Supplementary material Ann Rheum Dis

Bone Marrow-Derived CD34+ cells from 'Sle.Female Patients vs Healthy.Female Donors' (|FC|1.5, FDR<0.05) Gene name logFC logCPM LR PValue FDR COL1A1 -7.783555039 6.807948902 105.2890103 1.0556E-24 1.88393E-20 COL1A2 -6.171009777 6.297502952 51.59612708 6.81759E-13 6.08368E-09 LINC00926 -3.425625643 4.621795357 45.20797906 1.77182E-11 1.05405E-07 SLC1A7 -5.739061727 -1.873836966 37.23229183 1.04863E-09 4.67872E-06 GNLY -4.550123694 4.959247236 32.27531241 1.33803E-08 4.07216E-05 COL6A2 -2.661472883 3.98262692 31.71192942 1.7882E-08 4.07216E-05 MYBL1 -3.098929193 3.266745415 31.67503801 1.8225E-08 4.07216E-05 PF4V1 -4.829460868 3.456100153 31.55971105 1.93401E-08 4.07216E-05 CHAD -3.682939822 1.489866302 31.44326474 2.05354E-08 4.07216E-05 SEMA5A -5.237303552 0.029311815 31.14853681 2.39019E-08 4.26578E-05 BANK1 -2.525501239 5.664650031 30.61471378 3.14698E-08 5.10583E-05 EML6 -2.790461194 3.052626974 30.00141922 4.3173E-08 6.42091E-05 BMP3 -5.70889881 0.40719158 29.09759906 6.88222E-08 9.44823E-05 ZNF683 -4.551465428 0.922803558 28.15067825 1.12228E-07 0.000143067 FCER2 -2.985682471 2.351723102 25.62743279 4.1411E-07 0.000492708 PRSS23 -2.932491066 1.977294958 24.79076972 6.39027E-07 0.000706438 B3GAT1 -4.108384954 0.288279346 24.69118999 6.72911E-07 0.000706438 CHRNA2 -4.109971692 1.756332608 24.37074336 7.94664E-07 0.00078791 RAMP3 -4.778158161 2.49449499 24.22766171 8.55941E-07 0.000803999 CDHR3 -4.804214053 -0.586993167 24.0953193 9.16829E-07 0.000818132 CDH15 -4.209004979 -1.158267325 23.29288277 1.39114E-06 0.001119477 NFATC4 -2.973596063 1.26784954 23.27360628 1.40515E-06 0.001119477 PLCH2 -3.362229474 2.049290953 23.11783731 1.52371E-06 0.001119477 PRKCG -3.719676026 -1.125375997 23.08003487 1.55396E-06 0.001119477 IL12RB2 2.739935292 4.295646421 22.99615574 1.62326E-06 0.001119477 RASAL1 -4.62295634 0.642948189 22.98714266 1.63088E-06 0.001119477 MYO3A -4.874113595 -2.146246618 22.86522286 1.73768E-06 0.001131571 FUNDC2P2 -6.630545848 -2.664838955 22.76547388 1.83024E-06 0.001131571 ROR1 -4.039715176 -1.333058825 22.71673608 1.87726E-06 0.001131571 IKZF3 -3.481444988 4.118303532 22.69145306 1.90212E-06 0.001131571 TNFRSF13C -2.952505037 2.153230869 22.5242357 2.07509E-06 0.001168075 PROX1 -5.801496893 -2.283905094 22.50646062 2.09438E-06 0.001168075 DUSP8 -3.36950857 1.503366136 22.36059577 2.25963E-06 0.001222048 HGF 2.317265393 5.119296562 22.08687095 2.60586E-06 0.001367846 TBX21 -3.691187502 2.166670279 21.96696708 2.77384E-06 0.001414419 PEG10 -3.937784075 1.130357219 21.86990061 2.91775E-06 0.001446474 PRF1 -3.424784051 4.152519847 21.71834046 3.15758E-06 0.001510349 TSPYL2 -1.735509454 5.957734409 21.57338095 3.40546E-06 0.001510349 MIR378I -2.955264611 -0.138057755 21.5524929 3.44275E-06 0.001510349 NMUR1 -3.101724947 1.014206031 21.53962563 3.46593E-06 0.001510349 ZNF365 -4.394702806 -0.555464426 21.53751983 3.46973E-06 0.001510349 LOC339862 8.073309703 0.649792475 21.40526808 3.71748E-06 0.001579665 FGFBP2 -3.793215027 2.648232161 21.30832658 3.91029E-06 0.001622954 COL19A1 -4.74237519 0.991960166 21.23412428 4.06463E-06 0.00164867 MS4A1 -3.781701734 5.581634025 20.98978397 4.61739E-06 0.001818844 CTTN -3.059739138 6.651853017 20.93538199 4.75039E-06 0.001818844 FCRL3 -4.169144684 2.853695546 20.91950701 4.78992E-06 0.001818844

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

MDM1 -1.674103801 6.265350757 20.8660647 4.92544E-06 0.00183134 ITPKB -1.689843315 6.260344445 20.67315048 5.44745E-06 0.001984096 C15orf52 -2.190978921 5.005076224 20.53014272 5.86996E-06 0.002095222 COL13A1 -5.329088942 -1.367454143 20.42330735 6.20692E-06 0.002150255 NBPF15 -2.558491003 2.362329638 20.40545363 6.2651E-06 0.002150255 PDZD4 -3.677589754 2.415113811 20.29553304 6.63553E-06 0.002221201 LOC100129973 -3.19508909 0.890799482 20.2711236 6.72073E-06 0.002221201 GZMH -4.015328586 2.802823968 20.1965574 6.98786E-06 0.002267496 LINC00494 -3.647518409 0.64539626 19.84213503 8.41081E-06 0.002641004 NCR3 -2.971892414 0.660488406 19.83667313 8.43487E-06 0.002641004 ALOX12 -2.466070116 5.339478818 19.7799544 8.68892E-06 0.00267364 NDNL2 -1.747363144 4.740729846 19.66956224 9.2056E-06 0.002784617 PYHIN1 -3.548590346 2.015229741 19.50472243 1.00351E-05 0.002885862 OR7A5 -4.26670234 -0.443120272 19.45454282 1.03023E-05 0.002885862 SLC27A6 7.289125602 0.049362794 19.42979556 1.04366E-05 0.002885862 PLCG1 -1.975154646 5.223519532 19.42664322 1.04538E-05 0.002885862 IRF4 -2.801993164 5.215352451 19.40412663 1.05778E-05 0.002885862 LAT -2.412226767 6.174090248 19.3960497 1.06227E-05 0.002885862 ANKRD30B -5.23764821 -2.269791091 19.36705492 1.07852E-05 0.002885862 MYBPC2 -2.889735425 -0.701421766 19.35844496 1.08339E-05 0.002885862 LINC01588 -3.096390366 1.218301238 19.24976308 1.14685E-05 0.003009965 FAM102A -2.093306829 4.680902337 19.19506986 1.18018E-05 0.003052363 RGS9 -3.461757785 0.968301019 19.16772413 1.19721E-05 0.003052363 ZNF831 -3.49312615 2.50454107 19.08729741 1.24873E-05 0.003114213 CD247 -3.522006994 3.596359401 19.07566937 1.25636E-05 0.003114213 LINC00377 -4.515787672 -2.417949807 18.97458061 1.32472E-05 0.003238658 ARL4C -2.263248559 6.196650409 18.69409693 1.53457E-05 0.003666238 BLK -3.359709559 3.534024458 18.68649909 1.5407E-05 0.003666238 SPTBN5 -2.744671969 1.983148496 18.62046839 1.59499E-05 0.003745495 PCOLCE -2.748249833 2.424609309 18.57233375 1.63577E-05 0.003791385 MECOM 2.931335783 4.185467839 18.4887316 1.70912E-05 0.003910594 CCDC92 -1.763423706 4.789172255 18.45780616 1.73708E-05 0.003924258 MIR4697HG -3.105109133 1.814192656 18.37808236 1.8113E-05 0.004010714 SMTN -1.999033916 4.974989388 18.36864019 1.82029E-05 0.004010714 SIDT1 -1.839722123 4.113630665 18.28965345 1.89735E-05 0.004043046 NEXN -2.659630769 4.855653804 18.28626251 1.90073E-05 0.004043046 ASAP2 -2.057859281 5.507765908 18.28405835 1.90293E-05 0.004043046 KLHL31 7.176711797 -0.275373704 18.17548249 2.01456E-05 0.004221914 KLHL14 -3.465069201 1.679043891 18.15259601 2.03891E-05 0.004221914 VEGFC -3.12165981 2.368978247 18.12119066 2.07282E-05 0.004221914 LINC01515 5.136633906 0.46567113 18.11301054 2.08174E-05 0.004221914 ATP13A4 -3.191307043 2.81401811 18.03116018 2.17319E-05 0.004357848 RASA3 -1.735085246 6.716744243 17.99975892 2.20933E-05 0.0043811 TGFBR3 -2.849075818 3.573523848 17.95627945 2.26037E-05 0.004433067 CLIC3 -2.78383072 0.705058453 17.92413065 2.29888E-05 0.004459574 MIAT -2.670916648 5.641785905 17.78617883 2.47172E-05 0.004743315 SPOCK2 -3.174474269 5.597972132 17.6617751 2.63877E-05 0.005010005 LOC101929125 -4.107240653 -0.705001296 17.6346692 2.67664E-05 0.005023754 SNCA -1.647117615 6.084915133 17.60130513 2.72401E-05 0.005023754 CHI3L2 -2.872277114 0.832877595 17.56119001 2.78209E-05 0.005023754 KIAA1407 -1.75374272 3.567051094 17.52441678 2.83642E-05 0.005023754

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

DNM3 -2.564681489 5.55200133 17.51982592 2.84327E-05 0.005023754 ALS2CL -2.125990855 3.375677547 17.51677609 2.84784E-05 0.005023754 C1orf95 -2.854280961 2.707968035 17.50567903 2.86451E-05 0.005023754 SLC35D3 -3.260366451 3.001945043 17.50124278 2.8712E-05 0.005023754 ADAMTS17 -3.140720227 0.181698234 17.47151729 2.91644E-05 0.005053378 FCRLA -2.690625782 2.856370354 17.36106075 3.09094E-05 0.005288892 NETO1 -4.823124443 -1.282012996 17.34061328 3.12438E-05 0.005288892 IL21R -3.066975475 1.824282859 17.3303652 3.14127E-05 0.005288892 S1PR5 -3.726083572 2.271746216 17.30800081 3.17846E-05 0.005301489 DAAM1 -2.022641248 6.530945031 17.22538356 3.31971E-05 0.005485821 DNAAF3 -3.156557524 2.107632268 17.19756526 3.36868E-05 0.00551567 APBB2 -2.186274075 2.677012184 17.16194121 3.43245E-05 0.005568991 FYN -1.709948973 6.084316456 17.12204004 3.50532E-05 0.005578338 VSIG2 -2.725861634 3.061089488 17.11625737 3.516E-05 0.005578338 EYA1 -3.757763414 -0.39976954 17.10764833 3.53198E-05 0.005578338 RORA -3.061343245 4.34597913 17.04528917 3.64988E-05 0.005713984 SERPINE1 -3.200236954 5.269219266 16.98864727 3.7604E-05 0.005730792 PRRT2 -2.736551412 0.878302448 16.97530919 3.78691E-05 0.005730792 XYLT2 -1.856016685 5.135154352 16.97489536 3.78774E-05 0.005730792 BCL9L -2.001573929 5.105764248 16.97423172 3.78906E-05 0.005730792 RHD -3.209765063 3.005200395 16.95236647 3.83295E-05 0.00574846 INHBA-AS1 -3.472547539 1.116304598 16.90933735 3.92082E-05 0.005816822 GNAZ -2.963628425 5.218404855 16.89828569 3.94372E-05 0.005816822 MARK1 -3.69814587 -1.397414216 16.83843251 4.07006E-05 0.005929487 BIRC3 -1.845710156 5.728491879 16.83076005 4.08655E-05 0.005929487 GP9 -2.957026874 5.778547467 16.79317033 4.16831E-05 0.005999334 CD6 -3.261089291 4.267213679 16.73281278 4.30303E-05 0.006100223 TC2N -2.141758697 5.502263772 16.72636142 4.31769E-05 0.006100223 CPE -3.926497019 0.09691135 16.70161307 4.37438E-05 0.006100223 PARP15 -1.89305251 5.300731916 16.7012896 4.37512E-05 0.006100223 PRKCA -2.030823907 4.622774157 16.61700251 4.57391E-05 0.006245472 CDCP1 2.84457411 3.489482648 16.61585704 4.57668E-05 0.006245472 EXOC3L4 -2.776349754 3.145685503 16.6102646 4.59019E-05 0.006245472 CAMK2D -2.143379717 3.394324612 16.59558133 4.62587E-05 0.006245472 ADAM12 -2.867938447 -0.005684569 16.58397173 4.65427E-05 0.006245472 CBLN3 -2.822449949 0.992896065 16.55676495 4.72152E-05 0.006288437 GNB5 -2.030220931 5.509333141 16.45555316 4.98041E-05 0.006584099 MYO3B -3.430052643 -1.324071464 16.34252158 5.28644E-05 0.00693728 OSBPL10 -2.663354409 1.780451879 16.27020899 5.49207E-05 0.00715452 SLAMF6 -2.683398316 2.774387835 16.17822721 5.7653E-05 0.007456034 THCAT158 -3.300120998 1.47748466 16.158868 5.82452E-05 0.007468928 DEPTOR 2.096088496 5.038047127 16.13748019 5.89067E-05 0.007468928 BAIAP3 -2.671267475 2.831313073 16.12378936 5.9334E-05 0.007468928 JAM3 -1.741569314 4.550297964 16.12083438 5.94267E-05 0.007468928 ITPR3 -1.735704781 5.569168563 16.05996458 6.13678E-05 0.007658963 CALD1 -3.067642324 5.945885104 15.99186274 6.36153E-05 0.00783608 PDGFA -3.251023657 2.585881306 15.98469117 6.38568E-05 0.00783608 CARNS1 -2.346671589 2.442259739 15.97736991 6.41042E-05 0.00783608 JCHAIN -2.905802418 8.575014981 15.83614555 6.90704E-05 0.008385709 CD7 -2.253071698 3.365509258 15.80137489 7.03514E-05 0.00846657 ANGPTL1 -3.187870727 -1.120077024 15.77149686 7.14712E-05 0.00846657

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

COL4A3 -2.996914316 1.661546223 15.76659767 7.16565E-05 0.00846657 FAM150B -3.150859357 0.935492289 15.76648955 7.16606E-05 0.00846657 LDLRAP1 -1.45385414 5.224320492 15.75470437 7.21084E-05 0.00846657 LINC00565 -3.500397832 0.065088356 15.73814039 7.27426E-05 0.008485205 FAM46C -1.566496721 6.047595318 15.71372298 7.36876E-05 0.008539629 CXCR5 -3.912171757 1.707742262 15.62122684 7.7381E-05 0.008898929 F2RL3 -2.842182 3.924846225 15.61137562 7.77852E-05 0.008898929 BGLAP -3.096245682 -0.793664351 15.54272965 8.06612E-05 0.00916918 COLCA1 -3.808261143 -1.521878447 15.51192416 8.19864E-05 0.009260835 EDAR -4.171773917 0.375617522 15.43157119 8.55471E-05 0.009602256 TGFB1I1 -2.354612961 4.235624484 15.38643842 8.76149E-05 0.009772889 SH2D2A -2.49615159 2.232011308 15.23638882 9.48579E-05 0.01027292 FAXDC2 -2.328988334 5.354267997 15.21263469 9.60586E-05 0.01027292 ANO9 -2.072772476 4.05594893 15.21251858 9.60645E-05 0.01027292 FAM19A1 -4.99934185 -2.647681908 15.21167536 9.61074E-05 0.01027292 PDZK1IP1 -2.797515724 2.545166517 15.2035091 9.65239E-05 0.01027292 PTN -3.336067155 -1.498226205 15.1879605 9.73219E-05 0.01027292 CNR2 -2.495294043 0.564075852 15.18521117 9.74637E-05 0.01027292 GSAP -1.522159259 5.798165315 15.17954852 9.77565E-05 0.01027292 TNFSF9 -2.546745214 0.414656014 15.17810099 9.78314E-05 0.01027292 INPP5A -1.541967296 4.816005085 15.17766958 9.78538E-05 0.01027292 SYTL4 -1.913149985 4.92764205 15.16040981 9.87524E-05 0.010306627 MYLK -2.193060808 6.013797261 15.13841276 9.99096E-05 0.010366783 PCSK2 -4.702403215 0.019937191 15.12509122 0.000100617 0.010379842 BGN -3.243950468 1.461835875 15.09006775 0.000102501 0.010506841 CALN1 2.016925121 5.278173257 15.07786348 0.000103166 0.010506841 PLXNA4 -2.382721167 2.793200013 15.06967993 0.000103614 0.010506841 PIK3IP1 -1.959726071 5.495763494 15.0442376 0.00010502 0.010520791 MRVI1 -2.592718887 4.920043031 15.04163952 0.000105165 0.010520791 TSPAN33 -1.98799838 5.897188141 15.0313689 0.000105739 0.010520791 ADGB -3.595654231 -2.055093393 15.01527407 0.000106645 0.010520791 ACVR2A -2.062071896 2.782164956 15.01430438 0.000106699 0.010520791 ENO2 -1.429644344 4.771964163 14.99696258 0.000107684 0.010559576 ADCY6 -2.246767558 6.906388051 14.97518255 0.000108934 0.010623788 TTC16 -3.933392908 0.831612199 14.94672716 0.00011059 0.010726603 PTPRG -2.884289458 0.965250552 14.93243962 0.00011143 0.010749718 CDHR1 -3.04482004 0.951093273 14.87862287 0.000114655 0.011001328 SPOCK3 3.373714866 1.48525828 14.84991589 0.000116413 0.011083698 CD3E -3.373259526 4.169315481 14.84437925 0.000116755 0.011083698 WNT16 -3.003533334 -1.195980128 14.74173779 0.000123287 0.011627439 LINC00472 -3.141568159 0.355379526 14.71942174 0.000124755 0.011627439 BDNF -3.104047585 2.451066311 14.71174087 0.000125264 0.011627439 COL5A2 -2.699136228 1.841922359 14.70977523 0.000125395 0.011627439 PLIN1 -2.809750143 -0.291788453 14.70457722 0.000125741 0.011627439 LOC101927572 6.536005378 -0.946848723 14.68864272 0.000126808 0.011665695 SLC10A5 4.768551177 0.088911677 14.67883131 0.00012747 0.011666436 VIL1 -3.041558502 0.69461873 14.64269529 0.000129937 0.011831583 CNTNAP2 -3.154824418 0.465320711 14.61652427 0.000131754 0.011879059 DMTN -2.228295219 5.918357554 14.61601403 0.00013179 0.011879059 UBASH3B -1.455522068 6.178970106 14.58596195 0.000133908 0.011915138 IL24 -3.088476822 -0.454184715 14.58179383 0.000134205 0.011915138

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

GPRIN3 -2.437501391 3.460103367 14.57782475 0.000134488 0.011915138 CLEC1B -2.585334389 4.618828619 14.5726095 0.000134861 0.011915138 ARHGAP18 -1.937130275 5.762607334 14.55265378 0.000136297 0.011965708 C1orf116 -2.996699965 1.472284739 14.54606609 0.000136774 0.011965708 STAC 2.817332829 3.090838705 14.51326739 0.000139176 0.012078267 LLGL2 -1.725191048 3.985399734 14.51004624 0.000139414 0.012078267 MYO1C -1.822429219 4.070372105 14.47743242 0.000141849 0.012229834 GP1BA -2.483107312 6.343679866 14.4397017 0.000144719 0.01236859 P2RY10 -2.637185551 2.44009576 14.43807255 0.000144844 0.01236859 CACNA1I -3.759976413 2.25046302 14.39999422 0.000147803 0.012561123 LTBP1 -2.126999095 7.558580778 14.38448941 0.000149025 0.012604954 SULT4A1 -3.393871792 -1.46512394 14.35270599 0.000151562 0.012687521 PLXNB3 -3.224232331 5.120972964 14.34492719 0.000152189 0.012687521 MEX3B 2.183334766 4.641742088 14.34410622 0.000152256 0.012687521 CACNB1 -2.021976739 3.315844531 14.33683729 0.000152845 0.012687521 WDR86 -2.682756882 0.489934543 14.32581152 0.000153742 0.012698173 SCG5 6.553517552 -0.998914598 14.31672182 0.000154486 0.012698173 GNG11 -2.873589968 5.522005307 14.30917066 0.000155107 0.012698173 CHN1 -2.199395302 0.003140502 14.27980149 0.000157546 0.012733452 SRC -2.31686641 6.195624575 14.27558475 0.0001579 0.012733452 NCKAP1 -2.580007834 4.39389155 14.27474783 0.00015797 0.012733452 LIMS1 -1.864911346 7.919510137 14.2697232 0.000158392 0.012733452 RGMB -2.673934658 0.336032613 14.26015091 0.0001592 0.012740986 SAMD14 -2.884489667 4.50490289 14.23341812 0.000161477 0.012813535 GYS2 -2.965789891 0.354048804 14.2326609 0.000161542 0.012813535 MOB3C -2.06743401 5.147321736 14.21376282 0.000163173 0.01288559 BOC -3.298118754 -0.525285259 14.17147613 0.000166881 0.013120396 ADAMTS9 -2.690171021 1.053077941 14.14161007 0.000169552 0.01323577 PF4 -3.023731304 8.18873121 14.13126536 0.000170486 0.01323577 SCML4 -2.515569646 3.115801127 14.12546787 0.000171013 0.01323577 DOK6 -3.275517861 1.927498997 14.11813719 0.00017168 0.01323577 ARID5B -1.675545116 4.514934378 14.11401711 0.000172057 0.01323577 SLC24A3 -2.122172193 4.761899839 14.05288457 0.000177741 0.01361435 PROM1 2.141715134 6.602690052 14.0221022 0.000180674 0.013779896 LGALSL -2.640563998 6.349289917 14.0121267 0.000181635 0.013794244 CCDC64 -2.943186697 2.21593597 13.9945697 0.000183339 0.013864651 LINC00299 -3.267891829 -0.758626593 13.98643654 0.000184134 0.013866002 ZNF521 2.471711075 5.247485077 13.95566182 0.000187173 0.014035622 NXPH4 -3.543512597 -2.055143274 13.91975213 0.000190783 0.014246462 CBX7 -1.735025927 4.565807343 13.86796439 0.000196113 0.014509917 ISLR -3.226672233 0.656920678 13.86518454 0.000196403 0.014509917 ACRBP -2.108101327 4.741795565 13.8618688 0.00019675 0.014509917 LY6G6D -2.935714176 2.072744299 13.83227838 0.000199873 0.014679552 FREM1 3.44171739 5.00302601 13.82300145 0.000200862 0.014691747 LINC00890 4.520508304 -0.101258142 13.79073831 0.000204341 0.014825054 ARHGAP6 -2.312346025 4.921714424 13.78757749 0.000204685 0.014825054 PTGDS -3.05307739 2.270536665 13.78307164 0.000205177 0.014825054 PIGR -4.426911346 -2.208217466 13.7608345 0.00020762 0.014941095 PDE3A -2.457856083 4.756203131 13.71620992 0.000212611 0.015185705 CAPN8 -3.852747406 -2.324731598 13.7152454 0.000212721 0.015185705 LOXL3 -1.732871211 4.991450181 13.7027745 0.000214138 0.015225972

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

GALNT9 -3.507591663 -1.771182336 13.6821323 0.000216505 0.015333167 TSPAN15 -2.668370246 3.148714172 13.66664033 0.000218298 0.015357278 FLT3 1.929921715 7.220848832 13.66433728 0.000218566 0.015357278 ZPBP2 -5.174469301 -2.873210883 13.65102593 0.000220121 0.015405881 PTGIR -2.259395295 4.245916856 13.61937496 0.000223863 0.015606588 FAM87A -4.381558869 -1.871886626 13.59327417 0.000226997 0.015763509 NRGN -2.554493235 7.319847017 13.54392691 0.000233044 0.016120703 KIR3DL2 -3.434854255 -0.166891044 13.53263931 0.00023445 0.016155332 C9orf172 -2.224717862 0.748147197 13.51581461 0.000236561 0.016238122 PCED1B -2.564730271 2.259029042 13.49199634 0.000239583 0.016382532 GPRASP1 -1.786127115 3.844305614 13.45336361 0.000244567 0.016659515 TSPAN32 -1.232900317 6.795338092 13.4288394 0.000247785 0.016786711 NR3C2 -2.444770404 1.630825608 13.42482808 0.000248316 0.016786711 PTGDR -2.830640731 2.381999274 13.3827867 0.000253944 0.016988939 GATA3 -2.336200704 2.073357066 13.3774639 0.000254666 0.016988939 LOC285766 -3.11606236 0.058588962 13.37469409 0.000255042 0.016988939 LURAP1 3.728213664 0.7763505 13.37415972 0.000255115 0.016988939 SBDS -1.312391987 5.902632938 13.32818573 0.000261446 0.017265126 POU6F1 -1.932952549 2.520037133 13.32517186 0.000261867 0.017265126 C15orf26 -3.265845657 1.409482887 13.32304237 0.000262164 0.017265126 GSTA1 -4.764769896 -1.845673559 13.28228461 0.000267926 0.017579676 DEGS2 4.796576878 0.787607113 13.26261218 0.000270752 0.017700047 HOXC4 -2.812936245 -1.544513829 13.24181461 0.000273773 0.017771385 LPAL2 -3.105132423 -0.705685869 13.24138938 0.000273835 0.017771385 MYL9 -2.948835903 6.117547613 13.22909896 0.000275636 0.017774921 DDX11L5 -4.184979933 -2.221255051 13.2274337 0.000275881 0.017774921 JAKMIP1 -3.269100162 0.479790282 13.19120141 0.000281267 0.018056704 TUBA8 -2.179077166 5.129271449 13.16854514 0.000284688 0.018210828 TMEM184A -1.994401583 1.458829783 13.16143821 0.000285769 0.018214741 KIR3DX1 -3.169117517 -0.636493152 13.13778403 0.0002894 0.018346252 SDPR -2.541955198 7.525879009 13.1346226 0.000289889 0.018346252 GAS2L1 -2.007047821 5.281452395 13.12726074 0.00029103 0.018353399 RGS6 -3.022335548 3.108230778 13.09495873 0.000296092 0.01860685 MEX3A 2.637813658 3.365218867 13.07718865 0.000298914 0.018718294 STEAP1B -3.159861593 -1.935410216 13.0662447 0.000300665 0.018730588 CD69 -1.961263193 7.024859204 13.05054773 0.000303196 0.018730588 RADIL -2.348955498 2.143001147 13.04715935 0.000303745 0.018730588 OMD -4.026207153 -1.366064124 13.04342641 0.000304351 0.018730588 LRRIQ3 4.471307091 -0.671590351 13.04338423 0.000304358 0.018730588 ELOVL7 -2.344179179 4.778232375 13.02605664 0.000307187 0.018839729 MMRN1 -2.08593273 7.760509306 13.01255973 0.000309409 0.018878138 KLF12 -1.645183715 5.018998942 13.00941631 0.000309929 0.018878138 LINC01122 2.982176141 2.002378645 12.98437242 0.000314102 0.019018777 ATHL1 -1.774680909 7.068948716 12.97745903 0.000315264 0.019018777 DGCR9 -2.551671644 -0.147109484 12.97066796 0.000316409 0.019018777 RNF165 -2.787528078 -0.657103854 12.97012982 0.0003165 0.019018777 PIK3CD-AS2 3.567869088 0.373377744 12.957161 0.0003187 0.019086714 WFDC1 -1.976775471 3.213532896 12.93901711 0.000321804 0.019208143 THEM5 -2.742142573 -0.839829457 12.92343027 0.000324495 0.019304187 MYOM1 -2.150766587 3.584954002 12.86477399 0.000334825 0.019852584 ESAM -2.475370966 5.241999405 12.83672472 0.000339882 0.020085677

