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GFS Organics Modern Acetylene Chemistry for Research and Applied Technology ORDERING INFORMATION GFS ORGANIC® CHEMICALSGFS Organics Modern Acetylene Chemistry for Research and Applied Technology ORDERING INFORMATION Customer Service Representatives and Technical Support are available Monday through Friday from 8:00 a.m. to 5:30 p.m. Eastern Time. Orders may be placed by mail, phone, fax, e-mail or on our web site. Every order receives an order confirmation sent via fax or e-mail that includes items ordered, pricing, shipping method, and estimated shipping date. By Mail: GFS CHEMICALS, INC. 800 Kaderly Drive Columbus, OH 43228 By Phone: 800-858-9682 (U.S. and Canada) (740) 881-5501 (International) By Fax: (740) 881-5989 By E-mail: [email protected] For Applied Technologies, R&D, or Pilot Scale email: [email protected] On the Web: www.gfschemicals.com www.gfsinternational.com Opening an account GFS Customer Service Representatives will be glad to help you open an account. For details call: 1-800-858-9682. (740) 881-5501 (International) For full terms and conditions visit http://www.gfschemicals.com/statics/ documents/aboutus/termsandconditions.html Notice: GFS products are not certified or intended for direct use in food, drug, or cosmetic applications; they are warranted to meet our specifica- tions as given in GFS Lot Analysis or other Company literature. Determi- nation of material suitability and/or merchantability for purposes beyond these specifications is the responsibility of the end user. We Honor WHY SOURCE FROM GFS? GFS is recognized as a world Customers benefit from our A Sampling of Our Core leader in the production of knowledge and expertise Organic Chemistries alkynes and downstream in the formulation of spe- derivative technology. Using cialties derived from liquid • Acetylene Chemistry our core synthetic chemis- ammonia chemistries. These • Halogenation tries, we build upon our al- include acetylide couplings, • Dehydrohalogenation kyne base to make thousands alkali metal/amide reactions, • Alkylation(NH3) of specialty alkynes, olefins, isomerizations, Birch reduc- • Sonogashira Reactions silanes, halogenated organ- tions, Grignard reactions, and • Kumada Couplings ics, Grignards and heteroaro- organolithium chemistries • Cadiot-Chodkiewicz matics. We can supply bulk and more. • Suzuki Coupling quantities of organic products • Trans Reductions(NH3) from multi-kilo to metric tons. • Diels-Alder Synthesis Contact us anytime with • Ethynylation questions or requests via • Barbier Reaction Development@gfschemicals. • Skraup Synthesis com. • Birch Reduction • Heck Reaction • Grignard/Alkyl Lithium Synthesis • Finkelstein Reaction • Phase Transfer By working with the manufac- turer you can take advantage of our network for: sourcing, pricing & applied technologies 1 ACETYLENE CHEMISTRY ACETYLENE REACTIONS GFS Chemicals manufactures Our 80 years of history and Many of the products we the widest range of strategic acquisitions have offer are, in turn, used to specialty acetylenic expanded this product group support additional down compounds in the U.S. through the addition of some stream chemistry – aldehydes unique chemical synthesis to make secondary alcohols, Many aspects of “molecular and our buying power tied to alcohols to make haloge- construction” are being dra- the support of our manufac- nated compounds, ketones matically enhanced through turing operations. to make tertiary alcohols and the use of both simple and amines to support a host multifunctional acetylenic of chemistries as an acid building blocks. scavenger, buffer media or in the production of more The GFS handbook, “GFS functional amines. GFS not Organics Modern Acetylene only offers these for sale but Chemistry for Research and as you focus on our other Applied Technology”, is a core product offerings we’re valuable resource which puts confident you’ll see how we information on properties and integrate our product listings availability of several hundred and chemistry capabilities to specialty and exotic acetyle- focus on the vertical integra- nic and olefinic compounds tion of our business. at every researcher’s fingertips. Acetylene Reactions HC CR HC CC2OH HC CCnCl HC CH HC CC C CH RC CC CCOH 2 n ALKYNE REACTIONS Acetylene derivatives With this came the addition (alkynes) are the back bone to of liquid ammonia chemistry the GFS organic product line. as a reaction media as well The acquisition of Farchan as helped further expand our Laboratories (Gainsville, FL) work in the area of in the mid-1990’s added over Sonogashira chemistry 400 core alkynes to our among other palladium (Pd) product list. catalyzed coupling reactions. The use of trimethylsilylacety- lene (TMSA, TMS Acetylene) 3 and phenylacetylene has become a base chemistry platform for several on-going projects