Rapporto Annuale XXIII. 2018– 2019
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Vir Biotechnology Appoints Leading Immunologist Antonio Lanzavecchia, M.D., Senior Vice President, Senior Research Fellow
Vir Biotechnology Appoints Leading Immunologist Antonio Lanzavecchia, M.D., Senior Vice President, Senior Research Fellow December 18, 2017 SAN FRANCISCO, Calif. – December 18, 2017 – Vir Biotechnology, Inc. today announced the appointment of Antonio Lanzavecchia, M.D., as Senior Vice President and Senior Research Fellow, effective immediately. Reporting to Chief Executive Officer George Scangos, Ph.D., Dr. Lanzavecchia will provide scientific leadership for Vir’s technical programs that are designed to transform the care of people with serious infectious diseases. In addition to this role, Dr. Lanzavecchia will continue to serve as the director of the Institute for Research in Biomedicine in Bellinzona, Switzerland and as a professor in the faculty of biomedical sciences at the Università della Svizzera italiana. “Antonio is an exceptional scientist who has helped transform the field of human immunology so that exciting new approaches to tackling infectious diseases are now available,” said Dr. Scangos. “He will be instrumental in the pursuit of our strategy to integrate diverse innovations in science, technology, and medicine to create treatments that induce protective and therapeutic immune responses.” Dr. Lanzavecchia is recognized for his contributions to the development of the field of human immunology. His discoveries on antigen presentation, dendritic cell biology, and immunological memory have implications for the development of new therapeutic approaches and vaccines. Dr. Lanzavecchia’s lab at the Institute for Research in Biomedicine developed high-throughput cell-based screens to isolate potent and broadly neutralizing antibodies from human memory B cells and plasma cells. These antibodies represent candidates for passive vaccination, as well as tools for vaccine design. -
Antonio Lanzavecchia – Biosketch
Antonio Lanzavecchia – Biosketch Antonio Lanzavecchia is known for his work on antigen presentation by B cells and dendritic cells, for his studies on T cell activation and on the cellular basis of immunological memory, and for the development of novel methods to isolate human monoclonal antibodies. Lanzavecchia was born in Italy and obtained a medical degree from the University of Pavia, where he specialized in pediatrics and in infectious diseases. From 1983 to 1999 he worked at the Basel Institute for Immunology and since 2000 as founding director of the Institute for Research in Biomedicine in Bellinzona, Switzerland. He has been Professor of Immunology at the University of Genova and at the Swiss Federal Institute of Technology, ETH Zürich. Lanzavecchia received the EMBO Gold Medal, the Cloetta Prize, the Robert Koch Prize, the Sanofi-Institut Pasteur prize and the Louis-Jeantet Prize and is a member of the EMBO and a foreign associate of the US National Academy of Sciences. Lanzavecchia is the scientific Founder of Humabs Biomed, now a subsidiary of Vir Biotechnology, where he is currently Senior Research Fellow. His academic research continues at the National Institute of Molecular Genetics in Milan. Antonio Lanzavecchia – Current research interest Lanzavecchia’s laboratory investigates the mechanisms of antibody-mediated resistance to infectious diseases. Using high-throughput cellular screens, they interrogate human memory B cells and plasma cells and isolate potent and broadly neutralizing antibodies against a variety of targets, ranging from common pathogens to emerging viruses. These antibodies are developed for prophylaxis and treatment of infectious diseases and are used as tools to produce optimal vaccine components in a process of antibody-guided vaccine design. -
HTA6 R Dordea Simion.Indd
