DOCSLIB.ORG

Association Between Osteosarcopenic Obesity and Hypertension Among Four Minority Populations in China: a Cross- Sectional Study

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Association Between Osteosarcopenic Obesity and Hypertension Among Four Minority Populations in China: a Cross- Sectional Study Open access Research BMJ Open: first published as 10.1136/bmjopen-2018-026818 on 18 July 2019. Downloaded from Association between osteosarcopenic obesity and hypertension among four minority populations in China: a cross- sectional study Xingcai Chen,1 Cunqing Kong,1 Hongrong Yu,1 Jiangu Gong,1 Ling Lan,1 Lining Zhou,1 Jichun Gong,1 Peng Liu,1 Lin Xu,1,2 Qiongying Deng1,2 To cite: Chen X, Kong C, Yu H, ABSTRACT Strengths and limitations of this study et al. Association between Objective Osteosarcopenic obesity (OSO) may be osteosarcopenic obesity and associated with an increased prevalence of hypertension. ► To the best of our knowledge, this study is the first hypertension among four The aim of this study was to examine the difference in the minority populations in China: a to explore the association between osteosarcopenic prevalence of OSO and hypertension among four minority cross-sectional study. BMJ Open obesity (OSO) and hypertension by sex among mi- populations in China and explore the relationship between 2019;9:e026818. doi:10.1136/ nority groups in China. OSO and hypertension by sex. bmjopen-2018-026818 ► This study is based on the four minority populations Design This study adopted a cross-sectional design. in China, and these groups are regarded as isolated ► Prepublication history for Participants In total, 1939 participants aged ≥50 years, populations because of intraethnic marriages. this paper is available online. including 459 Jing, 514 Maonan, 535 Hmong and 431 Yao To view these files please visit ► The cross-sectional design of this study prevented participants from Guangxi Province, China, were included the journal online (http:// dx. doi. us from drawing any causal inferences about the using stratified cluster random sampling. org/ 10. 1136/ bmjopen- 2018- potential effect of OSO on hypertension. 026818). Main outcome measures The body composition, bone mineral density and blood pressure were measured by XC and CK contributed equally. an MC-180 body composition analyser, Achilles Express ultrasound bone densitometer and OMRON HEM-1000 that osteoporosis, sarcopenia and obesity are Received 22 September 2018 electronic sphygmomanometer, respectively. Revised 11 April 2019 interconnected through a common patho- Results The results showed that 65.77% of Hmong men, 2 3 http://bmjopen.bmj.com/ Accepted 30 May 2019 physiology. 58.79% of Hmong women, 54.82% of Maonan men, 50.00% of Maonan women, 41.92% of Jing men, 45.21% Therefore, the concept of osteosarcopenic of Jing women, 53.66% of Yao men and 42.32% of Yao obesity (OSO) syndrome was established in women suffered from hypertension. Compared with those the scientific literature to better understand among the normal group, the adjusted OR and 95% CI of the association between the changes in body age among the women with OSO was 3.15 (1.13 to 8.78). composition and certain chronic diseases. After adjusting for age, ethnicity, smoking status, alcohol OSO is a newly identified condition char- consumption, physical activity and menopausal status, the acterised by the concurrent occurrence of women with OSO also had a higher OR (OR=3.18, 95% CI sarcopenia, osteoporosis and obesity.4 Each on September 28, 2021 by guest. Protected copyright. 1.14 to 8.88) for hypertension than those in the normal © Author(s) (or their of these three conditions is associated with employer(s)) 2019. Re-use group. However, the ORs (95% CI) for hypertension in men permitted under CC BY-NC. No with one or more components were not significant after common complications, such as fragility frac- 5 commercial re-use. See rights adjusting for age and ethnicity. tures. In combination, sarcopenia, osteopo- and permissions. Published by Conclusion These results suggest that OSO is a risk rosis and obesity are considered to be related BMJ. factor for hypertension, especially in women. Furthermore, to worse events than each condition alone.1 2 1 Department of Human Anatomy, the prevalence of OSO and hypertension in the present Hypertension, which is a multifactorial Guangxi Medical University, study displayed sex-specific and ethnic-specific Nanning, China disease involving environmental and genetic differences among the four minority populations. 