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

RASGRP1 -2.135574312 3.993156438 12.81373382 0.000344084 0.0202669 BTLA -2.548599246 1.685696606 12.80055308 0.000346517 0.020295141 CLDN3 -3.304064353 1.406543158 12.79882018 0.000346838 0.020295141 TTC39A -2.545946191 -0.463129972 12.78964254 0.000348544 0.020328299 PROS1 -2.476698707 5.204515687 12.7770385 0.0003509 0.020399064 HPGDS 2.553712352 3.787634979 12.76451407 0.000353257 0.020469429 HOXB9 -4.38957445 -2.333841198 12.73990774 0.000357935 0.020673373 PRSS50 -3.550840655 1.83135444 12.73297023 0.000359266 0.020683264 CD9 -2.155027254 6.670069565 12.72079769 0.000361611 0.020733577 TPM2 -1.654256114 6.086917571 12.71639947 0.000362463 0.020733577 RNF150 3.452845315 1.348879933 12.68262055 0.00036907 0.021014332 DOCK9 -2.322846537 3.258013297 12.67929972 0.000369726 0.021014332 CTGF -2.146258014 3.367777478 12.66244472 0.000373074 0.021116054 RAB30 -2.185298389 4.047169521 12.6583999 0.000373882 0.021116054 PDK4 -2.512022093 4.39687387 12.63227258 0.000379144 0.021279579 TBXA2R -2.392855194 2.984897406 12.63218319 0.000379162 0.021279579 CPZ -2.965269143 -1.110186688 12.58971316 0.000387876 0.021700367 ZFPM2 -2.490099745 1.685925338 12.57668902 0.000390588 0.02178383 HTR1F 2.340401107 3.766918 12.57017832 0.000391951 0.021791753 DNAH2 5.164879771 1.418198938 12.56310909 0.000393437 0.021806409 ABHD11-AS1 -2.9007599 0.439900523 12.5253605 0.000401465 0.022182519 ISM1 -2.52968534 -0.871320878 12.5183911 0.000402966 0.022196696 COL6A3 -3.109820809 5.579706321 12.48838444 0.00040949 0.022454528 IGSF9B -2.730964107 0.920115774 12.48531822 0.000410163 0.022454528 CCDC65 -2.141265697 0.61579377 12.46419279 0.000414828 0.022566788 CFAP46 4.914079688 0.051498404 12.45966564 0.000415834 0.022566788 HTR2A -2.912900622 1.542069528 12.45889132 0.000416007 0.022566788 LOC101928134 6.977612806 -0.57892848 12.44705809 0.000418651 0.022603706 LOC100505530 -4.516118728 -1.697837058 12.44451818 0.00041922 0.022603706 ZFYVE28 -2.178172553 2.338143598 12.42969851 0.00042256 0.022715152 CYP4F35P -2.108413654 0.745829536 12.42120242 0.000424487 0.0227502 ANGPTL4 -2.773731098 1.29545323 12.41548531 0.000425788 0.022751631 WDR44 -1.442666742 4.988661575 12.40548105 0.000428076 0.022805564 EXOC3L2 -2.548425548 3.546664171 12.39130887 0.000431337 0.022865747 CHADL -2.370026157 1.138036603 12.38408943 0.000433008 0.022865747 HIST1H2AM 4.49542297 -0.343546916 12.38391228 0.000433049 0.022865747 TRAT1 -3.165035083 1.643761854 12.35801191 0.000439098 0.023116763 EFHC2 -1.616639571 4.230749713 12.34322451 0.00044259 0.023131885 KCNH8 -2.652328335 0.998842609 12.34119485 0.000443071 0.023131885 COL3A1 -3.26045941 2.387693618 12.34034268 0.000443274 0.023131885 DNM3OS -2.667099291 -0.353504389 12.33119542 0.000445451 0.02317774 SEC14L5 -3.293148142 3.359851017 12.32263311 0.000447499 0.023216612 TMCC2 -2.26507466 3.913812291 12.31581824 0.000449136 0.023233989 LIPH -3.147185514 0.883076977 12.30199959 0.000452473 0.02333899 SLC13A5 -4.327598024 -2.326603602 12.27555614 0.00045893 0.023496028 HRK -3.047434918 -1.098366076 12.27333714 0.000459476 0.023496028 ITGA10 -1.927032849 0.728790568 12.26621269 0.000461233 0.023496028 WT1 6.29879039 -0.758870041 12.26019949 0.000462722 0.023496028 PPBP -3.38295341 9.95500837 12.26004519 0.00046276 0.023496028 KLRG2 5.174123666 0.123012535 12.25739926 0.000463417 0.023496028 PARVB -1.485079057 6.979542332 12.24680648 0.000466055 0.023529737

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

FHL1 -1.507834902 6.864047878 12.24415195 0.000466719 0.023529737 TNN -3.857556096 -1.447358806 12.21357415 0.000474431 0.023777685 SAPCD2 1.604367458 4.910189729 12.21023744 0.00047528 0.023777685 BEST3 -3.085451183 0.850142788 12.2088492 0.000475634 0.023777685 LOC643733 -2.858982922 0.099650951 12.16734452 0.000486335 0.024244748 KLRB1 -2.817693811 2.284904886 12.15624871 0.000489237 0.024256083 KCNQ4 -2.232124492 2.504468105 12.15608183 0.000489281 0.024256083 HPSE -2.213839262 5.478060032 12.127282 0.000496895 0.024565327 FERMT1 3.625614929 3.290902439 12.09506288 0.000505555 0.024924425 FCRL2 -3.246804401 3.335743812 12.07996492 0.000509666 0.025057855 DNM1 -1.942642297 4.03462219 12.06075106 0.000514945 0.02521551 PATL2 -1.957285478 3.237483187 12.05802873 0.000515698 0.02521551 HS1BP3-IT1 -3.774815898 -2.413804045 12.04862699 0.000518305 0.025273762 MDGA2 7.344551038 -0.077697513 12.0025976 0.000531265 0.025835089 TF -2.811307754 3.921667292 11.98747728 0.000535592 0.025974778 TYMS 1.495504388 6.053023295 11.96873268 0.000541007 0.026166277 EHD3 -2.011175104 5.387586324 11.95334088 0.000545495 0.026312015 CNST -1.493580058 6.641235997 11.92136027 0.000554939 0.026632871 SLC27A2 1.610823324 5.043601867 11.91433812 0.000557035 0.026632871 TCEA3 -2.624035256 0.538531554 11.90830508 0.000558842 0.026632871 PDE5A -2.564403276 5.534764717 11.9015527 0.000560872 0.026632871 RUNDC3A-AS1 -2.554821757 -1.318264007 11.9010885 0.000561012 0.026632871 SPON2 -1.683424667 3.365337394 11.90079328 0.0005611 0.026632871 CMTM5 -2.443091809 5.340235698 11.87034233 0.000570349 0.027000063 CDC14B -1.915069596 4.582608985 11.85764578 0.000574251 0.027112847 RBPMS2 -2.10729076 4.436387036 11.84435549 0.000578364 0.027234988 LRRC32 -2.483624109 3.017734509 11.83630043 0.000580871 0.027281073 GP6 -2.50123115 4.927603689 11.81194892 0.000588518 0.027543946 ARHGEF3 -1.407296331 5.575989516 11.80587203 0.000590442 0.027543946 KCNE4 -3.668439206 -1.069159187 11.79966311 0.000592414 0.027543946 KAZN -1.865994368 4.082067791 11.79783173 0.000592997 0.027543946 CHGB 6.101952003 -1.356834885 11.79410728 0.000594185 0.027543946 PRSS27 -2.064723514 1.432870415 11.78478113 0.000597169 0.027610563 PRKXP1 -2.055543505 3.643995953 11.77928825 0.000598934 0.027620598 LTK -1.671687413 4.514195132 11.75098749 0.00060811 0.027971477 P2RX5 -1.796004015 3.59956898 11.73143931 0.00061453 0.028194153 CEMIP -1.942176528 1.96917044 11.71998306 0.000618325 0.028231276 ETS1 -1.872948056 6.886520394 11.71841948 0.000618845 0.028231276 ILK -1.594940005 7.501740671 11.71080144 0.000621384 0.028231276 PRKCH -1.535481997 5.48577684 11.70643404 0.000622844 0.028231276 TTC39B -1.851271849 3.297068164 11.70522374 0.000623249 0.028231276 SPARC -1.910220919 7.367598257 11.69459095 0.00062682 0.028288743 PTPRF -1.860459963 2.557597296 11.69201848 0.000627688 0.028288743 TGFB2 -3.027796632 -0.559041637 11.68062774 0.000631542 0.028390765 LOC101927746 6.668763744 -0.635432999 11.67386178 0.000633843 0.028422606 LSR -1.83657293 3.052070236 11.66106836 0.000638217 0.028455894 MORC1 -2.926691809 1.132152295 11.65902068 0.00063892 0.028455894 SYTL2 -2.257247344 1.96931304 11.65771362 0.000639369 0.028455894 NKAIN4 -4.66670606 -2.666605967 11.65176492 0.000641417 0.028476021 MAP7 1.860853526 6.034736393 11.60723217 0.000656958 0.029093643 GZMB -2.727768261 2.610301488 11.58040075 0.000666506 0.029443387

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

CCDC85A -3.343282472 -2.038299877 11.57434831 0.000668679 0.02946644 SKA3 1.557512792 4.923859828 11.56794536 0.000670985 0.029495253 PCP2 -1.940826511 1.837451851 11.53413363 0.000683299 0.029904856 TUSC5 -3.627491905 -2.394774055 11.53316709 0.000683654 0.029904856 TREML1 -2.867812095 5.664012687 11.52701126 0.000685922 0.029930685 CARD11 -1.654332915 5.229890188 11.50753308 0.000693147 0.030121483 SP2-AS1 2.759028213 0.987484112 11.50613113 0.00069367 0.030121483 KLRC2 -4.081284745 -0.413373381 11.47988379 0.000703535 0.030455529 PRSS35 -5.124600774 -1.327189746 11.47660965 0.000704776 0.030455529 RAB6B -2.094257152 4.75197259 11.46939787 0.000707516 0.030500092 LINC00861 -3.538191147 2.600195909 11.4640663 0.000709549 0.030514014 PCAT18 4.558926602 1.173946034 11.4526736 0.000713912 0.030627858 KALRN -2.418603831 4.224931955 11.42780395 0.000723532 0.030966108 FNDC1 -3.410824139 -0.306672854 11.40385726 0.000732918 0.03129278 SLC5A4 -3.826766932 -1.828118149 11.38915038 0.000738743 0.031403427 SAMD3 -2.905505372 1.892955558 11.38843323 0.000739028 0.031403427 DOK7 -2.69322458 -1.218244692 11.37259496 0.000745357 0.031577463 EWSAT1 -2.866824927 -1.015948789 11.36699947 0.000747606 0.031577463 PDGFB -2.979193622 3.858748415 11.36287034 0.000749269 0.031577463 PROSER2 -1.678350723 4.822535103 11.36056152 0.000750201 0.031577463 HOXA6 3.117499077 0.939094347 11.34391954 0.000756954 0.031786723 ADGRL3 -3.029746758 -2.211180706 11.3377486 0.000759473 0.031817657 TMPRSS3 -2.836631895 -0.972030143 11.32787602 0.000763522 0.031841945 CYTL1 2.180158356 5.60311365 11.32763368 0.000763621 0.031841945 APCDD1 -2.457926667 0.470910055 11.31716144 0.00076794 0.031947385 SLC37A1 -1.319616468 6.223574746 11.31137601 0.000770337 0.031972553 LINC01529 5.026313047 -0.249265 11.30539903 0.00077282 0.032001219 MFAP3L -2.391568214 4.842403296 11.2925111 0.000778204 0.032080198 PZP -3.295466182 -0.622492018 11.2922268 0.000778323 0.032080198 KCNT1 -2.683917926 -1.40548175 11.28640521 0.000780767 0.0321068 FCRL6 -3.352205307 1.992118151 11.28100173 0.000783043 0.032126361 PEAR1 -2.048567205 5.740101204 11.26679694 0.000789058 0.032298879 SLC38A11 -4.287380606 -1.434749472 11.25750608 0.000793017 0.032386663 WNT11 -2.512197424 2.292760639 11.25094118 0.000795827 0.032410332 IFIT1B -2.800173637 0.801392448 11.24767432 0.000797228 0.032410332 SATB2 -2.182326016 0.762649466 11.23830263 0.000801264 0.032492261 UNC45B -3.359334813 -2.010347123 11.2345518 0.000802885 0.032492261 PCSK6 -3.015609218 4.114666346 11.22692744 0.00080619 0.032552202 PTCRA -2.974450362 3.274363647 11.208604 0.000814189 0.032800992 SOX8 -2.496386857 -1.01439916 11.2020883 0.000817053 0.03284223 RRAS2 -1.890782773 1.92344272 11.19329087 0.000820936 0.032924153 TUNAR -4.175289465 -1.958530658 11.1661154 0.000833049 0.033304076 ASB9 2.202999311 3.37176334 11.16035697 0.000835638 0.033304076 HEXIM1 -1.263768672 6.394317443 11.15953777 0.000836008 0.033304076 KLRC1 -3.575125191 -0.222763185 11.1511675 0.000839788 0.033322524 CDH9 3.466305644 1.459770401 11.15024701 0.000840205 0.033322524 MIR4701 -2.681997524 -1.550487139 11.13405382 0.000847572 0.033501565 ZBED2 -3.52124728 -1.914398506 11.12961668 0.000849601 0.033501565 CPA3 2.510605324 7.264753454 11.12706426 0.000850771 0.033501565 KIT 2.277300244 7.232048422 11.11670844 0.000855535 0.033501565 CTLA4 -3.829605813 1.056394103 11.11628489 0.00085573 0.033501565

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

MFGE8 1.426119202 5.229735116 11.11174811 0.000857826 0.033501565 NTPCR 1.722174325 4.258313614 11.11167604 0.000857859 0.033501565 DPY19L2P3 4.142081459 -0.679099837 11.1040474 0.000861395 0.033566202 COL24A1 -1.70511405 5.475055158 11.09433427 0.000865919 0.033603967 RGS10 -1.549200429 5.939156335 11.09182522 0.000867091 0.033603967 DISC1FP1 6.200500122 -1.125447812 11.08985428 0.000868013 0.033603967 SAMD13 2.597551699 2.483968471 11.08047906 0.000872413 0.033701185 FHOD1 -1.318711097 6.727910989 11.05317802 0.000885353 0.034127206 LRRC71 -3.096795907 -1.10157072 11.04784253 0.000887905 0.034129424 BTBD18 6.027751563 -1.157512633 11.04506616 0.000889235 0.034129424 DSCC1 1.730975477 4.52791672 11.02674676 0.000898066 0.034394392 TNFRSF18 -2.128422682 1.477884004 11.01174685 0.000905363 0.034547183 KLRC3 -3.094529924 -0.186282426 11.01059188 0.000905927 0.034547183 CLU -1.945366072 7.35689418 10.9933571 0.00091439 0.034795573 PTPRS -1.634152734 4.165598425 10.9583628 0.000931821 0.035383428 HIST1H4E 6.396921363 -0.924657834 10.93119107 0.000945587 0.035765678 C6orf25 -2.226318822 6.628957124 10.9305861 0.000945896 0.035765678 CCR6 -2.827290232 0.718400112 10.92353342 0.000949503 0.035796655 FAM86C2P 2.78829889 1.105944875 10.92114866 0.000950726 0.035796655 COL4A4 -2.449004557 1.488126451 10.91668899 0.000953018 0.03580739 RGS18 -1.932854964 6.889690908 10.89821524 0.00096257 0.036062634 TNNC2 -2.59114395 0.411354083 10.8957481 0.000963853 0.036062634 CNNM1 2.585825622 2.227883438 10.87521186 0.000974599 0.03638842 LINC00634 6.106970477 -1.197763173 10.85442485 0.0009856 0.036620177 SH3BGRL2 -2.229171826 5.446083027 10.85410034 0.000985772 0.036620177 FAM65C -1.661182097 6.600855224 10.84705766 0.000989529 0.036620177 CTDSPL -1.392927523 6.323985128 10.84460825 0.000990838 0.036620177 BCL11B -3.579718659 3.314244098 10.84418392 0.000991065 0.036620177 PIK3C2B -1.648586121 4.499425239 10.8168117 0.001005826 0.037088776 BTN3A1 -1.305183187 5.965946124 10.79893695 0.001015584 0.037371396 CD226 -2.83513785 4.935700244 10.78340186 0.001024143 0.037538656 SLC5A11 -2.73610076 -1.729844276 10.78305276 0.001024336 0.037538656 ARMC3 -3.36609925 -0.164730989 10.76778757 0.001032819 0.037753703 STRIP2 -1.649481123 4.091512829 10.76489386 0.001034435 0.037753703 MIR3960 -2.970738318 -1.385386865 10.75371464 0.001040702 0.037904923 STAT4 -1.675585839 3.697150349 10.74059496 0.001048106 0.038039528 TMEM97 1.708292562 4.736529971 10.73961636 0.001048661 0.038039528 CA13 -1.89418834 2.255743814 10.71737495 0.001061341 0.03842142 PREX2 2.734229791 2.741144062 10.7020962 0.001070142 0.038596574 RASGRP3 -1.425798575 4.931098516 10.7014689 0.001070505 0.038596574 FAAHP1 -2.830168821 -1.038163008 10.69318256 0.001075311 0.03869167 TMEM40 -2.939664566 3.924663423 10.68597917 0.001079506 0.038752939 LINC00298 -4.25592763 -2.503120937 10.68281099 0.001081356 0.038752939 SIAE -1.498071313 4.663552664 10.67377369 0.001086652 0.038864687 CCL5 -2.59587304 5.645519399 10.66550006 0.001091523 0.03891429 GATA2 2.037574831 6.697706574 10.66401551 0.0010924 0.03891429 SELP -2.186688453 6.341184758 10.64440311 0.001104045 0.039250782 SEPT4 -2.414532943 2.197531525 10.63935467 0.001107063 0.039257915 SOX13 -2.683891681 0.536819509 10.63516868 0.001109572 0.039257915 NKX2-3 3.77544905 0.860842961 10.63099294 0.00111208 0.039257915 NUAK1 -2.855642791 0.679927692 10.62938958 0.001113044 0.039257915

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

IFITM5 -3.077369745 -2.034629173 10.62327382 0.001116732 0.039310275 C1orf186 2.105978533 3.947515938 10.60654513 0.00112688 0.03952161 FRMD4B -1.610938859 5.991952878 10.60607967 0.001127164 0.03952161 PPP1R16B -1.441084813 5.281778119 10.59576743 0.001133468 0.039664727 KLRD1 -3.215792963 1.767412868 10.58721505 0.001138724 0.039737933 ITGA6 -1.568440828 6.906889644 10.5850961 0.00114003 0.039737933 NPR3 1.844832624 7.235017849 10.58151504 0.00114224 0.039737933 LHX6 3.116137731 0.469303836 10.57032813 0.001149173 0.039901353 LY6G6F -2.654302985 5.002331477 10.54508672 0.001164974 0.040371424 COL6A1 -2.023287661 3.11967583 10.53405198 0.00117195 0.040494025 RAB3B -2.764396592 -0.671662736 10.53075312 0.001174044 0.040494025 CAMK2N1 -3.388644216 -1.129635437 10.52874772 0.001175318 0.040494025 SLFN14 -2.484843437 2.371929408 10.52348759 0.001178668 0.040531202 C15orf59 -3.561964961 -1.579251839 10.50862243 0.001188188 0.040779984 TRAF1 -1.906717176 4.361411739 10.50182066 0.00119257 0.04085181 CACNA2D1 -3.235851808 -1.250843374 10.4890683 0.001200829 0.041055933 MCF2L -2.299660941 3.534318416 10.48001657 0.001206727 0.041178685 LOC101928150 -2.394233315 0.838484991 10.46715886 0.001215155 0.041284299 CD5 -2.939281508 3.267481186 10.46666976 0.001215476 0.041284299 GRB14 -2.838619262 -0.06616543 10.46471763 0.001216761 0.041284299 PMEPA1 -1.817056978 1.950920924 10.43868645 0.00123403 0.041790765 HOXB-AS3 3.499564344 0.370756483 10.42158266 0.001245511 0.042099691 TMPRSS13 -1.895050008 0.551447187 10.41252209 0.001251637 0.042132561 TCF7 -3.114028228 4.213433051 10.4121243 0.001251907 0.042132561 GPM6A -2.462907379 0.796881822 10.4093202 0.001253809 0.042132561 ZBTB32 -2.092110931 0.84206424 10.40403615 0.001257402 0.042132561 LINC01599 -2.776243019 -0.878976493 10.40068652 0.001259685 0.042132561 F13A1 -2.462908271 8.067490033 10.39927477 0.001260648 0.042132561 ICOS -3.659725208 1.573591416 10.38624228 0.001269577 0.042351678 LEFTY1 -3.045235837 1.035566728 10.38126106 0.001273007 0.042386864 FRMPD3 -3.716335885 -0.953988558 10.36075675 0.001287224 0.042780431 FAM129C -2.318783946 5.667050286 10.34678351 0.001297005 0.042975856 TIGD3 2.450303848 1.202230253 10.34193859 0.001300414 0.042975856 TNNI3 -3.118751681 0.363952719 10.34092947 0.001301125 0.042975856 CDO1 -2.986600508 -0.791346066 10.33580587 0.001304741 0.042975856 EMID1 1.996738679 6.27344763 10.33523581 0.001305144 0.042975856 ENTPD8 -2.283921403 0.467728499 10.31319885 0.001320821 0.043358839 KIAA1462 -2.075621 2.860247839 10.31206331 0.001321634 0.043358839 CDC42BPB -1.666817789 5.419308689 10.30008823 0.001330238 0.043561039 LOC100652768 -1.737736332 1.775345921 10.28439538 0.0013416 0.04385262 ITIH5 -2.875287143 1.214704272 10.27643889 0.001347398 0.043890912 PKHD1L1 -2.816364804 5.310084767 10.2729976 0.001349913 0.043890912 HIST1H2BO 6.128520264 -0.732397487 10.27267496 0.001350149 0.043890912 SRMS -2.498552487 -1.201514412 10.2514759 0.001365753 0.044317439 EFNB2 -2.122824189 3.768508439 10.24416616 0.001371176 0.044412649 RASGRF2 -2.775722176 1.856608433 10.23316908 0.001379375 0.044517609 CACNA1H -2.553527049 0.091933779 10.23312875 0.001379405 0.044517609 CABP5 -3.373441353 0.760795875 10.22290504 0.001387072 0.044651821 LINC00900 6.128908487 -1.294799972 10.22091787 0.001388567 0.044651821 TMEM63B -1.330853014 4.178204311 10.21556112 0.001392606 0.044701155 GUSBP2 4.071528265 0.012463756 10.20721031 0.001398926 0.04476547

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

CD28 -3.384373663 3.137508232 10.20628755 0.001399626 0.04476547 ZAP70 -2.442146242 5.396093555 10.20154754 0.001403228 0.044800391 CPNE5 -2.159164698 3.506551304 10.19781111 0.001406075 0.044811093 FXYD7 -2.287417419 -0.630332835 10.19160568 0.001410814 0.044881996 SLC25A29 1.587959797 6.76999056 10.185222 0.001415707 0.044893134 ACOT7 1.686767703 5.063030336 10.18458601 0.001416195 0.044893134 DUSP5 -1.728940036 4.811936823 10.16906579 0.001428166 0.045172886 MYEOV -2.591789981 0.8956474 10.16584682 0.001430662 0.045172886 C20orf195 -2.251106512 -0.869055009 10.16333351 0.001432614 0.045172886 RUNX3 -1.244844762 6.753106466 10.15908657 0.001435917 0.045197212 FBXO32 -1.696034624 2.802566033 10.14846222 0.001444217 0.045378406 CD83 -1.75398988 5.553061363 10.12634499 0.00146165 0.045829194 GP5 -2.788310262 5.288008001 10.12376216 0.001463699 0.045829194 C3orf52 -1.996992592 2.122878356 10.11378124 0.001471647 0.045997351 PLEKHA1 -1.735355833 3.52829791 10.09672441 0.001485331 0.046343887 PTCH1 -2.52453659 1.737191745 10.08732187 0.001492929 0.046499666 HES1 -2.275793742 2.477464379 10.08023954 0.001498678 0.046597413 SLC17A3 -3.220158294 -2.160191869 10.07103478 0.001506184 0.046749337 CRIP2 -1.959987217 1.906929467 10.05984047 0.001515363 0.04695259 TTLL10 3.467315736 -0.459553267 10.05523027 0.00151916 0.046988654 KCNJ9 -3.779328723 -2.559067108 10.04458873 0.001527961 0.047179104 C11orf96 -2.260417846 2.640129915 10.02599478 0.001543463 0.047575446 SGCB -1.82220547 1.577272502 10.00884649 0.001557901 0.047937678 ELOVL4 -3.179156771 -1.857378544 9.992846997 0.001571495 0.048272742 IGF2BP3 -1.756011147 3.323800693 9.977098613 0.001584992 0.048554039 CD2 -2.565720877 2.824429434 9.974719646 0.001587042 0.048554039 PRR5L -1.510966825 3.719537322 9.972664798 0.001588814 0.048554039 FBLN7 -3.713173934 -1.546575571 9.958525352 0.001601062 0.048844721 ZC3H12D -1.924274334 3.705706888 9.9443337 0.001613453 0.049138717 TCEAL7 5.960665294 -1.362885464 9.933912095 0.001622613 0.049318833 ZNF229 2.146059828 2.685754551 9.931327001 0.001624893 0.049318833 GZMM -2.707600899 1.926255682 9.925800519 0.00162978 0.049374831 LOC101928100 -2.821904821 0.100102116 9.922988285 0.001632272 0.049374831 MAP1B -2.462014695 -0.224483864 9.917341382 0.001637287 0.049402221 PVALB -2.708611881 -0.438721626 9.915739033 0.001638713 0.049402221 SP7 -2.489908309 -0.140291749 9.911646818 0.001642361 0.049428694 MAOB -2.883236174 2.904169845 9.90115335 0.001651752 0.049627646 KCNK6 -1.687434576 4.017163806 9.895779902 0.001656582 0.049689116 UGT8 -3.153532174 -2.123959481 9.889942758 0.001661845 0.049763347 EGF -2.651841996 4.152225023 9.88219213 0.00166886 0.049820648 NLRP1 -1.495602083 6.557431714 9.881660723 0.001669342 0.049820648