220 studies in History & Theory of Architecture Ștefan Simion Ambiguity of the Masterpiece. Livio Vacchini through 11 Dialogues Bucharest: Editura Fundației Arhitext Design, 2017, 319 pages, including illustrations, ISBN 978-606-8645-03-2 Dragoș Mihai Dordea PhD, Assistant Professor, “Ion Mincu” University of Architecture and Urbanism, Bucharest, Romania [email protected] Reviewing Ambiguity of the Masterpiece. Livio Vacchini through 11 Dialogues I discovered a work that is carefully crafted like a building following Livio Vacchini’s principles: the book is a sequence of spaces where the reader literally listens to architects and theorists confessing their friend, Livio Vacchini. Just like the hard kernel of Vacchini’s work, the content of the book is spatial and relational. It is reconstructed by the dialogues as a process, as a construction, as a construct, as a criticism, as a state of mind, a lifestyle, a credo. The tone of the discourse is also noteworthy: on the one hand, it projects the reader into the intimate space of the architect and his circle of friends, collaborators, critics, etc.; on the other hand, it urges/implies respect towards a lifetime’s work and a modus operandi that is in search of eternal perfection, all the while acknowledging the ambiguity given by the constraints of the present. The ability to underline subtle criticisms is also something that makes this book an important piece of the puzzle that is trying to understand the work of Vacchini. The precision of the narrative construction also fosters an ambiguity in the way in which the book creates both a public and a private space for the reader. -
A SARS-Like Cluster of Circulating Bat Coronaviruses Shows Potential For
Resources How To Sign in to NCBI PMC Search US National Library of Medicine National Institutes of Health Advanced Journal list Help COVID-19 Information Public health information (CDC) | Research information (NIH) SARS-CoV-2 data (NCBI) | Prevention and treatment information (HHS) | Español Journal List Nature Public Health Emergency Collection PMC4797993 Formats: Article | PubReader | ePub (beta) | PDF (963K) | Cite Share Facebook Twitter Google+ Nat Med. 2015; 21(12): 1508–1513. PMCID: PMC4797993 Published online 2015 Nov 9. doi: 10.1038/nm.3985 NIHMSID: NIHMS766724 Save items PMID: 26552008 Add to Favorites A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence Similar articles in PubMed Effects of human anti-spike protein receptor binding domain Vineet D Menachery, 1 Boyd L Yount, Jr,1 Kari Debbink,1,2 Sudhakar Agnihothram,3 Lisa E Gralinski,1 antibodies on severe acute respiratory syndrome[J Virol. 2014] Jessica A Plante,1 Rachel L Graham,1 Trevor Scobey,1 Xing-Yi Ge,4 Eric F Donaldson,1 Evolutionary Arms Race between Virus and Host Drives Scott H Randell,5,6 Antonio Lanzavecchia,7 Wayne A Marasco,8,9 Zhengli-Li Shi,4 and Ralph S Baric Genetic Diversity in Bat Severe Acute Respiratory[J Virol. 2020] 1,2 Broad Cross-Species Infection of Cultured Cells by Bat ▸ Author information ▸ Article notes ▸ Copyright and License information Disclaimer HKU2-Related Swine Acute Diarrhea Syndrome[J Virol. 2019] SARS-CoV replication and pathogenesis in an in vitro This article has been corrected. See Nat Med. 2016 April 6; 22(4): 446. model of the human conducting airway epithelium.[Virus Res. -
L'architettura Scolastica Nel Cantone Ticino, 1945–1980
italiana Svizzera della Università Moderno del Archivio Seminario a cura di Matteo Iannello L’architettura scolastica lunedì 14 maggio 2018 ore 14.00 nel Cantone Ticino, Palazzo Turconi Aula T 1.02 1945–1980 Nell’ambito del progetto FNS “L’architettura nel Cantone Ticino, 1945–1980” promosso dall’Archivio del Moderno L’architettura scolastica nel Cantone Ticino, Nell’ambito del progetto di ricerca 1945–1980 “L’architettura nel Cantone Ticino, 1945-1980”, finanziato dal FNS – Fondo Nazionale Svizzero per la Ricerca Scientifica e diretto da Nicola Navone, il 14 maggio 2018 si terrà un seminario di studio sul tema dell’architettura scolastica nel Cantone Ticino, a cura di Matteo Iannello, ricercatore post-doc FNS all’Archivio del Moderno dell’Accademia di architettura - USI. Dal dopoguerra in poi, e in particolare sino alla fine degli anni ’70, l’architettura scolastica ha rappresentato in Ticino un banco di prova ed un campo di azione privilegiato per un’intera generazione di architetti ticinesi disposti a confrontarsi – anche attraverso la pratica del concorso d’architettura – su un tema progettuale che sollecitava nuove soluzioni e offriva un ampio margine di sperimentazione sulla scorta delle istanze didattiche e sociali che si stavano affermando dopo lunga gestazione. Il seminario si propone di ricostruire le ragioni storiche, sociali e architettoniche di un fenomeno considerato nel suo insieme, anche in relazione al contesto e alle coeve esperienze svizzere ed europee. In questa prospettiva di lavoro e ricerca, il seminario è dunque un’occasione di confronto e di verifica dello stato degli studi attraverso tre relazioni di apertura, cui seguirà una tavola rotonda intesa come momento di dibattito e riflessione. -
