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Supplementary Table 2 Table S2 Potential targets of miR-9-3 in MCF-7 cells Mean of Intensities Ratio Gene Symbol Human Gene Description Ctrl miR-9 miR-9* miR-9/Ctrl miR-9*/Ctrl FBXW2 F-box and WD repeat domain containing 2 109.61 502.26 513.97 4.58 4.69 FAM62A family with sequence similarity 62, member A 65.28 287.19 245.59 4.40 3.76 SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium) 87.12 333.06 343.35 3.82 3.94 KLHDC5 kelch domain containing 5 99.92 344.30 420.00 3.45 4.20 CC2D1B coiled-coil and C2 domain containing 1B 296.83 1013.51 988.06 3.41 3.33 GPAM glycerol-3-phosphate acyltransferase, mitochondrial 87.09 286.46 278.41 3.29 3.20 CUL4A cullin 4A 47.99 155.16 200.94 3.23 4.19 SMC1A structural maintenance of chromosomes 1A 126.43 403.56 465.37 3.19 3.68 CACNB2 calcium channel, voltage-dependent, beta 2 subunit 87.11 266.88 279.56 3.06 3.21 SLC6A6 solute carrier family 6, member 6 137.27 414.29 447.48 3.02 3.26 SEC31A SEC31 homolog A (S. cerevisiae) 79.11 234.96 280.71 2.97 3.55 PTBP2 polypyrimidine tract binding protein 2 495.58 1437.74 1282.95 2.90 2.59 C3orf58 chromosome 3 open reading frame 58 62.72 175.93 152.28 2.80 2.43 HIC2 hypermethylated in cancer 2 157.64 427.84 447.94 2.71 2.84 KIAA0562 KIAA0562 73.31 195.78 213.59 2.67 2.91 LPP LIM domain containing preferred translocation partner in lipoma 60.87 161.90 184.81 2.66 3.04 FNIP1 folliculin interacting protein 1 161.56 421.82 464.73 2.61 2.88 TFRC transferrin receptor (p90, CD71) 95.11 244.87 284.62 2.57 2.99 RNF111 ring finger protein 111 44.75 112.69 131.59 2.52 2.94 USP31 ubiquitin specific peptidase 31 36.90 90.42 102.07 2.45 2.77 WAPAL wings apart-like homolog (Drosophila) 103.35 252.11 311.97 2.44 3.02 SCUBE3 signal peptide, CUB domain, EGF-like 3 147.84 355.80 363.63 2.41 2.46 RYBP RING1 and YY1 binding protein 130.24 313.22 349.00 2.41 2.68 CHMP2B chromatin modifying protein 2B 81.34 191.12 149.82 2.35 1.84 XRN1 5'-3' exoribonuclease 1 147.99 343.69 310.95 2.32 2.10 EDEM3 ER degradation enhancer, mannosidase alpha-like 3 96.43 222.88 232.59 2.31 2.41 UBFD1 ubiquitin family domain containing 1 113.32 260.1644 283.53 2.30 2.50 HISPPD1 histidine acid phosphatase domain containing 1 686.22 1574.70 1650.60 2.29 2.41 OTUD7B OTU domain containing 7B 264.17 606.20 656.46 2.29 2.48 CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 255.97 585.90 561.72 2.29 2.19 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4- P4HA2 hydroxylase), alpha polypeptide II 383.77 873.96 882.71 2.28 2.30 UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast) 118.17 268.92 381.61 2.28 3.23 Mean of Intensities Ratio Gene Symbol Human Gene Description Ctrl miR-9 miR-9* miR-9/Ctrl miR-9*/Ctrl CXCR4 chemokine (C-X-C motif) receptor 4 265.14 601.60 617.30 2.27 2.33 SLC5A3 solute carrier family 5 (inositol transporters), member 3 160.68 360.18 347.68 2.24 2.16 TNS1 tensin 1 158.49 354.03 402.56 2.23 2.54 INSIG1 insulin induced gene 1 172.13 384.44 435.41 2.23 2.53 SFRS10 splicing factor, arginine/serine-rich 10 324.46 724.32 738.98 2.23 2.28 KLHL24 kelch-like 24 (Drosophila) 82.12 181.47 209.02 2.21 2.55 GOSR1 golgi SNAP receptor complex member 1 366.16 807.90 903.67 2.21 2.47 SERTAD2 SERTA domain containing 2 228.98 501.23 522.15 2.19 2.28 BAG4 BCL2-associated athanogene 4 183.07 398.81 506.31 2.18 2.77 BTG2 BTG family, member 2 97.41 210.07 254.86 2.16 2.62 LUC7L2 LUC7-like 2 (S. cerevisiae) 130.51 280.00 330.32 2.15 2.53 FRYL FRY-like 293.71 625.75 648.57 2.13 2.21 ATXN3 ataxin 3 126.73 269.86 306.45 2.13 2.42 SIRT1 sirtuin (silent mating type information regulation 2 homolog) 1 110.38 234.39 250.82 2.12 2.27 OTUD4 OTU domain containing 4 177.30 372.28 394.83 2.10 2.23 PHF20L1 PHD finger protein 20-like 1 94.50 197.86 198.58 2.09 2.10 STC1 stanniocalcin 1 148.04 309.27 357.26 2.09 2.41 PHTF2 putative homeodomain transcription factor 2 474.65 991.42 1015.85 2.09 2.14 DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 