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E N O A E S S S L T A E A C R C I N S M S E E H C C TI N O CA April 2018 Vol. XCVI, No.8 N • AMERI

Monthly Meeting

Esselen Award Meeting at Harvard Jennifer A. Doudna to Receive 2018 Award 2018 NESACS Candidates for Election

In Memory of Ted Taylor

By Michael P. Filosa NESACS at Fenway Park

May 14, 2018, 7:10 pm Tickets Available Gustavus John Esselen II

A brief history of the Award: disaster of Bhopal on every chemist’s and has become a much coveted prize. In 1985 an inquiry was made as to mind and the public receiving nothing -By Myron S. Simon, assisted by Phyllis whether the Section would wish to but negative stories about chemistry A. Brauner, Arno Heyn and Arthur S. honor another former leader of the from the media, this was to be a small Obermayer with suggestions from Ed- Northeastern Section. The Esselen fam- step toward establishing a balance. ward R. Atkinson. “The Last Quarter ily proposed to donate a sum of money Mr. Esselen proposed to add a Century, Part I,” The Nucleus, North- to provide for an award in the memory bronze medal to the monetary award. A eastern Section of the American Chem- of Gustavus John Esselen II, Chairman prominent sculptor from Newton, Mas- ical Society, Inc., February, 1998, pp in 1922 and 1923, and a member of the sachusetts, Lloyd Lillie, was selected to 17-18. ACS Board of Directors for many years. prepare the design which was then ap- In 1948, Dr. Esselen received a special proved by members of the Esselen fam- A brief biography: Gustavus John Esselen, II was born in award, the James Flack Norris Honor ily. The fact that Dr. Esselen had done Roxbury, Massachusetts, June 30, 1888, Scroll, “as the person who has done much work in plastics during his career the son of Gustavus J. and Joanna most to advance the interests of the led his son to propose that the bronze Blyleven Esselen. All of his higher edu- Northeastern Section.” A committee medal be imbedded in a block of clear cation was obtained at Harvard Univer- consisting of William O. Foye, Truman plastic, which was done, to give a very sity where he was awarded the A.B. S. Light, Arthur S. Obermayer, and distinctive addition to the ceremonial (magna cum laude) in chemistry in 1909 Myron S. Simon, Section Chairman, presentation. and a doctorate in 1912. In that same met with Esselen’s son, Gustavus J. Es- The first presentation of the Gus- year he married Henrietta W. Locke who selen III, and recommended to the tavus John Esselen Award for Chemistry with three children survived him at the Board of Directors that the Section ac- in the Public Interest was made in 1987 time of his death on Oct. 22, 1952. cept the offer, which it did. The commit- to F. Sherwood Rowland and Mario J. Until 1921 he was a member of the tee and Mr. Esselen agreed that the Molina for their work on the chemical research staff of General Electric Co. in award should not be in a specific field processes which were destroying the Lynn and then of Arthur D. Little, Inc. of chemistry, but instead should have the stratospheric ozone layer, explaining the of Cambridge, MA. At the latter firm he special purpose of emphasizing the pos- formation of the Antarctic Ozone Hole. was associated with Little and Wallace itive values of chemistry to mankind. In Since then, the award has been given to Murray in the fabrication of a “silk” light of the climate of the day, with the chemists in several fields of chemistry purse from reconstituted collagen, in turn derived from a sow’s ear. In 1930 he founded Gustavus J. Esselen, Inc., which subsequently became Esselen Re- search Corporation and then, following a merger, Esselen Research Division of United States Testing Co., Inc. During this period he was involved in solving a variety of problems submitted by indus- trial clients. Among these was the devel- opment of anhydride curing agents for epoxy resins and poly(vinylbutyral) as an improved material for safety glass, both of which enjoyed considerable commercial success. More than 40 U.S. patents were issued as a result of his re- search efforts. Esselen was a member of the American Chemical Society for 43 years during which time his outstanding services to the society and the profes- sion of chemistry were recognized and honored, not only in his native New England, but throughout the United States. He was twice chairman of the Northeastern Section, ACS (1922-23) continued on page 9

