WIIS Quarterly Report October to December 2007 (United Kingdom)

Total Page:16

File Type:pdf, Size:1020Kb

WIIS Quarterly Report October to December 2007 (United Kingdom) WIIS Quarterly Report October to December 2007 (United Kingdom) Species or Incident sample No. Pesticide Category involved Month County Comments A dog was being walked by its owner, and found and ate some sachets of rodenticide. The owner took her dog to a vet and it recovered. Two dead rats were discovered near to where the dog had found the sachets of rodenticides. Tests confirmed brodifacoum in the liver of both rats and in the stomach contents of one, and in the bait sample. This is likely to be the cause of death. This dog, crow, 2 rodenticide approval ‘for indoor use only’, was found outside in uncovered baits. rats, pesticide An enforcement notice (ensuring carcases removal and cleanup of baits) was 1 brodifacoum misuse sachets December Lincolnshire issued and had been complied with. This case is still under investigation. A dog died after eating an uncovered rodenticide bait in an open Dutch-style barn. Tests on the dog vomit and blue grain were positive for bromadiolone. The farmer was advised about safe pesticide storage and the laying of covered baits which he complied with. A warning letter has been sent. The case is still under 2 bromadiolone misuse dog December Cornwall investigation. A Jack Russell dog was stopped from eating a blue coloured lump of material from a bait box. This had been placed inside a main stables block by a private company. These were not clearly labelled and there were no warning signs of a 3 bromadiolone misuse dog November Wiltshire treatment. Tests confirmed bromadiolone. This case is closed. A dead male fox tested positive for bromadiolone. Though jaundice was also noted, it seems likely given the amount of haemorrhaging the rodenticide was the 4 bromadiolone misuse fox December Surrey cause of its death. This case is closed. Blue-stained whole wheat bait and dead rats were seen along a roadside. The next day the bait had been cleared up, but there were still dead rats on the roadside and evidence of blue staining on one of their tracks near a farm. Tests on the rats confirmed bromadiolone in the livers. An advisory letter was sent to the 5 bromadiolone misuse rat, bait November UARTER farmer. This case is closed. Poisoning was suspected when a pet dog became ill after eating unprotected blue- coloured grain from along a fence line. There were no samples available from the dog to test, though the grain contained difenacoum and a small residue of bromadiolone, bromadiolone. This mixture may have been the result of cross-contamination. 6 difenacoum misuse dog November Northamptonshire PSD has sent an advisory letter to the pest control company. This case is closed. A dog became unwell and was later put down after a rodenticide treatment by a dog, local authority had taken place in its owner’s garden. Tests detected residues of rodenticide difenacoum in grain removed from an open sachet (used in the treatment) and in 7 difenacoum misuse formulation October Essex a sample of faeces. The case is still under investigation. WIIS Quarter 4 Report 2007 Page 1 of 5 WIIS Quarterly Report October to December 2007 (United Kingdom) Species or Incident sample No. Pesticide Category involved Month County Comments A dog became ill after consuming something it found under a plastic bag in a field. Samples from the faeces and slug trap tested positive for metaldehyde. The farmer admitted using slug traps but it cannot be confirmed whether this was done after a recent change to the label for all metaldehyde products that stipulates that dog, pellet slug traps were not to be used. An advisory letter was sent to the farmer and the 8 metaldehyde misuse sample October East Yorkshire case is now closed. Two dead badgers were found near and in the entrance to a badger sett. On inspection a field to the south of the sett was found to have two spillages of slug pellets. The post-mortem revealed a blue paste-like substance in their stomachs and intestines. Tests detected a residue of metaldehyde and this was likely to be metaldehyde, the cause of death. Further tests detected bromadiolone in the livers of both bromadiolone, badgers and a residue of difenacoum in one badger's liver. This was also a 9 difenacoum misuse 2 badgers November Essex contributing factor in their deaths. The case is closed. Buzzard found dead against a fence. A gross residue of alphachloralose was 10 alphachloralose abuse buzzard December Highland confirmed in the gullet content material from the bird. It was suspected that this sample contained a pesticide. Laboratory analysis for some likely pesticides has been undertaken on the submitted sample. These tests have detected a residue of bromadiolone. It