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2014-02-05 Expression Study Of Mycobacterium avium subspecies paratuberculosis Infected Cows – “A road to identify transcripts that could serve as biomarkers for early diagnosis of Johne’s disease”

David, Joel

David, J. (2014). Study Of Mycobacterium avium subspecies paratuberculosis Infected Cows – “A road to identify transcripts that could serve as biomarkers for early diagnosis of Johne’s disease” (Unpublished master's thesis). University of Calgary, Calgary, AB. doi:10.11575/PRISM/26265 http://hdl.handle.net/11023/1368 master thesis

University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. Downloaded from PRISM: https://prism.ucalgary.ca List of upstream regulators and their targets in differentially expressed at 9 months after infection © 2000-2013 Ingenuity Systems, Inc. All rights reserved. Upstream Regulator Fold Change Molecule Type Predicted Activation State Activation z-score p-value of overlap Target molecules in dataset HIF1A transcription regulator Inhibited -2.200 2.11E-01 ACO1,ATP2A2,CCR7,FHL3,NTRK2,SLC29A1 miR-1972 (miRNAs w/seed CAGGCCA) mature microRNA Inhibited -2.200 2.65E-01 C3orf45,FPGS,MAT1A,PRDX1,ZBTB33 simvastatin chemical drug Inhibited -2.184 3.28E-02 ACVR1,ANXA3,BAX,CCL3,NTRK2,STAT4 prednisolone chemical drug Inhibited -2.121 9.93E-03 ATG4A,BAX,GABARAPL1,PRDX1,RPS6KB1,SNCA,TNFSF10,UTRN miR-516a-3p (and other miRNAs w/seed GCUUCCU) mature microRNA Inhibited -2.000 6.09E-02 BTBD7,STAT4,SVOP,TTC37 miR-2115-5p (miRNAs w/seed GCUUCCA) mature microRNA Inhibited -2.000 8.01E-02 BTBD7,CLPTM1L,GCFC2,RPS6KB1 miR-544b (miRNAs w/seed CCUGAGG) mature microRNA -1.987 1.67E-01 CMTM3,CMTM7,UNC93A,UQCRFS1 POU5F1 transcription regulator -1.982 9.98E-03 ASH2L,JARID2,PHC1,SH3GLB1,STIM1 topotecan chemical drug -1.982 1.02E-01 FUBP1,MAP2K5,OSBPL8,PLK3 miR-4530 (miRNAs w/seed CCAGCAG) mature microRNA -1.964 3.33E-01 CYB5B,ERLIN2,OGDHL,RSAD1 miR-1827 (and other miRNAs w/seed GAGGCAG) mature microRNA -1.951 1.00E00 COBLL1,CXADR,SPDEF,SYT9 prostaglandin E2 chemical - endogenous mammalian -1.944 2.96E-01 BAX,CCL3,CCR7,FST,MXI1 sirolimus chemical drug -1.937 2.55E-01 BAX,CCR7,IL4R,LDHB,RPL15,RPS12,RPS6KB1 camptothecin chemical toxicant -1.800 6.07E-03 APPBP2,ARHGEF1,BAX,CCL3,CD53,CXCR5,FES,HLA-A,MAP2K5,MNAT1,OPTN,PIK3CA,TBL1X,TNK2,WNK1,ZNF408 miR-132-3p (and other miRNAs w/seed AACAGUC) mature microRNA -1.783 1.65E-02 ACVR1,BTBD7,CLYBL,COLQ,JOSD1,NFAT5,NREP,OSBPL8,SETD5,UBN1,VDAC2,VTI1A miR-16-5p (and other miRNAs w/seed AGCAGCA) mature microRNA -1.309 3.03E-02 AHCYL2,ARL3,C2orf43,C9orf69,CDK5RAP1,CHD9,COBLL1,CRIM1,DHDDS,ERLIN2,FUBP1,GABARAPL1,GORASP2,HECTD4,JARID2,KHNYN,LEPREL1,MAP1A,MTMR3,OOEP,RAPGEF2,RHOBTB2,SLC38A1,SOS2,STIM1,TIA1,VTI1A,ZBTB33 tacrolimus chemical drug -1.195 4.27E-03 ARHGEF1,BATF,BAX,CDK13,CXADR,NFAT5,PA2G4,TNFSF10 miR-486-5p (and other miRNAs w/seed CCUGUAC) mature microRNA -1.188 3.13E-02 CXCR5,MXI1,NFAT5,NUDCD1,SLC38A1,TBL1X,VTI1A miR-3197 (miRNAs w/seed GAGGCGC) mature microRNA -1.131 4.06E-02 CMTM3,FPGS,SIN3B,TMEM79 CD3 complex -1.122 1.06E-02 BATF,CCL3,CD5,CD53,GOLGB1,IL4R,LEF1,MST1,NFAT5,PA2G4,PDIA4,S100A11,STIM1,TNFSF10,VDAC2,YY1 miR-4708-5p (miRNAs w/seed GAGAUGC) mature microRNA -1.119 1.04E-02 ANXA3,ATF1,CSF2RA,FST