CDH16 Recombinant Monoclonal Antibody, Clone CDH16/1532R

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CDH16 Recombinant Monoclonal Antibody, Clone CDH16/1532R

CDH16 recombinant monoclonal Gene Alias: - antibody, clone CDH16/1532R Gene Summary: This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, Catalog Number: RAB00315 membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on Regulatory Status: For research use only (RUO) chromosome 16q22.1, the gene localizes with Product Description: Recombinant rabbit monoclonal superfamily members CDH1, CDH3, CDH5, CDH8 and antibody raised against human CDH16. CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region Clone Name: CDH16/1532R and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition Immunogen: Original antibody is raised against sequence typical of most classical cadherins. Expression recombinant protein corresponding to full length human is exclusively in kidney, where the protein functions as CDH16. the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue Theoretical MW (kDa): 130 development. [provided by RefSeq] Reactivity: Human,Mouse,Rat References: 1. Kidney-specific cadherin, a specific marker for the Applications: Flow Cyt, IF, IHC-P distal portion of the nephron and related renal (See our web site product page for detailed applications neoplasms. Shen SS, Krishna B, Chirala R, Amato RJ, information) Truong LD. Mod Pathol. 2005 Jul;18(7):933-40. 2. Expression of kidney-specific cadherin distinguishes Protocols: See our web site at chromophobe renal cell carcinoma from renal http://www.abnova.com/support/protocols.asp or product oncocytoma. Mazal PR, Exner M, Haitel A, Krieger S, page for detailed protocols Thomson RB, Aronson PS, Susani M. Hum Pathol. 2005 Form: Liquid Jan;36(1):22-8. Purification: Protein A purification Isotype: IgG, kappa Recommend Usage: Flow Cytometry (0.5-1 ug/million cells) Immunofluorescence (1-2 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user. Storage Buffer: In 10 mM PBS (0.05% BSA and 0.05% azide). Storage Instruction: Store at 4°C. Entrez GeneID: 1014 Gene Symbol: CDH16 Page 1/1 Powered by TCPDF (www.tcpdf.org).