appears that grain treated with blue-grain rodenticide, has been left in a garden and this is considered an abuse of the 11 bromadiolone abuse sample October Glamorgan product. A dead buzzard was submitted to the laboratory as a suspected poisoning case. On post-mortem examination the buzzard was found to be in very good condition. There was little evidence of trauma. Carbofuran was found in high levels in the 12 carbofuran abuse buzzard December Londonderry gizzard contents of the buzzard and was thought to be the cause of death. Buzzard seen alive near a partly eaten rabbit carcase, the bird died soon after. Blue granular material was evident on the exposed muscle tissue on the rabbit. The analytical investigation revealed residues of the carbofuran in liver tissue and stomach content material from the bird. A gross residue of carbofuran was also buzzard, detected on the tissue sample analysed from the rabbit. This incident happened in 13 carbofuran abuse rabbit bait December Highland the same area as incidents 14 and 13 of quarter 2 2007 report. A residue of carbofuran was identified and confirmed on the blade of a knife. The knife had been recovered during a police investigation following several red kite 14 carbofuran abuse knife November Tayside poisoning incidents in the area. WIIS Quarter 4 Report 2007 Page 2 of 5 WIIS Quarterly Report October to December 2007 (United Kingdom) Species or Incident sample No. Pesticide Category involved Month County Comments This radio-tagged bird was found dead in a tree. The post-mortem findings indicated that carbamate insecticide poisoning was the likely cause of death. The analytical investigation has confirmed residues of carbofuran in liver tissue and gullet content material from the kite. The source of the chemical is unknown. A Dumfries & low, sub-lethal residue of bromadiolone was also detected in liver tissue from the 15 carbofuran abuse red kite December Galloway bird. This is the third red kite from the same general area that has been poisoned with carbofuran, carbofuran and isofenphos (see incident 14 of quarter 2 2007 report and incident 16 isofenphos abuse red kite October Tayside 13 of quarter 3 2007 report). Two dead ravens were found within four days of each other and a dead buzzard was found nearby. Tests confirmed carbofuran in the gizzards of all the birds and this was likely to be the cause of their deaths. There were background residues of carbofuran, difenacoum and brodifacoum found in the liver of one raven. Brodifacoum was brodifacoum, 2 ravens, found in the liver of the buzzard. The source of the pesticides is not known so the 17 difenacoum abuse buzzard November Shropshire case is closed. An ill pheasant was found on a pheasant shoot on an estate. The post-mortem revealed blue green stained material in the gizzard and intestines. Tests detected difenacoum in the liver and the crop. The amount is significant and is likely to be 18 difenacoum abuse pheasant November Gwynedd the cause of death of this pheasant. dog, A dog was seen to take something from a bowl in a neighbour’s garden. Tests of rodenticide the material in the bowl and from the rodenticide container detected difenacoum. 19 difenacoum abuse formulation November Suffolk The police issued a warning letter to the neighbour. This case has been closed. Two dogs were taken ill in separate incidents after a walk in the same area. The first dog was seen to eat part of a rabbit carcase. Within hours he died. The second dog also died after coming into contact with rabbit remains. Tests confirmed endrin a banned insecticide, in the stomach contents of both dogs, in the rabbit remains and in the stomach contents and liver of a buzzard found recently, in the same area. Further tests revealed a small amount of difenacoum in its liver, though the endrin was the most likely cause of its death. An 2 dogs, enforcement notice has been served on the suspect. The case is still under 20 endrin, difenacoum abuse buzzard November Essex investigation. WIIS Quarter 4 Report 2007 Page 3 of 5 WIIS Quarterly Report October to December 2007 (United Kingdom) Species or Incident sample No. Pesticide Category involved Month County Comments A member of the public reported finding two dead crows in her garden. Earlier in the year she had found dead seagulls and crows on the hill opposite her house. On this occasion a police search of the hill opposite her house found a dead starling and a large quantity of white bread which had been adulterated with a blue chemical. Metaldehyde was identified on the bread but no residue of 21 metaldehyde abuse bread bait November Strathclyde metaldehyde was identified in samples from the starling. A dog fell ill and died after a walk. Later its owner retraced the walk and noted dog, vomit baits near the entrance to a badger sett.
