ANNUAL REPORT

2005

Northeastern Section American Chemical Society

Local Section Name: Northeastern Section URL for Total Report: http://www.nesacs.org

Dr. Amy Tapper

Chair 2005 Northeastern Section, ACS

2 TABLE OF CONTENTS (Pages numbered separately by section) Pages PART I - QUESTIONNAIRE

Annual Report Questionnaire ......

PART II: ANNUAL NARRATIVE REPORT

Activities: First Annual Golf tournament ...... Chair's Networking and Social Events...... Connections to ...... National Chemistry Week Activities...... German Exchange Program...... YCC Career Symposium and Career Fair...... NSCRC 2005...... Virtual Meeting ...... Bike Event...... Summary...... 2005 Goal Attainment 2005 Local Section Goals and Assessment ...... 2005 Chair's Goals and Assessment...... 2006 Goals...... Suggestions / Concerns...... ACS Strategic Thrusts......

PART II - APPENDICES 1-5

APPENDIX 1 - SUPPORTING DOCUMENTS FOR ACTIVITIES

Supporting Documents for Activities First Annual Golf tournament ...... Chair's Networking and Social Events...... Connections to Chemistry ...... National Chemistry Week Activities...... German Exchange Program...... YCC Career Symposium and Career Fair...... NSCRC 2005...... Virtual Meeting ...... Bike Event......

APPENDIX 2 - BUDGETS AND LONG-RANGE PLAN

Report of the Treasurer ...... 2-A: Budget for 2005 ...... Budget for 2006 ...... 2-B: Long-Range Plan......

APPENDIX 3 - MEMBERSHIP SURVEYS AND 2005 NEWSLETTER

3-A: Membership Survey Conducted in 2005 ...... 3-B: 2005 Newsletter...... April, 2005 issue of The Nucleus uploaded to ACS online report (S.O.L.A.R.)

3

APPENDIX 4 - PUBLIC RELATIONS PLAN - TALKS TO PUBLIC - NEWSPAPER CLIPPINGS

4-A: Public Relations Plan ...... 4-B: Talks to Public...... 4-C: Press Releases ......

APPENDIX 5 - AS NEEDED BY SECTION: NESACS REPORTS

Officers, Councilors, Directors, and Committee Chairs 2005 ...... Calendar of Activities 2005...... Reports: Archivist...... Awards Committee...... Awards Presented by the Northeastern Section ...... Brauner, Phyllis A. - Memorial Lecture...... Continuing Education Committee ...... Corporate Funding...... Education Committee ...... Education Committee / High School Subcommittee ...... Esselen Award Committee...... Government Relations Committee...... Local Arrangements Committee...... Medicinal Chemistry Group ...... Membership Committee ...... National Chemistry Week Committee...... NERM 2005 ...... Nominating Committee...... Norris Award Committee...... Professional Relations Committee ...... Program Committee / Chair-Elect...... Publications, Board of...... Richards Medal Committee...... Speakers' Bureau ...... Summerthing 2005 ...... Treasurer ...... Trustees, Board of ......

APPENDIX 5-A: Programs and Publications

Northeast Student Research Conference...... Connections to Chemistry...... Undergraduate Research Symposium at Bridgewater State College......

APPENDIX 6 - YOUNGER COMMITTEE

Report of the Younger Chemists Committee ......

4 PART III - ANNUAL FINANCIAL REPORT

Part A: Statement of Revenues and Expenses Operating Fund ...... Part B: Balance Sheet as of 12/31/05......

PART IV - SELF-NOMINATIONS FOR CHEMLUMINARY AWARDS

Outstanding Performance by Local Sections ......

Outstanding Local Section Younger Chemists Committee...... Outstanding or Creative Local Section Younger Chemists Committee Event......

Outstanding On-going NCW Event ...... Outstanding Event for the General Public Using the Yearly Theme Award...... Best Student Affiliate Event......

5

Annual Report Northeastern Section

PART I

ANNUAL REPORT QUESTIONNAIRE

http://www.nesacs.org American Chemical Society

6

Form: Part I - Annual Report Questionnaire REQUIRED Organization: Northeastern Year: 2005

****Important Notice Please Read****

The EZ form consists of the Part I - Questionnaire, Part III - Financial Report and the Optional Part IV - Self-Nomination Form for ChemLuminary Awards. Sections that wish to submit the EZ form are not required to submit the Part II - Narrative and Appendices. All local sections are eligible to complete the EZ form UNLESS, they would like to self-nominate themselves for the LSAC Award for Outstanding Performance by a Local Section. Local sections may submit the EZ form and self-nominate themselves for any of the other awards listed in Part IV. Local Sections must postmark or submit their completed annual reports electronically by February 15, 2006 to be eligible for any of the awards

We do not wish to be considered for the Local Section Outstanding Performance Award

*Part I Annual Report Questionnaire *Part II Annual Report Narrative and Appendices (Optional) *Part III Financial Report *Part IV Self Nomination for ChemLuminary Awards (Not Eligible for Local Section Outstanding Performance Award (Optional)

Our section would like to be considered for the ACS Local Section Outstanding Performance Award. We are submitting Parts I,II,III and IV of the annual report

*Part I Annual Report Questionnaire * Part II Annual Report Narrative& Appendices * Part III Financial Report * Part IV Self Nomination for ChemLuminary Awards (***Outstanding Performance Award Nomination must be completed***)

Web Posting of Annual Reports

Our Section would like to have Parts I and II (if applicable) posted on the Local Section Activities Committee website.

1. Top Activities

Please list the titles of your top activities (in rank order) and indicate if the activity was new in 2005. Check if new in 2005 Title of Activity

Golf Tournament 1. Chair's Newtworking and Social Events 2. Connections to Chemistry 3. National Chemistry Week Activities 4. Younger Chemists Committee Career Fair 5.

7 German Exchange Program 6. Northeast Student Chemistry Research Con 7. Virtual Meetings 8. Bike Event 9. Summerthing 10.

2. Section Administration

EXECUTIVE COMMITTEE

8 2.1 How many times did the executive committee meet during 2005?

68 2.2 How many members are on the executive committee?

7 2.3 How many section meetings were held in 2005?

87 2.4 On average, how many members attend regular section meetings? COUNCILORS

100 2.5 What percentage of the section's Councilors were in official attendance at the ACS spring Council meeting? %

93 2.6 What percentage of the section’s Councilors were in official attendance at the ACS fall Council meeting? % 2.7 How do Councilors report to the section about national ACS matters? (check all that apply)

at a section meeting at an executive committee meeting

in the newsletter on the local section website COMMITTEES 2.8 Specify active committees having two or more members.

Awards Newsletters/Publications

Budgets/Finance Nominations

Career/Employment Assistance Professional Relations

Chemistry Olympiad Project SEED

Continuing Education Public Relations

Education Senior Chemists

Environmental Environmental Health and Safety/ Chemical Hygiene

Government Affairs Women Chemists

Industry Relations Younger Chemists

Other Local Arrangements Long-Range Planning Other Constitution and Bylaws Membership/Member Retention

8 Other Brauner Memorial Lecture Mentoring Other Corporate Funding Minority Affairs

National Chemistry Week SUBSECTIONS

0 2.9 How many subsections are active in the section?

0 2.10 How many subsection meetings were held in 2005? TOPICAL GROUPS

1 2.11 How many topical groups are active in the section?

3 2.12 How many topical group meetings were held in 2005? OPERATIONS AND PLANNING (Check all that apply)

2.13 The section prepared a budget for 2005 (Please include a copy in Part II Appendix 2)

2.14 The section prepared a budget for 2006 (Please include a copy in Part II, Appendix 2) 2.15 The section prepared a long-range plan (Please include a copy in Part II, Appendix 2)

2.16 The section maintains and uses a current job manual prepared by the section as a guide for officers and committees. The section conducted a membership survey in 2005 to determine member's interests and needs (Please include a copy in 2.17 Part II, Appendix 3) 2.18 A section representative attended the ACS Leaders Conference (Local Section Leaders Track) in 2005. SECTION COMMUNICATION

10 2.19 How many newsletters were published in 2005? 2.20 One copy of a newsletter is included in Appendix 3.

34 2.21 How many meeting notices were published in 2005? URL: http://www.nesacs.org 2.22 The section has an active website. 2.23 The section used electronic communication. 2.24 The section posted its 2004 Annual Report on its website. SECTION ELECTIONS

504 2.25 How many members voted in the 2005 officer election? 2.26 How many current elected officials, councilors and committee chairs:

6 a. have held other elected positions in the local section

15 b. have held other appointed positions in the local section

10 c. are in their first two years of service

2.27 Did any of the following candidates for election run upopposed for election in 2005? Yes No N/A

9 a. Chair-elect

b. Treasurer c. Secretary d. Councilor e. Other Director-at-Large

SECTION AWARDS (check all that apply) 2.28 The section submitted a nomination for the ACS Regional Award in High School Chemistry Teaching during 2005. The section gave awards or a Salutes to Excellence to:

2.29 Primary school students (K-6)

2.30 Secondary school students (7-12)

2.31 College students

2.32 Primary school teachers (K-6)

2.33 Secondary school teachers (7-12)

2.34 College teachers

2.35 Members of the local section for service

2.36 Outstanding (s), regardless of section affiliation

2.37 The section or local company encouraged and/or submitted a nomination for the ACS Regional Industrial Innovation Awards. SECTION AFFILIATES

19 2.38 How many paid section affiliates excluding students (teachers, technicians, others) are there in the section? 2.39 Section has supported an existing Technician Affiliate Group (TAG)during 2005. 2.40 Section has promoted the formation of a Technician Affiliate Group during 2005 REGIONAL MEETINGS

2.41 Does your local section have a representative to your Regional Board/Steering Committee? 2.42 Does your section participate in the Regional Chmemjobs Employment Center? VOLUNTEERS What is the approximate number of currently active volunteers in your local section (Volunteer is defined as a 99 2.43 member who helps plan or organize a meeting or activity, serves on a committee, or is an elected official.)

Please indicate alll the ways that you recognize your 2.44 volunteers.

Certificates Gifts

Awards Letter to Volunteer

Letter to Vol. Supervisor Recognition at Event

No Formal Recognition program Other than normal succession of chair-elect to chair how does your local section identity future leaders and get them into the 2.45 leadership pipline?

10 Self-Nominations Solicitation or advertising

Identify Active Members Formal leadership training

Outreach to new members Arm-Twisting

Other

3 - 8 ACS Strategic Plan Core Strategies

CORE STRATEGY #1 Provide Timely State-of-the-Art Chemical Information(Check all that apply)

3.1 The section organized a regional meeting.

An ACS Technical Division was involved.

3.2 The Section organized a symposium.

An ACS Technical Division was involved.

3.3 The organized a Meeting-in-Miniature.

An ACS Technical Division was involved.

3.4 The section organized an undergraduate research symposium.

An ACS Technical Division was involved.

3.5 The section organized a meeting that was co-sponsored by an ACS Technical Division. CORE STRATEGY #2 Serve as the Premiere Professional Organization for Practitioners of Chemistry (Check all that apply)

4.1 The section provided services for pre-college students. 4.2 The section provided speakers for student affiliate chapter meetings.

4.3 The section organized tours of local industries for student affiliate chapters.

4.4 The section offered financial support for student affiliate chapter activities. 4.5 The section offered financial support to students attending regional or national meetings undergraduate or graduate 4.6 The section appointed a member as student affiliate chapter liiaison 4.7 The section members served as non faculty professional advisors or contacts for students and young chemists 4.8 The section provided students with free subscriptions to journals. 4.9 The section invited student affiliates to attend regular section meetings. 4.10 The section sponsored a teacher affiliate group to engage students in ACS. 4.11 The section involved student affiliates in National Chemistry Week activities. 4.12 The section distributed career literature to students or to colleges and universities. 4.13 The section developed or maintains a networking directory. CORE STRATEGY #3 Enhance the Public Appreciation of the Chemical Sciences and Technologies (Check all that apply)

5.1 Providing Judges for area science fair(s)

11 5.2 Sponsoring awards at area science fair(s)

5.3 Members make visits to K-12 classrooms. 5.4 Presenting career programs and/or distributing career literature to students or schools 5.5 Sponsoring or organizing student competitions (e.g., chemistry examinations, Chembowls, poster competitions) 5.6 Presenting Chemical Demonstrations 5.7 Participating in US National Chemistry Olympiad The section encourages paticipation and leadership in all aspects of the chemical sciences by women (W) underrepresented groups (G) and persons with disabilities (D) (Check all that apply) W G D

5.8 Section members mentored students or colleagues 5.9 The section sponsored hands-on science activities in underserved communities. 5.10 The section provided summer research opportunities.

5.11 The section developed science career fairs at high schools or colleges that have high female, minority or disabled populations. 5.12 The section organized summer science camps.

5.13 The section sponsored contests or awards. 5.14 The section maintained employment services

5.15 The section leadership (elected or appointed) includes underrepresented groups.

5.15 Local section members interacted with federal government officials (i.e., members of congress, agency staff, etc.) to encourage funding of research Local section members interacted with federal government officals (i.e., members of Congress, agency staff, etc.) to encourage support for ACS workforce 5.16 policy issues.

5.16 The section maintained an experts roster and provided it to local media.

5.17 The section created or updated a media list. 5.18 The section prepared a public relations plan and included a copy of this plan in Appendix 4.

5.19 How many times were section activities promoted to the local media (press releases, op-eds, advisories, etc.)?

5.20 The section used an ACS film, videotape, or other ACS visual-aid resource at a public event.

5.21 How many talks were given by section members to the public in 2005?

5.22 The section conducted a chemical hygeine, responsible care or environmental health and safey event for the general public. 5.23 The section offered its services to the local community as a resource on chemical hygeine, responsible care or environmental health and safety. 5.24 The section carried out environmental activities for the general public. 5.25 The section participated in or conducted the following community activities:

Chemists Celebrate Earth Day Chemists in the Library

Chemagination Contest National Chemistry Week (NCW) 5.26 The section conducted the following activities during NCW 2005:

Hands-on activities Chemical Demonstrations

12 Contests or games Lectures or training

NCW Youth Patch

Other

5.27 The section's NCW Activities were carried out in the following venues:

K-8 schools High Schools Colleges or Universities

Industrial Sites Museum/Libraries Shopping Malls

Other

5.28 The section worked with the following group(s) to produce NCW events:

K-8 schools High Schools Colleges or Universities

Industry Museums or Libraries Scout Troops

Civic Orgnizations

Other

5.29 The section publicized NCW via:

Newspapers/magazines/flyers Radio Television Website

5.30 The section participated in the NCW unifying event in 2005.

What is the total number of year that the NCW coordinator has served in this capacity? 3 5.31 5.32 The section has a Government Relations Representative.

5.33 The section hosted state or federal government officials to speak at a local section meeting. The section organized or participated in a special government relations event(state capitol day, science town meeting, legislative hearing, public policy 5.34 forum, etc.). 5.35 The section informed its members on legislative issues and events through newsletter article, website, or other communications method.

5.36 The section member(s) held an office or key position in state or federal government in 2005.

5.37 The section actively encourages members to join and actively participate in the ACSs Legislative Action Network (LAN).

5.38 The section arranged for visits with federal elected officials when they are home on recess.

CORE STRATEGY #4 Transform the Defination of Chemistry to Encompass Its True Multidisciplinary

6.1 The section has topical groups in interdisciplinary areas. 6.2 The section has sponsored meetings with an interdisciplinary focus. 6.3 The section offered activities such as symposium, seminars, or sponsored student activities on environmental issues. CORE STRATEGY #5 Deliver a Dynamic and Integrated Porfolio of Products and Services. (Check all that apply)

7.1 The section published articles on employment services in its newsletter or website.

13 The section sponsored local employment services (e.g., free ads in section newsletter or website, job counseling, employment clearing 7.2 house)

7.3 A section representative attended a Local Section Career Program during 2005

7.4 The section referred individuals to national ACS Department of Career Services.

7.5 The section maintained a job line for positions available within the local section.

7.6 The section hosted an ACS short course.

7.7 How many local section career programs or activities were conducted in 2005?

7.8 Of the local section programs that were conducted in 2005, how many were new?

7.9 The section offered career counseling/literature.

7.10 The section maintains a list (and contact information of local organizations (networking directory) that employ chemical profe

7.11 Does your section have a career coordinator? CORE STRATEGY #6 Promote Inclusiveness Throughout the Chemical Enterprise (Check all that apply)

8.1 Conducting teacher workshops

8.2 Inviting teachers to attend section meetings.

8.3 Providing teachers with free subsciptions to magazines and journals 8.4 Involving teachers in section program planning 8.5 Participation in Project SEED 8.6 Presenting a forum to address educational issues

8.7 The section offered specifically tailored symposium, seminars, or sponsored activities for industrial chemical professionals. 8.8 Industrial members are active in the section's governance

8.9 The section communicated with non-ACS members working in industry and local companies about meetings and programs. 8.10 Local companies have financially-sponsored and activity or donated money to the section. 8.11 Industrial members (M), local companies (C), and/or non-members employed in industry (N) participated in these section programs or activities. M C N

Meeting at industrial site/plant tour Local Section Award/Recognition program Membership Drive for new members Industrial speaker/Industrially focused topic

NCW or community activities Career Development activities Student or younger chemist activities

The section is affiliated with other technical or scientific societies or 8.12 consortia. 8.12a If the section has a formal affiliation with

14

(Name of organization)

This affiliation was approved by ACS council in what year 8.13 The section held a meeting jointly with another professional organization. ACS STRATEGIC PLAN 2004 - 2006 The American Chemical Society Strategic Plan focuses on the commitments to our Science, our profession and the Public. The plan sets forth a bold course that builds on the traditional strengths of the society and concentrates on emerging needs and opportunities. The plan focuses on six core strategies that the Society will pursue to lead and support the chemical enterprise into the future. For more information on the ACS Strategic Plan, please visit chemistry.org

15

ANNUAL REPORT Northeastern Section, ACS

PART II

ANNUAL NARRATIVE REPORT

http://www.nesacs.org

16 PART II - NARRATIVE

Form: Part II - Annual Narrative Report Optional for EZ Submission Organization: Northeastern Year: 2005

A. Activities Please describe and rank up to ten of your section's activities during 2004. Provide (a) the title of the activity, (b) a one paragraph description of the activity, and (c) an indication of which ACS Strategic Thrusts. Please refer to the end of this section for a listing of the ACS Strategic Thrusts or see Part I, questions 3-12. If you wish to provide details beyond these paragraphs, please do so in Appendix 1.

Activity #1 a) Title: 1st Annual String Scramble Golf Tournament b) Description (Please limit to one paragraph) On Monday, June 6th, forty-seven golfers teed off at Wentworth Hills Country Club in Plainville in the first NESACS String Scramble Golf Tournament. Golfers came from as far away as Wisconsin to participate. Although the day started cool it turned into a beautiful sunny day for golf and the conditions on the course were perfect. Golf was preceded by a buffet luncheon. The Vertex team of Mick Hurrey, David Miller, and Ray Forslund won the spirited competition with an outstanding score of 55 (par 71). Second was claimed by the team of Marc Cadell, Jeff Wilson, Bruce Shutts, and Ed Price and third by the team of Amy Tapper, Panos Kalaritis, Brian Robbins, and Gary McGhee. The men’s long drive competi- tion was won by Mark Cirolo with a drive of 374 yards and the women’s long drive was won by Amy Tapper. The closest to the pin award was won by Brian Robbins. The awards were given at the banquet which followed the tournament. Much fun was had by all. Thanks to generous sponsorships by IRIX (Osmium level); Hovione, Lyophilization Service of New England, DSM, and Cardinal Health (Platinum level); Rhodia Pharma Solutions, Teledyne ISCO (Gold level); and Vertex, Genzyme Drug Discovery and Development, and Peptimmune (Silver level) a total of $8,400 was raised to support NESACS activities. Plans are underway for the second annual golf tournament in June 2006.

c) Which Strategic Thrust(s) does this activity support? (Please refer to the List of Strategic Thrusts) 1 2 3 4 5 6 ( x ) This activity was new in 2005

Activity #2 a) Title: Chair's Networking and Social Events b) Description (Please limit to one paragraph) The main focus of my year as Chair was to engage participation in NESACS through networking/social events. There were four main networking and social events in 2005, which included two brewery tours/dinners, a bike ride, and a golf tournament. The Chair's first social/networking event at the Harpoon Brewery and No Name Restaurant held in January was a great success, despite the record-breaking snowfall. We had a 50% cancellation due to the inclement weather. This event was co-sponsored by the WCC and YCC. Thirty-five attended the brewery tour/lecture and the dinner at the Boston landmark, the No Name Restaurant. The Bike (or Skate, Run or Walk) the Minuteman Bikeway and the golf tournament (which was the major 2005 networking/social event) are discussed in detail in this section. The final Chair’s networking and social event held in November, which was also co-sponsored by the YCC and WCC, was a beer tasting and dinner at the Cambridge Brewing Company. For this event I was able to get Dishman Pharmaceuticals to sponsor the cost of the beer tasting/lecture. There were thirty in attendance. Overall these events were quite successful in getting members who usually don’t attend monthly meeting to participate and form interest in NESACS activities

17 c) Which Strategic Thrust(s) does this activity support? (Please refer to the list of Strategic Thrusts) 1 2 3 4 5 6 ( x ) This activity was new in 2005

Activity #3 a) Title Connections to Chemistry b) Description (Please limit to one paragraph) The sixth Connections to Chemistry program was held at Burlington (MA) High School on Wednesday, October 19th. This program is designed to connect high school chemistry teachers with the numerous education resources that are available from the American Chemical Society. We again had an exceptionally good response to the program and closed the registration at 150 registrants. The 2005 President of the ACS, Dr. William Carroll, was at the opening session to welcome the participants to the program, and to encourage them to utilize the ACS resources and to consider affiliate membership in the Division of Chemical Education via the new Chemistry Teacher Connection (CTC) program. In addition to the welcome, Dr. Carroll also presented one of the workshops for the program--Why Don’t You Just Make All the Plastic Alike? In addition to this workshop, four other workshops were given: Toying with Chemistry, the National Chemistry Week workshop (John Mauch, Chemistry teacher, Belmont High School), It’s a Small, Small World, a workshop (Arthur Watterson, UMass Lowell), Seeing the Unseeable, a technology workshop for enhancing demonstrations (Walter Rohr, Eastchester High School, NY), and Power from the Nucleus, a workshop on nuclear power and radioactive sources, (Gilbert Brown, UMASS Lowell; and David Barr, Seabrook Power Station). c) Which strategic thrust(s) does this activity support? (Please refer to the list of Strategic Thrusts) 1 2 3 4 5 6 ( x ) This activity was new in 2005

Activity #4 a) Title: National Chemistry Week Activities b) Description (Please limit to one paragraph) The National Chemistry Week Kick-Off event was held at Wellesley College on October 16, 2005. More than 40 volunteers from the Brauner Committee, Bridgewater State College, Clark University, Emmanuel College, Simmons College, Suffolk University, Tufts University and Wellesley College ensured the day ran smoothly for the 325+ individuals that attended the daylong event. Dr. Bassam Shakhashiri presented the Phyllis A. Brauner Memorial Lectures. These lecture demonstrations (11 – 12 and from 2 – 3 pm) were filled to capacity. A toy drive was held that day at Wellesley College and all donated toys were passed on to needy children in the Northeastern Section. Visitors throughout the day enjoyed making slime, super balls, nature prints, bunny copters, and marker butterflies as well as learned how to elicit a reversible color change in Barbie’s hair. To increase participation in the kick-off event, a concerted effort was made to increase publicity. For example, the Massachusetts Association of Science Teachers (MAST) posted information regarding the event on their website. Postings also occured in local magazines and newspapers. Organizations such as the Boy Scouts and Girl Scouts were notified as well. c) Which Strategic Thrust(s) does this activity support? (Please refer to the list of strategic thrusts.) 1 2 3 4 5 6 ( ) This activity was new in 2005

Activity #5 a) Title: German Exchange Program b) Description (Please limit to one paragraph)

18 NESACS has continued its tradition of supporting the exchange program between the Northeastern Section and the German Chemical Society. During the week of April 3, 2005 ten graduate and two undergraduate students from colleges and universities in the Boston area (Harvard, MIT, BC, BU, Tufts, Dartmouth College, University of New Hampshire) traveled to Germany to participate in the 5th annual NESACS/GDCh exchange program. The German Chemical Society (GDCH) as well it’s Younger Chemists Committee (JungChemikerForum) organized the week long program which included participation in an a three-day international chemistry conference, visits to Schering, the chemistry departments at the Technical University of Berlin, the University of Potsdam, and a tour of the Max Planck Institute of Colloids and Interfaces. The students also experienced German cultural activities and were able to develop contacts with their scientific peers from all over Germany and the surrounding countries. Plans are being discussed to hold the annual exchange in Boston 2007 to coincide with the ACS National Meeting in Boston.

c) Which Strategic Thrust(s) does this activity support? (Please refer to the list of Strategic Thrusts) 1 2 3 4 5 6 ( ) This activity was new in 2005

Activity #6 a) Title: YCC Career Symposium and Career Fair b) Description (Please limit to one paragraph) 2nd annual NSCCF (Northeast Student Chemistry Career Fair) was held in Brookline at the Holiday Inn on March 31, 2005 was a continuation of highly successful Career Fair held last year. The four-hour program constitutes a set of workshops on resume writing and inter-viewing, resume review as well as the career fair itself. All the parts of the program were held simultaneously. Representatives from 9 regional companies made themselves available for greeting and discussing employment with ~120 attending younger chemists. Companies that attended include Strem Chemicals, Inc., Merck, Novartis Institutes for Biomedical Research, Genzyme, Wyeth, Sigma-RBI, ArQule, Amgen, and the Graduate Women in Science. Many beneficial contacts were made through the Fair. One representative from Wyeth said, "Very successful event, we have collected fewer resumes from bigger career fairs. Looking forward to another job fair next year!" c) Which Strategic Thrust(s) does this Activity Support? (Please refer to the list of Strategic Thrusts. 1 2 3 4 5 6 ( ) This activity was new in 2005

Activity #7 a) Title: NSCRC 2006 b) Description (Please limit to one paragraph) The Seventh Annual Northeast Student Chemistry Research Conference (NSCRC) took place at the Massachusetts Institute of Technology on Saturday, April 23, 2005. The event, located in the Ray and Maria Stata Center, attracted approximately 60 participants from schools in the Boston area. The Ray and Maria Stata Center at MIT provided exceptional facilities for the conference at a lower price than in previous years at Boston University. It also helped to attract new students. The event featured 6 graduate/undergraduate oral presentations and 39 poster presentations. Cash prizes donated by Strem Chemicals, Graduate Women in Science as well as book gift certificates donated by Springer were awarded to the best graduate and undergraduate presentations. NSCRC 2005 was a great success in terms of attracting new students and improving organization. c) Which strategic Thrust(s) does this activity support? (Please refer to the list of Strategic Thrusts). 1 2 3 4 5 6 ( ) This activity was new in 2005

Activity #8 a) Title: Virtual Meeting

19 b) Description (Please limit to one paragraph)

As part of a ACS Local Section Innovative Grant, the September meeting of the NESACS Board of Directors was held via an Internet forum. Members of the Board were sent instructions on how to post reports, how to communicate amongst the members and how to vote. The participants in the Internet forum were able to communicate to one another as described in the instructions. We learned that our older membership wasn't receptive to electronic communications at the present time. Most weren't familiar with the idea of a discussion board and few if any made the effort to learn how to use the discussion board. We provided written instructions and a virtual practice session, but this didn't get many board members activated. It is important to underscore the importance of this experiment and although our current experiment may have failed, NESACS/ACS needs to keep abreast of the technology and to embrace it if they want to attract and retain younger members. We believe our idea might still be viable for sections with distance constraints like Montana. As our current chair recommends, this format could be attempted nationwide and that ACS could offer the disaffected membership the option of participating in a nationwide E-section in which the activities, etc. would obviously be web-based. c) Which strategic Thrust(s) does this activity support? (Please refer to the list of Strategic Thrusts). 1 2 3 4 5 6 ( x ) This activity was new in 2005

Activity #9 a) Title: Bike Event b) Description (Please limit to one paragraph) An even half dozen chemists from NESACS met at the Uncle Sam statue in Arlington on June 1 to bike and walk the Minuteman Bikeway. After being postponed due to a late-season Nor’easter on May 27th, cyclists were pleased to have a very beautiful evening for the ride. Four took a leisurely bike ride up to Lexington, where they enjoyed the evening light. Our section webmaster broke away from the pack, rocketing up the path all the way to the terminus in Bedford, about 9 miles each way. One person took a walking tour of the bike path and the town of Arlington, visiting the library and the town gardens. At dusk the group met at Krazy Karry’s Backyard BBQ for some excellent burgers and a discussion of the connections between biking and chemistry. Tom Hansen Ph.D., CMC Manager at ARIAD Pharmaceuticals told the group about the use of flow cytometry for blood analysis, and how this analytical technique was used to disqualify local cycling hero Tyler Hamilton. The ride leader was Joe Snodgrass Ph.D.,from ARIAD.

.c) Which strategic Thrust(s) does this activity support? (Please refer to the list of Strategic Thrusts). 1 2 3 4 5 6 ( ) This activity was new in 2005

Activity #10 a) Title: Summerthing b) Description (Please limit to one paragraph) An annual tradition of the Northeastern Section continued during the summer of 2005. Summerthing, which is attendance at Red Sox games by NESACS members and their families and friends, was even more popular than ever due to the 2004 Red Sox World Series win! An announcement appeared in March Nucleus for the annual Summerthing Red Sox games (May 21 Red Sox vs. Atlanta, June 5 Red Sox vs. Anaheim, June 28 Red Sox vs. Cleveland, and Sept 17 Red Sox vs. Oakland). Without saying, the tickets were completely sold with many

20 NESACS members wishing that they had been able to get in on the event. Tickets were sold at face value with the addition of a $5 surcharge for Education committee. This event made a profit of $390 for the Section. Plans are underway for Summerthing 2006.

c) Which strategic Thrust(s) does this activity support? (Please refer to the list of Strategic Thrusts). 1 2 3 4 5 6 ( ) This activity was new in 2005

B. Summary - Overall Section Activities

Please summarize in 1,000 words or less, the activities of the section in 2005 which have not been already described. Outstanding events should be described in some detail and appropriate attachments included in Appendix 1. Programs described here may be featured in publications produced by the ACS Membership Division and/or at the Local Section Leadership Conferences.

It was my honor to Chair the Northeastern Section in 2005. It was another successful year for the Section, and even with the top ten activities description above, I find it difficult to describe all of the 2005 NESACS activities in 1,000 words or less. It should be noted that for the majority of our 2005 events, photos and articles were submitted to The Nucleus and photos were also posted on the NESACS and NESACS –YCC websites.

Monthly Meetings The Membership Committee sent letters to the more than a thousand new members of the Section, inviting them to the monthly meetings as the Section’s guest at the dinner that precedes the lecture. Attendance at the meetings of the Board of Directors, which precedes the monthly meetings, had excellent attendance. Additionally, the Social Hours preceding the monthly dinners and talks were lively and provided excellent networking opportunities. For the second year, NESACS co-sponsored a monthly meeting with the Boston Area Group for Informatics and Modeling (BAGIM). The meeting was held at the Harvard Faculty Club and there were 90 people at the meeting, one of the highest attended meetings. Nine monthly meetings of the Executive Committee were held (the February meeting had to be cancelled because of a snow storm) and our September Board meeting was dedicated to Long-Range Planning. This year we also had a formal photographer at our monthly meetings. Our photographer is a student from Northeastern University.

Awards During 2005, the Section sponsored and presented the James Flack Norris Award in Physical Organic Chemistry to Dr. Martin Saunders at the Spring 2005 ACS National Meeting in San Diego, CA. In addition, the Section presented the following awards:. Gustavus J. Esselen Award to Dr. Jean M. J. Fréchet for Chemistry in the Public Interest. The James Flack Norris Award for Outstanding Achievement in the Teaching of Chemistry was also awarded to Dr. Morton Z. Hoffman . The Henry A. Hill Award for Outstanding Service to the Northeastern Section was presented to Dr. Charles E. Kolb at the October meeting.

NESACS/ACS scholars

21 The Section renewed its financial commitment to the ACS Scholars program in 2004 by pledging $2500 each year for the four years (2004-2007) to a worthwhile and necessary program. Additionally, the Section invites all ACS Scholars attending academic institutions within our Section to attend monthly meetings and dinner as guests of the section.

The Nucleus The Section is very proud of both the quality and timeliness of our monthly newsletter, The Nucleus. After the passing of our long-term Editor, Arno Heyn, Dr. Mike Filosa from Polaroid has taken on this huge volunteer commitment. We are grateful to our editor, associate editors, and our board of publications for keeping the publication on time as well as maintaining high standards.

Education Committee NESACS has an extremely active Education Committee, chaired by Dr. Ruth Tanner from UMASS Lowell. Prof. Ed Brush has accepted the invitation to join the Education Committee as the coordinator for the ACS student affiliates in NESACS. He will be building a database of the affiliates, which will be updated yearly. The database will also include the advisors and specific contact persons for each affiliate. Below are some of the highlights of the committee’s activities.

Newell Grants The Lyman C. Newell Grants for the NEACT 67th Annual Summer Conference on Pedagogy and the Standards at Central Connecticut State University, August 1-4, 2005. The Lyman C. Newell Grants commemorate a former chair of the Northeastern Section who was a distinguished chemist, teacher, and historian of chemistry.

Norris/Richards The James Flack Norris and Theodore William Richards Undergraduate Summer Research Scholarships NESACS established the James Flack Norris and Theodore William Richards Undergraduate Summer Scholarships to honor the memories of Professors Norris and Richards by promoting research interactions between undergraduate students and faculty. Research awards of $3250 were given for the summer of 2005.

Brauner Undergraduate Book Award The Brauner Undergraduate Book Award to honor Phyllis Brauner was given at the NSCRC to Maryann Racine, from MIT for her outstanding poster Fluorescent Sensors for Hg(II) in Aqueous Solution and presentation of her work.

Ashdown Exam This year's Avery Ashdown Exam was a success as 98 sat for the exam. This year's group of students represented 27 schools from across the section. Our mission with the Ashdown remains three-fold: 1. To use our local section exam as a qualifier for the USNCO exam; 2. To award students for their chemical knowledge and recognize their efforts (and their teachers) on this challenging exam at the annual Education Night awards evening; 3. To increase participation with the exam and continue to publicize our efforts so that more students and schools will take the exam.

Grants-in-Aid Awarded Grants-in-Aid of $250 each to four undergraduates at colleges and universities within the Northeastern Section to enable them to attend the ACS National Meeting in Atlanta, Georgia to present a paper at the Undergraduate Research Poster Session in the Division of Chemical Education on Monday, March 27, 2006.

22 Student Affiliate Chapter Awards From C&EN: Four student affiliate chapters within NESACS were cited. Among those designated as Commendable are Simmons College (student leaders: Marcy Keddy and Azra Idrizovic; faculty advisor: Richard Gurney) and Suffolk University STUDENT AFFILIATE CHAPTER AWARDS (student leader: Raksmey Im; faculty advisor: Doris Lewis). Bridgewater State College (student leader: Bethany Masten; faculty advisors: Edward Brush and Cielito DeRamos King) and Northeastern University (student leaders: Courtney Hrank and Amy Kallmerten; faculty advisor: Thomas Gilbert) received Honorable Mention.

The Fourteenth Annual ACS Northeast Regional Undergraduate Day Held on November 5, 2005. The keynote address Electrically Releasing Adhesives Using Nanostructured Epoxies was given by Prof. Michael Gilbert of EIC Laboratories. Additional presentations were name by Prof. Nolan Flynn of Wellesley College, Prof. Adam Yeager of Boston University, and Prof. John Porco of Boston University. Among other activities were the Graduate School and Industry Fair, and workshops on choosing a graduate school and on increasing the activities of the student affiliates.

Environmental Research Symposium

On Saturday, November 12, 2005, the 4th Annual Environmental Research Symposium was held in the John Joseph Moakley Center at Bridgewater State College. The Symposium featured 28 poster presentations from 57 student co-presenters. Over 75 students, faculty and mentors were in attendance. Continuing Education The National ACS Short Course Synthetic Organic Chemistry: Modern Methods and Strategies was presented by Professor Paul Helquist, from Notre Dame University, on November 17-18, 2005.

Career Services Committee NESACS has an extremely active Career Services Committee, chaired by Dr. Mukund Chorghade. Committee activities are detailed in the ChemLuminary section.

C. Local Section and Chair Goals

1. 2005 Goal Attainment. The Local Section Activities Committee strongly encourages local section planning. As a result, the 2005 local section annual report should follow-up on the attainment of goals. Please list the goals you set at the beginning of your term for your section and yourself, and report on the attainment of the goals. a) 2005 Local Section Goals and Assessment: 1. Goal: Completely redesign the NESACS website with emphasis on the employment link. Ensure that the website maintains current information. Set up a NESACS mailing list link.

Assessment: In order to completely redesign our website, we paid $1000.00 to a member of our Section, Sathish Rangarajan, who works at the Center for Chemical Methodology and Library Development Boston University. The Northeastern Section website, www.nesacs.org, steadily grew in popularity over the last year with an average daily hit of about 1000. A new streamlined version was formally launched in the last week of March 2005. The new site is 25% leaner and presents an easier interface for navigation. The most visited pages include the ones relating to the Avery Ashdown examination, the local seminar calendar, The Nucleus and the job postings. In

23 the summer of 2005, NESACS established a discussion forum on the section's website (www.nesacs.org/discuss) and tested the viability of conducting monthly meetings over the Internet. There is also a link to sign up for the NESACS mailing list from which fliers about monthly meetings and other section news/events are publicized. The NESACS web team now includes the webmaster, Sathish Rangarajan, Rachel Schindler in charge of the *Local Seminar Calendar* and links therein; Dr.Michele Mandrioli takes care of the *Photo Gallery*. At 195 MB, the current disk consumption is well below the allotted space of 800 MB.

2. Goal: Recruitment of younger chemists, student affiliates, high school teachers, and industrial chemists for attendance at monthly meetings and participation on NESACS committees.

Assessment: Overall, the programs/events that were held in 2005 supported the goal of recruitment of younger chemists, student affiliates, high school teachers, and industrial chemists for attendance at monthly meetings and participation on NESACS committees. As listed in the activities above, the 1st Annual String Scramble Golf Tournament, Chair's Networking and Social Events, Connections to Chemistry, National Chemistry Week Activities, German Exchange Program, YCC Career Symposium and Career Fair, Northeast Student Chemistry Research Conference (NSCRC), Virtual Meeting, bike event, and Summerthing contributed to the increased attendance at monthly meeting and also contributed to the recruitment of new members for our board and its committees.

3. Goal: Promote financial support from industry

Assessment: In 2005 NESACS was very successful in raising funds from industry. As an industrial chemist, I believe that it is important to gain financial support from industry for local sections, especially due to the fact that there are so many pharmaceutical and biotech companies in the northeast region. The primary source of donations came from the golf tournament. I was able to find industrial sponsors to sponsor holes of the golf tournament. Each sponsor had a sign printed with their company name at the hole at which they were sponsoring and the company with the highest amount of sponsorship also had a banner at the banquet. I had different levels of sponsorship and NESACS is thankful for the generous contributions from IRIX (Osmium level); Hovione, Lyophilization Service of New England, DSM, and Cardinal Health (Platinum level); Rhodia Pharma Solutions, Teledyne ISCO (Gold level); and Vertex, Genzyme Drug Discovery and Development, and Peptimmune (Silver level). A total of $8,400 was raised to support NESACS activities. These companies are recognized in patron section in The Nucleus for one year for this contribution. The second source of financial support came from the second annual Vendor Fair which was held in conjunction with the Medical Chemistry Sympoisum in ______. This event raised ______and the following companies participated. b) 2005 Chair's Goals and Assessment:

1. Goal: Start a Northeastern Section Women’s Chemist Committee

Assessment: Over the past years, NESACS has not had a formalized Women's Chemist Committee due to the fact that women are very active already in all aspects of our Section. Not only are women active but also they are enthusiastically encouraged and supported. In 2005, the NESACS WCC was formed and the chair of this committee was Dr. Cassandra Celatka from Genzyme. This year the Women's Chemist Committee co-sponsored the Golf Tournament, the

24 Networking/Social Events, and the Bike Ride. A flier was circulated at these events, which is copied below.

The Northeastern Section of the American Chemical Society Women Chemists Committee

The mission of the Women Chemists Committee is to be a leader in attracting, developing, and promoting women in the chemical sciences and related disciplines. The committee is comprised of women and men from academics, industry, and government.

Planned events for 2005: Co-sponsoring the Chair networking event at the Harpoon Brewery, Golf Tournament at a local course

Please sign up to be included on our mailing list. For more information please contact: Cassandra Celatka, chair NESACS WCC [email protected]

The WCC also interacted with the Graduate Women in Science Committee from MIT and publicized all of their events. I believe that co-sponsoring the above events was a good way to draw attention to this new NESACS committee and a positive way to recruit members. I know that our 2006 Chair, Pam Mabrouk, is very interested in continuing the development of this committee.

. 2. Goal: Organize four networking /social events

Assessment: The main focus of my year as Chair was to engage participation in NESACS through networking/social events. As described in detail above, there were four networking and social events in 2005, which included two brewery tours/dinners, a bike ride, and a golf tournament. All of these events were very successful and certainly served the purpose. For example, a person who attended the 1st Networking/Social event, who does not usually participate in NESACS activities, was the person whom planned and organized the bike event. I believe that if we offer opportunities for chemists to interact in a non-typical arena, we can encourage people to get involved in the ACS and to support the Strategic Thrusts of our Society.

3. Goal: Hold a golf tournament co-sponsored by the WCC. This event will be used for social / networking as well as a fundraising event for the Section. . Assessment: This event as described above was a huge success for three reasons: 1. This event recruited many players who are not typically in attendance at NESACS events. 2. It was a significant source of fundraising for the Section. 3. The tournament was a terrific format for networking. Many contacts were made on the course that day. I have already had many inquires about the 2006 tournament and I believe that we will be able to double the participation from 2005. a) 2006 Local Section Goals (Include at least three goals):

25 NESACS has a very stable, dedicated and talented Board of Directors made up of about eighty active members. Many of the active participants are older chemists and a large number are retired or nearing retirement age. There is a significant body of student chemists, academic chemists, and industrial chemists in our section but very little participation by these groups in the monthly meetings or in the activities of section committees. Consequently I would like to work to expand and diversify the active membership of NESACS this year. To do this, I think we need to: 1. identify opportunities for active participation 2. communicate these opportunities to current/new members 3. define current roles better (handbook defining roles/responsibilities) 4. grow/train up a core leadership within the section

b) 2006 Chair’s Goals:

Goal 1: Increase/improve communications with section membership by updating and changing the section’s method of managing the section’s website;

Goal 2: Increase number of active participants in section committees and activities by better communicating to section members potential opportunities for active involvement in the life of the section by developing and disseminating a brochure describing section activities and committees seeking member involvement; and survey membership to determine what if any changes can be made to better meet the general membership’s needs – particularly interested in learning if there are ways we can better involve the large number of student chemists, academic and industrial chemists, and senior chemists in our section.

Goal 3: Facilitate the development and training of section leadership by revising and updating the section handbook – last updated in 2003.

D. Suggestions/Concerns

List any suggestions you have for the Local Section Activities Committee (LSAC). How can LSAC specifically help your section?

______

Listing of Core Strategies

Please refer to the numbers below when identfiying activities as they relate to the ACS Core Strategies

26 1 Providing Timely State-of-the-Art Chemical Information. 2 Serving as a Premier Professional Organization for Practioners of Chemistry. 3 Elevating Public Appreciation of Chemical Sciences and Technologies. 4 Changing the Defination of Chemistry to Encompass its True Multidisciplinary Nature. 5 Delivering a Dynamic and Integrated Portfolio of Products and Services. 6 Promoting Inclusiveness throughout the Chemical Enterprise. For more information on the Core Strategies or the ACS Strategic Plan 2004-2007 please visit www.chemistry.org.

27

ANNUAL REPORT Northeastern Section, ACS

PART II - APPENDIX 1

SUPPORTING DOCUMENTS FOR ACTIVITIES

http://www.nesacs.org

28

ANNUAL REPORT Northeastern Section, ACS

PART II - APPENDIX 1

SUPPORTING DOCUMENTS FOR ACTIVITIES

http://www.nesacs.org

29 APPENDIX 1 - SUPPORTING DOCUMENTS FOR ACTIVITIES

APPENDIX 1 - CONTENTS Supporting Documentation for Part II - Narrative

Activity 1 – 1st Annual Golf Tournament ...... 3

Activity 2 – Chair’s Networking and Social Events...... 6

Activity 3 – Connections to Chemistry ...... 11

Activity 4 – National Chemistry Week Activities...... 15

Activity 5 – German Exchange Program...... 19

Activity 6 – YCC Career Symposium and Career Fair...... 22

Activity 7 – NSCRC 2005...... 23

Activity 8 – Virtual Meetings...... 25

Activity 9 – Bike Event...... 35

Activity 10 – Summerthing ...... 37

30 SUPPORTING DOCUMENTATION: ACTIVITY 1

GOLF TOURNAMENT

From Calendar of Activities:

June 6 1st Annual NESACS String Scramble Golf Tournament Wentworth Hills Golf & Country Club, Plainville, MA

Sample e-mailing – GOLF EVENT

1st Annual Northeastern Section ACS String Scramble Golf Tournament

This event is co-sponsored by the Women Chemists Committee

Date: June 6, 2005 at 12 noon

Course: Wentworth Hills Golf and Country Club 27 Bow St., Plainville, MA www.wentworthhillsgolf.com

Fee: Prior to May 1, $110 per golfer, $75 for students After May 1, $120 per golfer

Fee covers: Greens fee, Cart, Prizes including longest drive, closest to the pin and first, second and third place, Lunch before golf and a Dinner buffet after golf

Visit the NESACS website (http://www.nesacs.org) for more information and the registration form

Questions? Contact Amy Tapper at [email protected] or Harry Mandeville at [email protected].

All proceeds from this tournament will go to support NESACS programs

31

32

33

SUPPORTING DOCUMENTATION: ACTIVITY 2

CHAIR’S NETWORKING AND SOCIAL EVENTS

From The Nucleus – January 2005

was co-sponsored by the Younger Chair’s First Event Chemists Committee (YCC) and the newly organized WCC (Women Network / Social Chemists Committee), this event drew Co-sponsored by the YCC and WCC a diverse group. Come out and network with other The evening began with a beer Boston area Chemists! tasting. The participants were able to Harpoon Brewery Tour and dinner at sample a variety of Harpoon’s beers the No Name Restaurant such as the India Pale Ale, and Winter Brewery Tour Warmer. The tasting was followed by a Thursday, January 27th from 5:30 very educational lecture explaining the – 7:00 PM history of beer fermentation given by Harpoon Brewery, 306 Northern the Quality Control Manager of Harpoon Ave., Boston Brewery. In addition to the beer Dinner: history lesson, the lecture included the Immediately following the tour details of the four main components of No Name Restaurant, 15 Fish Pier, beer: water, barley, hops, and yeast. An Boston interesting fact learned from the lecture Reservations must be made no later was that hops were discovered in the than noon, January 20th. Please call or 1700’s and it was not only admired for fax Marilou Cashman at 800-872-2054 its flower, but also it acted as a natural or email at [email protected]. preservative. A great deal of time was There is free parking at both the Harpoon also spent discussing the water used in Brewery and the No Name the fermentation process. Interestingly, Restaurant, and both are accessible by Harpoon Brewery uses water straight public transportation. Visit the Harpoon from the Boston water supply. The lecture Brewery website for directions. was complete with barley tasting. (http://www.harpoonbrewery.com/ Participants were able to view the fermentation brewery/boston/directions/index.htm. tanks and also bought some Dinner will be immediately following souvenirs from the Harpoon store. the tour. Please visit the YCC website The brewery provided a great at http://www.nsycc.org for details on venue for people to socialize. In attendance the cost of the dinner.  was a large group from Ariad, as well as chemists from Genzyme, Astra Zeneca, Daiamed, Tufts University, Our Chair’s First Social Boston University, and visitors from as and Networking Event far as Connecticut. Immediately following the brewery Despite the record breaking snowfall lecture, the group enjoyed dinner at in January, the Chair’s first social the No Name Restaurant. Everyone and networking event was quite a success. partook in a traditional seafood dinner. Although the heavy snow earlier The response from this first event that week resulted in approximately was very positive. The next 50% cancellation, there were 35 in social/networking event will be held attendance for the Harpoon Brewery in April. Details of this event can be tour and dinner at the No Name found at www.nsycc.org and Restaurant. As this NESACS event www.nesacs.org. 

34

CHAIR‘S FIRST NETWORKING AND SOCIAL EVENT From the Web Site

NESACS SOCIAL EVENT The Chair's Second Social and Networking Event Beer Tasting and Dinner the Cambridge Brewing Company Thursday Nov 10, 5:30 p.m.

35

Sample E-Mailing:

Chair’s Second Social and Networking Event Co-sponsored by the YCC and WCC

Beer Tasting and Dinner at the Cambridge Brewing Company

Thursday, November 10th Tasting at 5:30 pm Dinner immediately following

All are welcome to attend

The beer tasting will be sponsored by

Reservations must be made no later than noon, Nov. 3rdth. Please call or fax Marilou Cashman at 800-872-2054 or email at [email protected].

Please visit http://www.cambrew.com/directions.htm for directions. Cambridge Brewing Company (1 Kendall Square, Building 100, Cambridge, MA 02139, 617-494-1994) is directly accessible by the T.

Attendees will be responsible for paying for their own dinner and beverages. http://www.cambrew.com/dinnermenu.htm

Sample e-mailing

May and June NESACS Social/Networking Events Bike (or Skate, Run or Walk) the Minuteman Bikeway

Date: Wednesday May 25 (Rain Date Thursday 26th) 2005

Time: Meet 6:15 PM for 6:30 Departure

Meeting Place: “Uncle Sam” Statue, Arlington Center (Mass Ave and Mystic St)

Please RSVP by May 24, or for more information: Email Joe Snodgrass at [email protected] or phone 617 494-0400, ext 235 We will ride at a leisurely pace up the beautiful Minuteman Bikeway (http://www.minutemanbikeway.org ) toward Lexington Green, and further if time allows. After returning to Arlington Center, we’ll share dinner and drinks at Kerry's Kitchen BBQ Grill.

36

1st Annual Northeastern Section ACS String Scramble Golf Tournament

This event is co-sponsored by the Women Chemists Committee

Date: June 6, 2005 at 12 noon

Course: Wentworth Hills Golf and Country Club 27 Bow St., Plainville, MA www.wentworthhillsgolf.com

Fee: Prior to May 1, $110 per golfer, $75 for students After May 1, $120 per golfer

Fee covers: Greens fee, Cart, Prizes including longest drive, closest to the pin and first, second and third place, Lunch before golf and a Dinner buffet after golf

For more information on these events please visit the NESACS website (http://www.nesacs.org)

From Golf Tournament Brochure

1st Annual Northeastern Section ACS String Scramble Golf Tournament

All proceeds from this tournament will go to support NESACS programs (http://www.nesacs.org)

This event is co-sponsored by the Women Chemists Committee

Rules

37

This is a best ball scramble. Each golfer will hit his own drive. The team will select the ball they wish to play for their second shot. All golfers will hit the next shot from this location (within one club length, no closer to the hole, no improving the lie) and so on until the ball is holed. Putts must be played from the exact spot of the chosen ball. A single score for the team will be recorded for the hole.

This is a string scramble. We will be selling pieces of string in lengths of 1” ($1), 3” ($2), 6” ($3) and 12” ($5). If you leave a putt within the length of a piece of string you have purchased, you may count that putt as holed (and thereby save a stroke). The catch: you must buy all of your strings before you start and a string may only be used once. You are on the honor system (as you should be any way since you are keeping your own score).

We will also be selling “Mole-igans” for $5. Everybody needs an extra shot once in a while. Buy a Mole-igan (or 2 or 3) and use them when you really need them. Sorry only one extra shot per Mole-igan per player per 18 holes.

The Event

Your entry fee covers: Greens fee Cart Prizes including longest drive, closest to the pin and first, second and third place Lunch before golf Dinner buffet after golf

A cash bar will be available before and during dinner.