2Guangxi Colleges and factors and risk-conferring behaviours, Universities Key Laboratory remains the most common chronic disease of Human Development and worldwide.6 7 Doumas et al noted that cardio- Disease Research, Guangxi Medical University, Nanning, INTRODUCTION vascular morbidity and mortality present some China Ageing can be accompanied by unfavourable differences between male and female hyper- 8 changes in body composition, such as low tensive patients. According to Regitz-Zagro- Correspondence to bone mass (osteoporosis), decreased muscle sek’s report, hypertension is more common Professor Lin Xu; mass and strength (sarcopenia) and increased in women than men in the elderly popu- 280840607@ qq. com and 9 Professor Qiongying Deng; adiposity (obesity), especially in older lation. However, one study conducted in dengqy@ gxmu. edu. cn women.1 Numerous studies have suggested Nepal showed that prehypertension and Chen X, et al. BMJ Open 2019;9:e026818. doi:10.1136/bmjopen-2018-026818 1 Open access BMJ Open: first published as 10.1136/bmjopen-2018-026818 on 18 July 2019. Downloaded from hypertension occurred more frequently in males than protocol in each village. All participants provided written famales.10 informed consent prior to participation in this study. According to one study conducted by Liu et al, Y-STR haplotypes in minority populations in Guangxi are highly Measures polymorphic and have high discriminatory power.11 These Height was measured by an altimeter with the participants minority populations have been regarded as isolated popu- standing barefoot. The circumferences of the waist and lations.12 However, due to limited financial and human hips were measured with an inelastic measuring tape with resources, we conducted a survey involving only Hmong, the participants in their underwear. The waist-to-hip ratio Maonan, Jing and Yao populations. The Jing, Maonan, (WHR) was defined as the waist circumference divided by Hmong and Yao populations are isolated minority groups the hip circumference. All length indexes were measured in the Guangxi Zhuang Autonomous Region, China. to the nearest 0.1 cm. The Jing population is the only oceanic ethnic group in The body composition was measured with a bioelectric China, and a very small minority population of 28 199 impedance analysis. The MC-180 body composition anal- was reported in 2010.13 Compared with the Jing popu- yser, which was manufactured by the Japanese TANITA, lation, the Maonan, Hmong and Yao groups reportedly has high sensitivity and specificity and was adjusted daily had slightly larger populations of 101 192 (0.0076%), before the measurements to minimise measurement 9 426 007 (0.7072%) and 2 796 003 (0.2098%), respec- errors. The participants were instructed to fast, refrain tively, in 2010.14 In addition, their special customs and from strenuous exercise for 4 hours or more and refrain culture, including their clothing, intraethnic marriages, from drinking for 1 hour before testing. Any metal items dietary habits and lifestyle factors, differ among the were removed from the participants to ensure the accu- groups and especially from Han Chinese.15–17 However, racy of the measures prior to the measurement. The knowledge regarding the differences in the prevalence of participants were positioned on the analyser’s surface hypertension and association between OSO and hyper- barefoot according to the manufacturer’s specifications. tension among these minority groups is limited. The body composition indexes included the body mass The aim of this study was to examine the difference index (BMI), percentage of body fat (PBF), fat-free in the