The Territorial Imagination: Re-Visiting the Work of Luigi Snozzi (1932-2020) and the Monte Carasso Design Seminar Matthew Jones
The Territorial Imagination: Re-visiting the work of Luigi Snozzi (1932-2020) and the Monte Carasso Design Seminar Matthew Jones “There are very few architects who are capable of, or interested in, giving order to an entire territory. This is a very difficult task, because every place, even at a distance of a mere ten metres, appears completely different, suggesting different ways of intervening with architecture. How can we respond with rules to this incredible diversity of places?” Luigi Snozzi1 Like a huge number of architects in the UK and across the world, I was saddened to hear of the recent passing of Luigi Snozzi in December 2020. Snozzi was a charismatic, larger than life character with strong political beliefs that shaped his career. Concerned with architecture’s relationship with people and place he was unafraid of making radical propositions, often designing ‘counter proposals’ to reveal the inherent contradictions or flaws in competition briefs. He is perhaps best known for his relationship with the town of Monte Carasso - his successful stewardship of the town over a period of more than thirty years. This is one of only a handful of examples of successful long-term collaborations between an architect and a municipality in Europe. It remains an important example of the potential of architecture and urban design to positively transform small settlements, combining a belief in the validity of the European city with an architectural language influenced by the modern movement. The news of Snozzi’s passing took me back to my experience of attending the annual Monte Carasso Design Seminar, led by Snozzi, which I attended fifteen years ago. -
UN DIALOGO ININTERROTTO Studi Su Flora Ruchat-Roncati
UN DIALOGO ININTERROTTO. STUDI SU FLORA RUCHAT-RONCATI STUDI SU FLORA ININTERROTTO. UN DIALOGO Serena Maffioletti, laureata in Architettura presso il Politecnico di Milano e dottore di ricerca, Flora Ruchat-Roncati (Mendrisio, 1937 - Zurigo, 2012) è stata una delle più rilevanti è professore ordinario di Composizione architettonica e urbana presso l’Università Iuav di Venezia; e innovative progettiste della storia recente, prima donna a ricoprire dal 2012 è responsabile scientifico dell’Archivio Progetti Iuav. Progettista e capogruppo di numerosi il ruolo di professore ordinario presso il Politecnico di Zurigo, dove tenne la cattedra progetti, pubblicati, esposti in mostre e riconosciuti con premi. L’attività, che riunisce teoria, di Progettazione architettonica dal 1985 al 2002. ricerca progettuale, didattica e indagine critica, è rivolta principalmente a questi temi: rapporto Ugualmente partecipe della cultura architettonica italiana e svizzera, fu costantemente del progetto con luoghi e tradizioni in particolare del Moderno; tradizioni e innovazioni dell’abitare la città e il territorio; progetti in luoghi della storia e in aree archeologiche; progetto infrastrutturale incline a varcare i confini: i confini fisici, quelli del Gottardo per muoversi tra Zurigo nei paesaggi contemporanei; architetture della metropoli. Ha dedicato molti studi all’architettura UN DIALOGO ININTERROttO e l’Italia; i confini della disciplina architettonica, accordandola al mondo dell’ingegneria razionalista italiana e internazionale, tra i quali si evidenziano le ricerche sui BBPR, in particolare infrastrutturale e del progetto ambientale e paesaggistico; i confini professionali, le edizioni critiche degli scritti di Ernesto N. Rogers, Architettura, misura e grandezza dell’uomo Studi su Flora Ruchat-Roncati come donna che ha affermato il proprio ruolo fuori e dentro le aule universitarie. -
Acceptance Speech by Antonio Lanzavecchia I Am Deeply