2 The Nucleus April 2018 The Northeastern Section of the American- Chemical Society, Inc. Contents Office: Anna Singer, 12 Corcoran Road, Burlington, MA 01803 (Voice or FAX) (781)272-1966. Gustavus John Esselen II 2 e-mail: [email protected] ______NESACS Homepage: The Award and the Man http://www.NESACS.org Officers 2018 2018 NESACS Candidates for Election 4 Chair ______Mindy Levine 35 Cottage St Monthly Meeting 5 Sharon, MA 02067-2130 ______(516)697-9688 Esselen Award Meeting at the Charles Hotel and Pfizer Lecture [email protected] Hall. Jennifer A. Doudna, UCal Berkeley to Receive 2018 Esselen Chair-Elect Andrew Scholte Award. Date: Friday, April 27, 2018. Sanofi Waltham, MA In Memory of Ted Taylor 6 617-459-5145 [email protected] By Michael P. Filosa Immediate Past Chair Leland L. Johnson, Jr. Historical Notes 6 Euretos ______Cambridge, MA William Klemperer, Edward C. Taylor, Jr. and John J. Giuffrida +1.617.304.6474 [email protected] Announcements 2,7,9 Secretary ______Michael Singer MilliporeSigma Northeast Student Chemistry Research Conference, NESACS 3 Strathmore Rd, Natick, MA 01760 at Fenway Park, Senior Chemists Luncheon (774)290-1391, [email protected] Treasurer Gustavus John Esselen Award 8 Ashis Saha ______67 Bow St Prior Recipients Arlington, MA 02474-2744 (978)212-5462 Business Directory 11 [email protected] ______Auditor Patrick Gordon Calendar 12 Archivist ______Ken Mattes Trustees Cover: Peter C. Meltzer, Dorothy Phillips, Ruth Tanner Professor Jennifer A. Doudna, University of California at Berkeley, Directors-at-Large 2018 recipient of the Gustavus J. Esselen Award for Chemistry in the Public In- David Harris, June Lum, Michael P. Filosa, terest. (Photo courtesy of Professor Doudna). John Neumeyer, James U. Piper, Ralph Scannell Councilors/Alternate Councilors Editorial Deadlines: Term Ends 12/31/2018 Summer-September Issue: July 22, 2018 Katherine Lee Chris Moreton October 2018 Issue: August 22, 2018 Catherine E. Costello Ajay Purohit Ruth Tanner June Lum Kenneth Mattes Malika Jeffries-EL Jackie O’Neil Joshua Sacher Term Ends 12/31/2019 Thomas R. Gilbert Ashis Saha Mary Jane Shultz Mary A. Mahaney Michael Singer Jerry P. Jasinski The Nucleus is published monthly, except June and August, by the Northeastern Section of the American Lisa Marcaurelle Raj (SB) Rajur Chemical Society, Inc. Forms close for advertising on the 1st of the month of the preceding issue. Text Leland L. Johnson, Jr. Matthew M. Jacobsen must be received by the editor six weeks before the date of issue. Term Ends 12/31/2020 Editor: Michael P. Filosa, Ph.D., 18 Tamarack Road, Medfield, MA 02052 Email: Michael P. Filosa Robert Lichter [email protected]; Tel: 508-843-9070 Carol Mulrooney Morton Z. Hoffman Patricia A. Mabrouk Sonja Strah-Pleynet Associate Editors: Myron S. Simon, 60 Seminary Ave. apt 272, Auburndale, MA 02466 Anna W. Sromek Andrew Scholte Morton Z. Hoffman, 23 Williams Rd., Norton, MA 02766 Sofia A. Santos Patrick M. Gordon Board of Publications: James Phillips (Chair), Mary Mahaney, Ajay Purohit, Ken Drew, Katherine Lee All Chairs of standing Business Manager: Vacant: contact Michael Filosa at [email protected] Committees, the editor of THE NUCLEUS, and Advertising Manager: Vacant: contact Michael Filosa at [email protected] the Trustees of Section Calendar Coordinator: Xavier Herault, Email: [email protected] Funds are members of the Photographers: Morton Hoffman and James Phillips Board of Directors. Any Coun cilor of the American Chemical Society Proofreaders: Donald O. Rickter, Morton Z. Hoffman residing within the section area is an ex officio Webmaster: Roy Hagen, Email: [email protected] member of the Board of Directors. Copyright 2018, Northeastern Section of the American Chemical Society, Inc.

