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European Patent Office of Opposition to That Patent, in Accordance with the Implementing Regulations (19) *EP003442493B1* (11) EP 3 442 493 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: A61K 8/34 (2006.01) A61K 8/55 (2006.01) (2006.01) (2006.01) 18.12.2019 Bulletin 2019/51 A61Q 17/00 A61Q 19/10 A61K 31/045 (2006.01) A61K 31/05 (2006.01) (2006.01) (2006.01) (21) Application number: 17714740.2 A61K 31/685 A61P 31/02 C11D 3/48 (2006.01) A01N 31/04 (2006.01) A01N 31/08 (2006.01) A01N 33/12 (2006.01) (22) Date of filing: 30.03.2017 A01N 57/12 (2006.01) C11D 1/62 (2006.01) C11D 3/20 (2006.01) (86) International application number: PCT/EP2017/057610 (87) International publication number: WO 2017/178240 (19.10.2017 Gazette 2017/42) (54) AN ANTIMICROBIAL COMPOSITION COMPRISING THYMOL, TERPINEOL AND A CATIONIC PHOSPHOLIPID ANTIMIKROBIELLE ZUSAMMENSETZUNG ENTHALTEND THYMOL, TERPINIEOL UND EIN KATIONISCHES PHOSPHOLIPID COMPOSITION ANTIMICROBIENNE COMPRENANT DU THYMOL, DU TERPINEOL ET UN PHOSPHOLIPIDE CATIONIQUE (84) Designated Contracting States: • GU, Qiong AL AT BE BG CH CY CZ DE DK EE ES FI FR GB Shanghai (CN) GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO • HERMANSON, Kevin, David PL PT RO RS SE SI SK SM TR Trumbull Connecticut 06611 (US) (30) Priority: 14.04.2016 PCT/CN2016/079293 • MOADDEL, Teanoosh 27.06.2016 EP 16176486 Trumbull Connecticut 06611 (US) (43) Date of publication of application: • SALGAONKAR, Neha 20.02.2019 Bulletin 2019/08 Whitefield 560 066 Bangalore Karnataka (IN) (73) Proprietors: • SHEN, Bo • Unilever N.V. Shanghai (CN) 3013 AL Rotterdam (NL) •QIU, Qiang Designated Contracting States: Trumbull AL AT BE BG CH CZ DE DK EE ES FI FR GR HR Connecticut 06611 (US) HU IS IT LI LT LU LV MC MK NL NO PL PT RO RS SE SI SK SM TR (74) Representative: van den Brom, Coenraad Richard • Unilever PLC Unilever Patent Group London, Greater London EC4Y 0DY (GB) Bronland 14 Designated Contracting States: 6708 WH Wageningen (NL) CY GB IE MT (56) References cited: (72) Inventors: EP-A1- 2 348 838 US-A1- 2005 101 515 • DASGUPTA, Anindya US-A1- 2014 045 692 US-A1- 2015 306 007 Whitefield 560 066 Bangalore (IN) Note: Within nine months of the publication of the mention of the grant of the European patent in the European Patent Bulletin, any person may give notice to the European Patent Office of opposition to that patent, in accordance with the Implementing Regulations. Notice of opposition shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention). EP 3 442 493 B1 Printed by Jouve, 75001 PARIS (FR) (Cont. next page) EP 3 442 493 B1 • DATABASE GNPD [Online] MINTEL; 4 June 2016 (2016-06-04), ANONYMOUS: "Anti acne leave-on expert clearing gel", XP002761835, retrieved from www.gnpd.com Database accession no. 4091587 • Manuel. Viuda-Martos ET AL: "Chemical composition of the essential oils obtained from some spices widely used in mediterranean region", Acta Chim. Slov., vol. 54 1 January 2007 (2007-01-01), pages 921-926, XP055302524, Retrieved from the Internet: URL:http://acta-arhiv.chem-soc.si/54/54-4- 921.pdf [retrieved on 2016-09-14] 2 EP 3 442 493 B1 Description Technical Field 5 [0001] The present invention relates to an antimicrobial composition and more particularly an antimicrobial composition for leave-on applications. Background of the invention 10 [0002] People try to take good care of the external surface of their bodies. Specific skin related issues that people care about include good skin health free of infections, good skin tone and skin hygiene. Skin hygiene is generally achieved by keeping them free of infections. One way to tackle infections is to treat them with antimicrobials after the infection has set in. Another approach is to leave a minimal amount of antimicrobial active on the surface so that any invading microorganism is killed or inactivated to minimize spread of diseases. Yet another approach is improving the innate 15 immunity of the desired surface. [0003] The greatness of leave-on formulation is that it remains on the skin after the application. Therefore, one can deliver enhanced antimicrobial activity through leave-on formulations. [0004] There are different antimicrobial compositions known in the art: WO 2010/046238 (Unilever) discloses an antimicrobial composition for cleansing or personal care. It is an object of the 20 present invention to provide antimicrobial compositions that have relatively fast antimicrobial action. Present inventors have surprisingly found that compositions comprising selected ingredients, namely thymol and terpineol, in selective propositions provide relatively quick antimicrobial action. [0005] US 2004/0014818 (Boeck) discloses a bactericidal preparation in the form of a solution, cream or ointment compounded from photosynthesized hydrocarbons, isolates from hydrocarbons, 2-hydroxy-1-isopropyl-4-methyl ben- 25 zene (thymol) and butylated hydroxytoluene and exemplifies many compositions, each