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Cadherin 16 (CDH16) Human Gene Knockout Kit (CRISPR) Product Data
OriGene Technologies, Inc. 9620 Medical Center Drive, Ste 200 Rockville, MD 20850, US Phone: +1-888-267-4436 [email protected] EU: [email protected] CN: [email protected] Product datasheet for KN406551 Cadherin 16 (CDH16) Human Gene Knockout Kit (CRISPR) Product data: Product Type: Knockout Kits (CRISPR) Symbol: Cadherin 16 Locus ID: 1014 Kit Components: , 10 ug , 10 ug : EF1a-GFP-P2A-Puro Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. RefSeq: NM_001204744, NM_001204745, NM_001204746, NM_004062 Summary: This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011] This product is to be used for laboratory only. Not for diagnostic or therapeutic use. View online » ©2020 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 1 / 2 Cadherin 16 (CDH16) Human Gene Knockout Kit (CRISPR) – KN406551 Product images: This product is to be used for laboratory only.
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A Computational Approach for Defining a Signature of Β-Cell Golgi Stress in Diabetes Mellitus
Page 1 of 781 Diabetes A Computational Approach for Defining a Signature of β-Cell Golgi Stress in Diabetes Mellitus Robert N. Bone1,6,7, Olufunmilola Oyebamiji2, Sayali Talware2, Sharmila Selvaraj2, Preethi Krishnan3,6, Farooq Syed1,6,7, Huanmei Wu2, Carmella Evans-Molina 1,3,4,5,6,7,8* Departments of 1Pediatrics, 3Medicine, 4Anatomy, Cell Biology & Physiology, 5Biochemistry & Molecular Biology, the 6Center for Diabetes & Metabolic Diseases, and the 7Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202; 2Department of BioHealth Informatics, Indiana University-Purdue University Indianapolis, Indianapolis, IN, 46202; 8Roudebush VA Medical Center, Indianapolis, IN 46202. *Corresponding Author(s): Carmella Evans-Molina, MD, PhD ([email protected]) Indiana University School of Medicine, 635 Barnhill Drive, MS 2031A, Indianapolis, IN 46202, Telephone: (317) 274-4145, Fax (317) 274-4107 Running Title: Golgi Stress Response in Diabetes Word Count: 4358 Number of Figures: 6 Keywords: Golgi apparatus stress, Islets, β cell, Type 1 diabetes, Type 2 diabetes 1 Diabetes Publish Ahead of Print, published online August 20, 2020 Diabetes Page 2 of 781 ABSTRACT The Golgi apparatus (GA) is an important site of insulin processing and granule maturation, but whether GA organelle dysfunction and GA stress are present in the diabetic β-cell has not been tested. We utilized an informatics-based approach to develop a transcriptional signature of β-cell GA stress using existing RNA sequencing and microarray datasets generated using human islets from donors with diabetes and islets where type 1(T1D) and type 2 diabetes (T2D) had been modeled ex vivo. To narrow our results to GA-specific genes, we applied a filter set of 1,030 genes accepted as GA associated.
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Supplementary Table 1: Adhesion Genes Data Set
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Learning from Cadherin Structures and Sequences: Affinity Determinants and Protein Architecture
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Monoclonal Antibody to Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16(Clone : CDH16/1071)
9853 Pacific Heights Blvd. Suite D. San Diego, CA 92121, USA Tel: 858-263-4982 Email: [email protected] 36-1001: Monoclonal Antibody to Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16(Clone : CDH16/1071) Clonality : Monoclonal Clone Name : CDH16/1071 Application : IHC,FACS,IF Reactivity : Human, Rat Gene : CDH16 Gene ID : 1014 Uniprot ID : O75309 Format : Purified Alternative Name : CDH16,UNQ695/PRO1340 Isotype : Mouse IgG1 Kappa Immunogen Information : Recombinant human CDH16 protein Description This MAb recognizes a protein of 130kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels.Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma. Product Info Amount : 100 µg Purification : Affinity Chromatography 100 µg in 500 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly Content : toxic. Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid Storage condition : repeated freeze and thaw cycles. Application Note Flow Cytometry (0.5-1µg/million cells in 0.1ml); Immunofluorescence (1-2µg/ml); Immunohistology (Formalin-fixed) (0.5-1µg/ml for 30 minutes at RT); (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined.
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E-Cadherin Loss Alters Cytoskeletal Organization and Adhesion in Non-Malignant Breast Cells but Is Insufficient to Induce An
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Pan-Cancer Genomic Amplifications Underlie a Wnt Hyperactivation Phenotype
bioRxiv preprint doi: https://doi.org/10.1101/519611; this version posted January 13, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 Pan-cancer genomic amplifications underlie a Wnt hyperactivation phenotype 2 associated with stem cell-like features leading to poor prognosis 3 4 5 6 Wai Hoong Chang and Alvina G. Lai 7 8 9 Nuffield Department of Medicine, University of Oxford, 10 Old Road Campus, Oxford, OX3 7FZ, United Kingdom 11 12 For correspondence: [email protected] bioRxiv preprint doi: https://doi.org/10.1101/519611; this version posted January 13, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 13 List of Abbreviations 14 TCGA The Cancer Genome Atlas KEGG Kyoto Encyclopedia of Genes and Genomes GO Gene Ontology ROC Receiver operating characteristic AUC Area under the curve HR Hazard ratio TNM Tumor, node and metastasis HIF Hypoxia inducible factor TF Transcription factor EMT Epithelial-to-mesenchymal transition 15 bioRxiv preprint doi: https://doi.org/10.1101/519611; this version posted January 13, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.
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Anti-Cadherin 16 Antibody [CDH16/1071] (ARG56181)
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Autocrine IFN Signaling Inducing Profibrotic Fibroblast Responses By
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