miR-4428 (miRNAs w/seed AAGGAGA) mature microRNA -1.067 7.40E-03 BCDIN3D,CELF1,SCRN3,TMLHE miR-374b-5p (and other miRNAs w/seed UAUAAUA) mature microRNA -1.052 1.96E-03 ADNP,BTBD7,CHD9,CRIM1,CXADR,DIP2C,FECH,HECTD4,HEG1,MED13,MEF2D,PMEPA1,PNRC1,RAB5B,SCRN3,SETD2,UBAP2L,ZDHHC5,ZMYM1 TP73 transcription regulator -0.998 3.21E-02 BAX,ERCC2,IL4R,PNRC1,TBL1X,TRIM32 miR-3162-3p (miRNAs w/seed CCCUACC) mature microRNA -0.911 2.57E-02 ACVR1,GABARAPL1,OPTN,PHC1,S1PR1,SDHC miR-124-3p (and other miRNAs w/seed AAGGCAC) mature microRNA -0.883 4.21E-02 ARHGEF1,BTBD7,CDK13,CXADR,DDX6,DHDDS,FPGS,GPR173,LUC7L2,NFAT5,OSBPL8,PCSK6,PER3,PIK3CA,PMEPA1,PXMP4,RAB34,RAPGEF2,RPS6KB1,SART3,SH3GLB1,SLC29A1,SOS2,SSH1,TEX261,TIA1,TMLHE,TPCN1,TRABD,UBN1,WDR81,WNK1 miR-214-3p (and other miRNAs w/seed CAGCAGG) mature microRNA -0.883 2.34E-02 ATP2A2,BCDIN3D,CELF1,COLQ,ERLIN2,MICU1,MTMR3,NSD1,PPIP5K1,RAB34,RAB5B,RHOBTB2,RSAD1,SNCA,TNK2,UBAP2L,USP20,VTI1A miR-1321 (and other miRNAs w/seed AGGGAGG) mature microRNA -0.848 4.36E-02 AHCY,AHCYL2,HECTD4,MEF2D,MTMR3,NFAT5,SSH1,STIM1 XBP1 transcription regulator -0.816 1.50E-02 ATF6B,ATP2A2,Gkn3,GOLGB1,GORASP2,PDIA4,S1PR1 IL4 cytokine -0.806 4.76E-02 BAX,CCL3,CCR7,CD5,CXCR5,DGKA,EPHX1,IL4R,LEF1,PSMB8,PTPRCAP,SLC29A1,SMG7,STAT4,VTI1A miR-24-3p (and other miRNAs w/seed GGCUCAG) mature microRNA -0.781 2.36E-03 AGPAT1,ATG4A,CMTM3,CXADR,FST,GPR173,HEG1,MBD6,MEN1,MTMR3,MXI1,NFAT5,NREP,PHC1,PLK3,PMEPA1,PXMP4,RAB5B,S1PR1,VTI1A miR-3679-3p (miRNAs w/seed UUCCCCC) mature microRNA -0.722 2.42E-03 AUTS2,CHD9,DDX6,FST,FUBP1,GABARAPL1,PEBP1,PPP4R1,PRRC2A,SPDEF,SSTR2,TBL1X,TMLHE,TNFSF10,VTI1A miR-4652-5p (miRNAs w/seed GGGGACU) mature microRNA -0.670 1.57E-02 ATF6B,LPPR2,NSD1,PXMP4,RHOBTB2,SLC38A1,TIA1,VTI1A miR-155-5p (miRNAs w/seed UAAUGCU) mature microRNA -0.627 4.27E-02 C9orf69,CCL3,CHD9,FUBP1,JARID2,NFAT5,RAB34,S1PR1,TIA1,TRIM32,VTI1A,WNK1,YWHAE miR-4763-5p (miRNAs w/seed GCCUGCC) mature microRNA -0.608 1.29E-02 CXCR5,DHDDS,LPPR2,MICU1,NDUFA11,PCSK6,PLEKHG2,PRDX1,PXMP4,SIN3B,SSH1,SVOP,SYT9,TEX261 miR-495-3p (and other miRNAs w/seed AACAAAC) mature microRNA -0.579 2.04E-02 APPBP2,CELF1,CNR1,CRIM1,CYB5B,FUBP1,JOSD1,MPRIP,NFAT5,PLEKHG2,PNRC1,PRRC2A,SDHC,SLC25A26,SNCA,TEX261,UBN1,VDAC2,VPS13D,WNK1 miR-4308 (and other miRNAs w/seed CCCUGGA) mature microRNA -0.564 1.04E-02 AHCYL2,APPBP2,CELF1,NRBP2,PDIA4,PPIP5K1,SH3GLB1,SVOP,WDR81 IFN alpha/beta group -0.555 2.20E-02 BAX,CCR7,HLA-A,TNFSF10 miR-1225-3p (miRNAs w/seed GAGCCCC) mature microRNA -0.552 4.79E-02 APOBR,DDX6,GORASP2,MEF2D,SLC29A1,TEX261,UBN1,UNC93A,VTI1A miR-129-5p (miRNAs w/seed UUUUUGC) mature microRNA -0.529 1.52E-02 AUTS2,C9orf69,CELF1,MEF2D,MTMR3,PMEPA1,RHOBTB2,RPS6KB1,SNAPC3,SSH1,SSTR2,TBL1X,TNRC6C,ZBTB33 cyclosporin A biologic drug -0.529 2.67E-04 ARHGEF1,BATF,BAX,CCR7,CDK13,DGKA,FST,GSTM3,NFAT5,PA2G4,PSMB8,S100A11,TNFSF10,UTRN,VDAC2 miR-181a-5p (and other miRNAs w/seed ACAUUCA) mature microRNA -0.477 3.36E-02 AP1AR,ARL3,ATP2A2,CHD9,CNOT1,CNR1,CRIM1,CXADR,DIP2C,ERLIN2,JARID2,MAP1A,NFAT5,OSBPL8,PER3,RAPGEF2,RPS6KB1,S1PR1,SH3GLB1,SIN3B,TBL1X,WNK1,YY1,ZBTB33 gentamicin chemical drug -0.469 4.98E-03 ATIC,BAX,CDK13,HSPB1,Nrg1,PDIA4,PSMB8,SART3,SLC9A3 lenalidomide chemical drug -0.447 2.83E-02 AUTS2,BTBD7,CCL3,NUDCD1,UTRN miR-133a-3p (and other miRNAs w/seed