generic Name)* Generic Name (Brand Name) Fluticasone Advair Diskus & HFA (fluticasone/salmeterol) Aptivus (tipranavir) Arnuity Ellipta (fluticasone furoate) Crixivan (indinavir) Breo Ellipta (fluticasone/vilanterol) Invirase (saquinavir) Dymista (azelastine/fluticasone) Lexiva (fosamprenavir) Flonase (fluticasone) Reyataz (atazanzavir) Flovent Diskus & HFA (fluticasone) Viracept (nelfinavir mesylate) Veramyst (fluticasone) All products containing cobicistat All products containing darunavir All products containing ritonavir Phenytoin Dilantin (phenytoin) Etravirine (Intelence) Carbamazepine Tegretol (carbamazepine) Rilpivirine (Edurant) Phenobarbital Delavirdine (Rescriptor) Fostemsavir (Rukobia) Saquinavir (Invirase) All products containing cobicistat All products containing darunavir All products containing doravirine All products containing elvitegravir All products containing raltegravir All products containing rilpivirine All products containing tenofovir alafenamide Salmeterol Advair Diskus & HFA (fluticasone/salmeterol) Atazanzavir (Reyataz) Serevent Diskus (salmeterol) Fosamprenavir (Lexiva) Indinavir (Crixivan) Nelfinavir (Viracept) Saquinavir (Invirase) Tipranavir (Aptivus) All products containing cobicistat All products containing darunavir All products containing ritonavir Alfuzosin Uroxatrol Atazanzavir (Reyataz) Fosamprenavir (Lexiva) Indinavir (Crixivan) Nelfinavir (Viracept) Saquinavir (Invirase) Tipranavir (Aptivus) All products containing cobicistat All products containing darunavir All products containing ritonavir Lurasidone Latuda Atazanzavir (Reyataz) Indinavir (Crixivan) Nelfinavir (Viracept) Saquinavir (Invirase)

Last update: 9/14/20

Tipranavir (Aptivus) All products containing cobicistat All products containing darunavir All products containing ritonavir Sildenafil Revatio dosing only (for PAH) Atazanzavir (Reyataz) Fosamprenavir (Lexiva) Indinavir (Crixivan) Nelfinavir (Viracept) Saquinavir (Invirase) Tipranavir (Aptivus) All products containing cobicistat All products containing darunavir All products containing ritonavir Colchicine** Colcrys Atazanzavir (Reyataz) Fosamprenavir (Lexiva) Indinavir (Crixivan) Nelfinavir (Viracept) Saquinavir (Invirase) Tipranavir (Aptivus) All products containing cobicistat All products containing darunavir All products containing ritonavir Voriconazole Vfend Ritonavir (Norvir) ≥ 400 mg twice daily *NOTE – List of meds in center column is NOT a complete list. Any product containing the active ingredient

shown in the first column will be an interaction with the drug in the third column. **The contraindications listed with colchicine are for patients with renal or hepatic impairment.

ARV = antiretroviral; HFA = hydrofluoroalkane (propellant); PAH = pulmonary arterial hypertension; POS = point of service

Other ARV/Non-ARV drug‐drug interactions not included in this table are managed via severity level 1 DDI conflict codes, requiring pharmacist action at the POS.

Last update: 9/14/20