Recommended publications
  • “Baits and Baiting Strategies for Multi-Species Pest Control and Feral
    Baits and baiting strategies for multi-species pest control and feral cats SCIENCE FOR CONSERVATION: 40 D.R. Morgan, J. Innes, C. Ryan, L. Meikle Published by Department of Conservation P.O. Box 10-420 Wellington, New Zealand 1 Science for Conservation presents the results of investigations contracted to science providers outside the Department of Conservation. Reports are subject to peer review within the Department and, in some instances, to a review from outside both the Department and the science providers. November 1996, Department of Conservation ISSN 1173-2946 ISBN 0-478-01855-X This publication originated from work done under Department of Conservation contract 1748 carried out by D.R. Morgan, J. Innes and C. Ryan, Manaaki Whenua – Landcare Research, P.O. Box 69, Lincoln; and contract 617, carried out by D.R. Morgan and L. Meikle, Manaaki Whenua – Landcare Research, P.O. box 31-011, Christchurch. It was approved for publication by the Director, Science and Research Division, Department of Conservation, Wellington. Cataloguing-in-Publication data Baits and baiting strategies for multi-species pest control and feral cats / D.R. Morgan ... {et al.} Wellington, N.Z. : Dept. of Conservation, 1996. 1 v. ; 30 cm. (Science for conservation, 1173-2946 ; 40.) Includes bibliographical references. ISBN 047801855X 1. Pests- -Control- -New Zealand. I. Morgan, D.R. (David Rowland), 1950- II. Series: Science for conservation (Wellington, N.Z.) ; 40. 632.9510993 20 zbn96-124202 2 CONTENTS PART 1: DEVELOPMENT OF MULTI-SPECIES BAITING (D.R. Morgan, J. Innes, C. Ryan) Abstract 5 1. Introduction 5 2. Background 6 3. Objectives 6 4.
    [Show full text]
  • The Persistence and Secondary Poisoning Risks of Sodium Monofluoroacetate (1080), Brodifacoum, and Cholecalciferol in Possums
    THE PERSISTENCE AND SECONDARY POISONING RISKS OF SODIUM MONOFLUOROACETATE (1080), BRODIFACOUM, AND CHOLECALCIFEROL IN POSSUMS C. T. EASON, G. R. WRIGHT, and L. MEIKLE, Manaaki Whenua - Landcare Research, P.O. Box 69, Lincoln, New Zealand. P. ELDER, Steroid and Immunobiochemistry Unit, Christchurch Health Laboratories, Christchurch Hospital, P.O. Box 151, Christchurch, New Zealand. ABSTRACT: To determine the risk of secondary poisoning for animals preying on sub-lethally poisoned brushtail possums, captive possums were treated with near-lethal doses of sodium monofluoroacetate (1080) or brodifacoum, and toxicant concentrations in blood and tissue were monitored over time. Sodium monofluoroacetate was rapidly eliminated from the blood (within three days). Brodifacoum was retained in the liver and, to a lesser extent, the muscle of possums for eight months after dosing. To determine the potential risk for animals scavenging on the carcasses of possums poisoned with cholecalciferol, cats were fed poisoned carcasses for six days. No changes in behavior, appetite, or body weight were observed. Serum calcium concentrations increased slightly, but remained within the normal range for cats. KEY WORDS: vertebrate pest control, secondary poisoning, sodium monofluoroacetate, brodifacown, cholecalciferol Proc. 17th Yertebr. Pest Conf. (R.M. Timm & A.C. Crabb, Eds.) Published at Univ. of Calif., Davis. 1996. INTRODUCTION 1995), and toxic amounts of brodifacoum may be retained Sodium monofluoroacetate (1080) has been used for in a carcass. vertebrate pest control in New Zealand since 1954. It is The existence of an effective antidote to brodifacoum currently used most frequently in aerially sown baits and in the form of vitamin Kl means that dogs that have eaten in baits in bait stations for the control of the Australian carcasses containing brodifacoum residues can usually be brushtail possum (Trichosurus vulpecula) (Livingstone saved.