UUGGUCC) mature microRNA -0.421 1.43E-02 AP1AR,ARL3,ATP2A2,CDK13,CELF1,CNOT1,GABARAPL1,GPR173,NFAT5,PPIP5K1,RAB34,SMPD4,SNCA,SVOP,SYT9,TBL1X,TTYH3 miR-3691-5p (miRNAs w/seed GUGGAUG) mature microRNA -0.339 2.03E-02 DNMBP,PLEKHG2,TIA1,ZNF274 BCL6 transcription regulator -0.339 2.51E-02 BAX,CCL3,CCR7,CXCR5,IL4R miR-27a-3p (and other miRNAs w/seed UCACAGU) mature microRNA -0.327 4.85E-02 ADD1,APPBP2,CNOT1,CNR1,COLQ,CXADR,GLT25D2,GPR173,HEG1,MED13,MFHAS1,MXI1,NFAT5,NGFRAP1,NREP,NSD1,PDIA5,PHF13,RAPGEF2,RPS6KB1,SFSWAP,SSH1,TIA1,WNK1 miR-149-5p (miRNAs w/seed CUGGCUC) mature microRNA -0.323 6.55E-03 ATP2A2,CD5,CMTM3,CYB5B,JOSD1,MTMR3,NFAT5,NSD1,NTRK2,OGDHL,PHC1,PPIP5K1,RHOBTB2,TBL1X,TEX261,TNK2 6-hydroxydopamine chemical toxicant -0.304 4.28E-03 ACO1,BAX,CNR1,MEF2D,SNCA miR-377-3p (miRNAs w/seed UCACACA) mature microRNA -0.254 2.99E-02 BTBD7,CELF1,CNR1,GPR173,MAP1A,MPRIP,MTMR3,NSD1,OGDHL,PDIA4,RPE,RPS6KB1,SETD5,STIM1,TBL1X miR-4323 (miRNAs w/seed AGCCCCA) mature microRNA -0.245 1.87E-02 AHCY,BCDIN3D,DHDDS,ME3,NRBP2,NSD1,SIN3B,STIM1 miR-873-5p (and other miRNAs w/seed CAGGAAC) mature microRNA -0.233 1.82E-03 AHCYL2,APPBP2,CRIM1,GOLGB1,LRRC41,PER3,PPP4R1,PXMP4,SDHC,SLC25A3,TIA1,WDR6,YWHAE miR-29b-3p (and other miRNAs w/seed AGCACCA) mature microRNA -0.232 4.76E-02 BTBD7,C16orf88,C9orf69,CNR1,DIP2C,ERLIN2,JARID2,JOSD1,MAT1A,NFAT5,NREP,NSD1,PER3,PHC1,SETD5,SH3GLB1,SYT9,USP34,WDR81,YWHAE,YY1,ZDHHC5 doxorubicin chemical drug -0.227 3.76E-02 ATP2A2,BAX,GSTM3,PMEPA1,PRDX1,PSMB8,S100A11,TNFSF10,UQCRFS1 miR-197-3p (and other miRNAs w/seed UCACCAC) mature microRNA -0.218 1.50E-02 ACVR1,CD53,CLYBL,DIP2C,ERLIN2,GOLGB1,RAB5B,SVOP,VTI1A EDN1 cytokine -0.182 3.06E-02 ATP2A2,CCR7,FST,MPRIP,Nrg1,YWHAE cisplatin chemical drug -0.172 2.49E-03 BAX,CD53,DGKA,GSTM3,IL4R,LDHB,MAT1A,MTMR3,NREP,PEBP1,PIK3CA,PLK3,PSMB8,RHOBTB2,S100A11,TNFSF10,TNK2 miR-3714 (miRNAs w/seed AAGGCAG) mature microRNA -0.132 4.87E-02 ADNP,CMTM7,PLEKHG2,TRIM32 miR-130a-3p (and other miRNAs w/seed AGUGCAA) mature microRNA -0.118 7.05E-03 ACVR1,BTBD7,C9orf69,CNR1,DDX6,DIP2C,ENPP5,HEG1,JARID2,PMEPA1,PNRC1,PXMP4,RAB34,RAB5B,S1PR1,SOS2,TEX261,TNRC6C,TTYH3,UBAP2L,VPS13D,WNK1 miR-590-3p (miRNAs w/seed AAUUUUA) mature microRNA -0.107 4.46E-02 ADD1,APPBP2,ARL3,AUTS2,C16orf88,CDK13,CHD9,CNR1,CYFIP1,ERLIN2,GOLGB1,HEG1,MED13,MMAA,NFAT5,OPTN,OSBPL8,PPP4R1,RPL15,SH3GLB1,TNRC6C,USP34,VTI1A,WNK1 miR-4687-5p (miRNAs w/seed AGCCCUC) mature microRNA -0.080 1.76E-02 MTMR3,PXMP4,SDHC,SYT9,WNK1 mono-(2-ethylhexyl)phthalate chemical toxicant 0.000 2.20E-02 ACO1,BAX,CASP8AP2,SDHC,TRIM41,UQCRFS1 STAT6 transcription regulator 0.074 6.29E-03 BAX,CCR7,DGKA,EPHX1,IL4R,S100A11,SPDEF,STAT4 miR-19b-3p (and other miRNAs w/seed GUGCAAA) mature microRNA 0.099 5.18E-05 ADNP,BTBD7,C9orf69,CDK13,CNR1,DDX6,ENPP5,GABARAPL1,HEG1,JARID2,LMBR1,MBD6,MED13,MEF2D,MPRIP,PHF13,PIK3CA,PLXNC1,PMEPA1,PNRC1,RAB34,RAB5B,RAPGEF2,S1PR1,SIN3B,TIA1,TNRC6C,TTYH3,UBAP2L,UBN1,VPS13D,VTI1A,WNK1 miR-455-5p (and other miRNAs w/seed AUGUGCC) mature microRNA 0.104 2.39E-02 ADNP,BCDIN3D,CDK13,MFHAS1,PLXNC1,PNRC1,S1PR1,TPCN1 miR-615-5p (and other miRNAs w/seed GGGGUCC) mature microRNA 0.145 2.79E-02 ATG2A,AUTS2,BATF,C2orf43,CD5,MICU1,NTRK2,PMEPA1,SSH1,TNRC6C,TTYH3 tretinoin chemical - endogenous mammalian 0.147 1.76E-02 