prevalence of OSO and hypertension in the four mass (FFM), fat mass (FM) and appendicular lean mass minority groups in Guangxi and explore the relationship (ALM). The BMI was calculated as the weight divided by between OSO and hypertension by sex. the square of the height (kg/m2). PBF was calculated as the proportion of FM to the total body weight. ALM was calculated as the sum of the arm and leg lean mass. All mass indexes were measured to the nearest 0.1 kg. METHODS Quantitative ultrasound bone density measurements http://bmjopen.bmj.com/ Study design and participants of the right calcaneus were performed in all participants This study adopted a cross-sectional design and was using an Achilles Express ultrasound bone densitom- funded by the National Natural Science Foundation of eter (GE, USA); the parameters included the speed of China. Ethical approval was provided by the Medical sound (SOS), broadband ultrasound attenuation (BUA) Ethics Committee of Guangxi Medical University. In and stiffness index (SI). The SI was calculated automat- this study, the following inclusion criteria were used: (1) ically by the system software according to the following participants aged ≥50 years; (2) men and non-pregnant formula: SI=(0.67×BUA+0.28 ×SOS)–420.18 The T-score women and (3) healthy adults without a history of frac- was calculated based on the normal reference value of on September 28, 2021 by guest. Protected copyright. tures or major diseases. Correspondingly, the following BMD in a young and healthy population and matched exclusion criteria were used: (1) a history of traumatic by gender and ethnic group. According to the WHO fractures or serious metabolic, cardiovascular or endo- criteria,19 the BMD was classified into the following three crine diseases; (2) pregnant or lactating women and (3) categories: osteoporosis based on a T-score value of −2.5 the use of medications that may affect bone metabolism, or lower; osteopenia based on a T-score value between including statins, glucocorticoids, thiazolidinediones and −1.0 and −2.5 and normal bone mass based on a T-score antiepileptic medications. value above −1.0.
Load more

Recommended publications
  • Explorations in Semantic Parallelism
    Explorations in Semantic Parallelism Explorations in Semantic Parallelism James J. Fox Published by ANU Press The Australian National University Canberra ACT 0200, Australia Email: [email protected] This title is also available online at http://press.anu.edu.au National Library of Australia Cataloguing-in-Publication entry Author: Fox, James J, 1940 - author. Title: Explorations in semantic parallelism / James J. Fox. ISBN: 9781922144690 (paperback) 9781925021066 (ebook) Subjects: Semantics. Parallelism (Linguistics) Dewey Number: 401.43 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying or otherwise, without the prior permission of the publisher. Cover design by Nic Welbourn and layout by ANU Press Printed by Grifn Press This edition © 2014 ANU Press Contents Acknowledgments ..................................vii Dedication ....................................... xi Comparative Issues 1. Introduction ...................................3 2. Roman Jakobson and the comparative study of parallelism .. 19 3. Trajectories in the continuing study of parallelism ........ 41 4. Semantic parallelism in Rotenese ritual language ......... 91 5. ‘Our ancestors spoke in pairs’ ..................... 129 6. On binary categories and primary symbols ............ 149 7. Category and complement ....................... 181 8. Exploring oral formulaic language .................. 201 The Traditional Oral Canon 9. Genealogies of the Sun and Moon .................. 219 10. Manu Kama’s road, Tepa Nilu’s path ................ 229 11. Genealogy and topogeny ........................ 265 12. Blood-red millet: An origin narrative ................. 277 13. Admonitions of the ancestors: Giving voice to the deceased .............................. 283 14. To the aroma of the name: The celebration of a ritual of rock and tree .............................. 295 The Christian Oral Canon 15.