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

Bone Marrow-Derived CD34+ cells from 'Sle.Female Patients: Severe SLE vs Moderate SLE' (|FC|1.5, FDR<0.05) Gene name logFC logCPM LR PValue FDR ADAMTS2 5.026313257 3.570168572 51.90066387 5.84E-13 9.93E-09 NPY -9.316623371 0.454734774 44.44186265 2.62E-11 1.58E-07 RAG1 -5.585416321 5.512402042 44.14510239 3.05E-11 1.58E-07 LINC01013 -9.501965434 2.604213947 43.75772378 3.72E-11 1.58E-07 VPREB1 -7.403749811 5.943676512 41.68129168 1.07E-10 3.66E-07 LCN6 -8.591911849 4.115367162 40.29016447 2.19E-10 6.21E-07 VPREB3 -7.420790519 5.108441557 35.67700888 2.33E-09 5.40E-06 ARPP21 -6.575104232 3.322068934 35.29526324 2.83E-09 5.40E-06 RAG2 -7.623186986 2.75739268 35.27810697 2.86E-09 5.40E-06 DNTT -5.460170218 8.347392947 34.83254201 3.59E-09 6.11E-06 LCN10 -6.373925259 4.567717998 34.28126938 4.77E-09 7.38E-06 AIRE -6.65220314 2.330601798 33.30245864 7.89E-09 1.12E-05 EBF1 -5.180810494 4.344037746 33.02067889 9.12E-09 1.19E-05 PAX5 -4.248392353 4.202117324 31.71276587 1.79E-08 2.17E-05 LOC100128593 -7.493106875 2.102379982 31.31074686 2.20E-08 2.49E-05 CD79B -4.841223859 7.293167324 30.39991725 3.52E-08 3.74E-05 DTX1 -5.541884412 3.232966873 29.46199003 5.70E-08 5.71E-05 CXCL2 3.98491459 5.369042778 29.3217851 6.13E-08 5.79E-05 TCL1B -8.563869327 -0.236823763 28.85125939 7.82E-08 7.00E-05 CAPSL -7.017491083 -1.538051924 27.41457532 1.64E-07 0.000139651 HMHB1 -7.956042741 1.043008673 27.30718376 1.74E-07 0.000140596 MIR5195 -6.010525348 0.65479526 26.98474826 2.05E-07 0.000158564 LY6H -6.652526471 0.698001144 26.55927512 2.56E-07 0.000189025 BACH2 -2.9229643 3.996286419 26.2256104 3.04E-07 0.000212406 LRFN2 -6.239848161 0.729091814 26.17298439 3.12E-07 0.000212406 MIR6722 -7.464031452 0.590843074 25.93066967 3.54E-07 0.000231547 ZAP70 -2.70070197 4.80179776 25.31538987 4.87E-07 0.000306708 CD19 -3.808291627 3.625366728 25.18299219 5.21E-07 0.000316769 CCR7 -3.577272744 2.336060838 24.81761033 6.30E-07 0.000369661 BLACE -6.062133309 0.710581295 24.71164796 6.66E-07 0.000377534 LOC101927740 -5.476663024 0.662557367 24.17625517 8.79E-07 0.000482396 CD22 -3.194185839 4.549833207 24.0034846 9.62E-07 0.000511189 IL7R -3.25722315 4.507766057 23.36762591 1.34E-06 0.000689779 APOD 4.88139828 0.669100432 22.88261841 1.72E-06 0.00083343 NR4A1 2.276562712 5.22850229 22.87600012 1.73E-06 0.00083343 PRKG1 3.347488062 3.625055429 22.75140586 1.84E-06 0.00083343 TCL6 -5.379129698 -0.242647572 22.74020857 1.85E-06 0.00083343 NPTX1 -6.255322957 -2.07751445 22.73266913 1.86E-06 0.00083343 ANTXRLP1 -5.013844707 -0.214604153 22.293402 2.34E-06 0.0010207 CXCL8 4.283004817 7.827192256 22.19224791 2.47E-06 0.001049016 LINC01507 -6.365667558 -0.940575063 22.08189782 2.61E-06 0.001083982 SPARCL1 4.175123761 2.870457258 21.18015019 4.18E-06 0.001684204 HIF3A 4.355299774 0.642452005 21.14536792 4.26E-06 0.001684204 CCL20 6.16123804 0.756065921 21.02504609 4.53E-06 0.001752591 GPR176 -4.370415394 2.01175119 20.55768886 5.79E-06 0.002182442 MMP19 4.723268529 3.115577675 20.51984715 5.90E-06 0.002182442 DBH-AS1 -4.379341917 2.086863056 20.34280148 6.47E-06 0.002343036

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

GYLTL1B -4.127761808 1.73647641 20.0689962 7.47E-06 0.002647261 CXCL3 3.171997035 3.707939717 19.98871169 7.79E-06 0.002704426 CD79A -3.098876677 5.672581412 19.3292086 1.10E-05 0.00374278 PTGS2 3.626584986 6.031099333 18.84870118 1.42E-05 0.004719966 IRX1 -4.094286475 1.371264324 18.69133013 1.54E-05 0.005027394 LOC100996286 -5.104344905 -0.322391744 18.54051221 1.66E-05 0.0053386 LYVE1 3.997840815 3.019491195 18.49135703 1.71E-05 0.005376627 AKAP12 -3.174096435 4.950379067 18.31044881 1.88E-05 0.005804616 TCL1A -4.013445362 1.83866703 18.0103659 2.20E-05 0.006673942 VWF 2.271789963 6.379588941 17.89244902 2.34E-05 0.006975904 COL5A1 -2.551239087 5.679705741 17.59766255 2.73E-05 0.008004661 FIGN 4.274850755 1.696628132 17.51019884 2.86E-05 0.008239396 MYOC 7.179896776 -0.840881192 17.3929864 3.04E-05 0.00861736 C7 3.115313226 3.532667618 17.33132037 3.14E-05 0.008755623 CDH6 3.257544748 2.29014241 17.25554158 3.27E-05 0.008964884 RGS1 2.64764779 6.222315591 17.21170276 3.34E-05 0.009028527 CSF1 2.513720897 6.240009014 16.94553788 3.85E-05 0.010193274 OPALIN -4.262562549 -0.882365238 16.91883938 3.90E-05 0.010193274 AREG 3.327921683 7.851176889 16.8929453 3.95E-05 0.010193274 HHIP -4.689973231 2.322682061 16.53415439 4.78E-05 0.012131534 CD248 -3.259251083 1.460769028 16.39236188 5.15E-05 0.012788328 CCL3L1 5.098079813 0.661147726 16.37843702 5.19E-05 0.012788328 LTB -2.953312145 5.366666553 16.23400193 5.60E-05 0.013472815 CD163 3.636266683 7.267011747 16.22548843 5.62E-05 0.013472815 RNASE1 3.765660122 4.539078508 15.9798036 6.40E-05 0.01512605 RASAL1 -3.643134285 -1.225235618 15.90304476 6.67E-05 0.015536257 LINC00426 -2.971531286 3.301851746 15.78044687 7.11E-05 0.016043256 MSR1 4.941286459 4.037725332 15.75088852 7.23E-05 0.016043256 CH25H 6.243505191 -1.575816309 15.74196688 7.26E-05 0.016043256 EFEMP1 3.997048934 0.139944866 15.73003019 7.31E-05 0.016043256 BLNK -2.408162722 4.710237658 15.716934 7.36E-05 0.016043256 HHIP-AS1 -3.642630752 2.068845855 15.61935826 7.75E-05 0.016678864 XPNPEP2 -3.48213864 0.99463193 15.5111499 8.20E-05 0.017440533 FCMR -2.418388295 4.183238749 15.39126479 8.74E-05 0.018353262 VSIG4 3.533537909 4.293216685 15.2277487 9.53E-05 0.019768624 C6orf25 2.508746227 6.132248462 15.16436401 9.85E-05 0.020197131 PROS1 2.49303295 4.656662868 15.01269992 0.00010679 0.021626265 GSTM3 2.755777228 5.094459751 14.96222247 0.000109685 0.021951242 MAFB 3.001475674 6.401029053 14.91033947 0.000112743 0.02225056 SPP1 7.219397638 6.321889261 14.88233487 0.00011443 0.02225056 DUSP26 -4.54726338 2.401966926 14.87123499 0.000115105 0.02225056 ADH1B 5.524398028 0.170291264 14.67891515 0.000127464 0.02426675 PER1 2.164365318 8.184029878 14.6653041 0.000128388 0.02426675 CDKN1A 2.196614487 5.427290615 14.46582758 0.000142725 0.026680247 GH1 -4.354274225 -0.780675347 14.26629815 0.000158681 0.029340414 KLF9 1.809329036 6.050077821 14.18230694 0.000165923 0.03033451 MAFF 1.700165651 4.666234308 14.16312611 0.000167624 0.03033451 POU4F1 -4.03479518 -0.399737252 14.05234854 0.000177792 0.031529828 LRRC26 -2.864065815 0.083063728 14.05082603 0.000177936 0.031529828 TRPC6 2.305161426 3.50736632 13.93612373 0.000189129 0.032847467 RAB6B 2.234636641 4.399173573 13.93508091 0.000189234 0.032847467

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

EREG 2.335990971 7.821325036 13.91538005 0.000191227 0.032858257 ADGRF1 -3.704516636 -1.144096696 13.8589428 0.000197057 0.033521321 THBS1 3.316894516 8.732064263 13.81412262 0.000201814 0.033990596 SERPINA5 6.110232726 -1.645776553 13.75350496 0.000208432 0.034761068 LINC00114 -5.513907075 0.366228355 13.6856776 0.000216096 0.035689454 IL1R2 7.250751431 7.70696716 13.63172596 0.000222395 0.036110282 RYR2 3.293247117 1.506012232 13.62755566 0.00022289 0.036110282 RNF152 -3.139706743 -0.643934517 13.55482182 0.000231695 0.037182744 CDH1 2.70160875 5.098481011 13.50790038 0.000237561 0.037767789 CMTM8 -2.868348177 2.303293295 13.40439139 0.000251036 0.039540478 HCAR3 3.594880273 2.736013687 13.28050243 0.000268181 0.041853399 CCL4L2 4.32811 0.911937742 13.21506065 0.000277709 0.042940945 CYGB -2.853896337 3.477248822 13.19625388 0.000280509 0.042940945 CREB3L1 -3.800388868 -0.581897104 13.18152818 0.000282722 0.042940945 G0S2 3.081334055 5.134221487 13.14266232 0.000288647 0.043452932 FXYD2 -4.206269994 -1.711739769 13.11022694 0.000293688 0.043823934 ALPL 4.482510959 4.249282055 12.97930171 0.000314953 0.046408618 ADAMTS1 2.808023661 1.967455841 12.96667368 0.000317085 0.046408618 DDR1 -2.140339571 3.531342677 12.95426224 0.000319194 0.046408618 VSIG1 -4.825857392 -0.788041622 12.81217585 0.000344371 0.049346778 MYL9 2.743238352 5.330378891 12.80765449 0.000345204 0.049346778

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

Gene.stable.ID.version Gene.stable.ID Gene.name Gene.type 1 ENSMUSG00000000157.16 ENSMUSG00000000157 Itgb2l protein_coding 2 ENSMUSG00000000204.16 ENSMUSG00000000204 Slfn4 protein_coding 3 ENSMUSG00000000276.11 ENSMUSG00000000276 Dgke protein_coding 4 ENSMUSG00000000690.5 ENSMUSG00000000690 Hoxb6 protein_coding 5 ENSMUSG00000000731.15 ENSMUSG00000000731 Aire protein_coding 6 ENSMUSG00000001025.8 ENSMUSG00000001025 S100a6 protein_coding 7 ENSMUSG00000001095.5 ENSMUSG00000001095 Slc13a2 protein_coding 8 ENSMUSG00000001435.15 ENSMUSG00000001435 Col18a1 protein_coding 9 ENSMUSG00000001482.15 ENSMUSG00000001482 Def8 protein_coding 10 ENSMUSG00000001768.16 ENSMUSG00000001768 Rin2 protein_coding 11 ENSMUSG00000001930.17 ENSMUSG00000001930 Vwf protein_coding 12 ENSMUSG00000001946.14 ENSMUSG00000001946 Esam protein_coding 13 ENSMUSG00000002808.7 ENSMUSG00000002808 Epdr1 protein_coding 14 ENSMUSG00000002985.16 ENSMUSG00000002985 Apoe protein_coding 15 ENSMUSG00000003134.10 ENSMUSG00000003134 Tbc1d8 protein_coding 16 ENSMUSG00000003153.10 ENSMUSG00000003153 Slc2a3 protein_coding 17 ENSMUSG00000003283.14 ENSMUSG00000003283 Hck protein_coding 18 ENSMUSG00000003484.4 ENSMUSG00000003484 Cyp4f18 protein_coding 19 ENSMUSG00000004044.9 ENSMUSG00000004044 Cavin1 protein_coding 20 ENSMUSG00000004668.14 ENSMUSG00000004668 Abca13 protein_coding 21 ENSMUSG00000004730.15 ENSMUSG00000004730 Adgre1 protein_coding 22 ENSMUSG00000004864.13 ENSMUSG00000004864 Mapk13 protein_coding 23 ENSMUSG00000005125.13 ENSMUSG00000005125 Ndrg1 protein_coding 24 ENSMUSG00000005237.14 ENSMUSG00000005237 Dnah2 protein_coding 25 ENSMUSG00000005611.15 ENSMUSG00000005611 Mrvi1 protein_coding 26 ENSMUSG00000005686.17 ENSMUSG00000005686 Ampd3 protein_coding 27 ENSMUSG00000005800.3 ENSMUSG00000005800 Mmp8 protein_coding 28 ENSMUSG00000005803.14 ENSMUSG00000005803 Sqor protein_coding 29 ENSMUSG00000006143.12 ENSMUSG00000006143 Upk3bl protein_coding 30 ENSMUSG00000006205.13 ENSMUSG00000006205 Htra1 protein_coding 31 ENSMUSG00000006386.15 ENSMUSG00000006386 Tek protein_coding 32 ENSMUSG00000008153.11 ENSMUSG00000008153 Clstn3 protein_coding 33 ENSMUSG00000008540.11 ENSMUSG00000008540 Mgst1 protein_coding 34 ENSMUSG00000009292.18 ENSMUSG00000009292 Trpm2 protein_coding 35 ENSMUSG00000009378.3 ENSMUSG00000009378 Slc16a12 protein_coding 36 ENSMUSG00000009418.15 ENSMUSG00000009418 Nav1 protein_coding 37 ENSMUSG00000009628.14 ENSMUSG00000009628 Tex15 protein_coding 38 ENSMUSG00000010461.15 ENSMUSG00000010461 Eya4 protein_coding 39 ENSMUSG00000011751.16 ENSMUSG00000011751 Sptbn4 protein_coding 40 ENSMUSG00000014361.5 ENSMUSG00000014361 Mertk protein_coding 41 ENSMUSG00000015053.14 ENSMUSG00000015053 Gata2 protein_coding 42 ENSMUSG00000015094.16 ENSMUSG00000015094 Npdc1 protein_coding 43 ENSMUSG00000015143.15 ENSMUSG00000015143 Actn1 protein_coding 44 ENSMUSG00000015854.7 ENSMUSG00000015854 Cd5l protein_coding 45 ENSMUSG00000015932.8 ENSMUSG00000015932 Dstn protein_coding 46 ENSMUSG00000015947.10 ENSMUSG00000015947 Fcgr1 protein_coding 47 ENSMUSG00000015950.13 ENSMUSG00000015950 Ncf1 protein_coding

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

48 ENSMUSG00000016024.9 ENSMUSG00000016024 Lbp protein_coding 49 ENSMUSG00000016756.17 ENSMUSG00000016756 Cmah protein_coding 50 ENSMUSG00000017667.9 ENSMUSG00000017667 Zfp334 protein_coding 51 ENSMUSG00000017737.2 ENSMUSG00000017737 Mmp9 protein_coding 52 ENSMUSG00000017754.13 ENSMUSG00000017754 Pltp protein_coding 53 ENSMUSG00000019832.5 ENSMUSG00000019832 Rab32 protein_coding 54 ENSMUSG00000019894.14 ENSMUSG00000019894 Slc6a15 protein_coding 55 ENSMUSG00000019935.16 ENSMUSG00000019935 Slc17a8 protein_coding 56 ENSMUSG00000020019.4 ENSMUSG00000020019 Ntn4 protein_coding 57 ENSMUSG00000020027.18 ENSMUSG00000020027 Socs2 protein_coding 58 ENSMUSG00000020135.13 ENSMUSG00000020135 Apc2 protein_coding 59 ENSMUSG00000020176.17 ENSMUSG00000020176 Grb10 protein_coding 60 ENSMUSG00000020227.10 ENSMUSG00000020227 Irak3 protein_coding 61 ENSMUSG00000020310.9 ENSMUSG00000020310 Madcam1 protein_coding 62 ENSMUSG00000020407.13 ENSMUSG00000020407 Upp1 protein_coding 63 ENSMUSG00000020609.14 ENSMUSG00000020609 Apob protein_coding 64 ENSMUSG00000020681.14 ENSMUSG00000020681 Ace protein_coding 65 ENSMUSG00000020689.4 ENSMUSG00000020689 Itgb3 protein_coding 66 ENSMUSG00000020709.15 ENSMUSG00000020709 Adap2 protein_coding 67 ENSMUSG00000020773.11 ENSMUSG00000020773 Trim47 protein_coding 68 ENSMUSG00000020774.9 ENSMUSG00000020774 Aspa protein_coding 69 ENSMUSG00000020787.14 ENSMUSG00000020787 P2rx1 protein_coding 70 ENSMUSG00000020846.6 ENSMUSG00000020846 Rflnb protein_coding 71 ENSMUSG00000020865.16 ENSMUSG00000020865 Abcc3 protein_coding 72 ENSMUSG00000020902.12 ENSMUSG00000020902 Ntn1 protein_coding 73 ENSMUSG00000020961.15 ENSMUSG00000020961 Ston2 protein_coding 74 ENSMUSG00000021069.17 ENSMUSG00000021069 Pygl protein_coding 75 ENSMUSG00000021125.6 ENSMUSG00000021125 Arg2 protein_coding 76 ENSMUSG00000021268.17 ENSMUSG00000021268 Meg3 lincRNA 77 ENSMUSG00000021280.9 ENSMUSG00000021280 Exoc3l4 protein_coding 78 ENSMUSG00000021281.15 ENSMUSG00000021281 Tnfaip2 protein_coding 79 ENSMUSG00000021559.14 ENSMUSG00000021559 Dapk1 protein_coding 80 ENSMUSG00000021596.16 ENSMUSG00000021596 Mctp1 protein_coding 81 ENSMUSG00000021614.16 ENSMUSG00000021614 Vcan protein_coding 82 ENSMUSG00000021796.15 ENSMUSG00000021796 Bmpr1a protein_coding 83 ENSMUSG00000022015.8 ENSMUSG00000022015 Tnfsf11 protein_coding 84 ENSMUSG00000022026.7 ENSMUSG00000022026 Olfm4 protein_coding 85 ENSMUSG00000022037.15 ENSMUSG00000022037 Clu protein_coding 86 ENSMUSG00000022103.10 ENSMUSG00000022103 Gfra2 protein_coding 87 ENSMUSG00000022225.7 ENSMUSG00000022225 Cma1 protein_coding 88 ENSMUSG00000022261.6 ENSMUSG00000022261 Sdc2 protein_coding 89 ENSMUSG00000022367.7 ENSMUSG00000022367 Has2 protein_coding 90 ENSMUSG00000022371.16 ENSMUSG00000022371 Col14a1 protein_coding 91 ENSMUSG00000022468.12 ENSMUSG00000022468 Endou protein_coding 92 ENSMUSG00000022508.5 ENSMUSG00000022508 Bcl6 protein_coding 93 ENSMUSG00000022512.3 ENSMUSG00000022512 Cldn1 protein_coding 94 ENSMUSG00000022623.16 ENSMUSG00000022623 Shank3 protein_coding 95 ENSMUSG00000022788.16 ENSMUSG00000022788 Fgd4 protein_coding 96 ENSMUSG00000022818.13 ENSMUSG00000022818 Cyp2ab1 protein_coding 97 ENSMUSG00000022824.12 ENSMUSG00000022824 Muc13 protein_coding 98 ENSMUSG00000022885.16 ENSMUSG00000022885 St6gal1 protein_coding

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

99 ENSMUSG00000022892.11 ENSMUSG00000022892 App protein_coding 100 ENSMUSG00000023022.14 ENSMUSG00000023022 Lima1 protein_coding 101 ENSMUSG00000023092.16 ENSMUSG00000023092 Fhl1 protein_coding 102 ENSMUSG00000023191.9 ENSMUSG00000023191 P3h3 protein_coding 103 ENSMUSG00000023349.14 ENSMUSG00000023349 Clec4n protein_coding 104 ENSMUSG00000023473.12 ENSMUSG00000023473 Celsr3 protein_coding 105 ENSMUSG00000023886.10 ENSMUSG00000023886 Smoc2 protein_coding 106 ENSMUSG00000023913.17 ENSMUSG00000023913 Pla2g7 protein_coding 107 ENSMUSG00000023960.13 ENSMUSG00000023960 Enpp5 protein_coding 108 ENSMUSG00000024011.16 ENSMUSG00000024011 Pi16 protein_coding 109 ENSMUSG00000024053.11 ENSMUSG00000024053 Emilin2 protein_coding 110 ENSMUSG00000024164.15 ENSMUSG00000024164 C3 protein_coding 111 ENSMUSG00000024500.18 ENSMUSG00000024500 Ppp2r2b protein_coding 112 ENSMUSG00000024621.15 ENSMUSG00000024621 Csf1r protein_coding 113 ENSMUSG00000024659.14 ENSMUSG00000024659 Anxa1 protein_coding 114 ENSMUSG00000024679.10 ENSMUSG00000024679 Ms4a6d protein_coding 115 ENSMUSG00000024730.7 ENSMUSG00000024730 Ms4a8a protein_coding 116 ENSMUSG00000024774.15 ENSMUSG00000024774 Ankrd22 protein_coding 117 ENSMUSG00000025014.12 ENSMUSG00000025014 Dntt protein_coding 118 ENSMUSG00000025044.16 ENSMUSG00000025044 Msr1 protein_coding 119 ENSMUSG00000025089.15 ENSMUSG00000025089 Gfra1 protein_coding 120 ENSMUSG00000025094.7 ENSMUSG00000025094 Slc18a2 protein_coding 121 ENSMUSG00000025161.16 ENSMUSG00000025161 Slc16a3 protein_coding 122 ENSMUSG00000025170.13 ENSMUSG00000025170 Rab40b protein_coding 123 ENSMUSG00000025207.15 ENSMUSG00000025207 Sema4g protein_coding 124 ENSMUSG00000025330.6 ENSMUSG00000025330 Padi4 protein_coding 125 ENSMUSG00000025351.14 ENSMUSG00000025351 Cd63 protein_coding 126 ENSMUSG00000025375.15 ENSMUSG00000025375 Aatk protein_coding 127 ENSMUSG00000025608.9 ENSMUSG00000025608 Podxl protein_coding 128 ENSMUSG00000025804.5 ENSMUSG00000025804 Ccr1 protein_coding 129 ENSMUSG00000025877.14 ENSMUSG00000025877 Hk3 protein_coding 130 ENSMUSG00000025887.10 ENSMUSG00000025887 Casp12 protein_coding 131 ENSMUSG00000025969.15 ENSMUSG00000025969 Nrp2 protein_coding 132 ENSMUSG00000026177.11 ENSMUSG00000026177 Slc11a1 protein_coding 133 ENSMUSG00000026180.8 ENSMUSG00000026180 Cxcr2 protein_coding 134 ENSMUSG00000026193.15 ENSMUSG00000026193 Fn1 protein_coding 135 ENSMUSG00000026271.15 ENSMUSG00000026271 Gpr35 protein_coding 136 ENSMUSG00000026303.6 ENSMUSG00000026303 Mlph protein_coding 137 ENSMUSG00000026315.13 ENSMUSG00000026315 Serpinb8 protein_coding 138 ENSMUSG00000026357.3 ENSMUSG00000026357 Rgs18 protein_coding 139 ENSMUSG00000026365.15 ENSMUSG00000026365 Cfh protein_coding 140 ENSMUSG00000026398.14 ENSMUSG00000026398 Nr5a2 protein_coding 141 ENSMUSG00000026450.14 ENSMUSG00000026450 Chit1 protein_coding 142 ENSMUSG00000026579.8 ENSMUSG00000026579 F5 protein_coding 143 ENSMUSG00000026580.16 ENSMUSG00000026580 Selp protein_coding 144 ENSMUSG00000026822.14 ENSMUSG00000026822 Lcn2 protein_coding 145 ENSMUSG00000026835.15 ENSMUSG00000026835 Fcnb protein_coding 146 ENSMUSG00000026896.14 ENSMUSG00000026896 Ifih1 protein_coding 147 ENSMUSG00000026928.14 ENSMUSG00000026928 Card9 protein_coding 148 ENSMUSG00000026938.10 ENSMUSG00000026938 Fcna protein_coding 149 ENSMUSG00000026986.14 ENSMUSG00000026986 Hnmt protein_coding

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

150 ENSMUSG00000027071.14 ENSMUSG00000027071 P2rx3 protein_coding 151 ENSMUSG00000027322.11 ENSMUSG00000027322 Siglec1 protein_coding 152 ENSMUSG00000027359.16 ENSMUSG00000027359 Slc27a2 protein_coding 153 ENSMUSG00000027750.16 ENSMUSG00000027750 Postn protein_coding 154 ENSMUSG00000027803.14 ENSMUSG00000027803 Wwtr1 protein_coding 155 ENSMUSG00000027831.9 ENSMUSG00000027831 Veph1 protein_coding 156 ENSMUSG00000027962.14 ENSMUSG00000027962 Vcam1 protein_coding 157 ENSMUSG00000028125.14 ENSMUSG00000028125 Abca4 protein_coding 158 ENSMUSG00000028497.12 ENSMUSG00000028497 Hacd4 protein_coding 159 ENSMUSG00000028655.11 ENSMUSG00000028655 Mfsd2a protein_coding 160 ENSMUSG00000028717.12 ENSMUSG00000028717 Tal1 protein_coding 161 ENSMUSG00000028859.14 ENSMUSG00000028859 Csf3r protein_coding 162 ENSMUSG00000028874.14 ENSMUSG00000028874 Fgr protein_coding 163 ENSMUSG00000028885.8 ENSMUSG00000028885 Smpdl3b protein_coding 164 ENSMUSG00000029086.15 ENSMUSG00000029086 Prom1 protein_coding 165 ENSMUSG00000029108.14 ENSMUSG00000029108 Pcdh7 protein_coding 166 ENSMUSG00000029205.12 ENSMUSG00000029205 Chrna9 protein_coding 167 ENSMUSG00000029490.3 ENSMUSG00000029490 Mfsd7a protein_coding 168 ENSMUSG00000029561.17 ENSMUSG00000029561 Oasl2 protein_coding 169 ENSMUSG00000029596.13 ENSMUSG00000029596 Sdsl protein_coding 170 ENSMUSG00000029602.11 ENSMUSG00000029602 Rasal1 protein_coding 171 ENSMUSG00000029716.13 ENSMUSG00000029716 Tfr2 protein_coding 172 ENSMUSG00000029781.7 ENSMUSG00000029781 Fkbp9 protein_coding 173 ENSMUSG00000029797.13 ENSMUSG00000029797 Sspo protein_coding 174 ENSMUSG00000030054.4 ENSMUSG00000030054 Gp9 protein_coding 175 ENSMUSG00000030117.5 ENSMUSG00000030117 Gdf3 protein_coding 176 ENSMUSG00000030137.8 ENSMUSG00000030137 Tuba8 protein_coding 177 ENSMUSG00000030142.10 ENSMUSG00000030142 Clec4e protein_coding 178 ENSMUSG00000030144.4 ENSMUSG00000030144 Clec4d protein_coding 179 ENSMUSG00000030148.15 ENSMUSG00000030148 Clec4a2 protein_coding 180 ENSMUSG00000030159.15 ENSMUSG00000030159 Clec1b protein_coding 181 ENSMUSG00000030208.15 ENSMUSG00000030208 Emp1 protein_coding 182 ENSMUSG00000030214.7 ENSMUSG00000030214 Plbd1 protein_coding 183 ENSMUSG00000030340.16 ENSMUSG00000030340 Scnn1a protein_coding 184 ENSMUSG00000030341.17 ENSMUSG00000030341 Tnfrsf1a protein_coding 185 ENSMUSG00000030342.8 ENSMUSG00000030342 Cd9 protein_coding 186 ENSMUSG00000030427.17 ENSMUSG00000030427 Lilra6 protein_coding 187 ENSMUSG00000030554.16 ENSMUSG00000030554 Synm protein_coding 188 ENSMUSG00000030711.15 ENSMUSG00000030711 Sult1a1 protein_coding 189 ENSMUSG00000030717.9 ENSMUSG00000030717 Nupr1 protein_coding 190 ENSMUSG00000030786.18 ENSMUSG00000030786 Itgam protein_coding 191 ENSMUSG00000031137.17 ENSMUSG00000031137 Fgf13 protein_coding 192 ENSMUSG00000031142.17 ENSMUSG00000031142 Cacna1f protein_coding 193 ENSMUSG00000031189.12 ENSMUSG00000031189 Aff2 protein_coding 194 ENSMUSG00000031257.14 ENSMUSG00000031257 Nox1 protein_coding 195 ENSMUSG00000031298.15 ENSMUSG00000031298 Adgrg2 protein_coding 196 ENSMUSG00000031375.17 ENSMUSG00000031375 Bgn protein_coding 197 ENSMUSG00000031400.10 ENSMUSG00000031400 G6pdx protein_coding 198 ENSMUSG00000031428.11 ENSMUSG00000031428 Zcchc18 protein_coding 199 ENSMUSG00000031444.16 ENSMUSG00000031444 F10 protein_coding 200 ENSMUSG00000031584.16 ENSMUSG00000031584 Gsr protein_coding