ALDH3A1,ARHGEF1,ATP2A2,CCL3,CD53,CNR1,CSE1L,CXCR5,CYP2C18,EPHX1,FST,HSPB1,MAP2K5,MEF2D,MNAT1,MST1,NTRK2,OPTN,PLK3,PNRC1,RPS12,STAT4,TIA1,TNFSF10,TPCN1,WNK1,YWHAE miR-208a-3p (and other miRNAs w/seed UAAGACG) mature microRNA 0.208 4.37E-02 CHD9,CLYBL,COLQ,MED13,MTMR3,SOS2 TCR complex 0.222 1.23E-03 ARHGEF1,BATF,CCL3,CCR7,CD5,CDK13,CXCR5,IL4R,PA2G4,PDIA4,STAT4 miR-344d-3p (and other miRNAs w/seed AUAUAAC) mature microRNA 0.228 2.42E-02 APPBP2,ATF1,CDK13,NFAT5,NTRK2,PLEKHM2,PMEPA1,RAPGEF2,RHOBTB2,SH3GLB1,SLC25A3,TNRC6C,TTYH3,YY1,ZDHHC5 miR-3127-3p (miRNAs w/seed CCCCUUC) mature microRNA 0.234 1.36E-02 CELF1,DDX6,DUSP23,NFAT5,PCSK6,SSH1,TMLHE,WDR81 GSK3B kinase 0.261 2.58E-02 ATP2A2,BAX,SH3GLB1,TNFSF10 IFNA2 cytokine 0.282 2.70E-02 BAX,CCDC75,HLA-A,PHF11,STAT4,THEMIS2,TNFSF10 miR-92a-3p (and other miRNAs w/seed AUUGCAC) mature microRNA 0.305 1.13E-02 AP1AR,ATP2A2,CHD9,CNR1,CXADR,FHL3,GPR173,HEG1,JARID2,JOSD1,MEF2D,MFHAS1,NFAT5,PMEPA1,RPL15,S1PR1,SETD5,TIA1,TPCN1,WDR81,ZDHHC5 miR-1915-3p (miRNAs w/seed CCCAGGG) mature microRNA 0.341 4.56E-02 C9orf69,DNMBP,LRRC41,MEF2D,MICU1,MXI1,NDUFA11,SIN3B,STIM1,SVOP,TPCN1,TRIM11 miR-381-3p (and other miRNAs w/seed AUACAAG) mature microRNA 0.417 2.95E-06 ACVR1,APPBP2,ATP2A2,BAZ1B,BTBD7,CASP8AP2,CHD9,CNOT1,CYFIP1,DDX6,DIP2C,GABARAPL1,GORASP2,HECTD4,LEF1,MED13,NFAT5,NSD1,PNRC1,PRRC2A,RBM5,SLC38A1,SNCA,UBAP2L,UBN1,USP34,UTRN,WNK1,YY1,ZBTB33 miR-153 (and other miRNAs w/seed UGCAUAG) mature microRNA 0.437 3.79E-03 ADD1,ATP2A2,AUTS2,BTBD7,CDK13,EPC1,JARID2,JOSD1,MFHAS1,PHF13,PXMP4,RPS6KB1,SLC38A1,SNCA,SSH1,TIA1,TNRC6C,TPCN1,TTYH3,UTRN miR-1 (and other miRNAs w/seed GGAAUGU) mature microRNA 0.505 1.04E-02 ARL3,ASH2L,C3orf45,CRIM1,CYB5B,FUBP1,GCFC2,JARID2,JOSD1,LEF1,LMBR1,MAP1A,NFAT5,NSD1,OSBPL8,PLEKHG2,POLA2,RAPGEF2,SMG7,UBN1,UTRN DETA-NONOate chemical reagent 0.528 3.48E-03 ACO1,CCL3,DGKA,FPGS miR-502-5p (miRNAs w/seed UCCUUGC) mature microRNA 0.555 8.06E-03 APOBR,AUTS2,BABAM1,SVOP,SYT9 miR-4758-3p (miRNAs w/seed GCCCCAC) mature microRNA 0.566 3.50E-03 ADNP,ATP2A2,CCDC137,LEF1,MAP2K5,MXI1,NRBP2,NSD1,OGDHL,RHOBTB2,STIM1,TMLHE,TRIM11 miR-423-5p (and other miRNAs w/seed GAGGGGC) mature microRNA 0.602 2.14E-02 CMTM3,CMTM7,GPR173,MEF2D,NDUFA11,NRBP2,NSD1,PA2G4,RBM5,SIN3B,TPCN1,TRIM11,WDR81,WDYHV1 miR-3690 (miRNAs w/seed CCUGGAC) mature microRNA 0.612 1.23E-02 AHCYL2,CYP2C18,PHC1,RPL15,TNRC6C,WDR81 miR-30c-5p (and other miRNAs w/seed GUAAACA) mature microRNA 0.641 1.46E-02 ACVR1,ATF1,ATP2A2,BTBD7,CELF1,CHD9,DIP2C,JARID2,JOSD1,KHNYN,LMBR1,MBD6,MEF2D,MFHAS1,NFAT5,NREP,NSD1,OSBPL8,PER3,PHF13,PLXNC1,RAPGEF2,SETD5,SLC38A1,SSH1,TBL1X,TIA1,TNRC6C,UBN1 miR-148b-3p (and other miRNAs w/seed CAGUGCA) mature microRNA 0.647 1.19E-02 ACVR1,ATP2A2,CDK13,CHD9,CNR1,DDX6,HLA-A,JARID2,LRRC41,MPRIP,NFAT5,NSD1,RAB34,S1PR1,SOS2,TNRC6C,UBAP2L,ZNF274 miR-149-3p (and other miRNAs w/seed GGGAGGG) mature microRNA 0.693 3.04E-02 AGPAT1,CCR7,CXCR5,GPR173,MEF2D,MOB3A,PA2G4,PMEPA1,PXMP4,RAB5B,RBM5,SLC29A1,SMPD4,STIM1,TPCN1,TRABD,TTYH3,ZBTB33 let-7a-5p (and other miRNAs w/seed GAGGUAG) mature microRNA 0.742 1.63E-02 APPBP2,ATP2A2,CCL3,CCR7,CHD9,CHMP2A,DUSP23,HECTD4,KHNYN,MARCH9,MEF2D,MTMR3,NSD1,PLXNC1,PRRC2A,RPP38,SLC38A1,SSH1,TEX261,TIA1,TNFSF10,TRABD,TRIM41,USP20,UTRN miR-4727-3p (miRNAs w/seed UAGUGGG) mature microRNA 0.762 3.21E-02 