RPPR Page 23 RPPR FINAL C. OVERALL PRODUCTS C.1

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C. OVERALL PRODUCTS

C.1 PUBLICATIONS

Are there publications or manuscripts accepted for publication in a journal or other publication (e.g., book, one-time publication, monograph) during the reporting period resulting directly from this award?

Yes

Publications Reported for this Reporting Period

Public Access Compliance Citation

Complete Harmon AC, Ibrahim T, Cornelius DC, Amaral LM, Cunningham MW Jr, Wallace K, LaMarca B. Placental CD4⁺ T cells isolated from preeclamptic women cause preeclampsia-like symptoms in pregnant nude-athymic rats. Pregnancy hypertension. 2019 January;15:7-11. PubMed PMID: 30825930; PubMed Central PMCID: PMC6613642; DOI: 10.1016/j.preghy.2018.10.007.

Complete Lohmeier TE, Hall JE. Device-Based Neuromodulation for Resistant Hypertension Therapy. Circulation research. 2019 March 29;124(7):1071-1093. PubMed PMID: 30920919; PubMed Central PMCID: PMC6442942; DOI: 10.1161/CIRCRESAHA.118.313221.

Complete Adeosun SO, Hou X, Shi L, Stockmeier CA, Zheng B, Raffai RL, Weisgraber KH, Mosley TH, Wang JM. Female mice with apolipoprotein E4 domain interaction demonstrated impairments in spatial learning and memory performance and disruption of hippocampal cyto-architecture. Neurobiology of learning and memory. 2019 May;161:106-114. PubMed PMID: 30954674; PubMed Central PMCID: PMC6628694; DOI: 10.1016/j.nlm.2019.03.012.

Complete Kishore S, Jatwani S, Malhotra B, Lirette ST, Mittal V, Majithia V. Systemic Lupus Erythematosus Is Associated With a High Risk of Venous Thromboembolism in Hospitalized Patients Leading to Poor Outcomes and a Higher Cost: Results From Nationwide Inpatient Sample Database 2003-2011. ACR open rheumatology. 2019 May;1(3):194-200. PubMed PMID: 31777795; PubMed Central PMCID: PMC6858019; DOI: 10.1002/acr2.1030.

Complete Reckelhoff JF, Romero DG, Yanes Cardozo LL. Sex, Oxidative Stress, and Hypertension: Insights From Animal Models. Physiology (Bethesda, Md.). 2019 May 1;34(3):178-188. PubMed PMID: 30968750; PubMed Central PMCID: PMC6734067; DOI: 10.1152/physiol.00035.2018.

Complete Terstappen F, Spradley FT, Bakrania BA, Clarke SM, Joles JA, Paauw ND, Garrett MR, Lely AT, Sasser JM. Prenatal Sildenafil Therapy Improves Cardiovascular Function in Fetal Growth Restricted Offspring of Dahl Salt-Sensitive Rats. Hypertension (Dallas, Tex. : 1979). 2019 May;73(5):1120-1127. PubMed PMID: 30827146; PubMed Central PMCID: PMC6458081; DOI: 10.1161/HYPERTENSIONAHA.118.12454.

Complete Zhang X, Yasuda K, Gilmore RA, Westmoreland SV, Platt DM, Miller GM, Vallender EJ. Alcohol-induced changes in the gut microbiome and metabolome of rhesus macaques. Psychopharmacology. 2019 May;236(5):1531-1544. PubMed PMID: 30903211; PubMed Central PMCID: PMC6613802; DOI: 10.1007/s00213-019-05217-z.

Complete Gordon DM, Blomquist TM, Miruzzi SA, McCullumsmith R, Stec DE, Hinds TD Jr. RNA sequencing in human HepG2 hepatocytes reveals PPAR-α mediates transcriptome responsiveness of bilirubin. Physiological genomics. 2019 June 1;51(6):234-240. PubMed PMID: 31074682; PubMed Central PMCID: PMC6620644; DOI: 10.1152/physiolgenomics.00028.2019.

Complete Taylor EB, Wolf VL, Dent E, Ryan MJ. Mechanisms of hypertension in autoimmune rheumatic diseases. British journal of pharmacology. 2019 June;176(12):1897-1913. PubMed PMID: 30714094; PubMed Central PMCID: PMC6534791; DOI: 10.1111/bph.14604.