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

201 ENSMUSG00000031722.10 ENSMUSG00000031722 Hp protein_coding 202 ENSMUSG00000031786.7 ENSMUSG00000031786 Drc7 protein_coding 203 ENSMUSG00000032062.2 ENSMUSG00000032062 2310030G06Rik protein_coding 204 ENSMUSG00000032128.15 ENSMUSG00000032128 Robo3 protein_coding 205 ENSMUSG00000032193.9 ENSMUSG00000032193 Ldlr protein_coding 206 ENSMUSG00000032202.11 ENSMUSG00000032202 Rab27a protein_coding 207 ENSMUSG00000032204.13 ENSMUSG00000032204 Aqp9 protein_coding 208 ENSMUSG00000032369.13 ENSMUSG00000032369 Plscr1 protein_coding 209 ENSMUSG00000032372.14 ENSMUSG00000032372 Plscr2 protein_coding 210 ENSMUSG00000032375.15 ENSMUSG00000032375 Aph1b protein_coding 211 ENSMUSG00000032484.8 ENSMUSG00000032484 Ngp protein_coding 212 ENSMUSG00000032496.7 ENSMUSG00000032496 Ltf protein_coding 213 ENSMUSG00000032503.18 ENSMUSG00000032503 Arpp21 protein_coding 214 ENSMUSG00000032531.15 ENSMUSG00000032531 Amotl2 protein_coding 215 ENSMUSG00000032556.11 ENSMUSG00000032556 Bfsp2 protein_coding 216 ENSMUSG00000032661.9 ENSMUSG00000032661 Oas3 protein_coding 217 ENSMUSG00000032702.16 ENSMUSG00000032702 Kank1 protein_coding 218 ENSMUSG00000032845.15 ENSMUSG00000032845 Alpk2 protein_coding 219 ENSMUSG00000032854.12 ENSMUSG00000032854 Ugt8a protein_coding 220 ENSMUSG00000032864.4 ENSMUSG00000032864 Rag2 protein_coding 221 ENSMUSG00000032915.6 ENSMUSG00000032915 Adgre4 protein_coding 222 ENSMUSG00000032936.13 ENSMUSG00000032936 Camkv protein_coding 223 ENSMUSG00000033082.10 ENSMUSG00000033082 Clec1a protein_coding 224 ENSMUSG00000033191.14 ENSMUSG00000033191 Tie1 protein_coding 225 ENSMUSG00000033255.8 ENSMUSG00000033255 Gm5134 protein_coding 226 ENSMUSG00000033763.14 ENSMUSG00000033763 Mtss1l protein_coding 227 ENSMUSG00000033777.4 ENSMUSG00000033777 Tlr13 protein_coding 228 ENSMUSG00000034271.16 ENSMUSG00000034271 Jdp2 protein_coding 229 ENSMUSG00000034486.8 ENSMUSG00000034486 Gbx2 protein_coding 230 ENSMUSG00000034641.2 ENSMUSG00000034641 Cd300ld protein_coding 231 ENSMUSG00000034648.9 ENSMUSG00000034648 Lrrn1 protein_coding 232 ENSMUSG00000034652.12 ENSMUSG00000034652 Cd300a protein_coding 233 ENSMUSG00000034664.13 ENSMUSG00000034664 Itga2b protein_coding 234 ENSMUSG00000034780.6 ENSMUSG00000034780 B3galt1 protein_coding 235 ENSMUSG00000034858.16 ENSMUSG00000034858 Fam214a protein_coding 236 ENSMUSG00000034957.10 ENSMUSG00000034957 Cebpa protein_coding 237 ENSMUSG00000035004.3 ENSMUSG00000035004 Igsf6 protein_coding 238 ENSMUSG00000035451.7 ENSMUSG00000035451 Foxa1 protein_coding 239 ENSMUSG00000035493.10 ENSMUSG00000035493 Tgfbi protein_coding 240 ENSMUSG00000036273.15 ENSMUSG00000036273 Lrrk2 protein_coding 241 ENSMUSG00000036295.5 ENSMUSG00000036295 Lrrn3 protein_coding 242 ENSMUSG00000036322.10 ENSMUSG00000036322 H2-Ea-ps unprocessed_pseudogene 243 ENSMUSG00000036377.18 ENSMUSG00000036377 C530008M17Rik protein_coding 244 ENSMUSG00000036469.16 ENSMUSG00000036469 43525 protein_coding 245 ENSMUSG00000036523.16 ENSMUSG00000036523 Greb1 protein_coding 246 ENSMUSG00000036718.17 ENSMUSG00000036718 Micall2 protein_coding 247 ENSMUSG00000036887.5 ENSMUSG00000036887 C1qa protein_coding 248 ENSMUSG00000036896.5 ENSMUSG00000036896 C1qc protein_coding 249 ENSMUSG00000037095.8 ENSMUSG00000037095 Lrg1 protein_coding 250 ENSMUSG00000037336.14 ENSMUSG00000037336 Mfsd2b protein_coding 251 ENSMUSG00000037348.15 ENSMUSG00000037348 Paqr7 protein_coding

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

252 ENSMUSG00000037366.14 ENSMUSG00000037366 Pafah2 protein_coding 253 ENSMUSG00000037492.16 ENSMUSG00000037492 Zmat4 protein_coding 254 ENSMUSG00000037784.14 ENSMUSG00000037784 Dzip1l protein_coding 255 ENSMUSG00000037820.15 ENSMUSG00000037820 Tgm2 protein_coding 256 ENSMUSG00000038068.15 ENSMUSG00000038068 Rnf144b protein_coding 257 ENSMUSG00000038168.5 ENSMUSG00000038168 P3h2 protein_coding 258 ENSMUSG00000038188.17 ENSMUSG00000038188 Scarf1 protein_coding 259 ENSMUSG00000038357.10 ENSMUSG00000038357 Camp protein_coding 260 ENSMUSG00000038527.9 ENSMUSG00000038527 C1rl protein_coding 261 ENSMUSG00000038738.15 ENSMUSG00000038738 Shank1 protein_coding 262 ENSMUSG00000038843.17 ENSMUSG00000038843 Gcnt1 protein_coding 263 ENSMUSG00000039037.5 ENSMUSG00000039037 St6galnac5 protein_coding 264 ENSMUSG00000039084.8 ENSMUSG00000039084 Chad protein_coding 265 ENSMUSG00000039126.10 ENSMUSG00000039126 Prune2 protein_coding 266 ENSMUSG00000039270.9 ENSMUSG00000039270 Megf9 protein_coding 267 ENSMUSG00000039542.16 ENSMUSG00000039542 Ncam1 protein_coding 268 ENSMUSG00000039699.13 ENSMUSG00000039699 Batf2 protein_coding 269 ENSMUSG00000039813.14 ENSMUSG00000039813 Tbc1d2 protein_coding 270 ENSMUSG00000040152.8 ENSMUSG00000040152 Thbs1 protein_coding 271 ENSMUSG00000040522.5 ENSMUSG00000040522 Tlr8 protein_coding 272 ENSMUSG00000040562.12 ENSMUSG00000040562 Gstm2 protein_coding 273 ENSMUSG00000040605.7 ENSMUSG00000040605 Bace2 protein_coding 274 ENSMUSG00000040690.15 ENSMUSG00000040690 Col16a1 protein_coding 275 ENSMUSG00000041324.14 ENSMUSG00000041324 Inhba protein_coding 276 ENSMUSG00000041362.16 ENSMUSG00000041362 Shtn1 protein_coding 277 ENSMUSG00000041481.16 ENSMUSG00000041481 Serpina3g protein_coding 278 ENSMUSG00000041548.4 ENSMUSG00000041548 Hspb8 protein_coding 279 ENSMUSG00000041598.7 ENSMUSG00000041598 Cdc42ep4 protein_coding 280 ENSMUSG00000042042.14 ENSMUSG00000042042 Csgalnact2 protein_coding 281 ENSMUSG00000042249.11 ENSMUSG00000042249 Grk3 protein_coding 282 ENSMUSG00000042268.10 ENSMUSG00000042268 Slc26a9 protein_coding 283 ENSMUSG00000042453.14 ENSMUSG00000042453 Reln protein_coding 284 ENSMUSG00000042659.15 ENSMUSG00000042659 Arrdc4 protein_coding 285 ENSMUSG00000042671.12 ENSMUSG00000042671 Rgs8 protein_coding 286 ENSMUSG00000042757.16 ENSMUSG00000042757 Tmem108 protein_coding 287 ENSMUSG00000043557.15 ENSMUSG00000043557 Mdga1 protein_coding 288 ENSMUSG00000043587.15 ENSMUSG00000043587 Pxylp1 protein_coding 289 ENSMUSG00000043740.15 ENSMUSG00000043740 B430306N03Rik protein_coding 290 ENSMUSG00000043832.13 ENSMUSG00000043832 Clec4a3 protein_coding 291 ENSMUSG00000043939.15 ENSMUSG00000043939 A530064D06Rik protein_coding 292 ENSMUSG00000044052.3 ENSMUSG00000044052 Ccr10 protein_coding 293 ENSMUSG00000044092.8 ENSMUSG00000044092 C130050O18Rik protein_coding 294 ENSMUSG00000044447.5 ENSMUSG00000044447 Dock5 protein_coding 295 ENSMUSG00000044811.13 ENSMUSG00000044811 Cd300c2 protein_coding 296 ENSMUSG00000045551.7 ENSMUSG00000045551 Fpr1 protein_coding 297 ENSMUSG00000045658.16 ENSMUSG00000045658 Pid1 protein_coding 298 ENSMUSG00000045763.8 ENSMUSG00000045763 Basp1 protein_coding 299 ENSMUSG00000045954.7 ENSMUSG00000045954 Cavin2 protein_coding 300 ENSMUSG00000046159.16 ENSMUSG00000046159 Chrm3 protein_coding 301 ENSMUSG00000046245.13 ENSMUSG00000046245 Pilra protein_coding 302 ENSMUSG00000046480.6 ENSMUSG00000046480 Scn4b protein_coding

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

303 ENSMUSG00000046593.3 ENSMUSG00000046593 Tmem215 protein_coding 304 ENSMUSG00000046598.15 ENSMUSG00000046598 Bdh1 protein_coding 305 ENSMUSG00000047250.13 ENSMUSG00000047250 Ptgs1 protein_coding 306 ENSMUSG00000047953.7 ENSMUSG00000047953 Gp5 protein_coding 307 ENSMUSG00000048376.6 ENSMUSG00000048376 F2r protein_coding 308 ENSMUSG00000048442.15 ENSMUSG00000048442 Smim5 protein_coding 309 ENSMUSG00000048498.7 ENSMUSG00000048498 Cd300e protein_coding 310 ENSMUSG00000048621.3 ENSMUSG00000048621 Gm6377 protein_coding 311 ENSMUSG00000049037.8 ENSMUSG00000049037 Clec4a1 protein_coding 312 ENSMUSG00000049115.15 ENSMUSG00000049115 Agtr1a protein_coding 313 ENSMUSG00000049130.6 ENSMUSG00000049130 C5ar1 protein_coding 314 ENSMUSG00000049577.15 ENSMUSG00000049577 Zfpm1 protein_coding 315 ENSMUSG00000049971.17 ENSMUSG00000049971 Glt1d1 protein_coding 316 ENSMUSG00000049988.5 ENSMUSG00000049988 Lrrc25 protein_coding 317 ENSMUSG00000049999.4 ENSMUSG00000049999 Ppp1r3d protein_coding 318 ENSMUSG00000050064.14 ENSMUSG00000050064 Zfp697 protein_coding 319 ENSMUSG00000050147.9 ENSMUSG00000050147 F2rl3 protein_coding 320 ENSMUSG00000050335.17 ENSMUSG00000050335 Lgals3 protein_coding 321 ENSMUSG00000050966.9 ENSMUSG00000050966 Lin28a protein_coding 322 ENSMUSG00000051051.7 ENSMUSG00000051051 Olfr523 protein_coding 323 ENSMUSG00000051397.5 ENSMUSG00000051397 Tacstd2 protein_coding 324 ENSMUSG00000051439.6 ENSMUSG00000051439 Cd14 protein_coding 325 ENSMUSG00000051490.2 ENSMUSG00000051490 Foxd4 protein_coding 326 ENSMUSG00000051682.15 ENSMUSG00000051682 Treml4 protein_coding 327 ENSMUSG00000051748.2 ENSMUSG00000051748 Wfdc21 protein_coding 328 ENSMUSG00000051910.13 ENSMUSG00000051910 Sox6 protein_coding 329 ENSMUSG00000052212.6 ENSMUSG00000052212 Cd177 protein_coding 330 ENSMUSG00000052270.7 ENSMUSG00000052270 Fpr2 protein_coding 331 ENSMUSG00000052396.7 ENSMUSG00000052396 Mogat2 protein_coding 332 ENSMUSG00000052534.15 ENSMUSG00000052534 Pbx1 protein_coding 333 ENSMUSG00000052560.15 ENSMUSG00000052560 Cpne8 protein_coding 334 ENSMUSG00000052749.9 ENSMUSG00000052749 Trim30b protein_coding 335 ENSMUSG00000053101.3 ENSMUSG00000053101 Gpr141 protein_coding 336 ENSMUSG00000053279.7 ENSMUSG00000053279 Aldh1a1 protein_coding 337 ENSMUSG00000053338.9 ENSMUSG00000053338 Tarm1 protein_coding 338 ENSMUSG00000053414.8 ENSMUSG00000053414 Hunk protein_coding 339 ENSMUSG00000053819.16 ENSMUSG00000053819 Camk2d protein_coding 340 ENSMUSG00000053931.11 ENSMUSG00000053931 Cnn3 protein_coding 341 ENSMUSG00000054641.10 ENSMUSG00000054641 Mmrn1 protein_coding 342 ENSMUSG00000054672.13 ENSMUSG00000054672 5830411N06Rik protein_coding 343 ENSMUSG00000054889.10 ENSMUSG00000054889 Dsp protein_coding 344 ENSMUSG00000055541.17 ENSMUSG00000055541 Lair1 protein_coding 345 ENSMUSG00000055546.6 ENSMUSG00000055546 Timd4 protein_coding 346 ENSMUSG00000055639.16 ENSMUSG00000055639 Dach1 protein_coding 347 ENSMUSG00000056025.12 ENSMUSG00000056025 Clca3a1 protein_coding 348 ENSMUSG00000056073.16 ENSMUSG00000056073 Grik2 protein_coding 349 ENSMUSG00000056529.7 ENSMUSG00000056529 Ptafr protein_coding 350 ENSMUSG00000056602.11 ENSMUSG00000056602 Fry protein_coding 351 ENSMUSG00000056973.6 ENSMUSG00000056973 Ces1d protein_coding 352 ENSMUSG00000057098.14 ENSMUSG00000057098 Ebf1 protein_coding 353 ENSMUSG00000057439.12 ENSMUSG00000057439 Kir3dl2 protein_coding

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

354 ENSMUSG00000057606.14 ENSMUSG00000057606 Colq protein_coding 355 ENSMUSG00000057777.4 ENSMUSG00000057777 Mab21l2 protein_coding 356 ENSMUSG00000058099.16 ENSMUSG00000058099 Nfam1 protein_coding 357 ENSMUSG00000058624.12 ENSMUSG00000058624 Gda protein_coding 358 ENSMUSG00000058626.16 ENSMUSG00000058626 Capn11 protein_coding 359 ENSMUSG00000058740.14 ENSMUSG00000058740 Kcnt1 protein_coding 360 ENSMUSG00000058818.13 ENSMUSG00000058818 Pirb protein_coding 361 ENSMUSG00000059089.4 ENSMUSG00000059089 Fcgr4 protein_coding 362 ENSMUSG00000059108.4 ENSMUSG00000059108 Ifitm6 protein_coding 363 ENSMUSG00000059280.4 ENSMUSG00000059280 Vpreb2 protein_coding 364 ENSMUSG00000059900.14 ENSMUSG00000059900 Tmem40 protein_coding 365 ENSMUSG00000060063.9 ENSMUSG00000060063 Alox5ap protein_coding 366 ENSMUSG00000060206.11 ENSMUSG00000060206 Zfp462 protein_coding 367 ENSMUSG00000060402.7 ENSMUSG00000060402 Chst8 protein_coding 368 ENSMUSG00000060487.7 ENSMUSG00000060487 Samd5 protein_coding 369 ENSMUSG00000061068.7 ENSMUSG00000061068 Mcpt4 protein_coding 370 ENSMUSG00000061086.12 ENSMUSG00000061086 Myl4 protein_coding 371 ENSMUSG00000061132.13 ENSMUSG00000061132 Blnk protein_coding 372 ENSMUSG00000061311.6 ENSMUSG00000061311 Rag1 protein_coding 373 ENSMUSG00000062127.11 ENSMUSG00000062127 Cttnbp2nl protein_coding 374 ENSMUSG00000062995.12 ENSMUSG00000062995 Ica1 protein_coding 375 ENSMUSG00000063109.13 ENSMUSG00000063109 Dgkeos antisense 376 ENSMUSG00000063193.8 ENSMUSG00000063193 Cd300lb protein_coding 377 ENSMUSG00000063234.5 ENSMUSG00000063234 Gpr84 protein_coding 378 ENSMUSG00000064246.10 ENSMUSG00000064246 Chil1 protein_coding 379 ENSMUSG00000066684.10 ENSMUSG00000066684 Pilrb1 protein_coding 380 ENSMUSG00000067614.5 ENSMUSG00000067614 Krt86 protein_coding 381 ENSMUSG00000067767.5 ENSMUSG00000067767 Clec4b2 protein_coding 382 ENSMUSG00000068079.5 ENSMUSG00000068079 Tcf15 protein_coding 383 ENSMUSG00000068245.14 ENSMUSG00000068245 Phf11d protein_coding 384 ENSMUSG00000069515.6 ENSMUSG00000069515 Lyz1 protein_coding 385 ENSMUSG00000069516.8 ENSMUSG00000069516 Lyz2 protein_coding 386 ENSMUSG00000069607.4 ENSMUSG00000069607 Cd300ld3 protein_coding 387 ENSMUSG00000070348.5 ENSMUSG00000070348 Ccnd1 protein_coding 388 ENSMUSG00000070476.10 ENSMUSG00000070476 Fam217b protein_coding 389 ENSMUSG00000070576.4 ENSMUSG00000070576 Mn1 protein_coding 390 ENSMUSG00000070868.11 ENSMUSG00000070868 Skint3 protein_coding 391 ENSMUSG00000070873.5 ENSMUSG00000070873 Lilra5 protein_coding 392 ENSMUSG00000071203.6 ENSMUSG00000071203 Naip5 protein_coding 393 ENSMUSG00000071637.5 ENSMUSG00000071637 Cebpd protein_coding 394 ENSMUSG00000071714.7 ENSMUSG00000071714 Csf2rb2 protein_coding 395 ENSMUSG00000072769.6 ENSMUSG00000072769 Gm10419 lincRNA 396 ENSMUSG00000072875.2 ENSMUSG00000072875 Gpr27 protein_coding 397 ENSMUSG00000072949.6 ENSMUSG00000072949 Acot1 protein_coding 398 ENSMUSG00000074259.10 ENSMUSG00000074259 Gramd2 protein_coding 399 ENSMUSG00000074272.10 ENSMUSG00000074272 Ceacam1 protein_coding 400 ENSMUSG00000074342.3 ENSMUSG00000074342 I830077J02Rik protein_coding 401 ENSMUSG00000074417.9 ENSMUSG00000074417 Gm14548 protein_coding 402 ENSMUSG00000074575.4 ENSMUSG00000074575 Kcng1 protein_coding 403 ENSMUSG00000074785.5 ENSMUSG00000074785 Plxnc1 protein_coding 404 ENSMUSG00000075588.6 ENSMUSG00000075588 Hoxb2 protein_coding

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

405 ENSMUSG00000076523.2 ENSMUSG00000076523 Igkv15-103 IG_V_gene 406 ENSMUSG00000076530.4 ENSMUSG00000076530 Igkv11-106 IG_V_pseudogene 407 ENSMUSG00000076547.2 ENSMUSG00000076547 Igkv4-70 IG_V_gene 408 ENSMUSG00000076578.3 ENSMUSG00000076578 Igkv6-29 IG_V_gene 409 ENSMUSG00000076653.4 ENSMUSG00000076653 Ighv7-2 IG_V_gene 410 ENSMUSG00000076665.4 ENSMUSG00000076665 Ighv7-1 IG_V_gene 411 ENSMUSG00000076670.4 ENSMUSG00000076670 Ighv3-5 IG_V_gene 412 ENSMUSG00000076672.7 ENSMUSG00000076672 Ighv3-6 IG_V_gene 413 ENSMUSG00000076695.7 ENSMUSG00000076695 Ighv1-18 IG_V_gene 414 ENSMUSG00000078122.4 ENSMUSG00000078122 F630028O10Rik antisense 415 ENSMUSG00000078452.10 ENSMUSG00000078452 Raet1d protein_coding 416 ENSMUSG00000078612.9 ENSMUSG00000078612 Fyb2 protein_coding 417 ENSMUSG00000078771.10 ENSMUSG00000078771 Evi2a protein_coding 418 ENSMUSG00000078963.2 ENSMUSG00000078963 Hsbp1l1 protein_coding 419 ENSMUSG00000079157.4 ENSMUSG00000079157 Fam155a protein_coding 420 ENSMUSG00000079164.8 ENSMUSG00000079164 Tlr5 protein_coding 421 ENSMUSG00000079481.11 ENSMUSG00000079481 Nhsl2 protein_coding 422 ENSMUSG00000079547.3 ENSMUSG00000079547 H2-DMb1 protein_coding 423 ENSMUSG00000079606.1 ENSMUSG00000079606 Gm595 protein_coding 424 ENSMUSG00000080917.2 ENSMUSG00000080917 Gm15925 unprocessed_pseudogene 425 ENSMUSG00000081665.2 ENSMUSG00000081665 Gm15922 polymorphic_pseudogene 426 ENSMUSG00000081723.1 ENSMUSG00000081723 Gm15931 unprocessed_pseudogene 427 ENSMUSG00000085786.1 ENSMUSG00000085786 Gm15987 antisense 428 ENSMUSG00000085890.7 ENSMUSG00000085890 Tnfsf13os antisense 429 ENSMUSG00000086179.1 ENSMUSG00000086179 Gm14317 lincRNA 430 ENSMUSG00000086236.9 ENSMUSG00000086236 5830418P13Rik antisense 431 ENSMUSG00000087187.1 ENSMUSG00000087187 Gm13431 lincRNA 432 ENSMUSG00000089942.9 ENSMUSG00000089942 Pira2 protein_coding 433 ENSMUSG00000090214.8 ENSMUSG00000090214 Gm15657 antisense 434 ENSMUSG00000091712.2 ENSMUSG00000091712 Sec14l5 protein_coding 435 ENSMUSG00000092572.7 ENSMUSG00000092572 Serpinb10 polymorphic_pseudogene 436 ENSMUSG00000094028.1 ENSMUSG00000094028 Ighd4-1 IG_D_gene 437 ENSMUSG00000094164.2 ENSMUSG00000094164 Ighv2-3 IG_V_gene 438 ENSMUSG00000094504.3 ENSMUSG00000094504 Gm5294 protein_coding 439 ENSMUSG00000094940.1 ENSMUSG00000094940 Ighv1-84 IG_V_gene 440 ENSMUSG00000095115.2 ENSMUSG00000095115 Itpripl2 protein_coding 441 ENSMUSG00000095134.2 ENSMUSG00000095134 Mid1-ps1 unprocessed_pseudogene 442 ENSMUSG00000095197.6 ENSMUSG00000095197 Ighv1-59 IG_V_gene 443 ENSMUSG00000095204.6 ENSMUSG00000095204 Ighv1-52 IG_V_gene 444 ENSMUSG00000095519.2 ENSMUSG00000095519 Ighv1-66 IG_V_gene 445 ENSMUSG00000095609.2 ENSMUSG00000095609 Gm21188 protein_coding 446 ENSMUSG00000095633.2 ENSMUSG00000095633 Igkv4-58 IG_V_gene 447 ENSMUSG00000095788.6 ENSMUSG00000095788 Sirpb1a protein_coding 448 ENSMUSG00000096355.2 ENSMUSG00000096355 Ighv8-4 IG_V_gene 449 ENSMUSG00000096490.1 ENSMUSG00000096490 Igkv10-94 IG_V_gene 450 ENSMUSG00000096498.3 ENSMUSG00000096498 Ighv2-5 IG_V_gene 451 ENSMUSG00000096824.2 ENSMUSG00000096824 Ighv2-7 IG_V_gene 452 ENSMUSG00000097378.8 ENSMUSG00000097378 B230208H11Rik lincRNA 453 ENSMUSG00000097462.7 ENSMUSG00000097462 9530026P05Rik antisense 454 ENSMUSG00000097585.2 ENSMUSG00000097585 E230029C05Rik processed_transcript 455 ENSMUSG00000098197.1 ENSMUSG00000098197 BC051537 antisense

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

456 ENSMUSG00000100459.6 ENSMUSG00000100459 Gm5833 lincRNA 457 ENSMUSG00000101389.1 ENSMUSG00000101389 Ms4a4a protein_coding 458 ENSMUSG00000102332.1 ENSMUSG00000102332 Gm19331 lincRNA 459 ENSMUSG00000102524.1 ENSMUSG00000102524 Ighv1-2 IG_V_pseudogene 460 ENSMUSG00000103033.1 ENSMUSG00000103033 Ighv5-12-4 IG_V_gene 461 ENSMUSG00000103168.1 ENSMUSG00000103168 Gm30948 lincRNA 462 ENSMUSG00000103395.1 ENSMUSG00000103395 Ighv1-27 IG_V_pseudogene 463 ENSMUSG00000103586.5 ENSMUSG00000103586 5830405F06Rik lincRNA 464 ENSMUSG00000104554.1 ENSMUSG00000104554 Gm4610 antisense 465 ENSMUSG00000105363.1 ENSMUSG00000105363 Igkv11-114 IG_V_pseudogene 466 ENSMUSG00000105652.1 ENSMUSG00000105652 4930519L02Rik lincRNA 467 ENSMUSG00000105867.2 ENSMUSG00000105867 Gm42517 protein_coding 468 ENSMUSG00000106601.1 ENSMUSG00000106601 Ighv1-70 IG_V_pseudogene 469 ENSMUSG00000107317.1 ENSMUSG00000107317 Gm19719 antisense 470 ENSMUSG00000107849.1 ENSMUSG00000107849 Gm43904 lincRNA 471 ENSMUSG00000109245.1 ENSMUSG00000109245 Gm44860 TEC 472 ENSMUSG00000112023.1 ENSMUSG00000112023 Lilr4b protein_coding 473 ENSMUSG00000112148.1 ENSMUSG00000112148 Lilrb4a protein_coding 474 ENSMUSG00000113535.1 ENSMUSG00000113535 AU015791 lincRNA 475 ENSMUSG00000114608.1 ENSMUSG00000114608 Gm36161 lincRNA 476 ENSMUSG00000115919.1 ENSMUSG00000115919 Gm31583 lincRNA 477 ENSMUSG00000116114.1 ENSMUSG00000116114 Gm35853 antisense 478 ENSMUSG00000117315.1 ENSMUSG00000117315 AC154218.2 lincRNA

