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Journal of Dental Research Journal of Dental Research http://jdr.sagepub.com/ Silver Diamine Fluoride: A Caries ''Silver-Fluoride Bullet'' A. Rosenblatt, T.C.M. Stamford and R. Niederman J DENT RES 2009 88: 116 DOI: 10.1177/0022034508329406 The online version of this article can be found at: http://jdr.sagepub.com/content/88/2/116 Published by: http://www.sagepublications.com On behalf of: International and American Associations for Dental Research Additional services and information for Journal of Dental Research can be found at: Email Alerts: http://jdr.sagepub.com/cgi/alerts Subscriptions: http://jdr.sagepub.com/subscriptions Reprints: http://www.sagepub.com/journalsReprints.nav Permissions: http://www.sagepub.com/journalsPermissions.nav >> Version of Record - Mar 5, 2009 What is This? Downloaded from jdr.sagepub.com at UNIV OF KENTUCKY LEXINGTON on February 12, 2013 For personal use only. No other uses without permission. © 2009 International & American Associations for Dental Research CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE A. Rosenblatt1*,2, 3, T.C.M. Stamford3, and R. Niederman1,4 Silver Diamine Fluoride: 1The Forsyth Institute, 140 The Fenway, Boston, MA 02115, A Caries “Silver-Fluoride Bullet” USA; 2Children’s Hospital Medical Center, Boston, MA USA; 3School of Dentistry, University of Pernambuco, Recife, Pernambuco, Brazil; and 4Goldman School of Dental Medicine, Boston University, Boston, MA, USA; *corresponding author, [email protected] J Dent Res 88(2):116-125, 2009 ABSTRACT The antimicrobial use of silver compounds pivots on the 100-year-old application of silver nitrate, silver foil, and INTRODUCTION silver sutures for the prevention and treatment of ocular, ith a wealth of fluoride-based caries-preventive agents (Table 1), why + surgical, and dental infections. Ag kills pathogenic W might one be interested in yet another fluoride delivery system? The organisms at concentrations of < 50 ppm, and current/ answer lies in silver diamine fluoride’s (SDF) hypothesized ability to halt the potential anti-infective applications include: acute burn caries process and simultaneously prevent the formation of new caries. This coverings, catheter linings, water purification systems, hypothesized ability is thought to derive from the combined effects of: silver- hospital gowns, and caries prevention. To distill the cur- rent best evidence relative to caries, this systematic salt-stimulated sclerotic or calcified dentin formation (e.g., Stebbins, 1891), review asked: Will silver diamine fluoride (SDF) more silver nitrate’s potent germicidal effect (e.g., Miller, 1905; Howe, 1917; Klein effectively prevent caries than fluoride varnish? A five- and Knutson, 1942), and fluoride’s ability to reduce decay (e.g., Marinho database search, reference review, and hand search et al., 2002, 2004a,b). [Dentists termed silver nitrate “Howe’s solution” after identified 99 human clinical trials in three languages Percy Howe, who reported on its use for caries prevention. Howe was The published between 1966 and 2006. Dual review for Forsyth Institute’s first research director, and the Forsyth library is named controlled clinical trials with the patient as the unit of after him.] The specific interest in SDF centers around its 5 presumed attri- observation, and excluding cross-sectional, animal, butes (Bedi and Sardo-Infirri, 1999): control of pain and infection, ease and in vitro studies, and opinions, identified 2 studies meet- simplicity of use (paint on), affordability of material (pennies per application), ing the inclusion criteria. The trials indicated that SDF’s minimal requirement for personnel time and training (one minute, once per lowest prevented fractions for caries arrest and caries year), and the fact that it is non-invasive. In this sense, SDF has the potentially prevention were 96.1% and 70.3%, respectively. In unique ability to be a “silver-fluoride bullet,” simultaneously halting the car- contrast, fluoride varnish’s highest prevented fractions iogenic process and preventing caries. for caries arrest and caries prevention were 21.3% and The need for agents like SDF is perhaps best understood in terms of the 55.7%, respectively. Similarly, SDF’s highest numbers World Health Organization (WHO) Millennium Development Goals for Health needed to treat for caries arrest and caries prevention were 0.8 (95% CI = 0.5-1.0) and 0.9 (95% CI = 0.4- (Wagstaff and Claeson, 2004), and in particular the oral health goals (Hobdell 1.1), respectively. For fluoride varnish, the lowest num- et al., 2003). The proposed path to achieving these goals is the provision of a bers needed to treat for caries arrest and prevention were basic oral health package, consisting of: emergency care, prevention, and cost- 3.7 (95% CI = 3.4-3.9) and 1.1 (95% CI = 0.7-1.4), effective interventions, in that order (Frencken et al., 2008). To achieve these respectively. Adverse events were monitored, with no goals, the use of simple technologies will be required for ‘scale up’ to improve significant differences between control and experimen- access to oral health