Antonio Lanzavecchia – Biosketch

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Antonio Lanzavecchia – Biosketch Antonio Lanzavecchia is known for his work on antigen presentation by B cells and dendritic cells, for his studies on T cell activation and on the cellular basis of immunological memory, and for the development of novel methods to isolate human monoclonal antibodies. Lanzavecchia was born in Italy and obtained a medical degree from the University of Pavia, where he specialized in pediatrics and in infectious diseases. From 1983 to 1999 he worked at the Basel Institute for Immunology and since 2000 as founding director of the Institute for Research in Biomedicine in Bellinzona, Switzerland. He has been Professor of Immunology at the University of Genova and at the Swiss Federal Institute of Technology, ETH Zürich. Lanzavecchia received the EMBO Gold Medal, the Cloetta Prize, the Robert Koch Prize, the Sanofi-Institut Pasteur prize and the Louis-Jeantet Prize and is a member of the EMBO and a foreign associate of the US National Academy of Sciences. Lanzavecchia is the scientific Founder of Humabs Biomed, now a subsidiary of Vir Biotechnology, where he is currently Senior Research Fellow. His academic research continues at the National Institute of Molecular Genetics in Milan. Antonio Lanzavecchia – Current research interest Lanzavecchia’s laboratory investigates the mechanisms of antibody-mediated resistance to infectious diseases. Using high-throughput cellular screens, they interrogate human memory B cells and plasma cells and isolate potent and broadly neutralizing antibodies against a variety of targets, ranging from common pathogens to emerging viruses. These antibodies are developed for prophylaxis and treatment of infectious diseases and are used as tools to produce optimal vaccine components in a process of antibody-guided vaccine design. Besides these translational studies, the laboratory addresses fundamental aspects of the antibody response, such as the mechanisms that lead to the production broadly neutralizing antibodies, and the relationship between infection and autoimmunity. The laboratory is also studying a new mechanism of antibody diversification through templated DNA insertions that they recently discovered in the context of the antibody response to malaria parasites. .

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Vir Biotechnology Appoints Leading Immunologist Antonio Lanzavecchia, M.D., Senior Vice President, Senior Research Fellow
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M9 S 62 L 87 Utajärvi 6 M4 Rosenön, Stockholm Niagara Falls 6 8 4 M S Edimburgh S52 L 8 5 Z28 Z29 L 81 29 31 L65 S 46 37 35 J 39/40 4 L6 L79 J35 Z2 G 6 16 16 Warrenton 11 Saxton River 2 Boston 38 Athens/Vari N.Haven L 76 Tokyo N.Y. Chantilly S 55 Snowbird Rockville 40 Keystone Bethesda Rehovot Stanford Washington Z 24 San Diego Albuquerque La Jolla Indian Wells Dallas Alabama 1 S 9 4 7 Austin Houston Z 22 13 J36 Annual Report 17 Z 20 S 51 L 6 9 Z 2006 23 1 Institute for Research in Biomedicine, Istituto di Ricerca in Biomedicina HCMC 28 L 88 Z21 Armidale Melbourne M9 S 62 L 87 Utajärvi 6 M4 Rosenön, Stockholm Niagara Falls 6 8 4 M S Edimburgh S52 L 8 5 Z28 Z29 L 81 2 Foreword / Giorgio Noseda, President of the Foundation Council Table of Contents 4 Introduction / Professor Antonio Lanzavecchia, Director 6 Cultivating Discovery 29 8 Advancing Discovery 10 Teaching Discovery 31 6 L65 12 Focusing Discovery S 4 14 SHAPING PROTEINS / Protein Folding and Quality Control / Maurizio Molinari 37 35 J 39/40 16 SIGNAL TRANSDUCTION / Cell Migration Chemokine Receptors / Marcus Thelen 18 DEVELOPMENT / T Cell Development / Fabio Grassi L64 L 79 20 STEM CELLS / Haematopoiesis / Markus Manz J35 Z2 G 6 22 HIV-AIDS / Viral Replication, Pathogenesis and Immunity / Jeremy Luban 1 6 16 24 INFLAMMATION / Chemokine Activities / Mariagrazia Uguccioni 26 IMMUNITY / Cellular Immunology / Federica Sallusto 28 ANALYTIC VACCINOLOGY / Immune Regulation / Antonio Lanzavecchia Warrenton 11 32 Overview / Science at the Institute & Life in the Institute Saxton River 2 38 Athens/Vari 34 Multiplying Discovery Boston 36 • Education PhD Programme and PhD Students N.Haven L 76 Tokyo 39 • Lectures and seminars given by IRB Scientists in 2006 N.Y.
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