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

Bone Marrow-Derived LSK cells from 'F1-Lupus

Chromosome/scaffold.name Gene.start.(bp) Gene.end.(bp) 16 96422288 96443619 11 83175186 83190216 11 89035179 89066850 11 96292476 96301569 10 78030022 78043610 3 90612882 90624181 11 78397087 78422217 10 77052178 77166548 8 123423527 123463270 2 145675215 145887616 6 125546774 125686679 9 37528078 37538319 13 19591706 19619927 7 19696109 19699188 1 39371492 39478755 6 122727809 122801640 2 153108468 153151441 8 71988482 72009626 11 100956733 100970887 11 9191942 9684259 17 57358691 57483527 17 28769297 28780233 15 66929318 66969640 11 69420809 69549110 7 110868266 110982461 7 110768206 110812405 9 7558456 7568485 2 122765237 122809569 5 136054492 136064326 7 130936111 130985660 4 94739289 94874976 6 124430759 124464794 6 138140316 138156755 10 77907722 77970563 19 34668403 34747289 1 135434580 135607295 8 33516738 33585582 10 23102963 23350786 7 27356383 27447686 2 128698956 128802894 6 88193891 88207032 2 25399351 25409494 12 80167547 80260371 3 87357881 87371073 2 143915320 143943324 3 96282909 96293969 5 134220053 134229625

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

2 158306493 158332852 13 24327404 24477377 2 165374264 165388259 2 164940780 164955850 2 164839518 164857711 10 10545002 10558265 10 103367783 103419377 10 89574020 89621253 10 93640681 93747207 10 95385362 95417180 10 80295977 80318263 11 11930508 12038683 10 120141648 120202130 10 79664559 79668537 11 9118103 9136170 12 7977648 8016835 11 105967945 105989964 11 104608000 104670476 11 80154105 80178958 11 116105752 116127210 11 73304992 73329596 11 72999103 73015200 11 76019194 76027782 11 94343295 94392997 11 68209364 68400823 12 91633009 91788387 12 70190811 70231488 12 79130777 79156301 12 109541001 109571726 12 111417017 111431678 12 111442469 111455018 13 60601947 60763191 13 76384535 77031810 13 89655312 89742509 14 34410734 34503341 14 78277445 78308043 14 79984081 80023139 14 65968483 65981547 14 70890120 70979838 14 55941451 55944675 15 32920723 33034935 15 56665627 56694539 15 55307750 55520803 15 97711015 97731339 16 23965052 23988852 16 26356642 26371841 15 89499623 89560261 16 16416917 16600549 16 20308387 20325404 16 33794037 33819934 16 23224740 23360350

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

16 84949685 85173766 15 99778470 99875456 X 56731787 56793346 6 124841089 124857752 6 123229843 123247021 9 108826320 108852969 17 14279506 14404790 17 43568098 43612201 17 44078813 44086567 17 29318877 29329413 17 71252172 71311978 17 57203970 57228136 18 42637432 43059471 18 61105572 61132149 19 20373428 20390944 19 11586604 11604849 19 11067471 11081102 19 34122549 34166053 19 41029275 41059523 8 39581685 39642673 19 58235604 58455909 19 59260878 59296012 11 120948480 120960868 11 121356125 121388251 19 44989101 45003397 4 140745865 140774236 10 128900989 128912822 11 120007313 120047167 6 31519488 31563981 9 123962124 123968692 13 55005985 55021385 9 5345430 5373032 1 62703285 62818695 1 74375195 74386062 1 74153989 74161246 1 71585520 71653200 1 92950865 92986391 1 90915085 90951142 1 107590006 107610484 1 144752683 144775435 1 140084708 140183764 1 136842571 136960448 1 134111242 134151540 1 164151838 164220277 1 164115264 164150026 2 32384633 32388252 2 28076378 28084885 2 62595798 62646255 2 26352176 26360918 2 25624666 25628030 2 24002910 24049394

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

2 84998583 85037462 2 131069220 131086765 2 126552407 126588243 3 54361109 54391037 3 57455649 57575910 3 66053558 66296837 3 116109949 116129688 3 122044443 122180123 4 88396144 88438928 4 122946850 122961188 4 115056426 115071755 4 126024550 126044440 4 132974095 133001910 4 132732966 132757252 5 43993620 44102032 5 57717967 58133230 5 65934921 65977326 5 108441054 108448891 5 114896936 114912234 5 120458186 120472810 5 120648812 120679597 5 137569840 137587481 6 56832059 56879358 6 48448229 48501250 6 87778072 87779768 6 122605403 122610087 6 121210696 121226854 6 123281789 123289870 6 123262111 123275265 6 123106428 123143999 6 129397297 129409335 6 135362545 135383173 6 136612070 136661928 6 125320659 125344943 6 125349362 125362484 6 125460266 125494791 7 3908280 3915503 7 67730160 67759742 7 126672865 126676432 7 126623249 126630861 7 128062640 128118491 X 59062145 59568071 X 7607083 7635196 X 69360294 69868037 X 134086421 134221956 X 160390690 160498070 X 73483602 73495933 X 74409483 74429194 X 136993155 136998472 8 13037308 13056676 8 33652523 33698163

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

8 109575128 109579172 8 95055103 95078141 9 50739691 50746536 9 37415669 37433246 9 21723483 21749919 9 73044854 73097629 9 71110659 71168682 9 92249750 92272278 9 92275602 92297752 9 66775202 66795490 9 110419747 110423012 9 111019271 111042767 9 112065091 112235938 9 102716672 102733418 9 103424924 103480420 5 120753098 120777661 19 25236975 25434496 18 65265529 65393888 3 125865271 125938619 2 101624718 101632529 17 55749984 55853662 9 107935674 107949691 6 129424772 129452000 4 118471191 118490061 10 75954514 76009591 8 110721476 110741400 X 106143204 106160493 12 85599027 85639878 1 89927956 89931179 11 114982274 114989922 6 107529768 107570214 11 114890041 114904654 11 102453297 102470122 2 67565871 68122689 9 74952884 75032468 7 35119293 35121928 7 121064067 121074572 12 57540628 57546916 13 56609523 56639562 15 91673175 91816120 12 41451668 41486431 17 34342933 34344643 5 76656512 76873554 8 65617900 66471637 12 16670615 16800886 5 139706696 139736336 4 136895917 136898803 4 136889804 136893065 17 56119678 56122001 12 4862440 4874359 4 134496697 134510235

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

4 134396320 134427413 8 23636019 24156585 9 99629496 99669256 2 158116402 158146436 13 47122656 47247991 16 25959288 26105784 11 75513540 75526582 9 109847379 109849617 6 124493113 124510643 7 44310253 44360572 19 17326141 17356667 3 152817081 152982246 11 94565047 94569127 19 16956118 17223932 4 70427065 70534995 9 49502136 49798925 19 6140983 6172476 4 46604390 46650209 2 118111876 118127133 X 167242696 167264329 3 107981702 107986453 16 97356742 97442936 4 130047840 130099283 13 16011851 16031621 19 58973358 59076069 12 104236245 104241939 5 116408491 116422864 11 113726850 113751881 6 118107452 118139140 5 112910482 113015791 1 131744022 131771504 5 21884454 22344702 7 68736995 68749241 1 153653025 153700323 9 103482947 103761837 17 29827956 29970087 9 96823336 96892669 17 48316141 48327024 6 122952515 122969875 17 48149126 48167275 11 101172997 101175443 5 139405280 139415623 14 67752135 67933442 11 114996721 115001880 17 17876471 17883940 1 84036296 84364180 15 25363277 25413764 1 51289126 51302960 13 9875486 10360847 5 137821952 137836281 9 45138395 45154152

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

4 40472180 40477168 16 31422280 31458901 2 36230426 36252272 16 30307685 30310779 13 95601803 95618487 11 115899966 115906269 11 115051917 115062177 X 109196756 109200439 6 122921848 122934619 13 30336441 30382867 7 16246743 16259540 8 122282141 122337251 5 127632262 127709374 8 70616155 70621483 2 178411206 178414472 3 98382461 98753812 8 72761880 72763874 14 47367751 47386160 4 134003330 134018841 7 140173217 140178758 6 67534062 67535796 18 36725074 36726736 19 24898965 24901309 17 48264295 48275360 11 83746940 83752642 7 115470872 116038796 7 24743983 24760311 17 17887824 17893952 7 99219084 99238619 1 168119364 168432270 15 90487482 90679432 7 104355382 104369884 13 19749682 19824257 19 20492715 20643462 7 3486500 3502624 16 90386013 90499553 3 126596302 126846326 3 121426497 121458207 6 60924976 60989378 7 140247284 140300736 13 38151294 38198577 7 4003402 4063204 11 46810800 46844332 14 97786853 98169765 3 144729677 144760977 10 49094833 49788766 4 132564067 132582683 5 150118645 150497753 8 93166068 93197838 11 44617317 45008091 X 136448107 136544056

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

14 31523082 31591343 3 86545581 86548629 15 82992973 83033306 19 21391307 21473445 17 45630204 45659325 2 25863734 25918273 7 3711409 3720391 1 171018920 171029761 7 141015699 141017924 16 17980428 17981273 6 115729131 115762410 5 149264767 149288153 4 54945048 55083563 7 34674468 34812711 10 9622936 9675208 14 56059629 56062313 11 104550663 104595753 19 40928927 40994535 2 101638282 101649501 3 105001915 105053146 6 8630527 8778488 11 89064729 89069098 11 114922781 114934386 15 103308235 103310612 1 134182176 134190181 5 137852147 137858106 15 101473478 101479986 6 123172893 123204671 2 152143561 152149097 14 59347407 59365470 10 117287797 117292868 10 117277331 117282321 11 115042131 115048409 7 144929931 144939925 2 178414524 178424428 5 111417362 111457033 4 112232245 112300468 7 4237754 4243463 13 100211739 100246323 16 15887286 15891031 15 78282507 78305721 5 108367769 108378239 6 99692679 99695066 12 84009490 84018371 9 59680144 59718874 7 25461707 25477603 3 105924358 105932664 7 3884242 3898120 2 168260117 168281736 10 94790866 94944835 11 96350525 96354012

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

6 68437440 68437925 6 68339527 68339995 6 69267888 69268443 6 70138462 70139110 12 113912025 113912483 12 113896408 113896946 12 114262652 114263087 12 114288152 114288582 12 114682632 114683065 X 96239926 96243636 10 22360552 22374139 4 104913456 105016863 11 79526560 79530609 18 80229758 80247102 8 9205902 9771161 1 182954788 182976044 X 101849385 102092055 17 34153072 34160230 X 48841466 48877713 7 3788883 3799631 7 3731630 3739889 7 4274189 4282645 6 128951204 128975029 11 69682138 69691141 2 164550530 164559730 9 103423578 103461260 2 36216777 36222934 7 3836812 3845051 16 33770430 33796874 16 5147109 5187271 1 107529003 107549271 12 113430528 113430538 12 113611187 113611617 5 138820080 138821619 12 115980702 115981134 7 118485111 118491975 Y 90753057 90763485 12 115335082 115335514 12 115145487 115145919 12 115593110 115593591 13 120034605 120052194 6 69500254 69500786 3 15371653 15426520 12 115024026 115024459 6 68704508 68704978 12 113685482 113686045 12 113807314 113807752 10 12916648 12923090 6 92940329 93272979 7 89980723 90049069 17 34083843 34095309

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1 138640095 138682077 19 11375523 11392790 12 115386846 115397688 12 114469075 114469535 12 113762249 113762708 12 115262684 115287908 12 114804616 114805041 6 41055883 41063102 3 122377097 122391811 6 68164457 68164923 3 143017660 143040752 5 108366073 108367922 12 115691889 115692322 5 149282752 149287868 6 87776143 87777480 7 90030571 90032916 10 51480632 51486703 10 51490956 51496611 12 105513480 105515246 13 120010390 120018931 16 24085083 24090089 15 101322888 101405834 17 71144538 71181987

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

pus vs F1-Prediseased Female Mice' (|FC|1.5, FDR<0.05)

Gene.description -like [Source:MGI Symbol;Acc:MGI:1277979] schlafen 4 [Source:MGI Symbol;Acc:MGI:1329010] diacylglycerol kinase, epsilon [Source:MGI Symbol;Acc:MGI:1889276] B6 [Source:MGI Symbol;Acc:MGI:96187] (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) [Source:MGI Symb S100 calcium binding A6 (calcyclin) [Source:MGI Symbol;Acc:MGI:1339467] 13 (sodium-dependent dicarboxylate transporter), member 2 [Source:MGI Symbol;Acc:MGI collagen, type XVIII, alpha 1 [Source:MGI Symbol;Acc:MGI:88451] differentially expressed in FDCP 8 [Source:MGI Symbol;Acc:MGI:1346331] Ras and Rab interactor 2 [Source:MGI Symbol;Acc:MGI:1921280] Von Willebrand factor [Source:MGI Symbol;Acc:MGI:98941] endothelial cell-specific adhesion molecule [Source:MGI Symbol;Acc:MGI:1916774] ependymin related protein 1 (zebrafish) [Source:MGI Symbol;Acc:MGI:2145369] apolipoprotein E [Source:MGI Symbol;Acc:MGI:88057] TBC1 domain family, member 8 [Source:MGI Symbol;Acc:MGI:1927225] solute carrier family 2 (facilitated ), member 3 [Source:MGI Symbol;Acc:MGI:95757] hemopoietic cell kinase [Source:MGI Symbol;Acc:MGI:96052] cytochrome P450, family 4, subfamily f, polypeptide 18 [Source:MGI Symbol;Acc:MGI:1919304] caveolae associated 1 [Source:MGI Symbol;Acc:MGI:1277968] ATP-binding cassette, sub-family A (ABC1), member 13 [Source:MGI Symbol;Acc:MGI:2388707] adhesion -coupled E1 [Source:MGI Symbol;Acc:MGI:106912] mitogen-activated protein kinase 13 [Source:MGI Symbol;Acc:MGI:1346864] N- downstream regulated gene 1 [Source:MGI Symbol;Acc:MGI:1341799] dynein, axonemal, heavy chain 2 [Source:MGI Symbol;Acc:MGI:107731] MRV integration site 1 [Source:MGI Symbol;Acc:MGI:1338023] adenosine monophosphate deaminase 3 [Source:MGI Symbol;Acc:MGI:1096344] matrix metallopeptidase 8 [Source:MGI Symbol;Acc:MGI:1202395] sulfide quinone [Source:MGI Symbol;Acc:MGI:1929899] uroplakin 3B-like [Source:MGI Symbol;Acc:MGI:1916915] HtrA serine peptidase 1 [Source:MGI Symbol;Acc:MGI:1929076] TEK receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:98664] calsyntenin 3 [Source:MGI Symbol;Acc:MGI:2178323] microsomal glutathione S- 1 [Source:MGI Symbol;Acc:MGI:1913850] transient receptor potential cation channel, subfamily M, member 2 [Source:MGI Symbol;Acc:MGI:1351901] solute carrier family 16 (monocarboxylic acid transporters), member 12 [Source:MGI Symbol;Acc:MGI:2147716] neuron navigator 1 [Source:MGI Symbol;Acc:MGI:2183683] testis expressed gene 15 [Source:MGI Symbol;Acc:MGI:1934816] EYA transcriptional coactivator and 4 [Source:MGI Symbol;Acc:MGI:1337104] spectrin beta, non-erythrocytic 4 [Source:MGI Symbol;Acc:MGI:1890574] c-mer proto-oncogene tyrosine kinase [Source:MGI Symbol;Acc:MGI:96965] GATA binding protein 2 [Source:MGI Symbol;Acc:MGI:95662] neural proliferation, differentiation and control 1 [Source:MGI Symbol;Acc:MGI:1099802] actinin, alpha 1 [Source:MGI Symbol;Acc:MGI:2137706] CD5 antigen-like [Source:MGI Symbol;Acc:MGI:1334419] [Source:MGI Symbol;Acc:MGI:1929270] Fc receptor, IgG, high affinity I [Source:MGI Symbol;Acc:MGI:95498] neutrophil cytosolic factor 1 [Source:MGI Symbol;Acc:MGI:97283]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

lipopolysaccharide binding protein [Source:MGI Symbol;Acc:MGI:1098776] cytidine monophospho-N-acetylneuraminic acid hydroxylase [Source:MGI Symbol;Acc:MGI:103227] protein 334 [Source:MGI Symbol;Acc:MGI:2388656] matrix metallopeptidase 9 [Source:MGI Symbol;Acc:MGI:97011] phospholipid transfer protein [Source:MGI Symbol;Acc:MGI:103151] RAB32, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:1915094] solute carrier family 6 (neurotransmitter transporter), member 15 [Source:MGI Symbol;Acc:MGI:2143484] solute carrier family 17 (sodium-dependent inorganic phosphate ), member 8 [Source:MGI Symbo netrin 4 [Source:MGI Symbol;Acc:MGI:1888978] suppressor of cytokine signaling 2 [Source:MGI Symbol;Acc:MGI:1201787] adenomatosis polyposis coli 2 [Source:MGI Symbol;Acc:MGI:1346052] growth factor receptor bound protein 10 [Source:MGI Symbol;Acc:MGI:103232] interleukin-1 receptor-associated kinase 3 [Source:MGI Symbol;Acc:MGI:1921164] mucosal vascular addressin cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:103579] uridine phosphorylase 1 [Source:MGI Symbol;Acc:MGI:1097668] apolipoprotein B [Source:MGI Symbol;Acc:MGI:88052] angiotensin I converting (peptidyl-dipeptidase A) 1 [Source:MGI Symbol;Acc:MGI:87874] [Source:MGI Symbol;Acc:MGI:96612] ArfGAP with dual PH domains 2 [Source:MGI Symbol;Acc:MGI:2663075] tripartite motif-containing 47 [Source:MGI Symbol;Acc:MGI:1917374] aspartoacylase [Source:MGI Symbol;Acc:MGI:87914] purinergic receptor P2X, ligand-gated ion channel, 1 [Source:MGI Symbol;Acc:MGI:1098235] refilin B [Source:MGI Symbol;Acc:MGI:1923816] ATP-binding cassette, sub-family C (CFTR/MRP), member 3 [Source:MGI Symbol;Acc:MGI:1923658] netrin 1 [Source:MGI Symbol;Acc:MGI:105088] stonin 2 [Source:MGI Symbol;Acc:MGI:1918272] liver glycogen phosphorylase [Source:MGI Symbol;Acc:MGI:97829] arginase type II [Source:MGI Symbol;Acc:MGI:1330806] maternally expressed 3 [Source:MGI Symbol;Acc:MGI:1202886] exocyst complex component 3-like 4 [Source:MGI Symbol;Acc:MGI:1921363] tumor necrosis factor, alpha-induced protein 2 [Source:MGI Symbol;Acc:MGI:104960] death associated protein kinase 1 [Source:MGI Symbol;Acc:MGI:1916885] multiple C2 domains, transmembrane 1 [Source:MGI Symbol;Acc:MGI:1926021] versican [Source:MGI Symbol;Acc:MGI:102889] bone morphogenetic protein receptor, type 1A [Source:MGI Symbol;Acc:MGI:1338938] tumor necrosis factor (ligand) superfamily, member 11 [Source:MGI Symbol;Acc:MGI:1100089] olfactomedin 4 [Source:MGI Symbol;Acc:MGI:2685142] clusterin [Source:MGI Symbol;Acc:MGI:88423] glial cell line derived neurotrophic factor family receptor alpha 2 [Source:MGI Symbol;Acc:MGI:1195462] 1, mast cell [Source:MGI Symbol;Acc:MGI:96941] syndecan 2 [Source:MGI Symbol;Acc:MGI:1349165] hyaluronan synthase 2 [Source:MGI Symbol;Acc:MGI:107821] collagen, type XIV, alpha 1 [Source:MGI Symbol;Acc:MGI:1341272] , polyU-specific [Source:MGI Symbol;Acc:MGI:97746] leukemia/lymphoma 6 [Source:MGI Symbol;Acc:MGI:107187] claudin 1 [Source:MGI Symbol;Acc:MGI:1276109] SH3 and multiple repeat domains 3 [Source:MGI Symbol;Acc:MGI:1930016] FYVE, RhoGEF and PH domain containing 4 [Source:MGI Symbol;Acc:MGI:2183747] cytochrome P450, family 2, subfamily ab, polypeptide 1 [Source:MGI Symbol;Acc:MGI:3644957] mucin 13, epithelial transmembrane [Source:MGI Symbol;Acc:MGI:103190] beta galactoside alpha 2,6 sialyltransferase 1 [Source:MGI Symbol;Acc:MGI:108470]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

amyloid beta (A4) precursor protein [Source:MGI Symbol;Acc:MGI:88059] LIM domain and binding 1 [Source:MGI Symbol;Acc:MGI:1920992] four and a half LIM domains 1 [Source:MGI Symbol;Acc:MGI:1298387] prolyl 3-hydroxylase 3 [Source:MGI Symbol;Acc:MGI:1315208] C-type lectin domain family 4, member n [Source:MGI Symbol;Acc:MGI:1861231] cadherin, EGF LAG seven-pass G-type receptor 3 [Source:MGI Symbol;Acc:MGI:1858236] SPARC related modular calcium binding 2 [Source:MGI Symbol;Acc:MGI:1929881] A2, group VII (platelet-activating factor acetylhydrolase, plasma) [Source:MGI Symbol;Acc:MGI:13 ectonucleotide pyrophosphatase/ 5 [Source:MGI Symbol;Acc:MGI:1933830] peptidase inhibitor 16 [Source:MGI Symbol;Acc:MGI:1921366] elastin microfibril interfacer 2 [Source:MGI Symbol;Acc:MGI:2389136] complement component 3 [Source:MGI Symbol;Acc:MGI:88227] 2, regulatory subunit B, beta [Source:MGI Symbol;Acc:MGI:1920180] colony stimulating factor 1 receptor [Source:MGI Symbol;Acc:MGI:1339758] annexin A1 [Source:MGI Symbol;Acc:MGI:96819] membrane-spanning 4-domains, subfamily A, member 6D [Source:MGI Symbol;Acc:MGI:1916024] membrane-spanning 4-domains, subfamily A, member 8A [Source:MGI Symbol;Acc:MGI:1927657] ankyrin repeat domain 22 [Source:MGI Symbol;Acc:MGI:1277101] deoxynucleotidyltransferase, terminal [Source:MGI Symbol;Acc:MGI:98659] macrophage scavenger receptor 1 [Source:MGI Symbol;Acc:MGI:98257] glial cell line derived neurotrophic factor family receptor alpha 1 [Source:MGI Symbol;Acc:MGI:1100842] solute carrier family 18 (vesicular monoamine), member 2 [Source:MGI Symbol;Acc:MGI:106677] solute carrier family 16 (monocarboxylic acid transporters), member 3 [Source:MGI Symbol;Acc:MGI:1933438] Rab40B, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:2183451] sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semap peptidyl arginine deiminase, type IV [Source:MGI Symbol;Acc:MGI:1338898] CD63 antigen [Source:MGI Symbol;Acc:MGI:99529] apoptosis-associated tyrosine kinase [Source:MGI Symbol;Acc:MGI:1197518] podocalyxin-like [Source:MGI Symbol;Acc:MGI:1351317] chemokine (C-C motif) receptor 1 [Source:MGI Symbol;Acc:MGI:104618] hexokinase 3 [Source:MGI Symbol;Acc:MGI:2670962] caspase 12 [Source:MGI Symbol;Acc:MGI:1312922] 2 [Source:MGI Symbol;Acc:MGI:1100492] solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 [Source:MGI Symbol;Acc:M chemokine (C-X-C motif) receptor 2 [Source:MGI Symbol;Acc:MGI:105303] fibronectin 1 [Source:MGI Symbol;Acc:MGI:95566] G protein-coupled receptor 35 [Source:MGI Symbol;Acc:MGI:1929509] melanophilin [Source:MGI Symbol;Acc:MGI:2176380] serine (or cysteine) peptidase inhibitor, B, member 8 [Source:MGI Symbol;Acc:MGI:894657] regulator of G-protein signaling 18 [Source:MGI Symbol;Acc:MGI:1927498] complement component factor h [Source:MGI Symbol;Acc:MGI:88385] subfamily 5, group A, member 2 [Source:MGI Symbol;Acc:MGI:1346834] chitinase 1 (chitotriosidase) [Source:MGI Symbol;Acc:MGI:1919134] factor V [Source:MGI Symbol;Acc:MGI:88382] , platelet [Source:MGI Symbol;Acc:MGI:98280] lipocalin 2 [Source:MGI Symbol;Acc:MGI:96757] ficolin B [Source:MGI Symbol;Acc:MGI:1341158] interferon induced with helicase C domain 1 [Source:MGI Symbol;Acc:MGI:1918836] caspase recruitment domain family, member 9 [Source:MGI Symbol;Acc:MGI:2685628] ficolin A [Source:MGI Symbol;Acc:MGI:1340905] histamine N-methyltransferase [Source:MGI Symbol;Acc:MGI:2153181]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