care at a much lower cost. At the same time, all of these tal groups. These promising results suggest that SDF is preventive interventions will need to be built upon a firm evidence base. more effective than fluoride varnish, and may be a valu- With the continuing population expansion, and the decreasing availability able caries-preventive intervention. As well, the avail- of dentists to provide emergency care and restorative treatment, the likeliest ability of a safe, effective, efficient, and equitable path to oral health will be an intense focus on prevention. Silver fluoride caries-preventive agent appears to meet the criteria of compounds may partially fill this need. both the WHO Millennium Goals and the US Institute of Medicine’s criteria for 21st century medical care. Brief History systematic review, caries, pre- KEY WORDS: The first medicinal use for silver appears to have been around 1000 BC for vention, fluoride, silver. the storing of potable water (see Russell and Hugo, 1994). Current uses of DOI: 10.1177/0022034508329406 silver compounds in medicine revolve around the application of silver nitrate, Received August 2, 2007; Last revision September 25, 2008; silver foil, and silver sutures for the prevention of ocular and surgical infec- Accepted October 1, 2008 tions (e.g., Credé, 1881; Halsted, 1895). Von Naegeli (1893) demonstrated A supplemental appendix to this article is published elec- that silver can kill spirogyra, and found that various forms of silver have dif- tronically only at http://jdr.sagepub.com/supplemental. ferent effects, with silver nitrate being a very effective antimicrobial agent. 116 Downloaded from jdr.sagepub.com at UNIV OF KENTUCKY LEXINGTON on February 12, 2013 For personal use only. No other uses without permission. © 2009 International & American Associations for Dental Research J Dent Res 88(2) 2009 Silver Diamine Fluoride 117 Table 1. Fluoride Efficacy in Preventing Caries Fluoride Estimated Delivery System Caries Reduction Reference Milk ? Yeung et al. (2005) Salt 15% Marthaler and Petersen (2005) Toothpaste 24% Marinho et al. (2004a) Mouthwash 26% Marinho et al. (2004b) Water (adults) 27% Griffin et al. (2007) Gel (children) 28% Marinho et al. (2002) Water (children) 34% Do and Spencer (2007) Figure 1. Clinical photographs prior to and following application of Varnish 46% Marinho et al. (2002) silver diamine fluoride. (A) Clinical photographs of interproximal SDF permanent teeth > 60% Current review caries lesions in maxillary incisors of a 5-year-old girl. (B) Clinical SDF deciduous teeth > 70% Current review photograph of brown staining following a 60-second application of Cariestop® 12% silver diamine fluoride. Note that only the caries lesion, not the tooth, is stained. Table 2. Effects of Silver Nitrate and Silver Scraps on Decay Prevention (Stebbins, 1891) Year after Partial (Green, 1989, using AgF + SnF2). These early studies led to the use Treatment # Teeth Success* Success Unsuccessful of silver diamine fluoride in Australia (Gotjamanos, 1997), Japan (Yamaga and Yokomizo, 1969), and Mexico (Aron, 1995). 1 64 37 (58%) 17 (27%) 13 (20%) While the preliminary studies of silver fluoride demonstrated an 2 27 10 (37%) 5 (19%) 12 (44%) anti-caries effect, they also recognized that silver fluoride can 3 142 87 (61%) 33 (23%) 22 (15%) blacken caries lesions (but not sound tooth surfaces) (Fig. 1). * Success = no further decay; Partial success = expansion of decay; Unsuccessful Therefore, newer in vitro experiments are examining silver fluoride = no silver discoloration. followed by potassium iodide (Knight et al., 2006), which produces a white silver iodide reaction product. However, the ability of this product to prevent caries in vivo has not yet been demonstrated. From a dental perspective, Stebbins (1891) reported that teeth Mechanisms of Action restored with amalgam displayed black surfaces where the prog- ress of decay had ceased. Then, reasoning from the current use Soft Lewis acids, like the transition metal silver, have high polar- of silver nitrate treatment for sensitive teeth, and the resulting izing power (a large ratio of ionic charge to the radius of the ion) tooth coloration, he mixed nitric acid with amalgam scraps and and typically form strong bonds with soft Lewis bases. These applied them to caries lesions in 35 children. Stebbins’ results include sulfur and nitrogen ligands such as cysteine and histidine suggest that this treatment successfully inhibited decay in 61% residues in proteins. As indicated below, these interactions may of cases at 3 yrs (Table 2). Stebbins hypothesized that caries account for the effects of silver on bacteria and teeth. inhibition was the result of bacterial killing and the deposition of a “black crust,” generating a sclerotic protective coating of sec- Bacteria ondary dentin. Subsequently, Howe (1917) directly applied sil- ver nitrate to caries lesions with similar results. “Howe’s solution” Multiple modes of action have been proposed for silver (e.g., was used for this purpose for the next 50 yrs. Lansdown, 2002a, 2006; Wu et al., 2007).
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