The Nucleus April 2018 3 2018 New NESACS Sponsors 2017 Platinum $5000+ NESACS NESACS Boston Foundation Esselen Award SK Life Science Candidates Bylaws Allow Amgen, Inc Johnson Matthey Vertex Pharmaceuticals for Election Electronic Davos Pharma Chair-Elect Biogen Dr. Sofia Santos Elections PCI Synthesis Dr. Anna Sromek Navin Fluorine International Ltd Councilor/Alternate Councilor 2018 will be the first electronic Gold $3000 up to $5000 Dr. Ajay Purohit NESACS Election – Watch Merck Research Corp Dr. Ashis Saha your email! Signal Pharmaceuticals Ms. June Lum J-Star Research Dr. Malika Jeffries-El Like the National American Chemical IPG Women Chemists Dr. Katherine Lee Society Elections and the Division of Dr. Catherine Costello Organic Elections, NESACS will now Abbvie Dr. Ruth Tanner hold electronic elections. This change Silver $1500 up to $3000 Dr. Kenneth Mattes needed to be described in the NESACS Mettler Toledo Bylaws before it could be implemented. Dr. Morton Z. Hoffman Sanofi US Services The approval of new bylaws at the Jan- Dr. Andrew Scholte Warp Drive Bio Dr. Patrick Cappillino uary Meeting now allows NESACS to Pfizer Dr. Raj Rajur move to a more member-friendly and ef- Dr. Joshua Sacher ficient way of holding elections. It is LAVIANA Dr. Mariam Ismail also more cost-effective. Strem Chemicals Dr. Hicham Fenniri Historically, NESACS has pub- Bronze $500 up to $1500 Dr. Daljit Matharu lished candidate statements in the May Chemical Computing Group Treasurer (2 year term) Nucleus which was assembled in a large Xtuit Pharmaceuticals envelope with a paper ballot and a return Dr. Ashis Saha Cydan Development Inc envelope. This assemblage was then Trustee (3 year term, 1 elected) mailed to each of our 6000 members! Achillion Pharmaceuticals Dr. Peter Meltzer Alkermes continued on page 10 Dr. Bob Lichter FLAMMA ResMed: Residential School on Medicinal Director-at-Large (3 year term, 2 R Safety Partners Inc elected) Chemistry and Biology in Drug Discovery Piramal Pharma Solutions’ Dr. June Lum June 10-15, 2018 Drew University, Madison, NJ Selvita, Inc. Dr John Neumeyer Organix Dr. John Burke This graduate level course concentrates on the fundamentals that are useful in drug discovery spanning initial target assay CreaGen Life Science Nominating Committee (1 year evaluation through clinical development. Case histories of Entasis Therapeutics term, 2 elected) recent successful drug development programs will also be Morphic Therapeutic Dr. Michael P. Filosa presented. The five-day program covers: Dr. Sonya Strah-Pleynet Principles of Med Chem DMPK Interchim, Inc Cheminformatics Toxicophores Xtal Biostructures Norris Committee (4 year term, 2 Lead ID & Optimization GPCRs Quartet Medicine elected) Epigenetics Kinase Inhibitors Fragment-based Drug Design Ion Channels Anton Parr USA Dr. K. M. Abraham Structure-based Drug Design Enzyme Inhibitors Dr. Vasiliki Lykourinou Drug-like Properties Bioisosteres Biotage Protein-Protein Interactions Preclinical Toxicology Bioduro Dr. Mark Tebbe Molecular Modeling Clinical Development Petition Candidates: “Any group com- Antibody-Drug Conjugates Novalix Pharma prising two per cent or more of the Bill Greenlee, Vince Gullo & Ron Doll – Co-organizers Thermo Fisher Northeastern Section may nominate Cresset Group candidates……” See NESACS website Attendees will be staying at the Madison Hotel Custom NMR Services u for details. www.drew.edu/resmed e-mail: [email protected] phone: 973/408-3787; fax: 973/408-3504

4 The Nucleus April 2018 Biography Monthly Meeting Jennifer A. Doudna, Ph.D The 978th Meeting of the Northeastern Section of the American As an internationally renowned profes- sor of Chemistry and Molecular and Cell Chemical Society-Esselen Award Meeting Biology at U.C. Berkeley, Doudna and Friday, April 27, 2018 her colleagues rocked the research world in 2012 by describing a simple way of The Charles Hotel, Cambridge, MA editing the DNA of any organism using Regattabar, One Bennett St., 3rd Floor an RNA-guided protein found in bacte- 5:00 pm Social Hour ria. This technology, called CRISPR- 6:00 pm Dinner Cas9, has opened the floodgates of possibility for human and non-human Harvard University, Cambridge, MA applications of gene editing, including Mallinckrodt Building, 12 Oxford St assisting researchers in the fight against 8:00 pm Award Meeting HIV, sickle cell disease and muscular Pfizer Lecture Hall (MB23), ground floor. dystrophy. Doudna is an Investigator Andrew Scholte, NESACS Chair-Elect, presiding with the Howard Hughes Medical Insti- Welcome and Award History – Karen Allen, tute and a member of the National Acad- Chair, Esselen Award Committee emy of Sciences, the National Academy of Medicine, the National Academy of Presentation of the Award - Gustavus J. Esselen, IV Inventors and the American Academy of Introduction of the Award Recipient – Michael A. Marletta, Arts and Sciences. She is also a Foreign 2007 Esselen Award Winner, University of California Berkeley Member of the Royal Society, and has received many other honors including Re-writing the Code of Life: The Impacts and Ethics of Genome the Breakthrough Prize in Life Sciences, Editing – Jennifer A. Doudna, Howard Hughes Medical Institute the Heineken Prize, the BBVA Founda- Investigator; Li Ka-shing Chancellor’s Chair in Biomedical and tion Frontiers of Knowledge Award and Health Sciences, Professor, Departments of Molecular & Cell Biol- the Japan Prize. She is the co-author ogy and Chemistry at University of California Berkeley; Executive with Sam Sternberg of “A Crack in Cre- Director, Innovative Genomics Institute ation,” a personal account of her research Dinner reservations should be made no later than noon, Friday, April 20. Reser- and the societal and ethical implications u vations are to be made using EventBrite services: https://2018-esselen-nesacs. of gene editing. eventbrite.com. Select the Gustavus John Esselen Award for Chemistry in the Public Interest and the appropriate ticket package. Members, $30.00; Non-mem- bers, $35; Retirees, $20; Students, $10. Reservations for new members and for Abstract additional information, contact the secretary Anna Singer at (781)272-1966 or e-mail at [email protected]. Reservations not cancelled at least 24 hours in CRISPR Systems: Chemistry and advance must be paid. Applications of Gene Editing THE PUBLIC IS INVITED – RESERVATIONS ARE REQUIRED Gene editing with CRISPR technology is transforming agriculture and biomed- Limited Free Parking available in the Garage at 52 Oxford St. Identify yourself icine. Understanding the underlying as attending the Esselen/Harvard Chemistry event and the guard will direct you. chemical mechanisms of RNA-guided Parking is also available at the Charles Hotel: For arrival after 5:00PM, self- u DNA and RNA targeting provides a parking is $10; valet is $15. foundation for both conceptual advances and technology development. I will dis- cuss how bacterial CRISPR adaptive immune systems inspire creation of New Members powerful genome engineering tools, en- abling advances in understanding the Invitation to attend a meeting fundamental chemistry and biology of You are cordially invited to attend one of our upcoming Section meetings as a guest living systems and paving the way for of the Section at the social hour and dinner preceding the meeting. applications in agriculture and biomed- Please call Anna Singer at 781-272-1966 between 9am-6pm, or email: secre- icine. I will also discuss the ethical chal- u tary(at)nesacs.org by noon of the first Thursday of the month, letting her know that lenges of some of these applications. u you are a new member.

