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APRIL 03 Nucleus DED UN 18 O 98 F yyyy N yyyy Y O T R E I T H C E N O yyyy A E S S S L T A E A C R C I yyyyN S M S E E H C C T N IO A April 2003 Vol. LXXXI, No. 8 yyyyC N • AMERI Monthly Meeting Esselen Award to Bruce D. Roth: “The Discovery and Development of Lipitor® (Atorvastatin Calcium)” Felice Frankel’s Imagery Technology Enables New Scientific Images to Emerge ACS Short Course LC/MS Fundmentals and Applications, May 19-20, 2003 Interstellar Chemistry From a Faraday Lecture by William Klemperer Chair-Elect: J. Fuller-Stanley men- Standing Committees: Board of tioned the locales of the upcoming Bd. Of Publications: P. Gordon monthly meetings. She is negotiating reported that a professor from Tufts is with future meeting sites to obtain interested in becoming the new web- Directors favorable prices and she is also master. The Board is waiting for a pos- Notes of Meeting of January 9, addressing means to decrease program itive arrangement. J. Neumeyer asked expenses: purchase of an LCD projec- whether we should have the website 2003 tor to save on rental cost. operated by a professional. P. Gordon NOTE: Board Meetings are held on the Treasurer: J. Piper presented the responded that he thought there is monthly meeting day at 4:30 p.m. December 2002 financial report. He plenty of capability within the Section Section members are invited to attend. stated that there may be a temporary to maintain a website. A decision is to cash shortage until allocations from the be reached shortly. Officers’ Reports: trustees and the national ACS have Editor: The February issue will be Chair: J. Neumeyer thanked the sev- been received. 20 pages. Advertising is ahead of eral members of the Board, staff for Trustees: The Section’s investments budget. their efforts. He also thanked NESACS are performing well. Membership: M. Chen stated that one past chair, M. Hoffman for his able Archivist: M. Simon asked past chairs new member is expected for the dinner leadership and presented him with the who may have bound volumes of The at this meeting. ACS Past Chairman pin. He also wel- Nucleus to donate them to the archives. Budget: J. Piper distributed the draft comed J. Fuller-Stanley as incoming There was some discussion whether 2003 budget. Initial requests exceeded Chair-Elect. J. Neumeyer outlined past issues should be digitized and expected income by $50,000. The some of the plans for the current year: stored on CDs. A. Heyn countered that budget committee reduced this to a fundraising by the Medicinal Chem- with the rapid change of technologies, $15,000 deficit. The budget will be istry Group, improving the website. He CD’s may no longer be decipherable voted at the February Board meeting. also urged committees to stay within when software and hardware changes. Nominating: M. Hoffman asked those the Section’s budget. G. Weisman responded that, as new who wish to have one of the elected In order to help reduce meeting technologies become standard, previ- positions to let their willingness to costs to the Section, dinner prices will ous formats can be converted to remain stand for election be known soon. The be raised starting with March. usable. slate will be presented at the February continued on page 6 Join Us- Waters International GPC 2003 and ISPAC-16 Symposium June 7-12, 2003 Baltimore Marriott Waterfront Hotel Baltimore, MD For information and registration visit: www.waters.com/GPC2003 Sponsored by Waters Corporation and the International Symposium on Polymer Analysis and Characterization (ISPAC) 2 The Nucleus April 2003 The Northeastern Section of the American Chemical Society, Inc. Contents Office: Marilou Cashman, 23 Cottage St., Natick, MA 01760. 1-800-872-2054 (Voice or FAX) or 508-653-6329. Board of Directors _____________________________________2 e-mail: [email protected] Any Section business may be conducted Notes of the meeting of January 9, 2003 via the business office above. NESACS Homepage: http://www.NESACS.org Gustavus J. Esselen_____________________________________4 Frank R. Gorga, Webmaster A brief biography of this illustrious past member and Section Chair Washington, D.C. ACS Hotline: 1-800-227-5558 Officers 2003 Monthly Meeting _______________________________________5 Chair: Esselen Award to Bruce D. Roth for the synthesis and development of Lipitor® John L. Neumeyer Harvard Medical School/McLean Hospital 115 Mill St., Belmont, MA 02478 Nominations Invited – Henry A. Hill Award __________________5 617-855-3388; [email protected] Chair-Elect: Book Review __________________________________________6 Jean A. Fuller-Stanley Chemistry Department, Wellesley College “Hydrogen. The Essential Element” by J.S. Rigden, reviewed by L.J. Zompa Wellesley, MA 02481-8203 781-283-3224; [email protected] Felice Frankel’s Imagery _________________________________7 Immediate Past Chair: Morton Z, Hoffman Reprint of the Nieman Report:“Technology Enables New