Questions? Contact Amy Tapper at [email protected] or Harry Mandeville at [email protected].

38

SUPPORTING DOCUMENTATION: ACTIVITY 3

CONNECTIONS TO CHEMISTRY

Please see Appendix 5-A for a complete copy of the Connections to Chemistry program

From November 2005 Board Meeting Minutes

Education Committee: R. Tanner ‹ Connections to Chemistry 2005 The sixth Connections to Chemistry program was held at Burlington (MA) High School on Wednesday, October 19th. This program is designed to connect high school chemistry teachers with the numerous education resources that are available from the American Chemical Society. We again had an exceptionally good response to the program and closed the registration at 150 registrants. The 2005 President of the ACS, Dr. William Carroll, was at the opening session to welcome the participants to the program, and to encourage them to utilize the ACS resources and to consider affiliate membership in the Division of Chemical Education via the new Chemistry Teacher Connection (CTC) program.

In addition to the welcome, Dr. Carroll also presented one of the workshops for the program Why Don’t You Just Make All the Plastic Alike? In addition to this workshop, four other workshops were given: Toying with Chemistry, the National Chemistry Week workshop (John Mauch, Chemistry teacher, Belmont High School), It’s a small, small World, a nanotechnology workshop (Arthur Watterson, UMASS Lowell), Seeing the Unseeable, a technology workshop for enhancing demonstrations (Walter Rohr, Eastchester High School, NY), and Power from the Nucleus, a workshop on nuclear power and radioactive sources, (Gilbert Brown, UMASS Lowell; and David Barr, Seabrook Power Station).

The keynote address Do We Have a Future, or What? Wild Guesses What Chemical Education Will Be Like in 2015 was also given by Dr. Carroll. Following his address, door prizes were given which included subscriptions to J Chem. Educ., affiliate memberships in CHED, educational materials, ACS software, and ACS logo merchandise as well as certificates for professional development credits and a year’s subscription to ChemMatters.

An abstract has been submitted to the session on Professional Development of High School Chemistry Teachers to be presented at the ACS National Meeting in Atlanta, March 2006. The title of the presentation is: Six Years of Connections to Chemistry for High School Chemistry Teachers.

39 from the Web Site

"Connections to Chemistry" at Burlington (MA) High School

Oct. 19, 2005

(l-r) Ruth Tanner, University of Massachusetts Arthur Watterson, University of Lowell; Bill Carroll, ACS President; Amy Massachusetts Lowell Tapper, NESACS Chair

Arthur Watterson, University of Massachusetts (center) John Mauch, Braintree (MA) High Lowell School

(center) John Mauch, Braintree (MA) High Bill Carroll, ACS President School

40

Walter Rohr, Formally from Eastchester Bill Carroll, ACS President (NY) High School

(l-r) David Barr, Seabrook Power Station; Gilbert Bill Carroll, ACS President Brown, University of Massachusetts Lowell

(center) John Mauch, Braintree (MA) High Bill Carroll, ACS President, with Rebecca School Sansom, Belmont (MA) High School

(l-r) Ruth Tanner, University of Amy Tapper, NESACS Chair, with Bill Carroll, Massachusetts Lowell; Bill Carroll, ACS ACS President President; Amy Tapper, NESACS Chair

41

(l-r) Martin Isaks, University of Massachusetts Lowell; Ruth Tanner, University of Julie Kong, Salem (MA) High School, with Massachusetts Lowell; Bill Carroll, ACS Bill Carroll, ACS President President; Amy Tapper, NESACS Chair mm 10/28/05 SUPPORTING DOCUMENTATION: ACTIVITY 4

NATIONAL CHEMISTRY WEEK

REFERENCE: ACTIVITY NO. 3 Connections to Chemistry program in Appendix 5-A of the 2005 Annual Report

42 43 From the Web Site

......

About National Chemistry Week

National Chemistry Week (NCW) is an annual event celebrating the contributions of chemistry. The celebration originated in 1987 as National

Chemistry Day and by 1989 had grown into an Please contact entire week of activities. During National Prof. Christine Jaworek- Chemistry Week, local sections of the American Lopes

Chemical Society organize activities that correspond to an annual theme. Events are held Find out about Nationwide NCW activities! at museums, schools, libraries, shopping malls, and businesses nationwide.

This year, as in the past, the Northeastern Section of the American Chemical Society National Poster (NESACS) will hold events in the Boston area. Competition Descriptions and photos of previous years' events and plans for this year can be accessed by The Northeastern choosing the appropriate button above. Section of the ACS is participating in the National Poster As always, volunteers are welcome. If you would Competition. like to participate in National Chemistry Week as a volunteer, please contact Prof. Christine SEE GUIDELINES Jaworek-Lopes by email at Students in grades [email protected] or by phone at K-12 are eligable (617)264-7614. to participate. SEE POSTERS

44

Undergraduate Day Program

The Fourteenth Annual ACS Northeast Regional Undergraduate Day

Saturday, November 5, 2005

Hosted by the Department of Chemistry, Boston University, and Chemia Sponsored by the Northeastern Section of the American Chemical Society

9:00 Registration (Life Sciences and Engineering Building, 24 Cummington St., Boston)

9:30 Welcoming Remarks Professor Guilford Jones, Chair, Chemistry Department, Boston University Ruth Tanner, Northeastern Section of the ACS Deborah Jue, President, Chemia (ACS Student Affiliates Chapter at B.U.)

9:45 Keynote Address: Dr. Michael Gilbert, EIC Laboratories: “Electrically Releasing Adhesives Using Nanostructured Epoxies”

10:30 Coffee break

10:45 Research Talk Professor Nolan Flynn, Wellesley College: “From Nanoscience to Biomaterials: New Avenues in Chemical Research”

11:30 Workshop and Seminar (choose one) Professor Alex Golger, Boston University: “Demonstrations in Chemistry to Fascinate Kids” Professor Scott Schaus, Boston University: “Choosing a Graduate School”

12:00 Résumé Review and Graduate School/Industry Fair Dr. Frank Wagner, Strem Chemicals: “Preparing Your Résumé”

Graduate School and Industry Fair (12:00–1:15 p.m.)

12:30 Lunch

1:15 Research Talk: Professor John Porco, Boston University: “Biomimetic Synthesis of Complex Molecules”

2:00 Student Affiliates Workshop and Seminar (choose one)

45 Professor Anthony Fernandez, Merrimack College: “Resuscitating a Shallow–Breathing Student Affiliates Chapter” Dr. Adam Yeager, Boston University, CMLD: “Development of Chemical Libraries Using Parallel Synthesis” (includes a tour of the B.U. Center for Chemical Methodology and Library Development)

2:45 Adjournment

From the Nucleus

NESACS NCW Poster Winners Congratulations to Lori Merlo from Job Lane Elementary in Bedford, MA and to Tayla Thomes from Merry Deb Nursery School Inc in Braintree, MA for winning the Section NCW Poster Competition in the Grade Category 3- and K-2 Category respectively. 

From Board meeting minutes

‹ The Fourteenth Annual ACS Northeast Regional Undergraduate Day The Northeast Regional Undergraduate Day was held at Boston University on Saturday, November 5, 2005. The keynote address Electrically Releasing Adhesives Using Nanostructured Epoxies was given by Prof. Michael Gilbert of EIC Laboratories. Additional presentations were name by Prof. Nolan Flynn of Wellesley College, Prof. Adam Yeager of Boston University, and Prof. John Porco of Boston University. Among other activities were the Graduate School and Industry Fair, and workshops on choosing a graduate school and on increasing the activities of the student affiliates.

46

SUPPORTING DOCUMENTATION: ACTIVITY 5

GERMAN EXCHANGE PROGRAM

From the Nucleus

Sarah Chobot, a graduating senior at Boston University who is doing research with Professor Sean Elliiott, was awarded the prize for the best oral presentation at the 2005 Frühjahrssymposium of the Jungchemiker- forum (JCF) of the Gesellschaft Deutscher Chemiker (GDCh) that was held in Berlin, Germany, April 7-9. Sarah's prize consists of a cash award of 250 euros (~$325) and a flight ticket to attend any scientific meeting in the world during the next year.

Sarah was a member of the delegation of twelve students from NESACS that attended the Früh- jahrssymposium; her talk was entitled, "Electrochemical Studies of Thioredoxin and Thioredoxin Reductase - Gaining Insight into Molecular Mechanisms Affecting Oxidative Stress." Oral pre-sentations were also made by Pia Lopez (Schrock), M.I.T. (graduate student); Will Neeley (Essigmann), M.I.T. (graduate student); Alex Taylor (Schreiber), (graduate student). Poster presentations were made by Liz O'Day (Kantrowitz), Boston College (undergraduate student); Rukman De Silva (Kull), Dartmouth College (graduate student); Tim Gay (Tullius), Boston University (graduate student); Ivan Korendovych (Rybak- Akimova), Tufts University (graduate student); Xiaoguang Lei (Porco) Boston University (graduate student); Liz Vogel (Imperiali), M.I.T. (graduate student); Dan Kennedy (Planalp), University of New Hampshire (graduate student); Amritanshu Sinha (Schrock), M.I.T. (graduate student).

A poster presentation was also made by Lauren Wolf (Georgiadis), Boston University (graduate student). She attended as the Immediate Past Chair of the NESACS Younger Chemists Committee; the current NESACS- YCC Chair is Ivan Korendovych.

A poster on the NESACS educational programs was also presented by Morton Hoffman (Boston University), Ruth Tanner (University of Massachusetts Lowell), Mike Strem (Strem Chemicals, Inc.), Amy Tapper (Peptimmune, Inc.), and Lauren Wolf. Because of other commitments, Amy was not able to attend.

The meeting afforded the opportunity for the organizers of the NESACS-YCC and the GDCh-JCF to meet and make plans for the program beyond this exchange, which has been an annual event since 2001. Morton Hoffman, Chair of the ACS Division of Chemical Education, met with his counterpart of the GDCh (Prof. Franz-Peter Montfors, Universität Breman) to plan cooperative educational programs.

47

From the Nucleus

At the farewell dinner for the NESACS-YCC delegation last Saturday night in Berlin, Prof. Henning Hopf, President of the Gesellschaft Deutscher Chemiker (GDCh) presented Mike Strem with the Golden GDCh Pin for his work in promoting the cooperation between the GDCh and the ACS.

As a member of the ACS Board of Directors in 1998, Mike was instrumental in the founding of the German- American Frontiers of Chemistry series of symposia, which has now been expanded to include the Royal Society of Chemistry of the United Kingdom in a Trans-Atlantic Frontiers series. Mike was the initial driving force in the establishment of the exchange of young chemists between the GDCh and NESACS, and has been a member of the GDCh since 1991.

The Golden Pin was established by GDCh in 1995 to recognize members and non-members who have rendered outstanding service to chemistry and the chemical society. Mike is the third person to receive the Golden Pin; previous awardees are Prof. Rolf Sammet, the former CEO of Hoechst, and Prof. Wilhelm Fresenius, the former President of the Fresenius Institute.

From the YCC Report

Fifth Annual NESACS-YCC/GDCh-JCF Exchange Program (April 3-10)

This year's week-long exchange between the Gesellschaft Deutscher Chemiker-Jungchemikerforum (German Chemical Society - Younger Chemists Committee) and the Northeastern Section Younger Chemists Committee, held during the week of April 3, was a great success. Ten graduate and two undergraduate student from colleges and universities in the Boston area (Harvard, MIT, BC, BU, Tufts, Dartmouth College, University of New Hampshire) have traveled to Germany to participate in the 5th NESACS/GDCh exchange program. . . .

. . . The meeting afforded the opportunity for the organizers of the NESACS-YCC and the GDCh-JCF to meet and make plans for the program beyond this exchange, which has been an annual event since 2001. Morton Hoffman, Chair of the ACS Division of Chemical Education, met with his counterpart of the GDCh (Prof. Franz-Peter Montfors, Universität Breman) to plan cooperative educational programs.

48 Call for Applications – 2006

CALL FOR APPLICATIONS YCC/NESACS–JCF/GDCh Exchange to Germany March 12–19, 2006

The Younger Chemists Committee (YCC) of the Northeastern Section and the NESACS Education Committee invite applications from undergraduate and graduate students of chemistry, biochemistry, and chemical engineering at colleges and universities within the Section to spend a week in Germany as the guests of the Jungchemikerforum (JCF) of the Gesellschaft Deutscher Chemiker (GDCh). The exchange group will consist of up to 12 students and a number of faculty and industrial representatives. The trip to Konstanz (Baden-Württemberg), which is on the Bodensee at the border with Switzerland, will take place March 12-19, 2006. The visit will include a student chemistry research conference (Frühjahrssymposium), symposia on careers, education, and international opportunities, visits to industrial and scientific institutions, and the opportunity to engage in extensive networking with German and other European students. Each student representative from the U.S. will be expected to make a poster or oral presentation on his/her research at the Frühjahrssymposium, and upon return at the Northeast Student Chemistry Research Conference (NSCRC) on Saturday, April 22. Travel expenses will be provided by NESACS; accommodations in Germany will be covered by GDCh. A working knowledge of German, while useful, will not be specifically required; the language of the Frühjahrssymposium and other events will be English. Application forms are available from department chairs and on the YCC and NESACS websites. The following material must be submitted with the application form: the abstract of the presentation to be made at the Frühjahrssymposium and the NSCRC, an essay on the relevance of the exchange to the student’s professional goals, a letter of recommendation from the student’s research supervisor, and the approval of the supervisor and the chair of the department of the student’s absence from classes, the research laboratory, and other responsibilities. In addition, finalists will be interviewed by members of the Organizing Committee. For more information, contact Dr. Michael Strem, Chair of the Organizing Committee, at .

Deadline for receipt of applications: November 1, 2005

49 SUPPORTING DOCUMENTATION: ACTIVITY 6

YCC CAREER SYMPOSIUM AND CAREER FAIR

From the YCC Report

I. Overall Evaluation

Followed by expansion in 2004 the Northeastern Section Younger Chemists Committee (NSYCC) in 2005 focused on improving organization of several new events introduced in previous years to lay solid foundation for future expansion. We have also much improved organization of our new event, Northeast Student Chemistry Career Fair (NSCCF), which this year drew ~120 younger chemists. We have requested a pre-registration with returnable deposit, which worked exceptionally well. This year we held thee workshops run concurrently with the job fair this year. This format proved to be very good resulting in better time management – the attendees could easily come to the resume review sessions, visit company booths and learn more about interviewing techniques based on their own schedule. It also helped to distribute workload for the ACS Career Services representatives over time. Several of the attendees came away from the event with job interviews and offers (see below). In fact demand for resume review and mock interview exceeded our expectations and even 4 ACS Career Services representatives had to work at full capacity to help younger chemists improve their resumes. In 2006 we plan to get more ACS career representative for our event.

50 SUPPORTING DOCUMENTATION: ACTIVITY 7

NSCRC 2005

From the YCC Report

This year NSCRC moved to a different location for the first time in seven years. The Ray and Maria Stata Center at MIT provided exceptional facilities for the conference at a lower price than BU. It also helped to attract new students. The NSYCC met its goals this year in the planning of the NSCRC. NSCRC 2005 was a great success in terms of attracting new students and improving organization.

Program Schedule:

8:30am - 9:00am Poster Set-Up and Registration, Breakfast

9:00am - 9:15am Welcoming Remarks (Kirsch auditorium, room 123)

9:15am - 9:30am German Exchange Presentation

Will Neeley (MIT) 9:30am - 9:50am Formation of 2-Aminoimidazolone and Urea in DNA as a Consequence of 7,8-Dihydro oxoguanine Oxidation Provides Potent Sources of Point Mutations in Vivo

9:50am - 10:10am Sarah Fischer (University of Massachusetts at Lowell)

51 Scope and Limitations of the Reaction of Potassium Hyride with Thiones

Sarah Chobot (Boston University) 10:10am - 10:30am Characterization of Thioredoxin Systems Via Protein Film Voltammetry

10:30am - 10:50am Coffee Break

Sonia Taktak (Tufts University) 10:50am - 11:10am Olefin epoxidation and aromatic hydroxylation promoted by biomimetic amino-pyridine iron complexes - effect of coordination sphere and nuclearity.

Christopher Gilmore (Boston College) 11:10am - 11:30am The Synthesis of 4(R)-hydroxy-L-proline-glycine Alkene Isostere.

Erin Prestwich (Boston College) 11:30am - 11:50am Amino acid promoted DNA cleavage.

11:50am - 12:30pm Lunch

12:30pm - 1:30pm First Poster Session

1:30pm - 2:30pm Second Poster Session

Keynote Address: Dr. David Walt of Tufts University: 2:30pm - 3:30pm "Optical Sensor Arrays: From Molecular and Cell Biology to Artificial Olfaction".

3:30pm - 3:50pm Awards Presentation

3:50pm - 4:00pm Closing Remarks, Poster Take-Down

This conference is being sponsored by:

52 SUPPORTING DOCUMENTATION: ACTIVITY 8

VIRTUAL MEETINGS

Announcement of the E-section grant and meeting to discuss the project PAM 5/24/05 last amended 6/9/05

NESACS has just received funding from ACS National to develop an electronic local section or “E-section” to complement the current monthly activities. The idea is to take advantage of the opportunities for synchronous and asynchronous communication afforded by the world-wide- web in order to actively engage and involve more of our local section members in the American Chemical Society and the life of the Northeastern Section. We plan to supplement current local section activities with a variety of web-based mechanisms for interaction and communication including: The plan will be to develop and test an expanded NESACS website that includes: • Discussion board where members can discuss various chemistry-related topics including career issues (education (undergraduate, graduate), academe, industry)), topical (biotechnology, materials, etc.) • Semi-monthly series of on-line seminar programs on a variety of topics; • Monthly e-mail newsletter that notifies membership of new information and/or activities available on the website, monthly meeting, and other activities (special lectures, Chemistry Week, etc.); • Blog (web journal) focused on issues pertaining to chemists and chemical engineers; and a • Wiki (provides participants with ability to credit and edit web content themselves) for the chemistry community, with a special focus on New Englanders. It is anticipated that the addition of these multiple modes of web-based communication will enhance the membership experience of current members and provide an outreach to those who are not currently able to attend local section meetings.

Development of the E-section will be carried out by NESACS’ new webmaster, Mr. Sathish Rangarajan, in collaboration with a committee that will include self-identified members interested in partnering on the development of the E-section, the NESACS Chair, Amy Tapper, and the NESACS Chair-Elect, Patricia Mabrouk. Sathish has an MS in Organic Chemistry from U. Vermont (2005). Prior to earning his MS, Sathish was an advertising copywriter and web designer in India.

At this time, we would like to invite members who would like to discuss this project and who are potentially interested in partnering on it to attend a brief meeting Thursday June 16, 2005 at Northeastern University in room 115 Hurtig Hall at 3 pm. Directions to the Northeastern University campus and a map are available at URL: http://www.campusmap.neu.edu/map_page_4.html. Please e-mail Marilou Cashman ([email protected]) before June 13, 2005 if you would like to obtain a parking ticket. Anyone who is interested in participating in the project but are unable to attend the meeting should e-mail Pam Mabrouk ([email protected])

53

E-mails in preparation for virtual meeting

Some logistical details for the month of September.

1. Our regular monthly September Section meeting will be held on Sept. 22nd at 4:30 pm. This will be a virtual meeting. This year our Section was awarded an ACS Local Section Activities Innovative Grant for the formation of an “E-Section”. We will be using the discussion board on our website for this meeting. Details will follow on how to participate. Directions will be given on how to log on to the discussion board and this must be done in advance of the meeting. All committees must post their reports as file attachments on the discussion board in advance and a procedure for posting reports will be sent soon.

Please contact me with any questions.

Best regards, Amy

Amy Tapper, Ph.D.

On 8/26/05, Amy Tapper wrote:

Pam and Sathish,

Thank you for all of your efforts in getting this organized! I am suggesting the dates of Thurs., Sept 22nd and Thurs. Sept. 29th at 4:30pm for the discussion board. Please let me know which date you prefer.

Pam, thank you for volunteering to contact the board members. Once we choose the date, we should send the message asap to ensure that everyone has time to get “adjusted” to this new format.

I am contacting National to discuss any legal issues we should be aware.

I am leaving for the ACS meeting tonight, but will be available by Blackberry. Have a nice weekend,

Amy

-----Original Message----- From: [email protected] [mailto:[email protected]] Sent: Wednesday, August 17, 2005 3:23 PM To: Amy Tapper; Chorghade Subject: re: NESACS discussion board

Hi Amy and Mukund:

I am writing concerning progress on the discussion board. Sathish has set it up and it seems in good shape. All of the board members will need to register and, if I have your permission, I will write an e-mail and run it by you first so we can get the ball rolling on that and the September virtual board meeting. I will be out of the office from Sept 10-Sept. 18 but you are welcome to have the meeting during that time if you like J

54 Since we usually meet at 4:30 pm we could meet virtually during that time period for an hour on a Thursday. Any suggestions on when you would like to do this? I could also include in the e-mail a brief explanation of how the meeting would work. Basically I propose that you open it by creating a thread, type your message. Then anyone on the board who is on-line can submit a reply. You can allow a 1 minute to pass w/o reply and then move on. Voting on an issue could be accomplished by requesting each member to submit a written “reply.” Any thoughts, concerns?

We will need policies for the discussion board to work well and I think everyone will need to agree on them. I have drafted a document that could be used as the basis for discussion and am attaching it. Sathish has already told me that he would like the discussion board to be open to use by anyone ACS member or not – I am not sure how you feel or if we have any formal obligation legal or otherwise for it to be ACS members only.

Let me know what you think.

Best,

PamJ Mabrouk [email protected] (See attached file: Discussion Board Policies.doc)

______

THIS NOTE WAS RECEIVED FROM AMY TAPPER WITH A REQUEST THAT IT BE FORWARDED TO THE BOARD. AMY'S NOTE INCLUDES A REFERENCE TO AN ATTACHMENT. FOR THOSE WHO HAVE SOME DIFFICULTY WITH ATTACHMENTS, THAT INFORMATION HAS BEEN COPIED DIRECTLY INTO THIS E-MAIL AS WELL AS BEING INCLUDED AS A SEPARATE ATTACHMENT.

Marilou Cashman

Note from Amy Tapper:

Please forward to the board

Dear Board Members:

Our regular Sept. meeting will be held virtually on Sept. 22nd at 4:30 pm. As I look forward to partici- pating in this new format, I as well am not familiar with discussion boards and will need some time to get prepared. Please read Pam's instructions below. We ask for your patience in this "experiment" and look forward to a successful meeting!

Amy

On Thursday September 22, 2005 we will have hold the September 2005 NESACS Board meeting on-line on the new NESACS Discussion Board. This is an opportunity for us as a section to try something new and a bit different. Please be assured that we have no plans to move eliminate board meetings and/or to replace them with on-line meetings but this capability may make it easier for us to work with our individual committees and to have organized discussions at times other than when we hold our normal monthly meetings. So, take a deep breath and join us for something a bit different this month :)

Attached you will find directions (NESACS92205.doc) on how to log onto the discussion board, post your reports, as well as directions for how to participate in the meeting.

55 In order to fully participate you will need to have the following:a computer with internet access (LAN/WIFI/or modem) an internet browser such as Internet Explorer, Netscape, or FireFox Microsoft Word and Excel (to read file attachments from the various committees)

Please follow the directions and access the discussion board in advance of the date of the meeting. We will be holding a practice meeting at 5 pm on Monday September 19, 2005. Please feel free to log on at that time period if you wish to practice. We will use the "Admin - Test Thread" for the practice run.

To make things go more smoothly the leadership of NESACS is asking everyone to post their committee reports on or before Monday September 19, 2005 so that everyone will have ample time to be able to go on-line and read all of the posted reports before the Thursday September 22, 2005 virtual board meeting.

If you have any questions, please e-mail Pam Mabrouk ([email protected]) or the NESACS webmaster Sathish Rangarajan ([email protected]). Note that Pam Mabrouk will be out of the office from September 10 – September 18, 2005.

(See attached file: NESACS92205.doc) -- Attachment copied below:

Directions for Participation in the September 22nd 2005 Virtual Board Meeting

1. To participate all board members will need to register first. Please do this in advance of the virtual board meeting. To do this type in or copy and paste the following URL into your web-browser: http://www.nesacs.org/discuss/register.php?

2. To access the NESACS discussion board type or copy and paste the following URL into your web-browser:

3. The Board Members forum named “Board Members” (identified by a red arrow in the screen shot shown above) is password protected. The password is: invit2005

4. To access the “Board Members” discussion board, simply click once on the underlined text “Board Members” (indicated by a red arrow in the screen shot shown above). Your screen should now look like

the one shown below:

5. For readability and ease in following the discussion, separate threads have been created for each new topic/committee report. For your information, a new thread is created by clicking the “New Thread” button below the list of threads (identified by the red arrow in the screenshot shown below). Please do not create any new threads. 6. To view subsequent posts on this thread simply slide the slide bar (identified by the red arrow) down.

7. To view and participate in the discussion posted on a thread, click on the underlined text in the “Thread/Thread Starter” box. For example, to view and participate in the discussion topic “Admin – Test thread” click once on the underlined text “Admin – Test thread” (identified by a red arrow in the screen shot shown below).

8. Each person wishing to add to the discussion on a thread, can post their thoughts/questions by clicking the “Post Reply” button that appears at the bottom of the discussion under a thread (identified by a red arrow in the screen shot shown above).

9. If you wish to quote all or part of the previous poster’s post in crafting your reply, simply press the “Quote” button at the lower right (identified by the red arrow in the screen shot shown below):

10. Once you press the quote button, your screen should look like the one below. The text from the previous poster will appear inside the message dialogue box between two sets of html tags ([QUOTE=”name of previous poster”]…/[QUOTE]). Simply type your reply underneath this text within the dialogue box.

56 When you are finished, you may preview your post by selecting (clicking once) the button “Preview Post” that appears at the bottom right of the dialogue box. If you are satisfied with your post and don’t need to preview it simply select the “Submit Reply” button that appears to the immediate left of the “Preview Post” button.

11. To include a file attachment containing for example the text of a committee report summary in your posting, press the “Manage Attachments” button near the bottom of the “Additional Options” dialogue box (indicated by a red arrow in the screen shot shown below):

Note that compatible file formats include: bmp, doc, gif, jpe, jpeg, jpg, pdf, png, psd, txt, and zip This will open a new dialogue box entitled “Manage Attachments” (shown below)

Click the “Browse” button to find the file on your hard drive that you wish to upload onto the discussion board. Click the “Upload” button located to the right of the “Browse” button when you have found your file. Click the “Close this window” button when you are finished uploading your file.

12. Amy will post “End of discussion on this thread” to signal the end of discussion on a topic.

13. To return to the main “Board Members” page select “Board Members in the “Forum Jump” menu box shown at the lower right of your screen (indicated by a red arrow in the screen shot shown below) and press the “Go” button immediately to the right.

14. This will return you to the main “Board Members” forum page where you will be able to access the next new discussion thread.

15. At the end of the meeting, simply close your browser using the “X” box at the upper right of your screen.

57

58 59 60 61 NESACS Board Meeting Monthly Meeting Held via an internet forum September 22, 2005

Members in Attendance: D. Lewis, P. Mabrouk, J. Piper,D. Rickter M. Singer, and A. Tapper.

The meeting was called to order at 4:30PM with A. Tapper as the Chair.

As part of a local section grant, the September meeting of the NESACS Board of Directors was held via an Internet forum. Members of the Board were sent instructions on how to post reports, how to communicate amongst the members and how to vote. The participants in the Internet forum were able to communicate to one another as described in the instructions.

A quorum was not reached and the meeting will be rescheduled. The meeting was adjourned at 4:55PM.

Respectfully Submitted

Michael Singer Secretary – NESACS

NESACS Board Meeting Monthly Meeting Held via an internet forum October 11th, 2005

Members in Attendance: M. Froimowitz, I. Korendovych, P. Mabrouk, J. Piper, M. Singer, and A. Tapper

The meeting was called to order at 4:30PM with A. Tapper as the Chair.

As part of a local section grant, the September meeting of the NESACS Board of Directors was held via an Internet forum. Members of the Board were sent instructions on how to post reports, how to communicate amongst the members and how to vote. The participants in the Internet forum were able to communicate to one another as described in the instructions.

A quorum was not reached and the meeting was adjourned at 4:45PM.

Respectfully Submitted

Michael Singer Secretary – NESACS

62

SUPPORTING DOCUMENTATION: ACTIVITY 9

BIKE EVENT

From Calendar of Activities: May 25 YCC Bike Event – Minuteman Bikeway

Sample e-mailing – BIKE EVENT

May NESACS/NESACS-YCC Event Bike (or Skate, Run or Walk) the Minuteman Bikeway

Date:Wednesday May 25 (Rain Date Thursday 26th) 2005 Time:Meet 6:15 PM for 6:30 Departure Meeting Place:"Uncle Sam" Statue, Arlington Center (Mass Ave and Mystic St) Parking:Ample parking in Arlington City lots near Arlington Center. Also well-served by public transportation. Please RSVP by May 24, or for more information:Email Joe Snodgrass at [email protected] or phone 617 494-0400, ext 235

Light colored clothing, reflective vests and bands, lights and helmets highly recommended!

We will ride at a leisurely pace up the beautiful Minuteman Bikeway toward Lexington Green, and further if time allows. After returning to Arlington Center, we'll share dinner and drinks at Kerry's Kitchen BBQ Grill. What is the connection between bicycling and chemistry? Well, bring YOUR ideas on that, but at least one historical anecdote will be revealed!

If you don't have a bike and want to ride, it may be possible to arrange for a loaner bike. If you'd rather skate, run or walk the Minuteman is a multi-use facility come along and meet up with the group afterwards! The bikeway is also wheelchair accessible and usable.

63

64 SUPPORTING DOCUMENTATION: ACTIVITY 10

SUMMERTHING

SUMMERTHING 2005 Wallace J. Gleekman, Chair

The Northeastern Section of the American Chemical Society maintained its close relationship with the Boston Red Sox who had provided NESACS members with group tickets when tickets were in high demand and difficult to obtain. Games that were made available to NESACS members in 2005 were with the Atlanta Braves, Anaheim Angels, Cleveland Indians, Minnesota Twins and Oakland Athletics.

Part I: May 21, 2005; Red Sox vs. Atlanta; Final Score: Red Sox 5 Braves 7

On a cold raw evening after a rain delay of 30 minutes, Atlanta went out to a 7-0 lead and then held on as the Red Sox tried to rally in a light continuous rain but, alas, it was too little too late. The Red Sox committed four errors during the game. Edgar Rentaria made two errors, Bill Meuller and Mark Bellhorn one each. Tim Wakefield allowed eight hits and six runs in five innings. The Braves’ Kyle Davis who was just promoted from AAA Richmond, toyed with Red Sox for five innings throwing 95 pitches and allowing four hits.

In the 6th inning trailing 7-0, the Sox scored two runs when Kevin Millar singled. In the 7th the Sox scored a single run when Manny Ramirez forced David Ortiz scoring Rentaria. In the 9th Boston made it interesting when Johnny Damon singled, David Ortiz walked, Ramirez doubled scoring Damon and Trot Nixon grounded out scoring Ortiz. But Jason Varitek flied out to left field ending the game. Most of the damp shivering 35,008 fans had left by the end of the seventh inning.

Part II: June 5, 2005; Red Sox vs. Anaheim; Final Score: Red Sox 6 Angels 3

65 Before a sellout crowd of 35,095 the Red Sox hit into three inning ending double plays (first, sixth, eighth), their first four hitters gathered only three hits in14 tries while striking out seven times and were outhit by the Angels 10 to 8. Yet the Boston bullpen (Mike Myers, Mike Timlin and Keith Foulke) kept the door closed as the Sox scored three runs in both the fourth and seventh innings. Wade Miller, the Boston starter, allowed nine hits into the seventh inning leaving with a 3-3 tie on 110 pitches.

The Red Sox had scored their first three runs on three hits, two walks and a sacrifice fly. In the seventh, Bill Meuller was hit by a pitch to start the rally, John Olerud singled and Jay Payton singled to load the bases. Mark Bellhorn hit a sacrifice fly to give the Sox the lead and then David Ortiz doubled scoring Olerud and Peyton. The win bolstered the Red Sox home record to 17-9, the best in the American League East.

Part III: June 28, 2005; Red Sox vs. Cleveland; Final Score: Red Sox 8 Indians 12

The Red Sox had it after six innings (8-5) and then blew it. And it was their reliable relief pitcher, Keith Foulke, who yielded five runs in 1 2/3 innings and allowed the Indians Travis Hafner to slice a bases loaded home run just inside the Pesky Pole in right field. This homer handed the Red Sox their first loss when leading after eight innings since July 19, 2004. The crowd of 35,445 lustily booed Foulke for his lackluster performance. The loss also cut the Bosox lead in the AL East to 1 1/2 games over Baltimore.

After trailing 4-1 in the fifth, the Sox rallied for two in the fifth and five in the sixth. In the sixth Jay Payton singled, Kevin Youkillis doubled, Johnny Damon singled, Edgar Renteria walked, David Ortiz singled, Manny Ramirez singled and Kevin Millar singled. But two runs for the Indians in the eighth and five runs in the ninth spelled doom for the Red Sox. It was the third blown save for Foulke who boosted his earned run average to over 6. Wade Miller, the Boston starter, had not competed a game in all of June. To make matters even worse, in the ninth all three Sox batters grounded out on the first pitch. It was a three pitch inning for Bob Wickman. The only bright spot for the Sox was the three hits for Ortiz.

Part IV: July 30, 2005; Red Sox vs. Minnesota; Final Score: Red Sox 6 Twins 2

The BIG news for this game was not the starting pitcher David Wells, the fact that Edgar Renteria did not make an error, that the Sox remained in first place 2 1/2 games in front of the Yankees, that Johnny Damon got three hits to raise his batting average to .340 but that Manny Ramirez was not in his usual left field position. It was the second time in the last three games that he failed to play. First baseman Kevin Millar was in left field and John Olerud was playing first and batting cleanup. Wells was upset and let everyone especially the media know about it.

With Ramirez out, David Ortiz walked three times but Olerud was up to the task and batted in three runs. The Sox pounded out 14 hits en route to their 6-2 victory, their 12th in their last 13 games. The game also marked the return of outfielder Gabe Kapler after an injury getting 2 hits in 4 at bats. Wells pitched seven scoreless innings retiring 13 consecutive batters before yielding two runs. It was delightful game for the 35,167 loyal fans who witnessed it.

Part V: September 17, 2005; Red Sox vs. Oakland; Final Score: Red Sox 2 Athletics 1

With the Red Sox win over the Athletics 2-1, the Sox maintained their 1 1/2 game lead over the Yankees for first place. Bronson Arroyo, Boston’s starting pitcher, gave up three hits and one run over seven innings for his 13th victory. Jon Papelbon and Mike Timlin finished up allowing just one Oakland hit. Manny Ramirez singled in the first Red Sox run in the first inning and then provided the winning run with a towering home run over the left field wall in the sixth inning. Boston’s first run came when Edgar Renteria singled, David Ortiz singled and then Ramirez singled.

66 Arroyo had one difficult inning - the 5th - when he used 30 pitches. The A’s had two on and no out and then the bases loaded with two outs but managed only to tie the game at 1-1. Renteria committed his 28th error, tops in the major leagues. The Sox keep winning the close ones; yesterday 3-2 and today 2-1. The Red Sox won 15 of 19 games that had been decided from the 7th inning on. A delighted sellout crowd of 35,220 celebrated with a rousing chorus of “Sweet Caroline” during Boston’s eighth inning

67

ANNUAL REPORT Northeastern Section, ACS

APPENDIX 2

BUDGETS LONG-RANGE PLAN

http://www.nesacs.org

68 APPENDIX 2 - BUDGETS AND LONG-RANGE PLAN

REPORT OF THE TREASURER - 2005 James U. Piper, Treasurer

Page 1 of the financial report reflects the transactions in the operating account of the Section. In addition to the operating account, the Trust Funds operate under the supervision of the Board of Trustees. The operating account generally pays all bills and then requests reimbursement of Trust-related expenses from the Trustees. In 2005, those reimbursements totaled $65,600.29 (line 10). Since the Trust funds are separately maintained, the calculation of the Public Support ratio on page 2 of the Financial Report is incorrect. The correct calculation is on the attachment to the Financial Report.

Although the Section ran a small operating deficit in 2005, this is offset by an increase in outstanding reimbursements due from the Trust accounts. At the end of 2004, $28,410 was owed to the Operating Account by the Trust accounts. At the end of 2005, the amount due was $36,162.

A separate set of books is kept for the Nucleus, and these are maintained on an accrual basis. The financial results presented by the Board of Publications differ from those in the Treasurer’s report because the latter is presented on a cash basis.

The Attorney General of the Commonwealth of Massachusetts requires nonprofit organizations to file annual reports accompanied, in our case, by a review by a CPA. The review of the 2004 financial statements was completed in July, and the report was filed. Copies of forms 990 and 990T for 2004 were sent to the National ACS office.

James U. Piper Treasurer 2-A: Budgets BUDGET 2005

Northeastern Section Draft 01/13/05 Budget Proposal 2004 2004 2005 2005 2005 Annual Account # Budget Actual Requests Proposed Proposed From INCOME General Offsetting Acct National Allotment 10 29,195.00 29,195.00 29,859.00 Travel Grants 11 12,000.00 17,044.16 20,000.00 Local Dues 12 42,000.00 53,617.38 60,000.00 New-member Commission 13 50.00 0.00 50.00 Contributions 14 31,000.00 9,971.09 10,000.00 Other Program Income 15 8,775.00 18,557.00 10,575.00 Project SEED 16 6,000.00 0.00 2,850.00 Continuing Education 17 10,000.00 9,825.00 8,000.00 Dinner Receipts 18 7,000.00 9,547.25 7,000.00 Savings Interest 19 100.00 171.64 150.00 Miscellaneous 20 0.00 2,526.23 Trustees: Cons. Acct. 21 1,000.00 1,220.21 1,000.00 Perm. Inc. Acct. 22 9,000.00 14,995.17 8,800.00 Norris Inc. Acct. 23 30,100.00 19,158.89 23,250.00 Richards Inc. Acct. 24 14,000.00 12,565.82 8,850.00 Publ. Inc. Acct. 25 8,000.00 8,000.00

69 Hill Award 26 1,500.00 1,576.00 1,500.00 Esselen Award 27 14,000.00 15,195.00 14,000.00 Levins Award 28 700.00 0.00 700.00 Brauner Lecture 29 2,000.00 2,000.00 NERM 30 0.00 0.00 Summer Programs 31 2,500.00 2,464.00 500.00 2,000.00 Advertising 32 50,000.00 47,830.50 45,000.00 45,000.00 INCOME TOTALS 278,920.00 265,460.34 100,559.00 163,525.00 TOTAL 264,084.00 EXPENSE Chair 50 4,100.00 3,329.46 6,000.00 6,000.00 Business Office 51 1,850.00 1,102.40 1,350.00 Treasurer 52 5,600.00 11,655.06 5,600.00 800.00 4,800.00 22.00 Archivist 53 400.00 118.84 250.00 250.00 Publication 54 0.00 0.00 Nucleus 55 69,480.00 61,840.67 68,239.00 13,239.00 53,000.00 various Program 56 1,000.00 217.54 500.00 500.00 Ballots 57 1,850.00 1,782.30 1,850.00 Public Relations 58 750.00 365.10 1,000.00 Prof. Relations 59 1,200.00 0.00 1,200.00 0.00 Education 60 15,000.00 10,201.12 13,500.00 9,025.00 3,475.00 15.00 Newell Awards 61 1,000.00 1,021.13 1,000.00 1,000.00 22.00 Ashdown Awards 62 2,500.00 1,525.07 2,500.00 1,900.00 600.00 15.00 Continuing Education 63 8,000.00 8,550.34 8,000.00 17.00 Local Arrangements 64 15,600.00 20,425.56 8,600.00 7,000.00 18.00 Membership Committee 65 1,000.00 390.53 600.00 600.00 Hill Award 66 1,500.00 1,922.34 1,500.00 26.00 Norris Award 67 16,000.00 8,417.89 16,000.00 23.00 Speakers Bureau 68 400.00 0.00 400.00 400.00 23.00 Summer Scholars 69 13,700.00 11,313.47 13,700.00 13,700.00 23,24 Project SEED 70 12,000.00 3,873.00 6,188.00 3,350.00 2,850.00 16.00 Richards Medal 71 12,000.00 7,297.67 0.00 24.00 Esselen Award 72 14,000.00 15,042.58 14,000.00 27.00 Levins Prize 73 700.00 623.60 700.00 28.00 Sec. School Award 74 2,000.00 1,791.00 2,000.00 24.00 Aula Laudis 75 500.00 566.36 375.00 500.00 22.00 Trustees 76 1,000.00 625.96 1,000.00 21.00 Chair-elect 77 2,700.00 1,527.76 1,675.00 1,675.00 National Chem. Week 78 6,650.00 6,141.60 6,950.00 4,950.00 2,000.00 29.00 Summer Programs 79 2,000.00 2,146.00 2,000.00 31.00 ACS Scholars 80 2,700.00 2,500.00 2,500.00 2,500.00 22.00 Medicinal Group 81 7,500.00 2,205.89 7,500.00 5,500.00 Travel Grants 82 18,000.00 22,778.88 6,500.00 20,000.00 11.00 Adm. Secretary 83 18,000.00 17,002.75 @28 17,500.00 Miscellaneous 84 0.00 108.12 200.00 NERM 85 100.00 0.00 Younger Chemists Comm 86 9,600.00 9,499.80 12,100.00 4,600.00 6,500.00 15.00 Jung Chemiker 87 21,000.00 24,861.41 12,000.00 12,000.00 EXPENSE TOTALS 291,380.00 262,771.20 101,389.00 163,525.00 TOTAL 264,914.00

70 Northeastern Section 12/20/05 Budget Proposal, Draft 2005 2005 2006 2006 2006 Annual Account # Budget Est Actual Requests Proposed Proposed From INCOME General Offsetting Acct National Allotment 10 29,859.00 29,859.00 30,387.00 Travel Grants 11 20,000.00 17,769.00 20,000.00 Local Dues 12 60,000.00 55,335.00 55,000.00 New-member Commission 13 50.00 75.00 50.00 Contributions 14 10,000.00 12,700.00 10,000.00 Other Program Income 15 10,575.00 12,548.00 9,492.00 Project SEED 16 2,850.00 2,275.00 4,550.00 Continuing Education 17 8,000.00 6,685.00 7,000.00 Dinner Receipts 18 7,000.00 7,200.00 7,000.00 Savings Interest 19 150.00 180.00 180.00 Miscellaneous 20 0.00 1,955.00 Trustees: Cons. Acct. 21 1,000.00 626.00 1,000.00 Perm. Inc. Acct. 22 8,800.00 10,087.00 7,700.00 Norris Inc. Acct. 23 23,250.00 24,915.00 30,100.00 Richards Inc. Acct. 24 8,850.00 7,340.00 13,800.00 Publ. Inc. Acct. 25 8,000.00 4,021.00 6,000.00 Hill Award 26 1,500.00 532.00 1,500.00 Esselen Award 27 14,000.00 17,451.00 14,000.00 Levins Award 28 700.00 626.00 700.00 Brauner Lecture 29 2,000.00 2,000.00 NERM 30 0.00 Summer Programs 31 2,500.00 1,536.00 2,000.00 Advertising 32 45,000.00 30,000.00 40,000.00 40,000.00 INCOME TOTALS 264,084.00 243,715.00 95,617.00 166,842.00 TOTAL 262,459.00 EXPENSE Chair 50 6,000.00 7,728.24 2,500.00 2,500.00 Business Office 51 1,350.00 693.04 800.00 Treasurer 52 5,600.00 3,947.66 4,500.00 800.00 3,700.00 22 Archivist 53 250.00 0.00 200.00 200.00 Publication 54 0.00 0.00 Nucleus 55 66,239.00 61,000.00 62,273.00 15,273.00 46,000.00 see notes Program 56 500.00 977.53 3,500.00 3,500.00 Ballots 57 1,850.00 1,937.18 1,950.00 Public Relations 58 1,000.00 370.00 Prof. Relations 59 0.00 0.00 500.00 500.00 Education 60 12,500.00 12,500.00 12,650.00 9,058.00 3,592.00 15 Newell Grants 61 1,000.00 1,049.25 1,000.00 1,000.00 22 Ashdown Awards 62 2,500.00 1,672.42 2,500.00 1,900.00 600.00 15 Continuing Education 63 8,000.00 6,325.64 7,000.00 17 Local Arrangements 64 15,600.00 14,000.00 8,600.00 7,000.00 18 Membership Committee 65 600.00 423.49 600.00 600.00 Hill Award 66 1,500.00 1,231.33 1,500.00 26 Norris Award 67 16,000.00 22,550.00 16,000.00 23 Speakers Bureau 68 400.00 0.00 400.00 23 Summer Scholars 69 13,700.00 13,265.57 13,700.00 13,700.00 23 Project SEED 70 6,200.00 4,150.00 9,100.00 4,550.00 4,550.00 16 Richards Medal 71 0.00 0.00 12,000.00 24 Esselen Award 72 14,000.00 16,154.43 14,000.00 27 Levins Prize 73 700.00 640.83 700.00 28 Sec. School Award 74 2,000.00 1,745.00 1,800.00 24 Aula Laudis 75 500.00 489.36 375.00 500.00 22 Trustees 76 1,000.00 558.60 1,000.00 21 Chair-elect 77 1,675.00 1,236.68 1,700.00 1,700.00 National Chem. Week 78 6,950.00 6,175.45 7,000.00 5,000.00 2,000.00 29 Summer Programs 79 2,000.00 2,170.00 7,000.00 5,000.00 2,000.00 31 ACS Scholars 80 2,500.00 2,500.00 2,500.00 2,500.00 22 Medicinal Group 81 5,500.00 3,480.46 7,500.00 5,500.00 Travel Grants 82 26,500.00 24,157.84 6,500.00 20,000.00 11 Adm. Secretary 83 17,500.00 14,300.00 16,500.00 Miscellaneous 84 200.00 266.19 200.00 NERM 85 0.00 0.00 1,000.00 1,000.00 Younger Chemists Comm 86 11,100.00 8,000.00 10,920.00 5,620.00 5,300.00 15 Jung Chemiker 87 12,000.00 9,626.48 12,000.00 10,000.00 EXPENSE TOTALS 291,380.00 245,322.67 107,251.00 166,842.00 TOTAL 274,093.00

71 Notes to the Budget Proposal 12/20/05 Expense accounts for which budget requests were received are shown. The "From Account" column shows the income accounts which fund the "Offset" expense budget amounts. In the places where there are two numbers, the breakdown is shown below. The budget is in deficit by $11,634 to be made up from cash on hand on December 31.

14 Contributions. This is all corporate giving to the Section. 15 Other Program Income. Consists of the offsetting income from Education and YCC activities as noted in expense categories offset by account 15. 21-29 Trustees. Approval of the budget constitutes the approval to transfer the budgeted amounts from the Trust Funds for expenditures as indicated in the expense items. In addition, the National Norris Award will cost about $10,000. 52 Treasurer. $3,700 is for the CPA audits required by Massachusetts, $400 is for Corporate solicitations, and $400 for Treasurer's expenses. 55 Nucleus Budget Request. The Budget committee reduced the request by $1000.

EXPENSE: Two 16 page issues 8716.00 Four 20 page issues 20480.00 Two 24 page issues 10764.00 Two 28 page issues 11238.00 Ballots 2075.00 Ad Manager 10000.00 Business Manager 2100.00 Office & Committee expense 1400.00 Web Page 500.00 67273.00 INCOME: Advertising 40000.00 Publications Trust 6000.00 Norris Award Fund (In line 67 budget) 5000.00 General Funds (55) 16273.00 Budget Comm 15273 67273.00 60 Education. The Budget request for $12,650, includes $500 for May meeting expenses, $1800 for Undergraduate Day offset by $1000 income, $1725 for the Student Research Conf., $500 for Student Affiliates, $1000 for travel grants for undergraduates, $650 for conference assistance for high school teachers, $600 for Student Affiliate Program Sponsorships and $5600 for Connections to Chemistry partially offset by $2592 of registration fees. 17,63 Continuing Education. The $7000 in these lines may be any offsetting amounts. CE has requested that we not assume any profit. 64 Dinner and AV costs 66 Hill Award. The budget funds dinners for guests at the local award plus $1000 for the NOBCChE Hill lectureship. 69 Norris Richards Research Scholars. This budget request includes 4 scholarships at $2750 plus $500 for each of the four institutions and $700 for expenses. The Norris Trust funds all four this year. 70 Project SEED. The ACS matches student stipends which total $2275. 72 Includes hourly contracted secretarial services to Piper Enterprises (2005 total was $600). 76 Trustees. Includes $500 for secretarial services by Piper Enterprises. 77 Chair-elect. Travel and registration to leadership meetings plus $500 for networking. 78 National Chem Week. $2000 is budgeted from the Brauner Trust for an honorarium. 31,79 Summer Programs. As for continuing education, income should offset expenses but ticket prices should be increased to generate a profit. 80 ACS Scholarships. Third year of a 4 yr pledge of $2500/yr as voted in 2004. 81 Medicinal Group. The Budget committee reduced the request to last year's budget amount. 82 Travel Grants. National pays slightly less than 75% of costs up to a specified maximum. 83 Adm. Secretary to be increased from $28 to $29/hr.

72 86 Younger Chemists. The request includes $3500 for the April Research Conf. offset by $300 of fees, $6000 for a career fair, offset by $5000 of income, $300 for a Career Symposium, and $1120 for other events. 87 Jung Chemiker. $12,000 was requested as voted in the summer of 2005. The Budget Committee reduced this by $2000.

APPENDIX 2

LONG-RANGE PLAN

73

ANNUAL REPORT Northeastern Section, ACS

APPENDIX 3

MEMBERSHIP SURVEYS NEWSLETTERS

http://www.nesacs.org

74 APPENDIX 3 - MEMBERSHIP SURVEY AND 2005 NEWSLETTER

3-A: SURVEY OF NESACS MEMBERS IN ATTENDANCE AT MARCH 2005 MEETING OF NESACS NESACS Questionnaire March 10, 2005

Directions. Please answer each of the following questions as directed. 1. Which of the following describes your current position Student Professional Retired professional Academic

2. Do you currently attend NESACS meetings on a regular basis (3 or more meetings each year)? Yes (please go to Question 4) No

3. Which of the following are the most significant issues relating to why you don’t currently attend NESACS meetings: (please go to Question 5) General meeting topics Meeting locations General meeting times Cost of dinner at meetings Food at meetings Too busy Other______

4. What, if anything (select as many as are relevant), would you like to see the NESACS change about its meetings? Nothing General meeting topics Meeting locations General meeting times Cost of dinner at meetings Food at meetings Other______

5. Do you have any suggestions for future meeting topics? ______

6. Do you have any suggestions for possible meeting speakers?______

7. Would you like to be notified of upcoming events by e-mail? Yes (please provide your e-mail address:______) No

8. Would you like to be more active in the activities of the Northeast Section? Yes (please provide your name and daytime telephone number) ______No THANK YOU!!! J J J

75 Report on March Joint NESACS/YCC Meeting Survey Pam Mabrouk April 1, 2005

A. Survey Methodology Attendees registering for the Thursday March 10, 2005 Joint NESACS/YCC dinner were asked to complete a brief anonymous 8-question survey questionnaire (see Appendix A). To maximize the number of respondents completing the survey, individuals were told that if they completed the survey their names would be placed in a drawing for a copy of Dr. Fetzer’s (the dinner speaker) new book. Twenty four valid survey tools were obtained in this way.

B. Survey Results Breakdown of March Meeting Attendance Of the 24 survey respondents, 4% identified themselves as academics, 33% as professionals, 17% as retired professionals, and 46% as students.

58% of the respondents currently attend NESACS meetings on a regular basis (3 or more meetings each year). 88% of the professionals, 18% of the students, and 100% of the retired professionals identified themselves as regular attendees.

Of those respondents who indicated that they are regular meeting attendees, 50% would like to be more active in NESACS 29% indicated that there is nothing they feel NESACS needs to change about its meetings 33% would like to see meeting topics changed 21% would like to see meeting locations changed 13% would like to see the cost of dinner changed Food choices and general meeting times don’t appear to be issues for current meeting attendees.