Complete Taylor EB, Ryan MJ. Freedom isn't always free: immunoglobulin free light chains promote renal fibrosis. The Journal of clinical investigation. 2019 June 17;129(7):2660- 2662. PubMed PMID: 31205026; PubMed Central PMCID: PMC6597214; DOI: 10.1172/JCI129704.

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Complete Drummond HA, Mitchell ZL, Abraham NG, Stec DE. Targeting Heme Oxygenase-1 in Cardiovascular and Kidney Disease. Antioxidants (Basel, Switzerland). 2019 June 18;8(6). PubMed PMID: 31216709; PubMed Central PMCID: PMC6617021; DOI: 10.3390/antiox8060181.

Complete Parajuli P, Singh P, Wang Z, Li L, Eragamreddi S, Ozkan S, Ferrigno O, Prunier C, Razzaque MS, Xu K, Atfi A. TGIF1 functions as a tumor suppressor in pancreatic ductal adenocarcinoma. The EMBO journal. 2019 July 1;38(13):e101067. PubMed PMID: 31268604; PubMed Central PMCID: PMC6601038; DOI: 10.15252/embj.2018101067.

Complete Reckelhoff JF, LaMarca B, Garovic VD, Alexander BT. Human Umbilical Venous Endothelial Cells: Early Predictors of Cardiovascular Risk in Offspring?. Hypertension (Dallas, Tex. : 1979). 2019 July;74(1):32-34. PubMed PMID: 31154902; PubMed Central PMCID: PMC6782069; DOI: 10.1161/HYPERTENSIONAHA.119.12652.

Complete Chung WC, Zhou Y, Atfi A, Xu K. Downregulation of Notch Signaling in Kras-Induced Gastric Metaplasia. Neoplasia (New York, N.Y.). 2019 August;21(8):810-821. PubMed PMID: 31276933; PubMed Central PMCID: PMC6611983; DOI: 10.1016/j.neo.2019.06.003.

Complete Maeda KJ, Showmaker KC, Johnson AC, Garrett MR, Sasser JM. Spontaneous superimposed preeclampsia: chronology and expression unveiled by temporal transcriptomic analysis. Physiological genomics. 2019 August 1;51(8):342-355. PubMed PMID: 31125289; PubMed Central PMCID: PMC6732412; DOI: 10.1152/physiolgenomics.00020.2019.

Complete Giambrone AB, Logue OC, Shao Q, Bidwell GL 3rd, Warrington JP. Perinatal Micro- Bleeds and Neuroinflammation in E19 Rat Fetuses Exposed to Utero-Placental Ischemia. International journal of molecular sciences. 2019 August 20;20(16). PubMed PMID: 31434191; PubMed Central PMCID: PMC6720786; DOI: 10.3390/ijms20164051.

Complete Ashraf S, Hegazy YK, Harmancey R. Nuclear receptor subfamily 4 group A member 2 inhibits activation of ERK signaling and cell growth in response to β-adrenergic stimulation in adult rat cardiomyocytes. American journal of physiology. Cell physiology. 2019 September 1;317(3):C513-C524. PubMed PMID: 31188636; PubMed Central PMCID: PMC6766613; DOI: 10.1152/ajpcell.00526.2018.

Complete Dragojevic S, Mackey R, Raucher D. Evaluation of Elastin-Like Polypeptides for Tumor Targeted Delivery of Doxorubicin to Glioblastoma. Molecules (Basel, Switzerland). 2019 September 6;24(18). PubMed PMID: 31489879; PubMed Central PMCID: PMC6767252; DOI: 10.3390/molecules24183242.

Complete Gordon DM, Adeosun SO, Ngwudike SI, Anderson CD, Hall JE, Hinds TD Jr, Stec DE. CRISPR Cas9-mediated deletion of biliverdin reductase A (BVRA) in mouse liver cells induces oxidative stress and lipid accumulation. Archives of biochemistry and biophysics. 2019 September 15;672:108072. PubMed PMID: 31422074; PubMed Central PMCID: PMC6718297; DOI: 10.1016/j.abb.2019.108072.

