The 1891 London Congress of Hygiene and Demography

Total Page:16

File Type:pdf, Size:1020Kb

The 1891 London Congress of Hygiene and Demography The founders of modern microbiology the 1891 London Congress of Hygiene and Demography Piccadilly Circus, London, photographed in ca 1890. Francis Frith Collection hanks to the completion of the main European rail of executive capacity, and the apparent with the unsustainable claims he had network, scientists could, by the second half of the International scientifi c raw inexperience’. recently made for the therapeutic 19th century, easily travel to international congresses. powers of tuberculin. AtAt thethe eendnd ofof eacheach academicacademic yyearear ((whichwhich ttypicallyypically meetings are nothing new. The Bacteriological Section Generally, the bacteriologists present lasted only from October to May), professional groups, The proceedings on Hygiene of the were a youngish and dedicated brother- such as scientists, doctors, engineers and syndicalists, Philip Mortimer describesdescribes 1891 Congress were presided over by hood, many of whom were soon to Twould meet to present new work and debate matters of topi- Sir Joseph (soon to be Lord) Lister, make names for themselves in this cal interest. and the proceedings on Demography expanding scientifi c fi eld. Their facial This pattern was well established by the 1890s. The Great an early gathering of by Sir Francis Galton, the Victorian hair and dress may appear quaint and Powers had been at peace for two decades, trade between eugenicist. Among the activities so formal to modern eyes, but this was no nations was prospering and in the fi eld of public and interna- bacteriologists. comprehensively reported by the more than Victorian fashion required. tional health there were pressing issues to address at the annu- medical weeklies (Fig. 1) were those During their careers these men spread al Congresses of Hygiene and Demography. There were new of the Bacteriological section. A section microbiological knowledge throughout health regulations to debate and the recurrent disagreements species on semi-solid media, Pasteur had grudgingly to photograph shows that the Congress the world. They set up academic depart- over what the British Medical Journal (BMJ) referred to as the concede its value. acted as a magnet to the leading medical ments; they wrote the fi rst textbooks; ‘absurdities’ of quarantine to resolve. Fortunately, scientifi c scientists of the day (Fig. 2). Some must they taught our teachers’ teachers. progress was providing more rational bases for action, for The 1891 Congress have been attracted by the novelty example in intervening against the epidemic cholera that had In 1891 London again hosted the Congress. Its scientifi c and potential of the subject and a few, Who’s who several times swept through Europe earlier in the century. proceedings were still almost exclusively men’s business, such as Charles Sherrington, moved See Front row. The seniors are here: There was smallpox and rabies vaccination to discuss, and although the 1890s were to be the decade when women, who on in due course to other disciplines Emile Roux (1853–1933) was a man advances in the treatment of diphtheria and tetanus were on were already discreetly but effectively contributing to work (in his case physiology). Others, like surpassed in importance only by the point of being applied to patients. Ideas about the nature in the laboratory, were at last beginning to be participants Lister, were already among the elder Pasteur in the history of French micro- Fig. 1. A list of the business of the 1891 of humoral and cellular immunity were rapidly evolving. at scientifi c gatherings and not merely accompanying guests. statesmen of scientifi c medicine and biology. He was responsible for deri- Congress of Hygiene and Demography, The presentations and discussions at each Congress were Mostly, though, women had to make do with the extensive brought experience and gravitas to the ving clinical benefi ts from Pasteur’s taken from the Lancet index for that year. lively and often opinionated, and were fully reported in the social programme of receptions, concerts and excursions. proceedings. Pasteur himself might discoveries. John Burdon-Sanderson scientifi c press. An early example had been the exchanges The Lancet and BMJ viedvied withwith eacheach otherother inin describingdescribing thethe have attended if his health and his wife (1828–1905) was a leading British Institute in Paris. Josef Fodor (1843– between Koch and Pasteur at the 1882 International Con- scientifi c proceedings, faithfully reporting their high and had allowed him to do so. Koch also, pathologist, a founder of the short-lived 1901), described in Bulloch’s History gress of Hygiene and Demography in London. The animosity low points. Among the latter were delegates’ complaints (how having just discarded the wife who had Brown Institute and later of the Oxford of Bacteriology as a ‘Hungarian hygienist’, engendered by the Franco-Prussian War had not yet died familiar to organizers of meetings down the years!) that the aided him in his early