Scientific Images to Chemistry Department, Boston University Emerge” by our March 2003 speaker Boston, MA 02215-2507 617-353-2494; [email protected] Secretary: ACS Short Course ______________________________________9 Michael Singer LC/MS:Fundamentals and Applications; May 19-20 at Northeastern University Sigma RBI 3 Strathmore Rd. Natick, MA 01760-2447 Interstellar Chemistry _________________________________10 508-651-8151x291 From a Faraday Lecture at the Royal Institution, London, by William Klemperer [email protected] Treasurer: James Piper Cover: Dr. Bruce D. Roth, the 2003 Gustavus J. Esselen Awardee 19 Mill Rd., Harvard, MA 01451 978-456-3155 [email protected] Deadlines: Summer Issue: June 13, 2003 Auditor: September Issue: July 19, 2003 Anthony Rosner Archivist: Myron Simon 20 Somerset Rd. Newton, MA 02465; 617-332-5273 [email protected] Trustees: Joseph A. Lima, Esther A.H. Hopkins, Michael E. Strem, Councilors: Alternate Councilors: Term Ends 12/31/2003 Term Ends 12 /31/2003 The Nucleus is distributed to the members of the Northeastern Section of the American Chemical Catherine E. Costello Wallace Gleekman Society, to the secretaries of the Local Sections, and to editors of all local A.C.S. Section publications. William Klemperer Arno H.A. Heyn Forms close for advertising on the 1st of the month of the preceding issue. Text must be received by the Dorothy J. Phillips Howard R. Mayne editor six weeks before the date of issue. Barbara Wood Alfred Viola Editor: Arno Heyn, 21 Alexander Rd., Newton, MA 02461, Term Ends 12/31/2004 Term Ends 12/31/2004 Tel: 617-969-5712, FAX: 617-527-2032; e-mail: [email protected] Thomas R. Gilbert Timothy B. Frigo Patricia H. Hamm Donald O. Rickter Associate Editors: Myron S. Simon, 20 Somerset Rd., W. Newton, MA 02465, Tel: 617-332-5273 Michael J. Hearn Lawrence T. Scott Mukund S. Chorghade, 14 Carlson Circle, Natick, MA 01760: Arlene W. Light Derk A. Wierda [email protected] Term Ends 12/31/2005 Term Ends 12/31/2005 Board of Publications: Marietta H. Schwartz (Chair), Patrick M. Gordon, vacant, E. Joseph Billo (Con- Mary T. Burgess Michaeline F. Chen sultant) Morton Z. Hoffman Patrick M. Gordon Business Manager: Karen Piper, 19 Mill Rd., Harvard, MA 01451, Tel: 978-456-8622 Doris I. Lewis Truman S. Light Amy E. Tapper Michael Singer Advertising Manager: Vincent J. Gale, P.O. Box 1150, Marshfield, MA 02050, Tel: 781-837-0424; FAX: 781-837-8792 All Chairs of standing Contributing Editors: Patricia Hamm, Features; Edward Atkinson, History of Chemistry; Dennis Committees, the editor Sardella, Book Reviews; Marietta H. Schwartz, Software Reviews. of THE NUCLEUS, and Calendar Coordinator: Donald O. Rickter, e-mail: [email protected] the Trustees of Section Proofreaders: E. Joseph Billo, Mukund S. Chorghade, Donald O. Rickter, M.S. Simon Funds are members of the Webpage: Webmaster: Samuel P. Kounaves, [email protected] Board of Directors. Any Asst. Webmasters: Terry Brush, [email protected] Councilor of the American Chemical Society Kurt Heinselman, [email protected] residing within the section area is an ex officio member of the Board of Directors. Copyright 2003, Northeastern Section of the American Chemical Society, Inc. The Nucleus April 2003 3 Gustavus Biography Corporate Patrons Astra Zeneca Pharmaceuticals John Dr. Roth was born in Philadelphia, PA Novartis Pharmaceutical Corp. He received a bachelors degree in Strem Chemicals, Inc. Chemistry from St. Joseph’s College in Esselen, Philadelphia, PA. During his under- Corporate Sponsors graduate career, he performed research Aerodyne Research, Inc. 1888-1952 under the direction of Dr. George L. Cambridge Isotope Laboratories Nelson. He then moved to Iowa State Consulting Resources Corp. An extensive biography was published University where he received a Ph.D. Houghton Chemical Corp. in the April 2000 issue of The in synthetic organic chemistry in 1984 New England Biolabs, Inc. NUCLEUS. under the direction of Dr. George A. Organix, Inc. Kraus, working on the total synthesis Gustavus John Esselen was one of the Polymedica Corp. of antifungal antibiotics, including the Sigma-RBI movers and shakers in the Northeast- total synthesis of the antifungal, antibi- ern Section, serving on numerous com- otic (±)-Kalafungin. Dr. Roth had mittees, Chairman twice (1922, 1923) postdoctoral training under the direc- and also a Director of the national tion of Dr. Andrew S. Kende at the ACS. He chaired the national meetings University of Rochester in Rochester, Red Sox of the ACS held in Boston in 1928 and N.Y. (1981 – 1982) during which he 1939. He was employed by General completed the total synthesis of the Tickets Electric Co. in Lynn, then Arthur D. insect antifeedant (±)-Ajugarin IV and Little, Inc. of Cambridge. In 1921 he the anticancer agent (±)-Quadrone. April 17, 2003 at 6:05 pm founded Gustavus J. Esselen, Inc., In 1982 Dr. Roth joined the Ather- Red Sox vs.
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