The Nucleus April 2018 5 In Memory Historical of Ted Taylor Notes By Michael P. Filosa William Klemperer The passing of Ted Taylor is not just the October 6, 1927–November 5, 2017 passing of an icon of Organic Chem- William Klemperer, Erving Professor of istry, but the loss of a long-time friend Chemistry Emeritus at Harvard Univer- and mentor. sity, died November 5 at the age of 90. In addition to Ted’s well-known Bill was a physical chemists with a pri- consulting activities with Eli Lilly that mary expertise in molecular spec- led to the development of the anti-can- Two contemporaries at the 2010 Boston ACS troscopy. cer drug, Alimta, Ted was a long-time Meeting: (L) Myke Simon, Harvard A.B. 1946, He was born in New York City. consultant to the Polaroid Corporation. Ph.D. 1949 and (R) Ted Taylor, Cornell A.B. 1946 and Ph.D. 1949. (Photo by Michael Filosa). Upon graduation from New Rochelle He followed Saul Cohen and Nobel High School in 1944 he joined the U.S. Laureates, Robert B. Woodward and Sir acid-amplifiers or the thermal imaging Navy Air Corps. In 1946 he entered Derek H. R. Barton in that role. efforts that led to the invention of ZINK Harvard and majored in Chemistry. At Ted had a natural connection to Po- paper and the Opal photo kiosk technol- Harvard he met and married his wife, laroid. His expertise and that of his stu- ogy. Elizabeth Cole, a Radcliffe student. dents in heterocyclic chemistry was very We would talk about the dye chem- Upon receiving his A. B. in 1950, valuable to Polaroid’s organic chemistry istry and developer chemistry we were Bill and Elizabeth headed to the Univer- efforts. working on to support our legacy silver sity of California, Berkeley where he re- One of his Ph.D. students, Alan halide imaging products. ceived his Ph.D. in Physical Chemistry Borror was the head of Organic Chem- This work included the dimethyl- under the direction of George Pimentel. istry at the time of my arrival at Polaroid terephthalamide-hydroquinone com- After a semester as an instructor at in late 1979. In 1988 John Warner joined plexes developed by John Warner, Berkeley he returned to Harvard as an Polaroid after receiving his Ph.D. with which solved stability, and solubility is- instructor in July 1954. He moved rap- Ted. sues with several of our preferred hydro- idly up the academic ladder and became Director of Chemical Research, quinone developers. a full professor in 1965. Over his career Lloyd D. Taylor, had a great affinity for As Polaroid’s chemical research ef- he mentored 67 Ph.D. students, 34 post- Ted, his work, and his students. Lloyd fort diminished through the 1990’s it be- doctoral fellows and many undergradu- encouraged John to study hydrogen- came harder to find a full day of topics continued on page 7 bonded complexes and use them to four times a year. Given Ted’s wide- solve some of Polaroid’s chemical prob- ranging interests and enthusiasm, it was fish stocked in the failed pond. lems. These complexes were the genesis never a problem. Ted was also a passionate golfer. of John’s interest in the principles of Ted, as much as he could, would He told us the story of how he was a Green Chemistry. tell us about his work leading to Alimta, passionate tennis player until he reached Around 1991 Ted stopped his con- the toxicity issue encountered in its test- 60. At that point he decided he needed a sulting relationship with Kodak and be- ing and its solution (addition of folic new sport and that it would be one he came the Organic Chemistry consultant acid to the treatment), or his experiences could share with his wife. Ted decided for Polaroid Chemical Research. After a as an expert witness at various trials. that sport was golf and he became a low- year or two I became the host for his These included trials in which his own handicap golfer. quarterly visits. inventions were attacked. A number of us would meet Ted on Ted loved to stop in Cambridge on One interesting story I recall is the his visits to play golf. I remember one his way to Vermont and would stay at the industrial espionage that happened dur- time meeting him at Stow Acres and Marriott in Kendall Square. We would ing his Alimta efforts. New targets were playing the old South Course. We had meet for dinner at the Legal Sea Foods drawn up and were in a briefcase be- extra time so we went to the driving downstairs. This was one of his favorite longing to one of his students. The brief- range and spend the end of our session places. I think I developed my taste for case was stolen and the structures inside using wedges to aim at the flagsticks. Cajun-style blue fish at those dinners. it started appearing in the patents of a During our round I had one of the The next morning we often enjoyed foreign competitor. more successful experiences in my the breakfast buffet at the Marriott. We Another story was the fishpond he mediocre (and limited) golf career. On th then spent the day discussing Polaroid attempted to have constructed on his the 18 hole I hit a nice (straight) drive chemistry. 500-acre property in Woodstock, Ver- from the elevated tee that carried the Steve Telfer would talk about his mont. It turned out to be an expensive, pond in the middle of the fairway. latest efforts to reinvent imaging with but entertaining fiasco except for the continued on page 10

6 The Nucleus April 2018 NESACS at Fenway Park! Monday, May 14th, 2018 - 7:10 pm Oakland Athletics vs. Red Sox Thank you to Doris Lewis for securing our seats in the Grand Stand again this year.