The March meeting was a joint meeting with YCC focused on career issues. This likely accounts for the skewed meeting attendance by students, which accounted for 46% of the survey respondents. Interestingly, academics did not appear to attend this meeting.

Among those respondents who indicated that they do not currently regularly attend meetings, the majority identified themselves as students. 60% of those respondents who don’t regularly attend section meetings indicated that they are simply too busy . 60% of this same group of respondents indicated that they would like to be more active in NESACS.

Student respondents indicated that awareness of meetings and the meeting time are considerations affecting their participation. Food selection, dinner cost, and meeting locations do not appear to be significant issues affecting student attendance at section meetings.

A significant number of respondents offered suggestions for future meeting topics. These include new topics including biotechnology, biodefense, and nanotechnology, career-related, industrial chemistry, process chemistry, and physical chemistry.

Sixteen respondents (66%) indicated their desire to be notified of upcoming NESACS events via e-mail by providing their e-mail addresses (see Appendix B). The high response rate among the respondents suggests that members would be receptive to efforts to contact them about section events, etc. electronically.

76 Ten respondents (42%) indicated their interest in more active participation in the section by providing contact information (see Appendix B). The significant response rate suggests that there are members who would welcome a more active role in the section and its activities.

C. Recommendations 1. We need to identify methods with which to engage our academic and student membership, who are largely non-participating members of NESACS. Academics and students do not appear to regularly participate in NESACS meetings. Based on the lack of academic respondents, it is not possible to state the reasons for this behavior at this time. However, based on the data obtained for student respondents, the primary reasons appear to be a lack of time and a lack of communication between NESACS and student chemists studying in the greater Boston area. In this regard, we recommend that the Section compile a contact list of faculty advisors (address and e-mail) for student affiliate groups at local area colleges and universities and that we work through them to begin to compile an e-mail list of student affiliates so we can contact them via e-mail and notify them of upcoming section meetings and other opportunities for involvement in the local section. One possible way of better engaging busy individuals who may not be able to regularly attend section meetings may be to develop a more vital website and web-based section activities. NESACS submitted a proposal to the Local Sections Innovative Grant Program today in order to develop an “E-section.” Planned assessment of the “E-section” program will be an important aspect of this project and should provide information concerning our effectiveness in engaging a wider section of our currently non- participating section members.

2. The Section should consider dinner speakers who can present on new topics of current interest in chemistry. A significant number of respondents identified a wide range of topics that can generally be identified as topics of current interest, e.g., biodefense, biotechnology, nanotechnology, etc. that they would like to hear about at section meetings. This may represent an opportunity to capture the interest of a broader section of our membership. So, we recommend that the Chair-Elect, who chairs the Program Committee make every effort to identify dinner speakers who can present engagingly on these topics.

3. The Section should expand its efforts to use electronic communications to be in contact with its membership. Two-thirds of the respondents indicated their interest in receiving news of upcoming events via e-mail and freely provided their e-mail address. Consequently, we urge the section to expand its efforts to use electronic communications with the membership. The logical first step would involve developing an electronic address list of the active membership and developing and implementing plans that will allow us to manage and maintain a meaningful e-mail database.

4. The Section should make a more active effort to involve members in its activities. A significant number of respondents, both currently active and inactive members, indicated an interest in being more active in section activities. Indeed 42% of the respondents provided contact information with which the Section should now follow up. Given that folks are busy we might be wise to consider more active participation in the section through its committee structure. We recommend that a listing of opportunities for service on section committees be prepared and that this information be posted on the NESACS website so interested members can directly contact section committee chairs. This listing should be made available at section meetings. We also recommend that membership forms and a sign up list be made available at all future Section meetings for those individuals who would like to be more active in the Section.

3-B: 2005 Newsletter April 2005 issue of The Nucleus uploaded into online report.

Copies of The Nucleus may be viewed in PDF format on the NESACS web site at http://www.nesacs.org

77

ANNUAL REPORT Northeastern Section, ACS

APPENDIX 4

PUBLIC RELATIONS PLAN TALKS TO PUBLIC

http://www.nesacs.org

78 APPENDIX 4

4-A: Public Relations Plan

The following public relations activities are included in the Public Relations Plan for 2006:

‹ Provide press releases for publication in The Nucleus and area newspapers relating to all meetings of the Section ‹ Make arrangements for a photographer to be present at all meetings of the Section including

• March 2006 Richards Medal Award ° April 2006 Esselen Award ° May 2006 Education Awards ° October 2006 Hill Award & 50-Year Member Certificates ° November 2006 Norris Award

‹ Photographs will also be printed in The Nucleus and posted on our web site.

‹ Arrange for preparation, e-mailing, and posting on web site of flyers describing monthly meetings; e-mail to approximately 200 chemists, colleges, and businesses in the area approximately three weeks prior to each meeting of the Section with follow-up reminder notices approximately one week prior to each meeting.

‹ Arrange for mailing, e-mailing, and posting on web site of information about Section activities relating to high school students and teachers to all high schools in the Northeastern Section's geographical area and to individual teachers who have participated in these programs in past years. Specifically, this includes the following: ° Ashdown and Olympiad Examinations ° Richards Award for Outstanding Secondary School Teaching ° Lyman C. Newell Grants to attend NEACT summer conference ° National Chemistry Week activities ° Connections to Chemistry Program for High School Teachers ° Speakers' Bureau

‹ Arrange for information about Section activities relating to college students to be mailed and e-mailed to all colleges and universities in the Northeastern Section's geographical area and to be posted on the web site. Specifically, this includes the following: ° Norris - Richards Undergraduate Summer Research Scholarships ° Northeast Student Chemistry Research Conference (NSCRC) ° National Chemistry Week activities ° Undergraduate Research Poster Session Call for Papers (ACS) ° Undergraduate Grants-in-Aid to attend 2007 National ACS meeting ° Philip L. Levins Memorial Prize These activities are also posted on the YCC web site

‹ Arrange for information relating to Continuing Education programs offered by the Section to be mailed to ~450 individual chemists and chemical companies, e-mailed to approximately 200 chemists, published in The Nucleus and posted on the web site.

‹ All items mentioned above will be publicized in The Nucleus and posted on the web site.

‹ Press releases relating to Section activities will be written as information is provided and upon request from officers and committee chairs; these will be distributed appropriately via flyers, The Nucleus, area newspapers, Chemical & Engineering News, and area television and radio stations.

79

APPENDIX 4-B: TALKS TO PUBLIC

Date Speaker/Affiliation - Title/Topic Location

12-Jan John Zimmer / MIT MIT Inorganic Chemistry 13-Jan Richard Lawson / AstraZeneca Harvard Faculty Club Introductory Remarks / NESACS & BAGIM Joint Meeting 13-Jan Dr. Paul Clemens / Eli & Edythe Broad Inst.—Harvard & MIT Harvard Faculty Club Multidimensional Screening: Profiling Small Molecules and Cell States Using High-Throughput Screening and Multidimensional Data Analysis 26-Jan Amrit Sinha / MIT MIT Inorganic Chemistry 3-Feb Dr. Julian Adams / Infinity Pharmaceuticals, Inc. Dartmouth College Industrial Speaker 7-Feb Prof. Russell Hughes / Dartmouth College Brandeis University Selective Activation of Aliphatic Carbon-Fluorine Bonds Using Transition Metal Complexes 8-Feb Prof. Oleg Z. Ozerov / Brandeis University Univ of New Hampshire How Pincer Ligands Can Dictate Reactivity at the Metal Center 10-Feb Prof. Shana Kelley / Boston College Northeastern University Nanotechnological Approaches to Detecting Disease-related Biomolecules 8-Mar Prof. Timothy Jamison / MIT Boston College Catalytic, Stereoselective Fragment Coupling Reactions for Total Synthesis 8-Mar Prof. Lawrence T. Scott / Boston College Univ of New Hampshire Fullerenes and Carbon Nanotubes: Challenging Targets for Chemical Synthesis 14-Mar Dr. Christopher T. Walsh / Harvard Medical School Harvard University Nature’s Inventory of Biohalogenation Catalysts 21-Mar Prof. Mary J. Shultz / Tufts University Brandeis University Water, Water at Every Surface 22-Mar Prof. Barry B. Snider / Brandeis University Univ. of Mass. Lowell Organic Chemistry 24-Mar Prof. Barbara Imperiali / MIT MIT Organic Syntheses, Inc. Lectures 24-Mar Prof. T. Ross Kelly / Boston College MIT Organic Syntheses, Inc. Lectures 29-Mar Dr. Adrian Whitty / Biogen Idec, Inc. Tufts University n/a 30-Mar Prof. Paul Champion / Northeastern University Northeastern University Experimental Studies of Strucvture, Function and Coherent Oscillations in Heme Proteins 5-Apr Prof. Paul Davidovits / Boston College Tufts University Uptake of Gas Phase Species by Organic Liquids: The Strange Interactions of Gas Phase Hydrogen Halides with Octanol 5-Apr Prof. Elena Rybak-Akimova / Tufts University Univ of New Hampshire Design and Mechanistic Studies of Metal-based Receptors and Reagents Apr 7-9 Prof. Morton Z. Hoffman / Boston University Jungchemikerforum Plenary Lecture: Chemistry Education in the United States Apr 7-9 Sarah Chobot / Boston University Undergraduate Student Jungchemikerforum Electrochemical Studies of Thioredoxin and Thioredoxin Reductase – Gaining Insight into Molecular Mechanisms Affecting Oxidative Stress Apr 7-9 Pia Lopez / MIT Graduate Student Jungchemikerforum Will Neeley / MIT Graduate Student Alex Taylor / Harvard Graduate Student

80 Oral presentations at Jungchemikerforum / Germany Apr 7-9 Liz O’Day / Boston College Undergraduate Student Jungchemikerforum Rukman DeSilva / Dartmouth College Graduate Student Tim Gay / Boston University Graduate Student Ivan Korendovych / Tufts University Graduate Student Xiaoguang Lei / Boston University Graduate Student Liz Vogel / MIT Graduate Student Dan Kennedy / University of New Hampshire Graduate Student Amritanshu Sinha / MIT Graduate Student Lauren Wolf / Boston University Graduate Student Poster presentations at Jungchemikerforum / Germany Apr 7-9 Morton Hoffman / Boston University Faculty Jungchemikerforum Ruth Tanner / University of Massachusetts Lowell Faculty Mike Strem / Strem Chemicals, Inc. Amy Tapper / Peptimmune, Inc. Lauren Wolf / Boston University Graduate Student Poster Session on NESACS Educational Programs 11-Apr Prof. Amir Hoveyda / Boston College Eli Lilly Symposium/Harvard New Catalyst Systems forChallenging Problems in Enantioselective Synthesis 14-Apr Dr. Paul Vouros / Northeastern University Harvard Faculty Club Opening Remarks / Esselen Award Meeting 14-Apr Dr. Myron S. Simon / NESACS Archivist Harvard Faculty Club The Esselen Award 26-Apr Dr. Michael Strem / Strem Chemicals, Inc. Tufts University Host: Undergraduate Chapter of ACS at Tufts University 2-May Prof. Joanne Stubbe / MIT . Harvard University Ribonucleotide Reductases: Toward Harnessing Their Suicidal Tentencies to Make Therapeutics 3-May Prof. Joanne Stubbe / MIT Harvard University Polyoxoester Synthases: Towards Making Biodegradable Polymers in Biorenewable Sources 25-May Dr. Jack B. Howard / Nano-C, Inc., Westwood Boston College Synthesis of Fullerenes and Nanotubes in Flames – from Laboratory Research to Industrial Production 25-May Prof. Lawrence T. Scott / Boston College Boston College Strategies for the Rational Chemical Synthesis of Carbon Nanotubes 25-May Jenny Yang / MIT MIT Inorganic Chemistry Seminar 16-Oct Dr. Bassam Shakhashiri / University of Wisconsin-Madison Wellesley College Brauner Memorial Lecture: The Joy of Toys 17-Oct Prof. Catherine L. Drennan / MIT Harvard University From Epoxidation to Halogenation, the Diverse Reactivity of Mononuclear Iron Enzymes – A Structural Perspective 19-Oct Arthur Watterson / University of Massachusetts Lowell Burlington (MA) H.S. It’s a Small, Small World Connections to Chemistry - 2005 19-Oct John Mauch / Belmont (MA) High School Teacher Burlington (MA) H.S. Toying with Chemistry Connections to Chemistry - 2005 20-Oct Dr. John C. Amedio, Jr. / EPIX Pharmaceuticals, Cambridge Northeastern University Exploring the Analytical and Organic Chemistry Interface: The Development of MRI Imaging Pharmaceuticals 20-Oct Prof. Howard R. Mayne / University of New Hampshire Dartmouth College Exploring the Rugged Landscape – Towards Understanding and Manipulating the Properties of Mixed van der Waals Clusters 25-Oct Prof. Lizbeth Hedstrom / Brandeis University Boston College IMP Dehydrogenase and the Dynamics of Drug Selectivity 5-Nov Prof. Guilford Jones / Boston University Boston University Undergraduate Day – Opening Remarks 5-Nov Prof. Ruth Tanner / University of Massachusetts Lowell Boston University Undergraduate Day – Opening Remarks

81 5-Nov Deborah Jue / Boston University – Student Affiliates President Boston University Undergraduate Day – Opening Remarks 5-Nov Dr. Michael Gilbert / EIC Laboratories Boston University Keynote:Undergraduate Day – Electrically Releasing Adhesives Using Nanostructured Epoxies 5-Nov Prof. Nolan Flynn / Wellesley College Boston University Undergraduate Day – From Nanoscience to Biomaterials: New Avenues in Chemical Research 5-Nov Prof. Scott Schaus / Boston University Boston University Undergraduate Day – Choosing a Graduate School 5-Nov Dr. Frank Wagner / Strem Chemicals, Inc. Boston University Undergraduate Day – Preparing Your Resume 5-Nov Prof. John Porco / Boston University Boston University Undergraduate Day – Biomimetic Synthesis of Complex Molecules 5-Nov Prof. Anthony Fernandez / Merimack College Boston University Undergraduate Day – Resuscitating a Shallow-Breathing Student Affiliates Chapter 14-Nov Prof. Mary Roberts / Boston College Brandeis University Phosphatidylinositol-Specific Phospholipase C Enzymes: Connecting Interfacial Binding to Catalysis 16-Nov Prof. Krishna Kumar / Tufts University Northeastern University A New Paradigm for Protein Design and Molecular Engineering 17-Nov Prof. Paul Champion / Northeastern University Boston College Experimental Studies of Structure, Function, and Coherent Oscillations in Heme Proteins 17-Nov Prof. Morton Hoffman / Boston University Holiday Inn/Brookline The Three Guiding Principles of Teaching and Learning Norris Award Dinner Acceptance Speech 29-Nov Prof. Jebrell Glover / MIT MIT Biochemical Analysis of the Campylobacter Jejuni Pgl N-linked Glycosylation Pathway 5-Dec Prof. David Walt / Tufts University Tufts University. Array-based Biosensing: DNA to Cell Arrays 8-Dec Norton Peet / MCG Holiday Inn/Woburn Introductory Remarks / MCG Symposium – Diabetes II, Part 2 12-Dec Prof. Joanne Stubbe / MIT Brandeis University Rubibyckeitude Reductases: Something for Everyone

82

ANNUAL REPORT Northeastern Section, ACS

APPENDIX 5

AS NEEDED BY SECTION NESACS REPORTS

http://www.nesacs.org

83 NORTHEASTERN SECTION OFFICERS / COUNCILORS / CHAIRS -- 2005

Chair Dr. Amy Tapper Peptimmune, 64 Sidney St., Suite 380, Cambridge, MA 02139 (P) 617-715-8005 [email protected]

Chair-elect Dr. Patricia A. Mabrouk Department of Chemistry, Northeastern University, Boston, MA 02115 (P) 617-373-2845 (F) 617-373-8795 [email protected]

Past-Chair Dr. Jean A. Fuller-Stanley Chemistry Dept., Wellesley College, Wellesley, MA 02481 (P) 781-283-3224 (F) 781-283-3642 [email protected]

Secretary Dr. Michael Singer Sigma-RBI, 1 Strathmore Road, Natick, MA 01760 (P) 508-651-8151 x291 (F) 508-655-1359 [email protected]

Treasurer Dr. James U. Piper 19 Mill Road, Harvard, MA 01451 (P) 978-456-8622 (F) 978-456-8949 [email protected]

Auditor Dr. Anthony L. Rosner 1443 Beacon Street, Apt. No. 201, Brookline, MA 02446 (P) 703-276-7455 (F) 703-276-8178 [email protected]

Trustee Dr. Esther A. H. Hopkins 1550 Worcester Road, Unit 309, Framingham, MA 01702 (P) 508-872-8148 [email protected]

Trustee Mr. Joseph A. Lima 11 Morningside Avenue, Natick, MA 01760 (P) 617-244-5764 (F) 617-254-2713 [email protected]

Trustee Dr. Michael E. Strem Strem Chemicals, Inc., 7 Mulliken Way, Newburyport, MA 01950 (P) 978-462-3191 (F) 978-465-3104 [email protected]

Councilor Miss Mary Burgess 63 Weld Hill Street, Boston, MA 02130-4150 (P) 617-522-9165 [email protected]

Councilor Mrs. Michaeline Chen 529 Grove Street, Needham, MA 02492 (P) 781-235-5201 [email protected]

84

Councilor Dr. Catherine Costello B. U. School of Medicine, 715 Albany Street R-806, Boston, MA 02118-2394 (P) 617-638-6490 (F) 617-638-6491 [email protected]

Councilor Dr. Jean A. Fuller-Stanley Chemistry Dept., Wellesley College, Wellesley, MA 02481 (P) 781-283-3224 (F) 781-283-3642 [email protected]

Councilor Dr. Thomas Gilbert Chemistry Department, Northeastern University, Boston, MA 02115 (P) 617-373-4505 (F) 617-373-8795 [email protected]

Councilor Dr. Michael J. Hearn Chemistry Department, Wellesley College, Wellesley, MA 02481 (P) 781-283-3127 (F) 781-283-3642 [email protected]

Councilor Dr. Morton Z. Hoffman Chemistry Department, Boston University, Boston, MA 02215-2507 (P) 617-353-2494 (F) 617-353-6466 [email protected]

Councilor Dr. Doris I. Lewis 236 Lexington Street, Newton, MA 02466 (P) 617-573-8546 (F) 617-573-8668 [email protected]

Councilor Dr. Truman S. Light 85C Seminary Avenue, Lasell Village, Apt. 239, Auburndale, MA 02466-0260 (P) 617-244-5764 [email protected]

Councilor Dr. Patricia A. Mabrouk Department of Chemistry, Northeastern University, Boston, MA 02115 (P) 617-373-2845 (F) 617-373-8795 [email protected]

Councilor Dr. Julia Miwa Chemistry Dept., Wellesley College, Wellesley, MA 02481-8203 (P) 781-283-3128 (F) 781-283-3642

Councilor Dr. Dorothy J. Phillips 10 Lamplight Circle, Natick, MA 01760 (P) 508-482-2860 (F) 508-482-3100 [email protected]

Councilor Dr. Michael Singer Sigma-RBI, 1 Strathmore Road, Natick, MA 01760 (P) 508-651-8151 x291 (F) 508-655-1359 [email protected]

85 Councilor Dr. Amy Tapper Peptimmune, 64 Sidney St., Suite 380, Cambridge, MA 02139 (P) 617-715-8005 [email protected]

Alternate Councilor Dr. Timothy B. Frigo Advanced Magnetics, Inc., 61 Mooney Street, Cambridge, MA 02138 (P) 617-497-2070 (F) 617-547-2445 [email protected]

Alternate Councilor Dr. Mark Froimowitz 90 Eastbourne Road, Newton, MA 02459-1206 (P) 617-732-2851 [email protected]

Alternate Councilor Dr. Wallace J. Gleekman 35 Rangeley Road, West Newton, MA 02465 (P) 617-527-1192 [email protected]

Alternate Councilor Dr. Patrick M. Gordon 1 Brae Circle, Woburn, MA 01801-2222 (P) 781-932-0169 [email protected]

Alternate Councilor Dr. Lowell H. Hall Chem. Dept., Eastern Nazarene College, Quincy, MA 02170 (P) 617-773-6350 (F) 617-773-4839 [email protected]

Alternate Councilor Mrs. Arlene W. Light 85C Seminary Avenue, Lasell Village, Apt. 239, Auburndale, MA 02466-0260 (P) 617-244-5764 [email protected]

Alternate Councilor Dr. Mary A. Mahaney 12 Commonwealth Avenue, Dedham, MA 02026-1435 (P) 617-577-5541 [email protected]

Alternate Councilor Dr. Howard R. Mayne Department of Chemistry, University of New Hampshire, Durham, NH 03824-3598 (P) 603-862-2358 (F) 603-862-2529 [email protected]

Alternate Councilor Pamela Nagafuji 354 Broadway, #2, Cambridge, MA 02139 (H) 781-910-0625 [email protected]

Alternate Councilor Dr. Donald O. Rickter 88 Hemlock Street, Arlington, MA 02474 (P) 781-643-7575 [email protected]

86 Alternate Councilor Dr. Lawrence T. Scott Chemistry Department, Boston College, Chestnut Hill, MA 02467 (P) 617-552-8024 [email protected]

Alternate Councilor Dr. J. Donald Smith Dept. of Chem., Univ. of Mass. Dartmouth, No. Dartmouth, MA 02747 (P) 508-999-8231 (F) 508-999-9167 [email protected]

Alternate Councilor Dr. Alfred Viola 14 Glover Road, Wayland, MA 01778 (P) 508-358-7222 [email protected]

Alternate Councilor Mrs. Barbara Wood P. O. Box 198, Melvin Village, NH 03850 (H) 603-544-3351 [email protected]

Director-at-Large Vacant Dr. Henry Brown elected / deceased October 15, 2005

Director-at-Large Dr. Graham B. Jones Northeastern University, 102 Hurtig, 360 Huntington Ave., Boston, MA 02115 (P) 617-373-2822 [email protected]

Director-at-Large Dr. Ernest V. Groman 80 Columbia Street., Brookline, MA 02446 (P) 617-738-8501 [email protected]

Director-at-Large Dr. Sarah Iacobucci Chem. Dept., Tufts University, 62 Talbot Ave., Medford, MA 02155 (P) 978-453-5047 [email protected]

Director-at-Large Stephen Lantos 22 McTernan Street, Cambridge, MA 02139 (P) 617-491-3637 (F) 617-730-2635 [email protected]

Director-at-Large Dr. Gary R. Weisman Dept. of Chemistry, University of New Hampshire, Durham, NH 03824 (P) 603-862-2304 [email protected]

Archivist Dr. Myron S. Simon 20 Somerset Road, West Newton, MA 02465-2722 (P) 617-332-5273 [email protected]

87

Awards Chair Dr. Michael J. Dube Nye, Inc., P. O. Box 8927, New Bedford, MA 02742-8927 (P) 508-996-6721 (F) 508-997-5285 [email protected]

Board of Pubs. Chair Mrs. Vivian K.Walworth 215 Valley Road, Concord, MA 01742-4924 (P) 978-369-3735 [email protected]

Budget Chair Dr. James U. Piper 19 Mill Road, Harvard, MA 01451 (P) 978-456-8622 (F) 978-456-8949 [email protected]

Chem Hlth/Sfty Chair Dr. James A. Kaufman 101 Oak Street, Wellesley, MA 02482 (P) 508-624-1900 [email protected]

Chem. Ed. Chair Dr. Ruth Tanner Department of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854 (P) 978-934-3662 (F) 978-934-2013 [email protected]

Const./Bylaws Chair Dr. Catherine Costello B. U. School of Medicine, 715 Albany Street R-806, Boston, MA 02118-2394 (P) 617-638-6490 (F) 617-638-6491 [email protected]

Continuing Ed. Chair Dr. Alfred Viola 14 Glover Road, Wayland, MA 01778 (P) 508-358-7222 [email protected]

Corporate Funding Dr. Dorothy J. Phillips 10 Lamplight Circle, Natick, MA 01760 (P) 508-482-2860 (F) 508-482-3100 [email protected]

Esselen Chair Dr. Paul Vouros Chemistry Dept., Northeastern University, Boston, MA 02115 (P) 617-373-=2840 [email protected]

Local Arrangements Miss Mary Burgess 63 Weld Hill Street, Boston, MA 02130-4150 (P) 617-522-9165 [email protected]

Med. Chem. Rep. Dr. S. B. Rajur 5 Keystone Way, Andover, MA 01810 (P) 978-764-7068 [email protected]

88 Membership Chair Mrs. Michaeline Chen 529 Grove Street, Needham, MA 02492 (P) 781-235-5201 [email protected]

NCW Chair Dr. Christine Jaworek-Lopes Emmanuel College, 400 The Fenway, Boston, MA 02115 (P) 617-264-7614 [email protected]

NERM Chair Dr. Morton Z. Hoffman Chemistry Department, Boston University, Boston, MA 02215-2507 (P) 617-353-2494 (F) 617-353-6466 [email protected]

Nominations Chair Dr. Jean A. Fuller-Stanley Chemistry Dept., Wellesley College, Wellesley, MA 02481 (P) 781-283-3224 (F) 781-283-3642 [email protected]

Norris Award Chair Dr. Howard R. Mayne Department of Chemistry, University of New Hampshire, Durham, NH 03824-3598 (P) 603-862-2358 (F) 603-862-2529 [email protected]

Nucleus / Editor Dr. Michael Filosa 18 Tamarack Road, Medfield, MA 02052-1816 (P) 781-386-8479 [email protected]

Prof. Relations/ Dr. Mukund S. Chorghade Career Services 14 Carlson Circle, Natick, MA 01760 (P) 508-651-7809 (F) 508-651-7920 [email protected]

Program Chair Dr. Patricia A. Mabrouk Department of Chemistry, Northeastern University, Boston, MA 02115 (P) 617-373-2845 (F) 617-373-8795 [email protected]

Project SEED Chair Dr. Patricia A. Mabrouk Department of Chemistry, Northeastern University, Boston, MA 02115 (P) 617-373-2845 (F) 617-373-8795 [email protected]

Pub. Relations Chair Dr. Stephen A. Doherty 44 North Main Street, Newmarket, NH 03857 (P) 603-686-0813 [email protected]

Richards Medal Chair Dr. Charles E. Kolb Aerodyne Res., Inc., 45 Manning Road, Billerica, MA 01821-3976 (P) 978-663-4918 [email protected]

89 Senior Chemists Chair Mr. Charles J. Bardsley 61 Harrison Avenue, Braintree, MA 02184-4911 (P) 781-843-6604 [email protected]

Webmaster Sathish Rangarajan 110 Brainerd Rd., #3, Allston, MA 02134 [email protected]

YCC Co-Chair Lauren Wolf Chem. Dept., Boston University, Boston, MA 02215 (P) 617-353-3072 (F) 617-353-6466 [email protected]

YCC Co-Chair Ivan Korendovych Chem. Dept., Tufts University, 62 Talbot Ave., Medford, MA 02155 (P) 617-627-5745 [email protected]

NESACS CALENDAR OF ACTIVITIES - 2005

Date Activity

January 2005 Call for Nominations: Philip L. Levins Memorial Prize (Graduate Student) January 2005 Call for Nominations: Aula Laudis Society (Secondary Teachers) January 13 Monthly Meeting - Harvard Faculty Club Joint meeting with Boston Area Group for Informatics and Modeling (BAGIM) Dr. Paul Clemons, Eli & Edythe Broad Institute of Harvard and MIT Topic: Multidimensional Screening: Profiling Small Molecules and Cell States Using High-Throughput Screening and multidimensional Data Analysis January 27 Chair’s First Networking/Social Event: Harpoon Brewery Tour and Dinner at No Name Restaurant, Boston February 2005 Call for Nominations: James Flack Norris Award February 2005 Dr. Michael Filosa appointed Editor of The Nucleus February 10 Monthly Meeting - Joint Meeting with Northeastern University Student Chapter of the Materials Research Society – Northeastern University, Boston, MA Dr. Shana Kelley, Boston College Topics: “Nanotechnological Approaches to Detecting Disease-Related Biomolecules.” Note: Meeting canceled because of major storm March 2005 Call for Papers: Northeast Student Chemistry Research Conference (Graduate & Undergraduate Students) March 10 Monthly Meeting – Joint Meeting with Younger Chemists Committee - Holiday Inn, Brookline, MA Younger Chemists Committee Symposium and Networking Event: Topic: Making the Transition from School to a Career: Experiences and Advice Dr. Nora Conlon (EPA) – Government Dr. Alexander Kolchinski (Pharm-Eco) – Industry Prof. Oleg Ozerov (Brandeis University) – Academia Dinner Meeting Topic: Chemistry as a Soft Science Dr. John Fetzer, Fetzpahs Consulting March 31 Northeast Student Chemistry Career Fair – Holiday Inn, Brookline, MA ACS Career Services workshops on resume-writing and interviewing skills Job Fair

90 April 2005 Call for Nominations: Henry A. Hill Award April 15 Monthly Meeting - Harvard University Gustavus John Esselen Award Dr. Jean M. J. Frechet, University of California, Berkeley Topic: “Functional Macromolecules: From Design and Synthesis to Applications Apr. 3-10 5th Annual NESACS-NSYC/GDCh-JCF Exchange Program NESACS/YCC hosted by GDCh in Berlin, Germany April 23 Northeast Student Chemistry Research Conference – M.I.T. May 2005 Call for Applications: Lyman C. Newell Grants (Secondary Teachers) May 21 Summerthing I - Fenway Park, Boston Boston Red Sox & Atlanta Braves Baseball Game May 12 Monthly Meetng / Education Awards - Northeastern University Dr. Richard Connell, Pfizer Corporation Topic: “The Central Role of Medicinal Chemistry in Cancer Drug Discovery.” Presentation of Awards: Philip L. Levins Memorial Prize Norris/Richards Undergraduate Research Fellowships Undergraduate Grants-in-Aid Project SEED Certificates Richards Secondary Teaching Awards Aula Laudis Society - Induction of Members Ashdown Examination Prizes Simmons College Prize Phyllis A. Brauner Memorial Book Award May 19 Medicinal Chemistry Symposium Topic: New Targets for Type 2 Diabetes Speakers: Norton Peet, Aurigene Discovery Technologies, No. Andover, MA Introductory Remarks Javed Iqbal, Dr. Reddy’s Laboratories, Hyderabad India Balaglitazone, a New Partial PPAR-γ Agonist for Type-II Diabetes John Bondo Hansen, Novo Nordisk A/S, Denmark Preservation of Beta Cell Function in Diabetes by kir6.2/SUR1 Selective Openers of KATP Channels Steve Tam, Wyeth Research, Cambridge, MA Biostructure-based Development of Inhibitors of PTP1B May 25 YCC Bike Event – Minuteman Bikeway June 2005 Lyman C. Newell Grants Awarded to High School Teachers Grants to attend New England Association of Chemistry Teachers Summer Conference June 1 NESACS Elections / deadline for return of ballots June 6 1st Annual NESACS String Scramble Golf Tournament Wentworth Hills Golf & Country Club, Plainville, MA June 19 Summerthing II - Fenway Park, Boston Boston Red Sox & Pittsburgh Pirates Baseball Game June 28 Summerthing III - Fenway Park, Boston Boston Red Sox & Cleveland Indians Baseball Game July 30 Summerthing IV - Fenway Park, Boston Boston Red Sox & Minnesota Twins Baseball Game Aug 1-4 NEACT Summer Conference / Central Connecticut State University Theme: Pedagogy and the Standards Newell Grants awarded to four high school teachersby NESACS to attend NEACT Conference September 2005 Call for Nominations: Gustavus J. Esselen Award (Chemistry in the Public Interest) September 2005 Call for Nominations: 2006 Theodore William Richards Medal September 2005 Call for Applications: Grants-in-Aid (Undergraduate Students) - National Meeting / Atlanta, GA September 8 Monthly Meeting – Joint meeting with Medicinal Chemistry Group Medicinal Chemistry Group Symposium – Radisson Hotel, Woburn, MA Topic: Ion Channel Drug Discovery

91 Mark Varney, Sepracor, Inc., Moderator Topic: Introductory Remarks Nancy Barta, Pfizer Corp. Topic: The Role of a2- Calcium Channel Subunits in the Biological Activity of Pregabal Francesco Belardetti, Neuromed Topic: Discovery of Calcium Channel Blockers by Sequential Use of Fluorescence-Based Screens, Automated and Manual Patch-Clamp Valentin Gribkoff, Scion Pharmaceuticals Topic: Discovery and Characterization of Openers of Neuronal and Smooth Muscle Potassium Channels Mark Suto, Icagen Topic: Approaches to Ion Channel Modulators September 17 Summerthing V - Fenway Park, Boston Boston Red Sox & Oakland Athletics Baseball Game September 26 Andrew H. Weinberg Memorial Lecture – Dana Farber Cancer Institute, Boston, MA Stephen H. Friend, M.D., Ph.D. – Merck & Co., Inc. Topic: Reality Testing: Are We Leaving the Age of Alchemy in Oncologhy Yet? October 2005 Call for Papers: Undergraduate Research Poster Session - National Meeting / Atlanta, GA October 2005 Pre-Announcement - YCC-GHCh/JCF Exchange Trip to Germany Announcement of trip to Germany to take place March 12-19, 2006 October 2005 Annual Nucleus Buyers Guide published in Nucleus October 19 Connections to Chemistry - High School Teacher Workshop - Burlington (MA) High School Workshop Sessions: A: It’s a Small, Small World Arthur Watterson, Institute for Nano-Science & Engr. Technology, UMass Lowell B: Toying with Chemistry John Mauch, Belmont (MA) High School C: Why Don’t You Just Make All the Plastic Alike William Carroll, Occidental Chemical Corp. and ACS President D: Seeing the Unseeable: Demonstrating with Technology Walter Rohr, Eastchester (NY) High School E: Power from the Nucleus Leo Bobek, Nuclear Reactor Supervisor, UMass Lowell Dinner Speaker: William Carroll, President of the American Chemical Society and Vice President of Occidental Chemical Corp., Dallas, TX Do We Have a Future, or What? Wild Guesses What Chemical Education Will Be Like in 2015 October 20 Monthly Meeting – Northeastern University, Boston, MA Henry A. Hill Award for Outstanding Service to the Northeastern Section to Charles E. Kolb 50-Year Members of ACS presented certificates of recognition Dr. John C. Amedio, Jr., Epix Pharmaceuticals, Cambridge, MA Topic: Exploring the Analytical and Organic Chemistry Interface: The Development of MRI Imaging Pharmaceuticals October 2005 National Chemistry Week Activities October 16 Phyllis A. Brauner Memorial Lecture / Wellesley College Science Center Dr. Bassam Shakhashiri, University of Wisconsin-Madison Theme: The Joy of Toys! Hands-on Activities: Making Slime, Chromatography of Magic Markers, and other activities related to the yearly theme of toys. Toy Drive for needy children in Northeastern Section November 5 Fourteenth Annual Northeast Regional Undergraduate Day / Boston University Keynote Speaker: Dr. Michael Gilbert, EIC Laboratories Topic: Electrically Releasing Adhesives Using Nanostructured Epoxies Research Talks & Seminar Prof. Nolan Flynn, Wellesley College From Nanoscience to Biomaterials: New Avenues in Chemical Research

92 Prof. Alex Golger, Boston University Demonstrations in Chemistry to Fascinate Kids Prof. Scott Schaus, Boston University Choosing a Graduate School Resume’ Review and Graduate School Industry Fair Dr. Frank Wagner, Strem Chemicals Preparing Your Resume’ Research Talk Prof. John Porco, Boston University Biomimetic Synthesis of Complex Molecules Student Affiliates Workshop and Seminar Prof. Anthony Fernandez, Merrimack College Resuscitating a Shallow-Breathing Student Affiliates Chapter Dr. Adam Yeager, Boston University Development of chemical Libraries Using Parallel Synthesis including a tour of the B. U. Center for Chemical Methodology and Library Development November 10 Chair’s Second Social and Networking Event Beer Tasting and Dinner, Cambridge Brewing Company November 12 Fourth Annual Environmental Research Symposium / Bridgewater State College Keynote Speaker: Dr. John Titus, Department of Biological Sciences, Binghamton Univ., SUNY Environmental Change and Freshwater Ecology: From Organisms to Watersheds November 17 Monthly Meeting / Holiday Inn, Brookline, MA James Flack Norris Award Dinner & Program Prof. Morton Z. Hoffman, Boston University Topic: The Three Guiding Principles of Teaching and Learning November 17-18 ACS Short Course / Northeastern University Synthetic Organic Chemistry: Modern Methods and Strategies Paul Helquist, Prof. of Chemistry, University of Notre Dame November 18 Chemistry Education Symposium – Boston University In honor of Prof. Emeritus Morton Z. Hoffman, Norris Award Winner 2005 Speakers: Glenn Crosby, Prof. Emeritus, Washington State University John Moore, Prof. of Chemistry, University of Wisconsin and Editor, Journal of Chemical Education Jerry Bell, Senior Scientist, American Chemical Society Zafra Lerman, Distinguished Professor of Science and Public Policy, Columbia College, Chicago , Professor of Chemistry, Stanford University December 2005 Call for Nominations - Norris Award (Outstanding Achievement in the Teaching of Chemistry) December 2005 Call for Nominations - Levins Memorial Prize (Graduate Student) December 8 Monthly Meeting / Radisson Hotel, Woburn Joint Meeting with the Medicinal Chemistry Group Symposium: NEW TARGETS FOR TYPE II DIABETES (Part II) Norton Peet, North Andover, MA - Introductiory Remarks Mark Tepper, CytRxCorporation, Worcester, MA RNAi Technology Drives the Development of Molecular Medicines to Treat Obesity & Type II Diabetes G. Sridhar Prasad, Merck & Co., Inc., West Point, PA Development of DPPIV Inhibitors Using High Throughput Crystallography Subramanyah Hosahalli, Aurigene Discovery Technologies, Bangalore, India Design of DPPIV Inhibitors for the Treatment of Type 2 Diabetes Edwin B. Villhauer, Novartis Pharmaceuticals, East Hanover, NJ The story of Vildagliptin (LAF237): A DPP4 inhibitor for the treatment of type 2 diabetes.

93 REPORT OF THE ARCHIVIST - 2005 Myron S. Simon, Ph.D., Archivist

The Archives continue to be located in the basement of the library building at Regis College, Weston, MA.

The normal activities, collecting the reports of the meetings of the Board of Directors and the Board of Publications, the Treasurer’s reports, meeting flyers, photographs, etc. have continued. Several questions have been presented and resolved, most notably questions dealing with the method of voting in the Esselen Award competition.

Respectfully submitted, M. S. Simon

REPORT OF THE AWARDS COMMITTEE - 2005 Michael J. Dube, Chair

The responsibility of the Awards Committee for NESACS includes the presentation of two awards issued by the Section. These awards include the Henry A. Hill Award and the Phillip Levins Prize.

The former is awarded to a member of the Northeastern Section for meritorious service. This year the award was presented to Dr. Charles E. Kolb. This award was presented at the October local section meeting.

The Levins Prize is awarded to a graduate student demonstrating superior achievement. This year, the award was given to Elaine Ricicki from Northeastern University, under the direction of Prof. Paul Vouros.

Respectfully submitted, Michael J. Dube, Ph.D. Chair, NESACS Awards Committee

94 Hill Award Program 2005

NORTHEASTERN SECTION

of the

AMERICAN CHEMICAL SOCIETY

Presentation of the

Twenty-fifth

HENRY A. HILL MEMORIAL AWARD for Outstanding Contribution to the Northeastern Section

to

Charles E. Kolb

Thursday, October 20 Two thousand five Northeastern University Boston, Massachusetts

95 PROGRAM

Amy Tapper Chair, Northeastern Section, presiding

RECOGNITION OF FIFTY-YEAR MEMBERS

Presentation of Certificates...... Amy Tapper

THE HENRY A. HILL AWARD

Henry A. Hill Award...... Anthony Cromwell Hill

Introduction of Award Recipient...... Paul Davidovits

Presentation of the Award...... Michael E. Strem

Acceptance...... Charles E. Kolb

ADDRESS

"Exploring the Analytical and Organic Chemistry Interface: The Development of MRI Imaging Pharmaceuticals”

John C. Amedio, Jr. EPIX Pharmaceuticals Cambridge, MA

96 PRIOR RECIPIENTS of the HENRY A. HILL MEMORIAL AWARD for Outstanding Contribution to the Northeastern Section

Henry A. Hill (posthumously)...... 1980 Edward R. Atkinson ...... 1981 Robert D. Eddy ...... 1982 Arnet L. Powell (posthumously) ...... 1983 G. Richard Handrick...... 1984 Janet S. Perkins...... 1984 Phyllis A. Brauner...... 1985 Arno H. A. Heyn ...... 1986 Sr. Magdalen Julie Wallace (posthumously) ...... 1987 Esther A. H. Hopkins...... 1988 Wallace J. Gleekman ...... 1989 James U. Piper ...... 1990 Valerie Wilcox...... 1991 Ernest I. Becker ...... 1992 Arlene W. Light ...... 1993 Truman S. Light...... 1993 William O. Foye ...... 1994 Michael E. Strem ...... 1995 Alfred Viola ...... 1996 Mary T. Burgess...... 1997 Michaeline F. Chen...... 1997 David M. Howell ...... 1997 John L. Neumeyer...... 1998 Morton Z. Hoffman ...... 1999 Catherine E. Costello...... 2000 Myron S. Simon ...... 2001 Michael J. Hearn...... 2002 Doris I. Lewis ...... 2003 Donald O. Rickter...... 2004

97 This month we are honoring the memory of Henry A. Hill by giving awards in his name to one of our Section members for meritorious service to the Northeastern Section.

Who was Henry A. Hill?

Henry Hill was Chairman of our Section in 1963. He was very active in the national ACS, and served as a member of and chairman of several of its committees. His service on the Professional Relations Committee was especially notable where he drafted the Professional Employment Guidelines. He was Director of the ACS in 1971-1975, was elected President-elect and became President in 1976.

Born in St. Joseph, Missouri, he obtained a bachelor's degree from Johnson C. Smith University, then a segregated university for "colored" students as they were then called. Because of his excellent record, he was accepted at M.I.T., studying organic chemistry. He obtained the Ph.D. in 1942 working under Professor Robert C. Hockett with the highest grades of the graduate students in his class. While at M.I.T., he became acquainted with Professor James Flack Norris of whom he said:

He was the first big man I met who was more interested in my ability to learn chemistry than in the identity of my grandparents.

Not being able to obtain a position in industry because of prevailing discrimination, he and a few colleagues established a small consulting business. In 1946 he joined Dewey & Almy Co. as Research Supervisor, and in 1952 he became Vice President of National Polychemicals which was active in polymer chemistry. He obtained patents for blowing agents.

In 1961 he established his own research and consulting business, Riverside Laboratories, to be able to pursue his research interests and to allow him to participate in ACS activities.

After his untimely death in 1979, friends and colleagues in the Northeastern Section established the Henry A. Hill Award for Outstanding Service to the Northeastern Section. The first award was made posthumously to Henry A. Hill in 1980; his son, Anthony C. Hill, then a reporter for WGBH, accepted the award. Since then, twenty-four members of this Section have been thus honored and thereby honored the memory of Henry A. Hill. From an appreciation of Henry A. Hill delivered by Arno Heyn at the 1991 Hill Award meeting and based on notes of the late Larry Powell.

98 Honored Members

AMERICAN CHEMICAL SOCIETY

Members - Fifty Years

Oscar Francis Beumel Klaus Biemann Margaret G. Casper Joseph P. Flannery Earl Julian Forman Wallace J. Gleekman Clarence Lewis Grant Irwin J. Gruverman Louis Halberstadt L. Louis Hantman Richard S. Herd Dudley R. Herschbach Morton Z. Hoffman Conrad M. Jankowski Har Gobind Khorana Elspeth Eberlin Matkovich Terry W. Milligan Frank Louis Pilar Howard Saltsburg Nathaniel S. Schneider Allan Shepp Nashan J. Tikijian Joseph P. Tratnyek Sjirk Van Der Burg

99 50-Year Member Invitation to Hill Award Dinner

NORTHEASTERN SECTION AMERICAN CHEMICAL SOCIETY

ADMINISTRATIVE SECRETARY PHONE OR FAX 23 COTTAGE STREET (508) 653-6329 NATICK, MA 01760 MA AND NH ONLY E-MAIL: [email protected] (800) 872-2054

September 15, 2005

Name Street City, State ZIP

Salutation:

Congratulations on your fifty years of membership in the American Chemical Society. I would like to take this opportunity to commend you on your longevity and continued association with chemistry. This is a very important milestone and we of the Northeastern Section would like to celebrate with you.

At the October meeting of the Northeastern Section, in addition to presenting the Hill Award, we will be honoring our fifty-year members. I hope that you (and a guest) will be able to attend as guests of the Section so that we can congratulate you personally. We are also interested in learning about your career in chemistry. If you would like to do so, we would appreciate receiving a brief biographical sketch that can be added to the archives of the Northeastern Section. It can be sent to the Section office at the address or e-mail shown in the letterhead.

You should already have received a 50-year member lapel pin and a 50-year membership card that entitles you to free registration at ACS National and regional meetings. These were sent to you in March, 2005. If you have not received these, please let me know.

The meeting is on Thursday evening, October 20, at Dodge Hall, Northeastern University, Boston, MA. Additional information and further details of the program and speakers for the evening will appear in the October issue of The Nucleus. Please contact Marilou Cashman in the Section office by October 13 to make your dinner reservations. She may be reached by phone at (800) 872-2054 or by e-mail at [email protected].

Again, my congratulations and thanks for your many years of service.

Sincerely,

Amy Tapper, Chair Northeastern Section, ACS

100

October Meeting

The 863rd Meeting Northeastern Section

of the American Chemical Society

Northeastern Section

of the

American Chemical Society

EXPLORING THE ANALYTICAL AND ORGANIC CHEMISTRY INTERFACE: The Development of MRI Imaging Pharmaceuticals John C. Amedio, Jr. Senior Director, Analytical and Chemical R&D EPIX Pharmaceuticals – Cambridge, MA

Thursday – October 20th, 2005 Northeastern University 360 Huntington Avenue – Boston, MA Dodge Hall – Room 450 5:30 p.m. Social Hour (Cash bar) 6:15 p.m. Dinner 7:15 p.m. Monthly Meeting & Evening Program Presiding: Dr Amy Tapper, Chair, Northeastern Section, ACS 50-Year Members to be honored Presentation of the Henry A. Hill Award to Dr. Charles Kolb Speaker: John C. Amedio, Jr.

Dinner reservations should be made no later than noon on Thursday, October 13, 2005. Please send e-mail to [email protected] or call Marilou Cashman at (800) 872-2054. Please specify if you prefer a vegetarian meal. Reservations not canceled at least 24 hours in advance must be paid. Anyone who needs handicapped services/transportation, please call a few days in advance so that suitable arrangements can be made.

PRICES: Members: $28.00; Non-Members: $30.00; Retirees: $18.00, Students: $10.00. Pay at the door by cash or check; no credit cards and no purchase orders.

Directions

For driving directions and a map of the Northeastern University campus, go to the internet -- http://www.campusmap.neu.edu On the web site map, Dodge Hall is Building 43 Gainsborough Garage is Building 45

PUBLIC TRANSPORTATION IS STRONGLY SUGGESTED Take the Green Line E train to the Northeastern stop, or the Orange Line to the Ruggles stop. Follow signs from here. Or take the Orange Line to the Mass. Ave. stop and go up the stairs at the west end of the platform; go through the turnstile and right onto the pedestrian overpass. Then make a left at the bottom of the stairs near the Gainsborough Parking Garage. .A limited amount of parking will be allotted in the Gainsborough Parking Garage.

THE PUBLIC IS INVITED

101 AWARDS PRESENTED BY THE NORTHEASTERN SECTION, ACS

James Flack Norris Award Martin Saunders in Physical Organic Chemistry (presented at ACS National Meeting)

Gustavus John Esselen Award Dr. Jean M. J. Fréchet Univ. of California/Berkeley for Chemistry in the Public Interest

James Flack Norris Award Morton Z. Hoffman Boston University for Outstanding Achievement in the Teaching of Chemistry

Henry A. Hill Award Charles E. Kolb Aerodyne Res. Corp. for Outstanding Service to the Northeastern Section, ACS

Arno H. A. Heyn Memorial Book Award Mark Spitler Former Editor, The Nucleus Sam Kounaves Former NESACS Webmaster

Theodore William Richards Award Stephen Lantos Brookline High School for Excellence in Teaching Cathleen Little Pinkerton Academy, NH

Induction into the Aula Laudis Society Gary Liptak Laconia High School, NH Jerusha Vogel Lexington High School Marian Levinstein (ret.) Cambridge Rindge & Latin J. Darrell Campbell Brookline High School

Lyman C. Newell Grants Lorraine Kelly Hull High School to secondary teachers to James Kresel Martha’s Vineyard High School attend the NEACT Summer Conference Patricia Brandl Medford High School Ernestine Struzziero Lynnfield High School

Philip L. Levins Memorial Prize Elaine Ricicki Northeastern University

Norris-Richards Undergraduate Summer Tania Cabrera Simmons College Research Scholarships Jacqueline Tio M. I. T. William Hillmann Boston College Alison Erbeck Bridgewater State College

Undergraduate Grants-in-Aid Certificates Marcy Keddy Simmons College Alison Erbeck Bridgewater State College Ellen Sletten Stonehill College Yehuda Edo Paz Harvard College Sarah Fischer University of Mass. Lowell

Dr. Phyllis A. Brauner Memorial Book Award Maryann Racine M. I. T.

Project SEED Certificates Taiyang Chen, Student with Northeastern Univ. Mentor Seneca King, Teacher with Northeastern Univ. Mentor Ashdown Examination Awards: First Place / Simmons College Prize Jason J. Whittaker Wayland High School Second Place (tie) Seth Davidovits Andover High School Second Place (tie) Alexander Kazberouk Acton-Boxborough High School Third Place Michael W. Kaye Wayland High School

102 Fourth Place (tie) Daniel Rubin Framingham High School Fourth Place (tie) Andrew Hoy Xaverian Brothers High School

Honorable Mention - 1st-year Students David Wen Lexington High School Justin W. Chew Phillips Academy Peter Geon Kim Lexington High School Malcolm Campbell Lexington High School Joan How Belmont High School Kim Scott Wellesley High School

Honorable Mention - 2nd-year Students Elissa Leechawengwongs Phillips Andover Academy Noah Langowitz Wellesley High School Zachary Giustra Masconomet High School Pauli M. Kehayias Brookline High School Jacob Kravetz Wayland High School Matthew Pescatore Andover High School Arolyn M. Conwill Acton-Boxborough High School Benjamin Picillo Masconomet High School

NCW Poster Competition – Grades 3-4 Lori Merlo Job Lane Elem. School, Bedford NCW Poster Competition – Grades K-2 Tayla Thomes Merry Deb Nursery School, Braintree

103 REPORT OF THE PHYLLIS A. BRAUNER MEMORIAL LECTURE COMMITTEE - 2005 Doris I. Lewis, Chair

Members of the Phyllis A. Brauner Memorial Lecture Committee in 2005 were:

Inka Allen Chris Jaworek-Lopez Ruth Tanner Steven Allen Dudley Hershbach Ann Jenkins Bassam Shakhashiri Catherine Brauner Wally Gleekman Doris I. Lewis Carolyn Spodick Susan Brauner Esther A. H. Hopkins Julianna Lovell

As agreed by the Northeastern Section and the ACS, the Phyllis A. Brauner Lecture is held in the Northeastern Section’s territory in conjunction with National Chemistry Week and named in memory of Dr. Brauner. As envisioned and established by Phyllis, and presented by the Northeastern Section since 1986, the Lecture will be for the general public of all ages. The endowment goal is a $140,000 endowment fund with income supporting the lectures.