researches in School of Pathology. Next to him sat reported to the Congress an 1890 down and Koch was the brash young representative of grow- cloakrooms were inadequate, the keynote events unpunctual favour of a young Berlin actress, was Lister who needs no description here. outbreak of 1,000 cases of typhoid ing German imperial power. Pasteur, by contrast, was an and the translation facilities lamentable. In its editorial about detained elsewhere. Another reason Saturnin Arloing (1846–1911) was a due to a hospital’s water closets leaking experienced scientist and a French patriot. Nevertheless, the 1891 Congress the BMJ wrote:wrote: ‘we are loath to dim so bright for Koch’s failure to attend might have comparative pathologist whose school directly into a town water supply, a when Koch demonstrated his technique for isolating bacterial a picture by referring to the innumerable shortcomings, the want been the widespread disenchantment at Lyon rivalled the work of the Pasteur nosocomial infection in reverse. 54 microbiology today may 06 microbiology today may 06 55 from 1887, Director of the Veterinary School at Alfort where did, North American participation. In 1891, the Johns Pasteur and Roux did many of their experiments. Nocard Hopkins School of Public Health in Baltimore had only just was an outstanding researcher. His obituary refers to the been founded, but within a decade it had become one of extraordinary range of his work, and ends with this tribute: the world’s leading hygienic institutes, and was sending ‘at international congresses, which he frequently attended, his out many graduates. George Steinberg, the US Surgeon ready wit and charm of exposition impressed his hearers. What General, was closely associated with the school and wrote he said was always listened to with attention for he never spoke the outstanding contemporary textbook of microbiology in unless he had light to throw upon the subject, the light of a fi nely English. The academic centre of gravity had begun its now critical mind replete with knowledge’. seemingly irreversible shift from Europe to the USA. Watson Cheyne was Lister’s most distinguished pupil. By WWI, the Congresses of Hygiene and Demography had He quickly saw the importance of bacteriology to surgery petered out. The study (or more precisely the use) of the and studied the new science in Berlin and Paris in the early term ‘hygiene’ became unfashionable, its connotations being 1880s. He was a leading fi gure in the application to surgery, too narrow to embrace the widening scope of microbiology. fi rst of antiseptic and then of aseptic technique. Demography, meanwhile, was establishing itself as a separate, Percy Faraday Frankland (b. 1858) taught successively at essentially statistical, discipline and distancing itself from the Royal School of Mines (i.e. Imperial College, London), the eugenic attitudes of the Victorians. Dundee and Birmingham. He pioneered the application of The decline of ‘hygiene’ was also marked by the renaming bacteriological methods to the provision of safe water sup- of various ‘Institutes of Hygiene’ around Europe, and of the plies and the treatment of sewage – not fashionable work Journal of Hygiene itself. Nevertheless, few of the uses to which perhaps, but arguably bringing more human benefi t than microbiology are put can be as important as the promotion the endeavours of most of the delegates. Frankland was of what participants at the 1891 Congress would have more generous than some of his male contemporaries in understood by hygiene, e.g. potable water, effective drainage acknowledging the contribution of his wife; they co-authored and waste disposal, hand and air cleanliness. Today their a textbook. He is also sartorially outstanding – note the wing relevance has certainly not diminished and it could be high collar, the spotted cravat, and the waxed moustache. time to rehabilitate ‘hygiene’ and its associated international David Douglas Cunningham (1843–1914) was a member congresses. of the Indian Medical Service, a student of tropical disease, and a distinguished naturalist. He had travelled furthest to Philip Mortimer attend the Congress (the Japanese Kitasato had been working Health Protection Agency, 61 Colindale Avenue, in Germany for the previous 6 years; only later in 1891 did he London NW9 5HT, UK (t 02080208 327327 6600;6600; return to Tokyo). Cunningham was the leading protagonist e [email protected]) on the Anglo-Indian side in the protracted debate between Middle row. Karl Lehmann (b. 1858) of an authoritative early bacteriology Fig. 2. The Bacteriology Section of the the ‘locationists’ who argued that cholera emerged from Further reading International Congress of Hygiene and published an early atlas of bacteriology textbook. Metschnikoff andand Kitasato the environment, and those who backed Koch’s discovery Adami, J.G. (1889). Notes on an epizootic of rabies; and on Demography 1891. This image hung which went though seven editions. were both soon to become famous for many years on a wall of the Central (achieved in a fortnight’s visit to Calcutta) of a pathogenic a personal experience of M.
