Myo-Inositol, Probiotics, and Micronutrient Supplementation
Diabetes Care Volume 44, May 2021 1091 Myo-Inositol, Probiotics, and Keith M. Godfrey,1,2 Sheila J. Barton,1 Sarah El-Heis,1 Timothy Kenealy,3 Micronutrient Supplementation Heidi Nield,1 Philip N. Baker,4 Yap Seng Chong,5,6 Wayne Cutfield,3,7 From Preconception for Glycemia Shiao-Yng Chan,5,6 and NiPPeR Study Group* in Pregnancy: NiPPeR International Multicenter Double-Blind Randomized Controlled Trial Diabetes Care 2021;44:1091–1099 | https://doi.org/10.2337/dc20-2515 OBJECTIVE Better preconception metabolic and nutritional health are hypothesized to pro- mote gestational normoglycemia and reduce preterm birth, but evidence sup- 1MRC Lifecourse Epidemiology Unit, University porting improved outcomes with nutritional supplementation starting of Southampton, Southampton, U.K. CLIN CARE/EDUCATION/NUTRITION/PSYCHOSOCIAL preconception is limited. 2NIHR Southampton Biomedical Research Centre, University Hospital Southampton, NHS RESEARCH DESIGN AND METHODS Foundation Trust, Southampton, Southampton, U.K. This double-blind randomized controlled trial recruited from the community 3Liggins Institute, University of Auckland, 1,729 U.K., Singapore, and New Zealand women aged 18–38 years planning con- Auckland, New Zealand 4 ception. We investigated whether a nutritional formulation containing myo-inosi- College of Life Sciences, Biological Sciences and Psychology, University of Leicester, tol, probiotics, and multiple micronutrients (intervention), compared with a Leicester, U.K. standard micronutrient supplement (control), taken preconception and through- 5Department of Obstetrics and Gynaecology, out pregnancy could improve pregnancy outcomes. The primary outcome was Yong Loo Lin School of Medicine, National combined fasting, 1-h, and 2-h postload glycemia (28 weeks’ gestation oral glu- University of Singapore and National University Health System, Singapore cose tolerance test).
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