Complete Davis GK, Intapad S, Newsome AD, Coats LE, Bamrick DR, Ojeda NB, Alexander BT. Androgen Receptor Blockade Differentially Regulates Blood Pressure in Growth- Restricted Versus Ovarian Deficient Rats. Hypertension (Dallas, Tex. : 1979). 2019 October;74(4):975-982. PubMed PMID: 31378101; PubMed Central PMCID: PMC6739128; DOI: 10.1161/HYPERTENSIONAHA.119.13257.

Complete Yang Y, Gomez-Sanchez CE, Jaquin D, Aristizabal Prada ET, Meyer LS, Knösel T, Schneider H, Beuschlein F, Reincke M, Williams TA. Primary Aldosteronism: KCNJ5 Mutations and Adrenocortical Cell Growth. Hypertension (Dallas, Tex. : 1979). 2019 October;74(4):809-816. PubMed PMID: 31446799; PubMed Central PMCID: PMC6739168; DOI: 10.1161/HYPERTENSIONAHA.119.13476.

Complete Mahdi F, Chade AR, Bidwell GL 3rd. Utilizing a Kidney-Targeting Peptide to Improve Renal Deposition of a Pro-Angiogenic Protein Biopolymer. Pharmaceutics. 2019 October 18;11(10). PubMed PMID: 31635263; PubMed Central PMCID: PMC6835230; DOI: 10.3390/pharmaceutics11100542.

Complete Engel JE, Williams E, Williams ML, Bidwell GL 3rd, Chade AR. Targeted VEGF (Vascular Endothelial Growth Factor) Therapy Induces Long-Term Renal Recovery in Chronic Kidney Disease via Macrophage Polarization. Hypertension (Dallas, Tex. : 1979). 2019 November;74(5):1113-1123. PubMed PMID: 31542966; PubMed Central PMCID: PMC6785403; DOI: 10.1161/HYPERTENSIONAHA.119.13469.

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Complete Patel J, Ramarao S, Desai J, Savich R, Patel A. A case report of embolized umbilical venous catheter retrieval from the heart via femoral access in 660 g premature neonate. Radiology case reports. 2019 November;14(11):1415-1419. PubMed PMID: 31700556; PubMed Central PMCID: PMC6823817; DOI: 10.1016/j.radcr.2019.09.006.

Complete Rapp JP, Garrett MR. Will the real Dahl S rat please stand up?. American journal of physiology. Renal physiology. 2019 November 1;317(5):F1231-F1240. PubMed PMID: 31545925; PubMed Central PMCID: PMC6879929; DOI: 10.1152/ajprenal.00359.2019.

Complete Stevens MW, Rüedi-Bettschen D, Gunnell MG, Tawney R, West CM, Owens SM. Antibody production and pharmacokinetics of METH in rats following vaccination with the METH vaccine, IXT-v100, adjuvanted with GLA-SE. Drug and alcohol dependence. 2019 November 1;204:107484. PubMed PMID: 31521953; PubMed Central PMCID: PMC6878175; DOI: 10.1016/j.drugalcdep.2019.05.016.

Complete Hoang NH, Strogolova V, Mosley JJ, Stuart RA, Hosler J. Hypoxia-inducible gene domain 1 proteins in yeast mitochondria protect against proton leak through complex IV. The Journal of biological chemistry. 2019 November 15;294(46):17669-17677. PubMed PMID: 31591265; PubMed Central PMCID: PMC6873203; DOI: 10.1074/jbc.RA119.010317.

Complete Torres Fernandez ED, Huffman AM, Syed M, Romero DG, Yanes Cardozo LL. Effect of GLP-1 Receptor Agonists in the Cardiometabolic Complications in a Rat Model of Postmenopausal PCOS. Endocrinology. 2019 December 1;160(12):2787-2799. PubMed PMID: 31593246; PubMed Central PMCID: PMC6825516; DOI: 10.1210/en.2019- 00450.