Recommended publications
  • 17110-Disseminated-Nocardiosis-A-Case-Report.Pdf
    Open Access Case Report DOI: 10.7759/cureus.5294 Disseminated Nocardiosis: A Case Report Ines M. Leite 1 , Frederico Trigueiros 1 , André M. Martins 1 , Marina Fonseca 1 , Tiago Marques 2 1. Serviço De Medicina 2, Hospital De Santa Maria, Lisboa, PRT 2. Serviço De Doenças Infecciosas, Hospital De Santa Maria, Lisboa, PRT Corresponding author: Ines M. Leite, [email protected] Abstract Disseminated nocardiosis is a rare infection associated with underlying immunosuppression, and patients usually have some identifiable risk factor affecting cellular immunity. Due to advances in taxonomy and microbiology identification methods, infections by Nocardia species are more frequent, making the discussion of its approach and choice of antibiotherapy increasingly relevant. A 77-year-old man presented to the emergency department with marked pain on the right lower limb, weakness, and upper leg edema. He had been diagnosed with organized cryptogenic pneumonia one year before and was chronically immunosuppressed with methylprednisolone 32 mg/day. Blood cultures isolated Nocardia cyriacigeorgica. Computed tomography revealed a gas collection in the region of the right iliacus muscle with involvement of the gluteal and obturator muscles upwardly and on the supragenicular plane inferiorly. Triple therapy with imipenem, amikacin, and cotrimoxazole was started, and the patient was submitted for emergent surgical decompression, fasciotomy, and drainage due to acute compartment syndrome. The patient had a good outcome and was discharged from the hospital after 30 days of intravenous therapy. This case illustrates the severity of Nocardia infection and highlights the need for a meticulous approach in the diagnosis and treatment of these patients. Categories: Internal Medicine, Infectious Disease Keywords: nocardia, nocardia infection, immunosuppression Introduction In the suborder of Corynebacterineae, three genera have strains that may be pathological to humans, with some characteristics similar to Fungi: Mycobacterium, Corynebacterium, and Nocardia.