The committee met jointly with the NCW Committee in May and September; additionally subcommittees met to organize experiment preps on several days, volunteer activities , and the Brauner constitutional amendments. Activities of the Committee this year were centered around organizing the 2005 Phyllis A. Brauner Lecture. This year the lecturer was Bassam Shakhashiri, presenting chemical demonstrations with the NCW theme The Joy of Toys; the popular lecture was presented to capacity audiences in the morning and afternoon totaling over 350 visitors. Again this year the site of the lecture was Wellesley College, Phyllis’ alma mater; the date was Sunday, October 16. The beautiful campus was an ideal setting for the Lecture and for the hands-on activities for youngsters led by area college chemistry students. The Northeastern Section web site www.nesacs.org features the National Chemistry Week activities, and, under the NCW link, the web site of the Brauner Lecture (look for the Brauner Lecture logo). Activities for the day were led by over sixty undergraduate volunteers from Bridgewater State, Clark University, Emmanuel College, Suffolk University, and Tufts University along with other Northeastern Section volunteers, and are described in the National Chemistry Week report by Chair Chris Jaworek-Lopez. It is noteworthy that these successful activities were organized by Chris who also gave birth to a beautiful baby girl shortly after an organizational meeting on August 16; young Cassandra attended her first National Chemistry Week celebration with her mother in October. This year the event also featured a successful toy collection for victims of Hurricane Katrina. Hundreds of toys were boxed and shipped to the Mike Adams, theACS volunteer in Texas who distributed them in Louisiana and Texas for the ACS. Steve and Inka Allen worked with Constance Haddleton of Wellesley College to prepare the numerous solutions required for the lecture, assisted by Sarah Iacabucci, Doris Lewis, and Carolyn Spodick. Steve Allen annually distributes, collects, and analyzes the evaluation sheets that participants return in exchange for an NCW nanomole favor.

This year Susan Brauner was able to obtain for us radio advertising on WBUR, with additional radio spots added for free. For a modest fee of $320 our National Chemistry Week ad for the Brauner Lecture was featured as follows:

6:04am On Point 7:19am Only A Game 12:18pm Wait, Wait, Don't Tell Me 1:19pm Weekend America 2:19pm Weekend America 5:04pm All Things Considered 5:57pm All Things Considered (approximately another $1,000 in added value)

104

During the Saturday WBUR's morning lineup, for Adults 25-54 WBUR is tied for 3rd during On Point and ranked first during both Only A Game and Wait, Wait, Don't Tell Me - against all stations in this market.

National Chemistry Week and the Brauner Lecture were also featured in the Wellesley Townsman, the Boston Globe, and the Boston Parent’s Paper.

As of December 2005 the Brauner fund totaled $24,327 with a realized gain of $3065 from the Consolidated Trust. Additionally, $1030 in donations resided in the operating account. The Brauner portion of the Consolidated account was .

In November Doris Lewis, Esther Hopkins, and Jim Piper met to draw up amendments to the section Constitution and Bylaws as specified by the Board of Directors in the resolution that established theBrauner Fund. At the November meeting of the Board of Trustees Doris Lewis and Esther Hopkins proposed the following amendments to the Consititution and Bylaws. They were passed at the December meeting, and await review by the national ACS Constitution and Bylaws Committee:

Bylaw III Section 1. Add to list of standing committees: The Phyllis A. Brauner Memorial Committee.

Section13. It shall be the duty of the Phyllis A. Brauner Memorial Committee to honor appropriately the memory of Phyllis A. Brauner with scientific presentations and other activities designed to reach the public of all ages with positive messages about chemistry.

Constitution Article: Section 1. The Northeastern Section shall maintain a trust fund called the Phyllis A. Brauner Memorial Fund to which additions may be made by contributions, bequest, or otherwise. The principal of this fund, with all additions, may be merged with securities of other trust funds and invested in a single fund, in which event divisions into, between, or among the several Funds may be made by appropriating and setting aside specific securities or property at a fair valuation determined by the Board of Directors, which shall be final and conclusive.

Section 2. The income only of the Phyllis A. Brauner Memorial Committee Fund may be expended as authorized by the Board of Directors and only for such purposes as will appropriately help to perpetuate the memory of Phyllis A. Brauner.

Respectfully submitted, Doris I. Lewis, Chair

105 NORTHEASTERN SECTION AMERICAN CHEMICAL SOCIETY

PHYLLIS A. BRAUNER MEMORIAL LECTURE COMMITTEE

DR. DORIS I. LEWIS PHONE: (617) 573-8546 SUFFOLK UNIVERSITY FAX: (617) 573-8668 41 TEMPLE STREET [email protected] BOSTON, MA 02114

September 26, 2005

Dear Friend of the Phyllis A. Brauner Lecture,

I am writing on behalf of the Phyllis A. Brauner Lecture Committee to invite you to join us in attending and supporting this year’s Lecture. We welcome back the award-winning lecturer and chemical educator, Dr. Bassam Shakhashiri. Again this year the site of the lecture will be the Science Center at Wellesley College, Phyllis’ alma mater; the date is Sunday, October 16, with lectures at 11:00 and 2:00. The beautiful campus is a wonderful setting for the Lecture and for the hands-on activities for youngsters led by area college chemistry students from 10:00 to 2:00. If you would like to help out with the day’s activities, you’re cordially invited to do so; just contact me. You are invited as well to visit the Northeastern Section web site at www.nesacs.org to view the National Chemistry Week activities and the web site of the Brauner Lecture.

We are delighted to announce that as of the end of last year the Brauner Trust totaled over $58,000, including $25,000 generously provided by the Northeastern Section. The remainder has come in donations from numerous friends such as yourself, and support from the American Chemical Society. We continue to seek individual, corporate, and foundation support toward our goal of $150,000, and are appreciative of donations or of suggestions of appropriate sponsors. Establishing the Brauner Trust as a Northeastern Section Trust has ensured the continuation of the Phyllis A. Brauner Lecture as a lasting memorial to Phyllis, bringing the excitement of chemistry to the public of all ages. We are grateful for your support.

Sincerely yours,

Doris I. Lewis, Chair Phyllis A. Brauner Memorial Lecture Committee [email protected]

Phyllis A. Brauner Memorial Lecture Committee Inka Allen Michaelene Chen Sarah Iacobucci Katherine O’Sullivan Steven Allen Dudley Hershbach Ann Jenkins Bassam Shakhashiri Catherine Brauner Arno Heyn Doris I. Lewis Carolyn Spodick Susan Brauner Esther A. H. Hopkins Julianna Lovell Valerie Wilcox

106

NORTHEASTERN SECTION - COMMITTEE ON CONTINUING EDUCATION 2005 Annual Narrative Report

In accord with tradition in recent years, the Committee planned to schedule two events in 2004. Unfortunately the transition in the editorship of The Nucleus, following the death of Arno Hein, was such that the production schedule did not become available until after the deadline for submission of material for the March issue. As a result, it proved to be impossible to schedule a spring offering. A fall offering was arranged to be held at Northeastern University, which kindly made the required facilities available at no charge to the Section. Since 1993, when we learned that National ACS had decided to make ACS Short Courses available to local sections at tuition fees greatly reduced from the normal fee structure, currently in excess of $1000, this Committee has sponsored Short Courses under this aegis. Since our original offering in 1993 was a highly successful event, the Committee has continued to bring such courses to the Northeastern Section.

The Committee sponsored the two-day ACS Short Course: Synthetic Organic Chemistry: Modern Methods and Strategies Thursday, Nov. 17, 2005: 8:00 a.m. - 5:00 p.m. and Friday, Nov. 18, 2005: 8:30 a.m. - 5:00 p.m. Paid registration: 12. Total attendees: 15 9 ACS Members @ $500 3 Non-ACS Member @ $600 1 Unemployed ACS Member no charge 2 Lecturer’s assistants (Northeastern University Grad Students) no charge (In addition, 3 registrants were assessed the late-registration fee of $95) Instructor: Paul Helquist, Prof. of Chemistry, Notre Dame University.

In accord with National ACS policy, unemployed and retired ACS members were offered admission without charge on a space-available basis. The above fee schedule included an increment of $50 above the charges set by National ACS, calculated to offset Committee expenses on the basis of the minimum number of 10 registrants required for presentation of the course. The Section also keeps the incremental fees charged to Non-ACS members and to late registrants. Following the normal procedure, this course was advertised in The Nucleus in the two issues preceding the scheduled event (copies attached). Posters were also mailed to ca 500 employers of chemists on the list maintained by the Northeastern Section, notice of the Short Course was posted on the Section’s web site and was also sent to about 75 e-mail addresses maintained by the Section Office. Despite the absence of a spring presentation, there was a modest surplus of funds generated for the year, which will be utilized to support other Section activities.

E. Joseph Billo Vishnu C. Solan James Hall Alfred Viola, Chair Mary Mahaney

107

ACS SHORT COURSE Designed to improve the skills and marketability of practicing B.S., M.S., and Ph.D. chemists. The NESACS Committee on Continuing Education is pleased to sponsor this new National ACS Two-Day Short Course, at a registration fee less than half of that charged at National ACS Meetings.

Synthetic Organic Chemistry: Modern Methods and Strategies

This Short Course is designed for chemists concerned with any aspect of laboratory or manufacturing operations involving the preparation of organic compounds. It will be invaluable to chemists with any level of training (B.S., M.S., or Ph.D.) who need to update their knowledge of modern organic chemistry. Registrants are encouraged to bring a small set of molecular models to the course.

DATES and TIME: Thursday, Nov. 17, 2005; 8:00 a.m. – 5:00 p.m. and Friday, Nov. 18, 2005; 8:30 a.m. – 5:00 p.m. PLACE: Room 320 Curry Student Center, Northeastern University, 360 Huntington Ave., Boston, MA KEY TOPICS TO BE DISCUSSED: Basic strategy in designing syntheses of organic compounds; Key methods of synthetic organic chemistry in context of their applications to large numbers of actual syntheses; How to construct carbocyclic systems of several ring sizes; How to control stereochemistry in cyclic and acyclic systems and recent developments in asymmetric syntheses; Topics such as the synthon approach to organic synthesis, the use of protecting groups, and stereoelectronic effects; Use of enzymes and other biological techniques in synthesis. PROGRAM AGENDA: Topics will be selected from the following list, subject to time constraints and attendee interests. Introductory Concepts for Planning Syntheses: Strategy for Designing Syntheses; Synthetic Equivalency; Protecting Groups; Construction of Carbocyclic Systems.

Enantioselective Synthesis: Basic Concepts; Enantioselective Reagents and Catalysis; Biological Methods. Enolates and Enol Derivatives: Regio- and Stereoselective Enolate Formation and Alkylation; Stereoselective Aldol Condensations; Five- and Six-membered Ring-forming Reactions of Enolates.

Dialkylation and Coupling Reactions. Carbocation Reactions: Alkene Cyclization Reactions; Polycyclizations; Cyclization of Pentadienyl Cations. Radical Cyclization Reactions: Use of Azo Compounds; Use of Halides and Other Initiator Groups; Tandem Cyclizations. Carbene, Carbene Complexes and Other Carbene-like Species: Addition to Alkenes and Alkynes; Carbene Insertion Reactions.

Cycloadditions: 4+2 Cycloadditions: Diels-Alder Reaction; Intramolecular Diels-Alder Reaction; 3+2 Cycloadditions; 2+2 Cycloadditions; Higher Order Cycloadditions. Ene, Carbonylation, and Other x- Cyclization Reactions: Ene Reaction; Diene, Allene, and Alkyne Cyclizations; Electrocyclic Ring Closure of 1, 3-Dienes; Carbonylation Reactions. Alkene Synthesis: Wittig Reaction and Modifications; Peterson Reaction of Silanes; Julia Condensation of Sulfones; Use of Transition Metal Alkylidene Reagents; Alkene and Alkyne Metathesis Reactions; Additions to Alkynes. Rearrangements: Cyclopropane Derivatives; Gröb and Relayed Fragmentations; Cope and Claisen Rearrangements. Advanced Applications. INSTRUCTOR: Paul Helquist, Professor of Chemistry, University of Notre Dame, is the author of more than 80 papers and articles concerning new synthetic methods, the total synthesis of natural products, and applications of organometallic chemistry. You will benefit from Prof. Helquist’s extensive research and teaching experience. PRE-REGISTRATION REQUIRED – Registration Fees: ACS Members if received before Nov. 3…..…… $500.00; if received after Nov. 3 ……$595.00 Non-ACS Members if received before Nov. 3..… $600.00; if received after Nov. 3 ……$695.00 There will be a limited number of scholarships for unemployed ACS Members on a space-available basis. Parking Fee: about $14.00/day University cafeterias will be available for lunches.

108

For further information contact: Prof. Alfred Viola at (617) 373 2809 ______Registration form for Short Course: Synthetic Organic Chemistry: Modern Methods and Strategies. Nov. 17-18, 2005

Name: ______Business Affiliation: ______

Mailing ______Telephone: ______Address (Circle: Home or Work) ______E-mail: ______

Mail with remittance to: Prof. Alfred Viola, Chair NESACS Committee on Cont. Ed. Please make checks payable to NESACS Department of Chemistry (Sorry, we cannot accept credit cards or Northeastern University purchase orders.) Boston, MA 02115

109

REPORT OF THE COMMITTEE ON FUND-RAISING - 2005 Dorothy J. Phillips, Chair

Summary of Contributions and Fund-Raising Activities

Summarized are the activities held in NESACS to raise funds for programs.

Contributions did help with operating expenses. However, the program revenue was all offset by expenses; none of the events broke even from the point of view of program revenue.

Fund Sources Amount Contributions $12,700 Summer Program $1536( delta -$634) Program Revenue $12,566

Summer Program: Red Sox games which have contributed funds from ticket sales in previous years also lost money in 2005. Revenue from Red Sox baseball tickets (Dr. Wally Gleekman) was $1536.00 and expenses were $2170.

Contributions: $12,700

Name of Organization Amount (USD) Comments AstraZeneca 2000.00 Corporate solicitation Millipore 1000.00 Corporate solicitation Houghton Chemical 250.00 Corporate solicitation New England BioLab 500.00 Corporate solicitation Organix 500.00 Corporate solicitation Hovione 1000.00 Golf Tournament Contribution Lyophilization Services 1000.00 Golf Tournament Contribution DSM Pharma 1000.00 Golf Tournament Contribution IRIX Pharma 2500.00 Golf Tournament Contribution Peptimmune 300.00 Golf Tournament Contribution Genzyme 300.00 Golf Tournament Contribution Vertex 300.00 Golf Tournament Contribution Rhodia 500.00 Golf Tournament Contribution Teledyne 1000.00 Golf Tournament Contribution Cardinal Health 1000.00 Golf Tournament Contribution Other (individual) 50.00

Program Revenue $12,566

Organization Amount Comments Career Fair 3510.00 Sponsored by NESACS YCC Ashdown Registration 515.00 Northeastern Section Chemistry Research 225.00 Joint NESACS YCC and Conference (NSCRC) Education Golf Tournament 5706.00 Co-sponsored with Women Chemists Committee Connections to Chemistry 2610.00

110

Career Fair: Each year, the NSYCC holds a free career symposium for younger chemists in the region. The aim of this event is to provide younger chemists with information on current trends in the job market, possible careers in chemistry, resume writing, and interview skills. Career Symposium 2005, “Making the Transition from School to a Career: Experiences and Advice”, was held Thursday, March 10, 2005 At Brookline Holiday Inn, Brookline, MA.

NSCRC The Northeastern Student Chemistry Research Conference (NSCRC) is organized for students by students. It is devoted to the research of undergraduate, graduate, and post-doctoral chemistry students, providing a relaxed atmosphere for students to share their work. NSCRC 2005 was held April 23, 2005 at MIT (The Ray and Maria Stata Center) in Cambridge, MA

Connection to Chemistry 2005 The Northeastern Section of the American Chemical Society (NESACS) and the Education Committee of the Northeastern Section invited high school chemistry teachers to a program at Burlington High School (Burlington, MA) on Wednesday, October 19th, 3:30 – 8:00 PM. This program helps connect high school teachers with the numerous education resources that are available from the American Chemical Society.

Golf Tournament 1st Annual Northeastern Section ACS String Scramble Golf Tournament was held June 6, 2005 at Wentworth Hills Golf and Country Club, 27 Bow St., Plainville, MA, Coordinators: Drs. Amy Tapper, Chair 2005 and Harry Mandeville The Flyer and registration details are attached. All proceeds went to NESACS programs.

111

1st Annual Northeastern Section ACS String Scramble Golf Tournament

All proceeds from this tournament will go to support NESACS programs (http://www.nesacs.org)

This event is co-sponsored by the Women Chemists Committee

June 6, 2005 12 noon

Wentworth Hills Golf and Country Club 27 Bow St., Plainville, MA www.wentworthhillsgolf.com

112

Reserve an individual golfer or a full foursome. We will fill partial foursomes

Team leader or individual golfer

E-mail address Hdcp

Golfer 2

E-mail address Hdcp

Golfer 3

E-mail address Hdcp

Golfer 4

E-mail address Hdcp

Prior to May 1, $110 per golfer, $75 for students After May 1, $120 per golfer

Please send a check along with this form to Marilou Cashman, 23 Cottage St., Natick, MA 01760

113

Rules We will also be selling “Mole-igans” for $5. Everybody needs an extra shot once in a while. This is a best ball scramble. Each golfer will hit Buy a Mole-igan (or 2 or 3) and use them when his own drive. The team will select the ball they you really need them. Sorry only one extra shot wish to play for their second shot. All golfers will per Mole-igan per player per 18 holes. hit the next shot from this location (within one club length, no closer to the hole, no improving The Event the lie) and so on until the ball is holed. Putts must be played from the exact spot of the Your entry fee covers: chosen ball. A single score for the team will be Greens fee Cart recorded for the hole. Prizes including longest drive, closest to the pin and first, second and third place This is a string scramble. We will be selling Lunch before golf pieces of string in lengths of 1” ($1), 3” ($2), 6” Dinner buffet after golf ($3) and 12” ($5). If you leave a putt within the length of a piece of string you have purchased, A cash bar will be available before and during dinner. you may count that putt as holed (and thereby save a stroke). The catch: you must buy all of Questions? Contact Amy Tapper at your strings before you start and a string may [email protected] or Harry only be used once. You are on the honor Mandeville at system (as you should be any way since you are [email protected]. keeping your own score).

Golf Tournament – Osmium Level Donor Corporate Sponsors & Golf Gold

IRIX Aerodyne Research, Inc. Cambridge Isotope Laboratories Corporate Patrons & Golf Platinum New England BioLabs, Inc. Pfizer AstraZeneca R&D Boston Rhodia Pharma Solutions Cardinal Health Sigma-RBI DSM Teledyne ISCO Genzyme Drug Discovery & Development Hovione Donors & Golf Silver IBM Lyophilization Service of New England Consulting Resources Corp. Phasex Corporation Houghton Chemical Company Strem Chemicals, Inc. Organix, Inc. Zone Enterprises Peptimmune Vertex

114

EDUCATION COMMITTEE Submitted by Ruth Tanner, Chair 2005 Report

Education Committee Members

Ruth Tanner, Chair College Stephen Lantos High School Subcommittee Chair Edward Brush Student Affiliates Morton Hoffman ACS Scholars Thomas Gilbert High School Student Affiliate Clubs

The Education Committee supports and promotes academic program activities that showcase chemical education and young chemists at both the high school and college/university levels. Through announcements at the monthly meetings of the Section, in The Nucleus, and via mailings, information is provided to the membership in order to foster a greater interest in chemical education and to develop a responsible professional outlook toward chemistry among young scientists.

The Chair of the Education Committee, Ruth Tanner, is a chemistry faculty member at the University of Massachusetts Lowell. The Chair of the High School Subcommittee, Stephen Lantos, is a chemistry faculty member at Brookline (MA) High School. Student Affiliate Affairs are handled by Edward Brush, a chemistry faculty member at Bridgewater (MA) State College. The ACS Scholars program is coordinated by Morton Hoffman, the 2005 Chair of CHED and retired chemistry faculty member of Boston University. The pilot program for the High School Student Affiliate Clubs is being coordinated by Thomas Gilbert, chemistry faculty member and Acting Director, Chemistry and Chemical Biology, College of Arts & Sciences, at Northeastern University.

James Flack Norris/Theodore William Richards Undergraduate Summer Research Scholarships. (Edwin Jahngen, University of Massachusetts Lowell, Chair).

The Northeastern Section of the American Chemical Society (NESACS) established the James Flack Norris and Theodore William Richards Undergraduate Summer Scholarships to honor the memories of Professors Norris and Richards by promoting research interactions between undergraduate students and faculty. Research awards of $3250 were given for the summer of 2005. The student stipend is $2750 for a minimum commitment of ten weeks of full-time research work. The remaining $500 of the award goes to the research advisor to use on supplies, travel, and other items relevant to the student project.

The 2005 scholarships were awarded to: Tania Cabrera, Simmons College, Templating Calcium Oxalate Growth for in-situ Atomic Force Microcopy Studies; Prof. Richard Gurney, Advisor

Alison Erbeck, Bridgewater State College, Synthesis and Evaluation of S-glutathionyl-3-bromooxindole acetate as a Potential Trojan Horse Inhibitor of Glyoxalase II; Edward Brush, Advisor

Jacqueline Tio, Massachusetts Institute of Technology, Novel Fluorescence-based Nitric Oxide Sensors; Stephen Lippard, Advisor

William Hillman, Boston College, Structural Determination of LnmQ, a Novel Adenylation Domain, using synthetic Inhibitors; Prof. Steven Bruner, Advisor

115

Award winners were required to submit a report of their summer projects by November 2005 for publication in The Nucleus. They are also required to participate in the Northeast Student Chemistry Research Conference (NSCRC) in April 2006.

The competition was publicized through The Nucleus, the NESACS Web site, and mailings of applications and descriptive material to the chairs of the Departments of Chemistry, Biochemistry, and Chemical Engineering at colleges and universities in the Section. Applications included student transcripts, descriptions of the proposed research, and two letters of recommendation. The awards enabled the students to spend the summer of 2005 engaged in research at their home institutions.

Fourteenth Annual Northeast Regional Undergraduate Day (Coordinated by Richard Lauren and Hosted by Chemia, ACSSA at Boston University)

The 14th annual Northeast Regional Undergraduate Day sponsored by the Education Committee was held on November 5, 2005 at Boston University in conjunction with National Chemistry Week Activities. The registrants represented colleges and universities from Massachusetts, Rhode Island, Connecticut, and Vermont. The keynote address Electrically Releasing Adhesives Using Nanostructured Epoxies was given by Dr. Michael Gilbert from EIC Laboratories. Small group topics and seminars followed that included:

Group Discussions: Choosing a Graduate School (Prof. Scott Schaus, Boston University) Demonstrations in Chemistry to Fascinate Children (Prof. Alex Golger, Boston University) Resume Review (Dr. Frank Wagner, Strem Chemicals) Reviving a Shallow-Breathing SA Chapter (Prof. Anthony Fernandez, Merrimack College)

Seminars: From Nanoscience to Biometric Materials: New Avenues in Chemical Research (Prof. Nolan Flynn, Wellesley College) Biomimetic Synthesis of Complex Molecules (Prof. John Porco, Boston University) Development of Chemical Libraries Using Parallel Synthesis [Included a tour of the Boston University Center for Chemical Methodology and Library Development] (Dr. Adam Yeager, Boston University)

A graduate school and industry fair provided students with the opportunity to obtain information from representatives of universities and industries. A nominal registration fee was charged to offset the costs of refreshments, lunch and materials. The Undergraduate Day was a National Chemistry Week activity, and was sponsored by the NESACS Education Committee.

The Fourth Undergraduate Environmental Research Symposium. Sponsored by the Education Committee of the Northeastern Section ACS et al., and Coordinated by Edward Brush et al from Bridgewater (MA) State College.

The Education Committee of NESACS co-sponsored the Fourth Annual Undergraduate Environmental Research Symposium held on Saturday, November 12, 2005 at Bridgewater State College. The symposium focuses on undergraduate and graduate research projects, with a special emphasis on environmental issues of particular concern to Southeaster Massachusetts. The program featured 28 poster presentations form 57 student co- presenters. Over 75 students, faculty and mentors were in attendance. Welcoming remarks were given by Dr. Dana Mohler-Faria, President, Bridgewater State College. President Mohler-Faria spoke of the critical importance that environmental and sustainability issues play in our world today, and how important the work that the students are doing is to our society. He also thanked the mentors for their time, effort and dedication for collaborating with and training student researchers. The keynote address Environmental Change & Freshwater Ecology: From

116

Organisms to Watersheds was given by Dr. John Titus, Department of Biological Sciences, Binghamton University, State University of New York. Two poster sessions and lunch followed Dr. Titus’ talk The complete program with all presenters, titles and abstracts can be accessed at the symposium web page: http://www.bridgew.edu/Environmental/

Attendees completed an evaluation form to help the organizers improve the current format, and plan for new and expanded initiatives. An abstract has been submitted to the session on Undergraduate Research Symposia, to be presented at the ACS National Meeting in Atlanta, March 2006. The title of the presentation is: “Hosting a multidisciplinary undergraduate environmental symposium at Bridgewater State College: Administration, impact, and funding.” Funding by NESACS will be acknowledged. In addition to NESACS, financial assistance was provided by the Bridgewater State College Adrian Tinsley Program for Undergraduate Research and by the NCUR/Lancy Initiative, a program that provides resources to undergraduates who show promise of exceptional achievement.

The Northeast Student Chemistry Research Conference (VII). Sponsored by the Education Committee of the Northeastern Section ACS and the Younger Chemists Committee of the Northeastern Section

Held at Boston University on April 23, 2005, the seventh annual Research Conference brought together undergraduates, graduates students and postdoctoral fellows from the northeastern region of the country for the purpose of celebrating their accomplishments in research, and for providing a forum for the sharing of ideas and scientific understanding. The keynote address, Optical Sensor Arrays: From Molecular and Cell Biology to Artificial Olfaction given by Dr. Will Neeley of MIT.

In addition to the research poster presentations, there were 6 student presentations: 2 undergraduate student speakers and 3 graduate student speakers. The presenting students and their institutions were: Sarah Fischer, University of Massachusetts Lowell: Scope and Limitations of the Reaction of Potassium hydride with Thiones Sarah Chobot, Boston University: Characterization of Thioredoxin Systems Via Protein Film Voltammetry Sonia Taktak, Tufts Univesity: Olefin epoxidation and aromatic Hydroxylation promoted by biomimetic amino-pyridine iron complexes – effect of coordination sphere and nuclearity Christopher Gilmore, Boston College: The Synthesis of 4®-hydroxyl-L-proline-glycine Alkene Isostere Erin Prestwich, Boston College: Amino Acid promoted DNA cleavage

Following the presentations, awards were given for the outstanding speaker and outstanding poster presentations. In addition, a presentation of the Phyllis Brauner Undergraduate Book Award was made to Sarah Chobot from Boston University for her research paper given above.

Grants -in -Aid to Undergraduates (Subcommittee: Ruth Tanner, Martin Isaks)

The Education Committee awards Grants-in-Aid of $250 each to undergraduates at colleges and universities within the Northeastern Section to enable them to attend the national spring meeting of the ACS to present a paper at the Undergraduate Research Poster Session in the Division of Chemical Education. The Education Committee awarded Grants-in-Aid to six undergraduates to enable them to attend the 231st ACS National Meeting in Atlanta, Georgia to present a paper at the Undergraduate Research Poster Session in the Division of Chemical Education on Monday, March 27, 2006. Matching funds have been committed by the awardees’ institutions to support the students’ travel. The recipients are also required to participate in the Northeast Student Chemistry Research Conference (NSCRC) in April 2006.

The awardees, their research supervisors, and the titles of the papers are as follows:

Jessica DeMott, Brandeis University, (Prof. Oleg Ozerov) Hypercoordinate Main Group PNP Pincer Complexes

117

Jessica Falco, Stonehill College (Prof. Louis Liotta) The Synthesis of Vinyl Pyrrolidine and Subsequent Synthesis of Polyhydroxylated Pyrrolidines from Commercially Available Sugars

Tania Cabrera, Simmons College (Prof. Richard Gurney) Controlling the Size, Orientation, Density, and Nucleation of Calcium Oxalate Monohydrate Crystals Using Self-Assembled Monolayers

James Hummel, Stonehill College, (Prof. Louis Liotta) The Synthesis of Vinyl and Polyhydroxylated Pyrrolidines and Subsequent Purification Using High Performance Liquid Chromatography

Applications for the travel stipend are accepted from students majoring in chemistry, biochemistry, chemical engineering, or molecular biology majors who are in good standing with at least junior status, and are currently engaged in undergraduate research.

CONNECTIONS TO CHEMISTRY (Ruth Tanner, Chair) – See total program in Appendix 5-B

Program Conference Committee: Ruth Tanner, Chair, Education Committee, NESACS; University of Massachusetts Lowell Morton Hoffman, Chair-Elect, Division of Chemical Education, ACS: Boston University Susan Buta, Chair, Speakers Bureau, NESACS Steve Lantos, Chemistry Faculty, Brookline (MA) High School

Planning and Program Associates: Christine Jaworek, Chair, National Chemistry Week, NESACS; Emmanuel College Peter Nassiff, Past-Chair, NEACT; Head, Science Division, Burlington High School Arthur Fallon, Head, Media Services, Burlington High School Mark Malagodi, Computer Services, Burlington High School Cynthis Kazangian, Director of Food Service, Burlington High School Nancy Spicer, Biochemist, Sepracor, Inc. Martin Isaks, Chemistry Faculty, University of Massachusetts Lowell James Hall, Director of Freshman Laboratories, University of Massachusetts Lowell Marilou Cashman, Executive Secretary for NESACS.

On October 19, 2005 NESACS sponsored Connections to Chemistry, a unique program to connect high school chemistry teachers to the educational resources of the ACS and to the members of the Northeastern Section. This is the sixth year for the program. Hosted by Burlington (MA) High School, the program drew over 150 teachers from 81 different high schools in Massachusetts, New Hampshire, Connecticut, Rhode Island, and Maine..

The high school chemistry teachers were welcomed to the program by Ruth Tanner (University of Massachusetts Lowell), Chair of the NESACS Education Committee and Chair of the Connections to Chemistry program. The 2005 President of the ACS, Dr. William Carroll, was at the opening session to welcome the participants to the program, and to encourage them to utilize the ACS CHED resources and to consider affiliate membership in the Division of Chemical Education via the new Chemistry Teacher Connection (CTC) program. In addition to the welcome, Dr. Carroll also presented one of the workshops (noted below) for the program.

Following the opening, five simultaneous workshops were offered in two sessions to showcase the ACS resources for high school chemistry teachers and students: Toying with Chemistry, the National Chemistry Week workshop (John Mauch, Chemistry Teacher, Braintree High School), It’s a Small, Small World, a nanotechnology workshop (Arthur Watterson, Organic Chemist, Institute for NanoScience and Engineering Technology, University of Massachusetts Lowell), Seeing the Unseeable, a technology workshop for enhancing demonstrations (Walter Rohr, Chemistry Teacher, Eastchester

118

High School, NY), Why Don’t You Just Make All the Plastic Alike? (William Carroll, Polymer Chemist, Occidental Chemical Corporation), and Exploring Nuclear Energy, a workshop on nuclear power and radioactive sources ( Gilbert Brown, Nuclear Engineer, University of Massachusetts Lowell and David Barr, Seabrook Power Station).

The evening program included dinner and a keynote address Do we Have a Future, or What? Wild Guesses What Chemical Education Wil Be Like in 2015 was also given by Dr. Carroll. Following his address, several items were raffled, including subscriptions to J. Chem. Educ., affiliate memberships in CHED, ACS Chemical Education Division CD’s and software, gift certificates for Educational Innovations, and several ACS logo products. To conclude the program, participants were given a certificate awarding professional development credits, a year’s subscription to ChemMatters, and a year’s associate membership in the Northeastern Section of the ACS.

The Connections program received substantial material assistance from the ACS, and the editorial staff of the Journal of Chemical Education:

John Moore, Editor, Journal of Chemical Education Lin Morris, Assistant Editor, Journal of Chemical Education Betty Moore, Associate Editor, Journal of Chemical Education Helen Herlocker, Manager, Office of High School Science, ACS, (ChemMatters) Kevin McCue, Editor, ChemMatters, ACS

The event received material assistance from the ACS and from Ron Perkins at Educational Innovations, and publicity support from the New England Association of Chemistry Teachers, the Massachusetts Association of Science Supervisors, the Massachusetts Association of Science Teachers, Science Teachers Area Resources Swap and the New England Science Teachers

An abstract has been submitted to the session on Undergraduate Research Symposia, to be presented at the ACS National Meeting in Atlanta, March 2006. The title of the presentation is: Six years of "Connections to Chemistry" for high school chemistry teachers.

ACS SCHOLARS PROGRAM (Morton Hoffman, Chair)

ACS Scholars: 2005-2006 academic year.

This is the fifth year for the involvement of the NESACS in the ACS Scholars Program. The NESACS sponsored one student, Jullian Smith, a freshman chemical engineering major at MIT.

In the 2005-06 academic year, 24 Scholars are studying within NESACS:

HARVARD UNIVERSITY Chikezie Eseonu Mark Garro Shirley Lemus Hufstedler Melissa McCreery Geneva Trotter

MASSACHUSETTS INSTITUTE OF TECHNOLOGY Silvana Arevalo Nia Beckley Richard Burgess Yamicia Connor Hanzel Corella Ismael Gomez Doris Grillo Gonzalez Esteban Hufstedler Robert Jackson Nicholas Pearce Aline Thomas Roberto Velazquez Cherelle Walls Jillian Smith (NESACS ACS Scholar)

119

TUFTS UNIVERSITY WHEATON COLLEGE Camille Petersen Roxana Mesias

NORTHEASTERN UNIVERSITY Mark Michelman Ryan Richardson

FRANKLIN W. OLIN COLLEGE OF ENGINEERING Hector Lefbad

These Scholars are contacted by e-mail monthly from September to May, and informed of NESACS activities of interest to undergraduates. In particular, they were invited to attend the monthly meetings of the Section, and to be its guests at the social hours and dinners that preceded the invited speakers. They also were put on the mailing list to receive THE NUCLEUS.

YCC/NESACS–JCF/GDCh Exchange to Germany (Michael Strem, Strem Chemicals, Chair, Ruth Tanner, Morton Hoffman, and YCC Members.

The Younger Chemists Committee (YCC) of the Northeastern Section and the NESACS Education Committee co- sponsored an exchange of students to Germany as the guests of the Jungchemikerforum (JCF) of the Gesellschaft Deutscher Chemiker (GDCh). The visit to Berlin took place April 3-10, 2005. The group that went on the exchange included two undergraduate and 10 graduate students.

The students attended the 2005 Frühjahrssymposium (Springtime Symposium) of the JungChemikerForum (Young Chemists Committee; JCF) of the Gesellschaft Deutscher Chemiker (German Chemical Society; GDCh), April 7-9. Oral presentations at the symposium from NESACS students were made by Pia Lopez (Schrock), M.I.T. (graduate student); William Neeley (Essigmann), M.I.T. (graduate student); Alexander Taylor (Schreiber), Harvard University (graduate student); Sarah Chobot (Elliott), Boston University (undergraduate student). Poster presentations were offered by Elizabeth O'Day (Kantrowitz), Boston College (undergraduate student); Rukman De Silva (Kull), Dartmouth College (graduate student); Timothy Gay (Tullius), Boston University (graduate student); Ivan Korendovych (Rybak-Akimova), Tufts University (graduate student); Xiaoguang Lei (Porco) Boston University (graduate student); Elizabeth Vogel (Imperiali), M.I.T. (graduate student); Daniel Kennedy (Planalp), University of New Hampshire (graduate student); Amritanshu Sinha (Schrock), M.I.T. (graduate student). A poster on the NESACS educational programs was presented by Morton Hoffman (Boston University), NESACS Councilor; Ruth Tanner (University of Massachusetts Lowell), Chair of the Education Committee; Michael Strem (Strem Chemicals, Inc.), Trustee of the Permanent Fund; Amy Tapper (Peptimmune, Inc.), 2005 NESACS Chair; and Lauren Wolf.

Sarah Chobot, a graduating senior who was doing undergraduate research on the electrochemistry of thioredoxin and thioredoxin reductase with Professor Sean Elliott, was selected as the first prize winner for the best oral presentation by a jury of professors and chemical industry representatives. The award consisted of a cash award of 250 euros (~$325) and travel to the scientific conference of her choice anywhere in the world during the coming year, an accomplishment made more significant by the fact that the win marked the first time an undergraduate had received an award of any sort at this annual international graduate student conference.

Prior to the Frühjahrssymposium (Springtime Symposium) of the JungChemikerForum (Young Chemists Committee; JCF) the students visited the R&D laboratories of Schering AG, and the chemistry facilities at the Technical University of Berlin, the University of Potsdam, and the Max Planck Institute of Colloids and Interfaces, April 4-6

120

EDUCATION COMMITTEE High School Subcommittee Stephen Lantos, Subcommittee Chair

High School Subcommittee Members Stephen Lantos, Chair Peter Nassiff Avery A. Ashdown Examination Ruth Tanner Lyman C. Newell Grants David Olney Aula Laudis Society Wallace J. Gleekman Theodore William Richards Award

Avery A. Ashdown High School Chemistry Examination Contest & U.S. Chemistry Olympiad Team (Ashdown Committee: Peter Nassiff, Chair; Steve Lantos, Wally Gleekman) (Olympiad Section Coordinator: Steve Lantos)

The HS Education Committee continues to sponsor and run the annual Avery Ashdown High School Examination Contest. Since the early 1970s, the exam has increased participation to include over 35 participating schools from across the section with well over 120 students sitting for the exam each spring. Cash prizes are awarded to the top five scorers; honorable mention certificates are given to the students earning the top five scores at each of the two levels--first and second year. Peter Nassiff will continue to head the exam writing and administration of the Ashdown Exam. Top scorers from the exam are eligible to participate in the United States National Chemistry Olympiad. We hope that increased participation and awareness of these competitive chemistry exams will allow NESACS to send one of our students to the 2006 International Chemistry Olympiad, held this summer in Gyeongsan, South Korea.

This Fall, the Northeastern Section has been asked to pilot the new ACS High School Chemistry Clubs program. We're in the midst of advertising and initiating these programs within our section and look forward to a strong response from the section's high school chemistry teachers

Cash prizes are awarded to the top five scorers; honorable mention certificates are given to the students earning the top five scores at each of the two levels--first and second year.

The 2005 awardees were: Ashdown Examination Awards: First Place / Simmons College Prize Jason J. Whittaker Wayland High School Second Place (tie) Seth Davidovits Andover High School Second Place (tie) Alexander Kazberouk Acton-Boxborough High School Third Place Michael W. Kaye Wayland High School Fourth Place (tie) Daniel Rubin Framingham High School Fourth Place (tie) Andrew Hoy Xaverian Brothers High School

Honorable Mention - 1st-year Students David Wen Lexington High School Justin W. Chew Phillips Academy Peter Geon Kim Lexington High School Malcolm Campbell Lexington High School Joan How Belmont High School Kim Scott Wellesley High School

Honorable Mention - 2nd-year Students Elissa Leechawengwongs Phillips Andover Academy Noah Langowitz Wellesley High School Zachary Giustra Masconomet High School Pauli M. Kehayias Brookline High School Jacob Kravetz Wayland High School

121

Matthew Pescatore Andover High School Arolyn M. Conwill Acton-Boxborough High School Benjamin Picillo Masconomet High School

Lyman C. Newell Grants Ruth Tanner, Chair

The Lyman C. Newell Grants provide financial assistance to high school teachers in the geographical area of the Northeastern Section of the ACS to subsidize the cost of attending the annual summer conference sponsored by NEACT, the New England Association of Chemistry Teachers. The grants are administered by the Newell Grants Committee, all of whom are high school chemistry teachers. The Committee administers the grant process starting with the publicity to the awarding of the grants. The Committee coordinates its activities with the Chair of the Education Committee and the President of NEACT.

The Northeastern Section of the American Chemical Society has awarded four Lyman C. Newell Grants for the 67th Annual Summer Conference of the New England Association of Chemistry on Teaching Chemistry Using Inquiry Approaches. The grants of $225.00 each, that partially cover the cost of the conference, were awarded to:

Lorraine Kelly Hull High School James Kresel Martha’s Vineyard High School Patricia Brandl Medford High School Ernestine Struzziero Lynnfield High School

The Lyman C. Newell Grants commemorate a former chair of the Northeastern Section who was a distinguished chemist, teacher, and historian of chemistry. For many years he was chair of the Chemistry Department at Boston University. Lyman Newell served as the first president of NEACT from 1889 to 1900 and expressed a continuing interest in training chemistry students throughout his long career. His efforts are celebrated by grants that bear his name.

Aula Laudis Society (Committee: Dave Olney, Chair; Wallace J. Gleekman, Kathy Skelly, Helen O’Keefe)

The Section recognizes outstanding secondary school teachers of chemistry by naming them to the Aula Laudis Society at the Annual Education Awards Night conducted in May. In 2005, four area teachers were inducted into the Society; i.e.,

Gary Liptak Laconia High School, NH Jerusha Vogel Lexington High School Marian Levinstein (ret.) Cambridge Rindge & Latin J. Darrell Campbell Brookline High School

Theodore William Richards Award (Committee: Wallace J. Gleekman, Chair; Emily Dudek, Christopher Doona, Martin Idelson)

The Theodore William Richards Awards for Excellence in Teaching of Secondary School Chemistry were awarded to Stephen Lantos Brookline High School Cathleen Little Pinkerton Academy, NH

122

EXAMPLES OF FORMS USED IN HIGH SCHOOL AND COLLEGE MAILINGS / WEB POSTINGS

NORTHEASTERN SECTION AMERICAN CHEMICAL SOCIETY

ADMINISTRATIVE SECRETARY PHONE OR FAX 23 COTTAGE STREET (508) 653-6329 NATICK, MA 01760 MA AND NH ONLY E-MAIL: [email protected] (800) 872-2054

TO: High School Chemistry Teachers FROM: Steve Lantos, Chair, High School Education Committee DATE: February 2005

NOTE: Please refer to the website of the Northeastern Section for Ashdown Examination information and registration forms. The URL is http://www.nesacs.org

This year's Avery Ashdown High School Chemistry Examination Contest of the Northeastern Section of the American Chemical Society will take place on SATURDAY, APRIL 2, 2005, starting at 9:00 a.m. at

SIMMONS COLLEGE: 300 The Fenway, Boston, MA 02115

At Simmons, we will be using rooms in the Science Building which is directly behind the Main College Building. Free parking will be available in the college parking lot located off Avenue Louis Pasteur. Parking permits will be issued at Simmons.

Each high school in the Northeastern Section may be represented by a maximum of five (5) participants selected by their school or teachers for each exam.. (One alternate may be named on the registration form, but only five students will be tested.) Winners of cash awards in previous years are not eligible to compete for Ashdown recognition; however, they may compete to become eligible for the Olympiad Examination. Cash awards will be given to the students with the top five (5) scores. Honorable mention awards will be given to five (5) first-year and five (5) second-year students with the next highest scores. In addition, each winning student will be invited, along with his/her teacher, to be guests of the Northeastern Section at its May, 2005 dinner meeting and will be given appropriate recognition. SCORES WILL BE REPORTED TO TEACHERS VIA E- MAIL IF ADDRESSES ARE PROVIDED ON THE TEACHER REGISTRATION FORM.

Top scorers in the Ashdown Examination will be eligible to take the qualifying exam for the Unites States Chemistry Olympiad Team on April 16. PLEASE SEE THE GUIDELINES ON THE REVERSE SIDE OF THIS MEMO FOR MORE INFORMATION ABOUT THE ASHDOWN EXAMINATION AND THE INTERNATIONAL CHEMISTRY OLYMPIAD.

Please return the enclosed STUDENT and TEACHER REGISTRATION FORMS by Tuesday, March 29, 2005, to register your students for the Ashdown Exam. Each student should bring #2 pencils to the examination. Students may use programmable or graphing calculators provided the memory is erased from the programs. This will be verified by proctors before the exam.

Along with the enclosed form for registration of students, it is requested that each school send $5.00 per student ($25 maximum) in order to help defray the cost of prizes and awards. The check should be made out to NESACS - Ashdown Exam. (Please DO NOT SEND PURCHASE ORDERS.)

Please be certain that your students make careful note of the exact information about the examination since this is not an official function of the college involved and few on campus will be aware of essential details. Any questions about the details of the examination should be directed, preferably by e-mail, to: Dr. Peter Nassiff, Burlington High School, Burlington, MA 01803 – Phone 781-270-2923 - e-mail: [email protected]

Questions relating to registrations for the exam should be directed to: Marilou Cashman (508) 653-6329 or (800) 872-2054 - e-mail: [email protected]

123 2005 AVERY A. ASHDOWN EXAMINATION GUIDELINES

1. Entrants. The Ashdown Examination has traditionally divided students into two categories: first-year and second- year/AP level. In the past problems have arisen in defining those students who are taking chemistry as a second-year course but do not follow the AP curriculum and those who are taking a first-year course but do follow the AP curriculum. The Examination Committee’s goal is to test for chemical knowledge rather than to define the academic guidelines of entrants. Thus, students will be classified as first-year (first exposure to chemistry) and second-year (a second-year of chemistry), regardless of a course name, curriculum, or an individual's background. We feel this will most fairly include as many as possible in taking the examination

2. Scoring and Prizes. Five cash prizes will be given for the top scores of ALL entrants. Duplicate scores in the top five will be considered as two of the five scores. Scoring is determined by raw score. The next five scores for both first and second year will be awarded an Honorable Mention and certificate, regardless of duplicate scores. Recognition will also be given to each teacher.

3. The Exam. The examination will be 100 multiple-choice questions. No penalty will be deducted for wrong answers.

4. U. S. National Chemistry Olympiad (USNCO). Those students wishing to compete in the International Chemistry Olympiad (IChO) qualifying examination will be selected from the top scorers. Should there be a duplicate score, both entrants may be considered. Students must be U. S. Citizens by the date of the USNCO. Only two students from any school may compete.

5. Other. Students may use programmable or graphing calculators provided the memory is erased from the programs. Proctors will verify this. Within one week of the exam date, student scores will be mailed or e-mailed to the participating schools notifying teachers of the winners. A breakdown of the range of scores and high scorers will be included along with a distribution of the types of chemistry questions included on this year's examination.

No cellular telephones will be permitted in the examination room. A secure room will be set available at the test site to store phones and bookbags.

Should there be questions about the examination, please contact Dr. Peter Nassiff at (781) 270-2923 or by e-mail to [email protected]. Questions about registrations for the exam should be addressed to the Administrative Secretary by phone or fax at the Section Office (800) 872-2054 or by e-mail to [email protected]

Dates

Registration Deadline for Ashdown Examination Tuesday, March 29, 2005 The Ashdown Examination Contest Saturday, April 2 at 9:00 a.m. at Simmons College The Qualifying Olympiad Exam Saturday, April 16 at 9:00 a.m. at Simmons College. The exam will be administered only to the top scorers on the Ashdown Exam. These students will be notified by telephone within a day or two after the Ashdown Exam. NESACS Education Night Awards Dinner Thursday, May 12, 2005 at Northeastern University. (Ashdown Award prizewinners and their teachers will be honored. Note: This information may also be found on the internet at http://www.nesacs.org

Note: This information, with the Guidelines and Registration Forms, can be found on the internet at http://www.nesacs.org

124

Call for Applications – Grants-in-Aid NORTHEASTERN SECTION AMERICAN CHEMICAL SOCIETY

ADMINISTRATIVE SECRETARY PHONE OR FAX 23 COTTAGE STREET (508) 653-6329 NATICK, MA 01760 MA AND NH ONLY E-MAIL: [email protected] (800) 872-2054

September 2, 2005

To: Chairs of Departments of Chemistry, Chemical Engineering, Biochemistry & Molecular Biology (Colleges and Universities in the Northeastern Section of the American Chemical Society

From: Professor Ruth Tanner, Chair Education Committee of the Northeastern Section of the American Chemical Society

Subject: Applications for Grants-in-Aid for Undergraduate Researchers to Attend the National Meeting of the American Chemical Society, Atlanta, Georgia, March 26-30, 2006

I am pleased to announce the continuation of the Northeastern ACS Section Grants-in-Aid program to assist undergraduates to attend the spring National ACS Meeting and present a paper on their research at the Undergraduate Research Poster Session. The 231st National Meeting will be held in Atlanta, Georgia on March 26-30, 2006.

Grants-in-Aid of $250 will be awarded to each of four undergraduates who are enrolled in the Chemistry, Chemical Engineering, Biochemistry or Molecular Biology Departments in the colleges and universities within the Northeastern Section. One condition of the Grants-in-Aid is that the award must be matched, at a minimum, by the institution.

Two copies of the application form are enclosed for you to give to undergraduate researchers who may wish to apply. Please photocopy if additional forms are needed for your students. In addition, application forms may be obtained from the NESACS web site at http://www.nesacs.org. I will be happy to answer any questions you or your students and faculty might have about the Grants-in-Aid program or the application form. I can be reached at (978) 934-3662; e mail: [email protected].

Enclosed are announcements of the Grants-in-Aid program and the Undergraduate Research Poster Session for you to post and distribute in your Department. I thank you for your help in making the activities of the Section known to your students.

The deadline for receipt of completed applications for the Grants-in-Aid is October 21, 2005. Applicants will be notified of the results by e-mail on October 28, 2005. Abstracts for the Undergraduate Research Poster Session must be received by electronic transmission at the ACS National Headquarters in Washington, DC by November 7, 2005.

Completed Grants-in-Aid applications are to be sent to: Professor Ruth Tanner University of Massachusetts Lowell Chemistry Department, Olney Hall 1 University Avenue Lowell, MA 01854-5047

125

Call for Papers

Undergraduate Research Poster Session

at the

231st National Meeting of the American Chemical Society

Atlanta, Georgia March 26 – 30, 2006

The ACS invites undergraduate students to submit abstracts of their research papers for presentation at the Undergraduate Research Poster Session (URPS), which will be part of the extensive programming for undergraduates at this national meeting. Submit your abstract electronically by November 7, 2005 to . Click on the CHED division and then select the URPS site that is appropriate to the subject of your paper. Please follow the directions carefully.

For further information, contact:

LaTrease Garrison ACS Student Affiliates Program 1155 Sixteenth Street, NW Washington, DC 20036 Tel: (800) 227-5558, ext. 6166 e–mail: [email protected]

126

Call for Applications The James Flack Norris and Theodore William Richards Undergraduate Summer Research Scholarships

The Northeastern Section of the American Chemical Society (NESACS) established the James Flack Norris and Theodore William Richards Undergraduate Summer Scholarships to honor the memories of Professors Norris and Richards by promoting research interactions between undergraduate students and faculty.

Research awards of $3250 will be given for the summer of 2005. The student stipend is $2750 for a minimum commitment of ten weeks of full-time research work. The remaining $500 of the award can be spent on supplies, travel, and other items relevant to the student project.

Institutions whose student/faculty team receives a Norris/Richards Undergraduate Summer Research Scholarship are expected to contribute toward the support of the faculty members and to waive any student fees for summer research. Academic credit may be granted to the students at the discretion of the institutions.

Award winners are required to submit a report (~5-7 double-spaced pages including figures, tables, and bibliography) of their summer projects to the NESACS Education Committee by November 4, 2005 for publication in The Nucleus. They are also required to participate in the Northeast Student Chemistry Research Conference (NSCRC) in April 2006.

Eligibility: Applications will be accepted from student/faculty teams at colleges and universities within the Northeastern Section. The undergraduate student must be a chemistry, biochemistry chemical engineering, or molecular biology major in good standing, and have completed at least two full years of college-level chemistry by summer, 2005.

Application: Application forms are available on the NESACS web site at http://www.nesacs.org. Completed applications are to be submitted no later than April 9, 2005 to the Chair of the Selection Committee:

Professor Edwin Jahngen University of Massachusetts Lowell Chemistry Department, Room 520 1 University Avenue, Olney Hall Lowell, MA 01854-5047

Notification: Applicants will be notified of the results by e-mail on April 22, 2005 with written confirmation to follow.

