Product Datasheet PGC1 Alpha Antibody Orb13647 Biorbyt Ltd

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Product Datasheet PGC1 Alpha Antibody Orb13647 Biorbyt Ltd

Biorbyt Ltd. Biorbyt LLC. 5 Orwell Furlong, Cowley Road, Cambridge 1100 Corporate Square Drive, Helix Center, Suite 221 CB4 0WY, United Kingdom St Louis, MO 63132, United States Email: [email protected] Email: [email protected] Phone: +44 (0)1223 859 353 | Fax: +44 (0)1223 280 240 Phone: +1 (415) 906 5211 | Fax: +1 (415) 651 8558 Product Datasheet PGC1 alpha antibody orb13647 Biorbyt Ltd. Biorbyt LLC. 5 Orwell Furlong, Cowley Road, Cambridge 1100 Corporate Square Drive, Helix Center, Suite 221 CB4 0WY, United Kingdom St Louis, MO 63132, United States Email: [email protected] Email: [email protected] Phone: +44 (0)1223 859 353 | Fax: +44 (0)1223 280 240 Phone: +1 (415) 906 5211 | Fax: +1 (415) 651 8558 Description PGC1 alpha also known as PPARGC1A (PPARG Coactivator 1 Alpha) it is a Protein Coding gene. Diseases associated with PPARGC1A include Obesity and Lipomatosis. Among its related pathways are Signaling mediated by p38-alpha and p38-beta and Circadian rythm related genes. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PPRC1. Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on Western blot analysis of rat the uncoupling protein promoter. Can regulate key mitochondrial heart (lane 1), mouse genes that contribute to the program of adaptive thermogenesis. skeletal Plays an essential role in metabolic reprogramming in response to muscle (lane 2), rat testis dietary availability through coordination of the expression of a (lane 3), mouse colon wide array of genes involved in glucose and fatty acid (lane metabolism. Induces the expression of PERM1 in the skeletal 4), rat thymus (lane 5), muscle in an ESRRA-dependent manner. Also involved in the mouse integration of the circadian rhythms and energy metabolism. liver (lane 6) tissue using Required for oscillatory expression of clock genes, such as anti-PGC1 alpha antibody ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and (0.5 RORC, and metabolic genes, such as PDK4 and PEPCK. ug/ml) Species/Host Rabbit Reactivity Human, Mouse, Rat Conjugation Unconjugated Custom conjugations Unconjugated, HRP Tested Applications WB Immunogen KLH conjugated synthetic peptide derived from human PGC1 alpha. Please contact us for the exact immunogen sequence. The peptide is available as orb374773. Target PGC1 alpha Form/Appearance 10 mM PBS, 0.02% sodium azide Concentration - 100 μg (in 200 μl): 0.5 mg/ml - 200 μg (in 400 μl): 0.5 mg/ml Storage Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles. Note For research use only. Isotype IgG Clonality Polyclonal Purity Polyclonal antibodies are purified by peptide affinity chromatography MW 91 kDa Uniprot ID Q9UBK2 (Human); O70343 (Mouse); Q9QYK2 (Rat) NCBI NP_037393.11; NM_013261.31 Entrez 10891 Dilution Range WB: 1:200-1000 Expiration Date 12 months from date of receipt..

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Location Analysis of Estrogen Receptor Target Promoters Reveals That
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