    [Show full text]
  • The Designing of Anti-Diphtheria Serotherapy at the Institut Pasteur (1888-1900): the Role of a Supranational Network of Microbiologists
    The designing of anti-diphtheria serotherapy at the Institut Pasteur (1888-1900): the role of a supranational network of microbiologists Gabriel Gachelin Rehseis, UMR 7596 CNRS-Université Paris VII. Paris. [email protected] Dynamis Fecha de recepción: 28 de julio de 2006 [0211-9536] 2007; 27: 45-62 Fecha de aceptación: 22 de enero de 2007 SUMMARY: 1.—Introduction. 2.—Shuttling of research on diphtheria between France and Germany. 3.—The designing of French standards and norms in accordance with German ones. 4.—The rapid decline of strong anti-German feelings at the Institut Pasteur. ABSTRACT: The development of anti-diphtheria serotherapy at the Institut Pasteur immedia- tely follows the crisis known as the Pasteur-Koch debate. Research on diphtheria in Paris is indicative of the importance granted by Pasteurian scientists to Koch’s school criticisms. After 1887, relations between French and German bacteriologists become more relaxed. A scientific and social network develops between them. It later extends to other fields of research at the Institut Pasteur, particularly therapeutic chemistry. The evolution of Franco-German relations at the Institut Pasteur is placed in the general framework of the way French universities con- sidered German science. PALABRAS CLAVE: Difteria, seroterapia, relaciones franco-alemanas, red científica, Roux, von Behring. KEYWORDS: diphtheria, serotherapy, Franco-German relations, scientific network, Roux, von Behring. 1. Introduction A violent debate between Louis Pasteur (1822-1895) and Robert Koch (1843- 1910) broke out in 1881 on the issue of the vaccination against anthrax soon after the International Congress of Medicine in London held in August of that year.
    [Show full text]
  • The Greatest Steps Towards the Discovery of Vibrio Cholerae
    REVIEW 10.1111/1469-0691.12390 The greatest steps towards the discovery of Vibrio cholerae D. Lippi1 and E. Gotuzzo2 1) Experimental and Clinical Medicine, University of Florence, Florence, Italy and 2) Institute of Tropical Medicine, Peruvian University, C. Heredia, Lima, Peru Abstract In the 19th century, there was extensive research on cholera: the disease was generally attributed to miasmatic causes, but this concept was replaced, between about 1850 and 1910, by the scientifically founded germ theory of disease. In 1883, Robert Koch identified the vibrion for the second time, after Filippo Pacini’s discovery in 1854: Koch isolated the comma bacillus in pure culture and explained its mode of transmission, solving an enigma that had lasted for centuries. The aim of this article is to reconstruct the different steps towards the explanation of cholera, paying particular attention to the events occurring in the pivotal year 1854. Keywords: Filippo Pacini, history of cholera, John Snow, Robert Koch, vibrion Article published online: 12 September 2013 Clin Microbiol Infect 2014; 20: 191–195 Corresponding author: D. Lippi, Experimental and Clinical Medicine, University of Florence, Florence, Italy E-mail: donatella.lippi@unifi.it seriously affected almost the whole world during many severe Introduction outbreaks in the course of the 19th century [2]. This diarrhoeal disease can lead to death by dehydration of an untreated In the 19th century, there was extensive research on cholera: patient within a few hours, and is extremely contagious in among the topics discussed were microbial vs. miasmatic causes communities without adequate sanitation. Even though it was and the relative merits of hygiene, sanitation and quarantine in hard to discriminate cholera from many other diseases controlling or preventing cholera’s spread, especially among associated with diarrhoea and vomiting, the first pandemic of European nations.