    [Show full text]
  • Pharmacokinetics of Anticoagulant Rodenticides in Target and Non-Target Organisms Katherine Horak U.S
    University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln USDA National Wildlife Research Center - Staff U.S. Department of Agriculture: Animal and Plant Publications Health Inspection Service 2018 Pharmacokinetics of Anticoagulant Rodenticides in Target and Non-target Organisms Katherine Horak U.S. Department of Agriculture, [email protected] Penny M. Fisher Landcare Research Brian M. Hopkins Landcare Research Follow this and additional works at: https://digitalcommons.unl.edu/icwdm_usdanwrc Part of the Life Sciences Commons Horak, Katherine; Fisher, Penny M.; and Hopkins, Brian M., "Pharmacokinetics of Anticoagulant Rodenticides in Target and Non- target Organisms" (2018). USDA National Wildlife Research Center - Staff Publications. 2091. https://digitalcommons.unl.edu/icwdm_usdanwrc/2091 This Article is brought to you for free and open access by the U.S. Department of Agriculture: Animal and Plant Health Inspection Service at DigitalCommons@University of Nebraska - Lincoln. It has been accepted for inclusion in USDA National Wildlife Research Center - Staff ubP lications by an authorized administrator of DigitalCommons@University of Nebraska - Lincoln. Chapter 4 Pharmacokinetics of Anticoagulant Rodenticides in Target and Non-target Organisms Katherine E. Horak, Penny M. Fisher, and Brian Hopkins 1 Introduction The concentration of a compound at the site of action is a determinant of its toxicity. This principle is affected by a variety of factors including the chemical properties of the compound (pKa, lipophilicity, molecular size), receptor binding affinity, route of exposure, and physiological properties of the organism. Many compounds have to undergo chemical changes, biotransformation, into more toxic or less toxic forms. Because of all of these variables, predicting toxic effects and performing risk assess- ments of compounds based solely on dose are less accurate than those that include data on absorption, distribution, metabolism (biotransformation), and excretion of the compound.
    [Show full text]
  • Authorisation of Anticoagulant Rodenticides in Germany FAQ on Environmental Risks, Risk Mitigation Measures and Best Practice
    background // december 2019 Authorisation of Anticoagulant Rodenticides in Germany FAQ on Environmental Risks, Risk Mitigation Measures and Best Practice For our environment Imprint Publisher: Image sources: German Environment Agency Front page: Fotolia/tomatito26 Section IV 1.2 Biocides Page 3: UBA/Agnes Kalle & Susanne Hein Section IV 1.4 Health Pests and their Control Page 7: Alex Yeung PO Box 14 06 Page 8: Taton Moïse/Unsplash 06813 Dessau-Roßlau Page 10: autark – Photocase Tel.: +49 340-2103-0 Page 11: UBA/Figure 1 [email protected] Page 12: Fotolia/silvioheidler/Figure A Internet: www.umweltbundesamt.de/en Page 12: Fotolia/Jolanta Mayerberg/Figure B Page 12: Fotolia/Erni/Figure C /umweltbundesamt.de Page 12: Fotolia/Hans and Crista Ede/Figure D /umweltbundesamt Page 12: Fotolia/Sergey Ryzhkov/Figure E /umweltbundesamt Page 12: Fotolia/phototrip.cz/Figure F /umweltbundesamt Page 14: Fotolia/Loveleen/Silhouette of a rat Page 17: Photocase/marsj/Mouse in building Authors: Page 17: UBA/Erik Schmolz/Bait station Juliane Fischer, Anton Friesen, Anke Geduhn, Susanne Page 17: Fotolia/SB/Rat burrow in open area Hein, Stefanie Jacob, Barbara Jahn, Agnes Kalle, Anja Page 18: Mella/Photocase Kehrer, Ingrid Nöh, Eleonora Petersohn, Caroline Page 20: Fotolia/fotocejen/Barn owl Riedhammer, Ricarda Rissel, Annika Schlötelburg, Erik Page 21: Fotolia/Stefan/Kestrel Schmolz, Beatrice Schwarz-Schulz, Christiane Stahr, Ute Page 21: Fotolia/Romuald/Stoat Trauer-Kizilelma, Kristina Wege, Stefanie Wieck Page 22: Fotolia/Valeriy Kirsanov/Red fox Page
    [Show full text]
  • Sound Management of Pesticides and Diagnosis and Treatment Of
    * Revision of the“IPCS - Multilevel Course on the Safe Use of Pesticides and on the Diagnosis and Treatment of Presticide Poisoning, 1994” © World Health Organization 2006 All rights reserved. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either expressed or implied. The responsibility for the interpretation and use of the material lies with the reader. In no event shall the World Health Organization be liable for damages arising from its use. CONTENTS Preface Acknowledgement Part I. Overview 1. Introduction 1.1 Background 1.2 Objectives 2. Overview of the resource tool 2.1 Moduledescription 2.2 Training levels 2.3 Visual aids 2.4 Informationsources 3. Using the resource tool 3.1 Introduction 3.2 Training trainers 3.2.1 Organizational aspects 3.2.2 Coordinator’s preparation 3.2.3 Selection of participants 3.2.4 Before training trainers 3.2.5 Specimen module 3.3 Trainers 3.3.1 Trainer preparation 3.3.2 Selection of participants 3.3.3 Organizational aspects 3.3.4 Before a course 4.