Complete Warrington JP, Fan F, Duncan J, Cunningham MW, LaMarca BB, Dechend R, Wallukat G, Roman RJ, Drummond HA, Granger JP, Ryan MJ. The angiotensin II type I receptor contributes to impaired cerebral blood flow autoregulation caused by placental ischemia in pregnant rats. Biology of sex differences. 2019 December 11;10(1):58. PubMed PMID: 31829239; PubMed Central PMCID: PMC6907203; DOI: 10.1186/s13293-019- 0275-1.

Complete Eddy AC, Howell JA, Chapman H, Taylor E, Mahdi F, George EM, Bidwell GL 3rd. Biopolymer-Delivered, Maternally Sequestered NF-κB (Nuclear Factor-κB) Inhibitory Peptide for Treatment of Preeclampsia. Hypertension (Dallas, Tex. : 1979). 2020 January;75(1):193-201. PubMed PMID: 31786977; PubMed Central PMCID: PMC7008946; DOI: 10.1161/HYPERTENSIONAHA.119.13368.

Complete Showmaker KC, Cobb MB, Johnson AC, Yang W, Garrett MR. Whole genome sequencing and novel candidate genes for CAKUT and altered nephrogenesis in the HSRA rat. Physiological genomics. 2020 January 1;52(1):56-70. PubMed PMID: 31841396; PubMed Central PMCID: PMC6985787; DOI: 10.1152/physiolgenomics.00112.2019.

Complete Williams E, Chade AR. A Boolean Model of Microvascular Rarefaction to Predict Treatment Outcomes in Renal Disease. Scientific reports. 2020 January 16;10(1):440. PubMed PMID: 31949240; PubMed Central PMCID: PMC6965143; DOI: 10.1038/s41598-019-57386-8.

Complete Cook JE, Chandler C, Rüedi-Bettschen D, Taylor I, Patterson S, Platt DM. Changes in the elimination and resurgence of alcohol-maintained behavior in rats and the effects of naltrexone. Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors. 2020 February;34(1):10-22. PubMed PMID: 31750701; PubMed Central PMCID: PMC7007344; DOI: 10.1037/adb0000525.

Complete Deer EM, Welch B, Hernandez LL, Seeley RJ, Grayson BE. Nutrient and hormone composition of milk is altered in rodent dams post-bariatric surgery. Journal of developmental origins of health and disease. 2020 February;11(1):71-77. PubMed PMID: 31397254; PubMed Central PMCID: PMC6934892; DOI: 10.1017/S2040174419000424.

Complete Gulanski BI, Flannery CA, Peter PR, Leone CA, Stachenfeld NS. Compromised endothelial function in transgender men taking testosterone. Clinical endocrinology. 2020 February;92(2):138-144. PubMed PMID: 31765022; PubMed Central PMCID: PMC6957681; DOI: 10.1111/cen.14132.

Complete Itcho K, Oki K, Gomez-Sanchez CE, Gomez-Sanchez EP, Ohno H, Kobuke K, Nagano G, Yoshii Y, Baba R, Hattori N, Yoneda M. Endoplasmic Reticulum Chaperone

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Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production. Hypertension (Dallas, Tex. : 1979). 2020 February;75(2):492- 499. PubMed PMID: 31865789; PubMed Central PMCID: PMC7004827; DOI: 10.1161/HYPERTENSIONAHA.119.14062. Complete Hsieh CT, Lee YJ, Lee JW, Lu S, Tucci MA, Dai X, Ojeda NB, Lee HJ, Fan LW, Tien LT. Interleukin-1 receptor antagonist ameliorates the pain hypersensitivity, spinal inflammation and oxidative stress induced by systemic lipopolysaccharide in neonatal rats. Neurochemistry international. 2020 May;135:104686. PubMed PMID: 31987865; PubMed Central PMCID: PMC7078012; DOI: 10.1016/j.neuint.2020.104686.

C.2 WEBSITE(S) OR OTHER INTERNET SITE(S)

Nothing to report

C.3 TECHNOLOGIES OR TECHNIQUES

NOTHING TO REPORT

C.4 INVENTIONS, PATENT APPLICATIONS, AND/OR LICENSES

Have inventions, patent applications and/or licenses resulted from the award during the reporting period? No

If yes, has this information been previously provided to the PHS or to the official responsible for patent matters at the grantee organization?

C.5 OTHER PRODUCTS AND RESOURCE SHARING

Nothing to report

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