    [Show full text]
  • The Emergence of French Medical Entomology: the Influence of Universities, the Institut Pasteur and Military Physicians (1890–C.1938)
    Medical History, 2008, 52: 387–405 The Emergence of French Medical Entomology: The Influence of Universities, the Institut Pasteur and Military Physicians (1890–c.1938) ANNICK OPINEL* The term medical entomology (entomologie me´dicale) was used for the first time in France around 1910. As far as France is concerned,1 the study of arthropods as critical components in the propagation of severe diseases such as yellow fever, trypanosomiasis, and malaria gradually emerged after 1890 in three main types of institution: civilian faculties of medicine, a specialized military medical training centre, and the Institut Pasteur. In each of these settings, medical entomology developed from different ratio- nales and interests, and came to influence different spheres of activity. Although identified very early in France—in the last decade of the nineteenth century—as the necessary associate of parasitology and the study of tropical diseases, it was nearly twenty years before medical entomology became a defined field of knowledge within the wider dis- cipline of entomology. The present article surveys the respective roles of the three teaching and research institutions that played a part in the emergence of medical entomology in France. Not only were these institutions the major actors in the country at the time, but, despite their differences, they were destined in some way closely to collaborate or to create parallel international networks of research and teaching while generating a complex array of subsidiary institutions, nearly all dealing with
    [Show full text]
  • The Origin of the Production of Diphtheria Antitoxin in France, Between Philanthropy and Commerce
    The origin of the production of diphtheria antitoxin in France, between philanthropy and commerce Jonathan Simon LEPS (EA 4148), La Pagode, Université Lyon 1, F-69622 Villeurbanne Cedex, France. [email protected] Dynamis Fecha de recepción: 27 de septiembre de 2006 [0211-9536] 2007; 27: 63-82 Fecha de aceptación: 31 de enero de 2007 SUMMARY: 1.—Introduction. 2.—The origins of the serum. 3.—The production process. 4.—Serum at the Pasteur Institute; the pros and cons of media exposure. 5.—The serum and the finances of the Pasteur Institute. 6.—The serum legislation. 7.—French culture and the serum industry. 8.—Conclusion: serum in European cultures. ABSTRACT: Serotherapy for the treatment of diphtheria represented a major therapeutic in- novation at the end of the nineteenth century. The manner in which large-scale production of this medicament was undertaken and the regulations that governed its production and distribution were important elements of public health policy in France as in other European countries. This paper describes the dominance of the Pasteur Institute in this field and, starting from this observation, explores what this event in the history of medicine can tell us about the governance of public health in fin-de-siècle France. The particular organization of this institute and its monopoly of specialist microbiological knowledge allowed it to raise money for serum production from both private and public sources, walking the line between a com- mercial pharmaceutical venture and a philanthropic enterprise. PALABRAS CLAVE: seroterapia, Instituto Pasteur, Tercera República, cruz, Salud Pública. KEYWORDS: serotherapy, Pasteur Institute, Third Republic, Croup, Public Health.
    [Show full text]
  • Monsieur Roux, Un Bienfaiteur De L'humanité
    FBIO 345 INT.qxp 17/10/2018 16:14 Page51 BIOLOGIE ET HISTOIRE Émile Roux Monsieur Roux, un bienfaiteur de l’humanité M. SIMONET1 résumé Fils spirituel d’Émile Duclaux, assistant de Louis Pasteur, Émile Roux a été l’un des fondateurs de la micro- biologie et parmi les pionniers en pathologie infectieuse. Ses expérimentations animales sur la rage ont contri- bué à la mise au point du vaccin antirabique, mais son œuvre scientifique maîtresse reste l’étude de la diph- térie et ses recherches dans cette maladie ainsi que celles concernant le tétanos, une autre toxi-infection, qui ont fait de lui un bienfaiteur de l’humanité. Maître d’œuvre de l’Institut Pasteur, puis de l’hôpital pavillonnaire attenant destiné aux maladies contagieuses, Émile Roux dirigera l’institution à partir de 1904 et pendant près de 30 ans, assurant son développement et son expansion à travers le monde. Il a créé le premier cours de microbiologie au monde, de renommée internationale, qui formera au fil des ans de très nombreux élèves de diverses nationalités. mots-clés : toxine diphtérique, toxi-infection, sérothérapie, rage, Louis Pasteur, Émile Duclaux, Institut Pas- teur, cours de microbie technique. I. - INTRODUCTION II. - LA JEUNESSE, DE CONFOLENS AU PUY Les recherches de Louis Pasteur entreprises au Pierre Paul Émile Roux naît le 17 décembre 1853 tout début de la seconde moitié du XIXe siècle, au collège de Confolens (Charente). Ses parents sont concernant les fermentations et la putréfaction puis d’origine charentaise. Jean, son père, licencié ès-let- deux maladies des vers à soie (la pébrine et la flache- tres, est le Principal du collège ; Marthe-Pauline (née rie) dévastant les magnaneries des Cévennes, le Pintaud), sa mère, est la directrice de l’internat.