purinergic receptor P2X, ligand-gated ion channel, 3 [Source:MGI Symbol;Acc:MGI:1097160] sialic acid binding Ig-like lectin 1, [Source:MGI Symbol;Acc:MGI:99668] solute carrier family 27 (fatty acid transporter), member 2 [Source:MGI Symbol;Acc:MGI:1347099] periostin, osteoblast specific factor [Source:MGI Symbol;Acc:MGI:1926321] WW domain containing transcription regulator 1 [Source:MGI Symbol;Acc:MGI:1917649] ventricular zone expressed PH domain-containing 1 [Source:MGI Symbol;Acc:MGI:1920039] vascular cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:98926] ATP-binding cassette, sub-family A (ABC1), member 4 [Source:MGI Symbol;Acc:MGI:109424] 3-hydroxyacyl-CoA dehydratase 4 [Source:MGI Symbol;Acc:MGI:1914025] major facilitator superfamily domain containing 2A [Source:MGI Symbol;Acc:MGI:1923824] T cell acute lymphocytic leukemia 1 [Source:MGI Symbol;Acc:MGI:98480] colony stimulating factor 3 receptor (granulocyte) [Source:MGI Symbol;Acc:MGI:1339755] FGR proto-oncogene, Src family tyrosine kinase [Source:MGI Symbol;Acc:MGI:95527] sphingomyelin phosphodiesterase, acid-like 3B [Source:MGI Symbol;Acc:MGI:1916022] prominin 1 [Source:MGI Symbol;Acc:MGI:1100886] protocadherin 7 [Source:MGI Symbol;Acc:MGI:1860487] cholinergic receptor, nicotinic, alpha polypeptide 9 [Source:MGI Symbol;Acc:MGI:1202403] major facilitator superfamily domain containing 7A [Source:MGI Symbol;Acc:MGI:2442629] 2'-5' oligoadenylate synthetase-like 2 [Source:MGI Symbol;Acc:MGI:1344390] serine dehydratase-like [Source:MGI Symbol;Acc:MGI:2182607] RAS protein activator like 1 (GAP1 like) [Source:MGI Symbol;Acc:MGI:1330842] 2 [Source:MGI Symbol;Acc:MGI:1354956] FK506 binding protein 9 [Source:MGI Symbol;Acc:MGI:1350921] SCO-spondin [Source:MGI Symbol;Acc:MGI:2674311] 9 (platelet) [Source:MGI Symbol;Acc:MGI:1860137] growth differentiation factor 3 [Source:MGI Symbol;Acc:MGI:95686] tubulin, alpha 8 [Source:MGI Symbol;Acc:MGI:1858225] C-type lectin domain family 4, member e [Source:MGI Symbol;Acc:MGI:1861232] C-type lectin domain family 4, member d [Source:MGI Symbol;Acc:MGI:1298389] C-type lectin domain family 4, member a2 [Source:MGI Symbol;Acc:MGI:1349412] C-type lectin domain family 1, member b [Source:MGI Symbol;Acc:MGI:1913287] epithelial 1 [Source:MGI Symbol;Acc:MGI:107941] domain containing 1 [Source:MGI Symbol;Acc:MGI:1914107] sodium channel, nonvoltage-gated 1 alpha [Source:MGI Symbol;Acc:MGI:101782] tumor necrosis factor receptor superfamily, member 1a [Source:MGI Symbol;Acc:MGI:1314884] CD9 antigen [Source:MGI Symbol;Acc:MGI:88348] leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 [Source:MGI Symbol;Acc:MGI , protein [Source:MGI Symbol;Acc:MGI:2661187] family 1A, phenol-preferring, member 1 [Source:MGI Symbol;Acc:MGI:102896] nuclear protein transcription regulator 1 [Source:MGI Symbol;Acc:MGI:1891834] [Source:MGI Symbol;Acc:MGI:96607] fibroblast growth factor 13 [Source:MGI Symbol;Acc:MGI:109178] calcium channel, voltage-dependent, alpha 1F subunit [Source:MGI Symbol;Acc:MGI:1859639] AF4/FMR2 family, member 2 [Source:MGI Symbol;Acc:MGI:1202294] NADPH oxidase 1 [Source:MGI Symbol;Acc:MGI:2450016] adhesion G protein-coupled receptor G2 [Source:MGI Symbol;Acc:MGI:2446854] biglycan [Source:MGI Symbol;Acc:MGI:88158] glucose-6-phosphate dehydrogenase X-linked [Source:MGI Symbol;Acc:MGI:105979] zinc finger, CCHC domain containing 18 [Source:MGI Symbol;Acc:MGI:1914245] coagulation [Source:MGI Symbol;Acc:MGI:103107] glutathione reductase [Source:MGI Symbol;Acc:MGI:95804]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

haptoglobin [Source:MGI Symbol;Acc:MGI:96211] dynein regulatory complex subunit 7 [Source:MGI Symbol;Acc:MGI:2685616] RIKEN cDNA 2310030G06 gene [Source:MGI Symbol;Acc:MGI:1914202] roundabout guidance receptor 3 [Source:MGI Symbol;Acc:MGI:1343102] low density lipoprotein receptor [Source:MGI Symbol;Acc:MGI:96765] RAB27A, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:1861441] aquaporin 9 [Source:MGI Symbol;Acc:MGI:1891066] phospholipid scramblase 1 [Source:MGI Symbol;Acc:MGI:893575] phospholipid scramblase 2 [Source:MGI Symbol;Acc:MGI:1270860] aph1 homolog B, gamma secretase subunit [Source:MGI Symbol;Acc:MGI:3522097] neutrophilic granule protein [Source:MGI Symbol;Acc:MGI:105983] lactotransferrin [Source:MGI Symbol;Acc:MGI:96837] cyclic AMP-regulated phosphoprotein, 21 [Source:MGI Symbol;Acc:MGI:107562] -like 2 [Source:MGI Symbol;Acc:MGI:1929286] beaded filament structural protein 2, phakinin [Source:MGI Symbol;Acc:MGI:1333828] 2'-5' oligoadenylate synthetase 3 [Source:MGI Symbol;Acc:MGI:2180850] KN motif and ankyrin repeat domains 1 [Source:MGI Symbol;Acc:MGI:2147707] alpha-kinase 2 [Source:MGI Symbol;Acc:MGI:2449492] UDP galactosyltransferase 8A [Source:MGI Symbol;Acc:MGI:109522] recombination activating gene 2 [Source:MGI Symbol;Acc:MGI:97849] adhesion G protein-coupled receptor E4 [Source:MGI Symbol;Acc:MGI:1196464] CaM kinase-like vesicle-associated [Source:MGI Symbol;Acc:MGI:2384296] C-type lectin domain family 1, member a [Source:MGI Symbol;Acc:MGI:2444151] tyrosine kinase with immunoglobulin-like and EGF-like domains 1 [Source:MGI Symbol;Acc:MGI:99906] predicted gene 5134 [Source:MGI Symbol;Acc:MGI:3646667] metastasis suppressor 1-like [Source:MGI Symbol;Acc:MGI:3039591] toll-like receptor 13 [Source:MGI Symbol;Acc:MGI:3045213] 2 [Source:MGI Symbol;Acc:MGI:1932093] homeobox 2 [Source:MGI Symbol;Acc:MGI:95668] CD300 molecule like family member d [Source:MGI Symbol;Acc:MGI:2442358] leucine rich repeat protein 1, neuronal [Source:MGI Symbol;Acc:MGI:106038] CD300A molecule [Source:MGI Symbol;Acc:MGI:2443411] [Source:MGI Symbol;Acc:MGI:96601] UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 [Source:MGI Symbol;Acc:MGI:1349403] family with sequence similarity 214, member A [Source:MGI Symbol;Acc:MGI:2387648] CCAAT/enhancer binding protein (C/EBP), alpha [Source:MGI Symbol;Acc:MGI:99480] immunoglobulin superfamily, member 6 [Source:MGI Symbol;Acc:MGI:1891393] forkhead box A1 [Source:MGI Symbol;Acc:MGI:1347472] transforming growth factor, beta induced [Source:MGI Symbol;Acc:MGI:99959] leucine-rich repeat kinase 2 [Source:MGI Symbol;Acc:MGI:1913975] leucine rich repeat protein 3, neuronal [Source:MGI Symbol;Acc:MGI:106036] histocompatibility 2, class II antigen E alpha, pseudogene [Source:MGI Symbol;Acc:MGI:95900] RIKEN cDNA C530008M17 gene [Source:MGI Symbol;Acc:MGI:2444817] membrane-associated ring finger (C3HC4) 1 [Source:MGI Symbol;Acc:MGI:1920175] gene regulated by estrogen in breast cancer protein [Source:MGI Symbol;Acc:MGI:2149712] MICAL-like 2 [Source:MGI Symbol;Acc:MGI:2444818] complement component 1, q subcomponent, alpha polypeptide [Source:MGI Symbol;Acc:MGI:88223] complement component 1, q subcomponent, C chain [Source:MGI Symbol;Acc:MGI:88225] leucine-rich alpha-2-glycoprotein 1 [Source:MGI Symbol;Acc:MGI:1924155] major facilitator superfamily domain containing 2B [Source:MGI Symbol;Acc:MGI:3583946] progestin and adipoQ receptor family member VII [Source:MGI Symbol;Acc:MGI:1919154]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

platelet-activating factor acetylhydrolase 2 [Source:MGI Symbol;Acc:MGI:2140321] zinc finger, matrin type 4 [Source:MGI Symbol;Acc:MGI:2443497] DAZ interacting protein 1-like [Source:MGI Symbol;Acc:MGI:1919757] transglutaminase 2, C polypeptide [Source:MGI Symbol;Acc:MGI:98731] ring finger protein 144B [Source:MGI Symbol;Acc:MGI:2384986] prolyl 3-hydroxylase 2 [Source:MGI Symbol;Acc:MGI:2146663] scavenger receptor class F, member 1 [Source:MGI Symbol;Acc:MGI:2449455] cathelicidin antimicrobial peptide [Source:MGI Symbol;Acc:MGI:108443] complement component 1, r subcomponent-like [Source:MGI Symbol;Acc:MGI:2660692] SH3 and multiple ankyrin repeat domains 1 [Source:MGI Symbol;Acc:MGI:3613677] glucosaminyl (N-acetyl) transferase 1, core 2 [Source:MGI Symbol;Acc:MGI:95676] ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 [S chondroadherin [Source:MGI Symbol;Acc:MGI:1096866] prune homolog 2 [Source:MGI Symbol;Acc:MGI:1925004] multiple EGF-like-domains 9 [Source:MGI Symbol;Acc:MGI:1918264] neural cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:97281] basic , ATF-like 2 [Source:MGI Symbol;Acc:MGI:1921731] TBC1 domain family, member 2 [Source:MGI Symbol;Acc:MGI:2652885] thrombospondin 1 [Source:MGI Symbol;Acc:MGI:98737] toll-like receptor 8 [Source:MGI Symbol;Acc:MGI:2176887] glutathione S-transferase, mu 2 [Source:MGI Symbol;Acc:MGI:95861] beta-site APP-cleaving enzyme 2 [Source:MGI Symbol;Acc:MGI:1860440] collagen, type XVI, alpha 1 [Source:MGI Symbol;Acc:MGI:1095396] inhibin beta-A [Source:MGI Symbol;Acc:MGI:96570] shootin 1 [Source:MGI Symbol;Acc:MGI:1918903] serine (or cysteine) peptidase inhibitor, clade A, member 3G [Source:MGI Symbol;Acc:MGI:105046] heat shock protein 8 [Source:MGI Symbol;Acc:MGI:2135756] CDC42 effector protein (Rho GTPase binding) 4 [Source:MGI Symbol;Acc:MGI:1929760] chondroitin sulfate N-acetylgalactosaminyltransferase 2 [Source:MGI Symbol;Acc:MGI:1926002] G protein-coupled receptor kinase 3 [Source:MGI Symbol;Acc:MGI:87941] solute carrier family 26, member 9 [Source:MGI Symbol;Acc:MGI:2444594] [Source:MGI Symbol;Acc:MGI:103022] arrestin domain containing 4 [Source:MGI Symbol;Acc:MGI:1913662] regulator of G-protein signaling 8 [Source:MGI Symbol;Acc:MGI:108408] transmembrane protein 108 [Source:MGI Symbol;Acc:MGI:1932411] MAM domain containing glycosylphosphatidylinositol anchor 1 [Source:MGI Symbol;Acc:MGI:1922012] 2-phosphoxylose phosphatase 1 [Source:MGI Symbol;Acc:MGI:2442444] RIKEN cDNA B430306N03 gene [Source:MGI Symbol;Acc:MGI:2443478] C-type lectin domain family 4, member a3 [Source:MGI Symbol;Acc:MGI:1920399] RIKEN cDNA A530064D06 gene [Source:MGI Symbol;Acc:MGI:2443476] chemokine (C-C motif) receptor 10 [Source:MGI Symbol;Acc:MGI:1096320] RIKEN cDNA C130050O18 gene [Source:MGI Symbol;Acc:MGI:2442694] dedicator of cytokinesis 5 [Source:MGI Symbol;Acc:MGI:2652871] CD300C molecule 2 [Source:MGI Symbol;Acc:MGI:2153249] formyl peptide receptor 1 [Source:MGI Symbol;Acc:MGI:107443] phosphotyrosine interaction domain containing 1 [Source:MGI Symbol;Acc:MGI:2138391] brain abundant, membrane attached signal protein 1 [Source:MGI Symbol;Acc:MGI:1917600] caveolae associated 2 [Source:MGI Symbol;Acc:MGI:99513] cholinergic receptor, muscarinic 3, cardiac [Source:MGI Symbol;Acc:MGI:88398] paired immunoglobin-like type 2 receptor alpha [Source:MGI Symbol;Acc:MGI:2450529] sodium channel, type IV, beta [Source:MGI Symbol;Acc:MGI:2687406]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

transmembrane protein 215 [Source:MGI Symbol;Acc:MGI:2444167] 3-hydroxybutyrate dehydrogenase, type 1 [Source:MGI Symbol;Acc:MGI:1919161] prostaglandin-endoperoxide synthase 1 [Source:MGI Symbol;Acc:MGI:97797] glycoprotein 5 (platelet) [Source:MGI Symbol;Acc:MGI:1096363] coagulation factor II () receptor [Source:MGI Symbol;Acc:MGI:101802] small integral membrane protein 5 [Source:MGI Symbol;Acc:MGI:1913778] CD300E molecule [Source:MGI Symbol;Acc:MGI:2387602] predicted gene 6377 [Source:MGI Symbol;Acc:MGI:3647255] C-type lectin domain family 4, member a1 [Source:MGI Symbol;Acc:MGI:3036291] angiotensin II receptor, type 1a [Source:MGI Symbol;Acc:MGI:87964] complement component 5a receptor 1 [Source:MGI Symbol;Acc:MGI:88232] zinc finger protein, multitype 1 [Source:MGI Symbol;Acc:MGI:1095400] glycosyltransferase 1 domain containing 1 [Source:MGI Symbol;Acc:MGI:2442755] leucine rich repeat containing 25 [Source:MGI Symbol;Acc:MGI:2445284] , regulatory subunit 3D [Source:MGI Symbol;Acc:MGI:1917664] zinc finger protein 697 [Source:MGI Symbol;Acc:MGI:2139736] coagulation factor II (thrombin) receptor-like 3 [Source:MGI Symbol;Acc:MGI:1298207] lectin, galactose binding, soluble 3 [Source:MGI Symbol;Acc:MGI:96778] lin-28 homolog A (C. elegans) [Source:MGI Symbol;Acc:MGI:1890546] olfactory receptor 523 [Source:MGI Symbol;Acc:MGI:3030357] tumor-associated calcium signal transducer 2 [Source:MGI Symbol;Acc:MGI:1861606] CD14 antigen [Source:MGI Symbol;Acc:MGI:88318] forkhead box D4 [Source:MGI Symbol;Acc:MGI:1347467] triggering receptor expressed on myeloid cells-like 4 [Source:MGI Symbol;Acc:MGI:1923239] WAP four-disulfide core domain 21 [Source:MGI Symbol;Acc:MGI:1913357] SRY (sex determining region Y)-box 6 [Source:MGI Symbol;Acc:MGI:98368] CD177 antigen [Source:MGI Symbol;Acc:MGI:1916141] formyl peptide receptor 2 [Source:MGI Symbol;Acc:MGI:1278319] monoacylglycerol O-acyltransferase 2 [Source:MGI Symbol;Acc:MGI:2663253] pre B cell leukemia homeobox 1 [Source:MGI Symbol;Acc:MGI:97495] copine VIII [Source:MGI Symbol;Acc:MGI:1914121] tripartite motif-containing 30B [Source:MGI Symbol;Acc:MGI:4821256] G protein-coupled receptor 141 [Source:MGI Symbol;Acc:MGI:2672983] aldehyde dehydrogenase family 1, subfamily A1 [Source:MGI Symbol;Acc:MGI:1353450] T cell-interacting, activating receptor on myeloid cells 1 [Source:MGI Symbol;Acc:MGI:2442280] hormonally upregulated Neu-associated kinase [Source:MGI Symbol;Acc:MGI:1347352] calcium/calmodulin-dependent protein kinase II, delta [Source:MGI Symbol;Acc:MGI:1341265] calponin 3, acidic [Source:MGI Symbol;Acc:MGI:1919244] multimerin 1 [Source:MGI Symbol;Acc:MGI:1918195] RIKEN cDNA 5830411N06 gene [Source:MGI Symbol;Acc:MGI:2443685] [Source:MGI Symbol;Acc:MGI:109611] leukocyte-associated Ig-like receptor 1 [Source:MGI Symbol;Acc:MGI:105492] T cell immunoglobulin and mucin domain containing 4 [Source:MGI Symbol;Acc:MGI:2445125] dachshund family transcription factor 1 [Source:MGI Symbol;Acc:MGI:1277991] chloride channel accessory 3A1 [Source:MGI Symbol;Acc:MGI:1316732] glutamate receptor, ionotropic, kainate 2 (beta 2) [Source:MGI Symbol;Acc:MGI:95815] platelet-activating factor receptor [Source:MGI Symbol;Acc:MGI:106066] FRY microtubule binding protein [Source:MGI Symbol;Acc:MGI:2443895] 1D [Source:MGI Symbol;Acc:MGI:2148202] early B cell factor 1 [Source:MGI Symbol;Acc:MGI:95275] killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 [Source:MGI Symbol;Acc:MGI:36

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

collagen-like tail subunit (single strand of homotrimer) of asymmetric [Source:MGI Symbol mab-21-like 2 (C. elegans) [Source:MGI Symbol;Acc:MGI:1346022] Nfat activating molecule with ITAM motif 1 [Source:MGI Symbol;Acc:MGI:1921289] deaminase [Source:MGI Symbol;Acc:MGI:95678] calpain 11 [Source:MGI Symbol;Acc:MGI:1352490] potassium channel, subfamily T, member 1 [Source:MGI Symbol;Acc:MGI:1924627] paired Ig-like receptor B [Source:MGI Symbol;Acc:MGI:894311] Fc receptor, IgG, low affinity IV [Source:MGI Symbol;Acc:MGI:2179523] interferon induced transmembrane protein 6 [Source:MGI Symbol;Acc:MGI:2686976] pre-B lymphocyte gene 2 [Source:MGI Symbol;Acc:MGI:98937] transmembrane protein 40 [Source:MGI Symbol;Acc:MGI:2137870] arachidonate 5-lipoxygenase activating protein [Source:MGI Symbol;Acc:MGI:107505] zinc finger protein 462 [Source:MGI Symbol;Acc:MGI:107690] carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 [Source:MGI Symbol;Acc:MGI:1916197] sterile alpha motif domain containing 5 [Source:MGI Symbol;Acc:MGI:2444815] mast cell protease 4 [Source:MGI Symbol;Acc:MGI:96940] , polypeptide 4 [Source:MGI Symbol;Acc:MGI:97267] B cell linker [Source:MGI Symbol;Acc:MGI:96878] recombination activating gene 1 [Source:MGI Symbol;Acc:MGI:97848] CTTNBP2 N-terminal like [Source:MGI Symbol;Acc:MGI:1933137] islet cell autoantigen 1 [Source:MGI Symbol;Acc:MGI:96391] diacylglycerol kinase, epsilon, opposite strand [Source:MGI Symbol;Acc:MGI:3041185] CD300 molecule like family member B [Source:MGI Symbol;Acc:MGI:2685099] G protein-coupled receptor 84 [Source:MGI Symbol;Acc:MGI:1934129] chitinase-like 1 [Source:MGI Symbol;Acc:MGI:1340899] paired immunoglobin-like type 2 receptor beta 1 [Source:MGI Symbol;Acc:MGI:2450532] 86 [Source:MGI Symbol;Acc:MGI:109362] C-type lectin domain family 4, member b2 [Source:MGI Symbol;Acc:MGI:3588267] transcription factor 15 [Source:MGI Symbol;Acc:MGI:104664] PHD finger protein 11D [Source:MGI Symbol;Acc:MGI:1277133] lysozyme 1 [Source:MGI Symbol;Acc:MGI:96902] lysozyme 2 [Source:MGI Symbol;Acc:MGI:96897] CD300 molecule like family member D3 [Source:MGI Symbol;Acc:MGI:2687214] cyclin D1 [Source:MGI Symbol;Acc:MGI:88313] family with sequence similarity 217, member B [Source:MGI Symbol;Acc:MGI:1918782] meningioma 1 [Source:MGI Symbol;Acc:MGI:1261813] selection and upkeep of intraepithelial T cells 3 [Source:MGI Symbol;Acc:MGI:3045331] leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 [Source:MGI Symbol;Acc:MGI NLR family, apoptosis inhibitory protein 5 [Source:MGI Symbol;Acc:MGI:1298220] CCAAT/enhancer binding protein (C/EBP), delta [Source:MGI Symbol;Acc:MGI:103573] colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) [Source:MGI Symbol;Acc:MGI predicted gene 10419 [Source:MGI Symbol;Acc:MGI:3642823] G protein-coupled receptor 27 [Source:MGI Symbol;Acc:MGI:1202299] acyl-CoA 1 [Source:MGI Symbol;Acc:MGI:1349396] GRAM domain containing 2 [Source:MGI Symbol;Acc:MGI:3528937] -related cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:1347245] RIKEN cDNA I830077J02 gene [Source:MGI Symbol;Acc:MGI:3588284] predicted gene 14548 [Source:MGI Symbol;Acc:MGI:3709645] potassium voltage-gated channel, subfamily G, member 1 [Source:MGI Symbol;Acc:MGI:3616086] plexin C1 [Source:MGI Symbol;Acc:MGI:1890127] homeobox B2 [Source:MGI Symbol;Acc:MGI:96183]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

immunoglobulin kappa chain variable 15-103 [Source:MGI Symbol;Acc:MGI:96513] immunoglobulin kappa variable 11-106 [Source:MGI Symbol;Acc:MGI:3648899] immunoglobulin kappa chain variable 4-70 [Source:MGI Symbol;Acc:MGI:2686348] immunoglobulin kappa chain variable 6-29 [Source:MGI Symbol;Acc:MGI:4439616] immunoglobulin heavy variable 7-2 [Source:MGI Symbol;Acc:MGI:4439623] immunoglobulin heavy variable 7-1 [Source:MGI Symbol;Acc:MGI:4439622] immunoglobulin heavy variable 3-5 [Source:MGI Symbol;Acc:MGI:3648045] immunoglobulin heavy variable 3-6 [Source:MGI Symbol;Acc:MGI:4439856] immunoglobulin heavy variable V1-18 [Source:MGI Symbol;Acc:MGI:4439780] RIKEN cDNA F630028O10 gene [Source:MGI Symbol;Acc:MGI:3641813] retinoic acid early transcript delta [Source:MGI Symbol;Acc:MGI:1861032] FYN binding protein 2 [Source:MGI Symbol;Acc:MGI:2685466] ecotropic viral integration site 2a [Source:MGI Symbol;Acc:MGI:95458] binding protein 1-like 1 [Source:MGI Symbol;Acc:MGI:1913505] family with sequence similarity 155, member A [Source:MGI Symbol;Acc:MGI:2142765] toll-like receptor 5 [Source:MGI Symbol;Acc:MGI:1858171] NHS-like 2 [Source:MGI Symbol;Acc:MGI:3645090] histocompatibility 2, class II, Mb1 [Source:MGI Symbol;Acc:MGI:95922] predicted gene 595 [Source:MGI Symbol;Acc:MGI:2685441] predicted gene 15925 [Source:MGI Symbol;Acc:MGI:3801830] predicted gene 15922 [Source:MGI Symbol;Acc:MGI:3802148] predicted gene 15931 [Source:MGI Symbol;Acc:MGI:3805553] predicted gene 15987 [Source:MGI Symbol;Acc:MGI:3801849] tumor necrosis factor (ligand) superfamily, member 13, opposite strand [Source:MGI Symbol;Acc:MGI:1919587] predicted gene 14317 [Source:MGI Symbol;Acc:MGI:3651690] RIKEN cDNA 5830418P13 gene [Source:MGI Symbol;Acc:MGI:3604110] predicted gene 13431 [Source:MGI Symbol;Acc:MGI:3650776] paired-Ig-like receptor A2 [Source:MGI Symbol;Acc:MGI:1195970] predicted gene 15657 [Source:MGI Symbol;Acc:MGI:3783100] SEC14-like lipid binding 5 [Source:MGI Symbol;Acc:MGI:3616084] serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10 [Source:MGI Symbol;Acc:MGI:2138648 immunoglobulin heavy diversity 4-1 [Source:MGI Symbol;Acc:MGI:4439801] immunoglobulin heavy variable 2-3 [Source:MGI Symbol;Acc:MGI:4439872] predicted gene 5294 [Source:MGI Symbol;Acc:MGI:3646467] immunoglobulin heavy variable 1-84 [Source:MGI Symbol;Acc:MGI:3644235] inositol 1,4,5-triphosphate receptor interacting protein-like 2 [Source:MGI Symbol;Acc:MGI:2442416] midline 1, pseudogene 1 [Source:MGI Symbol;Acc:MGI:5780070] immunoglobulin heavy variable V1-59 [Source:MGI Symbol;Acc:MGI:3644474] immunoglobulin heavy variable 1-52 [Source:MGI Symbol;Acc:MGI:4439752] immunoglobulin heavy variable 1-66 [Source:MGI Symbol;Acc:MGI:4439825] predicted gene, 21188 [Source:MGI Symbol;Acc:MGI:5434543] immunoglobulin kappa variable 4-58 [Source:MGI Symbol;Acc:MGI:2685923] signal-regulatory protein beta 1A [Source:MGI Symbol;Acc:MGI:2444824] immunoglobulin heavy variable V8-4 [Source:MGI Symbol;Acc:MGI:3646040] immunoglobulin kappa variable 10-94 [Source:MGI Symbol;Acc:MGI:3646140] immunoglobulin heavy variable 2-5 [Source:MGI Symbol;Acc:MGI:4439517] immunoglobulin heavy variable 2-7 [Source:MGI Symbol;Acc:MGI:4439521] RIKEN cDNA B230208H11 gene [Source:MGI Symbol;Acc:MGI:2443719] RIKEN cDNA 9530026P05 gene [Source:MGI Symbol;Acc:MGI:1924659] RIKEN cDNA E230029C05 gene [Source:MGI Symbol;Acc:MGI:2442580] cDNA sequence BC051537 [Source:MGI Symbol;Acc:MGI:3041255]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

predicted gene 5833 [Source:MGI Symbol;Acc:MGI:3779530] membrane-spanning 4-domains, subfamily A, member 4A [Source:MGI Symbol;Acc:MGI:3643932] predicted gene, 19331 [Source:MGI Symbol;Acc:MGI:5011516] immunoglobulin heavy variable 1-2 [Source:MGI Symbol;Acc:MGI:4439924] immunoglobulin heavy variable 5-12-4 [Source:MGI Symbol;Acc:MGI:3645977] predicted gene, 30948 [Source:MGI Symbol;Acc:MGI:5590107] immunoglobulin heavy variable V1-27 [Source:MGI Symbol;Acc:MGI:5009908] RIKEN cDNA 5830405F06 gene [Source:MGI Symbol;Acc:MGI:1923265] predicted gene 4610 [Source:MGI Symbol;Acc:MGI:3782793] immunoglobulin kappa chain variable [Source:MGI Symbol;Acc:MGI:5009877] RIKEN cDNA 4930519L02 gene [Source:MGI Symbol;Acc:MGI:1922335] predicted gene 42517 [Source:MGI Symbol;Acc:MGI:5662654] immunoglobulin heavy variable 1-70 [Source:MGI Symbol;Acc:MGI:3644620] predicted gene, 19719 [Source:MGI Symbol;Acc:MGI:5011904] predicted gene, 43904 [Source:MGI Symbol;Acc:MGI:5690296] predicted gene 44860 [Source:MGI Symbol;Acc:MGI:5753436] leukocyte immunoglobulin-like receptor, subfamily B, member 4B [Source:MGI Symbol;Acc:MGI:102702] leukocyte immunoglobulin-like receptor, subfamily B, member 4A [Source:MGI Symbol;Acc:MGI:102701] expressed sequence AU015791 [Source:MGI Symbol;Acc:MGI:2144938] predicted gene, 36161 [Source:MGI Symbol;Acc:MGI:5595320] predicted gene, 31583 [Source:MGI Symbol;Acc:MGI:5590742] predicted gene, 35853 [Source:MGI Symbol;Acc:MGI:5595012] novel transcript