APPBP2,NTRK2,PA2G4,PSMB8 miR-3150a-3p (miRNAs w/seed UGGGGAG) mature microRNA 0.812 3.04E-02 ACVR1,FHL3,MAP1A,OPTN,PA2G4,RAB5B,STIM1,XAB2,YWHAE ionomycin chemical reagent 0.870 2.20E-02 CCL3,DGKA,JARID2,NFAT5,TNFRSF6B,TNFSF10 MYCN transcription regulator 0.896 1.36E-02 BAX,CRIM1,HLA-A,JARID2,MXI1,PDIA4,RPS12,YY1 miR-2278 (miRNAs w/seed AGAGCAG) mature microRNA 0.900 3.10E-02 CRIM1,GOLGB1,GRB7,SLC38A1 IL12 (family) group 0.924 1.70E-02 CCL3,CXCR5,STAT4,TNFSF10 ethionine chemical toxicant 1.000 1.75E-03 MAT1A,PSMB8,S100A11,SLC25A3 miR-759 (miRNAs w/seed CAGAGUG) mature microRNA 1.000 8.33E-03 KHNYN,PEBP1,SART3,TEX261 miR-624-3p (miRNAs w/seed ACAAGGU) mature microRNA 1.000 8.33E-03 AP1AR,FST,NUDCD1,SLC38A1 mir-210 microRNA 1.000 2.39E-02 CASP8AP2,CDK10,CHD9,SETD2 miR-3619-3p (miRNAs w/seed GGACCAU) mature microRNA 1.000 3.44E-02 CD5,MARCH9,MED13,SYT9 miR-31-5p (and other miRNAs w/seed GGCAAGA) mature microRNA 1.015 1.98E-02 HLA-A,MPRIP,NFAT5,PLEKHG2,RAB5B,SIN3B,SSH1,TEX261,TIA1,UBN1,WNK1,YWHAE NOS2 enzyme 1.195 9.09E-03 ACO1,ALDH3A1,ATP2A2,BAX,CD53,TNFSF10,TNK2 etoposide chemical drug 1.231 4.36E-02 BAX,CCL3,PEBP1,RHOBTB2,TNFSF10 miR-3083-5p (and other miRNAs w/seed GGCUGGG) mature microRNA 1.248 3.66E-02 ACVR1,ARL3,C16orf88,C9orf69,CMTM3,FGD3,GPR173,MEN1,MOB3A,NDUFA11,NTRK2,PPIP5K1,SETD5,SIN3B,TPCN1 GnRH-A chemical reagent 1.342 2.71E-03 AGPAT1,CD53,FST,MNAT1,SNAPC3 miR-141-3p (and other miRNAs w/seed AACACUG) mature microRNA 1.354 1.88E-02 ACO1,APPBP2,ATP2A2,CDK13,CELF1,CHD9,CXADR,ENPP5,LMBR1,MPRIP,NUDCD1,NXPH2,RAPGEF2,SLC25A3,STAT4,TNRC6C,WDR81,YY1 miR-4640-3p (miRNAs w/seed ACCCCCU) mature microRNA 1.362 1.24E-02 ATF6B,BAX,MBD6,PEBP1,SETD5,TMEM79,WNK1 lipopolysaccharide chemical drug 1.538 2.98E-03 ACO1,ACVR1,ALDH3A1,ANXA3,ATP2A2,BAX,CCL3,CCR7,CD53,CSF2RA,DDX6,FES,FST,HLA-A,HSPB1,IGSF6,IL4R,MAP2K2,NFAT5,PCSK6,PDIA4,PLK3,PRDX1,PSMB8,PTPRCAP,S1PR1,SLC29A1,SLC9A3,STAT4,TNFSF10,TNK2,UTRN,YWHAE,YY1 miR-448-3p (and other miRNAs w/seed UGCAUAU) mature microRNA 1.554 3.51E-02 ADD1,APPBP2,ATP2A2,AUTS2,BTBD7,DDX6,JOSD1,MARCH9,MFHAS1,PXMP4,RAPGEF2,SYT9,TPCN1,TTC37,TTYH3,UTRN miR-4472 (and other miRNAs w/seed GUGGGGG) mature microRNA 1.660 2.92E-02 ADD1,AGPAT1,COLQ,EPHX1,GPR173,GRB7,MEF2D,SETD5,STIM1,TTYH3,USP20,ZBTB33 miR-3918 (miRNAs w/seed CAGGGCC) mature microRNA 1.762 1.93E-01 AGPAT1,APOBR,ATP2A2,GPR173,PXMP4,RAB5B,SPDEF,USP20,WDR81 miR-1233-3p (miRNAs w/seed GAGCCCU) mature microRNA 1.798 7.81E-03 ADD1,CCDC137,CXCR5,NTRK2,PXMP4,STIM1,TRIM41 miR-762 (and other miRNAs w/seed GGGCUGG) mature microRNA 1.806 1.00E00 BABAM1,BAZ1B,ERCC2,GPR173,MEN1,MPRIP,NDUFA11,TRABD,TTYH3 valproic acid chemical drug 1.820 4.14E-03 AGPAT1,COLQ,CXADR,CYP2C18,LEPREL1,MEF2D,OSBPL8,SSTR2,TBL1X,TNFSF10,YY1 miR-339-5p (and other miRNAs w/seed CCCUGUC) mature microRNA 1.851 4.72E-02 CCR7,CELF1,JOSD1,MTMR3,NTRK2,PHC1,TMEM79,TNRC6C,WDR81 miR-760-3p (and other miRNAs w/seed GGCUCUG) mature microRNA 1.871 6.77E-02 CYP2C18,KHNYN,LEPREL1,NSD1,NTRK2,UBN1,WDR81 miR-3594-5p (and other miRNAs w/seed CCAGGGC) mature microRNA 1.940 4.77E-03 C9orf69,FGD3,KHNYN,MTMR3,RAB5B,RHOBTB2,SIN3B,SLC25A26,STIM1,SYT9,TNK2,TRABD,TTYH3,USP20,WDR81,ZDHHC5 miR-4695-5p (and other miRNAs w/seed AGGAGGC) mature microRNA 1.964 3.87E-01 CHD9,CTDP1,RAB5B,TEX261 miR-183-5p (miRNAs w/seed