    [Show full text]
  • The Evaluation of Alternative Toxins to Sodium Monofluoroacetate (1080) for Possum Control
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by UNL | Libraries University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln Proceedings of the Fifteenth Vertebrate Pest Vertebrate Pest Conference Proceedings Conference 1992 collection March 1992 THE EVALUATION OF ALTERNATIVE TOXINS TO SODIUM MONOFLUOROACETATE (1080) FOR POSSUM CONTROL Charles T. Eason Forest Research Institute, P.O. Box 31-011, Christchurch, New Zealand Follow this and additional works at: https://digitalcommons.unl.edu/vpc15 Part of the Environmental Health and Protection Commons Eason, Charles T., "THE EVALUATION OF ALTERNATIVE TOXINS TO SODIUM MONOFLUOROACETATE (1080) FOR POSSUM CONTROL" (1992). Proceedings of the Fifteenth Vertebrate Pest Conference 1992. 24. https://digitalcommons.unl.edu/vpc15/24 This Article is brought to you for free and open access by the Vertebrate Pest Conference Proceedings collection at DigitalCommons@University of Nebraska - Lincoln. It has been accepted for inclusion in Proceedings of the Fifteenth Vertebrate Pest Conference 1992 by an authorized administrator of DigitalCommons@University of Nebraska - Lincoln. THE EVALUATION OF ALTERNATIVE TOXINS TO SODIUM MONOFLUOROACETATE (1080) FOR POSSUM CONTROL CHARLES T. EASON, Forest Research Institute, P.O. Box 31-011, Christchurch, New Zealand ABSTRACT: Possum control in New Zealand is dependent on the use of sodium monofluroacetate (1080) and cyanide. Although 1080 is highly effective, its use is restricted to government staff. Cyanide is available for a wider group of licensed operators, but cyanide "shyness" reduces its effectiveness. An acute toxicity programme has been set up to identify non- anticoagulant toxins that could be used safely by farmers. Dose-ranging studies showed that possums are susceptible to cholecalciferol, calciferol, gliftor, alpha-chloralose, and nicotine, but not to bromethalin.
    [Show full text]
  • RRAC Guidelines on Anticoagulant Rodenticide Resistance Management Editor: Rodenticide Resistance Action Committee (RRAC) of Croplife International Aim
    RRAC guidelines on Anticoagulant Rodenticide Resistance Management Editor: Rodenticide Resistance Action Committee (RRAC) of CropLife International Aim This document provides guidance to advisors, national authorities, professionals, practitioners and others on the nature of anticoagulant resistance in rodents, the identification of anticoagulant resistance, strategies for rodenticide application that will avoid the development of resistance and the management of resistance where it occurs. The Rodenticide Resistance Action Committee (RRAC) is a working group within the framework of CropLife International. Participating companies include: Bayer CropScience, BASF, LiphaTech S. A., PelGar, Rentokil Initial, Syngenta and Zapi. Senior technical specialists, with specific expertise in rodenticides, represent their companies on this committee. The RRAC is grateful to the following co-authors: Stefan Endepols, Alan Buckle, Charlie Eason, Hans-Joachim Pelz, Adrian Meyer, Philippe Berny, Kristof Baert and Colin Prescott. Photos provided by Stefan Endepols. Contents 1. Introduction ............................................................................................................................................................................................................. 2 2. Classification and history of rodenticide compounds ..............................................................................................3 3. Mode of action of anticoagulant rodenticides, resistance mechanisms, and resistance mutations ......................................................................................................6