as well as new development projects and alternative chemistry routes for existing products. Alkynes have become core building blocks for several other functionalized products such as our specialty olefins, diactylenic intermediates and specialty heterocycles, to name a few. We estimate that alkyne chemistry is respon- sible for approximately 15% of all R&D work today. The growing number of literature references that use acetyle- nic intermediates in organic synthesis demonstrates the impact this chemical fam- ALKYNES ily continues to have on the research community from O ® “Click Chemistry” used to R C R CC(O)R’ assemble complex hetero- H aromatics and other hetero- O cycles to the construction R C of chromophores. R CC R OR’ O R C R CC H R CC R’ O H OH R COH R CC R CC C C X n m R CC CnX 4 GFS Chemicals - LIQUID AMMONIA Liquid Ammonia Chemistry REACTIONS Technology Advancements R R’ R’ R R R’ R CC H NH N R N 2 H R” NH CH Cn 3 Z n = 2-7 R C C R’ R C C CH2OH R CC N 5 GRIGNARDS For more than 100 years, Our focus remains on the customers save reactor the chemistry of Grignard specialty Grignards that stem space and time in their reagents (R-Mg-X) has been from our existing product manufacturing facilities. known for use as highly ver- lines: satile tools for building carbon It also opens up the skeletons of complex organic • Alkyl Grignards (t-butyl opportunity to go deeper molecules. What were origi- MgBr, isopropyl MgBr, with our customer base and nally handled as products for octyl MgCl, etc.) provide the next step in their captive use only, GFS made a • Alkynyl Grignards (ethynyl chemistry if interested. Our conscious decision to sup- MgCl, propynyl MgBr, expanding Grignard line is port our customer base by heptynyl MgCl, etc.) available in bulk, typically offering specialty Grignards • Olefinic Grignards made on demand and for research and commercial (isopropenyl MgBr, Hexenyl delivered in a timely manner. needs. Although not a com- MgBr, Octenyl MgCl, etc.) We also offer our customers modity Grignard producer, • Aryl Grignards (phenyl GFS has the plant capacity to MgCl, 4-benzyloxyphenyl support specialty Grignards MgBr, 4-chlorophenyl MgBr) from lab scale through container volumes. GFS Grignards can be supported in several solvents ranging from THF, butyl ether, methyl THF, diethyl ether, etc. Our ability to manufacture these internally helps our 6 the unique option of purchas- This includes: Can’t find what you are look- ing Grignards in cylinders. ing for? Need a special con- Cylinders can offer improved • Anhydrous solvents for centration or solvent? Please methods of transfer that Grignard reactions allow GFS Chemicals, Inc. to increase plant safety and help evaluate your request for a maintain product quality. • Elemental magnesium and custom product. With our background in iodine to support production Organic and Inorganic Manu- of Grignard reagents facturing, GFS also offers several supporting products • Anhydrous cerium (III) for Grignard chemistry. chloride for Grignard initiation and organic reactions Visit GFSorganics.com for more information on support for process chemistry 7 ORGANOMETALLIC Organometallic compounds rent industrial and academic CHEMISTRY provide a source of nucleo- purposes. philic carbon atoms which can react with electrophilic We always welcome the carbon to form a new carbon- opportunity to provide carbon bond. This is very additional organometallic important for the synthesis chemicals, particularly within of complex molecules from our core areas, not currently simple starting materials. offered in our existing Organometallic compounds product lines. of Li, Mg (Grignard reagents) are amongst some of the Technology expertise in- most important organic re- cludes: agents. • Grignard In order to meet the needs of • Alkyl lithium our current (and future) cus- • Coupling (Suzuki, Stille, tomers, GFS Chemicals con- Negishi, Kumada) tinually strives to manufacture • Heck Reaction GFS supplies global industry and supply chemistries that • LI/NA Amide partners in electronics, are critically needed for cur- • Cis-reductions polymers and optics 8 The GFS catalog offers a window into our core manufacturing capabilities Organometallics (Mg, Li, Na) R—R’ Z E Ar—R (Ar) RCHO RMgX RLi RCCOH RC CR’ O R R’ CC CR R(CH2)nOTHP 9 HETEROAROMATIC CHEMISTRY For over 60 years GFS Chem- As such a large area of icals has supported a mixed product development we are bag of heteroaromatic com- finding heteroaromatic pounds. Until the acquisition compounds to be customer of Farchan Labs these were exclusive, creating a more largely focused on bipyridine, custom product driven phenanthroline and terpyri- environment and limiting our dine derivatives. direct exposure. We welcome your inquiries and offer a With the addition of over 400 good backbone
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