AUGGCAC) mature microRNA 1.970 2.33E-01 AUTS2,BAZ1B,CELF1,GPR173,LPPR2,MED13,NTRK2,OSBPL8 IL15 cytokine 1.974 1.60E-02 CCL3,CD5,CD53,LEF1,MST1,PA2G4,PDIA4,PSMB8,S100A11,TNFSF10 miR-3661 (and other miRNAs w/seed GACCUGG) mature microRNA 1.980 1.88E-01 APPBP2,TMEM232,TPCN1,TRIM32 dopamine chemical - endogenous mammalian 1.987 4.46E-02 BAX,CNR1,FST,SSTR2 miR-4487 (miRNAs w/seed GAGCUGG) mature microRNA Activated 2.000 2.30E-01 CDK10,GSTM3,KHNYN,RAB5B miR-320b (and other miRNAs w/seed AAAGCUG) mature microRNA Activated 2.024 5.73E-03 ASH2L,AUTS2,CCR7,CDK13,DHDDS,DIP2C,PCSK6,PHC1,PLK3,PLXNC1,RPL15,S1PR1,SDHC,SMG7,TBL1X,TNRC6C,TRIM32,TRIM41,WNK1,ZBTB33 transcription regulator Activated 2.115 2.01E-01 ADD1,AHCY,BAX,FECH,HLA-A,HSPB1,JARID2,LDHB,NGFRAP1,PSMB8,RPS12,SLC38A1,VDAC2,YY1 miR-150-5p (and other miRNAs w/seed CUCCCAA) mature microRNA Activated 2.190 4.71E-01 ACO1,GRB7,MBD6,NTRK2,STIM1 FOXO3 transcription regulator Activated 2.194 3.84E-02 ALDH3A1,GABARAPL1,MXI1,PIK3CA,TNFSF10 miR-1260a (and other miRNAs w/seed UCCCACC) mature microRNA Activated 2.200 4.11E-01 ACO1,ATF6B,AUTS2,POLA2,WNK1 miR-4640-5p (and other miRNAs w/seed GGGCCAG) mature microRNA Activated 2.200 1.00E00 APPBP2,SMG7,TEX261,TTYH3,WDR6 miR-939-5p (miRNAs w/seed GGGGAGC) mature microRNA Activated 2.200 7.81E-02 CDK10,CELF1,FHL3,KHNYN,MEF2D,NTRK2,PCSK6,SIN3B,SPDEF,STIM1,TTYH3 CXCL12 cytokine Activated 2.219 5.15E-02 BAX,CELF1,CYP2C18,RPS6KB1,TNFSF10 miR-22-3p (miRNAs w/seed AGCUGCC) mature microRNA Activated 2.402 3.01E-02 CDK13,CHD9,CNOT1,EPC1,ERCC2,JARID2,KHNYN,NFAT5,NSD1,NTRK2,PHC1,PHF13,RAB5B,TTYH3 miR-3175 (miRNAs w/seed GGGGAGA) mature microRNA Activated 2.408 1.98E-02 AGPAT1,ASH2L,FHL3,FPGS,KHNYN,MEF2D,MOB3A,PA2G4,PCSK6,RAB5B,SART3,SETD5,TEX261 miR-4283 (miRNAs w/seed GGGGCUC) mature microRNA Activated 2.424 4.26E-04 C9orf69,CD5,CLYBL,ERLIN2,GPR173,GSTM3,MOB3A,NSD1,PER3,PLK3,SIN3B,SMG7,TEX261,TRIM11,UNC93A,USP20 miR-1207-5p (and other miRNAs w/seed GGCAGGG) mature microRNA Activated 2.628 2.39E-01 ASH2L,BCDIN3D,CXCR5,GOLGB1,LPPR2,MAP2K5,PHF13,PLEKHG2,RAPGEF2,STIM1,TNK2,TRABD,WDR81 miR-202-3p (and other miRNAs w/seed GAGGUAU) mature microRNA Activated 3.130 1.00E00 APPBP2,ATP2A2,CCR7,CHD9,DST,KHNYN,MARCH9,TEX261,USP20,UTRN salinosporamide A chemical drug 1.84E-04 BAX,PEBP1,YY1 6-mercaptopurine chemical - endogenous mammalian 1.72E-03 CCR7,TNFSF10 FSTL3 other 1.72E-03 ACVR1,FST GSK3A kinase 2.55E-03 BAX,TNFSF10 SOD1 enzyme 2.69E-03 ACO1,ATF1,BAX,DCXR,GSTM3,HSPB1,PSMB8,STAT4 SHC1 kinase 2.97E-03 BAX,CCR7,S1PR1 PTPN6 phosphatase 3.38E-03 BAX,CCR7,CD5 SLC5A8 transporter 3.54E-03 BAX,TNFSF10 phosphatidylcholine chemical - endogenous mammalian 4.68E-03 BAX,MAT1A delta-9-tetrahydrocannabinol chemical drug 4.68E-03 CNR1,MAP2K2,NTRK2,TNFSF10 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate chemical - endogenous non-mammalian 5.97E-03 CCR7,TNFSF10 desmopressin biologic drug 7.04E-03 GOLGB1,LDHB,NFAT5,S100A11,SLC9A3 HOXA9 transcription regulator 7.57E-03 ARL3,CCL3,CELF1,DHX8,MED13,OSBPL8,PTPRCAP FAS transmembrane 8.74E-03 APPBP2,ARHGEF1,BAX,CCL3,FES,MAP2K5,OPTN,PIK3CA,TNFSF10,TNK2,WNK1 TRPC1 ion channel 8.96E-03 BAX,SNCA 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine chemical toxicant 1.04E-02 BAX,CNR1,FUBP1,HSPB1 rituximab biologic drug 