130.55 270.21 325.06 2.07 2.49 C18orf25 chromosome 18 open reading frame 25 74.92 154.23 169.27 2.06 2.26 C14orf147 chromosome 14 open reading frame 147 62.55 128.22 140.49 2.05 2.25 GLCCI1 glucocorticoid induced transcript 1 1023.73 2094.65 2122.47 2.05 2.07 CREBZF CREB/ATF bZIP transcription factor 434.01 883.84 910.71 2.04 2.10 KIAA0423 family with sequence similarity 179, member B 56.76 115.03 159.56 2.03 2.81 CLCN5 chloride channel 5 (nephrolithiasis 2, X-linked, Dent disease) 129.63 261.85 377.25 2.02 2.91 KITLG KIT ligand 83.54 167.08 199.32 2.00 2.39 C21orf91 chromosome 21 open reading frame 91 74.81 149.35 197.51 2.00 2.64 SYNJ1 synaptojanin 1 205.48 403.84 488.50 1.97 2.38 ZBTB39 zinc finger and BTB domain containing 39 60.80 117.45 126.67 1.93 2.08 SNX16 sorting nexin 16 135.00 259.99 298.78 1.93 2.21 KLHL18 kelch-like 18 (Drosophila) 273.24 516.16 690.81 1.89 2.53 PIM3 pim-3 oncogene 101.78 190.33 247.69 1.87 2.43 DENND1A DENN/MADD domain containing 1A 188.57 346.95 458.61 1.84 2.43 PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 114.36 210.26 267.85 1.84 2.34 TARDBP TAR DNA binding protein 224.29 411.98 506.43 1.84 2.26 TULP4 tubby like protein 4 80.75 144.97 190.31 1.80 2.36 Mean of Intensities Ratio Gene Symbol Human Gene Description Ctrl miR-9 miR-9* miR-9/Ctrl miR-9*/Ctrl DBT dihydrolipoamide branched chain transacylase E2 246.74 438.39 606.41 1.78 2.46 CPEB1 cytoplasmic polyadenylation element binding protein 1 456.18 711.18 815.77 1.56 1.79 ACOT7 acyl-CoA thioesterase 7 328.50 200.88 210.36 -1.64 -1.56 QKI quaking homolog, KH domain RNA binding (mouse) 551.96 319.53 350.50 -1.73 -1.57 YPEL2 yippee-like 2 (Drosophila) 1025.55 588.09 565.66 -1.74 -1.81 CPEB4 cytoplasmic polyadenylation element binding protein 4 210.70 115.92 140.37 -1.82 -1.50 PGRMC2 progesterone receptor membrane component 2 1085.25 574.70 532.72 -1.89 -2.04 FAM46A family with sequence similarity 46, member A 846.48 440.70 346.52 -1.92 -2.44 AFF1 AF4/FMR2 family, member 1 205.04 106.10 88.97 -1.93 -2.30 ZNF354A zinc finger protein 354A 582.85 286.60 272.50 -2.03 -2.14 ONECUT2 one cut homeobox 2 239.16 115.43 100.92 -2.07 -2.37 COL15A1 collagen, type XV, alpha 1 129.31 59.93 63.31 -2.16 -2.04 ATP7A ATPase, Cu++ transporting, alpha polypeptide 239.81 110.19 107.15 -2.18 -2.24 KIAA1128 KIAA1128 578.86 265.34 261.40 -2.18 -2.21 ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 940.04 420.72 483.01 -2.23 -1.95 FXR1 fragile X mental retardation, autosomal homolog 1 2254.18 1002.06 921.31 -2.25 -2.45 UHRF1 ubiquitin-like, containing PHD and RING finger domains, 1 685.20 302.26 369.51 -2.27 -1.85 ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 397.06 171.62 180.78 -2.31 -2.20 SLC31A2 solute carrier family 31 (copper transporters), member 2 112.93 47.77 52.56 -2.36 -2.15 KIAA1219 KIAA1219 492.66 206.00 193.16 -2.39 -2.55 SLC35B3 solute carrier family 35, member B3 321.60 130.42 150.05 -2.47 -2.14 ZBTB41 zinc finger and BTB domain containing 41 1033.68 417.54 407.17 -2.48 -2.54 CEP350 centrosomal protein 350kDa 706.14 278.82 309.04 -2.53 -2.28 WDR20 WD repeat domain 20 349.55 137.81 166.50 -2.54 -2.10 FOXN2 forkhead box N2 413.52 153.87 243.98 -2.69 -1.69 RANBP2 RAN binding protein 2 599.96 213.25 206.31 -2.81 -2.91 NAP1L1 nucleosome assembly protein 1-like 1 197.15 64.49 63.25 -3.06 -3.12 UBR1 ubiquitin protein ligase E3 component n-recognin 1 1044.60 337.64 413.80 -3.09 -2.52 BCL6 B-cell CLL/lymphoma 6 (zinc finger protein 51) 2065.33 657.28 572.57 -3.14 -3.61 MGA MAX gene associated 497.74 146.81 149.06 -3.39 -3.34 BAZ2B bromodomain adjacent to zinc finger domain, 2B 2270.59 651.76 610.66 -3.48 -3.72 MIER3 mesoderm induction early response 1, family member 3 310.61 85.86 82.33 -3.62 -3.77 AP1S2 adaptor-related protein complex 1, sigma 2 subunit 202.07 55.07 57.46 -3.67 -3.52 MBNL1 muscleblind-like (Drosophila) 369.53 48.84 42.39 -7.57 -8.72 .
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