    [Show full text]
  • Historical Review of BCG Vaccine in Japan
    Jpn. J. Infect. Dis., 60, 331-336, 2007 Invited Review Historical Review of BCG Vaccine in Japan Saburo Yamamoto1,2* and Toshiko Yamamoto1 1Department of Microbial and Molecular Pathogenesis, Texas A & M University Health Science Center, College of Medicine, Texas, USA, and 2Ex Laboratory of Tuberculosis Control, Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Tokyo 208-0011, Japan (Received June 29, 2007) CONTENTS: 1. Introduction 4. Quality control 2. BCG vaccine in Japan 5. Vaccine efficacy 2-1. Freeze-dried vaccine 6. Adverse reactions 2-2. Percutaneous administration 7. Genetic characterization of BCG strains 3. Vaccine production 8. Aspects of BCG vaccines SUMMARY: Bacillus Calmette and Guérin (BCG) was introduced to Japan in 1924 by Kiyoshi Shiga and has been propagated for research purposes ever since propagation is accomplished using a glycerin-bile-potato mixture in the same manner used by Calmette and Guérin. To prepare a stable and safe freeze-dried BCG vaccine, several joint research projects were organized in 1949. At the National Institute of Infectious Diseases (formerly the National Institute of Health), the 172nd passage of BCG from the first culture was freeze-dried in 1961 and was used as the origin of the Japanese BCG strain, Tokyo-172. The Tokyo-172 was registered as an International Reference Strain in 1965 by the World Health Organization. In 1967, a multiple puncture method for BCG vaccination using a plastic cylinder implanted with nine fine needles at one end was introduced to Japan; there- after, percutaneous administration replaced intradermal injection. The efficacy and adverse reactions of BCG vaccines as well as recent knowledge on the genetic characterization of BCG is also discussed.
    [Show full text]
  • Ravenel, Mazÿck Porcher (1861-1946), Papers, 1884-1958, (C0578)
    C Ravenel, Mazÿck Porcher (1861-1946), Papers, 1884-1958 578 1.7 linear feet, 1 card file INTRODUCTION Papers of a bacteriologist and teacher, including correspondence, notes, and other material. Information on disease research, health organizations, other scientists, World War I army life, the University of Wisconsin in 1914, and effects of World War II on Columbia, Missouri. DONOR INFORMATION The papers were donated to the University of Missouri by the Medical Library on 30 October 1968 (Accession No. 3783). BIOGRAPHICAL SKETCH Mazÿck Porcher Ravenel was born in Pendleton, South Carolina, in 1861, the son of Henry Edmund and Selma E. Ravenel. He graduated from the University of the South in 1881, and received the M.D. at the Medical College of the State of South Carolina in 1884. He married Jennie Carlile Boyd in 1898, and in 1910, Adele Pettigru Vander Horst. A cofounder of the Charleston Medical School, he practiced medicine in Charleston for six years before leaving in 1894 to attend the Pasteur Institute in Paris, France, and work with Carl Fraenkel at the Hygienic Institute, University of Halle, Germany, 1895. Ravenel served as first director of the Hygienic Laboratory of the New Jersey State Board of Health, 1895; bacteriologist for the Pennsylvania State Live Stock Sanitary Board, 1896-1904; and instructor of bacteriology, Medical and Veterinary Schools, University of Pennsylvania, 1896. He challenged the bovine tuberculosis theory of Robert Koch at the Third International Tuberculosis Congress, London, England, 1901, and isolated a bovine tubercle bacilli from tuberculous children, 1902. He acted as assistant medical director and chief of the laboratory, Phipps Institute for the Study, Treatment and Prevention of Tuberculosis, 1904-1907; professor of bacteriology, University of Wisconsin, 1907-1914; director of the State Hygienic Laboratory of Wisconsin, 1908-1914; and president, Wisconsin Antituberculosis Society.