Acceptance Speech by Antonio Lanzavecchia I am deeply honoured and humbled by receiving this prestigious prize from the Robert Koch Foundation and I am especially happy to share it with my friend and colleague Rafi Ahmed. When I trained in infectious diseases at the University of Pavia, I never dreamed that I would be standing here at this ceremony, which honours the legacy of one of the Founders of this field. This award recognizes the work performed over many years with a fantastic group of talented scientists with whom I have had the opportunity to interact. There are many to acknowledge and thank, in particular those who fostered the start of my career, Franco Celada who offered me my first laboratory bench in Genova as well as advice for my transition from the clinic to basic research and Fritz Melchers who offered me the possibility to work at the Basel Institute on a project focusing on human immunology. I remember that there was not a general consensus around this concept and Fritz asked me to explain why I wanted to study the immune system in humans. This was indeed the title of my promotion seminar at the Basel Institute, which luckily was successful. This experience has taught me the importance to give freedom and space to young fellows that want to pursue their own ideas. I started to work with cells with the notion that looking at lymphocyte behaviour in vitro might illuminate on certain aspects of their function in vivo. I was looking at T cells growing in culture very much like Robert Koch was looking at bacteria growing in hanging-drops. -
Institute for Research in Biomedicine Annual Report 2003
Institute for Research in Biomedicine Annual Report 2003 TABLE OF CONTENTS TABLE OF CONTENTS Page n. STAFF 5-6 SCIENTIFIC ADVISORY BOARD 7 RESEARCH REPORTS 8-31 1. Protein folding and quality control in the endoplasmic reticulum 8 2. The role of ER lectins in ER-associated protein degradation (ERAD) 8 3. Folding, quality control and degradation of secretory proteins in cells depleted of the transcription factor Xbp1 9 4. Kifunensine affects differentiation of B cells into plasma cells 9 5. Protein aggregation as an intermediate step in ERAD 10 6. The role of UDP-glucose: glycoprotein glucosyltransferase (GT) in glycoprotein quality control 10 7. The role of the ER-resident oxidoreductase ERp57 in oxidative glycoprotein folding 11 8. An unfolded protein response to down-regulation of Cnx and ERp57 decides on cell death or adaptation 11 9. An alternative approach to regulate proteolytic processing of the amyloid precursor protein and inhibit the generation of the amyloid-beta peptide in vivo 11 10. Regulation of the inflammatory transcription factor NF-kB in vivo 12 11. Transcriptional repression and termination in the inflammatory response 13 12. CCR2-induced RhoGTPase activation 13 13. Cellular functions of the class II HsPI3K-C2α 13 14. Characterization of the putative chemokine receptor RDC1 14 15. Chemokine receptor mediated signal transduction 14 16. Stimulation of chemotaxis by the chemokine receptor CXCR4 14 17. The role of Z gene product in T cell development and function 15 18. The role of a novel home box containing transcription factor in lymphoid cells 15 19. The function of Lag 3 in immunecytes of non T cell origin 15 20. -
Phenotype and Specificity of T Cells in Primary
Research Collection Journal Article Phenotype and specificity of T cells in primary human cytomegalovirus infection during pregnancy: IL-7Rpos long-term memory phenotype is associated with protection from vertical transmission Author(s): Mele, Federico; Fornara, Chiara; Jarrossay, David; Furione, Milena; Arossa, Alessia; Spinillo, Arsenio; Lanzavecchia, Antonio; Gerna, Giuseppe; Sallusto, Federica; Lilleri, Daniele Publication Date: 2017 Permanent Link: https://doi.org/10.3929/ethz-b-000211954 Originally published in: PLoS ONE 12(11), http://doi.org/10.1371/journal.pone.0187731 Rights / License: Creative Commons Attribution 4.0 International This page was generated automatically upon download from the ETH Zurich Research Collection. For more information please consult the Terms of use. ETH Library RESEARCH ARTICLE Phenotype and specificity of T cells in primary human cytomegalovirus infection during pregnancy: IL-7Rpos long-term memory phenotype is associated with protection from vertical transmission Federico Mele1, Chiara Fornara2, David Jarrossay3, Milena Furione4, Alessia Arossa5, a1111111111 Arsenio Spinillo5, Antonio Lanzavecchia3, Giuseppe Gerna2, Federica Sallusto1,6*, a1111111111 Daniele Lilleri2* a1111111111 a1111111111 1 Center of Medical Immunology, Institute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland, 2 Laboratori Sperimentali di Ricerca-Area Trapiantologica and Area Biotecnologie, a1111111111 Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, 3 Immune Regulation Laboratory, -