127

Informational Letter – Summer Research Scholarships

NORTHEASTERN SECTION AMERICAN CHEMICAL SOCIETY

ADMINISTRATIVE SECRETARY PHONE OR FAX 23 COTTAGE STREET (508) 653-6329 NATICK, MA 01760 MA AND NH ONLY E-MAIL: [email protected] (800) 872-2054

Date: February 16, 2005

To: Chairpersons of Departments of Chemistry, Chemical Engineering, and Biochemistry (Colleges and Universities in the Northeastern Section of the American Chemical Society)

From: Professor Ruth Tanner (University of Massachusetts Lowell), Chair Education Committee of the Northeastern Section of the American Chemical Society

Subject: Applications for Norris/Richards 2005 Undergraduate Summer Research Scholarships

The Northeastern Section of the American Chemical Society (NESACS) established the James Flack Norris and Theodore William Richards Undergraduate Summer Scholarships to honor the memories of Professors Norris and Richards through the promotion of research interactions between undergraduate students and faculty. Research awards of $3,250 will be given for the Summer of 2005, which include a stipend to the student of $2,750 for a minimum of ten weeks of full-time research work; the remaining $500 can be spent on supplies, travel, and other items related to the student project. I am asking for your help to make sure that all those student/faculty pairs who might be interested in applying for support are informed of this program. The deadline for receipt of the completed applications (with two supporting letters) is April 9, 2005. Applicants will be notified of the results on April 22, 2005. Completed application must be submitted to the Chair of the Selection Committee: Professor Edwin Jahngen University of Massachusetts Lowell Chemistry Department, Room 520 1 University Avenue, Olney Hall Lowell, MA 01854-5047

Enclosed is an announcement of the program. I ask you to distribute and post it where students and faculty will see it. I would also appreciate your help in making sure that students who might qualify for the scholarships, but who are majors in departments not covered by this mailing, have an opportunity to obtain the information.

Institutions whose student/faculty team receives a Norris/Richards Fellowship are expected to contribute toward the support of the faculty member and to waive any student fees for summer research. Academic credit may be granted to the students at the discretion of the institutions. Award winners are required to submit a report of their summer projects by November 4, 2005, for publication in The Nucleus, and to participate in the NESACS Northeast Student Chemistry Research Conference in April 2006.

Application forms are available on the NESACS web site at http://www.nesacs.org. If you, your students, or your faculty have any questions about the program or the application, call me at (978) 934-3662, or contact Professor Edwin Jahngen, Chair of the Selection Committee at (978) 934-3693.

Thank you for helping to make this program known and for promoting undergraduate research as a vital part of chemical education.

128

Call for Nominations – Teaching Award

Northeastern Section AMERICAN CHEMICAL SOCIETY

ADMINISTRATIVE SECRETARY PHONE OR FAX 23 COTTAGE STREET (508) 653-6329 NATICK, MA 01760 MA AND NH ONLY E-MAIL: [email protected] (800) 872-2054

THEODORE WILLIAM RICHARDS AWARD FOR EXCELLENCE IN TEACHING SECONDARY SCHOOL CHEMISTRY

ANNOUNCEMENT OF AN AWARD PROGRAM February 2005

Dear Science Department:

Do you know an excellent Chemistry teacher to nominate for the 2004 Theodore William Richards Award for Excellence in Teaching Secondary School Chemistry sponsored by the Northeastern Section of the American Chemical Society? We feel that there are many outstanding and exceptional Chemistry teachers in the Northeastern Section, so please take the time to nominate one of the deserving faculty members from your school.

The prestigious Theodore William Richards Award for Excellence in Teaching Secondary School Chemistry is presented annually to a teacher who demonstrates exceptional innovation and dedication in inspiring students (majors and non-majors alike), communication in the principles of chemistry in and out of the classroom, and leadership in influencing and mentoring other chemistry teachers. Sound like someone you know or work with? Then use the attached nomination form and recognize that teacher’s talents.

Nominations by STUDENTS (current or former), COLLEAGUES, DEPARTMENT HEADS, or INDIVIDUALS who choose to self-nominate are eligible for consideration. The deserving recipient will be honored at the Education Night ceremony in May and presented with a $1,500 cash prize and Certificate of Recognition.

Thank you for your attention in bringing recognition to the talented Chemistry teachers of the Northeastern Section, and hopefully the next deserving recipient of the prestigious Theodore William Richards Award will be from your school.

Please send nomination forms by March 31, 2005 to:

Dr. Wallace J. Gleekman, Award Committee Chair 35 Rangeley Road West Newton, MA 02465 e-mail: [email protected].

Very truly yours,

Dr. Wallace J. Gleekman

This information can be found on the website of the Northeastern Section, ACS: http://www.nesacs.org

129

Sample Education Committee Items from The Nucleus 2005

Nominations Call for Philip L. Levins Memorial Prize Nominations for the Philip L. Levins Memorial Prize for outstanding performance Abstracts! by a graduate student on the 4th Annual Environmental way to a career in chemical science Research Symposium should be sent to the Executive Secretary, Bridgewater State College NESACS, 23 Cottage St. Natick, MA01760 by March 1, 2005. Saturday, November 12, 2005 The graduate student’s research Co-Sponsored by NESACS should be in the area of organic analytical Poster abstract submission is open to chemistry and may include other all undergraduate and graduate students areas of organic analytical chemistry in the Northeastern Section at http:// such as environmental analysis, biochemical www.bridgew.edu/Environmental u analysis, or polymer analysis. Nominations may be made by a faculty member, or the student may submit an application. A biographical sketch, transcripts of graduate and undergraduate grades, a description of present research activity and three references must be included. The nomination should be specific concerning the contribution the student has made to the research and publications (if any) with multiple authors. The award will be presented at the May 2005 Section Meeting. 

130

131

Grants-in-Aid Awarded to Undergraduates

The Education Committee has of S-Glutathionyl-3-Bromooxindole awarded Grants-in-Aid of $250 each to Acetic Acid as a Potential Trojan five undergraduates at colleges and Horse Inhibitor of Glyoxalase II universities within the Northeastern Ellen Sletten, Stonehill College (Prof. Section to enable them to attend the Louis Liotta) Stereospecific Synthesis ACS National Meeting in San Diego, of Polyhydroxylated Pyrrolizidines California and present a paper at the from Commercially Available Sugars Undergraduate Research Poster Session Yehuda Edo Paz, Harvard College in the Division of Chemical Education (Prof. Gregory Verdine) Determination on Monday, March 14, 2005. of the Structural Basis for HIV-1 Integrase Matching funds have been committed Substrate Recognition by their institutions to support the students’ Ryan Smith, Stonehill College (Prof. travel. The recipients are also Leon Tilley) Isotope Effects in Solvolysis required to participate in the Northeast of alpha-Trifluoromethyl Gamma- Student Chemistry Research Conference Silyl Systems (NSCRC) in April 2005. Applications for the travel stipend are The awardees, their research accepted from students majoring in supervisors, and the titles of the papers chemistry, biochemistry, chemical are as follows: engineering, or molecular biology Marcy Keddy, Simmons College (Prof. majors. They must be in good standing Richard Gurney) Sustainable Approach with at least junior status, and be currently to Conducting Polymers Using Electrophilic engaged in undergraduate Carbohydrate Reagents research.  Alison Erbeck, Bridgewater State College, (Prof. Edward Brush) Synthesis     

132

 REPORT OF THE ESSELEN AWARD COMMITTEE – 2005 Paul Vouros, Chair

The 19th Gustavus John Esselen Award for Chemistry in the Public Interest was presented on April 14, 2005 to Dr. Jean M. J. Fréchet, Rapoport Chair of Organic Chemistry, University of California, Berkeley and Head of Materials Synthesis at the Lawrence Berkeley National Laboratory. Dr. Frechet was recognized for his fundamental and mission oriented research studies leading to the design of macromolecules for catalysis, energy harvesting and conversion, therapeutic applications, separation and microfluidic media, and nanolithography.

The award reception and dinner were held at the Harvard Faculty Club with approximately 100 people in attendance. The award ceremony and recipient’s address, “Functional Macromolecules: From Design and Synthesis to Applications”, were held in the Pfizer Lecture Hall in Mallinckrodt Chemistry Building. The award recipient was introduced by Dr. Craig Hawker, Professor of Chemistry at UC Santa Barbara. The Co-nominator, Professor Karen Wooley, of the University of Washington, St. Louis, was also present. The award, consisting of a medal and a check for $5000, was presented to Dr. Fréchet by Mr. Gustavus John Esselen, III.

The members of the 2005 Award Committee were: Rudi Baum, C&E News; Joseph Billo, Boston College; Roy Gordon, Harvard University; William Klemperer, Harvard University, Robert Langer, MIT; Thomas Verhoeven, Eli Lilly, Corp.; Paul Vouros, Northeastern University

Dr. William Klemperer will succeed Paul Vouros as Chair of the Esselen Award Committee for 2006, with duties to commence after the Esselen Award events for 2005.

Submitted by, Paul Vouros, Chair Esselen Award Committee, 2005

Dr. Jean M. J. Fréchet Esselen Award Recipient 2005

133

Invitation to Esselen Award Dinner

The Board of Directors of the Northeastern Section of the American Chemical Society requests the honor of your presence on the occasion of the nineteenth presentation of The Gustavus John Esselen Award for Chemistry in the Public Interest to Jean M. J. Fréchet on Thursday, April 14, 2005

5:30 o’clock 8:15 o’clock Preprandial hour and dinner Award ceremonies Harvard Faculty Club Pfizer Lecture Hall 20 Quincy Street Mallinckrodt Chemistry Laboratories Cambridge, Massachusetts 12 Oxford Street Cambridge, Massachusetts

Black Tie Optional

134

Esselen Award Dinner Program

Presentation of the

Nineteenth

GUSTAVUS JOHN ESSELEN AWARD

for

CHEMISTRY IN THE PUBLIC INTEREST

to

JEAN M. J. FRÉCHET

Thursday, April Fourteenth Two Thousand Five Harvard University Cambridge, Massachusetts

135

JEAN M. J. FRÉCHET Rapoport Chair of Organic Chemistry University of California – Berkeley and Head of Materials Synthesis, Lawrence Berkeley National Laboratory

Jean Fréchet received his first university degree in Lyon, France in 1967. He received Ph.D. degrees from SUNY and Syracuse Universities in 1971 for his work on oligosaccharides with Professor Conrad Schuerch. He was a member of the chemistry faculty at the University of Ottawa from 1973 to 1987 and, during this time, was a Visiting Scientist at the IBM Research Laboratory in San Jose, CA. In 1987, he joined the Department of Chemistry at , first as the IBM Professor of Polymer Chemistry and later as the first holder of the Peter J. Debye Chair of Chemistry at Cornell. Professor Fréchet moved to the University of California Berkeley in 1996 where he holds the Rapoport Chair of Organic Chemistry and heads the Materials Synthesis Program at the Lawrence Berkeley National Laboratory.

Among the honors and awards he has received are honorary doctorates from the University of Ottawa and from the University of Lyon I, the Kosar Memorial Award from the Society of Imaging Science and Technology, and the IUPAC Canadian National Committee Award. Within the American Chemical Society he has received the 2001 Salute to Excellence Award, a Cope Scholar Award, the ACS Award in Polymer Chemistry, the ACS Award in Applied Polymer Science, the Cooperative Research Award in Polymer Science, and the Doolittle Award in Polymer & Engineering. Professor Fréchet has been elected to the National Academy of Sciences and the National Academy of Engineering as well as elected fellow of the AAAS, the PMSE Division of the ACS, and the American Academy of Art and Sciences.

His research at the interface of organic, biological and materials chemistry is directed towards functional polymers, their design, synthesis, and applications. His work includes both fundamental and mission- oriented studies with targets such as the control of macromolecular architecture, the establishment of structure-activity relationships, the design of macromolecules for catalysis, energy harvesting and conversion, therapeutic applications, separation and microfluidic media, and nanolithography. At the University of Ottawa in 1973 he started a research program aimed at the development of functional polymers as reagents and supports for solid-phase syntheses. These synthetic approaches became widely used nearly two decades later with the advent of combinatorial chemistry. The concept of chemical amplification used today for the microlithographic fabrication of nearly all state-of-the-art microelectronic devices emerged from his 1979 work in collaboration with C. G. Willson of the IBM Research Laboratory on functional polymers as photoresists. His approach to precise biocompatible dendritic carriers for the targeted delivery of anticancer drugs has been licensed and is under consideration for commercial development.

136

GUSTAVUS JOHN ESSELEN 1888-1952

Born in Roxbury, Massachusetts, Gustavus J. Esselen received his higher education at Harvard, where he was awarded the A.B. (magna cum laude) in chemistry in 1909 and the doctorate in 1912. In that same year he married Henrietta W. Locke, a chemistry graduate at Radcliffe. Their three children are Mrs. Bradford K. Bachrach, Mrs. George B. Hanson and Gustavus John III.

His professional career was devoted to chemical research, first with General Electric Co. in Lynn, Arthur D. Little, Inc. in Cambridge, and Skinner, Sherman and Esselen, in Boston. In 1930 he founded Gustavus J. Esselen, Inc., later known as Esselen Research Corporation. Over the years he successfully solved a variety of problems for industrial clients in such fields as plastics, synthetic fibers, paper, rubber, and glass. Among these was the development of anhydride curing agents for epoxy resins and polyvinyl butyral as an improved material for safety glass, both of which enjoyed considerable commercial success. More than 40 U.S. patents were issued as a result of his research efforts.

Esselen was an active member of the American Chemical Society for 43 years. He served two terms as chairman of the Northeastern Section (1922 and 1923) and was Councilor and Director at the National level. In 1948 he received the James Flack Norris Honor Scroll as "the person who has done most to advance the interests of the Northeastern Section."

He was the recipient of The Modern Pioneer Award from the National Association of Manufacturers in 1940, and in 1950 he was made an honorary member of the American Institute of Chemists in recognition of his services to the professions of chemistry and chemical engineering. He was Chairman of the American Section of The Society of the Chemical Industry of Great Britain, President of the American Council of Commercial Laboratories, Director of the Boston Chamber of Commerce and President of the Rotary Club of Boston.

Esselen's distinguished contributions to chemistry and chemical engineering were in accordance with the highest ethics of these professions; his recognition of the duties of a professional led to his exertion of a wise and beneficent influence on all the professional societies to which he gave so generously of his time and led to his active participation in church and civic activities in the Boston area.

Esselen was a very sensitive person, devoted throughout his life to the fine arts and music. His motto, contained on a tapestry in his office, was a quotation of Richard Wilstatter, "It is our destiny, not to create, but to unveil."

137

Program

Preprandial Hour and Dinner Harvard Faculty Club

Esselen Award Ceremonies Pfizer Lecture Hall Mallinckrodt Chemistry Laboratories

Chair, Northeastern Section Amy Tapper Welcome Paul Vouros The Esselen Award Myron S. Simon Introduction of Jean Fréchet Craig J. Hawker Presentation of the Award Gustavus J. Esselen, III Esselen Award Address Jean M. J. Fréchet

“Functional Macromolecules: From Design and Synthesis to Applications”

The Esselen Award is made possible through an endowment by the Esselen Family in memory of Dr. Gustavus J. Esselen

138

PRIOR RECIPIENTS OF THE ESSELEN AWARD FOR CHEMISTRY IN THE PUBLIC INTEREST

F. Sherwood Rowland and Mario J. Molina ...... 1987 Discovery of the effect of chlorofluorocarbons on the ozone layer.

Alfred P. Wolf and Joanna S. Fowler ...... 1988 Chemical methods used in positron emission tomography for medical diagnostics.

Carl Djerassi ...... 1989 Contraception and the synthesis of the first birth control drug.

Thomas J. Dougherty ...... 1990 Photodynamic therapy for treatment of malignant disease.

Jerrold Meinwald and Thomas Eisner ...... 1991 Insect Chemistry and Human Welfare

Bruce N. Ames ...... 1992 Understanding the Causes of Aging and Cancer

James G. Anderson ...... 1993 Global Ozone Loss and its Prediction

Kary B. Mullis ...... 1994 The Polymerase Chain Reaction

Howard J. Schaeffer ...... 1995 Nucleosides with Antiviral Activity; Discovery of Acyclovir (Zovirax®)

Roy G. Gordon ...... 1996 Low-Emissivity Glass; Energy Conserving Windows

Rangaswamy Srinivasan ...... 1997 Ablative Photo Decomposition for Micromachining of Polymers and Biological Tissue

Kyriacos C. Nicolaou ...... 1998 Chemical Synthesis and Chemical Biology of Natural Substances

Robert S. Langer ...... 1999 The Development of Unique Polymers for Medical Applications

William A. Pryor ...... 2000 Vitamin E and the Prevention of Heart Disease

Joseph M. DeSimone ...... 2001 Green Chemistry for Sustainable Economic Development

Ronald Breslow ...... 2002 Chemistry Lessons from Biology and vice versa

Bruce D. Roth ...... 2003 The Discovery and Development of Lipitor®

James W. Jorgenson...... 2004 The Magic of Capillaries in Chemical Separations and Analysis

139

ESSELEN AWARD NIGHT

(Left to Right) Dr. Craig J. Hawker, formerly of IBM and currently with the University of California at Santa Barbara, who nominated Dr. Fréchet for the Esselen Award and introduced him at the award meeting, visits with Amy Tapper, NESACS chair, Dr. Jean M. J. Fréchet, and Paul Vouros at the reception.

Dr. Fréchet (2nd from left) was able to visit with several former students at the meeting: (3rd from left) Prof. Robert “Barney” Grubbs of Dartmouth and (4th from left) Prof. Kate Aubrecht of Holy Cross. To the far left is Prof. Karen Wooley (Washington University in St. Louis) and, to the far right, Dr. Craig Hawker, co-nominators of Dr. Fréchet for the award.

On the left, Dr. Jean M. J. Fréchet, Rapaport Chair of Organic Chemistry, University of California at Berkeley and Head of Materials Synthesis at the Lawrence-Berkeley National Laboratory, the 2005 Esselen Awardee for his work with dendrimers, visits with Myron Simon, founding member of the Esselen Committee, who spoke in regard to the emphasis of the Award for the public recognition of chemistry.

140

On the left, Dr. Jean M. J. Fréchet is presented the 2005 Esselen Award by Gustavus J. Esselen III, representing the Esselen family. Sixteen family members attended the award evening, continuing their support and interest in the award.

141

142

NOMINATIONS SOUGHT GUSTAVUS JOHN ESSELEN AWARD FOR CHEMISTRY IN THE PUBLIC INTEREST

The Esselen Award for Chemistry in the public interest is one of the most prestigious honors provided by the Northeastern Section of the American Chemical Society. The award annually recognizes a chemist whose scientific and technical work has contributed to the public well-being, and has thereby communicated positive values of the chemical profession. The Awardee should be a living resident of the United States or Canada at the time of nomination, and the significance of this work should have become apparent within the five years preceding nomination.

The Esselen Award has no limitations with respect to the chemical field in which the nominees are active. Since its inception, the award has been given to the following chemists (see over for subjects):

1987: F. Sherwood Rowland 1996: Roy G. Gordon Mario J. Molina 1997: Rangaswamy Srinivasan 1988: Alfred P. Wolf Joanna S. Fowler 1998: Kyriacos C. Nicolaou

1989: 1999: Robert S. Langer

1990: Thomas J. Dougherty 2000: William A. Pryor

1991: Jerrold Meinwald 2001: Joseph M. DeSimone Thomas Eisner 2002: Ronald Breslow 1992: Bruce N. Ames 2003: Bruce D. Roth 1993: James G. Anderson 2004: James W. Jorgenson 1994: Kary B. Mullis

1995: Howard J. Schaeffer

THE AWARD CONSISTS OF A MEDAL AND A CHECK FOR $5,000. Travel expenses incidental to the conferring of this award will be reimbursed. The award will usually be held in Cambridge, Massachusetts at the April meeting of the Northeastern Section. The Awardee will deliver an address on the subject of the work for which the honor is being conferred, or for work in progress which is also directed to chemistry in the public interest.

TO NOMINATE a candidate please provide statements from two co-sponsors as well as a brief biography of the candidate, a description of the work which has been recognized as communicating the positive values of the chemistry profession, and copies of selected, pertinent articles. Popular news and feature articles should be included as an indication of public interest. Nominations and inquiries should be directed to Dr. Paul Vouros, c/o Karen Piper, 19 Mill Road, Harvard, MA 01451. NOMINATIONS SHOULD BE POSTED NO LATER THAN OCTOBER 15, 2004. Joint nominations are acceptable. The Committee will review the nominations and the award recipient will be notified by the first of February. PAST AWARDEES AND TITLES OF AWARD ADDRESSES

143

1987: F. Sherwood Rowland, University of California at Irvine, and Mario J. Molina, now at the Massachusetts Institute of Technology. Discovery of the Influence of Chlorofluorocarbons on the Ozone Layer.

1988: Alfred P. Wolf and Joanna S. Fowler, Brookhaven National Laboratories, Chemical Procedures to Make Positron Emission Tomography a Practical Method in Medical Diagnosis.

1989: Carl Djerassi, Stanford University. Synthesis and Promotion of the First and Most Common Birth Control Hormone.

1990: Thomas J. Dougherty, Roswell Park Cancer Institute. The Development of Photodynamic Therapy for the Treatment of Malignant Disease.

1991: Jerrold Meinwald and Thomas Eisner, Cornell University. Chemical Responses in the Insect and Plant World.

1992: Bruce N. Ames, University of California at Berkeley. Methods for Detection of Carcinogens and Causes of Aging and Cancer.

1993: James G. Anderson, Harvard University. Experimental Methods for Measuring Global Ozone Loss.

1994: Kary B. Mullis. The Discovery of Polymerase Chain Reactions (PCR) for the Replication of DNA Molecules.

1995: Howard J. Schaeffer, Burroughs Wellcome Company. Nucleosides with Antiviral Activity - The Discovery of Acyclovir (Zovirax®).

1996: Roy G. Gordon, Harvard University, Low Emissivity Glass; Energy Conserving Windows.

1997: Rangaswamy Srinivasan, UVTech Associates, The Widely Used Laser Methodology of Tiny Focused Ablative Photodecomposition.

1998: Kyriacos C. Nicolaou, Scripps Research Institute, Chemical Synthesis and Chemical Biology of Natural Substances.

1999: Robert S. Langer, Massachusetts Institute of Technology, The Development of Unique Polymers for Medical Applications.

2000: William A. Pryor, Louisiana State University, Vitamin E and the Prevention of Heart Disease.

2001: Joseph M. DeSimone, University of North Carolina and North Carolina State University, Green Chemistry for Sustainable Economic Development.

2002: Ronald Breslow, Columbia University, Chemistry Lessons from Biology and vice versa.

2003: Bruce D. Roth, Pfizer Global Research & Development, The Discovery and Development of Lipitor® (Atorvastatin Calcium).

2004: James W. Jorgenson, University of North Carolina, The Magic of Capillaries in Chemical Separations and Analysis.

144

REPORT OF THE GOVERNMENT RELATIONS COMMITTEE - 2005 Doris I. Lewis, Chair

Members: Michael Hearn, Tim Rose, Michael Strem, Doris Lewis, Peter Jacobi

Our Section has four active participants in the ACS Joint Board-Council Committee on Chemistry and Public Affairs. Dr. Michael J. Hearn is a committee member and is Chair of the Grassroots Advocacy and Membership Subcommittee. Timothy L. Rose serves on the Awards Subcommittee, and was active in its continuing nomination of Stephen Lippard for the National Medal of Science which Dr, Lippard received recently. He attended the fall meeting of the committee in Washington, where the major action was joining the other scientific societies in protesting the actions of Rep. Barton in intimidating those scientists with evidence of global warming. Peter Jacobi and Doris Lewis are committee members. All are members of the Legislative Action Network which send letters to Congress in support of ACS positions, as are many other members of the Northeastern Section. Additionally, Mike Strem has been active in contacting his congressman, Rep. Tierney.

Dr. Jacobi and Dr. Lewis attended the CCPA meeting and the 4th annual ACS Legislative Summit in April, making several congressional visits. Their photos are available at http://www.chemistry.org/portal/resources/ACS/ACSContent/government/capitolconnection/2005_leg_su mmit_photos.pdf

According to recent reports the United States is facing more and more competition from new centers of innovation. If the U.S. is to maintain its competitive innovation advantage there must be a strong investment in basic research. This is the message ACS delegates delivered to Capitol Hill during the Society’s fourth annual Legislative Summit on April 6. They asked members of Congress to sustain United States innovation leadership by boosting funding levels for the Department of Energy’s Office of Science and the National Science Foundation. In preparation for the summit, participants attended a series of briefings by prominent members of the Washington science policy community: David Stonner, head, Congressional Affairs Section, National Science Foundation; Carolyn Hanna, founder and president, Secure Horizons Consulting; and James Turner, chief democratic Counsel, U.S. House of Representatives’ Committee on Science. The next morning, ACS held a breakfast with Dr. Ray Orbach, director, DOE Office of Science, who discussed new science being done by the Office of Science, the Office’s budget situation, and the need for scientists to make their voices heard on Capitol Hill.

ACS President Bill Carroll, President-elect Ann Nalley, and Past-president Chuck Casey were among the delegation who fanned out across the Hill to meet with their respective members of Congress. At each meeting they related personal experiences with NSF and the Office of Science and the importance of these agencies to the chemistry community. By the end of the day the delegation had delivered their message to over 55 congressional offices.

Overall, most members of Congress and their staff were receptive to the ACS message, and the summit proved to be a great success.

Support for Science education has been another focus of ACS legislative interest in this tight budget climate, As the Congressional budget and appropriations process unfolded, the science community has been working with allies in Congress to ensure that House and Senate appropriators get the message that the Math and Science Partnership (MSP) programs at the Department of Education (DoEd) and National Science Foundation (NSF) receive full funding if the U.S. is to maintain its position as a global technology leader.

145

ACS members across the country are playing an instrumental role in demonstrating support for the MSP programs by sending more than 2,300 letters of support to members of Congress in response to a recent Legislative Action Network alert, among them members of our Government Relations Committee as well as other Section members. We gratefully acknowledge the OLGA Capitol Connection newsletter for photos and other information in this report. Respectfully submitted, Doris Lewis

Dear NESACS Board member,

As chair of the Government Relations Committee I am forwarding this message to you as an excellent example of the Legislative Action Network in action. I know that many of you are already participants, but thought it would be worthwhile to send this message as an example of LAN alerts. Only a few such LAN messages are sent annually so as not to be intrusive, and the issues are carefully chosen by skilled ACS staff to be important, timely, and likely to be affected by our messages. If you are already an active LAN member, thank you for your participation in this important ACS activity. If you have not been participating, I invite you to join, and, if you agree with this effort to advance science education, to join in this efficient and effective way to make your voice heard in government.

Sincerely,

Doris Lewis

-----Original Message----- From: Legislative Action Network [mailto:[email protected]] Sent: Thursday, October 20, 2005 4:11 PM To: [email protected] Subject: American Chemical Society Legislative Action Alert - Science and Math Education

146

Dear LAN Member,

While the final version of the fiscal year 2006 (FY 2006) budget is currently being debated by Congress, work on the FY 2007 budget has already begun in the White House Office of Management and Budget (OMB). Now is a good time to influence next year's federal budget priorities by writing to OMB Director Joshua Bolton about the importance of science education programs at the National Science Foundation (NSF).

NSF's Education and Human Resources Directorate has witnessed drastic funding cuts since 2003--the Math and Science Partnership program was cut more than 50 percent. In addition, funding for new, competitive partnerships during the past two years has been eliminated at NSF. With your help, we can reverse this funding trend so our country can respond to the growing threats to our global competitiveness.

The budget process for fiscal year 2007 is just beginning, so we can make a huge difference by speaking up now. We urge you write to OMB Director Bolton to encourage him to expand the Math and Science Partnership program and other NSF education programs. Please link to http://www.chemistry.org/government/lac and click on "Take Action Here" under the heading Support Math and Science Education. Thank you for your help in this critical effort.

147

REPORT OF THE LOCAL ARRANGEMENTS COMMITTEE - 2005 Mary Burgess, Chair

The following is data for the meetings held during 2005 Date Location No. Attending Program / Speaker Notes January 13, 2005 Harvard Faculty Club 90 people Dr. Paul Clemens / BAGIM Joint with BAGIM

January 27, 2005 Brewery Tour / Dinner Networking/Social February 10, 2005 Northeastern University Prof. Shana Kelley / Boston College Cancelled / Storm 80 registered March 10, 2005 Holiday Inn/Brookline 50 people YCC Career Symposium Joint with YCC April 14, 2005 Harvard Faculty Club 110 people Dr. Jean Frechet / Esselen Awardee Esselen Award May 12, 2005 Northeastern University 125 people Dr. Richard Connell / Pfizer Corp. Education Awards May 19, 2005 Holiday Inn/Woburn 30 people MCG: Type II Diabetes (Pt. I) MCG Symposium June 1, 2005 Bikeway Ride Networking/Social June 6, 2005 Golf Tournament Networking/Social September 8, 2005 Cambridge Marriott 130 people MCG: Ion Channel Drug Discovery Joint with MCG October 20, 2005 Northeastern University 75 people Hill Awd/50-yr. Members Dr. John Amedio, EPIX November 17, 2005 Holiday Inn/Brookline 115 people Dr. Morton Z. Hoffman, Boston Univ. Norris Award December 8, 2005 Holiday Inn/Woburn 50 people MCG: Type II Diabetes (Pt. II) Joint with MCG

MEDICINAL CHEMISTRY GROUP Dr. Raj (SB) Rajur, Program Chair, Medicinal Chemistry Group

The first symposium of medicinal chemistry division for the year 2005 was held on May 19, 2005 at the Radisson Hotel in Woburn MA. The symposium topic was NEW TARGETS FOR TYPE 2 DIABETES. The meeting started with the welcome speech from the program chair Dr. Rajur.

Dr. Norton Peet introduced the speakers. Dr. Javed Iqbal, Dr. Reddy’s Laboratories, Hyderabad India, spoke on new partial PPAR- Agonist (Balaglitazone) for the treatment of Type-II Diabetes. Dr. John Bondo Hansen of Novo Nordisk A/S, Denmark, spoke on Preservation of Beta Cell Function in Diabetes by kir6.2/SUR1 (Openers of KATP Channels). The keynote speaker for the symposium was Dr. Steve Tam of Wyeth Research, Cambridge, MA. Dr. Tam’s talk was focused on Biostructure-based Development of PTP1B Inhibitors.

The meeting was well attended and there were about 110 participants present at this symposium.

The second symposium was held on September 8, 2005 Cambridge Marriott Hotel. The topic was “ION CHANNEL DRUG DISCOVERY”. Dr. Mark Varney, VP of Drug Discovery, Sepracor, was the moderator for the program. Dr. Nancy Barta, Associate Research Fellow from Pfizer spoke on The Role of a2- Calcium Channel Subunits in the Biological Activity of Pregabalin. Dr. Francesco Belardetti, Director of Ion Channel Research at Neuromed spoke on the Discovery of Calcium Channel Blockers by Sequential Use of Fluorescence-Based Screens. Dr. Valentin Gribkoff, VP of Biology, at Scion Pharmaceuticals spoke on the Discovery and Characterization of Openers of Neuronal and Smooth Muscle Potassium Channels. The symposium was concluded by a key note presentation by Dr. Mark Suto, VP of Chemistry at Icagen. The symposium was well attended by 75 participants.

148

The third and the last symposium for the year 2005, was held on December 8, 2005 at Holiday Inn in Woburn, MA. The meeting was a big success. There were 200 participants who enjoyed cutting edge research results that were presented by four well-known speakers from the pharmaceutical industry. Dr. Mark Tepper , Founder and CEO of CytRx Pharmaceuticals, spoke about how RNAi technology can be used to develop molecular medicines to treat obesity and diabetes. Dr. Sridhar Prasad from Merck Pharmaceuticals addressed how X-ray crystallography is used to understand the interactions of small molecules with target proteins, which in turn can help scientists to design new molecules for the treatment of diabetes. Dr. Murali Ramachandra from Aurigene Technologies of Bangalore, India talked about the design and synthesis of DPPIV inhibitors for the treatment of type II diabetes. The social hour, networking and dinner were part of the program. The keynote speaker for the evening was Dr. Edwin B. Villhauer from Novartis Pharmaceuticals. Edwin told the story of Vildagliptin, a compound that he initiated work on about 10 years ago, which is now in Phase III clinical trials. Dr. Raj (SB) Rajur, Founder, Chairman and CEO of CreaGen Biosciences, Inc., a Woburn-based Drug Discovery Company, is the Program Chair for NESCS Medicinal Chemistry Division, and he welcomed the guests and participants. Dr. Norton Peet, an International Pharmaceutical Consultant and meeting co-chair, from North Andover, gave an introductory presentation and moderated the symposium. The symposium was concluded with the token of respect to the speakers by the program Chair, Dr. Rajur

The following is a description of the three symposia held this year.

Medicinal

Chemistry Group Northeastern Section

American Chemical Society

SYMPOSIUM May 19, 2005

Symposium: NEW TARGETS FOR TYPE II DIABETES

Organized by the Medicinal Chemistry Section of the Northeastern Section, American Chemical Society

Thursday - May 19th, 2005 Radisson Hotel, 15 Middlesex Canal Park Road, Woburn, MA

3.00 pm Refreshments 3.15 pm Introductory Remarks Norton Peet, North Andover, MA 3.30 pm Balaglitazone, a New Partial PPAR-γγγ Agonist for Type-II Diabetes Javed Iqbal, Dr. Reddy’s Laboratories, Hyderabad India

149

4:30 pm Preservation of Beta Cell Function in Diabetes by kir6.2/SUR1 Selective Openers of KATP Channels. John Bondo Hansen, Novo Nordisk A/S, Denmark 5.30 pm Social Hour 6.30 pm Dinner 7.45 pm Biostructure-based Development of Inhibitors of PTP1B Steve Tam, Wyeth Research, Cambridge, MA

Dinner reservations should be made no later than 12:00 noon on Thursday, May 12, 2005. Register online with a credit card or paypal account at: mcg.mollyguard.com. If you prefer to pay at the door, please contact Marilou Cashman at (800) 872-2054 or (508) 653-6329 or [email protected]. Reservations not canceled at least 24 hours in advance must be paid. Members, $28.00; Non-members, $30.00; Retirees, $15.00; Students, $10.00. Anyone who needs handicapped services/transportation, please call a few days in advance so that suitable arrangements can be made.

Directions to Radisson Hotel http://www.radisson.com/woburnma A. From Boston - Cambridge - Points North: Take Route I-93 to Route 95/128 West. After 1 mile, take Exit 35 South to Route 38 (Main Street). *After about 500 feet at the traffic light, turn right into Middlesex Canal Street to the hotel entrance. B. From the West: Take Route 95/128 North to Exit 35 South (Route 38 - Main Street. Follow directions from * above. THE PUBLIC IS INVITED

Javed Iqbal Balaglitazone, a New Partial PPAR-γγγ Agonist for Type-II Diabetes

Type II diabetes is characterized by defective insulin action leading to hyperinsulinemia and hyperglycemia. Thiazolidinediones (TZD’s) containing drugs like Rosiglitazone or Pioglitazone are known to activate PPAR-γ and cure type II diabetes. However, the marketed TZD’s lead to edema and body weight gain. It is known that the drugs which activate PPAR-γ act through adipose differentiation and in turn reduce free fatty acids and plasma glucose leading to adipogenesis. If the drug can have a partial PPAR-γ activation to the extent required, then it can have its effects on plasma glucose without causing much adipogenesis. In our program on PPAR- activators we have designed TZD derivatives which can reduce plasma glucose with less adipogenesis. The SAR of these TZD derivatives gave Balaglitazone which has 70% of PPAR- transactivation compared to rosiglitazone and showed partial agonism in competitive binding assay. Balaglitazone has shown good efficacy in db/db and ob/ob mice models at 3mg/kg. In zucker fa/fa rats it shows insulin sensitization effects by 70% reduction in insulin and 80% reduction in free fatty acids at 3mg/kg dose. Balaglitazone is now in phase-II clinical trials.

Javed Iqbal received his PhD in organic chemistry from Delhi University, India in 1977. He went to Cambridge University to work as a post-doctoral fellow with Prof. Ian Fleming, FRS. He subsequently moved to Oxford University in 1982 as a fellow of Wolfson college and worked with Prof. Sir J. E. Baldwin, FRS on Penicillin biosynthesis. After teaching for a year at University of Montpellier, France he returned to India in 1984 and joined IIT Kanpur as a faculty in the department of chemistry and became a professor there in 1990. He made a switch from academia to industry and joined Dr. Reddy’s research foundation, Hyderabad as senior vice-president of research in the year 2000. After spending a year as Director of Regional Research Laboratory (CSIR), Trivandrum he came back to Dr. Reddy’s Laboratories Ltd. in January 2003 and was given a title of distinguished research scientist and global head of discovery chemistry. He has 25 years of teaching and research experience and has 110 research publications in international journals. He also holds 10 global patents on new drug molecules. He has guided 12 PhD and 30 M. Sc. students at IIT Kanpur. He was a visiting professor at University of Notre Dame, USA (1989-90) and University of Okayama, Japan ( 1994). He has also taught at New Mexico State University, USA during 1997-2000 in the summer semesters. He is a fellow of Indian academy of sciences, Bangalore and Indian national Science academy, New Delhi. His research interest include synthetic organic chemistry and discovery of new drugs in the area of diabetes, cancer and cardiovascular diseases.

150

John Bondo Hansen Preservation of Beta Cell Function in Diabetes by kir6.2/SUR1 Selective Openers of KATP Channels.

Diabetes is characterized by loss of beta cell function, which initiates before the clinical onset of the disease. In type 1 diabetes it is a rapid autoimmune process leading to a nearly complete loss of beta cell mass while it in type 2 diabetes is a slowly progressing impairment associated with insulin resistance. It is hypothesized that beta cell hyperactivity plays a role in loss of beta cell function and subsequent beta cell death and that beta cell rest therefore could be used to prevent and treat diabetes. Beta cell rest can be achieved by openers of Kir6.2/SUR1 KATP channels. Several structural diverse compounds have been characterized as selective openers of Kir6.2/SUR1 KATP channels. Among these are compounds, which potently inhibit insulin release to induce beta cell rest in vitro and in vivo. Such compounds have been found active in preclinical models of diabetes and based on these data NN414 were selected for development. The presentation will describe the rationale for using beta cell rest as a treatment concept, the identification and characterization of selective KATP channel openers and the ability of such compounds to preserve beta cell function.

John Bondo Hansen is currently Vice President of Medicinal Chemistry at Novo Nordisk A/S. Prior to this position, John received his M. Sc. in biochemistry and PhD (1982) in bioorganic chemistry from University of Copenhagen. He worked as research assistant (1979-1980) at Texas A&M University with Prof. I. Scott. Then he moved to University of Copenhagen as research associate (1982-1983). From 1983-1987 he worked as research scientist in discovery division at Ferrosan A/S, Denmark. In 1987 he joined Novo Nordisk A/S, Denmark, as Department manager, where he is now Vice President of Medicinal Chemistry.

Steve Tam Biostructure-based Development of Inhibitors of PTP1B

Protein tyrosine phosphatases (PTPs) are a large family of diverse molecules that play an important role in both activating and attenuating a wide variety of cellular responses. One of these phosphatases, protein tyrosine phosphatase 1B (PTP1B), is clearly involved in attenuating insulin signaling, and much effort has been devoted towards the development of inhibitors of this enzyme as a therapeutic approach to treat insulin resistance and type 2 diabetes. Wyeth’s program started with a weak, but well characterized reversible, competitive inhibitor of PTP1B as a lead (Ki ~230 µM). This talk will cover the iterative bio-structure guided medicinal chemistry and the approach used in optimization of in vivo efficacy.

Steve Tam received his B.Sc. degree with cum laude in the Chinese University of Hong Kong in 1968. After staying two more years as the organic chemistry laboratory instructor at the University, he joined Professor Fraser-Reid’s group at the University of Waterloo in Canada for his post-graduate study and received his Ph.D. degree in 1974. He then moved to United States and spent five years at the Memorial Sloan Kettering Cancer Center in New York on cancer research before he joined Hoffmann La Roche in 1979. In the subsequent 19 years, Steve conducted a variety of research projects spanning three therapeutic areas, including the successful development of two anti-HIV drugs and some novel Antisense technologies. In 1995, he became the Director of the 98-member Chemistry Technology Department at Roche, responsible for Combinatorial Chemistry, Process Research and Kilo Laboratory, and the Biostructure Group. In 1998, he joined Genetics Institute and helped to expand the chemistry effort in their small molecule drug discovery program. That group is now part of the Chemical & Screening Sciences Department at Wyeth supporting drug discovery in the areas of inflammation, cardiovascular and metabolic diseases. E.Mail: [email protected]

151

September Meeting

The 862nd Meeting Northeastern Section

of the American Chemical Society

Northeastern Section

of the

American Chemical Society

Symposium: ION CHANNEL DRUG DISCOVERY

Organized by the Medicinal Chemistry Group of the Northeastern Section, American Chemical Society

Thursday – September 8th, 2005 Marriott Cambridge 2 Cambridge Center (Broadway & Third Street), Cambridge, MA

1.00 pm – 4:00 pm Symposium Moderator Mark Varney, VP of Drug Discovery, Sepracor, Inc. Speakers in order of appearance: Nancy Barta, Associate Research Fellow, Pfizer The Role of a2- Calcium Channel Subunits in the Biological Activity of Pregabalin Francesco Belardetti, Director of Ion Channel Research, Neuromed Discovery of Calcium Channel Blockers by Sequential Use of Fluorescence- Based Screens, Automated and Manual Patch-Clamp Valentin Gribkoff, VP of Biology, Scion Pharmaceuticals Discovery and Characterization of Openers of Neuronal and Smooth Muscle Potassium Channels Mark Suto, VP of Chemistry, Icagen Approaches to Ion Channel Modulators

4:00 pm – 5:00 pm Networking Cocktail Party

Cocktail party reservations should be made no later than 12:00 noon on Thursday, September 1, 2005. Call Marilou Cashman at (800) 872-2054 or (508) 653-6329 or respond by e-mail to [email protected]. Pay at the door by cash or check (no credit cards or purchase orders). Reservations not canceled at least 24 hours in advance must be paid. Members and Non-Members $10.00; Retirees and Students, 5.00. Anyone who needs handicapped services should call a few days in advance so that suitable arrangements can be made.

Directions to Cambridge Marriott

From the South: Take I-95 North to I-93 North. Take Exit 26 and follow the signs to Storrow Drive. Go on Storrow Drive for approximately ¼ mile. Take the LEFT EXIT FOR GOVERNMENT CENTER/KENDALL SQUARE. At the bottom of the exit,

152

turn right (onto Longfellow Bridge). Longfellow Bridge turns ito Broadway. After the first set of lights, the hotel will be on the left.

From the West: Take I-90 East (Mass. Pike) to Exit 18 (Allston/Cambridge). Bear right towards Cambridge. Go straight over the River St. Bridge onto River Street. Follow River Street, which turns into Prospect Street, for four blocks and turn right onto Broadway. Go through five lights and the hotel will be on the right.

THE PUBLIC IS INVITED

December Meeting

Northeastern Section The 865th Meeting American Chemical Society of the Northeastern Section of the American Chemical Society

Symposium

NEW TARGETS FOR TYPE II DIABETES (Part II) Organized by the Medicinal Chemistry Section of the Northeastern Section, American Chemical Society

Thursday - December 8th, 2005 Holiday Inn Select Hotel, 15 Middlesex Canal Park Road, Woburn, MA

3.00 pm Refreshments 3.15 pm Welcome Raj (SB) Rajur, Program Chair 3.20 pm Introductiory Remarks Norton Peet, North Andover, MA 3.30 pm RNAi Technology Drives the Development of Molecular Medicines to Treat Obesity & Type II Diabetes Mark Tepper, CytRxCorporation, Worcester, MA 4:30 pm Development of DPPIV Inhibitors Using High Throughput Crystallography G. Sridhar Prasad, Merck & Co., Inc., West Point, PA 5:30 pm Design of DPPIV Inhibitors for the Treatment of Type 2 Diabetes Subramanyah Hosahalli, Aurigene Discovery Technologies, Bangalore, India 6.30 pm Social Hour 6.45 pm Dinner 7.45 pm The story of Vildagliptin (LAF237): A DPP4 inhibitor for the treatment of type 2 diabetes. Edwin B. Villhauer, Novartis Pharmaceuticals, East Hanover, NJ

153

Dinner reservations should be made no later than 12:00 noon on Thursday, December 1, 2005. If you prefer to pay at the door, please contact Marilou Cashman at (800) 872-2054 or (508) 653-6329 or [email protected]. Reservations not canceled at least 24 hours in advance must be paid. Members, $28.00; Non-members, $30.00; Retirees, $15.00; Students, $10.00. Anyone who needs handicapped services/transportation, please call a few days in advance so that suitable arrangements can be made.

Directions to Holiday Inn Select Hotel (Previously Radission) http://www.radisson.com/woburnma

C. From Boston - Cambridge - Points North: Take Route I-93 to Route 95/128 West. After 1 mile, take Exit 35 South to Route 38 (Main Street). *After about 500 feet at the traffic light, turn right into Middlesex Canal Street to the hotel entrance. D. From the West: Take Route 95/128 North to Exit 35 South (Route 38 - Main Street. Follow directions from * above. THE PUBLIC IS INVITED

Mark Tepper RNAi Technology Drives the Development of Molecular Medicines to Treat Obesity & Type II Diabetes

CytRx Laboratories have developed powerful new RNAi gene silencing technology to drive the discovery and development of both traditional small molecule and new RNAi-based therapeutics. This talk will focus on our strategy of applying high throughput RNAi based screens and target validation technology in metabolic tissues to decode the function of key targets for treating obesity and diabetes. Using this technology we have identified a number of novel drug target which we have begun to develop small molecule and RNAi based therapeutics for the treatment of obesity, diabetes and diabetic complications.

Mark Tepper is President and co-founder of CytRx Laboratories, Worcester, MA (formerly Araios, Inc.) and Senior Vice President of CytRx Corp. Los Angeles, CA. He previously served as President and CEO of Arradial, Inc., an Oxford Biosciences Venture backed company developing a novel microfluidics based drug discovery platform. From April 1995 to March 2002, Dr. Tepper served in a number of senior management roles at the US based Serono Pharmaceutical Research Institute most recently as Vice President, Research and Operations and Executive Director of Lead Discovery. His responsibilities included the discovery and development of new medicines in the area of endocrinology, metabolism, oncology, and immunology. While at Serono, Dr. Tepper invented a 2nd generation Interferon drug for MS called InferceptTM, advancing the drug from discovery to clinical phase II. From 1988 to 1995, Dr. Tepper held a variety of functional and project based roles at the Bristol Myers Squibb Pharmaceutical Research Institute working on the discovery and development of small molecule and biologic therapeutics in the area of Oncology and Immunology. Prior to BMS, Dr. Tepper was a post-doctoral fellow at the University of Massachusetts Medical School in the laboratory of Dr. Michael Czech. Dr. Tepper received his Ph.D. in Biochemistry and Biophysics from Columbia University in 1985, and his B.A. in Chemistry from Clark University with highest honors in 1979.

Sridhar Prasad Development of DPPIV Inhibitors Using High Throughput Crystallography

Dipeptidyl peptidase IV (DPPIV) is a member of the prolyl oligopeptidase family of serine proteases. DPPIV removes dipeptides from the N terminus of substrates including chemokines, neuropeptides and peptide hormones. Studies to date indicate that DP4 plays an important role in regulating insulin levels in the body. In early-stage clinical trials conducted primarily by large pharmaceutical companies, orally delivered DP4 inhibitors reduced blood glucose and increased insulin response in patients. These data indicate that small-molecule inhibitors that target DP4 could be potential treatments for major human diseases including type II diabetes, obesity, high cholesterol and other metabolic syndromes. Structure-Based Drug Design (SBDD, also known as rational drug design) is a

154

technique that accelerates the drug discovery process by utilizing structural information to improve the lead optimization process. This technique applied on a high throughput mode for the determination of the three dimensional structure of DPPIV followed by rapid generation of co-crystal structures led to the development of three preclinical candidates in a period of 18 months. The strategy and results of these preclinical development will be presented.

Sridhar Prasad is currently a research fellow in the structural Biology Department, at Merck & Co., Inc., West Point, PA. Prior to this position, Sridhar served as an associate director of crystallography at Syrrx Inc. Sandiego CA, where he was leading the DPPIV drug discovery program. Sridhar, received his PhD in biomolecular crystallography from Indian Institute of Science Bangalore, India and did his Postdoctoral work at the University of Minnesota and Scripps Research Institutes. Sridhar holds four US patents and published more than 50 papers in peer reviewed journals.

Hosahalli Subramanyah Design of DPPIV Inhibitors for the Treatment of Type 2 Diabetes

Design of novel DPPIV inhibitors will be discussed during the presentation Hosahalli Subramanyah received his PhD degree from the Indian Institute of Science in Bangalore, India, and was a Postdoctoral Fellow in the Department of Molecular Biophysics and the Dunn School of Pathology at Oxford University, in the United Kingdom. Subsequently, Dr. Subramanyah became an Assistant Director at the Central Drug Research Institute in Lucknow, India, prior to joining Aurigene Discovery Technologies in Bangalore. Presently, Dr. Subramanyah is the Head of Structure-Guided Drug Design at Aurigene.

Edwin B. Villhauer The Story of Vildagliptin (LAF237): A DPP4 inhibitor for the treatment of type 2 diabetes

Dipeptidyl peptidase IV (DPP4) inhibition has the potential to become a valuable therapy for type 2 diabetes. The synthesis and structure activity relationship of a new DPP4 inhibitor class, N-substituted-glycyl-2- cyanopyrrolidines, are described as well as the path that led from clinical development compound 1-[2-[5- cyanopyridin-2-yl)amino]-ethylamino]acetyl-2-cyano-(S)-pyrrolidine (DPP728) to its follow-up, 1-[[(3-hydroxy-1- adamantyl) amino]acetyl]-2-cyano-(S)-pyrrolidine (Vildagliptin, LAF237). The pharmacological profile of Vildagliptin in obese Zucker fa/fa rats along with pharmacokinetic profile comparison of DPP728 and Vildigliptin in normal cynomolgus monkeys and humans is discussed. The results suggest that Vildagliptin is a potent, stable, selective DPP4 inhibitor possessing excellent oral bioavailability and potent antihyperglycemic activity with potential for once-a-day administration. The results from recent clinical studies will be discussed during the congress.

Edwin Villhauer is currently a Principal Fellow Research Scientist in Process Research at Novartis Pharmaceuticals in East Hanover, New Jersey. Until the move of Novartis Research to Boston in 2003, he worked for over 17 years as a medicinal chemist in preclinical asthma, cardiovascular, obesity and diabetes programs at Sandoz and then Novartis in New Jersey as well as Basel, Switzerland. He has led, and championed numerous diabetes and obesity programs while specializing in protease inhibition and combinatorial chemistry. Due to his inventions of Novartis’s two diabetes development compounds in the DPP4 inhibitor field (DPP728 and its successor, LAF237), he was recently awarded the title of Novartis Leading Scientist. He is the author of over two dozen publications and inventor of 9 issued US patents. Dr. Villhauer received his B.S., M.S., and Ph. D. from the University of Rochester.

155

REPORT OF THE MEMBERSHIP COMMITTEE Michaeline Chen, Chair

A total of 945 “Welcome New Member” letters were sent during 2005

Month Date New Transferred Totals Members Members January February March 18 113 74 187 April 25 68 61 129 May September 20 105 59 164 October November 10 173 138 310 December 20 71 83 154

Totals 530 415 945

There were about 50 new members who attended Local Section Dinner Meetings during 2005.

The purpose of the membership committee is to welcome new members, assist and support our members in need and refer them to the appropriate resources; monitor membership in our section and recommend chemists and chemical scientists for membership. I have always provided Membership Applications to non-members who attended our Monthly Dinner Meetings.

More new members are interested in employment opportunities and job information. Some are interested in the National Chemistry Week, others are interested in Government Relations, Hospitality and other functions.

The committee works very closely with Mrs. Karen Piper, Business Manager of The Nucleus. She supplies the labels for the new members’ roster. Our Editor of The Nucleus, Dr. Michael Filosa, places a short note in the monthly issues of The Nucleus to invite New Members to our monthly meeting and dinner. The ACS envelopes are provided by our section secretary, Marilou Cashman.

A copy of my “welcome letter” to new members is attached.

156

Sample Welcome Letter to New Members

November 10, 2005 Dear Colleague,

Congratulations on joining the American Chemical Society and its Northeastern Section. Welcome aboard! We intend to make sure your decision to join was a wise one. We also provide you with a broad range of services and opportunities to help you personally and professionally.