Join us for an evening at Fenway Park for NESACS SummerThing! Tickets are $35 each To purchase tickets, please use our Eventbrite site: https://www.eventbrite.com/e/nesacs-summerthing-monday-may-14th-tickets- 43023952801

Historical Notes American Academy of Arts and Sci- sity of Illinois in 1951 before moving to ences (1963) and the National Academy Princeton in 1954. He was appointed the Continued from page 6 of Sciences (1969). A. Barton Hepburn Professor of Organic ates. He became an emeritus professor Bill is survived by his wife and his Chemistry in 1966, a position he held in 2002. children, Joyce, Paul and Wendy. until 1997, when he was appointed From 1979-1981 he served as an Emeritus Professor and senior research Assistant Director for the Mathematical Edward C. Taylor, Jr. chemist. and Physical Sciences. He also served as August 3, 1923–November 22, 2017 Taylor wrote more than 460 papers an advisor to NASA and as a consultant Ted Taylor, A. Barton Hepburn Profes- and holds 52 U.S. Patents. He is the au- to assess experiments related to stratos- sor of Organic Chemistry, Emeritus, thor or co-editor of 89 books on hetero- pheric ozone depletion. He received passed away November 22, 2017 at the cylic chemistry and organic synthesis. major awards from the American Chem- age of 94 while living at the home of his Ted is survived by his son, Ned ical Society, the American Physical So- daughter, Susan Spielman in St. Paul, Taylor (Connie) and his daughter Susan ciety and the Royal Chemistry Society. Minnesota. He was preceded in death in Spielman (Rick). He is also survived by From the American Chemical Soci- 2014 by his wife of 68 years, Virginia 9 grandchildren and 20 great-grandchil- ety he received the Irving Langmuir (Crouse) Taylor. dren. Award (1980), the Peter Debye Award Ted was born in Springfield, Mas- in Physical Chemistry (1994) and the E. sacusetts on August 3, 1923. He quickly John J. Giuffrida Bright Wilson Award in Spectroscopy exhausted the chemical offerings of 1931–2014 (2001). He received the Earle K. Plyler Hamilton College and moved to Cornell John J. Giuffrida,82, of Laconia, NH Prize for Molecular Spectroscopy from University to complete his A. B. and passed away on Sunday afternoon, June the American Physical Society (1983) Ph.D. degrees. After receiving his Ph.D. 8, 2014 as the result of a tragic accident. and the Faraday Medal and Lectureship in 1949 he was a Merck Postdoctoral His family was with him when he from the Royal Society of Chemistry Fellow with Leopold Ruzicka in Zurich, passed. (1995). Switzerland. John was born in Lawrence, Mas- Bill was elected a member of the He joined the faculty of the Univer- continued on page 10