1.07E-02 BAX,PEBP1 polycyclic aromatic hydrocarbons chemical toxicant 1.07E-02 ALDH3A1,BAX SNCA 1.231 other 1.28E-02 BAX,MEF2D,SNCA,YWHAE miR-3678-5p (miRNAs w/seed CCGUACA) mature microRNA 1.30E-02 CXADR,TPCN1,UBAP2L Aspp group 1.33E-02 BAX TLR2/3/4 group 1.33E-02 STAT4 CELSR3 G- coupled receptor 1.33E-02 Nrg1 VTRNA2-1 other 1.33E-02 BAX STAT-1/2 group 1.33E-02 TNFSF10 AP1M1 transporter 1.33E-02 HLA-A PFDN5 transcription regulator 1.33E-02 BAX MAP1B other 1.33E-02 MAP1A GSTT1 enzyme 1.33E-02 GSTM3 RGS5 other 1.33E-02 BAX GPRASP1 transporter 1.33E-02 CNR1 IFI30 enzyme 1.33E-02 HLA-A ETF1 translation regulator 1.33E-02 UTRN JMY transcription regulator 1.33E-02 BAX pomalidomide chemical drug 1.33E-02 CCL3 nabumetone chemical drug 1.33E-02 UTRN 4-cyano-3-methylisoquinoline chemical - kinase inhibitor 1.33E-02 MOS N-(2-guanidinoethyl)-5-isoquinolinesulfonamide chemical - kinase inhibitor 1.33E-02 ALDH3A1 arachidic acid chemical - endogenous non-mammalian 1.33E-02 SNCA YWHAG other 1.44E-02 BAX,UTRN RFX1 transcription regulator 1.44E-02 ALMS1,MAP1A pyruvic acid chemical - endogenous mammalian 1.44E-02 BAX,TNFSF10 RFX3 transcription regulator 1.65E-02 ALMS1,MAP1A dinoprost chemical - endogenous mammalian 1.70E-02 ATP2A2,PDIA4,YWHAE,YY1 methylselenic acid chemical reagent 1.87E-02 CDK10,ENPP5,EPHX1,MAP2K5,MEN1,NREP,PDIA4,ZNF274 DCN other 1.94E-02 BAX,FST,S1PR1 entinostat chemical drug 2.06E-02 BAX,CSF2RA,TNFSF10 miR-4427 (miRNAs w/seed CUGAAUA) mature microRNA 2.10E-02 COBLL1,HEG1 1-methyl-4-phenylpyridinium chemical toxicant 2.10E-02 BAX,SNCA amphetamine chemical drug 2.20E-02 ATF1,BAX,SNCA,STAT4 miR-4788 (miRNAs w/seed UACGGAC) mature microRNA 2.34E-02 CYFIP1,GSTM3 miR-3607-5p (miRNAs w/seed CAUGUGA) mature microRNA 2.45E-02 ADNP,ATP2A2,BTBD7 miR-1245b-3p (miRNAs w/seed CAGAUGA) mature microRNA 2.45E-02 C2orf43,CXADR,SLC38A1 sodium arsenite chemical drug 2.59E-02 AHCY,BAX,TNFSF10 PDPK1 kinase 2.60E-02 CCR7,S1PR1 stearic acid chemical - endogenous mammalian 2.60E-02 BAX,SNCA minoxidil chemical drug 2.64E-02 LEF1 Mellitin chemical - endogenous non-mammalian 2.64E-02 BAX VX-944 chemical drug 2.64E-02 BAX atiprimod chemical drug 2.64E-02 BAX Atg5 other 2.64E-02 BAX MAGEA2/MAGEA2B other 2.64E-02 BAX SP6 transcription regulator 2.64E-02 LEF1 bucillamine chemical drug 2.64E-02 BAX ZMAT3 other 2.64E-02 BAX mir-197 microRNA 2.64E-02 ACVR1 SALL2 transcription regulator 2.64E-02 BAX KCND2 ion channel 2.64E-02 BAX GDF3 growth factor 2.64E-02 PCSK6 PLIN3 other 2.64E-02 BAX SLC2A5 transporter 2.64E-02 SLC9A3 Gm15466 other 2.64E-02 BAX CANX other 2.64E-02 BAX LGALS2 other 2.64E-02 BAX PRIMA1 other 2.64E-02 BAX GDF11 growth factor 2.64E-02 FST reactive nitrogen species chemical - other 2.64E-02 BAX XK469 chemical drug 2.64E-02 BAX AN-207 chemical toxicant 2.64E-02 BAX glyoxal chemical toxicant 2.64E-02 BAX SSR180575 chemical drug 2.64E-02 BAX sodium arsenate chemical toxicant 2.64E-02 PRDX1 M40403 chemical drug 2.64E-02 BAX swainsonine chemical - endogenous non-mammalian 2.64E-02 BAX E64 chemical - endogenous non-mammalian 2.64E-02 TNFSF10 miR-676-3p (miRNAs w/seed UGUCCUA) mature microRNA 2.74E-02 CRIM1,SH3GLB1,SYT9 miR-151-5p (and other miRNAs w/seed CGAGGAG) mature microRNA 2.88E-02 CYB5B,DNMBP,NTRK2 IRF5 transcription regulator 2.88E-02 