I would like to invite you to be a guest of our section at one of our monthly dinner-lecture meetings of your choice. Our dinner-lecture meetings are usually held on the second Thursday of each month (September through May). Social hour is at 5:30 pm where a table of Career Services Aids and literature will be available. Dinner is at 6:30 pm with a guest speaker to follow. The lectures are on a drop-in basis; reservations are necessary for dinner. Our next monthly Dinner Meeting is:

Thursday, 8 December 2005 at Holiday Inn, Woburn, MA -15 Middlesex Canal Park Rd 3:00 p.m. Symposium : Diabetes II 6:30 p.m. Reception & Dinner 7:45 p.m. Evening Meeting Speaker & Topic: Dr. Edwin B. Villhauer Novartis Phamaceuticals East Hanover, NJ “The Story of Vildagliptin (LAF 237) : A DDP4 inhibitor for the Treatment of Tpye 2 Diabetes”

For dinner reservations please contact our section secretary, Marilou Cashman at 1-800-872-2054 or 508-653-6329, or E-mail: [email protected], on or before the first Thursday of the month (December 1st ) and let her know that you are a new member. We welcome your participation and look forward to meeting you.

Information about our monthly meetings will be provided through the Nucleus, our monthly publication. Have you received a copy of the Nucleus? If not, please contact the Business Manager of The Nucleus, Karen Piper, at 1-978- 456-8622 or e-mail: [email protected]

Once again, welcome to ACS and the Northeastern Section!

Sincerely yours,

Michaeline F. Chen Chair, Membership Committee Northeastern Section, ACS e-mail: [email protected] Tel: 781-235-5201

157

REPORT OF NATIONAL CHEMISTRY WEEK – 2005 Christine Jaworek-Lopes, Chair

On Sunday, October 16, 2005, the Northeastern Section of the American Chemical Society and Wellesley College sponsored and hosted a 2005 National Chemistry Week celebration focusing on the yearly theme The Joy of Toys. For weeks before the celebration, volunteers from Emmanuel College, Simmons College, Suffolk University, Tufts University, and Wellesley College worked out the details of numerous demonstrations and hands-on activities. More than 60 volunteers (from Bridgewater State, Clark University, Emmanuel College, Simmons College, Suffolk University, Tufts University, Wellesley College) ensured than the more than 350 visitors to the daylong event enjoyed a number of hands-on activities and demonstrations relating to the theme.

These activities included: • making Nature Prints using light sensitive paper purchased from www.teachersource.com; • making superballs and slime to discuss polymerization; • making bunny copters to study chromatography; • demonstrating changing the color of Barbie’s hair; • exploring bubble-making using a bubble kit purchased from www.teachersource.com

In order to compare the efficacy of homemade superball preparation, participants were given commercially-made superballs.

Among the highlights of the day were the lecture demonstrations as part of the Phyllis A. Brauner Memorial lectures presented by Dr. Bassam Shakhashiri. These captivating lectures were enjoyed by children and adults alike.

In addition, a toy drive was held on this date. Hundreds of new and gently used toys were donated by visitors to the event. The student affiliates chapter of Suffolk University packaged the toys and sent them on to benefit victims of Hurricane Katrina and Hurricane Rita.

During the summer of 2005, the following organizations were contacted regarding the poster competition in lieu of a mass mailing because of the low number of poster entries in 2004: Boy Scouts, Girl Scouts, New England Association of Chemistry Teachers (NEACT), and Massachusetts Association of Science Teachers (MASS). The number of entrants was even lower this year (two). The winning poster was created by Molly McCarthy, a fifth grader at Job Lane Elementary in Bedford. Both participants received a notepad, certificate, and stuffed moles for their accomplishments.

Throughout the week, volunteers from local schools and industries assisted hundreds of visitors in the week-long celebration in appreciation of chemistry in the world around us.

Christine H. Jaworek-Lopes, Chair National Chemistry Week Northeastern Section, ACS

158

Report on NERM 2005 Morton Hoffman NESACS Representative to the NERM Steering Committee

The 33rd Northeast Regional Meeting was held on the campus of Sacred Heart University in Fairfield, CT, July 14-17, 2005. Linda Farber (Sacred Heart University), Kraig Steffen (Fairfield University), and Mathieu Freeman ( Green Farms Academy) served as General Chair and Co-Program Chairs, respectively. The meeting was dedicated to the memory of Professor Babu George of Sacred Heart University, who led its organization until his death in March, 2004.

Three hundred attendees presented more than 161 papers across the spectrum of chemistry with symposia on nanomaterials, applications of FTIR, nutritional chemistry, organic electrochemistry, microwave chemistry, and environmental chemistry. An extensive chemical education program was held, including sessions and workshops for undergraduates and high school teachers. Special events included the Industrial Innovations Awards Symposium, a spectacular chemical demonstration show, an awards banquet, undergraduate research poster sessions, and a keynote address by ACS President, Bill Carroll. In attendance were Anne O’Brien, District I Director, and candidates for the position of ACS President- Elect. The exposition had 17 exhibitors, and included vendor workshops.

At the end of the meeting, the NERM Steering Committee met and voted to adopt the articles of incorporation that will constitute the bylaws of the Northeast Region, American Chemical Society, Inc., when incorporation is accomplished in Washington, DC, later this year. Nineteen local sections comprise the Northeast Region: Binghamton, Central Massachusetts, Connecticut Valley, Cornell, Corning, Eastern New York, Green Mountain, Maine, Mid-Hudson, New Haven, Northeastern, Northern New York, Norwich, Penn-York, Rhode Island, Rochester, Syracuse, Western Connecticut, and Western New York. Julie Smist (Springfield College) and Richard Cobb (Eastman Kodak) were elected Chair and Vice-Chair of the Region, respectively, through 2007, and Willem Leenstra (University of Vermont) was elected Secretary/Treasurer through 2006. The Region’s plan is to build a treasury of approximately $40,000 over the course of several years to provide seed money for regional meetings, the development of regional programs, and the funding of scholarships. The funds will come from the profits of regional meetings, dues and assessments from local sections in the regions, and private contributions. The next meeting of the Board of Directors of the Region will be held at NERM-2006, October 5-7, in Binghamton, NY.

There will be no NERM in 2007 because the ACS national meeting will be held in Boston in August of that year. Tentatively scheduled is NERM-2008, June 22-26, in Burlington, VT, and bids are being accepted for NERM-2009. The Rochester Section has expressed an interest to host NERM in 2010 despite the fact that the ACS national meeting will again be held in Boston in that year; the arrangement may be feasible given the distance between the two cities. A discussion was held with a representative of the Middle Atlantic Region about holding a joint NERM/MARM in 2011, possibly hosted jointly by the New York, North Jersey, Connecticut Valley, and Northeastern local sections.

159

REPORT OF THE NOMINATING COMMITTEE - 2005 Jean A. Fuller-Stanley, Chair

The Nominating Committee was chaired by Dr. Jean A. Fuller-Stanley, immediate Past-Chair of the Northeastern Section. The following are the results of the balloting for the 2006 ACS officers of the Northeastern Section. There were a total of 504 ballots counted..

NESACS ELECTION RESULTS - 2005 BALLOT

Name Votes Result Position Term

Mukund S. Chorghade 432 Elected Chair-Elect 1 year

Michael Singer 453 Elected Secretary 2 years

Michael E. Strem 466 Elected Trustee 3 years

Doris I. Lewis 415 Elected Councilor 3 years Morton Z. Hoffman 399 Elected Councilor 3 years Christine Jaworek-Lopes 399 Elected Councilor 3 years Mary Burgess 398 Elected Councilor 3 years Donald O. Rickter 387 Elected Councilor 3 years Patrick M. Gordon 384 Elected Alternate Councilor 3 years. Michael Filosa 370 Elected Alternate Councilor 3 years. Lawrence Scott 369 Elected Alternate Councilor 3 years Liming Shao 356 Elected Alternate Councilor 3 years S. B. Rajur 328 Elected Alternate Councilor 3 years Mukund S. Chorghade 223

Henry Brown 416 Elected Director-at-Large 3 years Ernest V. Groman 407 Elected Director-at-Large 3 years

Doris I. Lewis 284 Elected Nominating Committee 1 year E. Joseph Billo 230 Elected Nominating Committee 1 year Nolan Flynn 225 Ernest V. Groman 154

John L. Neumeyer 436 Elected Esselen Committee 4 years Joseph A. Lima 420 Elected Esselen Committee 4 years

Roy G. Gordon 356 Elected Richards Medal Comm. 4 years Paul Davidovits 319 Elected Richards Medal Comm. 4 years Gregory L. Verdine 208

160

REPORT OF THE NORRIS AWARD COMMITTEE - 2005 Howard R. Mayne, Chair

Committee members for 2005:

Professor Howard R. Mayne, University of New Hampshire (Chair) Professor Marietta Schwartz, University of Massachusetts Boston Professor Donald Smith, University of Massachusetts Dartmouth Professor Barry Snider, Brandeis University Professor Jerry Mohrig, Carleton College Professor Mary Virginia Orna, College of New Rochelle Professor John W. Moore, University of Wisconsin, Editor, Journal of Chemical Education

Committee Charge

The James Flack Norris Award for Outstanding Achievement in the Teaching of Chemistry is presented annually by the Northeastern Section to an educator who is both an excellent classroom teacher and whose professional activities have had a wide-ranging effect on chemical education The award consists of an honorarium for $3000 and an award certificate.

A total of five nomination packets was received. Three were updated re-submissions of materials received in previous years. Two were for new nominees. Copies of the files were circulated to the committee. A conference call was held by the committee in May 2005. At this meeting the awardee was decided. The 2005 honoree was Professor Morton Z Hoffman of Boston University. He was honored for his work in undergraduate peer-led team learning, as well as for his great activity in making ACS Meetings accessible to undergraduate students and for his vigorous outreach activities.

Among the other items of business were to determine the chair of the committee for 2006. Marietta Schwartz agreed to fulfill this role. In addition the committee discussed strategies for increasing the pool of nominations for the future. A list of names of potential nominees and potential nominators was generated. The Norris Committee Chair was charged with making contact with the potential nominators. (Fifteen potential nominators were contacted in December 2005. In addition, two nominators for 2005 have agreed to resubmit their nominations in 2006.)

Preliminary notifications of the award were sent to The Nucleus and the Journal of Chemical Education, and appeared in their summer editions. [See Appendix] Also included in the Appendix are a biography of Professor Hoffman and the citation which appeared on the Award Certificate.

The Norris Awards Dinner was held at the Brookline Holiday Inn on November 17, 2005. (Professor Hoffman was unavailable for the second Thursday of the month.) The program for the dinner is included in the Appendix. The attendance was 110. The title and abstract of Professor Hoffman’s talk are included below:

“The Three Guiding Principles of Teaching and Learning”

If the three guiding principles of real estate are location, location, location, then those of teaching and learning must be engagement, engagement, engagement. For the education process to be successful, the students’ minds, imaginations, and very souls must be engaged by

161

the teacher. However, because most college and university chemistry faculty members are not educated about pedagogical theory and practice (as are primary and secondary school teachers), they tend to teach the way they themselves were taught, thereby perpetuating instructor-centered, rather than student-centered, approaches. The result often is, unfortunately, disengagement of the students. In this presentation, a personal evolutionary journey of discovery of the three guiding principles will be recounted.

The after-dinner talk was distinguished by a demonstration of the student-led discussion technique by a group of student participants in the audience. A report of the ceremony was featured in the Chemical & Engineering News, December 12, 2005 (p34). A full report will be featured in the January 2005 edition of The Nucleus.

A Call for Nomination was written and submitted to The Journal of Chemical Education and the Nucleus. (See Appendix.) The Nucleus “Call for Nominations” first appeared on p6 of the December 2005 Nucleus. The same “Call” will appear in the January J. Chem. Ed. It will also be submitted to the ACS Division of Chemical Education Newsletter.

Work was begun on generating an operating manual for the committee. This will be submitted to NESACS on its completion.

Respectfully submitted, Howard R. Mayne, Chair

APPENDIX

Description of the Award

(From the NESACS website.) “The Norris Award is one of the oldest national awards of the American Chemical Society and is presented annually by the Northeastern Section. The recipient is selected from an international list of nominees who have served with special distinction as teachers of chemistry at any level and whose efforts have had a wide-ranging effect on chemical education. The award has been given for a wide variety of achievements: for outstandingly effective textbooks, lecture demonstrations, or laboratory experiments, for editing the Journal of Chemical Education, for developing the Chemical Educational Material Study Project, or for new ways to teach laboratory courses in chemistry. Always, and this is of the utmost importance, the specific achievement must be coupled with dedicated teaching of chemistry at the graduate, undergraduate, or high school level. The award consists of a certificate and an honorarium.”

Biography of Morton Z. Hoffman, 2005 Norris Awardee

Hoffman received his B.S. degree from Hunter College of the City University of New York in 1955, and an M.S. (1957) and Ph.D. degree (1960) from the University of Michigan. Following postdoctoral work at the University of Sheffield in England, Hoffman joined the faculty at BU in 1961. He was promoted to Associate Professor with tenure in 1967, and to Full Professor in 1971. Mort has served as Associate Chair for Undergraduate Affairs and as Co-Advisor to the award-winning ACS Student Affiliates Chapter at Boston University. In recent years, he has been increasingly involved in developing innovative teaching techniques for the general chemistry course. These have included pioneering work on using peer-led team learning in large classes. He has been the

162

recipient of BU’s Metcalf Cup and Prize for Excellence in Teaching, and was the Founding Director of the Center for Teaching Excellence in the College of Arts and Sciences. Mort Hoffman has been extraordinarily active with the American Chemical Society for over forty years. He is currently chair of the Division of Chemical Education. He was instrumental in strengthening undergraduate attendance at National Meetings, and has long been committed to facilitating chemical education events at Regional Meetings. Recently, he has been active in conveying the vitality of modern chemistry to teachers at all levels both nationally and internationally. Mort has also served the Northeastern Section of the ACS with great distinction, serving on a wide array of committees. He was Chair of the section in 2002, and is a recipient of the section’s Henry Hill Award for Outstanding Service.

Preliminary Notification to JCE and The Nucleus

Morton Z. Hoffman, Professor of Chemistry at Boston University, has been selected as the recipient of the 2005 James Flack Norris Award for Outstanding Achievement in the Teaching of Chemistry. The award will be presented on Thursday November 17, 2005. The award is made annually by the Northeastern Section of the American Chemical Society to recognize an individual whose dedication and excellence in the teaching of chemistry have had wide-ranging effects on the profession. Hoffman received his B.S. degree from Hunter College of the City University of New York in 1955, and an M.S. (1957) and Ph.D. degree (1960) from the University of Michigan. Following postdoctoral work at the University of Sheffield in England, Hoffman joined the faculty at BU in 1961. He was promoted to Associate Professor with tenure in 1967, and to Full Professor in 1971. Mort has served as Associate Chair for Undergraduate Affairs and as Co-Advisor to the award-winning ACS Student Affiliates Chapter at Boston University. In recent years, he has been increasingly involved in developing innovative teaching techniques for the general chemistry course. These have included pioneering work on using peer-led team learning in large classes. He has been the recipient of BU’s Metcalf Cup and Prize for Excellence in Teaching, and was the Founding Director of the Center for Teaching Excellence in the College of Arts and Sciences. Mort Hoffman has been extraordinarily active with the American Chemical Society for over forty years. He is currently chair of the Division of Chemical Education. He was instrumental in strengthening undergraduate attendance at National Meetings, and has long been committed to facilitating chemical education events at Regional Meetings. Recently, he has been active in conveying the vitality of modern chemistry to teachers at all levels both nationally and internationally. Mort has also served the Northeastern Section of the ACS with great distinction, serving on a wide array of committees. He was Chair of the section in 2002, and is a recipient of the section’s Henry Hill Award for Outstanding Service.

2005 Award Citation

To Morton Z Hoffman You receive this award in recognition of your achievements in engaging a wide audience in the science of chemistry. Your energy, dedication and determination have made an impact locally, nationally, and internationally. By making students the focus of the learning process you have captured their interest early in their careers. By promoting undergraduate research you have nurtured that interest and helped steer many into careers in chemistry. By working with your peers and other educators, you have ensured that others engage as passionately in this enterprise as you do. We honor you for your efforts to convey the skill of teaching chemistry to those who practice it, and the excitement of doing chemistry to those who teach it.

Howard R. Mayne Chair, Norris Committee Amy Tapper, Chair NESACS

163

NORRIS AWARD DINNER 2005

Prof. Howard R. Mayne, Chair of the Norris Award Committee, presenting Certificate to Prof. Morton Z. Hoffman, 2005 Norris awardee

Dr. Amy Tapper, Chair of the Northeastern Section, with Prof. Morton Z. Hoffman

Prof. & Mrs. Morton Z. Hoffman

164

Sample Call for Nominations (Submitted to The Nucleus and J. Chem. Ed.)

Call for Nominations James Flack Norris Award for Outstanding Achievement in the Teaching of Chemistry

Nominations are invited for the 2006 James Flack Norris Award for Outstanding Achievement in the Teaching of Chemistry. The Norris Award, one of the oldest awards given by a Section of the American Chemical Society, is presented annually by the Northeastern Section. The Award consists of a certificate and an honorarium of $3,000.

Nominees must have served with special distinction as teachers of chemistry at any level: secondary school, college, and/or graduate school. Since 1951, awardees have included eminent and less widely- known but equally effective teachers at all levels.

The awardee for 2005 was Professor Morton Z. Hoffman of the Department of Chemistry of Boston University.

Nominations should focus on the candidate’s contributions to and effectiveness in teaching chemistry. The nominee’s curriculum vitae should be included. Seconding letters are also an important part of a nominating packet. These may show the impact of the nominee’s teaching in inspiring colleagues and students toward an active life in chemistry and/or related sciences, or may attest to the influence of the nominee’s other activities in chemical education, such as textbooks, journal articles, or other professional activity at the local or national level.

Materials should be of 8 ½ by 11 inch size. The nomination packet should not exceed thirty pages and should not include books or reprints or software.

Please direct questions about the content of a nomination to Professor Marietta Schwarz at the University of Massachusetts-Boston, email: [email protected]. For more information about the Norris Award, see www.nesacs.org.

Send nomination packets (as hard copy, or electronically in Adobe PDF format) to Ms. Marilou Cashman, NESACS, 23 Cottage St., Natick, MA, 01760. email: [email protected].

The deadline for nominations is April 15, 2006.

165

Norris Award Committee 2005, and Affiliations

Term Expires

Dr. Howard R. Mayne 12/31/06 Northeastern Section Dr. Marietta Schwartz 12/31/06 Northeastern Section Dr. Barry Snider 12/31/08 Northeastern Section Dr. Don Smith 12/31/08 Northeastern Section

Dr. Jerry Mohrig 12/31/06 Dr. Mary Virginia Orna 12/31/07 Dr. John W. Moore n.a. - ex officio member as editor of Journal of Chemical Education

Comments Four members of the committee must be from the Northeastern Section, and are elected by the Section. The term is four years. The chair is selected by the committee, and must be from the Northeastern Section. The Editor of the Journal of Chemical Education is an ex officio member of the committee. The remaining two committee members must be ACS members, but not from the Northeastern Section. The term is four years. The committee is responsible for selecting outside members.

From The Nucleus – Call for Nominations for 2005 Award

166

Citation Presented to Professor Morton Z. Hoffman

The Northeastern Section of the American Chemical Society confers the fifty-fourth

James Flack Norris Award for Outstanding Achievement in the Teaching of Chemistry on Morton Z. Hoffman Professor Emeritus, Boston University

In recognition of a career exemplifying excellence in chemical education

You receive this award in recognition of your achievements in engaging a wide audience in the science of chemistry. Your energy, dedication and determination have made an impact locally, nationally, and internationally. By making students the focus of the learning process, you have captured their interest early in their careers. By promoting undergraduate research, you have nurtured that interest and helped steer many into careers in chemistry. By working with your peers and other educators, you have ensured that others engage as passionately in this enterprise as you do. We honor you for your efforts to convey the skill of teaching chemistry to those who practice it and the excitement of doing chemistry to those who teach it.

Howard R. Mayne November 17, 2005 Amy E. Tapper Chair, Norris Award Committee Chair, Northeastern Section

167

From the Norris Award Dinner Invitation

The Board of Directors of the Northeastern Section of the American Chemical Society requests the honour of your presence at the Dinner and Awards Ceremonies on the occasion of the presentation of The James Flack Norris Award for Outstanding Achievement in the Teaching of Chemistry to Professor Morton Z. Hoffman Boston University

on Thursday, November 17, 2005 at Holiday Inn 1200 Beacon Street Brookline, Massachusetts

5:30 o'clock – Social Hour 6:30 o’clock – Dinner 7:45 o’clock – Award Ceremony and Program

R.S.V.P.

168

from the Norris Award Dinner Program:

NORTHEASTERN SECTION

of the

AMERICAN CHEMICAL SOCIETY

Presentation of the Fifty-fourth

JAMES FLACK NORRIS AWARD

for

Outstanding Achievement in the Teaching of Chemistry

to

MORTON Z. HOFFMAN

Thursday, November seventeenth Two thousand five

Holiday Inn Brookline, Massachusetts

169

PROGRAM Holiday Inn Brookline, MA

5:30 P.M. Social Hour 6:30 P.M. Dinner 7:45 P.M. Norris Award Ceremonies

Amy E. Tapper Chair, Northeastern Section, Presiding

James Flack Norris Myron S. Simon Archivist, Northeastern Section

Introduction of Award Recipient Glenn Crosby Professor Emeritus, Washington State University

Presentation of Award Howard R. Mayne Chair, Norris Award Committee

Norris Award Address “The Three Guiding Principles of Teaching and Learning”

Morton Z. Hoffman Professor Emeritus, Boston University

Reception in honor of Professor Hoffman

170

JAMES FLACK NORRIS: THE MAN AND THE AWARD*

The James Flack Norris Award for Outstanding Achievement in the Teaching of Chemistry pays tribute to outstanding contributions to the field of chemical education and in so doing honors the memory of a distinguished teacher of chemistry: James Flack Norris.

The Award The Norris Award is one of the oldest national awards of the American Chemical Society and is presented annually by the Northeastern Section. The recipient is selected from an international list of nominees who have served with special distinction as teachers of chemistry at any level and whose efforts have had a wide-ranging effect on chemical education. The award has been given for a wide variety of achievements: for outstandingly effective textbooks, lecture demonstrations, or laboratory experiments, for editing the Journal of Chemical Education, for developing the Chemical Educational Material Study Project, or for new ways to teach laboratory courses in chemistry. Always, and this is of the utmost importance, the specific achievement must be coupled with dedicated teaching of chemistry at the graduate, undergraduate, or high school level. The award consists of a citation and an honorarium.

The Man James Norris was born in 1871 in Baltimore. He was the fifth of nine children and attended schools in that city and in Washington, D.C. His collegiate career started at Johns Hopkins University, from which he graduated with an A.B. degree, Phi Beta Kappa, in 1892. He was strongly attracted by the great and consequently decided to carry out his graduate studies at Johns Hopkins where he investigated complex compounds of selenium and tellurium. In 1895 he obtained his Ph.D. After graduation, Professor Norris served in the Chemistry Department of M.I.T. In 1904 he then moved to the newly founded Simmons College to become its first Professor of Chemistry and to head its School of Science. He remained at Simmons until 1915 except for 1910-11 when, feeling the need for more physical chemistry, he spent a sabbatical with Fritz Haber at Karlsruhe. After one year at Vanderbilt University, Norris returned to M.I.T. where he remained for the next 24 years as an enthusiastic and successful teacher of chemistry. On February 4, 1902 he was married in Washington, D.C. to Anne Bent Chamberlin, daughter of an Army Captain. They had no children. Professor Norris died in Cambridge, Massachusetts on August 4, 1940.

In 1916 Norris was a member of the Naval Consulting Board and during World War I he served as a Lt. Colonel in the Chemical Warfare Service. After the war, he served for ten years as vice chairman and chairman of the Division of Chemistry and Chemical Technology of the National Research Council.

Although serious when the occasion called for it, the debonair Norris was known as "Sunny Jim" to a host of friends who found him a jovial companion.

His activities in the ACS were many: Chairman of the Northeastern Section in 1904 and President of the National Society in 1925 and 1926. As President of the Society, he did much to improve and clarify the finances of the society. He was also active in the National Research Council and in IUPAC, serving as vice president of the latter from 1925-28. He was an honorary member of the Rumanian Chemical Society and of the Royal Institute of Chemistry in Great Britain. In 1937, he received the gold medal of the American Institute of Chemists for "outstanding service as a teacher and as an investigator." Norris was one of the first chemists to study the structure- reactivity relationship of organic compounds on a systematic basis. Between 1912 and 1922 he authored four influential textbooks in inorganic and organic chemistry. The income from those texts, at least in part, formed the foundation of the bequest from Mrs. Norris to the Northeastern Section in 1948. The purpose of this bequest, to quote the will of Mrs. Norris, is "to keep green the memory of James Flack Norris."

The Norris Fund has grown over the years with judicious management by the Trustees of the Northeastern Section. From its income the Section sponsors two James Flack Norris Awards: the James Flack Norris Award in Physical Organic Chemistry, administered by the National ACS, and the James Flack Norris Award for Outstanding Achievement in the Teaching of Chemistry. Tonight's recipient joins a distinguished group of predecessors.

*Taken from the biographical memoir of James Flack Norris by John D. Roberts and from the biography of James Flack Norris given by Joseph Bornstein at the presentation of the James Flack Norris Award for Outstanding Achievement in the Teaching of Chemistry.

171

FROM THE WEB SITE

Norris award for Morton Hoffman James Flack Norris award for Morton Hoffman Morton Z. Hoffman, Professor of Chemistry at Boston University, has been selected as the recipient of the 2005 James Flack Norris Award for Outstanding Achievement in the Teaching of Chemistry. The award will be presented on Thursday November 17, 2005. The award is made annually by the Northeastern Section of the American Chemical Society to recognize an individual whose dedication and excellence in the teaching of chemistry have had wide-ranging effects on the profession.

Hoffman received his B.S. degree from Hunter College of the City University of New York in 1955, and an M.S. (1957) and Ph.D. degree (1960) from the University of Michigan. Following postdoctoral work at the University of Sheffield in England, Hoffman joined the faculty at BU in 1961. He was promoted to Associate Professor with tenure in 1967, and to Full Professor in 1971. Mort has served as Associate Chair for Undergraduate Affairs and as Co- Advisor to the award-winning ACS Student Affiliates Chapter at Boston University. In recent years, he has been increasingly involved in developing innovative teaching techniques for the general chemistry course. These have included pioneering work on using peer-led team learning in large classes. He has been the recipient of BU’s Metcalf Cup and Prize for Excellence in Teaching, and was the Founding Director of the Center for Teaching Excellence in the College of Arts and Sciences.

Mort Hoffman has been extraordinarily active with the American Chemical Society for over forty years. He is currently chair of the Division of Chemical Education. He was instrumental in strengthening undergraduate attendance at National Meetings, and has long been committed to facilitating chemical education events at Regional Meetings. Recently, he has been active in conveying the vitality of modern chemistry to teachers at all levels both nationally and internationally. Mort has also served the Northeastern Section of the ACS with great distinction, serving on a wide array of committees. He was Chair of the section in 2002, and is a recipient of the section’s Henry Hill Award for Outstanding Service.

The 2005 Norris Award Committee is: Howard Mayne (University of New Hampshire, Chair); Marietta Schwartz (University of Massachusetts, Boston); Don Smith (University of Massachusetts, Dartmouth); Barry Snider (Brandeis University); Jerry Mohrig (Carleton College); Mary Virginia Orna (College of New Rochelle); John Moore (University of Wisconsin, Editor of the Journal of Chemical Education.)

REPORT OF THE PROFESSIONAL RELATIONS COMMITTEE - 2005 Submitted by Mukund S. Chorghade

Truman and Arlene Light, in 2005 resigned as Chairs of the Career Services Committee of this section and were replaced mid-year by Dr. Mukund S. Chorghade. The section owes a tremendous debt of gratitude to Ted and Arlene for the yeomen service they rendered. Mukund attended both National Meetings at San Diego and Washington DC, actively participating in the work of the ACS Department of Career Services in reviewing resumes and conducting mock interviews. Mukund also gave a plenary lecture in the Presidential Event symposium on "Chemistry Enterprise 2015: Where in the World Will We Be?" at the ACS National Meeting in San Diego in March. Dr. Daniel Eustace was a most welcome and effective contributor to these. Special accolades are due to him for redesigning and participating in several innovative ACS presentations and personally leading highly and superbly interactive and novel workshops on interviewing, career development etc. There was considerable audience participation from employers and interviewees.

Dan Eustace also presented at an afternoon Career Services Employment Seminar that was held in March preceding the regular meeting of the Northeastern Section. A lecture on Resume

172

Presentations was presented and publications of the ACS National Employment Services were distributed. These publications were also distributed at each of the monthly meetings. Also, at the monthly meetings assistance with employment was available. Mukund also presented a workshop at the Mass College of Pharmacy on October 25

I am also grateful to the Northeastern YCC for organizing a highly successful Career Fair For their innovative efforts with such large attendance and benefits to local area members they received the ChemLuminary Award in Washington in September for their efforts. The YCC has been an extraordinarily active and proficient group; the officers and membership have to be complimented for their innovative contributions.

The Chair-elect was assisted in planning the annual October Professional Relations meeting which included presentations of 50-year pins and the Henry Hill Award for Outstanding Local Services.

Mukund Chorghade was privileged to be elected the National Program Chair for the Division of Professional Relations (PROF) Three standing symposia have been added: these will be presented in conjunction with CEPA, IUPAC and Department of Career Services at all future National meetings

What does it take to succeed in the pharmaceutical / biopharmaceutical industry?"

The pharmaceutical sector has traditionally been a vibrant, innovation-driven and highly successful component of industry at large. In recent years, a confluence of spectacular advances in chemistry, molecular biology, genomic and chemical technology and the cognate fields of , chromatography and crystallography have led to the discovery and development of numerous novel therapeutic agents for the treatment of a wide spectrum of diseases. In order to facilitate this process, there has been a significant and noticeable effort aimed at improving the integration of discovery technologies, chemical outsourcing for route selection / delivery of active pharmaceutical ingredients, drug product formulations, clinical trials and refined deployment of information technologies. Multi-disciplinary and multi-functional teams focusing on lead generation and optimization have replaced the traditional, specialized research groups. To develop a drug from conception to commercialization, the biotechnology / biopharmaceutical industry (which has been highly entrepreneurial) has reached out and established global strategic partnerships with numerous companies.

Four distinguished speakers from the pharmaceutical / biopharmaceutical industries will explain how the work has changed and how project conception and management has evolved over the past 20 years. They will explain how the innovation process / management of projects and the progress from conception to commercialization has changed over the years 2) Working in Nanotechnology: What does it take? The dynamic field of nanotechnology is grabbing the attention of headlines, government funding, investment dollars, and jobseekers. Four distinguished scientists working in the field will discuss the skills and knowledge that don't necessarily come with a traditional scientific education yet are predictors of success in nanotechnology. They will also discuss how a strong grounding in chemistry can be key to a successful career in nanotechnology and to a successful scientific career in general.

173

3) To Ph. D. or not to Ph. D-A guide to the perplexed student Experts will discuss job prospects and career success for chemists at various degree levels and various professional levels.

Mukund S. Chorghade President Chorghade Enterprises 14 Carlson Circle Natick, MA 01760-4205 Tel: 508-651-7809 Fax: 508-651-7920 Cell: 508-308-3891 [email protected]

REPORT OF THE CHAIR–ELECT / PROGRAMS - 2005 Pam Mabrouk

As Program Chair, the Chair–Elect organized those monthly meetings of the Section (speakers, venues, etc.) that were not otherwise within the purview of the special awards committees (Esselen Award, Norris Award) and the Medicinal Chemistry Group.

January 13 Monthly Meeting - Harvard Faculty Club No. attended: 90 Joint meeting with Boston Area Group for Informatics and Modeling (BAGIM) Speaker: Dr. Paul Clemons, Eli & Edythe Broad Institute of Harvard and MIT Topic: Multidimensional Screening: Profiling Small Molecules and Cell States Using High-Throughput Screening and multidimensional Data Analysis

February 10 Monthly Meeting - Northeastern University, Boston, MA *No. registered: 80 Joint Meeting with Northeastern University Student Chapter of the Materials Research Society Speaker: Dr. Shana Kelley, Boston College Topic: “Nanotechnological Approaches to Detecting Disease-Related Biomolecules.” Note: Meeting canceled because of major storm

March 10 Monthly Meeting - Holiday Inn, Brookline, MA No. attended: 50 Joint Meeting with Younger Chemists Committee - Younger Chemists Committee Symposium and Networking Event: Speakers: Dr. Nora Conlon (EPA) – Government Dr. Alexander Kolchinski (Pharm-Eco) – Industry Prof. Oleg Ozerov (Brandeis University) – Academia Topic: Making the Transition from School to a Career: Experiences and Advice Dinner Meeting Speaker: Dr. John Fetzer, Fetzpahs Consulting Topic: Chemistry as a Soft Science

174

April 15 Monthly Meeting - Harvard University No. attended: 110 Gustavus John Esselen Award Speaker: Dr. Jean M. J. Frechet, University of California, Berkeley Recipient of the Gustavus J. Esselen Award for Chemistry in the Public Interest Topic: “Functional Macromolecules: From Design and Synthesis to Applications””

May 12 Monthly Meetng / Education Awards - Northeastern University No. attended: 125 Speaker: Dr. Richard Connell, Pfizer Corporation Topic: “The Central Role of Medicinal Chemistry in Cancer Drug Discovery.” Presentation of Awards: Philip L. Levins Memorial Prize Norris/Richards Undergraduate Research Fellowships Undergraduate Grants-in-Aid Project SEED Certificates Richards Secondary Teaching Awards Aula Laudis Society - Induction of Members Ashdown Examination Prizes Simmons College Prize Phyllis A. Brauner Memorial Book Award

September 8 Monthly Meeting – Radisson Hotel, Woburn, MA No. attended: 130 Joint meeting with Medicinal Chemistry Group Symposium: Ion Channel Drug Discovery Moderator: Mark Varney, Sepracor, Inc. - Introductory Remarks Speaker: Nancy Barta, Pfizer Corp. - The Role of a2- Calcium Channel Subunits in the Biological Activity of Pregabal Speaker: Francesco Belardetti, Neuromed - Discovery of Calcium Channel Blockers by Sequential Use of Fluorescence-Based Screens, Automated and Manual Patch- Clamp Speaker: Valentin Gribkoff, Scion Pharmaceuticals - Discovery and Characterization of Openers of Neuronal and Smooth Muscle Potassium Channels Speaker: Mark Suto, Icagen - Approaches to Ion Channel Modulators

October 20 Monthly Meeting – Northeastern University, Boston, MA No. attended: 75 Henry A. Hill Award for Outstanding Service to the Northeastern Section to Charles E. Kolb 50-Year Members of ACS presented certificates of recognition Speaker: Dr. John C. Amedio, Jr., EPIX Pharmaceuticals, Cambridge, MA Topic: Exploring the Analytical and Organic Chemistry Interface: The Development of MRI Imaging Pharmaceuticals

November 17 Monthly Meeting / Holiday Inn, Brookline, MA No. attended: 115 James Flack Norris Award Speaker: Prof. Morton Z. Hoffman, Boston University Recipient of the James Flack Norris Award for Outstanding Achievement in Teaching Chemistry Topic: The Three Guiding Principles of Teaching and Learning

December 8 Joint Meeting with Medicinal Chemistry Group No. attended: 50 Symposium Topic: New Targets for Type II Diabetes (Part II) Speakers: Norton Peet (North Andover, MA) - Introductory Remarks

175

Mark Tepper, CytRxCorporation, Worcester, MA RNAi Technology Drives the Development of Molecular Medicines to Treat Obesity & Type II Diabetes G. Sridhar Prasad, Merck & Co., Inc., West Point, PA Development of DPPIV Inhibitors Using High Throughput Crystallography Subramanyah Hosahalli, Aurigene Discovery Technologies, Bangalore, India Design of DPPIV Inhibitors for the Treatment of Type 2 Diabetes Dinner Speaker: Edwin B. Villhauer, Novartis Pharmaceuticals, East Hanover, NJ Topic: The story of Vildagliptin (LAF237): A DPP4 inhibitor for the treatment of type 2 diabetes.

Pictures from Mar 2005 Meeting

M. ChorM. Chorghade and Al Viola

Amy Tapper and Lauren Wolfe

Camille Peterson and Pam Mabrouk

Mike Filosa and Dr. Fetzer

176

BOARD OF PUBLICATIONS REPORT FOR 2005 Vivian K. Walworth, Chair

The responsibilities of the BOP comprise oversight and management of both The Nucleus and the NESACS website. In addition, the Chair of the BOP serves as the Chair of the Arno Heyn Memorial Committee, which was formed in March, 2005.

The Board of Publications (BOP) of the Northeastern Section of the American Chemical Society (NESACS) for the year 2005 comprised voting members Vivian Walworth, Chair; Mary Mahaney, Secretary; and Martin Idelson. Non-voting BOP meeting participants included Nucleus Editor Mike Filosa, Associate Nucleus Editor Myron Simon; Advertising Manager Vince Gale, Business Manager Karen Piper,Webmaster Sathish Rangarajan, and former BOP member Joseph Billo, who served as consultant.

Vivian completed her 3-year term at the end of December, 2005, and has been re-appointed to the BOP. As of January 1, 2006, Mary Mahaney will become BOP Chair, and Vivian will serve as Secretary. Vince Gale will continue as Advertising Manager and Karen Piper as Business Manager of The Nucleus.

In late 2005 we submitted a proposed Nucleus budget for the year 2006 to the NESACS Budget Committee. We noted that in 2005 our production costs were higher and advertising revenues lower than in earlier times and that we have been taking steps to overcome these gaps.

In late 2004 Sathish Rangarajan became NESACSWebmaster, replacing retiring Webmaster Sam Kounaves. During the year 2005 Sathish redesigned the website, and we recruited both Michele Mandrioli and Rachel Schindler as members of the web team. There have been some problems regarding keeping the site up to date, and we are taking steps to improve this situation in 2006.

In my capacity as Chair of the Arno Heyn Memorial Committee I polled the entire committee regarding nominations and the selection of prize recipients. The award recognizes persons who have made significant contributions to the publications of NESACS. Members of the 2005 committee were Nucleus Editor Mike Filosa, Awards Chair Mike Dube, Directors Myke Simon and Wally Gleekman, and non- voting member Section Chair Amy Tapper, ex officio. The chosen recipients were Sam Kounaves, former webmaster, and Mark Spitler, former Nucleus editor. Each was invited to designate a book prize. We obtained the chosen books, inserted commemorative bookplates, and made the presentations at the November NESACS meeting. Both of Arno Heyn’s sons attended that meeting as guests of the Section.

Following are segments of this BOP report provided respectively by Nucleus Editor Mike Filosa and Webmaster Sathish Rangarajan.

The Nucleus (Mike Filosa)

On January 1 I became the editor, replacing Mark Spitler. Mark did a marvelous job of preparing me for the job, and I was in good hands with the editorial team he had put in place, which included Associate Editors Myron Simon, Nancy Simons, and Ao Zhang. Their experience and the professionalism and skill of Harvey Steiner made the transition to the Editor's job relatively painless. We were able to meet all of our production deadlines and publish the Nucleus on time and within budget. However, we were under constant pressure to keep the page costs down in the face of decreasing advertising revenue and increased production costs. This will be an ongoing theme in the coming year.

177

The consistent contributions of Myke Simon, Morton Hoffman and Martin Freier accounted for much of the content of the Nucleus and their contributions were greatly appreciated. Ms. Ying Wei joined the editorial staff as a photographer, and Sheila Rodman joined as an Associate Editor and Calendar Coordinator. They are most welcome additions to the staff. Ao Zhang had to leave the area for a new job, and Don Rickter relinquished his role as Calendar Coordinator. Both will be missed, as their contributions were highly valued. Sadly, Martin Freier passed away suddenly shortly before the writing of this report. He will be missed, both by the editorial staff and the readers of The Nucleus. He will be difficult to replace.

Website (Sathish Rangarajan)

The nesacs.org site has been active over the last year, with an average daily hit of about 1000 (Table 1). A new streamlined version was formally launched in the last week of March. The new site is 25% leaner and presents an easier interface for navigation. The most visited pages include the ones relating to the Avery Ashdown examination, the local seminar calendar, The Nucleus, and the job postings (Table 2).

At 195 MB, the current disk consumption is well below the allotted space of 800 MB. The NESACS web team now includes Rachel Schindler, who is in charge of the Local Seminar Calendar and links therein, and Michele Mandrioli, who is responsible for the Photo Gallery.

Table 1

Daily Avg Monthly Totals Month Hits Files Pages Visits Sites KBytes Visits Pages Files Hits

Nov 2005 315 184 89 37 826 702941 906 2145 4424 7561 Oct 2005 1024 542 232 111 2845 2139723 3456 7213 16820 31750 Sep 2005 1439 772 215 106 2507 1791084 3200 6457 23169 43180 Aug 2005 709 378 217 99 2227 1812449 3094 6745 11739 22005 Jul 2005 592 293 183 101 2013 1327190 3136 5679 9084 18357 Jun 2005 631 319 195 110 2144 1510768 3314 5868 9588 18933 May 2005 832 422 266 127 2315 1721102 3948 8272 13085 25797 Apr 2005 1136 531 348 187 3089 1676705 5627 10460 15937 34080 Mar 2005 1780 1024 388 212 3967 3529539 6601 12046 31759 55189 Feb 2005 1476 892 344 203 3465 2996678 5701 9633 24993 41347 Jan 2005 1145 712 350 185 3147 2010935 5736 10857 22092 35508

Totals 21225355 44763 85422 182736 333767

178

Table 2 - Top 60 URLs

# Hits KBytes URL

1 1052 2.44% 19723 1.10% /discuss/showthread.php 2 893 2.07% 6922 0.39% /nesacs-style.css 3 870 2.01% 14498 0.81% / 4 708 1.64% 6028 0.34% /discuss/clientscript/vbulletin_global.js 5 669 1.55% 3958 0.22% /discuss/clientscript/vbulletin_menu.js 6 467 1.08% 9768 0.55% /discuss/forumdisplay.php 7 452 1.05% 8598 0.48% /Images/mort-hoffman.jpeg 8 210 0.49% 4079 0.23% /discuss/newreply.php 9 196 0.45% 7894 0.44% /Careers/job-postings.html 10 167 0.39% 3620 0.20% /News/seminars.html 11 139 0.32% 989 0.06% /discuss/register.php 12 128 0.30% 1403 0.08% /discuss/ 13 112 0.26% 29892 1.67% /Events/Ashdown/ashdown2005-exam.doc 14 110 0.25% 967 0.05% /TheNucleus/thenucleus.html 15 105 0.24% 1650 0.09% /News/news.html 16 105 0.24% 662 0.04% /discuss/clientscript/vbulletin_md5.js 17 104 0.24% 1235 0.07% /Careers/careers.html 18 100 0.23% 465 0.03% /discuss/login.php 19 99 0.23% 1137 0.06% /AboutNESACS/nesacs.html 20 98 0.23% 342 0.02% /Events/events.html 21 97 0.22% 476 0.03% /Events/Ashdown/ashdown.html 22 88 0.20% 125 0.01% /discuss/clientscript/vbulletin_editor.css 23 88 0.20% 364 0.02% /discuss/clientscript/vbulletin_editor.js 24 88 0.20% 584 0.03% /discuss/clientscript/vbulletin_stdedit.js 25 84 0.19% 37 0.00% /cgi-bin/mail.vws 26 81 0.19% 451 0.03% /Awards/awards.html 27 75 0.17% 20 0.00% /Redirects/ncw.html 28 71 0.16% 22962 1.28% /TheNucleus/current-issue.pdf 29 69 0.16% 2150 0.12% /News/may2005-medchem-symposium.doc 30 68 0.16% 1134 0.06% /AboutNESACS/nesacs-leaders.html 31 68 0.16% 639 0.04% /discuss/online.php 32 59 0.14% 131 0.01% /Images/photos.html 33 59 0.14% 1900 0.11% /News/aug2005-connections2chem.doc 34 57 0.13% 613 0.03% /discuss/newthread.php 35 56 0.13% 20842 1.16% /TheNucleus/Sep05.pdf 36 53 0.12% 1218 0.07% /AboutNESACS/award-winners-2005.pdf 37 53 0.12% 15 0.00% /Redirects/acs-progress-grants4women.html

179

38 52 0.12% 12002 0.67% /TheNucleus/Oct01.pdf 39 47 0.11% 212 0.01% /Awards/Esselen/esselen.html 40 45 0.10% 569 0.03% /Noticeboard/noticeboard.html 41 44 0.10% 17187 0.96% /TheNucleus/Sep04.pdf 42 44 0.10% 477 0.03% /discuss/editpost.php 43 42 0.10% 9062 0.51% /TheNucleus/May01.pdf 44 41 0.09% 10 0.00% /Redirects/scientists-reading-habits.html 45 40 0.09% 581 0.03% /AboutNESACS/nesacs-centennial-history1.html 46 40 0.09% 12552 0.70% /TheNucleus/Apr03.pdf 47 40 0.09% 17329 0.97% /TheNucleus/Dec03.pdf 48 40 0.09% 19031 1.06% /TheNucleus/Oct02.pdf 49 40 0.09% 13025 0.73% /TheNucleus/Summer05.pdf 50 39 0.09% 20 0.00% /discuss/clientscript/vbulletin_thrdpostlist.js 51 38 0.09% 24592 1.37% /TheNucleus/Feb04.pdf 52 38 0.09% 8057 0.45% /TheNucleus/May03.pdf 53 37 0.09% 66316 3.70% /AboutNESACS/annual-report2004.pdf 54 37 0.09% 243 0.01% /AboutNESACS/site-terms.html 55 36 0.08% 48 0.00% /Careers/ 56 35 0.08% 164 0.01% /AboutNESACS/site-privacy.html 57 35 0.08% 7540 0.42% /Events/Ashdown/ashdown2004-exam.pdf 58 34 0.08% 293 0.02% /AboutNESACS/nesacs-centennial-history3.html 59 34 0.08% 182 0.01% /Images/ 60 34 0.08% 9 0.00% /Redirects/aaps-vsp.html

REPORT OF THE RICHARDS MEDAL COMMITTEE - 2005 Charles E. Kolb, Chair

The Richards Medal is awarded every two years by the Northeastern Section for conspicuous achievement in any area of chemistry. It is the section’s oldest and most prestigious award, honoring the first U.S. Nobel laureate in Chemistry. During 2005 the Richards Medal Committee solicited nominations for the 2006 Medal and evaluated those received to select the 2006 medalist. Initial arrangements were also made for the 2006 Award dinner and presentation ceremony.

The Richards Medal Committee, by tradition, consists of members elected by the Northeastern Section of the ACS (NES/ACS), plus the editor of the Journal of the American Chemical Society (JACS) and two ACS members from outside the Northeastern Section selected by the committee’s chair. The committee selecting the 2006 medalist consisted of Prof. Peter Stang of the University of Utah (JACS editor), Prof. Veronica Vaida of the University of Colorado at Boulder and Prof. Thomas Spiro of Princeton University, and NES/ACS members Prof. Patricia Mabrouk, Northeastern University, Prof. Gary Weisman, University of New Hampshire, Prof. Steve Lippard, Massachusetts Institute of Technology, Prof. Paul

180

Davidovits, Boston College, Prof. Roy Gordon, Harvard University and Dr. Charles Kolb, Aerodyne Research, Inc. Dr. Kolb served as the committee’s chair for 2005.

A call for nominations for the 2006 Award was prepared and circulated via e-mail in July to the chairs of C&E News’ 50 highest ranked PhD granting U.S. university chemistry departments as well as to the chairs of most ACS local sections and the chairs of major ACS divisions, based on e-mail addresses in the 2005 ACS “Yellow Book” Directory. C&E News and The Nucleus also published the call for nominations.

Nominations for the Richards Medal are valid for two award cycles. The nominator for the single nominee carried over from the 2004 cycle was contacted and an updated nomination package was received. Eleven additional valid nominations were received in response to the call for nominations. The twelve nominees considered represented 10 U.S. universities, one foreign university, and one U.S. national laboratory. Ten were men and two were women. The committee was very pleased with the large number of very distinguished chemists nominated and found the task of selecting a single medalist challenging.

After multiple ballots, the committee chose Prof. Richard R. Schrock of Massachusetts Institute of Technology as the 2006 Richards medalist. The committee notes that subsequent to his nomination it was announced that Prof. Schrock was to share the 2005 Nobel Prize in Chemistry.

Prof. Schrock will be honored at an award dinner and medal presentation in conjunction with the NES/ACS meeting scheduled for March 9, 2006 at Harvard University. He plans to present an award address titled: Catalytic Reduction of Dinitrogen to Ammonia at Room Temperature and One Atmosphere.

Charles E. Kolb, Chair

181

REPORT OF THE SUMMERTHING COMMITTEE - 2005 Wallace J. Gleekman, Chair

SUMMERTHING 2005

The Northeastern Section of the American Chemical Society maintained its close relationship with the Boston Red Sox who had provided NESACS members with group tickets when tickets were in high demand and difficult to obtain. Games that were made available to NESACS members in 2005 were with the Atlanta Braves, Anaheim Angels, Cleveland Indians, Minnesota Twins and Oakland Athletics.

Part I: May 21, 2005; Red Sox vs. Atlanta; Final Score: Red Sox 5 Braves 7

On a cold raw evening after a rain delay of 30 minutes, Atlanta went out to a 7-0 lead and then held on as the Red Sox tried to rally in a light continuous rain but, alas, it was too little too late. The Red Sox committed four errors during the game. Edgar Rentaria made two errors, Bill Meuller and Mark Bellhorn one each. Tim Wakefield allowed eight hits and six runs in five innings. The Braves’ Kyle Davis who was just promoted from AAA Richmond, toyed with Red Sox for five innings throwing 95 pitches and allowing four hits.

In the 6th inning trailing 7-0, the Sox scored two runs when Kevin Millar singled. In the 7th the Sox scored a single run when Manny Ramirez forced David Ortiz scoring Rentaria. In the 9th Boston made it interesting when Johnny Damon singled, David Ortiz walked, Ramirez doubled scoring Damon and Trot Nixon grounded out scoring Ortiz. But Jason Varitek flied out to left field ending the game. Most of the damp shivering 35,008 fans had left by the end of the seventh inning.

Part II: June 5, 2005; Red Sox vs. Anaheim; Final Score: Red Sox 6 Angels 3

182

Before a sellout crowd of 35,095 the Red Sox hit into three inning ending double plays (first, sixth, eighth), their first four hitters gathered only three hits in14 tries while striking out seven times and were outhit by the Angels 10 to 8. Yet the Boston bullpen (Mike Myers, Mike Timlin and Keith Foulke) kept the door closed as the Sox scored three runs in both the fourth and seventh innings. Wade Miller, the Boston starter, allowed nine hits into the seventh inning leaving with a 3-3 tie on 110 pitches.

The Red Sox had scored their first three runs on three hits, two walks and a sacrifice fly. In the seventh, Bill Meuller was hit by a pitch to start the rally, John Olerud singled and Jay Payton singled to load the bases. Mark Bellhorn hit a sacrifice fly to give the Sox the lead and then David Ortiz doubled scoring Olerud and Peyton. The win bolstered the Red Sox home record to 17-9, the best in the American League East.

Part III: June 28, 2005; Red Sox vs. Cleveland; Final Score: Red Sox 8 Indians 12

The Red Sox had it after six innings (8-5) and then blew it. And it was their reliable relief pitcher, Keith Foulke, who yielded five runs in 1 2/3 innings and allowed the Indians Travis Hafner to slice a bases loaded home run just inside the Pesky Pole in right field. This homer handed the Red Sox their first loss when leading after eight innings since July 19, 2004. The crowd of 35,445 lustily booed Foulke for his lackluster performance. The loss also cut the Bosox lead in the AL East to 1 1/2 games over Baltimore.

After trailing 4-1 in the fifth, the Sox rallied for two in the fifth and five in the sixth. In the sixth Jay Payton singled, Kevin Youkillis doubled, Johnny Damon singled, Edgar Renteria walked, David Ortiz singled, Manny Ramirez singled and Kevin Millar singled. But two runs for the Indians in the eighth and five runs in the ninth spelled doom for the Red Sox. It was the third blown save for Foulke who boosted his earned run average to over 6. Wade Miller, the Boston starter, had not competed a game in all of June. To make matters even worse, in the ninth all three Sox batters grounded out on the first pitch. It was a three pitch inning for Bob Wickman. The only bright spot for the Sox was the three hits for Ortiz.