The Nucleus April 2018 7 Gustavus John Esselen Award Prior Recipients of the Gustavus John Esselen Award 1987 - F. Sherwood Rowland, Univer- 2000 - William A. Pryor, Louisiana State 2011 - Arthur J. Nozick, Senior Re- sity of California at Irvine, and Mario University. Vitamin E and the Preven- search Fellow, National Renewable J. Molina, now at the Massachusetts tion of Heart Disease. Energy Laboratory and Professor Ad- Institute of Technology. Discovery of 2001 - Joseph M. DeSimone, University junct, Department of Chemistry and the Influence of Chlorofluorocarbons of North Carolina and North Carolina Biochemistry, University of Colorado, on the Ozone Layer. State University. Green Chemistry for Boulder. Prospects and Novel Ap- 1988 - Alfred P. Wolf and Joanna S. Sustainable Economic Development. proaches for the Low Cost Power Con- Fowler, Brookhaven National Labora- 2002 - Ronald Breslow, Columbia Uni- version of Solar Photons to Electricity tories, Chemical Procedures to Make versity. Chemistry Lessons from Biol- and Solar Fuels Positron Emission Tomography a Prac- ogy and vice versa. 2012 - Bruce Ganem, Franz and Elisa- tical Method in Medical Diagnosis. 2003 - Bruce D. Roth, Pfizer Global Re- beth Roessler Professor of Chemistry 1989 - Carl Djerassi, Stanford Univer- search & Development. The Discov- and Stephen H. Weiss Presidential Fel- sity. Synthesis and Promotion of the ery and Development of Lipitor® low at Cornell. Lost (Sometimes) In First and Most Common Birth Control (Atorvastatin Calcium). Translation: Advancing Chemical Dis- Hormone. 2004 - James W. Jorgenson, University coveries Beyond the Laboratory 1990 - Thomas J. Dougherty, Roswell of North Carolina. The Magic of Cap- 2013 - Michael H. Gelb, Harry and Park Cancer Institute. The Develop- illaries in Chemical Separations and Catherine Jaynne Bond Endowed Pro- ment of Photodynamic Therapy for the Analysis. fessor of Chemistry and Biochemistry Treatment of Malignant Disease. 2005 - Jean M. J. Fréchet, University of at the University of Washington in 1991 - Jerrold Meinwald and Thomas California at Berkeley, Functional Seattle and Frantisek Turecek, Chem- Eisner, Cornell University. Chemical Macromolecules: From Design and istry Department at University of Responses in the Insect and Plant Synthesis to Applications. Washington. The New Generation World. 2006 - Richard D. DiMarchi, University Chemistry for Newborn Screening 1992 - Bruce N. Ames, University of of Indiana, Chemical Biotechnology 2014 - David R. Walt, Robinson Profes- California at Berkeley. Methods for as a Means to Optimal Protein Ther- sor of Chemistry and Howard Hughes Detection of Carcinogens and Causes apeutics. Medical Institute Professor, Tufts of Aging and Cancer. 2007 - Michael A. Marletta, University University. Microwell Arrays: From 1993 - James G. Anderson, Harvard of California at Berkeley, Nitric Oxide Genetic Analysis to Ultra-High Sensi- University. Experimental Methods for in Biology: From Discovery to Thera- tivity Diagnostics Measuring Global Ozone Loss. peutics. 2015 - Eric Jacobsen, Sheldon Emory 1994 - Kary B. Mullis. The Discovery of 2008 - John A. Katzenellenbogen, Professor of Organic Chemistry, Har- Polymerase Chain Reactions (PCR) Swanlund Professor of Chemistry, vard University. Catalysis: A Frontier for the Replication of DNA Molecules. University of Illinois at Champaign- at the Center of Chemistry 1995 - Howard J. Schaeffer, Burroughs Urbana, Estrogens and Estrogen re- 2016 – Timothy M. Swager, John D. Wellcome Company. Nucleosides with ceptors as a Nexus of Chemistry and MacArthur Professor of Chemistry, Antiviral Activity-The Discovery of Biology in Health and Disease. MIT and Director of the Deshpande Acyclovir (Zovirax®). 2009 - Chad A. Mirkin, Director of the Center for Technological Innovation, 1996 - Roy G. Gordon, Harvard Univer- International Institute for Nanotech- Chemical/Biological Sensing: Science sity. Low Emissivity Glass; Energy nology, George B. Rathmann Professor and Real World Applications Conserving Windows. of Chemistry, Professor of Biomedical 2017 – Neil M. Donahue, Thomas Lord 1997-Rangaswamy Srinivasan, UVTech Engineering, Professor of Biological Professor of Chemistry, Chemical En- Associates. The Widely Used Laser and Chemical Engineering, Professor gineering and Engineering and Public Methodology of Tiny Focused Ablative of Medicine and Professor of Materi- Policy, Carnegie-Mellon University. Photodecomposition. als Science and Engineering, North- Atmospheric Ozonolysis: From Colli- sional Energy Transfer to Particle 1998 - Kyriacos C. Nicolaou, Scripps western University. Nanostructures in Physics and Everything in Between. Research Institute. Chemical Synthesis Chemistry, Biology, and Medicine. and Chemical Biology of Natural Sub- 2010 - Stephen L. Buchwald, Camille 2018 – Jennifer A. Doudna, Howard stances. Dreyfus Professor of Chemistry, De- Hughes Institute Investigator, Ka-shing 1999 - Robert S. Langer, Massachusetts partment of Chemistry, Massachu- Chancellor’s Chair in Biomedical and Institute of Technology. The Develop- setts Institute of Technology. Pd- and Health Sciences, Professor of Bio- ment of Unique Polymers for Medical Cu-Catalyzed Processes for the Syn- chemistry, Biophysics and Structural Applications. thesis of Pharmaceuticals. continued on page 9

8 The Nucleus April 2018 Gustavus Esselen II Continued from page 2 NESACS SENIOR CHEMISTS LUNCHEON and served as councilor and director of the national organization, during which Monday, April 30, 2018 time he was a member of the ACS Panera Bread 2pm-4pm Council Policy Committee. His chair- 1684 Massachusetts Avenue Lexington, MA manship of the national ACS meetings held in Boston in 1928 and 1939 was an outstanding service. He was on the ad- visory boards of I/EC and C&E News, 1946-48. In 1948 he received the James Flack Norris Honor Scroll as “the per- son who has done most to advance the interests of the Northeastern Section.” In 1950 he was made an honorary mem- ber of the American Institute of Chemists for his services to the profes- PHOTO COURTESY OF DORIS LEWIS sion of chemistry and chemical engi- neering. From 1919 to 1951 he was Please join us for relaxed fellowship and a chance to catch chairman of the American Section of the up with each other and with ACS news. Society of Chemical Industry. Prior to Family and friends welcome! World War II he was a reserve officer in To register contact Anna Singer [email protected] the U.S. Army’s Chemical Warfare Service. During the war he was a com- Lunch is reimbursable with receipt (up to $10). mittee chairman with the Office of Sci- entific Research and Development. Esselen’s distinguished contribu- tions to chemistry and chemical engi- neering were in accordance with the highest ethics of these professions; his recognition of the duties of a profes- sional led to his exertion of a wise and beneficent influence on all the profes- sional societies to which he gave so gen- erously of his time and led to his participation in numerous civic activities in the Boston area. Esselen was a very sensitive person, devoted throughout his life to the fine arts and music. His motto, contained on a tapestry in his office, was a quotation of Richard Wilstätter, “It is our destiny, not to create, but to unveil.” Adapted from Edward R. Atkinson, in W.D. Miles (Ed.), “American Chemists and Chemical Engineers,” American Chemical Society, Washington, DC, u 1976, p 147. Esselen Award