    [Show full text]
  • The Role of the Veterinary Surgeons in Developing Theoretical and Clinical Immunology Rolul Medicilor Veterinari În Dezvoltarea Imunologiei Teoretice Şi Clinice
    50 Rev Rom Med Vet (2017) 27 | 1: 50-60 THE ROLE OF THE VETERINARY SURGEONS IN DEVELOPING THEORETICAL AND CLINICAL IMMUNOLOGY ROLUL MEDICILOR VETERINARI ÎN DEZVOLTAREA IMUNOLOGIEI TEORETICE ŞI CLINICE R. IFTIMOVICI1) For more than 150 years (1850-2010) veterinary De mai bine de 150 de ani (1850-2010), medicii surgeons made a crucial contribution to laying the veterinari au avut o contribuție esențială în punerea basis of and developing immunology. Starting with bazelor şi dezvoltării imunologiei. Pornind de la pri- the first attempts at immunizing bovine pleuropneu- mele încercări de imunizare a pleuropneumoniei bovi- monia (Louis Willems; 1852-1880), and continuing ne (Louis Willems, 1852-1880) și continuând cu apa- with the advent of the germ theory of infectious and riția teoriei germenelui bolilor infecțioase și contagi- contagious diseases of Louis Pasteur and Robert oase ale lui Louis Pasteur şi Robert Koch, medicii vete- Koch, veterinary surgeons like Henri Bouley, Henri rinari precum Henri Bouley, Henri Toussaint, Pierre- Toussaint, Pierre-Victor Galtier and William Schutz Victor Galtier și William Schutz au colaborat îndea- worked closer with doctors and biochemists in giving proape cu medici şi biochimişti pentru conturarea shape to contemporary immunology. imunologiei contemporane. The article also deals with the second generation Articolul de faţă se ocupă de asemenea, cu a doua of veterinary immunologists such as Edmond Nocard generație de imunologi veterinari, cum ar fi Edmond with his research on human and animal tuberculosis,
    [Show full text]
  • The Greatest Steps Towards the Discovery of Vibrio Cholerae
    REVIEW 10.1111/1469-0691.12390 The greatest steps towards the discovery of Vibrio cholerae D. Lippi1 and E. Gotuzzo2 1) Experimental and Clinical Medicine, University of Florence, Florence, Italy and 2) Institute of Tropical Medicine, Peruvian University, C. Heredia, Lima, Peru Abstract In the 19th century, there was extensive research on cholera: the disease was generally attributed to miasmatic causes, but this concept was replaced, between about 1850 and 1910, by the scientifically founded germ theory of disease. In 1883, Robert Koch identified the vibrion for the second time, after Filippo Pacini’s discovery in 1854: Koch isolated the comma bacillus in pure culture and explained its mode of transmission, solving an enigma that had lasted for centuries. The aim of this article is to reconstruct the different steps towards the explanation of cholera, paying particular attention to the events occurring in the pivotal year 1854. Keywords: Filippo Pacini, history of cholera, John Snow, Robert Koch, vibrion Clin Microbiol Infect Corresponding author: D. Lippi, Experimental and Clinical Medicine, University of Florence, Florence, Italy E-mail: donatella.lippi@unifi.it seriously affected almost the whole world during many severe Introduction outbreaks in the course of the 19th century [2]. This diarrhoeal disease can lead to death by dehydration of an untreated In the 19th century, there was extensive research on cholera: patient within a few hours, and is extremely contagious in among the topics discussed were microbial vs. miasmatic causes communities without adequate sanitation. Even though it was and the relative merits of hygiene, sanitation and quarantine in hard to discriminate cholera from many other diseases controlling or preventing cholera’s spread, especially among associated with diarrhoea and vomiting, the first pandemic of European nations.