having from 10 to 20 compounds having anti-bacterial efficacy. [0006] GB508407 (Shepherd, 1938) describes an antiseptic product and method of preparation thereof comprising the steps of mixing salol and thymol in weight ratio of 1:3, melting the mixture and cooling to form crystals. An example of composition comprising 59 parts of the crystals, 41 parts of terpineol, 200 parts of red turkey oil and 200 parts of water 30 is described. The composition described in this document comprises about 8% by weight thymol and about 8% by weight terpineol and is said to be particularly useful for disinfection of air. [0007] Though the prior art discloses compositions for antimicrobial benefits, still there is a need to provide an anti- microbial leave-on composition which can have antimicrobial efficacy for long time with minimal amount of known anti- microbial ingredients. 35 [0008] It is therefore an object of the present invention to provide an antimicrobial composition. [0009] It is another object of the present invention to provide an antimicrobial composition for leave-on application. [0010] It is yet another object of the present invention to provide an antimicrobial composition for leave-on application, which has prolonged antimicrobial activity. [0011] It is yet a further object of the present invention to provide an antimicrobial composition for leave-on application 40 that employs minimal amount of known antimicrobial compounds. [0012] The present inventors while working extensively on this have surprisingly found that a composition with a little amount of thymol, terpineol and a cationic phospholipid complex provides an antimicrobial composition with good and prolonged antimicrobial activity which cannot be achieved by using little amount of only thymol and terpineol thereby satisfying one or more of the above mentioned objects. 45 Summary of the invention [0013] In a first aspect, the present invention provides an antimicrobial composition comprising; 50 a) 0.01 to 2% by weight of thymol; b) 0.01 to 2% by weight of terpineol; and c) 0.1 to 2% by weight of a cationic phospholipid complex, wherein the cationic phospholipid complex is Linoleam- idopropyl PG-Dimonium Chloride Phosphate. 55 [0014] In a second aspect, the present invention provides a non-therapeutic method of disinfecting a surface comprising the steps of applying a composition of the first aspect on to said surface. [0015] In a third aspect, the present invention provides a non-therapeutic use of a cationic phospholipid complex in an antimicrobial composition comprising thymol and terpineol to increase the antimicrobial activity. 3 EP 3 442 493 B1 [0016] The word "comprising" is intended to mean "including" but not necessarily "consisting of" or "composed of." In other words, the listed steps or options need not be exhaustive. Except in the operating and comparative examples, or where otherwise explicitly indicated, all numbers in this description indicating amounts of material or conditions of reaction, physical properties of materials and/or use are to be understood as modified by the word "about". Numerical ranges 5 expressed in the format "from x to y" are understood to include x and y. When for a specific feature multiple preferred ranges are described in the format "from x to y", it is understood that all ranges combining the different endpoints are also contemplated. Detailed description of the invention 10 [0017] The present invention provides an antimicrobial composition comprising; a) 0.01 to 2% by weight of thymol; b) 0.01 to 2% by weight of terpineol; and 15 c) 0.1 to 2% by weight of a cationic phospholipid complex, wherein the cationic phospholipid complex is Linoleam- idopropyl PG-Dimonium Chloride Phosphate. [0018] Antimicrobial composition as mentioned herein above preferably means any composition which is capable of killing or at least cause substantial reduction of the common disease causing microbes. The common disease causing 20 gram-positive organisms includes Staphylococcus, Streptococcus and Enterococcus spp. Some of common disease causing gram-negative organisms includes Escherichia coli, Salmonella, Klebsiella and Shigella. Escherichia coli and Salmonella can cause severe gastrointestinal illnesses. [0019] The composition of the present invention is preferably in the form of a leave-on composition. Leave-on com- position preferably means compositions that are applied on a surface (e.g. skin) without a subsequent step of washing 25 the surface to effect the removal of the composition after the application. This preferably means the compositions stays on the surface after the application. Thymol: 30 [0020] The antimicrobial composition of the present invention comprises thymol. The amount of thymol preferably is in the range of 0.01 to 2%, more preferably 0.01 to 1% and further more preferably 0.01 to 0.5%, most preferably 0.01 to 0.1 % and further most preferably 0.01 to 0.05%.
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