Continued from page 8 Biology, University of Califor-nia, Berkeley. Re-writing the Code of Life: The Impacts and Ethics of Genome u Editing

The Nucleus April 2018 9 Electronic Elections Ted Taylor Historical Notes

Continued from page 4 Continued from page 6 Continued from page 7 This process was inherently inefficient My fairway wood left me about 80 sachusetts, on October 19,1931 and was and expensive. yards short of the green on the par 5. I the son of Giuseppe and Orazio (Faro) Moreover, very few of our mem- pulled out my sand wedge and the shot Giuffrida. bers chose to respond and elections were I hit was dead on. I was jumping up and In 1955 he graduated with honors decided by less than 10 per cent of our down thinking it was going in. I ended from Boston College where he received membership. In 2017 less than 300 up with a 1-foot putt for birdie. I would his Bachelor’s Degree in Chemistry. In members voted. By switching to elec- say it was the best golf hole I ever 1957 he married Jacqueline Masuhr of tronic elections we hope to get better played and it was with Ted and a direct Haverhill, Massachusetts and they went participation in elections. We will also result of our little game of target practice on to have 3 daughters and a son. save many thousands of dollars and save at the range. John began his career in the chem- a lot of wasted paper. Ted was a remarkable organic ical industry working for Dow Chemical For several years we have chemist. I remember bumping into him Company in Midland, MI. He later re- printed and mailed less than 300 copies in San Francisco at the March 2010 turned to Massachusetts working for of the Nucleus. We intend to eventually ACS Meeting. Ted was there to receive Cabot Corporation. He retired in 1993 move to totally electronic delivery of the the Alfred Burger Award in Medicinal as a Regional Sales Manager for Cabot Nucleus. It was an anachronism to con- Chemistry from the ACS for his work on Corporation in Annandale, N.J. tinue to have to mail 6000 copies of the Alimta. The award was truly an amazing John spent his retirement years in Nucleus with candidate statements and achievement, the foundation of which the area he loved most, the Lakes Re- ballots to our membership simply be- was his earliest work on the pigments in gion of New Hampshire. He had several cause of the wording of our bylaws. butterfly wings. By the end of 2010, Al- hobbies including golf and fishing. The committee led by 2017 Chair imta stood as the most successful new Throughout his life he was also passion- Leland Johnson, Jr. that worked hard on cancer drug, based on sales, in the his- ate about cooking and everyone always revising the NESACS Bylaws deserves tory of the pharmaceutical industry. enjoyed his Italian family recipes. He a great deal of credit for working with Ted was an amazing scientist with was also known for his quick wit and National ACS to expeditiously imple- great charisma. He was an extraordinary good humor. ment this change. role model and friend. I have great John is survived by an older sister, u MPF memories of my times with Ted and will his wife, four children and seven grand- u u miss him greatly. children.

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Prof. Gonghu Li (Univ. of New Hampshire) April 12 “Surface Molecular Catalysis for Solar Fuel Re- Prof. Eric Jacobsen (Harvard) search.” “Inching toward Perfect Catalysis.” Univ. of New Hampshire, Parsons N104 Boston College, Merkert 130, 4:00 pm 11:10 am April 13 April 4 Prof. Rebekka Klausen (Johns Hopkins) Prof. Jeffery Byers (Boston College) Univ. of New Hampshire, Parsons W131 3:00 pm Tufts, Pearson, Rm. P106, 12:00 pm April 17 Prof. T Patrick Holland (Yale) “Nitrogen Fixation using Low-Coordinate Iron Prof. Joseph Barchi, Jr. (NCI) Complexes.” Tufts, Pearson, Rm. P106, 4:30 pm MIT, Room 4-370, 4:15 pm Prof. Tomislav Rovis (Columbia) Prof. Evan Miller (UCal-Berkeley) Boston College, Merkert 130, 4:00 pm “Electrophysiology, Unplugged: New Chemical Prof. Steven Suib (Univ. of Connecticut) Tools to Watch Cell Physiology.” Univ. of New Hampshire, Parsons N104 Boston College, Merkert 130, 4:00 pm 11:10 am April 5 April 18 Prof. Samie R. Jaffrey (Weill Medical College- Prof. Michael Rose (Texas) Cornell) MIT, Room 4-370, 4:15 pm Harvard, Pfizer Lecture Hall, 4:15 pm April 19 AMERICAN CHEMICAL