BAX,CCL3,TNFSF10 3-nitropropionic acid chemical toxicant 3.03E-02 BAX,CNR1,LDHB levothyroxine chemical - endogenous mammalian 3.03E-02 ATP2A2,CYP2C18,PCSK6 IL7R transmembrane receptor 3.13E-02 CCR7,CD5 MAT1A 1.056 enzyme 3.13E-02 BAX,MAT1A RAG2 enzyme 3.13E-02 BAX,CD5 miR-550b-3p (miRNAs w/seed CUUACUC) mature microRNA 3.13E-02 MXI1,TMEM232 CD5 -1.288 transmembrane receptor 3.19E-02 CCL3,CCR7,MAP2K2 Calcineurin A group 3.42E-02 ATP2A2,UTRN SEMA7A transmembrane receptor 3.42E-02 BAX,IL4R transcription regulator 3.42E-02 BAX,PA2G4 BGN other 3.42E-02 BAX,UTRN L-dopa chemical - endogenous mammalian 3.42E-02 BAX,CNR1 miR-933 (miRNAs w/seed GUGCGCA) mature microRNA 3.51E-02 CYB5B,DGKA,PLEKHM2 alefacept biologic drug 3.68E-02 AUTS2,MAP2K2,STAT4 miR-2276 (miRNAs w/seed CUGCAAG) mature microRNA 3.68E-02 APPBP2,CDK13,DST miR-1256 (miRNAs w/seed GGCAUUG) mature microRNA 3.68E-02 CNR1,GABARAPL1,SLC25A26 PARK2 enzyme 3.71E-02 FUBP1,PRDX1 miR-668 (and other miRNAs w/seed GUCACUC) mature microRNA 3.85E-02 MARCH9,MTMR3,PER3 thioguanine chemical drug 3.94E-02 TNFSF10 L-tyrosine chemical - endogenous mammalian 3.94E-02 BAX FFAR3 G-protein coupled receptor 3.94E-02 BAX W146 chemical reagent 3.94E-02 S1PR1 ZNF346 other 3.94E-02 BAX PDLIM2 other 3.94E-02 STAT4 TTC5 other 3.94E-02 BAX CMYA5 other 3.94E-02 ATP2A2 BIRC6 enzyme 3.94E-02 BAX MYBPC3 other 3.94E-02 ATP2A2 MFN2 enzyme 3.94E-02 BAX Ap1 gamma group 3.94E-02 HLA-A RNF144B enzyme 3.94E-02 BAX Betacatenin/TCF complex 3.94E-02 LEF1 SIT1 other 3.94E-02 CD5 PPP1R13B phosphatase 3.94E-02 BAX TIAL1 transcription regulator 3.94E-02 TIA1 CCNL2 other 3.94E-02 BAX IGL@ other 3.94E-02 IL4R AP2A2 transporter 3.94E-02 BAX SDCBP enzyme 3.94E-02 PEBP1 CDON other 3.94E-02 STIM1 UIMC1 other 3.94E-02 BAX phenylacetic acid chemical - endogenous mammalian 3.94E-02 HLA-A hydrochlorothiazide chemical drug 3.94E-02 SLC9A3 2,2'-dipyridyl chemical toxicant 3.94E-02 NTRK2 phosphorothioate oligodeoxynucleotide chemical - other 3.94E-02 CCL3 miR-450a-5p (miRNAs w/seed UUUGCGA) mature microRNA 4.01E-02 ARSK,TNRC6C TNFRSF8 transmembrane receptor 4.02E-02 CCL3,CCR7,TNFSF10 miR-4793-5p (miRNAs w/seed CAUCCUG) mature microRNA 4.02E-02 APPBP2,BCDIN3D,TNFSF10 MAP2K3 kinase 4.02E-02 ATP2A2,BAX,RAB34 miR-1253 (miRNAs w/seed GAGAAGA) mature microRNA 4.33E-02 MED13,RPS6KB1 TSC1 other 4.33E-02 BAX,RPS6KB1 IRF2 transcription regulator 4.39E-02 DST,PSMB8,TNFSF10 HIC1 transcription regulator 4.39E-02 FST,MAP2K5,WDR6 MTOR kinase 4.47E-02 CCR7,RBM5,S1PR1,TNFRSF6B,TNFSF10 PAX3 transcription regulator 4.47E-02 CNR1,FUBP1,MAP2K5,SNCA,TIA1,YWHAE phenylbutazone chemical drug 4.57E-02 GSTM3,PSMB8,S100A11 miR-4677-5p (miRNAs w/seed UGUUCUU) mature microRNA 4.65E-02 BTBD7,SH3GLB1 miR-325-5p (and other miRNAs w/seed CUAGUAG) mature microRNA 4.65E-02 C2orf43,CELF1 PTPRC phosphatase 4.65E-02 CD5,PTPRCAP miR-4795-5p (miRNAs w/seed GAAGUGG) mature microRNA 4.76E-02 BAZ1B,COBLL1,SLC25A26 miR-133a-5p (and other miRNAs w/seed CUGGUAA) mature microRNA 4.76E-02 C2orf43,CHD9,COBLL1 maneb chemical toxicant 4.76E-02 BAX,MARCH9,NFAT5 phenylephrine chemical drug 4.76E-02 ATP2A2,FST,Nrg1 AGTR2 G-protein coupled receptor 4.97E-02 BAX,RPS6KB1 miR-518e-3p (miRNAs w/seed AAGCGCU) mature microRNA 4.97E-02 AUTS2,CLPTM1L PRKD1 kinase 4.97E-02 CD5,MEF2D