Part IV: July 30, 2005; Red Sox vs. Minnesota; Final Score: Red Sox 6 Twins 2

The BIG news for this game was not the starting pitcher David Wells, the fact that Edgar Renteria did not make an error, that the Sox remained in first place 2 1/2 games in front of the Yankees, that Johnny Damon got three hits to raise his batting average to .340 but that Manny Ramirez was not in his usual left field position. It was the second time in the last three games that he failed to play. First baseman Kevin Millar was in left field and John Olerud was playing first and batting cleanup. Wells was upset and let everyone especially the media know about it.

With Ramirez out, David Ortiz walked three times but Olerud was up to the task and batted in three runs. The Sox pounded out 14 hits en route to their 6-2 victory, their 12th in their last 13 games. The game also marked the return of outfielder Gabe Kapler after an injury getting 2 hits in 4 at bats. Wells pitched seven scoreless innings retiring 13 consecutive batters before yielding two runs. It was delightful game for the 35,167 loyal fans who witnessed it.

Part V: September 17, 2005; Red Sox vs. Oakland; Final Score: Red Sox 2 Athletics 1

With the Red Sox win over the Athletics 2-1, the Sox maintained their 1 1/2 game lead over the Yankees for first place. Bronson Arroyo, Boston’s starting pitcher, gave up three hits and one run over seven innings for his 13th victory. Jon Papelbon and Mike Timlin finished up allowing just one Oakland hit. Manny Ramirez singled in the first Red Sox run in the first inning and then provided the winning run with a towering home run over the left field wall in the sixth inning. Boston’s first run came when Edgar Renteria singled, David Ortiz singled and then Ramirez singled.

183

Arroyo had one difficult inning - the 5th - when he used 30 pitches. The A’s had two on and no out and then the bases loaded with two outs but managed only to tie the game at 1-1. Renteria committed his 28th error, tops in the major leagues. The Sox keep winning the close ones; yesterday 3-2 and today 2-1. The Red Sox won 15 of 19 games that had been decided from the 7th inning on. A delighted sellout crowd of 35,220 celebrated with a rousing chorus of “Sweet Caroline” during Boston’s eighth inning

REPORT OF THE TREASURER - 2005 James U. Piper, Treasurer

Page 1 of the financial report reflects the transactions in the operating account of the Section. In addition to the operating account, the Trust Funds operate under the supervision of the Board of Trustees. The operating account generally pays all bills and then requests reimbursement of Trust-related expenses from the Trustees. In 2005, those reimbursements totaled $65,600.29 (line 10). Since the Trust funds are separately maintained, the calculation of the Public Support ratio on page 2 of the Financial Report is incorrect. The correct calculation is on the attachment to the Financial Report.

Although the Section ran a small operating deficit in 2005, this is offset by an increase in outstanding reimbursements due from the Trust accounts. At the end of 2004, $28,410 was owed to the Operating Account by the Trust accounts. At the end of 2005, the amount due was $36,162.

A separate set of books is kept for the Nucleus, and these are maintained on an accrual basis. The financial results presented by the Board of Publications differ from those in the Treasurer’s report because the latter is presented on a cash basis.

The Attorney General of the Commonwealth of Massachusetts requires nonprofit organizations to file annual reports accompanied, in our case, by a review by a CPA. The review of the 2004 financial statements was completed in July, and the report was filed. Copies of forms 990 and 990T for 2004 were sent to the National ACS office.

James U. Piper Treasurer

REPORT OF THE BOARD OF TRUSTEES - 2005 Esther A. H. Hopkins, Joseph A. Lima, Michael E. Strem

The Trustees of the Section for the year 2005 were Esther A. H. Hopkins, Michael Strem and Joseph Lima. We met with our financial consultant, Robert M. Sarly, Senior Vice President at Smith Barney, Inc., held informal meetings, received reports from Smith Barney and from Piper Enterprises and discussed recommendations for the Board as to uses for the Funds in our care in keeping with the wishes of the donors of the funds.

The Trust Funds of the Northeastern Section are in three Trust Accounts and six income accounts. The Trust Accounts are (one)—the Consolidated, comprising the principal amounts of the Richards, the Norris, the Publication, the Permanent, the Hill and a portion of the Brauner trusts, (two)—the Esselen Trust, and (three)—the Levins Trust. To keep the capital ratios constant in the Consolidated Trust, capital amounts withdrawn from it are distributed to the Income accounts in the ratio of their ownership.

184

The Consolidated Account for 2005 had an opening portfolio value of $1,742,524.09. Withdrawals made over the year totaled $50,625.96. The adjusted opening balance was, therefore, $1,691,898.13. The closing balance was $1,695,578.53 for an increase of $3,680.40. This represents a gain of 0.22%. The Consolidated Trust contains money funds, common stocks, closed end funds, preferred stocks, mutual funds, corporate bonds and certificates of deposit. The current yield at year-end was 4.81% and the annualized anticipated income was $81,486.93.

The Esselen Fund, comprising money funds, closed end funds, mutual funds and government bonds, had an opening balance of $480,604.28. $17,451.33 was withdrawn for the expense of the award this year. The adjusted opening value was $463,152.95 and the closing value was $494,216.77. The Levins Fund, comprising money funds, preferred stocks, and mutual funds had an opening portfolio balance of $13,724.81. $626.16 was withdrawn during the year for the prize. The closing portfolio value was $8,094.23. The Brauner Trust “income account” comprised of money funds, common stock and closed end funds had an opening balance of $21,474.02. $1,532.06 was deposited from gifts to the Fund for an adjusted opening balance of $23,006.10. The closing value was $24,327.59 of which $4,169.56 was income and the remainder was Trust principal.

The Hill income account comprising money funds and closed end funds had an opening portfolio value of $8,784.64, received $2,497.06 from the prorated distribution from the Consolidated Account, and withdrew $532.31 for expenses for an adjusted value of $10,749.39. The closing value was $10,904.22. The Norris Award income account, comprising only money funds had an opening portfolio value of $7,713.31 and an adjusted value of $4,009.33 after receiving 29,169.66 from the prorated distribution and withdrawing $32,873.64 for expenses. The closing portfolio value was $4,177.61. The Permanent income account, comprising money funds, common stocks and closed end funds had an opening portfolio value of $48,684.36, received $7,221.66 from the prorated distribution and withdrew $10,087.49 in expenses for an adjusted value of $45,818.53. The closing value of the portfolio was $46,773.32. The Publication income account, comprising money funds, common stocks and closed end funds had an opening portfolio value of $43,817.97, received $4,082.10 from the prorated distribution and withdrew $4,021.09 in expenses for an adjusted value of $43,878.98. The closing value was $44,115.54. The Richards income account, comprising money funds and closed end funds had an opening value of $38,689.85, received $5,990.96 from the capital distribution, withdrew expenses of $7,341.31 for an adjusted value of $37,339.50. The closing value was $39,051.63.

Respectfully submitted,

The Trustees

Esther A.H. Hopkins Michael Strem Joe Lima

185

ANNUAL REPORT Northeastern Section, ACS

APPENDIX 5-A

Programs: NSCRC Connections to Chemistry Undergraduate Environmental Research Symposium

http://www.nesacs.org

186

The Seventh Annual Northeast Student Chemistry Research Conference

NSCRC 2005

Saturday,April 23, 2005

MIT The Ray and Maria Stata Center Building 32 32 Vassar Street Cambridge, MA {click here for map and directions}

Deadlines for submission: April 8, 2005 for oral presentations, April 15, 2005 for poster presentations. Program Schedule:

8:30am - 9:00am Poster Set-Up and Registration, Breakfast

9:00am - 9:15am Welcoming Remarks (Kirsch auditorium, room 123)

9:15am - 9:30am German Exchange Presentation

Will Neeley (MIT) 9:30am - 9:50am Formation of 2-Aminoimidazolone and Urea in DNA as a Consequence of 7,8-Dihydro oxoguanine Oxidation Provides Potent Sources of Point Mutations in Vivo

Sarah Fischer (University of Massachusetts at Lowell) 9:50am - 10:10am Scope and Limitations of the Reaction of Potassium Hyride with Thiones

187

Sarah Chobot (Boston University) 10:10am - 10:30am Characterization of Thioredoxin Systems Via Protein Film Voltammetry

10:30am - 10:50am Coffee Break

Sonia Taktak (Tufts University) 10:50am - 11:10am Olefin epoxidation and aromatic hydroxylation promoted by biomimetic amino-pyridine iron complexes - effect of coordination sphere and nuclearity.

Christopher Gilmore (Boston College) 11:10am - 11:30am The Synthesis of 4(R)-hydroxy-L-proline-glycine Alkene Isostere.

Erin Prestwich (Boston College) 11:30am - 11:50am Amino acid promoted DNA cleavage.

11:50am - 12:30pm Lunch

12:30pm - 1:30pm First Poster Session

1:30pm - 2:30pm Second Poster Session

Keynote Address: Dr. David Walt of Tufts University: 2:30pm - 3:30pm "Optical Sensor Arrays: From Molecular and Cell Biology to Artificial Olfaction".

3:30pm - 3:50pm Awards Presentation

3:50pm - 4:00pm Closing Remarks, Poster Take-Down

This conference is being sponsored by:

188

NSCRC 2005 picture gallery

Lauren Wolf (BU) talks to Rukman DaSilva (Dartmouth) and Liz O'Day (BC) at the poster session

Prof. Catherine Costello looks at attendee's poster

NSYCC officer Sonia Taktak presents the keynote speaker Dr. Walt of Tufts University with a gift

189

Complete Program: Connections to Chemistry ity of Massachusetts Lowell Connections to Chemistry

Burlington High School Burlington, Massachusetts

October 19, 2005

Sponsored by the Northeastern Section of the American Chemical Society

190

The American Chemical Society and The Northeastern Section

The American Chemical Society (ACS) is the largest scientific organization in the world that is devoted to a single discipline –chemistry– with more than 160,000 members at all degree levels. Among its members are teachers that span the entire spectrum of chemical education: high schools, two- and four-year colleges, and research universities. The specific interests of the members of the ACS are reflected in the activities of the 34 technical divisions, such as the divisions of Organic Chemistry, Biological Chemistry, Computers in Chemistry, Chemical Education, and the History of Chemistry.

The membership in the Division of Chemical Education (DivCHED) is open to anyone who has an interest in chemical education, including those who teach chemistry in high schools, community colleges, 4-year colleges and universities; membership also includes chemists in industry, government, and foundations. DivCHED publishes the Journal of Chemical Education, which is a monthly journal for all teachers of chemistry, from K–16 and beyond. In addition, DivCHED offers programs for teachers and students to further enhance the learning of chemistry and the future of the profession. For more information, visit the American Chemical Society website at http://www.acs.org.

The ACS has more than 180 local sections of which the Northeastern Section (NESACS) is one of the largest, with almost 6,000 members, encompassing Eastern Massachusetts and New Hampshire. NESACS holds monthly meetings and offers a wide range of technical and social programs for younger chemists, retirees, and all those in between. The Education Committee of NESACS sponsors programs for high school and college students, and programs for chemistry teachers and others who have an interest in chemical education. For more information, visit the NESACS website at http://www.nesacs.org.

191

Program Schedule

Connections to Chemistry

October 19, 2005 3:30 – 4:00 p.m. Registration and Refreshments Main Lobby, Burlington High School

4:00 – 4:25 p.m. Welcome, Overview, and Review of the Sessions (Auditorium) Ruth Tanner, Chair, Education Committee, NESACS Professor of Chemistry, University of Massachusetts Lowell William Carroll, 2005 President, American Chemical Society

4:30 – 6:10 p.m. Five Simultaneous Workshops in Two Sessions: Session I: 4:30 – 5:15 Session II: 5:25 – 6:10 Workshop A: It’s a small, small World (Room 172) Arthur Watterson, Organic Chemist, Institute for NanoScience and Engineering Technology, University of Massachusetts Lowell

Workshop B: Toying with Chemistry (Room 176) John Mauch, Chemistry Teacher, Braintree High School

Workshop C: Why Don’t You Just Make All the Plastic Alike? (Room 173) William Carroll, Polymer Chemist, Occidental Chemical Corporation

Workshop D: Seeing the Unseeable: Demonstrating with Technology (Room 157) Walter Rohr, Chemistry Teacher, Eastchester High School (NY)

Workshop E: Exploring Nuclear Energy (Room 179) Gilbert Brown, Nuclear Engineer, University of Massachusetts Lowell David Barr, Seabrook Power Station

6:15 – 6:55 p.m. Dinner (High School Cafeteria)

7:00 –7:45 p.m. Address (Lower Library) Do We Have a Future, or What? Wild Guesses What Chemical Education Will Be Like in 2015

Dr. William Carroll, 2005 President, American Chemical Society; and Vice President, Occidental Chemical Corporation, Dallas, Texas

192

Keynote Address

Dr. William Carroll

Dr. William F. Carroll, Jr. holds a B.A. in Chemistry and Physics from DePauw University, Greencastle, IN, an M.S. from Tulane University in New Orleans, and a Ph.D. in Organic Chemistry from Indiana University, Bloomington, IN. Bill started his industry career in 1978 and after a year with Rohm and Haas Company, Bristol, PA, moved to what is now known as Occidental Chemical Corporation. He is currently Vice President, Chlorovinyl Issues for OxyChem and works on public policy issues and communications related to chlorine and PVC. He is also Adjunct Professor of Chemistry at Indiana University, Bloomington, Indiana and teaches polymer chemistry.

Bill is President (2005) of the American Chemical Society, a member of the ACS Budget and Finance Committee, and past chair of its International Activities Committee. He is a Fellow of the Royal Society of Chemistry, a member of the US National Committee for the International Union of Pure and Applied Chemistry, and a member of the Science Advisory Board for DePauw University.

He has been an active member of and chaired various committees for a number of chemistry, plastics, fire protection and recycling organizations. He has served on expert groups commissioned by the United Nations Environmental Program, the State of Florida, and the Oregon Department of Environmental Quality. He received the Vinyl Institute’s Roy T. Gottesman Leadership Award for lifetime achievement in 2000.

He holds two patents, and has over forty publications in the fields of organic electrochemistry, polymer chemistry, combustion chemistry and physics, incineration, plastics recycling and chlorine issues.

Do We Have a Future, or What? Wild Guesses What Chemical Education Will Be Like in 2015

The Chemistry Enterprise-for industry, education and government-in the US is changing. One of my projects as President is called Chemistry Enterprise 2015, wherein members have worked to envision the state of chemistry ten years from now.

This presentation will talk about a few trends but more importantly will engage the audience in dialog about the forces impacting us and where we're going. Complete the sentence: "In 2015, I predict..."

193

National Chemistry Week

Celebrate National Chemistry Week — October 16-22, 2005

National Chemistry Week (NCW) provides an opportunity for your students to share the fun and relevance of chemistry with members of their school and neighborhood communities. It also provides a way for them to share in a nation-wide celebration of Chemistry. Teachers can participate in NCW by holding events that focus on celebrating this year’s theme The Joy of Toys. The October issue of ChemMatters, the ACS magazine that connects students to the exciting chemistry of the everyday world, contains articles and activities that reflect this theme. ChemMatters can be accessed on line at . The October issue of the Journal of Chemical Education also features articles about the chemistry of various toys, and lists numerous resources.

As part of the National Chemistry Week 2005 celebration, the Northeastern Section of the American Chemical Society (NESACS) sponsored a daylong program at Wellesley College on Sunday, October 16, 2005. Chemistry demonstrations and hands-on activities related to The Joy of Toys were featured at the Wellesley Science Center. A special presentation of chemical demonstrations was given by Dr. Bassam Shakhashiri, Professor of Chemistry, at the University of Wisconsin-Madison.

For more information on the National Chemistry Week programs for the Northeastern Section, go to and for the national programs go to .

194

195

Workshop A: It’s a Small SMALL World

Arthur Watterson, Organic Chemist and Director, Institute for NanoScience and Engineering Technology, University of Massachusetts Lowell

It’s a small, small world this nanotechnology. Come and enjoy a trip around the world of technology. Learn really how small is nano, test your nano IQ, learn the difference between fact and fiction, and see what your government is doing about nanotechnology. (http://www.nano.gov/html/edu/eduteach.html).

In this workshop we will explore nanotechnology from its first recorded descriptions to current descriptions, definitions, science and society. For example, the Foresight organization holds an annual conference that includes not only scientific advancements but the social implications as well (http://www.foresight.org/conference2005/index.html).

Resources abound in the literature as a google search of the term “nanotechnology in high school experiments produces 1.21 million citations. One of the major reasons for the exploding interest in nanotechnology is the technology available for analysis of materials, particularly new materials. Instrumentation such as atomic force microscopy has become available to image individual atoms and molecules as well as manipulate them.

Nanotechnology is “taking things that we might use everyday and engineering them at a microscopic level to get different properties or interesting things out of the materials that you wouldn’t get at our scale,” said Marshall Brain, founder of howstuffworks.com. Nanoscale properties are the last frontier in terms of materials properties (http://www.thenewatlantis.com/archive/2/keiper.htm) as there are many examples of properties changing as the particle size of the materials become smaller and smaller. We will demonstrate this concept in a hands on experiment with straws. (http://www.iop.org/EJ/article/0031-9120/30/6/F03/pe4_6_fo3.pdf) It is an example of self-assembly that is the driving force for much of the new materials that are being produced today. We let natural forces do the work of assembling new structures. We can also let nature carry out the synthesis of new materials via nature’s nano factories, enzymes.

Discussions and presentations will include suggestions for nanoscience and nanotechnology experiments that may be readily performed at the high school level along with appropriate references.

At the University of Massachusetts Lowell, we have established a nanomanufacturing center funded by the National Science foundation that is designed to bring the new technology to the market place. This will serve as a regional source of information on nanomanufacturing. (http://www.uml.edu/nano/) The University is also being funded by NSF to introduce nanotechnology into the curriculum.

You will come away from this workshop with lots of resources for nanoscience and nanotechnology and a much- improved appreciation for the fields.

196

Workshop B: Toying with Chemistry

John Mauch, Chemistry Teacher, Braintree High School

Your students may be familiar with some of the toys that will be featured in this workshop, but they probably do not realize how much chemistry is in them. For example, Cartesian divers can be made from many different materials, but plastic polyethylene pipettes and stainless steel hex, will take your students to new levels. Participants will receive a bag of materials to make twenty divers. Included will be, Squidy, Hook, Cartesian helicopters, a whimp tester, & Cartesian basketball, will be just a few of the "Cartesian Diversions". Make these divers and leave them in your classroom for your students to play with. Density and pressure are featured concepts.

Silly putty is another substance familiar to your students. Silly putty is an elastomer, a substance that regains its original shape after being shaped or formed. Silly putty has weak coordinate bonds, which are easily broken. Stretch it fast and it snaps in two, pull more slowly and it stretches quite nicely. Liquid like materials that act like a solid under short-term stress are described as dilatant. Participants will make some silly putty from Elmer’s glue and 20-mule team borax. Samples of student self-designed experiments will be shared as well.

Samples of magic sand will be given to each participant. Magic sand is beach sand coated with minute particles of chemically treated silica. This silica creates a new surface on the sand such that it is non-polar. It is hydrophobic so that when it is poured into water, it doesn't get wet. The air between the grains of sand, when it is immersed in water cannot be forced out, and forms a silvery layer that looks like plastic. The silvery layer is the curved surface of a bubble that surrounds the sand.

Samples of polysnow will be given to each participant, this variation of sodium polyacrylate, produces over 40 times its original volume when water is added to it. It turns a glass of water into a snow-like substance right before your eyes.

Other toys in this workshop will include, Wind tubes, Drinking Birds, Putt Putt steam boats, Fuel cell powered cars, chemical light sticks and spectroscopes, and ghost bubbles. Chemical concepts include electrolysis, chemical reactions, light reactions, line spectra, evaporation, and thermodynamics. Won't you come play with us!!!

197

Workshop C: Why don’t You Just Make All the Plastic Alike?

William Carroll, Organic Chemist, Vice President of Occidental Chemical Corporation, Dallas, Texas

It’s Not Just Plastic—Why Materials are Different and How to Tell Web Resources http://www.teachingplastics.com/9_12/index.html http://www.plasticsresource.com/

Plastics are made from small molecules that are joined together to form chains termed polymers. These long chains entwine like spaghetti in a bowl and the plastics get most of their strength from this entangling.

Many plastics are used for packaging of various domestic goods and supplies. Different plastics go into different kinds of bottles. Different plastics have differing amounts of crystallinity (regular organizational pattern in the solid) that determines transparency or clarity, different resistance to heat for being hot filled, and different resistance to the material that is packaged. Typical packaging uses for the common plastics will be discussed with reasons for the selection of a given plastic for a given application.

In recycling of plastics, there are problems in collection of the materials, but the major difficulty in recycling is the separation of the six commonly used plastics. They can be identified by the resin identification code but they can also be separated by taking advantage of their different densities. Thus, ground up soda bottles, even if there is a mix of plastics, can be separated by flotation.

Resin Code Plastic Use Floats or Sinks? #1 PET strong and lacks clarity Sinks (d=1.4) #2 HDPE rigidity Floats (d=0.94) #3 PVC clarity Sinks (d=1.4) #4 LDPE flexibility Floats (d=0.92) #5 PP hot fill Floats (d=0.91) #6 PS resistance to packaged materials Sinks (d=1.05)

We can use light of various frequencies to distinguish polymers. If further identification of plastic material is needed, it can be accomplished by infrared spectroscopy, x-ray transmission, and ultra-violet-visible-spectroscopy. Some separate on color—we can tell colors apart and so can a colorimeter. Some separate on infrared spectroscopy—different materials have different characteristic bands. We can also separate by x-rays. #3 appears cloudy when x-rays are shone through it. #1 appears clear. This system was originally proved out in the airport using their scanners.

All the bottles above are thermoplastics—they soften when they are heated. When the bottles are made in the first place they are made by softening small plastic beads and melting them together, and forming them into a bottle. After float-sink separation, materials are dried, and remade into pellets. These recycle pellets can be added to new pellets and the recovered, separated material can then be reused by extruding or by blowmolding it into new containers to making new products—pipe, bottles, sheet and other things. Then it can be resold. In most cases you buy recycled material and don’t know it. Laundry bottles are 25% recycled.

198

Workshop D: Seeing the Unseeable: Demonstrating with Technology

Walter Rohr, Chemistry Teacher, formerly of Eastchester High School, New York

With the use of modern technology, such as Vernier’s Logger Pro Software and others, one can add a new repertoire of demonstrations and a heightened level of understanding to existing activities. Instead of telling your students what happens after a demonstration, they can now see for themselves and form their own mental images, using techniques such as fast data collection, data collection integrated with videos, and frame by frame video analysis, teachers can introduce phenomena never seen before that becomes the basis for interesting classroom discussions. Demonstration need not be complicated. The simple act of squeezing a bottle, blowing up a balloon, or throwing a ball in the air may be all that is needed to teach a principle. Long tern studies such as photosynthesis can be reduced to a minute or two by replaying the experiment at higher speeds. While most consider technology expensive, it is not. Innovative activities can be filmed with an inexpensive webcam. Depending upon the probes selected, data collected with the latest interfaces and software could cost as little as a few hundred dollars.

199

Workshop E: Exploring Nuclear Energy

Gilbert Brown, Nuclear Engineer, University of Massachusetts Lowell David Barr, Seabrook Power Station

Nuclear Energy is producing some of the least expensive, cleanest, safest and most reliable electricity in the country. This is made possible by nuclear reactions and in particular, the fission of uranium. Radioactivity (and nuclear stability) is the key to understanding nuclear energy and other nuclear phenomenon and applications. An introduction to nuclear concepts is standard fare in many introductory chemistry textbooks, but is often not covered in busy curriculum or is not leaving students with the idea of just how widely used nuclear energy is around the world (over 400 reactors supplying almost 20% of the world’s electricity) or how ubiquitous nuclear technology is in industry and medicine.

We will summarize the state of nuclear energy in the United States and around the world. Profound gains in productivity have been made during the last several years and more and more environmentalists are coming to recognize the true merits of burning uranium as a source of non- CO2 emitting energy.

In addition we will summarize the fundamental concept of nuclear binding energy and nuclear stability. Radioactivity will be discussed as a natural phenomenon – the world is naturally radioactive. We will perform a half life experiment that can be easily reproduced in class.

The goal of this workshop is to provide instructors with current information about that state of nuclear energy and to provide local contacts for follow up tours of the UMass Lowell Research Reactor and Seabrook Station and for guest lectures for class. We will introduce participants to the American Nuclear Society as an excellent source of nuclear information and for curriculum ideas for presenting nuclear science concepts. In this workshop we will model radioactivity and demonstrate the concept of half-life.

The handouts and concepts for this project are supplied by the American Nuclear Society. Funding is provided to the American Nuclear Society by the U.S. Department of Energy University Programs.

200

Thank You

We gratefully acknowledge the contributions of the following organizations and individuals for their support of the 2005 Connections to Chemistry program. We would like to extend our special thanks to Burlington High School for hosting this program.

Program Conference Committee

Ruth Tanner, Chair, Education Committee, NESACS; University of Massachusetts Lowell Morton Hoffman, Chair, Division of Chemical Education, ACS; Boston University Susan Buta, Chair, Speakers Bureau, NESACS Steve Lantos, Chemistry Faculty, Brookline (MA) High School

Planning and Program Associates

Christine Jaworek, Chair, National Chemistry Week, NESACS; Emmanuel College Peter Nassiff, Past-Chair, NEACT; Head, Science Division, Burlington High School Arthur Fallon, Head, Media Services, Burlington High School Mark Malagodi, Computer Services, Burlington High School Cynthis Kazangian, Director of Food Service, Burlington High School Nancy Spicer, Biochemist, Sepracore, Inc. Martin Isaks, Chemistry Faculty, University of Massachusetts Lowell James Hall, Director of Freshman Laboratories, University of Massachusetts Lowell

Material Assistance

John Moore, Editor, Journal of Chemical Education Betty Moore, Associate Editor, Journal of Chemical Education Lin Morris, Assistant Editor, Journal of Chemical Education Helen Herlocker, Manager, Office of High School Science, ACS, (ChemMatters) Kevin McCue, Editor, ChemMatters, ACS Marilou Cashman, Executive Secretary, NESACS Ron Perkins, Educational Innovations

Publicity Support

New England Association of Chemistry Teachers (NEACT) Massachusetts Association of Science Supervisors (MASS) Science Teachers Area Resources Swap (STARS) The Nucleus (NESACS)

201

Registered Schools

Massachusetts Massachusetts

Archbishop Williams High School Salem High School Auburn High School Sharon High School Belmont High School Somerville High School Bishop Fenwick High School St. Mark's High School Boston Latin Academy The Bromfield School Boston Latin School Walden Street School Bridgewater-Raynham Reg. High School Walnut Hill School Brook Farm Academy Waltham High School Cambridge School of Weston Wellesley High School Concord High School Westborough High School Danvers High School Everett High School Fitchburg State College New Hampshire Fontbonne Academy Framingham High School Franklin Pierce College Gloucester High School John Stark Regional High School Groton Dunstable Reg. High School Laconia Academy Hingham High School Londonderry High School Holliston High School Manchester West High School Hopkinton High School Merrimack High School Hudson High School Nashua High School North King Philip High School Nashua High School South Lawrence Academy Oyster River High School Lawrence High School Pinkerton Academy Lexington High School Portsmouth High School Locke School Wilton-Lyndeboro High School Lowell High School Lynnfield High School Connecticut Malden High School Manchester High School West Branford High School Mansfield High School Fairfield Ludlowe High School Marlborough Middle School The Hotchkiss School Medford High School Media Comm. & Technology High School Natick High School Rhode Island National Plastics Center & Museum Newburyport High School E3-Providence High School Newton Country Day School Central High School North Andover High School North Middlesex Regional High School North Quincy High School Maine North Reading High School Northampton High School Berwick Academy Notre Dame Academy Poland Regional High School Oliver Ames High School Pentucket Regional High School Presentation of Mary Academy Revere High School Registration as of October 13, 2005

202

Environmental Research and Teaching

Fourth Annual Undergraduate Environmental Research Symposium Bridgewater State College Saturday, November 12, 2005 9:00 AM - 3:00 PM John Joseph Moakley Center

Guest Speaker: Dr. John Titus "Environmental Change & Freshwater Ecology: From Organisms to Watersheds" Department of Biological Sciences Binghamton University State University of New York

Symposium Program, Titles and Abstracts

Announcement (PDF Poster) Directions to the Moakley Center Symposium Program BSC Campus Maps Sponsors Contact Information

SPONSORS Bridgewater State College Adrian Tinsley Program for Undergraduate Research Northeastern Section of the American Chemical Society

203

Bridgewater State College will host the Fourth Annual Undergraduate Environmental Research Symposium on Saturday, November 12, 2005. Undergraduate and graduate student research posters (including completed, in progress, and proposed research) in all environmental disciplines from colleges and universities in the Northeastern U.S. are welcome! Over the past three years the Symposium has averaged nearly 100 attendees and 20-30 student poster presentations. We hope that this Symposium will provide an annual forum for discussion of environmental research and concerns particular to the New England region, and open doors to potential research collaborations among the participants.

To help defray costs, a registration fee of $10 will be collected on-site. For additional information or to be added to our email distribution list, please contact the Symposium Coordinators: Tammy DeRamos King, Department of Chemical Sciences ([email protected]), and Don Padgett, Department of Biological Sciences ([email protected]).

Updated November 10, 2005.

204

Environmental Research and Teaching

Fourth Annual Environmental Research Symposium Bridgewater State College Moakley Center Saturday, November 12, 2005

Symposium Program

Poster Titles and Abstracts 2005 Return to Symposium Home Page

PROGRAM

8:30 - 11:00 Registration and poster set up in Moakley Atrium; coffee, juice and light breakfast

9:45 - 10:00 Welcoming Remarks in Moakley Auditorium: Dr. Dana Mohler-Faria, President, Bridgewater State College

10:00 - 10:45 Guest Speaker: Dr. John Titus Department of Biological Sciences Binghamton University State University of New York "Environmental Change & Freshwater Ecology: From Organisms to Watersheds"

11:00 - 12:15 Poster Session I: Boards 1 - 14, Moakley Atrium

12:15 - 12:30 Take down Posters from Session I, put up Session II Posters

12:30 - 1:15 Lunch, Moakley Balcony & Atrium (Informal poster discussions may continue)

1:15 - 2:30 Poster Session II: Boards 15-28, Moakley Atrium

205

206

ANNUAL REPORT Northeastern Section, ACS

APPENDIX 5-A

Programs: NSCRC Connections to Chemistry Undergraduate Environmental Research Symposium

http://www.nesacs.org

207

The Seventh Annual Northeast Student Chemistry Research Conference

NSCRC 2005

Saturday,April 23, 2005

MIT The Ray and Maria Stata Center Building 32 32 Vassar Street Cambridge, MA {click here for map and directions}

Deadlines for submission: April 8, 2005 for oral presentations, April 15, 2005 for poster presentations. Program Schedule:

8:30am - 9:00am Poster Set-Up and Registration, Breakfast

9:00am - 9:15am Welcoming Remarks (Kirsch auditorium, room 123)

9:15am - 9:30am German Exchange Presentation

Will Neeley (MIT) 9:30am - 9:50am Formation of 2-Aminoimidazolone and Urea in DNA as a Consequence of 7,8-Dihydro oxoguanine Oxidation Provides Potent Sources of Point Mutations in Vivo

Sarah Fischer (University of Massachusetts at Lowell) 9:50am - 10:10am Scope and Limitations of the Reaction of Potassium Hyride with Thiones

208

Sarah Chobot (Boston University) 10:10am - 10:30am Characterization of Thioredoxin Systems Via Protein Film Voltammetry

10:30am - 10:50am Coffee Break

Sonia Taktak (Tufts University) 10:50am - 11:10am Olefin epoxidation and aromatic hydroxylation promoted by biomimetic amino-pyridine iron complexes - effect of coordination sphere and nuclearity.

Christopher Gilmore (Boston College) 11:10am - 11:30am The Synthesis of 4(R)-hydroxy-L-proline-glycine Alkene Isostere.

Erin Prestwich (Boston College) 11:30am - 11:50am Amino acid promoted DNA cleavage.

11:50am - 12:30pm Lunch

12:30pm - 1:30pm First Poster Session

1:30pm - 2:30pm Second Poster Session

Keynote Address: Dr. David Walt of Tufts University: 2:30pm - 3:30pm "Optical Sensor Arrays: From Molecular and Cell Biology to Artificial Olfaction".

3:30pm - 3:50pm Awards Presentation

3:50pm - 4:00pm Closing Remarks, Poster Take-Down

This conference is being sponsored by:

209

NSCRC 2005 picture gallery

Lauren Wolf (BU) talks to Rukman DaSilva (Dartmouth) and Liz O'Day (BC) at the poster session

Prof. Catherine Costello looks at attendee's poster

NSYCC officer Sonia Taktak presents the keynote speaker Dr. Walt of Tufts University with a gift

210

Complete Program: Connections to Chemistry ity of Massachusetts Lowell Connections to Chemistry

Burlington High School Burlington, Massachusetts

October 19, 2005

Sponsored by the Northeastern Section of the American Chemical Society

211

The American Chemical Society and The Northeastern Section

The American Chemical Society (ACS) is the largest scientific organization in the world that is devoted to a single discipline –chemistry– with more than 160,000 members at all degree levels. Among its members are teachers that span the entire spectrum of chemical education: high schools, two- and four-year colleges, and research universities. The specific interests of the members of the ACS are reflected in the activities of the 34 technical divisions, such as the divisions of Organic Chemistry, Biological Chemistry, Computers in Chemistry, Chemical Education, and the History of Chemistry.

The membership in the Division of Chemical Education (DivCHED) is open to anyone who has an interest in chemical education, including those who teach chemistry in high schools, community colleges, 4-year colleges and universities; membership also includes chemists in industry, government, and foundations. DivCHED publishes the Journal of Chemical Education, which is a monthly journal for all teachers of chemistry, from K–16 and beyond. In addition, DivCHED offers programs for teachers and students to further enhance the learning of chemistry and the future of the profession. For more information, visit the American Chemical Society website at http://www.acs.org.

The ACS has more than 180 local sections of which the Northeastern Section (NESACS) is one of the largest, with almost 6,000 members, encompassing Eastern Massachusetts and New Hampshire. NESACS holds monthly meetings and offers a wide range of technical and social programs for younger chemists, retirees, and all those in between. The Education Committee of NESACS sponsors programs for high school and college students, and programs for chemistry teachers and others who have an interest in chemical education. For more information, visit the NESACS website at http://www.nesacs.org.

212

Program Schedule

Connections to Chemistry

October 19, 2005 3:30 – 4:00 p.m. Registration and Refreshments Main Lobby, Burlington High School

4:00 – 4:25 p.m. Welcome, Overview, and Review of the Sessions (Auditorium) Ruth Tanner, Chair, Education Committee, NESACS Professor of Chemistry, University of Massachusetts Lowell William Carroll, 2005 President, American Chemical Society

4:30 – 6:10 p.m. Five Simultaneous Workshops in Two Sessions: Session I: 4:30 – 5:15 Session II: 5:25 – 6:10 Workshop A: It’s a small, small World (Room 172) Arthur Watterson, Organic Chemist, Institute for NanoScience and Engineering Technology, University of Massachusetts Lowell

Workshop B: Toying with Chemistry (Room 176) John Mauch, Chemistry Teacher, Braintree High School

Workshop C: Why Don’t You Just Make All the Plastic Alike? (Room 173) William Carroll, Polymer Chemist, Occidental Chemical Corporation

Workshop D: Seeing the Unseeable: Demonstrating with Technology (Room 157) Walter Rohr, Chemistry Teacher, Eastchester High School (NY)

Workshop E: Exploring Nuclear Energy (Room 179) Gilbert Brown, Nuclear Engineer, University of Massachusetts Lowell David Barr, Seabrook Power Station

6:15 – 6:55 p.m. Dinner (High School Cafeteria)

7:00 –7:45 p.m. Address (Lower Library) Do We Have a Future, or What? Wild Guesses What Chemical Education Will Be Like in 2015

Dr. William Carroll, 2005 President, American Chemical Society; and Vice President, Occidental Chemical Corporation, Dallas, Texas

213

Keynote Address

Dr. William Carroll

Dr. William F. Carroll, Jr. holds a B.A. in Chemistry and Physics from DePauw University, Greencastle, IN, an M.S. from Tulane University in New Orleans, and a Ph.D. in Organic Chemistry from Indiana University, Bloomington, IN. Bill started his industry career in 1978 and after a year with Rohm and Haas Company, Bristol, PA, moved to what is now known as Occidental Chemical Corporation. He is currently Vice President, Chlorovinyl Issues for OxyChem and works on public policy issues and communications related to chlorine and PVC. He is also Adjunct Professor of Chemistry at Indiana University, Bloomington, Indiana and teaches polymer chemistry.

Bill is President (2005) of the American Chemical Society, a member of the ACS Budget and Finance Committee, and past chair of its International Activities Committee. He is a Fellow of the Royal Society of Chemistry, a member of the US National Committee for the International Union of Pure and Applied Chemistry, and a member of the Science Advisory Board for DePauw University.

He has been an active member of and chaired various committees for a number of chemistry, plastics, fire protection and recycling organizations. He has served on expert groups commissioned by the United Nations Environmental Program, the State of Florida, and the Oregon Department of Environmental Quality. He received the Vinyl Institute’s Roy T. Gottesman Leadership Award for lifetime achievement in 2000.

He holds two patents, and has over forty publications in the fields of organic electrochemistry, polymer chemistry, combustion chemistry and physics, incineration, plastics recycling and chlorine issues.

Do We Have a Future, or What? Wild Guesses What Chemical Education Will Be Like in 2015

The Chemistry Enterprise-for industry, education and government-in the US is changing. One of my projects as President is called Chemistry Enterprise 2015, wherein members have worked to envision the state of chemistry ten years from now.

This presentation will talk about a few trends but more importantly will engage the audience in dialog about the forces impacting us and where we're going. Complete the sentence: "In 2015, I predict..."

214

National Chemistry Week

Celebrate National Chemistry Week — October 16-22, 2005

National Chemistry Week (NCW) provides an opportunity for your students to share the fun and relevance of chemistry with members of their school and neighborhood communities. It also provides a way for them to share in a nation-wide celebration of Chemistry. Teachers can participate in NCW by holding events that focus on celebrating this year’s theme The Joy of Toys. The October issue of ChemMatters, the ACS magazine that connects students to the exciting chemistry of the everyday world, contains articles and activities that reflect this theme. ChemMatters can be accessed on line at . The October issue of the Journal of Chemical Education also features articles about the chemistry of various toys, and lists numerous resources.

As part of the National Chemistry Week 2005 celebration, the Northeastern Section of the American Chemical Society (NESACS) sponsored a daylong program at Wellesley College on Sunday, October 16, 2005. Chemistry demonstrations and hands-on activities related to The Joy of Toys were featured at the Wellesley Science Center. A special presentation of chemical demonstrations was given by Dr. Bassam Shakhashiri, Professor of Chemistry, at the University of Wisconsin-Madison.

For more information on the National Chemistry Week programs for the Northeastern Section, go to and for the national programs go to .

215

216

Workshop A: It’s a Small SMALL World

Arthur Watterson, Organic Chemist and Director, Institute for NanoScience and Engineering Technology, University of Massachusetts Lowell

It’s a small, small world this nanotechnology. Come and enjoy a trip around the world of technology. Learn really how small is nano, test your nano IQ, learn the difference between fact and fiction, and see what your government is doing about nanotechnology. (http://www.nano.gov/html/edu/eduteach.html).

In this workshop we will explore nanotechnology from its first recorded descriptions to current descriptions, definitions, science and society. For example, the Foresight organization holds an annual conference that includes not only scientific advancements but the social implications as well (http://www.foresight.org/conference2005/index.html).

Resources abound in the literature as a google search of the term “nanotechnology in high school experiments produces 1.21 million citations. One of the major reasons for the exploding interest in nanotechnology is the technology available for analysis of materials, particularly new materials. Instrumentation such as atomic force microscopy has become available to image individual atoms and molecules as well as manipulate them.

Nanotechnology is “taking things that we might use everyday and engineering them at a microscopic level to get different properties or interesting things out of the materials that you wouldn’t get at our scale,” said Marshall Brain, founder of howstuffworks.com. Nanoscale properties are the last frontier in terms of materials properties (http://www.thenewatlantis.com/archive/2/keiper.htm) as there are many examples of properties changing as the particle size of the materials become smaller and smaller. We will demonstrate this concept in a hands on experiment with straws. (http://www.iop.org/EJ/article/0031-9120/30/6/F03/pe4_6_fo3.pdf) It is an example of self-assembly that is the driving force for much of the new materials that are being produced today. We let natural forces do the work of assembling new structures. We can also let nature carry out the synthesis of new materials via nature’s nano factories, enzymes.

Discussions and presentations will include suggestions for nanoscience and nanotechnology experiments that may be readily performed at the high school level along with appropriate references.

At the University of Massachusetts Lowell, we have established a nanomanufacturing center funded by the National Science foundation that is designed to bring the new technology to the market place. This will serve as a regional source of information on nanomanufacturing. (http://www.uml.edu/nano/) The University is also being funded by NSF to introduce nanotechnology into the curriculum.

You will come away from this workshop with lots of resources for nanoscience and nanotechnology and a much- improved appreciation for the fields.

217

Workshop B: Toying with Chemistry

John Mauch, Chemistry Teacher, Braintree High School

Your students may be familiar with some of the toys that will be featured in this workshop, but they probably do not realize how much chemistry is in them. For example, Cartesian divers can be made from many different materials, but plastic polyethylene pipettes and stainless steel hex, will take your students to new levels. Participants will receive a bag of materials to make twenty divers. Included will be, Squidy, Hook, Cartesian helicopters, a whimp tester, & Cartesian basketball, will be just a few of the "Cartesian Diversions". Make these divers and leave them in your classroom for your students to play with. Density and pressure are featured concepts.

Silly putty is another substance familiar to your students. Silly putty is an elastomer, a substance that regains its original shape after being shaped or formed. Silly putty has weak coordinate bonds, which are easily broken. Stretch it fast and it snaps in two, pull more slowly and it stretches quite nicely. Liquid like materials that act like a solid under short-term stress are described as dilatant. Participants will make some silly putty from Elmer’s glue and 20-mule team borax. Samples of student self-designed experiments will be shared as well.

Samples of magic sand will be given to each participant. Magic sand is beach sand coated with minute particles of chemically treated silica. This silica creates a new surface on the sand such that it is non-polar. It is hydrophobic so that when it is poured into water, it doesn't get wet. The air between the grains of sand, when it is immersed in water cannot be forced out, and forms a silvery layer that looks like plastic. The silvery layer is the curved surface of a bubble that surrounds the sand.

Samples of polysnow will be given to each participant, this variation of sodium polyacrylate, produces over 40 times its original volume when water is added to it. It turns a glass of water into a snow-like substance right before your eyes.

Other toys in this workshop will include, Wind tubes, Drinking Birds, Putt Putt steam boats, Fuel cell powered cars, chemical light sticks and spectroscopes, and ghost bubbles. Chemical concepts include electrolysis, chemical reactions, light reactions, line spectra, evaporation, and thermodynamics. Won't you come play with us!!!

218

Workshop C: Why don’t You Just Make All the Plastic Alike?

William Carroll, Organic Chemist, Vice President of Occidental Chemical Corporation, Dallas, Texas

It’s Not Just Plastic—Why Materials are Different and How to Tell Web Resources http://www.teachingplastics.com/9_12/index.html http://www.plasticsresource.com/

Plastics are made from small molecules that are joined together to form chains termed polymers. These long chains entwine like spaghetti in a bowl and the plastics get most of their strength from this entangling.

Many plastics are used for packaging of various domestic goods and supplies. Different plastics go into different kinds of bottles. Different plastics have differing amounts of crystallinity (regular organizational pattern in the solid) that determines transparency or clarity, different resistance to heat for being hot filled, and different resistance to the material that is packaged. Typical packaging uses for the common plastics will be discussed with reasons for the selection of a given plastic for a given application.

In recycling of plastics, there are problems in collection of the materials, but the major difficulty in recycling is the separation of the six commonly used plastics. They can be identified by the resin identification code but they can also be separated by taking advantage of their different densities. Thus, ground up soda bottles, even if there is a mix of plastics, can be separated by flotation.

Resin Code Plastic Use Floats or Sinks? #1 PET strong and lacks clarity Sinks (d=1.4) #2 HDPE rigidity Floats (d=0.94) #3 PVC clarity Sinks (d=1.4) #4 LDPE flexibility Floats (d=0.92) #5 PP hot fill Floats (d=0.91) #6 PS resistance to packaged materials Sinks (d=1.05)

We can use light of various frequencies to distinguish polymers. If further identification of plastic material is needed, it can be accomplished by infrared spectroscopy, x-ray transmission, and ultra-violet-visible-spectroscopy. Some separate on color—we can tell colors apart and so can a colorimeter. Some separate on infrared spectroscopy—different materials have different characteristic bands. We can also separate by x-rays. #3 appears cloudy when x-rays are shone through it. #1 appears clear. This system was originally proved out in the airport using their scanners.

All the bottles above are thermoplastics—they soften when they are heated. When the bottles are made in the first place they are made by softening small plastic beads and melting them together, and forming them into a bottle. After float-sink separation, materials are dried, and remade into pellets. These recycle pellets can be added to new pellets and the recovered, separated material can then be reused by extruding or by blowmolding it into new containers to making new products—pipe, bottles, sheet and other things. Then it can be resold. In most cases you buy recycled material and don’t know it. Laundry bottles are 25% recycled.

219

Workshop D: Seeing the Unseeable: Demonstrating with Technology

Walter Rohr, Chemistry Teacher, formerly of Eastchester High School, New York

With the use of modern technology, such as Vernier’s Logger Pro Software and others, one can add a new repertoire of demonstrations and a heightened level of understanding to existing activities. Instead of telling your students what happens after a demonstration, they can now see for themselves and form their own mental images, using techniques such as fast data collection, data collection integrated with videos, and frame by frame video analysis, teachers can introduce phenomena never seen before that becomes the basis for interesting classroom discussions. Demonstration need not be complicated. The simple act of squeezing a bottle, blowing up a balloon, or throwing a ball in the air may be all that is needed to teach a principle. Long tern studies such as photosynthesis can be reduced to a minute or two by replaying the experiment at higher speeds. While most consider technology expensive, it is not. Innovative activities can be filmed with an inexpensive webcam. Depending upon the probes selected, data collected with the latest interfaces and software could cost as little as a few hundred dollars.

220

Workshop E: Exploring Nuclear Energy

Gilbert Brown, Nuclear Engineer, University of Massachusetts Lowell David Barr, Seabrook Power Station

Nuclear Energy is producing some of the least expensive, cleanest, safest and most reliable electricity in the country. This is made possible by nuclear reactions and in particular, the fission of uranium. Radioactivity (and nuclear stability) is the key to understanding nuclear energy and other nuclear phenomenon and applications. An introduction to nuclear concepts is standard fare in many introductory chemistry textbooks, but is often not covered in busy curriculum or is not leaving students with the idea of just how widely used nuclear energy is around the world (over 400 reactors supplying almost 20% of the world’s electricity) or how ubiquitous nuclear technology is in industry and medicine.

We will summarize the state of nuclear energy in the United States and around the world. Profound gains in productivity have been made during the last several years and more and more environmentalists are coming to recognize the true merits of burning uranium as a source of non- CO2 emitting energy.

In addition we will summarize the fundamental concept of nuclear binding energy and nuclear stability. Radioactivity will be discussed as a natural phenomenon – the world is naturally radioactive. We will perform a half life experiment that can be easily reproduced in class.

The goal of this workshop is to provide instructors with current information about that state of nuclear energy and to provide local contacts for follow up tours of the UMass Lowell Research Reactor and Seabrook Station and for guest lectures for class. We will introduce participants to the American Nuclear Society as an excellent source of nuclear information and for curriculum ideas for presenting nuclear science concepts. In this workshop we will model radioactivity and demonstrate the concept of half-life.

The handouts and concepts for this project are supplied by the American Nuclear Society. Funding is provided to the American Nuclear Society by the U.S. Department of Energy University Programs.

221

Thank You

We gratefully acknowledge the contributions of the following organizations and individuals for their support of the 2005 Connections to Chemistry program. We would like to extend our special thanks to Burlington High School for hosting this program.

Program Conference Committee

Ruth Tanner, Chair, Education Committee, NESACS; University of Massachusetts Lowell Morton Hoffman, Chair, Division of Chemical Education, ACS; Boston University Susan Buta, Chair, Speakers Bureau, NESACS Steve Lantos, Chemistry Faculty, Brookline (MA) High School

Planning and Program Associates

Christine Jaworek, Chair, National Chemistry Week, NESACS; Emmanuel College Peter Nassiff, Past-Chair, NEACT; Head, Science Division, Burlington High School Arthur Fallon, Head, Media Services, Burlington High School Mark Malagodi, Computer Services, Burlington High School Cynthis Kazangian, Director of Food Service, Burlington High School Nancy Spicer, Biochemist, Sepracore, Inc. Martin Isaks, Chemistry Faculty, University of Massachusetts Lowell James Hall, Director of Freshman Laboratories, University of Massachusetts Lowell

Material Assistance

John Moore, Editor, Journal of Chemical Education Betty Moore, Associate Editor, Journal of Chemical Education Lin Morris, Assistant Editor, Journal of Chemical Education Helen Herlocker, Manager, Office of High School Science, ACS, (ChemMatters) Kevin McCue, Editor, ChemMatters, ACS Marilou Cashman, Executive Secretary, NESACS Ron Perkins, Educational Innovations

Publicity Support

New England Association of Chemistry Teachers (NEACT) Massachusetts Association of Science Supervisors (MASS) Science Teachers Area Resources Swap (STARS) The Nucleus (NESACS)

222

Registered Schools

Massachusetts Massachusetts

Archbishop Williams High School Salem High School Auburn High School Sharon High School Belmont High School Somerville High School Bishop Fenwick High School St. Mark's High School Boston Latin Academy The Bromfield School Boston Latin School Walden Street School Bridgewater-Raynham Reg. High School Walnut Hill School Brook Farm Academy Waltham High School Cambridge School of Weston Wellesley High School Concord High School Westborough High School Danvers High School Everett High School Fitchburg State College New Hampshire Fontbonne Academy Framingham High School Franklin Pierce College Gloucester High School John Stark Regional High School Groton Dunstable Reg. High School Laconia Academy Hingham High School Londonderry High School Holliston High School Manchester West High School Hopkinton High School Merrimack High School Hudson High School Nashua High School North King Philip High School Nashua High School South Lawrence Academy Oyster River High School Lawrence High School Pinkerton Academy Lexington High School Portsmouth High School Locke School Wilton-Lyndeboro High School Lowell High School Lynnfield High School Connecticut Malden High School Manchester High School West Branford High School Mansfield High School Fairfield Ludlowe High School Marlborough Middle School The Hotchkiss School Medford High School Media Comm. & Technology High School Natick High School Rhode Island National Plastics Center & Museum Newburyport High School E3-Providence High School Newton Country Day School Central High School North Andover High School North Middlesex Regional High School North Quincy High School Maine North Reading High School Northampton High School Berwick Academy Notre Dame Academy Poland Regional High School Oliver Ames High School Pentucket Regional High School Presentation of Mary Academy Revere High School Registration as of October 13, 2005

223

Environmental Research and Teaching

Fourth Annual Undergraduate Environmental Research Symposium Bridgewater State College Saturday, November 12, 2005 9:00 AM - 3:00 PM John Joseph Moakley Center

Guest Speaker: Dr. John Titus "Environmental Change & Freshwater Ecology: From Organisms to Watersheds" Department of Biological Sciences Binghamton University State University of New York

Symposium Program, Titles and Abstracts

Announcement (PDF Poster) Directions to the Moakley Center Symposium Program BSC Campus Maps Sponsors Contact Information

SPONSORS Bridgewater State College Adrian Tinsley Program for Undergraduate Research Northeastern Section of the American Chemical Society

224

Bridgewater State College will host the Fourth Annual Undergraduate Environmental Research Symposium on Saturday, November 12, 2005. Undergraduate and graduate student research posters (including completed, in progress, and proposed research) in all environmental disciplines from colleges and universities in the Northeastern U.S. are welcome! Over the past three years the Symposium has averaged nearly 100 attendees and 20-30 student poster presentations. We hope that this Symposium will provide an annual forum for discussion of environmental research and concerns particular to the New England region, and open doors to potential research collaborations among the participants.