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

logFC logCPM LR PValue FDR 3.477124686 4.53052177 13.20697899 0.000278909 0.02097647 3.168927049 5.253735275 11.79921894 0.000592556 0.032111652 -0.819518851 5.642127807 11.321193 0.000766275 0.037703763 1.573487925 1.309654615 13.23811192 0.000274314 0.020789013 -1.753126084 3.637339564 22.93147351 1.6788E-06 0.000562826 1.897485633 4.625007556 10.48465067 0.001203704 0.049822769 2.676688796 0.172418055 17.54594118 2.80449E-05 0.004584526 1.812827468 2.158265508 13.51037372 0.000237248 0.018696299 0.919134691 7.209508137 12.4303134 0.000422421 0.027128206 1.184987008 3.319906197 12.08494079 0.000508307 0.029571516 2.115262403 5.462684049 33.34708772 7.70932E-09 1.5249E-05 1.123582587 4.886936344 11.95522136 0.000544945 0.030671316 1.276826423 2.76831305 10.57476854 0.001146416 0.048635284 1.396535599 6.386438162 24.62411021 6.96745E-07 0.000328134 1.023816836 5.689982967 11.91085216 0.000558079 0.03102355 0.786906671 6.833343088 11.47504435 0.00070537 0.03550181 2.482937824 4.157214352 13.9753531 0.000185223 0.01623077 2.726837769 3.019287692 11.17179019 0.000830505 0.039584047 1.199059673 5.194421823 12.52979803 0.000400513 0.026247867 2.954572411 3.661578461 11.64878762 0.000642444 0.033707004 3.032648819 1.90738796 17.60283554 2.72182E-05 0.004562512 2.593294647 2.921216543 10.91072961 0.000956089 0.043776465 1.220515809 6.051850408 20.83650435 5.00204E-06 0.001355348 2.156695387 -0.504951759 13.61134034 0.000224823 0.017859459 -1.775649984 3.330966763 16.21846863 5.64412E-05 0.007393421 1.286314694 4.204864858 12.15645651 0.000489182 0.029019095 3.359872258 5.754626023 12.7112526 0.000363462 0.025049743 1.512685855 3.999327534 16.02239016 6.25978E-05 0.007848349 1.796110761 -0.595539434 10.92879907 0.000946808 0.043553191 2.057927945 -0.010483466 11.65305732 0.000640971 0.033707004 1.294254654 3.927109513 12.22683121 0.000471071 0.028150428 1.055050011 4.571490804 10.59889971 0.00113155 0.048551095 1.63278861 3.970825951 12.61161417 0.000383357 0.025879889 2.714128712 4.057372068 16.01955628 6.26916E-05 0.007848349 1.488788661 3.869820511 13.47133874 0.000242235 0.018863844 1.25705348 5.587645757 16.07079228 6.10179E-05 0.007786675 2.229023628 1.061297044 11.17230612 0.000830274 0.039584047 2.632008718 0.366752837 20.28560038 6.67007E-06 0.001713428 1.308799967 1.803422814 10.79672802 0.001016797 0.04553747 1.923435976 0.095474893 12.56812513 0.000392382 0.026247867 1.562335037 7.243611572 24.73265898 6.58587E-07 0.000328134 1.456135829 3.996956602 13.84050355 0.000199 0.016893638 1.326960296 5.406011324 12.88579319 0.000331086 0.023642155 3.346444431 0.841275564 35.41055072 2.67036E-09 7.54569E-06 1.326167441 5.722052684 15.87886516 6.75286E-05 0.008296375 2.310303828 0.083563711 16.7566209 4.24937E-05 0.006003756 1.302684472 6.915608077 10.94315889 0.000939499 0.043317672

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1.658976168 4.959679729 35.08906586 3.14964E-09 7.54763E-06 -1.083581568 7.477346723 11.14461219 0.000842761 0.039975565 1.893712321 -0.166075683 12.29521296 0.000454122 0.027701217 3.175791305 6.42192771 11.6554555 0.000640145 0.033707004 2.096750182 1.066959591 12.07920082 0.000509874 0.029575711 1.046737955 4.905114711 16.37581979 5.19437E-05 0.006989428 1.463405791 3.66322374 11.72685849 0.000616045 0.033112417 2.109180262 2.713319973 20.22718201 6.87688E-06 0.001743907 1.684659523 1.232380957 11.42487254 0.000724674 0.036105922 -1.498804323 4.785703418 17.48020489 2.90315E-05 0.004706907 1.290445644 2.192333354 10.73964395 0.001048645 0.046146989 1.11371212 5.064866826 13.29066905 0.00026673 0.020370367 1.314942519 4.876746656 25.8951295 3.60478E-07 0.00022282 -3.786277388 -1.42910672 23.18027799 1.47502E-06 0.000530472 1.454813894 2.505476595 13.91605326 0.000191159 0.016439658 2.27413243 2.051842889 16.80514496 4.14208E-05 0.005980324 4.531804211 2.424721452 21.163867 4.21639E-06 0.001191432 1.263310899 5.48578313 18.17940807 2.01041E-05 0.003648245 1.952017445 -0.33483516 12.21517408 0.000474024 0.028241543 1.641460093 4.979232593 24.92803442 5.95107E-07 0.000318141 2.523374971 1.884532004 25.91569214 3.56658E-07 0.00022282 1.063320069 5.092766826 15.79176099 7.07098E-05 0.008511548 2.148257272 4.477118979 11.09014491 0.000867877 0.04077579 1.883488691 1.47647827 12.37934646 0.000434109 0.027244711 -1.946397124 -0.412631797 11.6877595 0.000629126 0.03345192 1.088589167 3.048886046 10.53184514 0.00117335 0.048860767 1.879673232 6.316816332 25.16481238 5.26338E-07 0.000289194 3.256100331 0.003104097 13.19077428 0.000281331 0.021078485 -1.523428746 3.707790625 15.5500309 8.03503E-05 0.009348998 2.367313261 0.529755257 15.02058358 0.000106345 0.011432079 1.194683591 5.74053055 13.0718545 0.000299766 0.021799174 0.927195934 4.713822136 11.94694771 0.00054737 0.030671316 1.068258442 5.241383132 19.40684341 1.05628E-05 0.002401517 1.936385191 0.977126365 12.14919116 0.000491092 0.029019095 2.144405176 3.194545125 33.03737774 9.04041E-09 1.62563E-05 -2.223378869 3.341713141 15.82045058 6.96457E-05 0.008451481 3.643401002 4.360449487 14.44095424 0.000144623 0.014225239 1.987602989 2.724908892 14.5393733 0.000137261 0.013994927 -2.176104533 3.4125637 11.04475383 0.000889385 0.041588741 3.245187154 -1.776576775 14.25874663 0.000159319 0.015223785 1.306450639 2.77244654 10.89714841 0.000963124 0.043996757 3.935445682 -0.925095656 13.7334993 0.000210663 0.017077544 2.426290175 -0.497665751 14.99123811 0.000108012 0.011548475 -1.463443453 3.49199821 16.20059021 5.69764E-05 0.007414424 1.270416475 4.020791522 12.32471931 0.000446999 0.027593046 3.441096823 1.178956194 14.73503581 0.000123726 0.012880488 1.231696467 6.361947971 23.01722927 1.60556E-06 0.00054776 1.302722072 4.760003703 15.70794847 7.39129E-05 0.008807214 3.981569895 -0.85487558 19.47090289 1.02144E-05 0.002376948 1.996391044 7.168800857 27.90512944 1.27412E-07 0.000114555 -1.176706138 6.529776602 18.62324536 1.59267E-05 0.003119104

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1.509362478 5.419236731 21.40784802 3.71248E-06 0.001096014 1.233080257 3.574854869 14.22286307 0.000162386 0.015262028 1.445499087 3.954758969 14.12150038 0.000171374 0.015549417 1.015977351 5.226610096 13.80127555 0.000203198 0.016934578 2.645862001 -1.265470314 10.73040287 0.001053895 0.046146989 2.645843872 1.692204168 10.79736092 0.001016449 0.04553747 2.47956191 -1.913210101 15.89776092 6.68578E-05 0.008265291 3.189246316 2.22515396 10.99198606 0.000915067 0.042388818 1.04218107 4.517082042 14.00564101 0.000182263 0.016094474 2.59874169 3.671841975 11.02466949 0.000899073 0.041843919 1.880372827 5.196154363 54.41805116 1.62067E-13 3.20569E-09 2.821199357 6.164332473 13.73510644 0.000210483 0.017077544 2.601570456 0.764924743 14.09469356 0.000173833 0.015586524 1.823365113 5.404325372 13.78034077 0.000205475 0.016934578 2.78317769 7.144597569 24.66140456 6.83391E-07 0.000328134 2.767423906 -0.187903727 19.68396464 9.13648E-06 0.002231106 3.301064426 -0.978943437 16.771002 4.21729E-05 0.006001291 2.978227348 1.61492465 10.55607648 0.001158067 0.048635284 -1.738467019 9.33982808 11.26958994 0.000787871 0.038479246 3.742656463 -0.399747632 18.2501098 1.93715E-05 0.00354785 -2.591784068 3.699214406 26.9452924 2.09296E-07 0.000153329 1.379619024 6.91125913 36.13639227 1.83979E-09 6.06516E-06 1.837315966 4.091447908 12.66848042 0.000371872 0.025364211 2.166351745 0.950925803 18.62550723 1.59078E-05 0.003119104 -1.386448669 3.598792153 15.78397653 7.10013E-05 0.008511548 1.283792018 6.435130459 17.21714838 3.33413E-05 0.005155607 1.258677079 6.020391865 17.07942097 3.58487E-05 0.005371867 1.311592239 3.69062673 11.80383802 0.000591087 0.032111652 1.554760553 3.125000629 10.95954271 0.000931228 0.043036656 2.997324274 2.870915649 11.46780796 0.000708122 0.035549859 1.432659084 6.574667608 14.33804085 0.000152747 0.014810458 1.278341793 4.399643635 16.14754303 5.85945E-05 0.007575162 -1.627337159 3.93979109 16.50421697 4.8542E-05 0.006621797 3.035458913 2.512918816 10.87946385 0.000972364 0.044316493 2.737016073 4.008784562 10.7953179 0.001017571 0.04553747 3.860583012 5.101051472 38.54288655 5.35636E-10 2.64872E-06 2.548188707 1.143698206 17.17770683 3.40408E-05 0.005155607 2.081589389 1.490496072 13.45711811 0.000244078 0.018932825 1.871937668 1.771065487 19.72176369 8.95754E-06 0.002214752 0.801504779 6.330871645 12.02998651 0.000523515 0.030014834 2.300280801 0.399732069 10.74246921 0.001047045 0.046146989 -3.106491416 -1.544990368 13.27131397 0.000269498 0.020502598 2.548456994 0.304594204 12.38243717 0.000433391 0.027244711 2.815995175 3.927378341 28.02015065 1.20059E-07 0.000113084 2.790991619 4.402987427 34.92063967 3.43421E-09 7.54763E-06 3.356993155 7.744586097 13.11249145 0.000293333 0.021545247 2.908589508 4.628206979 11.52813187 0.000685509 0.034784308 0.835338573 5.077172619 11.74972138 0.000608523 0.032797259 1.499548462 4.743603126 13.92307819 0.000190446 0.016439658 2.109735968 0.318112167 12.27383699 0.000459353 0.027701217 1.32760817 3.096871417 10.72930282 0.001054522 0.046146989

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

-1.417822175 1.368991508 10.5489789 0.001162523 0.048635284 2.838385041 0.534084173 16.99047801 3.75678E-05 0.005587144 -2.075282993 1.710157893 15.67683508 7.51388E-05 0.008862695 -1.54005678 2.785622408 19.47318746 1.02022E-05 0.002376948 2.524365867 1.917981438 25.37445349 4.72129E-07 0.00026682 2.535169494 0.237425487 16.02768446 6.2423E-05 0.007848349 2.11843399 3.165086318 12.45940556 0.000415892 0.026883494 2.153268121 3.088593648 24.45242518 7.61676E-07 0.000340125 1.129637446 5.208135416 18.62486287 1.59132E-05 0.003119104 -1.919266917 -0.096747078 12.132027 0.000495632 0.029105483 0.852547998 6.620552098 11.01225456 0.000905115 0.042026226 1.169377867 7.454795172 13.47156368 0.000242206 0.018863844 1.767990972 4.909190655 10.57317015 0.001147408 0.048635284 3.421667235 0.012428559 28.11323535 1.14421E-07 0.000113084 2.678719872 2.507246291 12.05768608 0.000515793 0.029814817 1.47435322 3.373729227 10.74881605 0.001043461 0.046146989 -2.42918575 -1.358459711 13.58636124 0.000227835 0.018026293 1.39170715 1.496473026 10.78084927 0.001025556 0.045688065 1.010065111 5.612775373 16.52225753 4.80823E-05 0.006604642 1.607512545 4.944699976 22.56486673 2.03166E-06 0.000641345 -1.373081785 4.67825716 23.01649687 1.60617E-06 0.00054776 1.089861337 6.31976018 18.78402104 1.46388E-05 0.003047962 1.187130587 4.805376258 11.47677765 0.000704712 0.03550181 -1.997602724 4.617884779 16.84589463 4.05409E-05 0.005906242 1.505669576 2.980826153 12.38399625 0.000433029 0.027244711 1.60550859 2.538549849 15.12875664 0.000100422 0.011096901 1.245424826 2.868849549 11.71769789 0.000619085 0.033185636 2.471120219 3.986213995 37.36749912 9.78391E-10 3.87051E-06 2.305464658 2.57330346 12.82552 0.000341923 0.023983142 3.369608053 3.30895284 14.09273208 0.000174015 0.015586524 2.098350642 0.121239009 13.89764927 0.00019304 0.016458303 -1.559516424 5.983576812 20.35496516 6.4326E-06 0.001674168 2.606534132 4.879320532 14.36684566 0.000150428 0.014657444 1.743885706 2.063640276 11.5448939 0.000679356 0.034784308 0.749756903 6.468013243 12.12210614 0.000498276 0.029159463 1.192515439 5.174081773 23.07470916 1.55827E-06 0.00054776 2.722342495 2.092224837 12.8422665 0.000338877 0.023854039 1.753302355 0.050048323 11.85547376 0.000574921 0.031588719 1.864557737 3.791526149 24.67081646 6.80062E-07 0.000328134 1.643818743 2.923840251 15.40179328 8.69058E-05 0.009936395 2.218801985 4.662144333 16.5534615 4.72976E-05 0.006591206 -1.659690782 1.723855793 12.54183623 0.000397941 0.026247867 2.355039791 -1.606158813 10.57060409 0.001149002 0.048635284 4.185829953 -0.770918723 16.84270398 4.06091E-05 0.005906242 -2.048732371 3.978887845 23.91542378 1.00662E-06 0.000417287 2.213188133 1.17812418 17.79196869 2.46421E-05 0.004238445 1.100409049 4.07419473 11.62646096 0.000650201 0.033844699 0.865914766 5.975968602 12.05328743 0.000517011 0.029814817 -1.084702425 4.163470862 11.24287754 0.000799291 0.038695609 2.776973341 2.553726638 14.12471686 0.000171081 0.015549417 1.565158973 6.311629507 16.53139077 4.78513E-05 0.006604642

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

2.908964634 5.79386954 12.4014757 0.000428995 0.027244711 -1.684454193 4.868269669 22.55445033 2.04271E-06 0.000641345 4.188063871 -1.933335492 15.35284714 8.91864E-05 0.010138549 1.719239758 3.036756935 21.71326137 3.16595E-06 0.000948826 -0.993786891 5.452097804 15.30989046 9.12376E-05 0.010195927 0.820058401 6.33090395 14.18987756 0.000165257 0.015418802 0.940587848 4.414118826 11.63057192 0.000648766 0.033844699 0.857433578 4.844261666 13.08717786 0.000297324 0.021701357 2.467467479 2.081939881 22.41248889 2.19939E-06 0.000669292 1.291456088 2.848778465 14.14238221 0.000169482 0.015549417 3.436065434 9.471346755 11.86574648 0.000571758 0.031502459 3.297115696 8.911990558 10.84018526 0.000993208 0.045162421 -1.882662045 5.232335174 20.60869687 5.63396E-06 0.001505942 2.268310209 2.850632541 27.45122857 1.61106E-07 0.000134409 -1.525619755 3.034581959 14.21800532 0.000162805 0.015262028 1.099239075 5.059374596 17.19661806 3.37036E-05 0.005155607 2.035857999 -0.4914522 10.62680438 0.001114602 0.048032286 -1.471135434 2.308475527 11.10591861 0.000860527 0.040623426 1.916981961 1.586026385 14.16689739 0.000167288 0.015462403 -1.687860318 3.237977429 12.13108691 0.000495882 0.029105483 3.389440065 2.354587411 27.00738103 2.0268E-07 0.000153329 -1.610457074 3.367851135 13.79442472 0.000203941 0.016934578 2.157372022 2.837754829 23.20539147 1.45589E-06 0.000530472 0.973172889 6.649195966 12.11222545 0.000500923 0.029227906 -1.313852238 2.875647012 11.5829146 0.000665605 0.034465115 1.237520252 4.701771621 16.55264007 4.73181E-05 0.006591206 3.172053698 2.47985761 14.96549483 0.000109495 0.011644165 1.115814826 4.979238635 11.53539943 0.000682834 0.034784308 1.895860008 1.188176836 14.51123007 0.000139326 0.014094021 5.044502485 1.443178712 19.61422109 9.47612E-06 0.002258286 2.620463115 -1.233487497 14.61178709 0.000132086 0.013607589 1.557349851 4.586202886 26.45152696 2.70235E-07 0.000184319 1.982594863 6.382934533 48.63324117 3.08594E-12 3.052E-08 2.678638309 0.261247145 13.90724806 0.000192056 0.01644535 -1.262040743 7.282073195 12.69125012 0.000367371 0.02514391 1.75059853 5.730926198 41.99923296 9.13092E-11 6.02032E-07 2.215365016 4.717862486 10.54819248 0.001163018 0.048635284 -3.773364325 -0.947911022 16.4488935 4.99793E-05 0.006771174 2.361463993 4.63236215 32.60775612 1.12764E-08 1.85872E-05 1.835874785 4.864068089 18.43757771 1.75562E-05 0.003317614 -1.427567802 4.35986638 13.22687747 0.000275963 0.020834165 1.171311211 4.316507118 17.56105407 2.78229E-05 0.004584526 1.253025304 4.423084763 14.43250694 0.000145273 0.014225239 2.596348302 2.397600603 17.18139997 3.39747E-05 0.005155607 3.257601653 -0.049239941 17.58525139 2.74711E-05 0.004566199 1.022510784 4.679672623 13.61815852 0.000224008 0.017859459 2.210458484 1.344159578 15.0338555 0.0001056 0.011432079 2.467162841 1.300318837 17.17190994 3.41448E-05 0.005155607 3.12440699 3.903315649 10.76522833 0.001034248 0.045971745 0.949972811 4.933202374 12.5117118 0.000404409 0.026400027 0.899442043 4.914758027 12.52939525 0.000400599 0.026247867

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0.84247289 5.864136978 12.86837895 0.000334181 0.023697945 2.234469841 -1.887159713 11.24586843 0.000798004 0.038695609 2.888229994 -1.049912038 11.70098815 0.000624669 0.033394476 1.782973864 6.180191717 31.67595125 1.82164E-08 2.57372E-05 1.216043458 3.693539686 14.00644154 0.000182185 0.016094474 2.015830411 0.529468261 18.03871412 2.16458E-05 0.003822803 1.169092585 5.397349643 14.26491133 0.000158798 0.015223785 3.384114896 7.9863097 12.29075812 0.000455207 0.027701217 1.605617488 3.284859743 23.31677189 1.37397E-06 0.000530472 -1.381369981 2.720466057 11.22197118 0.000808346 0.038997761 0.812594242 5.513856466 12.39330168 0.000430877 0.027244711 1.81867163 2.367742645 23.80691606 1.06499E-06 0.000429909 1.584646129 2.067714325 12.53062829 0.000400335 0.026247867 1.857147639 1.342988746 13.62239874 0.000223503 0.017859459 1.502995412 4.873772769 12.80565523 0.000345573 0.024137117 2.245963292 2.152966961 12.47859417 0.000411642 0.026783803 1.609624416 1.675638206 12.46638353 0.000414342 0.026871066 0.909836947 4.441731874 11.4574756 0.00071207 0.035657563 2.221635796 6.666225351 19.05317073 1.27126E-05 0.002763252 3.449678561 1.02504495 19.11440846 1.23112E-05 0.002736128 2.233020207 0.392957443 14.64424125 0.000129831 0.013445297 2.914560321 1.553595697 23.27321118 1.40544E-06 0.000530472 1.140404953 5.211243454 16.2224355 5.63231E-05 0.007393421 2.59646044 2.336989741 11.94860679 0.000546883 0.030671316 1.38203823 2.523393805 14.47255149 0.000142217 0.01420732 0.983637193 7.132897235 10.50316157 0.001191705 0.049520837 1.649568027 0.620489421 10.48418334 0.001204008 0.049822769 1.059790771 3.720700053 12.01445301 0.000527896 0.030178551 0.88255393 6.058912187 11.82835949 0.000583354 0.031827805 0.850762777 6.217134478 10.92311911 0.000949716 0.043585563 -3.141745939 -0.270415796 11.95188884 0.00054592 0.030671316 -1.8110808 4.475581537 15.19789641 9.68112E-05 0.010758009 1.380753297 4.500243865 25.52732096 4.36163E-07 0.000261433 -1.805545652 2.67874328 11.09619134 0.000865052 0.040739827 -1.808060809 2.782861011 18.70364107 1.52691E-05 0.003090252 0.946537361 6.573445577 15.40904017 8.65731E-05 0.009936395 0.830507734 5.094929908 11.43232839 0.000721772 0.036052137 2.157001563 3.627549744 11.54639976 0.000678806 0.034784308 4.129027479 1.285520106 28.96679754 7.36296E-08 8.09107E-05 2.984873443 1.939310264 13.33638701 0.000260305 0.0200344 -2.464206614 1.610703094 22.45455349 2.15175E-06 0.000665025 1.698632501 1.378914765 13.17347848 0.000283939 0.021193649 0.996576453 5.608058749 15.07974975 0.000103063 0.011262906 3.019514842 1.225980354 17.96523577 2.24976E-05 0.003903538 3.107983469 2.131896925 11.69283844 0.000627411 0.033450653 2.22765681 1.154695053 14.58768822 0.000133786 0.013711309 -1.011881048 5.549725009 15.67341912 7.52747E-05 0.008862695 2.433043042 3.720302351 29.50341087 5.58184E-08 6.90055E-05 2.223010405 0.776679369 15.0852629 0.000102762 0.011262906 3.189596789 2.584948472 11.9160151 0.000556534 0.03102355 -2.203261059 2.026023757 11.8949165 0.000562874 0.031186661

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-2.487320348 11.07187921 11.35781672 0.000751311 0.037245438 -4.124223222 -1.295581568 12.54168649 0.000397973 0.026247867 -2.978105304 6.978149154 19.01898988 1.29424E-05 0.002782616 -3.562427743 -1.467351639 22.65825566 1.93527E-06 0.000627535 -1.852123649 -1.603237379 10.54911528 0.001162437 0.048635284 -3.067773886 10.53744557 25.41461516 4.62402E-07 0.00026682 -4.312368834 1.958243334 13.10823172 0.000294001 0.021545247 -3.182828037 3.485029831 12.6365452 0.000378278 0.025624476 -2.395955347 5.221613485 24.42201815 7.73793E-07 0.000340125 2.029179973 3.497645046 10.7153794 0.001062487 0.046392907 -2.413903858 -1.20566034 14.49717119 0.00014037 0.014094021 2.834240028 2.977020912 15.8571914 6.83065E-05 0.008340135 -1.030232804 4.735320945 11.9099094 0.000558361 0.03102355 2.190056579 -1.288711114 10.62860953 0.001113514 0.048032286 -4.260975333 -2.096762809 17.2165424 3.3352E-05 0.005155607 2.372487141 0.24667814 13.79683163 0.000203679 0.016934578 2.179922942 4.271953856 16.12243181 5.93766E-05 0.007626419 1.205115302 3.921896574 11.67106344 0.000634797 0.033662969 -3.928330616 -1.696889864 17.32724756 3.14643E-05 0.004978908 3.336330298 -2.368491533 12.56616767 0.000392793 0.026247867 2.607837955 -0.174117526 14.87084395 0.000115129 0.01217779 2.551854914 -0.12025061 14.80295656 0.000119348 0.012556959 2.13369948 0.564226626 11.83004104 0.000582827 0.031827805 1.665581909 1.12699323 12.30792541 0.000451039 0.027701217 2.357156774 -1.3237853 11.16341503 0.000834262 0.039667559 -1.471302145 3.044820934 20.50314079 5.95335E-06 0.001570096 2.301276275 0.613966748 17.62695166 2.68753E-05 0.004562512 3.085765813 -0.630326185 13.13854555 0.000289282 0.021511295 1.705225749 2.338704252 13.3225267 0.000262237 0.020104804 -2.15789372 1.791395456 12.23068883 0.000470098 0.028150428 3.029197912 1.926128215 18.70748804 1.52383E-05 0.003090252 -1.794149209 -0.315006349 11.82597963 0.0005841 0.031827805 -3.254500034 6.427534548 10.76060416 0.001036835 0.045983414 2.866811072 -2.1150859 10.54174177 0.001167084 0.048702359 -2.595178057 6.657187892 12.14773149 0.000491476 0.029019095 1.265857682 4.787065528 18.12178838 2.07217E-05 0.003726133 -1.9233371 -0.194115837 10.57450771 0.001146578 0.048635284 -6.225317481 5.036809026 19.29907768 1.1176E-05 0.002512067 -2.278855714 4.223305684 31.78079514 1.72591E-08 2.57372E-05 -2.863778685 4.551965152 11.6643919 0.000637078 0.033693571 2.972989429 0.259097461 11.74985615 0.000608479 0.032797259 -4.389059681 5.107541531 11.28733833 0.000780375 0.03820746 3.992309487 -0.668912254 12.38511247 0.000432771 0.027244711 -5.868552974 -0.93959456 15.31964775 9.07675E-05 0.010195927 -1.960174383 6.49738524 11.26454344 0.000790016 0.038488961 -3.578259792 5.39380722 11.13604677 0.000846661 0.040064503 -3.223358475 4.44720699 27.2789858 1.76115E-07 0.000139342 2.148818719 1.829769582 12.35154368 0.000440622 0.027407242 2.152363489 -1.0503824 10.78164714 0.001025114 0.045688065 1.793318892 -0.430549815 10.73704182 0.001050121 0.046146989 1.696048381 2.243120425 14.7687431 0.000121533 0.01271921

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

2.619243265 0.483504119 16.77939971 4.19866E-05 0.006001291 4.217224536 -0.260288153 24.47452751 7.52988E-07 0.000340125 -1.925596626 0.540131934 11.19927459 0.000818293 0.039381602 -2.52704207 0.667944675 18.31502351 1.87225E-05 0.003461035 -2.453150135 2.324470351 13.76690359 0.00020695 0.01698537 -2.052902746 1.832658055 10.69626228 0.001073522 0.04677151 -1.816488898 0.65291258 11.24093913 0.000800127 0.038695609 -2.159546617 -0.545012006 12.36520629 0.000437409 0.027293232 -1.987850721 0.718676862 11.19436981 0.000820459 0.039389996 -6.444861224 0.649661992 24.21523782 8.6148E-07 0.000370436 1.368916009 3.254580318 11.97031968 0.000540547 0.030671316 2.319793773 2.4878761 27.42762704 1.63085E-07 0.000134409 -2.39427937 7.861590004 10.81817256 0.001005086 0.045493387 1.536104161 1.743979986 12.32140249 0.000447794 0.027593046 2.48425963 -0.185506237 18.01395885 2.19291E-05 0.003838564 3.839461819 -2.601981409 12.90448786 0.000327795 0.02349199 2.317575325 5.013340219 11.55402539 0.000676027 0.034784308 2.191055173 4.151695572 10.55036956 0.001161649 0.048635284 -2.763691481 2.144193971 15.60534744 7.80336E-05 0.009133163 3.176672268 -0.478841933 12.34357592 0.000442507 0.027438182 4.421892383 -1.42203511 13.74705286 0.000209149 0.017077544 2.056228332 1.20626537 18.37339408 1.81576E-05 0.003388272 -1.999949089 -0.30486312 11.55132468 0.00067701 0.034784308