Livio Vacchini, Scuola Ai Saleggi Di Locarno, 1970–1979
Coordinamento editoriale Elenco studenti Tiziano Casartelli Corso Corso Progetto grafico e impaginazione Restoration and Reuse 20th Century th Livio Vacchini, Scuola Alberto Canepa of the 20 Century Heritage Architectural Heritage MSc1, aa 2016-2017 MSc1, aa 2019-2020 © 2020 Riccardo Altobello Daniel Aeschbacher Accademia Andrea Bacchi Mellini Giulia Anserini ai Saleggi di Locarno, di architettura Benjamin Barrera Moritz B. Büchsel Mendrisio Laura Bonalume Simon Bohnet Università Giacomo Bonesi Luca Borlenghi della Svizzera Guido Brioschi Malinverni Marco Brighenti italiana Anna Callegaro Emanuele Carcano 1970–1979 Silvia Capello Charlotte Decollogny Federica Caruso Zhiying Deng Gemma Carzaniga Simone Fagini Genesi, trasformazioni e salvaguardia Ecaterina Cazan Costanza Favero Federica Chea Cesare Fedrizzi Martina Ciet Amy Rose Frederick di un’architettura esemplare Filippo Cocco Fabio Gandolla Nicholas Compagnoni Costanza Giordano Anna Dalla Costa Andreas Hellum Camilla Dandrea Patrick Hennerici Alberto De Lorenzo Patrik Honegger Roberta Grignolo Giulia Donati Federico Mantl Mattia Fornoni Silvia Marrocco Marco Di Nallo Luca Forzi Michelangelo Morandi Christopher Fraquelli Daria Moatazed-Keivani Arnaud Froment Lukasz Palczynski Marco Ghezzi Luke Peppard Ludovica Giangrossi Soline Quénet Valentin Goetze Nele Riecks Piero Armando Graziani Lobato Valentina Roberto Naomi Guastini Michal Rogucki Flavio Guidi Matteo Rossi Nadinka Guscetti Jasper Rumbelow Walter Hjaltested Melanie Schlanser Tuuli Kanerva Niklas Schmitz Costanza La Greca Moritz Schnettler Domizia Lantin Shiyun Sun Olivia Lillus Wei Sun Leo Lindroos Anna Török Lucia Macrì Trine Tryggestad Berre Chiara Malerba Robbe Vandewyngaerde Stefano Marzo Jurij von Aster Gloria Mazzucchelli Benedict Wahlbrink Hannah Mcdorman Lisa Munerato Stephen Okoh Gabriele Pagani Marco Pederzini Claudia Pescia Jordan Maurice Pol Selin Samci Claudia Soricelli Giorgio Turri Guido Vandelli Gonçalo Vilhena Serafina Wojciechowska Mendrisio Academy Press Sommario 0. -
Bellinzona Bellinzona Is Probably Switzerland's Most Italianate Town
Bellinzona Bellinzona is probably Switzerland's most Italianate town. The skyline of the capital of Ticino is defined by the powerful fortifications, comprising three of the best-preserved medieval castles in Switzerland, which are listed as a UNESCO World Heritage Site. Bellinzona Turismo Palazzo Civico – Piazza Nosetto 6501 Bellinzona T +41 (0)91 825 21 31 F +41 (0)91 821 41 20 [email protected] http://www.bellinzonaturismo.ch 200 m 1000 ft Bellinzona (German: Bellenz) is strategically positioned where the valley narrows on the way to the Alpine passes of St. Gotthard, San Bernardino and Lucomagno (Lukmanier). The town acts as a gateway to Italy for those travelling from the North, and the keyhole to the Alps for those coming from the South. The picturesque corners and squares, the courtyards and the neo-Classical, Italian-style theatre, and the sympathetically restored old houses tell visitors the history of what is culturally a Lombardy town. In its alleyways are richly decorated patrician houses and beautiful churches. Yet behind the austere charm of the medieval town is all the dynamic life of a modern meeting-place. Numerous boutiques, cafés and specialist shops offering culinary delicacies invite you to linger and window- shop. Each Saturday there is a big weekly market on the Piazza Nosetto. © MySwitzerland.com - Schweiz Tourismus - Page 1/12 General Info The fortifications of Bellinzona are among the most important examples of medieval defensive Canton: Ticino architecture in the Alps, and have been listed as a UNESCO World Heritage Site since the year Postcode/ZIP: 6500 - 6501 2000.