    [Show full text]
  • Final Soft Bait Singapore Date Created: March 2017 Supplier: Bell Laboratories, Inc
    FINAL®SOFT BAIT SAFETY DATA SHEET ACCORDING TO REGULATION: Section 274 of DATE OF ISSUE: PREPARED BY: the Work Health and Safety Act March 2017 CAR SECTION 1. PRODUCT AND COMPANY IDENTIFICATION Product Identifier: FINAL® SOFT BAIT Relevant identified uses: Anticoagulant Rodenticide - Ready to use Uses advised against: Use only for the purpose described above MANUFACTURER: IMPORTER: EMERGENCY PHONE NUMBERS: Bell Laboratories, Inc. Bentz Jaz Singapore Pte Ltd Consult the local/regional poison control 3699 Kinsman Blvd. 48 Toh Guan Road East, center. Madison, WI 53704, USA Enterprise Hub #06-139 email: [email protected] Singapore 608586 t +65 6841 2986 I f +65 6841 2026 www.bentzjaz.com.sg SECTION 2. HAZARDS IDENTIFICATION THIS PRODUCT IS CLASSIFIED AS: NOT HAZARDOUS ACCORDING TO THE CRITERIA OF SWA. NOT A DANGEROUS GOOD ACCORDING TO AUSTRALIAN DANGEROUS GOODS (ADG) CODE, IATA OR IMDG/IMSBC CRITERIA. SUSMP Classification: S6 ADG Classification: None allocated. Not a Dangerous Good according to Australian Dangerous Goods (ADG) Code, IATA or IMDG/IMSBC criteria. UN Number: None allocated GHS Signal word: WARNING HAZARD STATEMENT: H373: May cause damage to organs through prolonged or repeated exposure. PREVENTION P102: Keep out of reach of children. P264: Wash contacted areas thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P273: Avoid release to the environment. RESPONSE P313: Get medical attention/advice P321: Treatment with Vitamin K, which is antidotal, is almost always successful P337: If eye irritation persists: seek medical attention P353: Rinse skin or shower with water. P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
    [Show full text]
  • Acting Anticoagulant Rodenticides (Laars) That Inhibit the Action of Vitamin K1
    0++- Poison HOTLINE 1-800-222-1222 October 2014 Rodenticides Anticoagulants have historically been a common chemical used in rodenticides in the U.S. Initially, warfarin was the active ingredient. As rodents became resistant to warfarin, it was replaced with second generation anticoagulants, labeled “super warfarins,” and include brodifacoum, bromodialone, chlorphacinone, difenacoum, diphacinone, or pindone. The “super warfarins” are long-acting anticoagulant rodenticides (LAARs) that inhibit the action of vitamin K1. Synthesis of clotting factors II, VII, IX, X, protein Did you know …… C and protein S require vitamin K as a cofactor. Without vitamin K, the clotting factors cannot be activated and coagulopathy results. Bromethalin is increasingly being used in rodenticide Prolongation of the prothrombin time (PT) or INR is usually the first indication products. Bromethalin is a that a coagulopathy exists. Prolonged INR may be evident within 24 hours, but cellular poison, NOT an usually reaches a maximum 36-72 hours after an LAAR ingestion. A normal anticoagulant. INR 48 hours after exposure rules out significant ingestion. Large acute ingestions can Small accidental ingestions are common – particularly seen when toddlers produce signs of toxicity as ingest a few LAAR pellets. The majority of these cases do not result in a early as 2-4 hours post- prolonged INR or significant bleeding. Large ingestions can cause nosebleeds, ingestion, but toxicity is more bleeding gums, hematuria, melena and extensive bruising. Note: typically seen 8-12 hours post- anticoagulation symptoms are delayed until existing Vitamin K stores are ingestion. Symptoms may be depleted, and thus symptoms begin several days after ingestion.