To help defray costs, a registration fee of $10 will be collected on-site. For additional information or to be added to our email distribution list, please contact the Symposium Coordinators: Tammy DeRamos King, Department of Chemical Sciences ([email protected]), and Don Padgett, Department of Biological Sciences ([email protected]).

Updated November 10, 2005.

225

Environmental Research and Teaching

Fourth Annual Environmental Research Symposium Bridgewater State College Moakley Center Saturday, November 12, 2005

Symposium Program

Poster Titles and Abstracts 2005 Return to Symposium Home Page

PROGRAM

8:30 - 11:00 Registration and poster set up in Moakley Atrium; coffee, juice and light breakfast

9:45 - 10:00 Welcoming Remarks in Moakley Auditorium: Dr. Dana Mohler-Faria, President, Bridgewater State College

10:00 - 10:45 Guest Speaker: Dr. John Titus Department of Biological Sciences Binghamton University State University of New York "Environmental Change & Freshwater Ecology: From Organisms to Watersheds"

11:00 - 12:15 Poster Session I: Boards 1 - 14, Moakley Atrium

12:15 - 12:30 Take down Posters from Session I, put up Session II Posters

12:30 - 1:15 Lunch, Moakley Balcony & Atrium (Informal poster discussions may continue)

1:15 - 2:30 Poster Session II: Boards 15-28, Moakley Atrium

226

ANNUAL REPORT Northeastern Section, ACS

APPENDIX 6 YOUNGER CHEMISTS COMMITTEE REPORT

http://www.nesacs.org

227

APPENDIX 6 – Younger Chemists Committee Report Submitted by Ivan V. Korendovych, Chair NSYCC 2005 (follows formas prescribed by ACS)

I. Overall Evaluation

Followed by expansion in 2004 the Northeastern Section Younger Chemists Committee (NSYCC) in 2005 focused on improving organization of several new events introduced in previous years to lay solid foundation for future expansion.

We have also much improved organization of our new event, Northeast Student Chemistry Career Fair (NSCCF), which this year drew ~120 younger chemists. We have requested a pre-registration with returnable deposit, which worked exceptionally well. This year we held thee workshops run concurrently with the job fair this year. This format proved to be very good resulting in better time management – the attendees could easily come to the resume review sessions, visit company booths and learn more about interviewing techniques based on their own schedule. It also helped to distribute workload for the ACS Career Services representatives over time. Several of the attendees came away from the event with job interviews and offers (see below). In fact demand for resume review and mock interview exceeded our expectations and even 4 ACS Career Services representatives had to work at full capacity to help younger chemists improve their resumes. In 2006 we plan to get more ACS career representative for our event.

We have also significantly improved the number and quality of our socially events. The approach we took this year was not only to organize our own events but actively collaborate with other committees of the local section as well as organizations not associated with NESACS directly (such as Graduate Women in Science). This allowed us to reach more people interested in our activities.

This year NSCRC moved to a different location for the first time in seven years. The Ray and Maria Stata Center at MIT provided exceptional facilities for the conference at a lower price than BU. It also helped to attract new students. The NSYCC met its goals this year in the planning of the NSCRC. NSCRC 2005 was a great success in terms of attracting new students and improving organization.

We have decreased our spending: we were able to save $2000 with the same or improved quality of our events. The have also increased committee membership. As of the writing of this report, the YCC has 189 members on its mailing list - a significant improvement over 2004. Our successful website has also seen approximately 3000 hits in the past year. Happily, our goals for 2005 for improving organization after recent expansion were met.

II. Officers and Members

The Annual Report is submitted by the NSYCC Chair each year.

NSYCC Officers

Ivan Korendovych –Chair Department of Chemistry Tufts University 62 Talbot Ave., Medford, MA 02155 korendovych[at]nsycc.org (617)627-5745

228

Lauren K. Wolf – Immediate Past Chair Department of Chemistry Boston University 590 Commonwealth Ave., Boston, MA 02215 lkwolf[at]chem.bu.edu (617)353-3241

Sonia Taktak – Treasurer Department of Chemistry Tufts University 62 Talbot Ave., Medford, MA 02155 sonia.taktak[at]nsycc.org (617)627-5745

Aida Herrera – Career Chair Department of Biological Engineering Massachusetts Institute of Technology 77 Massachusetts Ave., Cambridge, MA 02139 herrera9[at]mit.edu (617)253-5772

Viatcheslav Azev - Webmaster Department of Chemistry Tufts University 62 Talbot Ave., Medford, MA 02155 webmaster[at]nsycc.org (617)627-2042

YCC Mentors

Dr. Amy Tapper – Past YCC Chair Genzyme Drug Discovery and Development 153 Second Ave. Waltham, MA 02451 amy.tapper[at]genzyme.com (781)434-3518

Dr. Michael Strem – Chair of German Exchange Steering Committee Strem Chemicals, Inc. mstrem[at]strem.com

Dr. Ruth Tanner – Chair of NESACS Education Committee University of Massachusetts - Lowell Ruth_Tanner[at]uml.edu

Northeast Student Chemistry Research Conference (NSCRC) 2005 Subcommittee Chair:

Iavn V. Korendovych, Tufts University korendovych[at]nsycc.org

229

Webmaster:

Viatcheslav Azev, Tufts University webmaster[at]nsycc.org

Program and Printing:

Sonia Taktak, Tufts University sonia.taktak[at]nsycc.org Viatcheslav Azev, Tufts University webmaster[at]nsycc.org

Gifts and Journals:

Ivan Korendovych Tufts University korendovych[at]nsycc.org Matthew Aernecke, Tufts University matthew.aernecke[at]tufts.edu

Advertisement:

Lauren Wolf Boston University lkwolf[at]chem.bu.edu Leann Williams, Boston University williaml[at]mtholyoke.edu

Set-up and Arrangements:

Aida Herrera, MIT herrera9[at]mit.edu Leann Williams, Boston University williaml[at]mtholyoke.edu Laila Dafik, Tufts University Laila.dafik[at]tufts.edu Nkeng Asong, Tufts University nkengafeh.asong[at]tufts.edu

III. Activities

Schedules, photographs, and detailed information about each of this year’s activities are available on the new NSYCC website, www.nsycc.org.

Career Symposium 2005: Making the Transition from School to a Career: Experiences and Advice (March 10, 2005)

The annual YCC Career Symposium was held on March 10, 2005 from 3:30-5:30pm prior to the NESACS monthly meeting at Brookline Holiday Inn. This year, the YCC concentrated on the importance of transition from school to a career, the difficulties that have to be overcome, skills that needs to be developed. Speakers at the event represented academic, industrial and governmental jobs.

This year’s speakers were Dr. Nora Conlon of the EPA, Dr. Alexander Kolchinski of Pharm-Eco, Prof. Oleg Ozerov of Brandeis University, Dr. Mark Charest of Novartis.

Each of these speakers shared their personal career experiences and answered questions from the attending students. The event was followed by a social hour where student could ask presenters more questions and network. Approximately 30 younger chemists attended the event.

NESACS monthly meeting following the event featured a career talk. This year keynote speaker was Dr. John Fetzer of Fetzpahs Consulting an author of ‘Career Management for Chemists’. The title of the presentation was ‘Chemistry as a Soft Science’." Copies of Dr. Fetzer’s book on career management were raffled off to younger chemist attendees.

230

This was a very successful event in terms of attracting new members to NSYCC. This year we have plans to combine the Career Symposium with the Career Fair. We believe that this would be beneficial for both events.

Fifth Annual NESACS-YCC/GDCh-JCF Exchange Program (April 3-10)

This year's week-long exchange between the Gesellschaft Deutscher Chemiker-Jungchemikerforum (German Chemical Society - Younger Chemists Committee) and the Northeastern Section Younger Chemists Committee, held during the week of April 3, was a great success. Ten graduate and two undergraduate student from colleges and universities in the Boston area (Harvard, MIT, BC, BU, Tufts, Dartmouth College, University of New Hampshire) have traveled to Germany to participate in the 5th NESACS/GDCh exchange program. German Chemical Society (GDCH) as well it’s Younger Chemists Committee organized the program for students which is presented below.

Saturday, Apr 2, 2005 • Departure from Boston Sunday, Apr 3, 2005 • Arrival to Berlin, welcome by members of the organizing committee of JCF Berlin • Dinner at ‘Zur Letzten Instanz’, the oldest restaurant in Berlin • Monday, Apr 4, 2005 • Guided tour of Berlin • Visit of Technical University of Berlin • Welcome address by Prof. Christopher van Wuleen, Chair of the local section of GDCh Tuesday, Apr 5, 2005 • Visit of Schering, tour the facility, lectures of pharmaceutical research, product development, application process in European companies. Wednesday, Apr 6, 2005 • Visit of Potsdam • Tour of Chemistry Department in the University of Potsdam, tour of the Max Planck Institute of Colloids and Interfaces • Tour of Castle Sanssoussi • Welcome party of the Young Scientists Conference on Chemistry (JCF Spring symposium) at Humboldt University Thursday, Apr 7, 2005 • Oral and poster sessions at JCF Spring symposium • Champagne reception in the evening Friday, Apr 8, 2005 • Oral and poster sessions at JCF Spring symposium • Conference dinner/party Saturday, Apr 9, 2005 • Morning oral research presentations at JCF Spring symposium • Poster session in the afternoon • Closing ceremony, presentation of awards • Farewell dinner in downtown Berlin Sunday, Apr 10, 2005 • Arrival to Boston

231

The students that participated in the program were selected by a steering committee (Dr. Amy Tapper, Dr. Michael Strem, Lauren K. Wolf, Dr. Ruth Tanner, Dr. Morton Hoffmann, Sonia Taktak, Aida Herrera) in a two step process that consisted of application screening followed by an interview. High quality of work presented by the students from the US has been acknowledged by first prize for oral presentation. Sarah Chobot, a graduating senior at Boston University who is doing research with Professor Sean Elliiott, was awarded the prize for the best oral presentation entitled "Electrochemical Studies of Thioredoxin and Thioredoxin Reductase - Gaining Insight into Molecular Mechanisms Affecting Oxidative Stress."at the 2005 Frühjahrssymposium of the Jungchemikerformum (JCF) of the Gesellschaft Deutscher Chemiker (GDCh) that was held in Berlin, Germany, April 7-9. Sarah's prize consists of a cash award of 250 euros (~$325) and a flight ticket to attend any scientific meeting in the world during the next year.

Oral presentations were also made by Pia Lopez (Schrock), M.I.T. (graduate student); Will Neeley (Essigmann), M.I.T. (graduate student); Alex Taylor (Schreiber), Harvard University (graduate student). Poster presentations were made by Liz O'Day (Kantrowitz), Boston College (undergraduate student); Rukman De Silva (Kull), Dartmouth College (graduate student); Tim Gay (Tullius), Boston University (graduate student); Ivan Korendovych (Rybak-Akimova), Tufts University (graduate student); Xiaoguang Lei (Porco) Boston University (graduate student); Liz Vogel (Imperiali), M.I.T. (graduate student); Dan Kennedy (Planalp), University of New Hampshire (graduate student); Amritanshu Sinha (Schrock), M.I.T. (graduate student). A poster presentation was also made by Lauren Wolf (Georgiadis), Boston University (graduate student). A poster on the NESACS educational programs was also presented by Morton Hoffman (Boston University), Ruth Tanner (University of Massachusetts Lowell), Mike Strem (Strem Chemicals, Inc.), Amy Tapper (Peptimmune, Inc.), and Lauren Wolf.

The meeting afforded the opportunity for the organizers of the NESACS-YCC and the GDCh-JCF to meet and make plans for the program beyond this exchange, which has been an annual event since 2001. Morton Hoffman, Chair of the ACS Division of Chemical Education, met with his counterpart of the GDCh (Prof. Franz-Peter Montfors, Universität Breman) to plan cooperative educational programs.

At the farewell dinner for the NESACS-YCC delegation last Saturday night in Berlin, Prof. Henning Hopf, President of the Gesellschaft Deutscher Chemiker (GDCh) presented Mike Strem with the Golden GDCh Pin for his work in promoting the cooperation between the GDCh and the ACS. As a member of the ACS Board of Directors in 1998, Mike was instrumental in the founding of the German-American Frontiers of Chemistry series of symposia, which has now been expanded to include the Royal Society of Chemistry of the United Kingdom in a Trans-Atlantic Frontiers series. Mike was the initial driving force in the establishment of the exchange of young chemists between the GDCh and NESACS, and has been a member of the GDCh since 1991.

The Golden Pin was established by GDCh in 1995 to recognize members and non-members who have rendered outstanding service to chemistry and the chemical society. Mike is the third person to receive the Golden Pin; previous awardees are Prof. Rolf Sammet, the former CEO of Hoechst, and Prof. Wilhelm Fresenius, the former President of the Fresenius Institute.

Northeast Student Chemistry Career Fair, NSCCF (April 23)

2nd annual NSCCF held in Brookline Holiday Inn on March 31, 2005 was a continuation of highly successful Career Fair held last year. The four-hour program constitutes a set of workshops on resume writing and interviewing, resume review as well as the career fair itself. All the parts of the program were held simultaneously.

232

The workshops were hosted by ACS Career Services coordinated by Dr. Daniel Eustace. Mr. Eustace engaged the workshop-attending students in discussion about searching for a job and even held a mock interview to illustrate good and bad interviewing behavior. ACS Career Services booklets and materials were also provided to all attendees. Representatives from 9 regional companies made themselves available for greeting and discussing employment with ~120 attending younger chemists. Companies that attended include Strem Chemicals, Inc., Merck, Novartis Institutes for Biomedical Research, Genzyme, Wyeth, Sigma-RBI, ArQule, Amgen, and the Graduate Women in Science. Many beneficial contacts were made through the Fair. One representative from Wyeth said, "Very successful event, we have collected fewer resumes from bigger career fairs. Looking forward to another job fair next year!". Results of a survey handed in to the participants of the Career Fair were very positive.

Northeast Student Chemistry Research Conference, NSCRC (April 23, 2005)

The Seventh Annual NSCRC took place at the Massachusetts Institute of Technology on Saturday, April 23, 2005. The event, located in the Ray and Maria Stata Center, attracted approximately 60 participants from schools in the Boston area. The event featured 6 graduate/undergraduate oral presentations and 39 poster presentations. This year, we had 8 judges at the NSCRC who walked around and questioned students about their posters and research. Among these were Dr. David Walt, Dr. Cassandra Celatka, Dr. Sean Eliott, Dr. Rosina Geogriadis, Dr. Ruth Tanner. Awards were then given out to the students for the best oral and poster presentations.Cash prizes donated by Strem Chemicals, Graduate Women in Science as well as book gift certificates donated by Springer were awarded to the best graduate and undergraduate presentations.

These awards were as follows:

Best oral presentation, sponsored by Strem Chemicals

Sarah E. Chobot (Boston University) ”Characterization of Thioredoxin Systems Via Protein Film Voltammetry”

Best graduate poster presentation, sponsored by Springer

Peter Rye (MIT) “The Very Short Patch Repair Pathway in E. coli Generates Excision Tracts that are Narrowly Distributed in Length With the Highest Frequency at Three Deoxynucleotides”

Best undergraduate poster presentations, sponsored by Springer

Elizabeth O’Day (Boston College) ”Design and Synthesis of Aspartate Transcarbamoylase Inhibitor Compounds”

Graduate Women in Science Award Lourdes Pia H. Lopes (MIT) “Synthesis and Reactivity of Dimers that Contain Unbridged W(IV)/W(IV) Double Bonds”

In addition, the Brauner Undergraduate Book Award, sponsored by the Education Committee of NESACS, was presented by Dr. Ruth Tanner of UMass-Lowell. The award went to an undergraduate student who gave a poster presentation at the conference:

Maryann E. Racine (MIT)

233

”Fluorescent Sensors for Hg(II) in Aqueous Solution”

A slideshow about the NESACS-YCC/GDCh-JCF German-Exchange Program and 2005 Trip to Berlin and Potsdam was given by 2 of the 12 American participants in this year’s exchange. The presentation featured pictures from the trip itself and information on how students in the area can get involved in the exchange program in 2006.

The keynote address, entitled ”Optical Sensor Arrays: From Molecular and Cell Biology to Artificial Olfaction” was presented by Dr. David R. Walt of Tufts University. To show appreciation to Dr. Walt for giving the keynote address, the NSCRC committee presented him with a desk clock engraved with the name and date of the conference.

This year NSCRC moved to a different location for the first time in seven years. The Ray and Maria Stata Center at MIT provided exceptional facilities for the conference at a lower price than BU. It also helped to attract new students. The NSYCC met its goals this year in the planning of the NSCRC. NSCRC 2005 was a great success in terms of attracting new students and improving organization. In order to achieve the increase in attendance, we would also like to organize a more professional advertising campaign next year. In addition, we would like to obtain financial support from area companies to sponsor cash prizes for student posters and talks. We would also like to further increase the amount of cash prizes awarded.

Chair’s Second Social and Networking Event (November 10, 2005)

YCC and WCC co-sponsored Chair’s Second Social and Networking Event held at the Cambridge Brewing Company. Chemists from the Boston area were invited to beer’s tasting sponsored by Dishman Pharmaceuticals and Chemicals ltd. Attendees had a chance to learn more about beer production and food chemistry and try different kinds of beers immediately after learning about different technologies. Dinner immediately followed the beer tasting.

MIT Museum Tour (December 6th, 2005)

This event was organized by local chapter of GWIS (Graduate Women in Science) was held on December 6th. Approximately 15 attendees of the event enjoyed the tour of MIT museum given by Deborah Douglas, Curator of Science. After the tour Dr. Douglas gave a career profile presentation and talked about museum history. A social hour followed the event.

NSYCC Bowling Social (December 13th, 2005)

NSYCC bowling social took place in Sacco’s Bowling Haven (Davis Sq.) on December 13th. The event went very well, younger chemists from the area had a chance to interact in relaxed atmosphere. Unfortunately, due to the cold weather spell we had only 15 people attending the event. However, the event proved to be very successful – most attendees stayed till the end and expressed interest in attending such bowling events in the future. Next year we are planning to organize a bowling tournament for younger chemists from the area.

Next year, we would like to plan more networking events such as brewery tours and bowling outings.

IV. Budget

February Career Symposium 300$ First Northeast Student Chemistry Career Fair 4200$ The 6th annual NSCRC (co-sponsored by Education Committee) 3000$

234

Website (www.nsycc.org) Address Maintenance 100$ Networking Events 400$

Total Expenses 8000$

This year, the YCC collected $5 registration fees for the NSCRC. We also charged the companies participating in the Career Fair $500 each for their booth space. This offset the costs of these events. The remainder of all funds was received from the Northeastern Section of the American Chemical Society (NESACS).

V. Future Plans

The NSYCC has begun organization of our 3rd annual Career Symposium, to be held April 21, 2006 at the Brookline Holiday Inn. This year we will combine the Career Fair with the Career Symposium in order to improve both events. With what we believe is the optimal organizational scheme, we’ll direct our efforts on better advertisement and getting more companies to attend the fair.

We have also selected the students to participate in the 6th annual exchange between the NESACS-YCC and the GDCh-JCF. This year, we are sending 12 students and 2 representatives to Konstanz during the week of March 12, 2006. Applications were accepted and analyzed during November and December 2005. The selected students were notified and plane tickets have been purchased. The students will once again participate in the German student research conference, the Fruhjahrssymposium. They will also be visiting a Max-Planck-Institute as well as universities in the Konstanz area.

Plans for the 8th annual NSCRC are underway. This year, the conference will be again held at the Massachusetts Institute of Technology on April 22, 2006.

Beyond April 2006, we plan to have a summer networking event and organize our own National Chemistry Week event. We sent representatives to the NCW events organized by NESACS this year to get ideas for the future. Plans for this will begin after April. Our major goal for 2006 is to foster more interest in subcommittees within the NSYCC. We will need new officers and volunteers to plan events in the new future if we continue to expand. We also want to continue advertising the organization by printing promotional materials such as logo pens and notepads.

235

ANNUAL REPORT Northeastern Section, ACS

PART III

ANNUAL FINANCIAL REPORT

http://www.nesacs.org

236

PART III - 2005 ANNUAL FINANCIAL REPORT Section Northeastern ACS Group Exemption number is 0945

A -- Statement of Revenues and Expenses Operating Funds Maps to IRS Form 990E-Z Line # Amount for Line

(1) Annual ACS allotment (1) $29,859.90 3 Subtotals

(2) New member commissions (2) $75.00 1 (3) Donations, contributions (3) $18,405.50 1

(3a) Bequests and/or trusts (list amount separately from line 3) (3a) $0.00 1

(4) Rebate from ACS for Councilor travel expenses (4) $17,768.79 1 $36,249.29 (5) Program revenue (includes newsletters, short courses, lecture series, (5) $53,093.50 2 $53,093.50 national or regional meetings, etc.)

(6) Local Section dues, affiliate dues (6) $55,334.83 3 $85,194.73

(7) Interest, dividends (7) $194.01 4 $194.01

(8) Special Events and activities (describe and itemize in an attachment; the purpose of these is to raise funds that are other than contributions to finance exempt activities. Include events such as dinner dances, raffles, bingo games, etc.)

(8a) Gross revenue (not including $______of contributions reported on line 3) (8a) $0.00 6a $0.00

(8b) Less: direct expenses other than fundraising expenses (8b) $0.00 6b $0.00

(8c) Net income (or loss) from special events and activities (line 8a less line 8b) (8c) $0.00 6c $0.00

(9) Meals (include total meals revenue) (9) $7,345.00 8

(10) Other revenue (describe and itemize) (10) $65,600.29 8 $72,945.29

(11) Total Revenues (add lines 1 through 7 and 8c through 10) (11) $247,676.82 will equal line 9 excluding realized Expenses capital gains(losses)

(12) Subsidies to subsections, topical groups, or affiliate groups (12) $252.79 10

(13) Awards, scholarships, grants, etc. (13) $34,100.00 10 $34,352.79

(14) Administrative expenses (not including postage, printing, and shipping) (14a) Salaries, other compensation (14a) $0.00 12 $0.00

(14b) Professional fees and payments to independent contractors (14b) $34,668.89 13 $34,668.89

(14c) Occupancy, rent, utilities, and maintenance (14c) $985.01 14 $985.01

(14d) Total administrative expenses (add lines 14a through 14c) (14d) $35,653.90

(15) Printing, publications, newsletters, meeting announcements, postage, (15) $57,455.29 15 $57,455.29 and shipping

(16) Local meetings (include speakers’ expenses) (16) $46,503.33 16

(17) Meals (include total meal expenses) (17) $49,632.96 16

(18) Travel subsidies to Councilors (18) $24,157.84 16

(19) Travel subsidy and fee for Local Section Leadership Conference (19) $1,052.20 16

(20) Other expenses (describe and itemize) (20) $0.00 16 $121,346.33

(21) Total Expenses (add lines 12, 13, and 14d through 20) (21) $248,808.31 will equal line 17 237 (22) EXCESS (DEFICIT) (Line 11 less line 21) (22) -$1,131.49 will equal line 18 excluding capital gains (losses)

Please use this space to explain any "other" revenues or expenses.

Line 10 Other Income: Transfers from Trust Accounts - 65,600.29

B – Balance Sheet as of 12/31/05

(23) Investments (estimated current market value of stocks and bonds) (23) $2,286,833.79 22

Of the amount cited in line 23, indicate how much is restricted by external donor stipulation for uses such as awards funds, building funds, etc. List individual accounts, if possible. (23a) Attached Fund (23a)

(23b) Fund (23b)

(23c) Fund (23c)

(23d) Fund (23d)

Total Restricted Funds (add lines 23a, 23b, 23c, 23d) $2,321,456.00

(24) CDs, Money Markets (24) $81,395.46 22

(25) Cash on hand (passbook savings and checkbook) (25) $20,120.78 22 $2,388,350.03

(26) Other assets (describe and itemize) (26) $0.00 24 $0.00

(27) Total Assets (add lines 23, 24, 25 and 26) (27) $2,388,350.03 25 $2,388,350.03

(28) Average interest earned on assets (%): ______4.85%

(29) Liabilities, if any (29) $0.00 26 $0.00

(30) Net assets, 12/31/05 (line 27 less line 29) (30) $2,388,350.03 27 $2,388,350.03

(31) Last Year's Net assets, 12/31/04(line 30, 2001 report) (31) $2,428,200.12 19 $2,428,200.12

(32) EXCESS (DEFICIT) (line 30 less line 31) (32) -$39,850.09

(33) EXCESS (DEFICIT) from line 22 (33) -$1,131.49 will equal line 13

(On a separate attachment, explain any differences between lines 22 and 32)

Public Support Test or Reason for Non-Private Foundation Status. Local sections must normally receive more than 33 1/3% of its support donations from the general public and not more than 33 1/3% of its support from investment income. NOTE: A section that fails the test for 2 consecutive years loses its public charity status and becomes a private foundation.

Public Support Ratio = 99.9% PASS Gifts, Grants, Contributions, Membership Dues & Exempt Function Revenues = Line (1+2+3+4+5+6+9+10) * Gifts, Grants, Contributions, Membership Dues, Exempt Function Revenues, = Line 11 Interest, Unrelated Business Income, Tax Revenues, Value of Services & Facilities, Other Sources * Exclude any unrelated business income

Gross Investment Income Ratio = 0.1% PASS Gross income from interest & dividends = Line 7 Gifts, Grants, Contributions, Membership Dues, Exempt Function Revenues, = Line 11 Interest, Unrelated Business Income, Tax Revenues, Value of Services & Facilities, Other Sources

Was your section required to file any IRS Tax Forms in 2005? ___X__ Yes, we filed form(s) __990, 990T, 1099______No

Name: James U. Piper Councilor Name:

Office: Treasurer

Signature: Signature: 238 Date: Date:

Please return TWO copies by February 15, 2006 to: American Chemical Society, Office of Executive Director, c/o Office of Local Section Activities, 1155 16th Street, NW, Washington, DC 20036

NORTHEASTERN SECTION Attachments to 2005 Financial Report

Line 23 Restricted Funds (including restricted cash) Consolidated Account 1,696,568 Esselen Trust 494,217 Richards Trust Inc Acct 39,052 Norris Trust Inc Acct 4,178 Publications Trust Inc Acct 44,116 Hill Trust Inc Acct 10,904 Levins Award Fund 8,094 Brauner Memorial Trust 24,328

Total 2,321,456

Reconciliation of lines 22 and 32 Increase in operating cash (Line 22) (1,131.49) Norris National Award paid from Norris (7,959.00) Trust Div/Int income not used for operations 45,403.79 Realized gain (loss) from sales (63,393.66) Unrealized gain (loss) (12,682.02) Tax pd in trust accts (87.71) - Line 32 (39,850.09)

Support ratios (calculations on p2 are incorrect) Gifts, grants and contributions 66,109.19 Membership fees 55,334.83 Exempt function revenues 60,438.50 Unrelated business income (net income is 0.00 zero) Dividend/interest income 111,004.08 Public support ratio 62% Investment income ratio 38%

239

ANNUAL REPORT Northeastern Section, ACS

PART IV

CHEMLUMINARY AWARDS

http://www.nesacs.org

240

PART IV - CHEMLUMINARY AWARDS

Award Category: Outstanding Performance by Local Sections

ACS Award for Outstanding Performance by Local Sections

Our Section would like to be nominated for the ACS Awards for Outstanding Performance Awards by a Local Section. These awards are given by the Local Section Activities Committee and recognize local sections that have demonstrated exceptional, overall achievement. The awards are judged in six size categories. For further information regarding the criteria used in selecting the award winners, go to: http://www.acs.org/localsections/performance.html Contact Dr. Amy Tapper Person Name:

Peptimmune, Inc. 64 Sidney St., Suite 380 Cambridge, MA 02139 Address: 617-715-8005 Phone: 617-661-8855 Fax: [email protected] Email:

Overall, NESACS has demonstrated an outstanding performance in 2005. As stated in the Section goals, the main focus of my year as Chair was to engage participation in NESACS through networking/ social events. A challenge that our section faces is that it has been difficult to get younger chemists involved in NESACS activities and to take on board positions. I believe that 2005 was the beginning of a change in our Section’s demographics. In addition to the commendable annual events of NESACS such as NCW activities, the 6th annual Connections to Chemistry, the 5th annual German Exchange Program, and the 7th annual Northeast Student Research Conference(just to name a few), new programs were held that encouraged engagement in NESACS.

There were four networking and social events in 2005, which included two brewery tours / dinners, a bike ride, and a golf tournament.

The Chair's first social/networking event at the Harpoon Brewery and No Name Restaur-ant held in January was a great success, despite the record-breaking snowfall. We had a 50% cancellation due to the inclement weather. This event was co-sponsored by the WCC and YCC. Thirty-five attended the brewery tour/lecture and the * dinner at the Boston landmark, the No Name Restaurant. Description: Please limit An even half dozen chemists from NESACS met at the Uncle Sam statue to 1,000 in Arlington on June 1 to bike and walk the Minuteman Bikeway. Words or Less After being postponed due to a late-season Nor’easter on May 27th,

241

cyclists were pleased to have a very beautiful evening for the ride. Four took a leisurely bike ride up to Lexington, where they enjoyed the evening light. Our section webmaster broke away from the pack, rocketing up the path all the way to the terminus in Bedford, about 9 miles each way. One person took a walking tour of the bike path and the town of Arlington, visiting the library and the town gardens. At dusk the group met at Krazy Karry’s Backyard BBQ for some excellent burgers and a discussion of the connections between biking and chemistry. Tom Hansen Ph.D., CMC Manager at ARIAD Pharmaceuticals told the group about the use of flow cytometry for blood analysis, and how this analytical technique was used to disqualify local cycling hero Tyler Hamilton. The ride leader was Joe Snodgrass Ph.D.,from ARIAD.

On Monday, June 6th, forty-seven golfers teed off at Wentworth Hills Country Club in Plainville in the first NESACS String Scramble Golf Tournament. Golfers came from as far away as Wisconsin to participate. Although the day started cool it turned into a beautiful sunny day for golf and the conditions on the course were perfect. Golf was preceded by a buffet luncheon. The Vertex team of Mick Hurrey, David Miller, and Ray Forslund won the spirited competition with an outstanding score of 55 (par 71). Second was claimed by the team of Marc Cadell, Jeff Wilson, Bruce Shutts, and Ed Price and third by the team of Amy Tapper, Panos Kalaritis, Brian Robbins, and Gary McGhee. The mens long drive competition was won by Mark Cirolo with a drive of 374 yards and the women’s long drive was won by Amy Tapper. The closest to the pin award was won by Brian Robbins. The awards were given at the banquet which followed the tournament. Much fun was had by all. Thanks to generous sponsorships by IRIX (Osmium level); Hovione, Lyophiliza-tion Service of New England, DSM, and Cardinal Health (Platinum level); Rhodia Pharma Solutions, Teledyne ISCO (Gold level); and Vertex, Genzyme Drug Discovery and Development, and Peptimmune (Silver level) a total of $8,400 was raised to support NESACS activities. Plans are underway for the second annual golf tournament in June 2006.

The final Chair’s networking and social event held in November, which was also co-sponsored by the YCC and WCC, was a beer tasting and dinner at the Cambridge Brewing Company. For this event I was able to get Dishman Pharmaceuticals to sponsor the cost of the beer tasting/lecture. There were thirty in attendance.

Overall these events were quite successful in getting members who usually don’t attend monthly meetings to participate and form interest in NESACS activities.

One of the other goals of the Section was to promote financial support from industry. Through the events described above as well as the Vendor Fair and the YCC Career Fair, we were success in engaging industrial support for NESACS programs. I also believe that we have developed a continuance for industrial support.

The complete redesign of the NESACS website with emphasis on the employment link and formation of a NESACS mailing list link as

242

well as the establishment of a discussion forum on the section's website (www.nesacs.org/discuss) and testing of the viability of conducting monthly meetings over the Internet allows NESACS to embrace the current level of technology which has extreme benefits for our members.

Overall, NESACS has demonstrated an outstanding performance in 2-3 2005. The main focus for NESACS in 2005 was to engage Sentence participation through newtworking/social events. There were four Abstract for new networking/social events, which included two brewery Program tours/dinners, a bike ride, and a golf tournament. Booklet Picture of : Event

Local Section Activities Committee Awards

Our Section would like to be nominated for the Most Innovative New Activity or Program in a Local Section. This award is given by the Local Section Activities Committee and recognizes a local section for an innovative new activity or program.

Contact Amy Tapper Person Name:

Peptimmune, Inc. 64 Sidney St., Suite 380 Cambridge, MA 02139 Address: 617-715-8005 Phone: 617-661-8855 Fax: [email protected] Email:

On Monday, June 6th, forty-seven golfers teed off at Wentworth Hills Country Club in Plainville in the first NESACS String Scramble Golf Tournament. Golfers came from as far away as Wisconsin to participate. Although the day started cool it turned into a beautiful sunny day for golf and the conditions on the course were perfect. Golf was preceded by a buffet luncheon. The Vertex team of Mick Hurrey, David Miller, and Ray Forslund won the spirited competition with an outstanding score * of 55 (par 71). Second was claimed by the team of Marc Cadell, Description: Jeff Please limit Wilson, Bruce Shutts, and Ed Price and third by the team of Amy to 1,000 Tapper, Panos Kalaritis, Brian Robbins, and Gary McGhee. The Words or Less mens long drive competition was won by Mark Cirolo with a drive

243

of 374 yards and the Women’s long drive was won by Amy Tapper. The closest to the pin award was won by Brian Robbins. The awards were given at the banquet which followed the tournament. Much fun was had by all. Thanks to generous sponsorships by IRIX (Osmium level); Hovione, Lyophilization Service of New England, DSM, and Cardinal Health (Platinum level); Rhodia Pharma Solutions, Teledyne ISCO (Gold level); and Vertex, Genzyme Drug Discovery and Development, and Peptimmune (Silver level) a total of $8,400 was raised to support NESACS activities.Plans are underway for the second annual golf tournament in June 2006.

2-3 The first annual NESACS Strings Golf Tournament was Sentence held on June 6th, 2005 at Wentworth Hills C.C. Forty Abstract for seven golfers partcipated and the event raised $8,400 Program for the Northeastern Section. Booklet Picture of : Event

Our Section would like to be nominated for the Best Activity or Program in a Local Section Stimulating Membership Involvement. This award is given by the Local Section Activities Committee and recognizes a local section for an activity or program that stimulated membership involvement.

Contact Amy Tapper Person Name:

Peptimmune, Inc. 64 Sidney St., Suite 380 Cambridge, MA 02139 Address: 617-715-8005 Phone: 617-661-8855 Fax: [email protected] Email:

The main focus of my year as Chair was to engage participation in NESACS through networking/social events. There were four main networking and social events in 2005, which included two brewery tours/dinners, a bike ride, and a golf tournament.

The Chair's first social/networking event at the Harpoon Brewery and No Name Restaurant held in January was a great success, despite the record-breaking snowfall. We had a 50% cancellation * due to the inclement weather. This event was co-sponsored by the Description: WCC and YCC. Thirty-five attended the brewery tour/lecture and Please limit the dinner at the Boston landmark, the No Name Restaurant. The to 1,000 Bike (or Skate, Run or Walk) the Minuteman Bikeway and the golf Words or Less tournament (which was the major 2005 networking/social event) are

244

discussed in detail in this section. The final Chair’s networking and social event held in November which was also co-sponsored by the YCC and WCC, was a beer tasting and dinner at the Cambridge Brewing Company. For this event I was able to get Dishman Pharmaceuticals to sponsor the cost of the beer tasting/lecture.

Overall these events were quite successful in getting members who usually don’t attend monthly meeting to participate and form interest in NESACS activities

2-3 The main focus of NESACS in 2005 was to engage participation in Sentence NESACS through networking/social events. There were four main Abstract for networking and social events in 2005, which included two brewery Program tours/dinners, a bike ride, and a golf tournament. Booklet Picture of : Event

245

Local Section Career Program Awards

Our Section would like to be nominated for the Outstanding Local Section Career Program Award. These awards are given by the Committee on Economic and Professional Affairs and recognize both a large to very large and a small to medium large local section that have demonstrated career programs that facilitate and contribute to a significant number of members' professional development. Only local sections with trained coordinators are eligible for the award.

Contact Ivan V. Korendovych Person Name:

Department of Chemistry Tufts University 62 Talbot Ave. Medford, MA 02155 Address: (617)627-5745 Phone: (617)627-3443 Fax: [email protected] Email:

The NESACS-YCC had continued success with their annual career services events, the career symposium and the career fair. Career Symposium 2005: Making the Transition from School to a Career: Experiences and Advice (March 10, 2005)

o The annual YCC Career Symposium was held on March 10, 2005 from 3:30-5:30pm prior to the NESACS monthly meeting at Brookline Holiday Inn. This year, the YCC concentrated on the importance of transition from school to a career, the difficulties that have to be overcome, skills that needs to be developed. Speakers at the event represented academic, industrial and governmental jobs. o This year’s speakers were Dr. Nora Conlon of the EPA, Dr. Alexander Kolchinski of Pharm-Eco, Prof. Oleg Ozerov of Brandeis University, Dr. Mark Charest of Novartis. o Each of these speakers shared their personal career experiences and answered questions from the attending students. The event was followed by a social hour where student could ask presenters more questions and network. Approximately 30 younger chemists attended the event. o NESACS monthly meeting following the event featured a career talk. This year keynote speaker was * Dr. John Fetzer of Fetzpahs Consulting, author of Career Description: Management for Chemists. The title of Please limit the presentation was Chemistry as a Soft Science to 1,000 ¢ Northeast Student Chemistry Career Fair, NSCCF Words or Less (March 31) - 2nd annual NSCCF held in Brookline Holiday

246

Inn on March 31, 2005 was a continuation of highly successful Career Fair held last year. The four-hour program constitutes a set of workshops on resume writing and interviewing, resume review as well as the career fair itself. All the parts of the program were held simultaneously. o The workshops were hosted by ACS Career Services coordinated by Dr. Daniel Eustace. Dr. Eustace engaged the workshop-attending students in discussion about searching for a job and even held a mock interview to illustrate good and bad interviewing behavior. o ACS Career Services booklets and materials were also provided to all attendees. o Representatives from 9 regional companies made themselves available for greeting and discussing employment with ~120 attending younger chemists. Companies that attended include Strem Chemicals, Inc., Merck, Novartis Institutes for Biomedical Research, Genzyme, Wyeth, Sigma-RBI, ArQule, Amgen, and the Graduate Women in Science. Many beneficial contacts were made through the Fair. One representative from Wyeth said, "Very successful event, we have collected fewer resumes from bigger career fairs. Looking forward to another job fair next year!" ¢ Results of a survey handed in to the participants of the Career Fair were very positive.

2-3 The NESACS-YCC had continued success with their Sentence annual career services events, the career symposium and Abstract for the career Program fair. Booklet Picture of : Event

Younger Chemists Committee (YCC) Awards for Local Sections and Divisions

Our Section would like to be nominated for the Outstanding Local Section Younger Chemists Committee Award. This award is given by the Younger Chemists Committee and recognizes local section YCCs that demonstrate organizational stability, solid membership and participation, involvement with their ACS local section, and an overall balance of activities (career development, scientific, social, outreach, etc.) (Note: to be eligible for this award you must also complete the YCC annual report form and include it in Appendix 6 of the local section annual report.)

Contact Ivan V. Korendovych Person Name: Address:

247

Department of Chemistry Tufts University 62 Talbot Ave. Medford, MA 02155

(617)627-5745 Phone: (617)627-3443 Fax: [email protected] Email:

Followed by expansion in 2004 the Northeastern Section Younger Chemists Committee (NSYCC) in 2005 focused on improving organization of several new events introduced in previous years to lay solid foundation for future expansion. We have much improved organization of all our events. Our new event Northeast Student Chemistry Career Fair (NSCCF), introduced in 2004, this year turned out to be even a greater success. With help of ACS career services we were able to increase attendance up to the point where we could barely cope with demand for resume reviews! Several of the attendees came away from the event with job interviews and offers! Costs were offset by charging participating companies $500 for their booths. In 2006 we plan to get more ACS career representative for our event.This year’s 7th Northeastern Student Chemistry Research Conference (NSCRC) moved to a different location for the first time in seven years. The Ray and Maria Stata Center at MIT provided exceptional facilities for the conference and help attract younger chemists to present their research! NSCRC 2005 was a great success in terms of attracting new students and improving organization.

The annual YCC Career Symposium was held on March 10, 2005. This year, the YCC concentrated on the importance of transition from school to a career, the difficulties that have to be overcome, skills that needs to be developed. Speakers at the event represented academic, industrial and governmental jobs.

This year's week-long exchange between the Gesellschaft Deutscher Chemiker-Jungchemikerforum (German Chemical Society - Younger Chemists Committee) and the Northeastern Section Younger Chemists Committee, held during the week of April 3, was a great success. Ten graduate and two undergraduate students from colleges and universities in the Boston area have traveled to Germany to participate in the 5th NESACS/GDCh exchange program. Sarah Chobot, a graduating senior at Boston University was awarded * the prize for the best oral presentation at the 2005 Description: Frühjahrssymposium that was held in Berlin, Germany, April 7-9. Please limit Sarah's prize consists of a cash award of 250 euros and a to 1,000 flight ticket to attend any scientific meeting in the world Words or Less during the next year.

248

We have also significantly improved the number and quality of our social events. The approach we took this year was not only to organize our own events but actively collaborate with other committees of the local section as well as organizations not associated with NESACS directly (such as Graduate Women in Science). This allowed us to reach more people interested in our activities.

We have decreased our spending: we were able to save $2000 with the same or improved quality of our events. They have also increased committee membership. As of the writing of this report, the YCC has 189 members on its mailing list - a significant improvement over 2004. Our successful website has also seen approximately 3000 hits in the past year.

The Northeastern Section YCC (NSYCC) built upon its improved organization from 2004. The NSYCC website (www.nsycc.org) continued to attract more event attendees and members. The NSYCC once again held annual events such as a career symposium featuring the importance of on the importance of transition from school to a career, a student research conference featuring cash prizes for research presentations, and the German Exchange Program sending 10 graduate and 2 undergraduate students to Germany for a week of science and networking, 2nd Northeast Student Chemnistry career fair (NSCCF), continuing and improving highly successful event established last year. NSCCF featured resume writing and interviewing workshops by ACS Career Services and a job fair attended by job-seekers and representatives from 2-3 eight companies from the Northeastern region. The NSYCC Sentence also hosted a variety of social events for students in the Abstract for Boston area. We have established fruitful collaborations with Program other chapters of NESACS and other organizations. Booklet Picture of : Picture - YCC ChemLum nomination.doc Event

249

Society Committee on Education Awards

Our Section would like to be nominated for the ACS Student Affiliates Chapter Interaction Award. This award is given by the Society Committee on Education and recognizes an ACS local section that has contributed significantly to the pre-professional development of ACS Student Affiliates (SA) in its region. The award recipient will have demonstrated considerable interaction with SA chapters by initiatives such as inviting chapter members to participate in local section monthly meetings and activities; assisting with SA chapter activities by providing speakers or volunteers or contributing to the overall success of the chapters in other ways; and encouraging SA attendance at ACS national and regional meetings by providing travel assistance to chapters in their section.

Contact Amy Kallmerten Person Name:

12 Fairfax Street Somerville, MA 02144 Address: 603-491-5889 Phone:

Fax: [email protected] Email:

The Northeastern University Student Affiliates of the American Chemical Society has undergone a transforma- tion in the past few years. The group has quadrupled in size - gone from being a small social club into an organization that acts as central glue in the community, linking its members to the department, to NESACS and to industry. We have hosted the NESACS education night two years in a row as well as run registration at other meetings and contributed a visible presence in monthly meetings. The chapter now has a direct interaction with the chemistry major retaining almost all of the students in the majors as members and helping to shape the evolving curriculum to best prepare students for life beyond college. An important fact not to be overlooked is the number of women succeeding at Northeastern. 58% of the incoming freshman class this year are women and by no favor these women have been admitted and continue to do great things based on their own intelligence work ethic. In a historically male dominated field, it is important to know that women are being given great chances for success. Beyond the chemistry department and major the group has done things to reach out to the university * community, providing demonstrations and activities each Description: National Chemistry week. We feel that providing good, Please limit useful career counseling is one of the best things our to 1,000 group can offer its members. Beyond the professional Words or Less aspect of the group-- NUSAACS puts on a host of social

250

events including visiting Six Flags and Hyland orchards, having movie nights, dinners and many other events. They also participate in the betterment of the general community by volunteering at Rosie’s Place (a shelter for women) and running events such as food drives to benefit the Boston food bank. Five members will be attending the national meeting sponsored by the chemistry department this March. They will be presenting posters in a range of areas from organic chemistry research to outreach through NUSAACS and to our evolving curriculum.

Networking and making an individual mark on the world seems to keep finding a central place in NUSAACS focus. Our focus has shifted from creating links, to preserving and maintaining the bonds while developing an outreach to local high schools. Our members will be visiting local high schools as well as their students visiting NU. Our hope is to continue the networking web. We hope to use our resources to help the high school students to participate in exciting, interesting and relevant lab experiments, succeed in their advanced placement classes and start up student affiliate chapters in their schools. Assisting in the success and providing links and open doors for our members has become one of the main missions of the group.

The Northeastern University Student Affiliates of the American Chemical Society has undergone a transformation 2-3 in the past few years. The group has quadrupled in size- Sentence - gone from being a small social club into an organiza- Abstract for tion that acts as central glue in the community, linking Program its members to the department, to NESACS and toindustry. Booklet Picture of : Event

251

ChemLuminary Awards for National Chemistry Week

Our Section would like to be nominated for the Most Orginal Hands-on Activityor Chemical Demonstration Recognizes a local section for conducting a novel or unusual hands-on activity or chemical demonstration that adheres to the NCW Safety Guidelines. (This award if for a single activity or demonstration, not an event.) Judging Criteria: Creativity and Innovation, Volunteer Involvement/Collaboration, Audience Reached, and Publicity Contact Christine Jaworek-Lopes Person Name:

Emmanuel College 400 The Fenway Boston, MA 02115 Address: (617)264-7614 Phone: (781) 659-2231 Fax: [email protected] Email:

* Name of the Activity/Program: Boston Enjoys Sunny Description: Weather after Days of Rain and Makes Nature Prints Please limit to 1,000 Date Conducted: Sunday, October 16, 2005 Words or Less

252

Location of the Event: Wellesley College

Number of Participants: Number of volunteers: ~10 Student Affiliates Approximate size of audience reached: 350

For many children, creating artwork may be considered playing with toys. In this activity, light sensitive paper was purchased www.teachersource.com. A variety of objects (buttons, foam shapes, lace, shells, and leaves) were left on the table for individuals to decorate the paper by covering it with the aforementioned objects. The object- covered paper was then brought outdoors for a short period of time 2-3 minutes. The exposed portion underwent a chemical reaction converting the coating to a water- insoluble pigment. Upon returning indoors, the paper was dipped in water allowing for the water soluble pigment (remaining on the unexposed portion to be washed away). The artwork was allowed to dry on a clothesline while the participants attended a number of other hands-on activities.

This event was enjoyed by children and adults equally. It was a very clean activity and since it had rained in Boston for several days prior to the event; participants enjoyed going outside for a portion of the activity.

To many children, making artwork equals playing. In this hands-on activity, children of all ages made Nature 2-3 Prints, a simple, yet fun activity. During this activity, Sentence participants learned about light sensitive reactions while Abstract for being able to enjoy the outdoors after several rainy Program Boston days. Booklet Picture of : Event

Our section would like to be nominmated for the Outstanding On-going NCW Event Recognizes a local section for an outstanding event that has been conducted for at least three years (not awarded to the same section more than once in a 5 year period). Judging Criteria: Program Quality, Program Longevity, Volunteer Involvement/Collaboration, Audience Participation, Publicity, and Program Growth Contact Christine Jaworek-Lopes Person Name:

Address: Emmanuel College

253

400 The Fenway Boston, MA 02115

(617)264-7614 Phone: (781) 659-2231 Fax: [email protected] Email:

Name of the Activity/Program: Phyllis A. Brauner Memorial Lecture

Date Conducted: Sunday, October 16, 2005

Location of the Event: Wellesley College

Number of Participants: Number of ACS members involved: 50 Approximate size of audience reached: 350

The Phyllis A. Brauner Memorial Lecture honors the memory of Phyllis A. Brauner (1916-2000) and her steadfast dedication to the chemistry community and to teaching chemistry to the public.

Phyllis was an instructor of chemistry at Northeastern University as well as Swarthmore College; she was a professor of chemistry at Simmons College for 34 years. Actively involved in the Northeastern Section of the American Chemical Society, Phyllis was chair of the section in 1974, a Member of the Board of Directors, a Councilor of the section, a Trustee, and the Editor of the Nucleus.

Over the years, Phyllis organized numerous lectures featuring chemistry educators, such as Hubert Alyea, Jerry Bell, and Dudley Herschbach. The lectures have always been free to the public and have drawn enthusiastic audiences of all ages.

In 1986, Phyllis played an integral role in starting a Holiday Lecture Series at the Museum of Science. Professor Bassam Shakhashiri presented the inaugural lecture on December 29, 1986.

In commemoration of Phyllis’ lifetime of work the Northeastern Section of the ACS has instituted the annual Phyllis A. Brauner Memorial Lecture to be held during National Chemistry Week. On November 4, 2001, the first memorial lecture was held at the Museum of Science in * Boston. Professor Bassam Shakhashiri presented a lecture Description: entitled Picasso, Da Vinci, Shakhashiri: Artistry and Please limit Chemistry. Approximately 400 individuals attended this to 1,000 free lecture. On October 20, 2002, Professor Bassam Words or Less Shakhashiri regaled audiences at the Museum of Science-

254

Boston with a Phyllis A. Brauner Memorial Lecture entitled Quest for Chemistry: Moles, Molecules, and Mummies. Once again, approximately 400 individuals attended this free lecture. The third memorial lecture was held on October 19, 2003 at Wellesley College; approximately 350 individuals attended the lecture- demonstrations performed by Professor Bassam Shakhashiri. Highlights of the lecture included: the methanol cannon and demonstrations of complete vs. incomplete combustion reactions. The fourth memorial lecture was held on October 17, 2004 at Wellesley College; approximately 275 individuals attended the lecture-demonstrations performed by Dr. Jerry Bell of the American Chemical Society, Dr. William Dills of UMASS Dartmouth, and Dr. James Golen of UMASS Dartmouth. The fifth memorial lecture was held on October 16, 2005 at Wellesley College; approximately 350 individuals attended Dr. Shakhashiri’s captivating lecture- demonstrations. This lecture was the centerpiece of a day of hands-on activities featuring volunteers of all ages from retired chemists to student affiliates and involving participants from preschoolers through high school.

This year’s event at Wellesley College featured the five student affiliate chapters participating in a single NESACS NCW event, with approximately 50 SAACS students sharing the joy of toys by having visitors make Nature Prints, Bunny Copters, making superballs, and making slime. Volunteers were treated to an informal lunch with Dr. Shakhashiri a brief break from the day’s whirlwind of activities.

For the last five years, the Northeastern Section of the American Chemical Society and either the Museum of Science or Wellesley College has co-sponsored these lectures. These popular lecture demonstrations have been performed to capacity filled lecture halls for the last three years. This event has become a highlight of the Northeastern Section’s National Chemistry Week Kick-off Event.

The Phyllis A. Brauner Memorial Lectures honors the memory of Phyllis A. Brauner (1916-2000), a dedicated educator in and out of the classroom. For the last five years, the Brauner Memorial Lecture has been a part of the National Chemistry Week Kick-Off Event for the 2-3 Northeastern Section of the American Chemical Society. Dr. Sentence Jerry Bell, Dr. William Dills, and Dr. James Golen or Abstract for Professor Bassam Shakhashiri has presented to capacity- Program filled lecture halls at each of these memorial lectures. Booklet Picture : of Event:

255