    [Show full text]
  • CDISC CDASH Controlled Terminology, 2020-05-08
    CDISC CDASH Controlled Terminology, 2020-05-08 Source: NCI EVS Terminology Resources website: http://www.cancer.gov/cancertopics/cancerlibrary/terminologyresources/cdisc NCI CDISC Submission Codelist Name CDISC Definition Codelist Code Value Extensible C78418 CMDOSFRM Concomitant A terminology subset of the CDISC SDTM Pharmaceutical Dosage Form Yes Medication Dose Form codelist created for CDASH Concomitant Medication Dose Form codelist. (NCI) C78419 CMDOSFRQ Concomitant A terminology subset of the CDISC SDTM Frequency codelist created for Yes Medication Dosing CDASH Concomitant Medication Dosing Frequency per Interval codelist. Frequency per (NCI) Interval C78417 CMDOSU Concomitant A terminology subset of the CDISC SDTM Unit codelist created for CDASH Yes Medication Dose Units Concomitant Medication Dose Units codelist. (NCI) C78420 CMROUTE Concomitant A terminology subset of the CDISC SDTM Route codelist created for CDASH Yes Medication Route of Concomitant Medication Route of Administration codelist. (NCI) Administration C78421 DAORRESU Unit of Drug A terminology subset of the CDISC SDTM Unit codelist created for CDASH Yes Dispensed or Unit of Drug Dispensed or Returned codelist. (NCI) Returned C78422 EGORRESU ECG Original Units A terminology subset of the CDISC SDTM Unit codelist created for CDASH Yes ECG Original Units codelist. (NCI) C128690 ETHNICC Ethnicity As Collected A terminology codelist relevant to the ethnicity of an individual as collected Yes on the case report form. C78426 EXDOSFRM Exposure Dose Form A terminology subset of the CDISC SDTM Pharmaceutical Dosage Form Yes codelist created for CDASH Exposure Dose Form codelist. (NCI) C78745 EXDOSFRQ Exposure Dosing A terminology subset of the CDISC SDTM Frequency codelist created for Yes Frequency per CDASH Exposure Dosing Frequency per Interval codelist.
    [Show full text]
  • Original Article Sexually Dimorphic Association of the B-Cell CLL/Lymphoma 7B Gene Rs2237278 and Lipid-Associated Phenotypes
    Int J Clin Exp Pathol 2016;9(12):12942-12958 www.ijcep.com /ISSN:1936-2625/IJCEP0035189 Original Article Sexually dimorphic association of the B-cell CLL/lymphoma 7B gene rs2237278 and lipid-associated phenotypes Tao Guo, Rui-Xing Yin, Hui Gao, Qing-Hui Zhang, Jian-Hua Huang, Wei-Jun Li Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China Received July 6, 2016; Accepted July 20, 2016; Epub December 1, 2016; Published December 15, 2016 Abstract: The biology basis for gender differences in cardiovascular diseases (CVDs) susceptibility seems ubiquitous especially for postmenopausal women, but little is known about the sexually dimorphic association of the B-cell CLL/lymphoma 7B gene (BCL7B) rs2237278 single nucleotide polymorphism (SNP) and environmental factors with lipid profiles in the Jing and Han populations. To study the contribution of BCL7B rs2237278 to both the establish- ment and persistence of gender differences in lipid profiles, genotyping was performed in 1148 of Jing (582 males and 566 females) and 1355 of Han (706 males and 649 females) participants using polymerase chain reaction and restriction fragment length polymorphism. Sexually dimorphic analysis showed that the genotype and allele frequencies of the BCL7B rs2237278 SNP were significantly different between males and females in Jing (CC, 67.87% vs. 61.31%; CT, 29.55% vs. 34.63%; TT, 2.58% vs. 4.06%; P = 0.047; T, 17.35% vs. 21.38%, P = 0.015) and Han populations (CC, 68.27% vs. 62.10%; CT, 29.32% vs. 34.36%; TT, 2.41% vs.