U.S. POSTAGE PAID Prof. Paul Chirik (Princeton) NONPROFIT ORG. NORTHEASTERN Prof. Anna Mapp (Michigan) Dartmouth, Steele, Rm 006, 10:30 am SOCIETY SECTION April 6 Harvard, Pfizer Lecture Hall, 4:15 pm Prof. Matthew Tucker (Nevada-Reno) Prof. Carolyn Bertozzi (Stanford) Boston College, Merkert 130, 4:00 pm Harvard, Pfizer Lecture Hall, 4:15 pm April 20 Prof. Hicham Fenniri (Northeastern) Prof. Jianmin Gao (Boston College) UMass-Lowell, Olney Hall, Rm 218 3:30 pm “Covalent Molecular Recognition via Imi- April 7 noboronate Chemistry.” Prof. Colin Nuckolls (Columbia) UMass-Lowell, Olney Hall, Rm 218 3:30 pm MIT, TBA April 23 Calendar April 9 Check the NESACS home page Prof. Chi Nguyen (MIT) Prof. Mike Ward (NYU) MIT, Rm 4-270, 4:00 pm for late Calendar additions: Brandeis, Gerstenzang 121, 4:00 pm Prof. Alexei Stuchebrukhov (UCal-Davis) http://www.NESACS.org Prof. J. Martin Bollinger (Penn State) Boston University, Metcalf, Rm 113, 4:00 pm MIT, TBA, 4:00 pm April 24 Note also the Chemistry Department web Prof. Corinna Schindler (Michigan) Prof. Poul Petersen (Cornell) pages for travel directions and updates. Boston University, Metcalf, Rm 113 4:00 pm These include: April 10 Tufts, Pearson, Rm. P106, 4:30 pm http://www.bc.edu/schools/cas/chemistry/s Prof. Wei Min (Columbia) eminars.html Prof. Steven Corcelli (Notre Dame) “Seeing Molecular Vibrations: Chemical Imag- http://www.bu.edu/chemistry/seminars/ “Dynamics and Vibrational Spectroscopy of Mo- ing for Biomedicine.” http://www.brandeis.edu/departments/chem lecular Reporters in Ionic Liquids.” MIT, TBA, 4:30 pm istry/events/index.html Tufts, Pearson, Rm. P106, 4:30 pm Prof. Patricia Mabrouk (Northeastern) http://chemistry.harvard.edu/calendar/upco Prof. J. Martin Bollinger (Pennsylvania State ”So You Think Your Laboratory is Running Well? ming University) When Did You Last Have a Conversation About http://www.northeastern.edu/cos/chemistry/ MIT, TBA, 4:00 pm Authorship with Your Students?” events-2/ Prof. David Thirumalai (University of Texas) Univ. of New Hampshire, Parsons N104 11:10 am http://chemistry.mit.edu/events/all MIT, TBA, 4:30 pm April 25 http://chem.tufts.edu/seminars.html Prof. Wei Min (Columbia) Prof. Louise Berben (UCal-Davis) http://engineering.tufts.edu/chbe/newsEven “Seeing Molecular Vibrations: Chemical Imag- MIT, Rm 4-370, 4:15 pm ts/seminarSeries/index.asp ing for Biomedicine.” April 26 http://www.chem.umb.edu MIT, TBA, 4:30 pm http://www.umassd.edu/cas/chemistry/ Prof. Eric Jacobsen (Harvard) Prof. Elizabeth R. Jarvo (UCal-Irvine) http://www.uml.edu/Sciences/chemistry/Se “Anion-Binding Catalysis.” MIT, Rm 6-120, 4:00 pm minars-and-Colloquia.aspx Boston College, Merkert 130, 4:00 pm Prof. Wilson Smith (Delft University) http://www.unh.edu/chemistry/events Prof. Caleb Martin (Baylor) Boston College, Merkert 130, 4:00 pm https://www.wpi.edu/academics/departmen “Exploiting the Diverse Chemistry of Boroles to April 28 ts/chemistry-biochemistry April 2 Access Unsaturated Boracycles.” Prof. Stefan Hell (Max-Planck-Institute) Univ, of New Hampshire, Parsons N104 Harvard, Pfizer Lecture Hall, 5:00 pm Prof. Karen Wooley (Texas A&M) 11:10 am April 30 Boston University, Metcalf, Rm 113 April 11 4:00 pm Prof. Eric Jacobsen (Harvard) April 3 Prof. Delia Milliron (Texas) Boston University, Metcalf, Rm 113 4:00 pm Harvard, TBA, 4:15 pm Notices for The Nucleus Prof. Taekjip Ha (Johns Hopkins) Prof. Eric Jacobsen (Harvard) MIT, Room 6-120, 4:30 pm “New Stereoselective, Catalytic Fluorination Re- Calendar of Seminars should be Prof. David Nicewicz (North Carolina-Chapel actions.” sent to: Hill) Boston College, Merkert 130, 4:00 pm Xavier Herault, email: Boston College, Merkert 130, 4:00 pm Prof. Amir Mitchell (UMass Medical School) u WPI, Gateway Park, Rm 1002, 12:00 pm [email protected]