    [Show full text]
  • Relevance of Bovine Tuberculosis Research to the Understanding of Human Disease
    Veterinary Immunology and Immunopathology 159 (2014) 113–132 Contents lists available at ScienceDirect Veterinary Immunology and Immunopathology j ournal homepage: www.elsevier.com/locate/vetimm Relevance of bovine tuberculosis research to the understanding of human disease: Historical perspectives, approaches, and immunologic mechanisms a,∗,1 a b W. Ray Waters , Mayara F. Maggioli , Jodi L. McGill , c a Konstantin P. Lyashchenko , Mitchell V. Palmer a Infectious Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Ames, IA, United States b Ruminant Diseases and Immunology Research Unit, National Animal Disease Center, Ames, IA, United States c Chembio Diagnostic Systems Inc., Medford, NY, United States a r t i c l e i n f o a b s t r a c t Pioneer studies on infectious disease and immunology by Jenner, Pasteur, Koch, Von Keywords: Behring, Nocard, Roux, and Ehrlich forged a path for the dual-purpose with dual ben- Bovine tuberculosis efit approach, demonstrating a profound relevance of veterinary studies for biomedical Central memory T cells applications. Tuberculosis (TB), primarily due to Mycobacterium tuberculosis in humans and Multi-functional T cells ␥␦ T cells Mycobacterium bovis in cattle, is an exemplary model for the demonstration of this concept. IL-17 Early studies with cattle were instrumental in the development of the use of Koch’s tuber- IP-10 culin as an in vivo measure of cell-mediated immunity for diagnostic purposes. Calmette M. bovis specific antibody and Guerin demonstrated the efficacy of an attenuated M. bovis strain (BCG) in cattle prior to use of this vaccine in humans. The interferon-␥ release assay, now widely used for TB diagnosis in humans, was developed circa 1990 for use in the Australian bovine TB erad- ication program.
    [Show full text]
  • Edmond Nocard (1850-1903) Et Le Centenaire De La Découverte Du Premier Mycoplasme (1898) *
    Edmond Nocard (1850-1903) et le centenaire de la découverte du premier mycoplasme (1898) * par Claude CHASTEL ** 1898 fut une année particulièrement riche en découvertes microbiologiques de premier plan : la mise en évidence expéri­ mentale, par P.L. Simond, du rôle de la puce du rat dans la transmission de la peste (1), la confirmation par M. Beijerinck (2) du caractère filtrant du virus de la mosaïque du tabac et l'énoncé, par le même auteur, du concept de Contagium vivum fluidum, d'ailleurs très mal accepté par les autres bactériologistes, enfin, la découverte du virus de la myxomatose du lapin par G. Sanarelli (3). Mais, surtout, c'est l'isolement du "virus" de la péripneumonie des bovidés (PPB), par E. Nocard, E. Roux, A. Borrel, A.T. Salimbeni et L. Dujardin-Baumetz, à Paris (4), qui retiendra notre attention, car cet événement eut un très large retentisse­ ment immédiat et des conséquences Edmond Nocard (1850-1903) durables pour la Microbiologie Générale et (Archives départementales - Val de Marne) la Virologie. Ce fut en effet le premier mycoplasme à être isolé, mais on était encore loin de le savoir. Ses découvreurs pensèrent qu'il s'agissait d'un autre virus fil­ trant (5). Ce travail fut publié dans les toutes nouvelles Annales de l'Institut Pasteur fondées par Emile Duclaux (1886). * Comité de lecture du 19 décembre 1998 de la Société française d'Histoire de la Médecine. ** Laboratoire de Virologie, Faculté de Médecine, 29285 Brest cedex. HISTOIRE DES SCIENCES MÉDICALES - TOME XXXIII - №4 - 1999 311 La découverte de l'agent de la péripneumonie des bovidés Au début de leur article, E.
    [Show full text]