    [Show full text]
  • Religions & Christianity in Today's
    Religions & Christianity in Today's China Vol. XI 2021 No. 3 Contents Editorial | 2 News Update on Religion and Church in China March 16 – July 6, 2021 | 3 Compiled by Katharina Feith, Isabel Friemann (China InfoStelle), Katharina Wenzel-Teuber and Jan Kwee, with a contribution by Willi Boehi Christian Life among the Lisu in Yunnan Province | 20 Y. Franklin Ishida Book Review of: Gail King, “A Model for all Christian Women”. Candida Xu, a Chinese Christian Woman of the Seventeenth Century, Collectanea Serica, New Series 2, Abingdon, Oxon – New York – Sankt Augustin: Routledge – Monumenta Serica Institute 2021 | 32 Leopold Leeb Imprint – Legal Notice | 38 Religions & Christianity in Today's China, Vol. XI, 2021, No. 3 1 Editorial Dear Readers, With this number we today present to you the third 2021 issue of Religions & Christianity in Today’s China (中国宗教评论). The issue includes the regular series of News Updates on recent events and general trends with regard to religions and especially Christianity in today’s China. Rev. Dr. Y. Franklin Ishida, Director for Asia and the Pacific of the Evangelical Lutheran Church in America, in his article “Christian Life among the Lisu in Yunnan Province” gives a most interesting insight into this ethnic group. 70 percent of the appoximately 750,000 Lisu in Yuannan Province are Christian. This issue closes with a book review by Prof. Dr. Leo Leeb, Renmin University in Bei- jing, of Gail King, “A Model for all Christian Women”. Candida Xu, a Chinese Christian Woman of the Seventeenth Century, edited at Monumenta Serica Institute, describing this outstanding “creatively thinking missionary from the upper class.” Religions & Christianity in Today’s China is freely available on the website of the China- Zentrum, www.china-zentrum.de.
    [Show full text]
  • Original Article Association of the BTNL2 Rs9268480 SNP and Several Environmental Factors with Serum Lipid Profiles in the Jing and Han Populations
    Int J Clin Exp Pathol 2016;9(12):12686-12700 www.ijcep.com /ISSN:1936-2625/IJCEP0030138 Original Article Association of the BTNL2 rs9268480 SNP and several environmental factors with serum lipid profiles in the Jing and Han populations Tao Guo, Rui-Xing Yin, Xia Chen, Ling Pan, Yuan Bin, Wu-Xian Chen Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China Received April 8, 2016; Accepted June 13, 2016; Epub December 1, 2016; Published December 15, 2016 Abstract: Hyperlipidemia-related mechanisms have been associated with damage to the cardiovascular disease (CVD). Here, we discuss potential explanations for the higher prevalence of hyperlipidemia in the Jing and Han populations. Although genetic and environmental factors are the triggers, the search for the ethnic and gender related factors that explain the increased susceptibility of hyperlipidemia is a promising area for research. Ethnicity and gender differences could be the major confounding variable to prove genetic associations. Despite that, we investigated the ethnic and sex-specific association between the butyrophilin-like 2 gene (BTNL2) rs9268480 single nucleotide polymorphism (SNP) and several environmental factors with serum lipid profiles in the Jing and Han pop- ulations. Genotypes of the rs9268480 SNP, clinical and biochemical measurements were characterized in a total of 2503 subjects (1148 Jing and 1355 Han). Jing populations had higher serum total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) levels and lower apolipoprotein (Apo) A1 levels and the ratio of ApoA1 to ApoB than in Han. The frequency of susceptibility alleles of rs9268480 C > T were significantly different between the two populations (20.86% vs.
    [Show full text]
  • Explorations in Semantic Parallelism
    Explorations in Semantic Parallelism Explorations in Semantic Parallelism James J. Fox Published by ANU Press The Australian National University Canberra ACT 0200, Australia Email: [email protected] This title is also available online at http://press.anu.edu.au National Library of Australia Cataloguing-in-Publication entry Author: Fox, James J, 1940 - author. Title: Explorations in semantic parallelism / James J. Fox. ISBN: 9781922144690 (paperback) 9781925021066 (ebook) Subjects: Semantics. Parallelism (Linguistics) Dewey Number: 401.43 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying or otherwise, without the prior permission of the publisher. Cover design by Nic Welbourn and layout by ANU Press Printed by Griffin Press This edition © 2014 ANU Press Contents Acknowledgments . vii Dedication . xi Comparative Issues 1 . Introduction . 3 2 . Roman Jakobson and the comparative study of parallelism . 19 3 . Trajectories in the continuing study of parallelism . 41 4 . Semantic parallelism in Rotenese ritual language . 91 5 . ‘Our ancestors spoke in pairs’ . 129 6 . On binary categories and primary symbols . 149 7 . Category and complement . 181 8 . Exploring oral formulaic language . 201 The Traditional Oral Canon 9 . Genealogies of the Sun and Moon . 219 10 . Manu Kama’s road, Tepa Nilu’s path . 229 11 . Genealogy and topogeny . 265 12 . Blood-red millet: An origin narrative . 277 13 . Admonitions of the ancestors: Giving voice to the deceased . 283 14 . To the aroma of the name: The celebration of a ritual of rock and tree . 295 The Christian Oral Canon 15 .