    [Show full text]
  • Acute Rodenticides: in Canada, Only Two Chemical Compounds, Which Are Acute Toxins, Are Registered for Use As Rodenticides: Strychnine and Zinc Phosphide
    Rodent Management on Farms and in New Tree Planting to Prevent Accidental Poisonings of Raptors and Other Non-Target Wildlife Bernie Solymar Coordinator, Ontario Barn Owl Recovery Project Revised September 2001 This paper discusses the biology of common rodent species found in farm and natural environments in Ontario, commonly used rodenticides on Ontario farms, nurseries and in new tree plantings, potential for non-target poisoning by rodenticides, and methods to reduce and/or eliminate risk of accidental poisonings to non-target organisms. Biology and Descriptions of Common Rodents Considered Pests Rodents are always associated with farm environments. Farm structures provide shelter and sources of food, especially corn cribs, hay lofts and grain stores. Orchards provide grassed habitat and tree bark an alternative source of food in winter. Ginseng gardens and strawberry fields are favored due to straw mulch used in these crops and voles and mice are not adverse to nipping on ginseng buds and roots and strawberry crowns. Headlands, ditch banks, hedgerows and meadows and hay fields are all favorable rodent habitat. The following table describes common rodents found in farm structures and in and around agricultural farmed land: Farm Structures Farm Structures Orchards, Tree (i.e. barns, silos, kilns, etc.) and Orchards Plantings Common name Norway Rat House Mouse Deer Mouse Meadow Vole & (Field Mouse) White-footed Mouse Scientific name Rattus norvegicus Mus musculus Peromyscus Microtus manicuatus pennsylvanicus & P. leucopus Number of
    [Show full text]
  • Successful Reversal of Anticoagulant Effect of Brodifacoum Poisoning with 4-Factor Prothrombin Complex Concentrate (PCC4)
    Open Access Austin Journal of Pharmacology and Therapeutics Case Report Successful Reversal of Anticoagulant Effect of Brodifacoum Poisoning with 4-Factor Prothrombin Complex Concentrate (PCC4) Kusmierski KA*, Lackie CL and Scull JR Department of Pharmacy, Millard Fillmore Suburban Abstract Hospital, USA Title: Successful reversal of anticoagulant effect of brodifacoum poisoning *Corresponding author: Kusmierski KA, Department with 4-factor prothrombin complex concentrate (PCC4). of Pharmacy, Millard Fillmore Suburban Hospital, USA Introduction: Brodifacoum is a long-acting anticoagulant rodenticide that Received: March 17, 2017; Accepted: April 05, 2017; is similar to warfarin, but significantly more potent with prolonged half-life and Published: April 11, 2017 potential for severe coagulopathy. Case: A 43-year-old woman presented to the emergency department with non-traumatic bruising, abdominal pain, and hematuria. Initial evaluation revealed a severe coagulopathy and international normalized ratio (INR) greater than 13. PCC4 (Kcentra®) 25units/kg, phytonadione, and fresh frozen plasma (FFP) were administered with improvement in INR without additional intervention to control bleeding. A rebound increase in INR occurred within 24 hours. Brodifacoum toxicity was confirmed (brodifacoum level=300ng/mL) after patient admitted to possible cutaneous and aerosolized exposure to “rat poison.” The patient required FFP and high doses of phytonadione to control coagulopathy throughout her admission. She was discharged on phytonadione. Discussion: PCC4 administration improved coagulation parameters rapidly with control of bleeding and no adverse effects. The rebound in coagulation parameters demonstrated the continued need for treatment of coagulopathy while awaiting confirmation of brodifacoum poisoning. Conclusion: This case illustrates successful acute reversal of brodifacoum poisoning with Kcentra®, phytonadione, and FFP.
    [Show full text]
  • Brodifacoum Coagulopathy from Tainted Synthetic Cannabinoids
    SMGr up Case Report SM Journal of Brodifacoum Coagulopathy from Clinical Medicine Tainted Synthetic Cannabinoids James Granfortuna* Department of Hematology and Oncology, Cone Health teaching affiliate UNC Chapel Hill Medical Center, USA Article Information Abstract Received date: Nov 03, 2018 A recent cluster of patients presenting with idiopathic, severe, coagulopathy was reported in Illinois and Accepted date: Nov 16, 2018 traced to contaminated cannabinoids. The contaminating substance was determined to be brodifacoum, a potent, long acting, rodenticide that inhibits vitamin K dependent clotting factor production. Since the original reports from Published date: Nov 19, 2018 the Midwest, multiple additional cases have been reported in at least 11 states. Brodifacoum toxicity has now reached the proportions of a public health crisis. Patients can present with bruising, epistaxis, oropharyngeal and *Corresponding author gum bleeding, excessive menstrual bleeding, hematemesis, hematuria, flank pain, or abdominal pain mimicking an acute abdomen. We present a case of brodifacoum toxicity that was rapidly reversed with parenteral Vitamin James Granfortuna, Department of K and K-centra, four factor clotting concentrate. The use of intermittent prothrombin complex concentrates has Hematology and Oncology, Cone the ability to control life threatening hemorrhage and is a potential important adjunctive treatment to minimize Health teaching affiliate UNC Chapel use of large doses of vitamin K. Hill Medical Center, 1200 N Elm St, Greensboro, NC 27401, USA, Case Report Tel: 336-312-4050; Email: james. Case history [email protected] Distributed under Creative Commons A 54 year old male in good health except for treated hypertension and remote history of CC-BY 4.0 nephrolithiasis.
    [Show full text]