    [Show full text]
  • List of Ethnic Groups in China and Taiwan
    List of ethnic groups in China and Taiwan Multiple ethnic groups populate China, where "China" is taken to mean areas controlled by either of the two states using "China" in their formal names, the People's Republic of China (China) and the Republic of China (Taiwan). The Chinese people refers to the Han 漢 people which is often misunderstood as Han Chinese, are the largest ethnic group, where (as of 2010) some 91.51%[1] of the population was classified as Han (~1.2 billion). Han is the name the Chinese have used for themselves since the Han Dynasty BC 202, whereas the name "Chinese" (used in the West) is of uncertain origin, but possibly derives ultimately from Sanskrit Cina-s "the Chinese," perhaps from the Qin dynasty. Besides the Chinese majority, 55 other ethnic groups are categorized in present China by the PRC communist, numbering approximately 105 million people, mostly concentrated in the bordering northwest, north, northeast, south, and southwest but with some in central interior areas. The major minority ethnic groups in China are Zhuang (16.9 million), Hui (10.5 million), Manchu (10.3 million), Uyghur (10 million), Miao (9.4 million), Yi (8.7 million), Tujia (8.3 million), Tibetan (6.2 million), Mongol (5.9 million), Dong (2.8 million), Buyei (2.8 million), Yao (2.7 million), Bai (1.9 million), Korean (1.8 million), Hani (1.6 million), Li (1.4 million), Kazakh (1.4 million), and Dai (1.2 million).[2] Contents Ethnic groups recognized by the People's Republic of China Taiwanese aborigines "Undistinguished" ethnic minority groups
    [Show full text]
  • The Narrative Arts of Tianjin: Between Music and Language 1St Edition Pdf
    FREE THE NARRATIVE ARTS OF TIANJIN: BETWEEN MUSIC AND LANGUAGE 1ST EDITION PDF Francesca R Sborgi Lawson | 9781351885324 | | | | | - Document - Francesca R. Sborgi Lawson: The Narrative Arts of Tianjin: Between Music and Language Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Recent scholarship in the field of music cognition suggests the need for increased interdisciplinarity in moving beyond the boundaries of Western European music, and the study of the relationship between language and music is an especially fruitful area that can benefit from interdisciplinary collaboration. This paper heeds the call for collaborative research in cultures outside of Western Europe by focusing on Xiangshenga form of Chinese musical comedy that features an intriguing relationship between speech and song in performance. The Narrative Arts of Tianjin: Between Music and Language 1st edition present The Narrative Arts of Tianjin: Between Music and Language 1st edition argues that analytical tools and perspectives from conversational analysis, communicative musicality, empirical research on music-language relationships, and performative mutuality in ethnomusicology all speak to the idea of musicality —the underlying capacity that undergirds our ability to communicate both verbally and musically —as a common foundational behavior in both speech and song. Musicality is particularly apparent in the way Chinese Xiangcheng actors relate to each other and their audiences in both spoken and musical modalities, and this paper suggests how judiciously employing a variety of methodological approaches in the study of musicality can yield important insights for researchers from all disciplines.
    [Show full text]