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

Gene.stable.ID.version Gene.stable.ID Gene.name 1 ENSMUSG00000000184.12 ENSMUSG00000000184 Ccnd2 2 ENSMUSG00000000253.13 ENSMUSG00000000253 Gmpr 3 ENSMUSG00000000278.10 ENSMUSG00000000278 Scpep1 4 ENSMUSG00000000290.13 ENSMUSG00000000290 Itgb2 5 ENSMUSG00000000308.14 ENSMUSG00000000308 Ckmt1 6 ENSMUSG00000000365.9 ENSMUSG00000000365 Rnf17 7 ENSMUSG00000000416.16 ENSMUSG00000000416 Cttnbp2 8 ENSMUSG00000000489.7 ENSMUSG00000000489 Pdgfb 9 ENSMUSG00000000532.11 ENSMUSG00000000532 Acvr1b 10 ENSMUSG00000000561.14 ENSMUSG00000000561 Wdr77 11 ENSMUSG00000000594.7 ENSMUSG00000000594 Gm2a 12 ENSMUSG00000000617.14 ENSMUSG00000000617 Grm6 13 ENSMUSG00000000628.10 ENSMUSG00000000628 Hk2 14 ENSMUSG00000000738.18 ENSMUSG00000000738 Spg7 15 ENSMUSG00000000739.14 ENSMUSG00000000739 Sult5a1 16 ENSMUSG00000000759.14 ENSMUSG00000000759 Tubgcp3 17 ENSMUSG00000000782.15 ENSMUSG00000000782 Tcf7 18 ENSMUSG00000000817.10 ENSMUSG00000000817 Fasl 19 ENSMUSG00000000948.16 ENSMUSG00000000948 Gm38393 20 ENSMUSG00000000958.10 ENSMUSG00000000958 Slc7a7 21 ENSMUSG00000000983.13 ENSMUSG00000000983 Wfdc18 22 ENSMUSG00000001029.15 ENSMUSG00000001029 Icam2 23 ENSMUSG00000001036.17 ENSMUSG00000001036 Epn2 24 ENSMUSG00000001056.3 ENSMUSG00000001056 Nhp2 25 ENSMUSG00000001211.15 ENSMUSG00000001211 Agpat3 26 ENSMUSG00000001300.16 ENSMUSG00000001300 Efnb2 27 ENSMUSG00000001348.15 ENSMUSG00000001348 Acp5 28 ENSMUSG00000001444.2 ENSMUSG00000001444 Tbx21 29 ENSMUSG00000001467.5 ENSMUSG00000001467 Cyp51 30 ENSMUSG00000001542.7 ENSMUSG00000001542 Ell2 31 ENSMUSG00000001622.15 ENSMUSG00000001622 Csn3 32 ENSMUSG00000001672.14 ENSMUSG00000001672 Marveld3 33 ENSMUSG00000001870.15 ENSMUSG00000001870 Ltbp1 34 ENSMUSG00000001901.15 ENSMUSG00000001901 Kcnh6 35 ENSMUSG00000001918.17 ENSMUSG00000001918 Slc1a5 36 ENSMUSG00000001948.10 ENSMUSG00000001948 Spa17 37 ENSMUSG00000002006.12 ENSMUSG00000002006 Pdzd4 38 ENSMUSG00000002033.14 ENSMUSG00000002033 Cd3g 39 ENSMUSG00000002104.11 ENSMUSG00000002104 Rapsn 40 ENSMUSG00000002210.11 ENSMUSG00000002210 Smg9 41 ENSMUSG00000002228.7 ENSMUSG00000002228 Ppm1j 42 ENSMUSG00000002324.8 ENSMUSG00000002324 Rec8 43 ENSMUSG00000002346.16 ENSMUSG00000002346 Slc25a42 44 ENSMUSG00000002477.4 ENSMUSG00000002477 Snrpd1 45 ENSMUSG00000002602.16 ENSMUSG00000002602 Axl 46 ENSMUSG00000002763.16 ENSMUSG00000002763 Pex6 47 ENSMUSG00000002845.14 ENSMUSG00000002845 Tmem39a 48 ENSMUSG00000002885.14 ENSMUSG00000002885 Adgre5 49 ENSMUSG00000002900.16 ENSMUSG00000002900 Lamb1

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

50 ENSMUSG00000002944.15 ENSMUSG00000002944 Cd36 51 ENSMUSG00000002985.16 ENSMUSG00000002985 Apoe 52 ENSMUSG00000003051.13 ENSMUSG00000003051 Elf3 53 ENSMUSG00000003154.15 ENSMUSG00000003154 Foxj2 54 ENSMUSG00000003228.8 ENSMUSG00000003228 Grk5 55 ENSMUSG00000003271.17 ENSMUSG00000003271 Sult2b1 56 ENSMUSG00000003273.14 ENSMUSG00000003273 Car11 57 ENSMUSG00000003355.7 ENSMUSG00000003355 Fkbp11 58 ENSMUSG00000003363.15 ENSMUSG00000003363 Pld3 59 ENSMUSG00000003379.7 ENSMUSG00000003379 Cd79a 60 ENSMUSG00000003418.11 ENSMUSG00000003418 St8sia6 61 ENSMUSG00000003436.11 ENSMUSG00000003436 Dll3 62 ENSMUSG00000003534.17 ENSMUSG00000003534 Ddr1 63 ENSMUSG00000003617.16 ENSMUSG00000003617 Cp 64 ENSMUSG00000003824.12 ENSMUSG00000003824 Syce2 65 ENSMUSG00000003949.16 ENSMUSG00000003949 Hlf 66 ENSMUSG00000003992.15 ENSMUSG00000003992 Ssbp2 67 ENSMUSG00000004110.16 ENSMUSG00000004110 Cacna1e 68 ENSMUSG00000004187.11 ENSMUSG00000004187 Kifc2 69 ENSMUSG00000004328.15 ENSMUSG00000004328 Hif3a 70 ENSMUSG00000004347.16 ENSMUSG00000004347 Pde1c 71 ENSMUSG00000004460.17 ENSMUSG00000004460 Dnajb11 72 ENSMUSG00000004552.16 ENSMUSG00000004552 Ctse 73 ENSMUSG00000004661.15 ENSMUSG00000004661 Arid3b 74 ENSMUSG00000004730.15 ENSMUSG00000004730 Adgre1 75 ENSMUSG00000004951.10 ENSMUSG00000004951 Hspb1 76 ENSMUSG00000004996.9 ENSMUSG00000004996 Mri1 77 ENSMUSG00000005125.13 ENSMUSG00000005125 Ndrg1 78 ENSMUSG00000005237.14 ENSMUSG00000005237 Dnah2 79 ENSMUSG00000005268.20 ENSMUSG00000005268 Prlr 80 ENSMUSG00000005360.14 ENSMUSG00000005360 Slc1a3 81 ENSMUSG00000005364.11 ENSMUSG00000005364 Il5ra 82 ENSMUSG00000005397.8 ENSMUSG00000005397 Nid1 83 ENSMUSG00000005413.8 ENSMUSG00000005413 Hmox1 84 ENSMUSG00000005611.15 ENSMUSG00000005611 Mrvi1 85 ENSMUSG00000005628.12 ENSMUSG00000005628 Tmod4 86 ENSMUSG00000005640.11 ENSMUSG00000005640 Insrr 87 ENSMUSG00000005686.17 ENSMUSG00000005686 Ampd3 88 ENSMUSG00000005696.11 ENSMUSG00000005696 Sh2d1a 89 ENSMUSG00000005951.13 ENSMUSG00000005951 Shpk 90 ENSMUSG00000005952.15 ENSMUSG00000005952 Trpv1 91 ENSMUSG00000006143.12 ENSMUSG00000006143 Upk3bl 92 ENSMUSG00000006154.13 ENSMUSG00000006154 Eps8l1 93 ENSMUSG00000006205.13 ENSMUSG00000006205 Htra1 94 ENSMUSG00000006289.14 ENSMUSG00000006289 Osgep 95 ENSMUSG00000006344.17 ENSMUSG00000006344 Ggt5 96 ENSMUSG00000006360.11 ENSMUSG00000006360 Crip1 97 ENSMUSG00000006378.15 ENSMUSG00000006378 Gcat 98 ENSMUSG00000006435.15 ENSMUSG00000006435 Neurl1a 99 ENSMUSG00000006469.13 ENSMUSG00000006469 Slc34a3 100 ENSMUSG00000006494.11 ENSMUSG00000006494 Pdk1

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

101 ENSMUSG00000006567.11 ENSMUSG00000006567 Atp7b 102 ENSMUSG00000006638.14 ENSMUSG00000006638 Abhd1 103 ENSMUSG00000006651.8 ENSMUSG00000006651 Aplp1 104 ENSMUSG00000006715.11 ENSMUSG00000006715 Gmnn 105 ENSMUSG00000006720.16 ENSMUSG00000006720 Zfp184 106 ENSMUSG00000006800.14 ENSMUSG00000006800 Sulf2 107 ENSMUSG00000006930.15 ENSMUSG00000006930 Hap1 108 ENSMUSG00000007035.15 ENSMUSG00000007035 Msh5 109 ENSMUSG00000007039.12 ENSMUSG00000007039 Ddah2 110 ENSMUSG00000007480.3 ENSMUSG00000007480 Mc5r 111 ENSMUSG00000007888.15 ENSMUSG00000007888 Crlf1 112 ENSMUSG00000008333.12 ENSMUSG00000008333 Snrpb2 113 ENSMUSG00000008393.9 ENSMUSG00000008393 Carhsp1 114 ENSMUSG00000008461.6 ENSMUSG00000008461 Fut1 115 ENSMUSG00000008575.17 ENSMUSG00000008575 Nfib 116 ENSMUSG00000008601.12 ENSMUSG00000008601 Rab25 117 ENSMUSG00000008668.14 ENSMUSG00000008668 Rps18 118 ENSMUSG00000008892.12 ENSMUSG00000008892 Vdac3 119 ENSMUSG00000009035.15 ENSMUSG00000009035 Tmem184b 120 ENSMUSG00000009092.5 ENSMUSG00000009092 Derl3 121 ENSMUSG00000009145.6 ENSMUSG00000009145 Dqx1 122 ENSMUSG00000009376.15 ENSMUSG00000009376 Met 123 ENSMUSG00000009418.15 ENSMUSG00000009418 Nav1 124 ENSMUSG00000009585.18 ENSMUSG00000009585 Apobec3 125 ENSMUSG00000009588.9 ENSMUSG00000009588 St6galnac1 126 ENSMUSG00000009739.17 ENSMUSG00000009739 Pou6f1 127 ENSMUSG00000010021.13 ENSMUSG00000010021 Kif19a 128 ENSMUSG00000010095.13 ENSMUSG00000010095 Slc3a2 129 ENSMUSG00000010142.12 ENSMUSG00000010142 Tnfrsf13b 130 ENSMUSG00000010505.16 ENSMUSG00000010505 Myt1 131 ENSMUSG00000010660.3 ENSMUSG00000010660 Plcd1 132 ENSMUSG00000010830.8 ENSMUSG00000010830 Kdelr3 133 ENSMUSG00000011052.6 ENSMUSG00000011052 1700049J03Rik 134 ENSMUSG00000011148.14 ENSMUSG00000011148 Adssl1 135 ENSMUSG00000011263.16 ENSMUSG00000011263 Exoc3l2 136 ENSMUSG00000011831.16 ENSMUSG00000011831 Evi5 137 ENSMUSG00000012429.9 ENSMUSG00000012429 Mplkip 138 ENSMUSG00000012519.14 ENSMUSG00000012519 Mlkl 139 ENSMUSG00000012819.15 ENSMUSG00000012819 Cdh23 140 ENSMUSG00000013076.17 ENSMUSG00000013076 Amotl1 141 ENSMUSG00000013155.10 ENSMUSG00000013155 Enkd1 142 ENSMUSG00000013584.5 ENSMUSG00000013584 Aldh1a2 143 ENSMUSG00000013643.13 ENSMUSG00000013643 Lypd8 144 ENSMUSG00000013698.12 ENSMUSG00000013698 Pea15a 145 ENSMUSG00000013921.15 ENSMUSG00000013921 Clip3 146 ENSMUSG00000014543.14 ENSMUSG00000014543 Klra17 147 ENSMUSG00000014686.8 ENSMUSG00000014686 Ceacam16 148 ENSMUSG00000014776.7 ENSMUSG00000014776 Nol3 149 ENSMUSG00000014905.4 ENSMUSG00000014905 Dnajb9 150 ENSMUSG00000014959.12 ENSMUSG00000014959 Gorasp2 151 ENSMUSG00000015027.11 ENSMUSG00000015027 Galns

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

152 ENSMUSG00000015224.10 ENSMUSG00000015224 Cyp2j9 153 ENSMUSG00000015314.10 ENSMUSG00000015314 Slamf6 154 ENSMUSG00000015340.10 ENSMUSG00000015340 Cybb 155 ENSMUSG00000015363.13 ENSMUSG00000015363 Trabd 156 ENSMUSG00000015437.5 ENSMUSG00000015437 Gzmb 157 ENSMUSG00000015451.16 ENSMUSG00000015451 C4a 158 ENSMUSG00000015599.9 ENSMUSG00000015599 Ttbk1 159 ENSMUSG00000015850.11 ENSMUSG00000015850 Adamtsl4 160 ENSMUSG00000015854.7 ENSMUSG00000015854 Cd5l 161 ENSMUSG00000015879.8 ENSMUSG00000015879 Fam184b 162 ENSMUSG00000015947.10 ENSMUSG00000015947 Fcgr1 163 ENSMUSG00000015968.17 ENSMUSG00000015968 Cacna1d 164 ENSMUSG00000015981.12 ENSMUSG00000015981 Stk32c 165 ENSMUSG00000016194.14 ENSMUSG00000016194 Hsd11b1 166 ENSMUSG00000016200.14 ENSMUSG00000016200 Syt14 167 ENSMUSG00000016239.11 ENSMUSG00000016239 Lonrf3 168 ENSMUSG00000016349.10 ENSMUSG00000016349 Eef1a2 169 ENSMUSG00000016356.18 ENSMUSG00000016356 Col20a1 170 ENSMUSG00000016494.9 ENSMUSG00000016494 Cd34 171 ENSMUSG00000016503.17 ENSMUSG00000016503 Gtf3a 172 ENSMUSG00000016756.17 ENSMUSG00000016756 Cmah 173 ENSMUSG00000016763.15 ENSMUSG00000016763 Scube1 174 ENSMUSG00000016995.17 ENSMUSG00000016995 Matn4 175 ENSMUSG00000017007.9 ENSMUSG00000017007 Rbpjl 176 ENSMUSG00000017009.3 ENSMUSG00000017009 Sdc4 177 ENSMUSG00000017057.9 ENSMUSG00000017057 Il13ra1 178 ENSMUSG00000017167.6 ENSMUSG00000017167 Cntnap1 179 ENSMUSG00000017286.15 ENSMUSG00000017286 Glod4 180 ENSMUSG00000017400.10 ENSMUSG00000017400 Stac2 181 ENSMUSG00000017446.14 ENSMUSG00000017446 C1qtnf1 182 ENSMUSG00000017607.9 ENSMUSG00000017607 Tns4 183 ENSMUSG00000017639.13 ENSMUSG00000017639 Rab11fip4 184 ENSMUSG00000017718.15 ENSMUSG00000017718 Afmid 185 ENSMUSG00000017754.13 ENSMUSG00000017754 Pltp 186 ENSMUSG00000017765.17 ENSMUSG00000017765 Slc12a4 187 ENSMUSG00000018001.18 ENSMUSG00000018001 Cyth3 188 ENSMUSG00000018102.5 ENSMUSG00000018102 Hist1h2bc 189 ENSMUSG00000018168.8 ENSMUSG00000018168 Ikzf3 190 ENSMUSG00000018387.12 ENSMUSG00000018387 Shroom1 191 ENSMUSG00000018401.17 ENSMUSG00000018401 Mtmr4 192 ENSMUSG00000018425.18 ENSMUSG00000018425 Dhx40 193 ENSMUSG00000018459.15 ENSMUSG00000018459 Slc13a3 194 ENSMUSG00000018470.8 ENSMUSG00000018470 Kcnab3 195 ENSMUSG00000018569.12 ENSMUSG00000018569 Cldn7 196 ENSMUSG00000018581.15 ENSMUSG00000018581 Dnah11 197 ENSMUSG00000018750.14 ENSMUSG00000018750 Zbtb4 198 ENSMUSG00000018800.14 ENSMUSG00000018800 Abca5 199 ENSMUSG00000018861.8 ENSMUSG00000018861 Fdxr 200 ENSMUSG00000018906.14 ENSMUSG00000018906 P4ha2 201 ENSMUSG00000018924.6 ENSMUSG00000018924 Alox15 202 ENSMUSG00000018925.3 ENSMUSG00000018925 Heatr9

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

203 ENSMUSG00000019055.15 ENSMUSG00000019055 Plod1 204 ENSMUSG00000019066.13 ENSMUSG00000019066 Rab3d 205 ENSMUSG00000019302.16 ENSMUSG00000019302 Atp6v0a1 206 ENSMUSG00000019312.10 ENSMUSG00000019312 Grb7 207 ENSMUSG00000019461.12 ENSMUSG00000019461 Plscr3 208 ENSMUSG00000019539.11 ENSMUSG00000019539 Rcn3 209 ENSMUSG00000019564.12 ENSMUSG00000019564 Arid3a 210 ENSMUSG00000019647.16 ENSMUSG00000019647 Sema6a 211 ENSMUSG00000019659.8 ENSMUSG00000019659 Ccdc12 212 ENSMUSG00000019817.18 ENSMUSG00000019817 Plagl1 213 ENSMUSG00000019836.5 ENSMUSG00000019836 Amd-ps4 214 ENSMUSG00000019846.11 ENSMUSG00000019846 Lama4 215 ENSMUSG00000019866.14 ENSMUSG00000019866 Crybg1 216 ENSMUSG00000019873.8 ENSMUSG00000019873 Reep3 217 ENSMUSG00000019935.16 ENSMUSG00000019935 Slc17a8 218 ENSMUSG00000019944.14 ENSMUSG00000019944 Rhobtb1 219 ENSMUSG00000019945.10 ENSMUSG00000019945 Cabcoco1 220 ENSMUSG00000019987.9 ENSMUSG00000019987 Arg1 221 ENSMUSG00000019992.8 ENSMUSG00000019992 Mtfr2 222 ENSMUSG00000019996.17 ENSMUSG00000019996 Map7 223 ENSMUSG00000020003.16 ENSMUSG00000020003 Pex7 224 ENSMUSG00000020017.14 ENSMUSG00000020017 Hal 225 ENSMUSG00000020019.4 ENSMUSG00000020019 Ntn4 226 ENSMUSG00000020021.4 ENSMUSG00000020021 Fgd6 227 ENSMUSG00000020023.18 ENSMUSG00000020023 Tmcc3 228 ENSMUSG00000020027.18 ENSMUSG00000020027 Socs2 229 ENSMUSG00000020029.6 ENSMUSG00000020029 Nudt4 230 ENSMUSG00000020044.13 ENSMUSG00000020044 Timp3 231 ENSMUSG00000020048.13 ENSMUSG00000020048 Hsp90b1 232 ENSMUSG00000020053.18 ENSMUSG00000020053 Igf1 233 ENSMUSG00000020083.13 ENSMUSG00000020083 Fam241b 234 ENSMUSG00000020101.14 ENSMUSG00000020101 Vsir 235 ENSMUSG00000020142.12 ENSMUSG00000020142 Slc1a4 236 ENSMUSG00000020154.10 ENSMUSG00000020154 Ptprb 237 ENSMUSG00000020160.18 ENSMUSG00000020160 Meis1 238 ENSMUSG00000020180.10 ENSMUSG00000020180 Snrpd3 239 ENSMUSG00000020182.16 ENSMUSG00000020182 Ddc 240 ENSMUSG00000020205.8 ENSMUSG00000020205 Phlda1 241 ENSMUSG00000020246.13 ENSMUSG00000020246 Hcfc2 242 ENSMUSG00000020256.14 ENSMUSG00000020256 Aldh1l2 243 ENSMUSG00000020267.6 ENSMUSG00000020267 Hint1 244 ENSMUSG00000020268.13 ENSMUSG00000020268 Lyrm7 245 ENSMUSG00000020282.18 ENSMUSG00000020282 Rhbdf1 246 ENSMUSG00000020297.10 ENSMUSG00000020297 Nsg2 247 ENSMUSG00000020300.14 ENSMUSG00000020300 Cpeb4 248 ENSMUSG00000020303.2 ENSMUSG00000020303 Stc2 249 ENSMUSG00000020333.17 ENSMUSG00000020333 Acsl6 250 ENSMUSG00000020376.16 ENSMUSG00000020376 Rnf130 251 ENSMUSG00000020377.15 ENSMUSG00000020377 Ltc4s 252 ENSMUSG00000020395.13 ENSMUSG00000020395 Itk 253 ENSMUSG00000020396.8 ENSMUSG00000020396 Nefh

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

254 ENSMUSG00000020401.6 ENSMUSG00000020401 Fam71b 255 ENSMUSG00000020419.11 ENSMUSG00000020419 Hormad2 256 ENSMUSG00000020423.6 ENSMUSG00000020423 Btg2 257 ENSMUSG00000020447.5 ENSMUSG00000020447 Npc1l1 258 ENSMUSG00000020448.16 ENSMUSG00000020448 Rnf185 259 ENSMUSG00000020474.11 ENSMUSG00000020474 Polm 260 ENSMUSG00000020475.3 ENSMUSG00000020475 Pgam2 261 ENSMUSG00000020482.4 ENSMUSG00000020482 Ccdc117 262 ENSMUSG00000020484.18 ENSMUSG00000020484 Xbp1 263 ENSMUSG00000020491.15 ENSMUSG00000020491 2810021J22Rik 264 ENSMUSG00000020528.14 ENSMUSG00000020528 Prpsap2 265 ENSMUSG00000020546.14 ENSMUSG00000020546 Stxbp4 266 ENSMUSG00000020553.8 ENSMUSG00000020553 Pctp 267 ENSMUSG00000020576.10 ENSMUSG00000020576 Nbas 268 ENSMUSG00000020592.14 ENSMUSG00000020592 Sdc1 269 ENSMUSG00000020604.13 ENSMUSG00000020604 Arsg 270 ENSMUSG00000020620.14 ENSMUSG00000020620 Abca8b 271 ENSMUSG00000020628.16 ENSMUSG00000020628 Trappc12 272 ENSMUSG00000020642.13 ENSMUSG00000020642 Rnf144a 273 ENSMUSG00000020644.9 ENSMUSG00000020644 Id2 274 ENSMUSG00000020681.14 ENSMUSG00000020681 Ace 275 ENSMUSG00000020709.15 ENSMUSG00000020709 Adap2 276 ENSMUSG00000020712.11 ENSMUSG00000020712 Tcam1 277 ENSMUSG00000020798.14 ENSMUSG00000020798 Spns3 278 ENSMUSG00000020808.3 ENSMUSG00000020808 Pimreg 279 ENSMUSG00000020810.5 ENSMUSG00000020810 Cygb 280 ENSMUSG00000020811.16 ENSMUSG00000020811 Wscd1 281 ENSMUSG00000020814.13 ENSMUSG00000020814 Mxra7 282 ENSMUSG00000020821.17 ENSMUSG00000020821 Kif1c 283 ENSMUSG00000020866.17 ENSMUSG00000020866 Cacna1g 284 ENSMUSG00000020877.11 ENSMUSG00000020877 Scrn2 285 ENSMUSG00000020884.15 ENSMUSG00000020884 Asgr1 286 ENSMUSG00000020891.11 ENSMUSG00000020891 Alox8 287 ENSMUSG00000020898.18 ENSMUSG00000020898 Ctc1 288 ENSMUSG00000020900.15 ENSMUSG00000020900 Myh10 289 ENSMUSG00000020901.13 ENSMUSG00000020901 Pik3r5 290 ENSMUSG00000020908.14 ENSMUSG00000020908 Myh3 291 ENSMUSG00000020911.14 ENSMUSG00000020911 Krt19 292 ENSMUSG00000020926.16 ENSMUSG00000020926 Adam11 293 ENSMUSG00000020932.14 ENSMUSG00000020932 Gfap 294 ENSMUSG00000020937.14 ENSMUSG00000020937 Plcd3 295 ENSMUSG00000020949.9 ENSMUSG00000020949 Fkbp3 296 ENSMUSG00000020964.14 ENSMUSG00000020964 Sel1l 297 ENSMUSG00000021054.6 ENSMUSG00000021054 Sgpp1 298 ENSMUSG00000021061.15 ENSMUSG00000021061 Sptb 299 ENSMUSG00000021062.15 ENSMUSG00000021062 Rab15 300 ENSMUSG00000021098.14 ENSMUSG00000021098 4930447C04Rik 301 ENSMUSG00000021113.5 ENSMUSG00000021113 Snapc1 302 ENSMUSG00000021127.7 ENSMUSG00000021127 Zfp36l1 303 ENSMUSG00000021147.17 ENSMUSG00000021147 Wdr37 304 ENSMUSG00000021176.6 ENSMUSG00000021176 Efcab11

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

305 ENSMUSG00000021187.14 ENSMUSG00000021187 Tc2n 306 ENSMUSG00000021190.14 ENSMUSG00000021190 Lgmn 307 ENSMUSG00000021194.6 ENSMUSG00000021194 Chga 308 ENSMUSG00000021196.14 ENSMUSG00000021196 Pfkp 309 ENSMUSG00000021279.5 ENSMUSG00000021279 Cdc42bpb 310 ENSMUSG00000021290.6 ENSMUSG00000021290 Atp5mpl 311 ENSMUSG00000021294.7 ENSMUSG00000021294 Kif26a 312 ENSMUSG00000021298.8 ENSMUSG00000021298 Gpr132 313 ENSMUSG00000021319.7 ENSMUSG00000021319 Sfrp4 314 ENSMUSG00000021322.8 ENSMUSG00000021322 Aoah 315 ENSMUSG00000021356.10 ENSMUSG00000021356 Irf4 316 ENSMUSG00000021360.16 ENSMUSG00000021360 Gcnt2 317 ENSMUSG00000021365.15 ENSMUSG00000021365 Nedd9 318 ENSMUSG00000021403.3 ENSMUSG00000021403 Serpinb9b 319 ENSMUSG00000021461.17 ENSMUSG00000021461 Fancc 320 ENSMUSG00000021476.9 ENSMUSG00000021476 Habp4 321 ENSMUSG00000021589.13 ENSMUSG00000021589 Rhobtb3 322 ENSMUSG00000021610.8 ENSMUSG00000021610 Clptm1l 323 ENSMUSG00000021614.16 ENSMUSG00000021614 Vcan 324 ENSMUSG00000021619.6 ENSMUSG00000021619 Atg10 325 ENSMUSG00000021624.9 ENSMUSG00000021624 Cd180 326 ENSMUSG00000021640.6 ENSMUSG00000021640 Naip1 327 ENSMUSG00000021643.15 ENSMUSG00000021643 Serf1 328 ENSMUSG00000021670.14 ENSMUSG00000021670 Hmgcr 329 ENSMUSG00000021714.15 ENSMUSG00000021714 Cenpk 330 ENSMUSG00000021730.8 ENSMUSG00000021730 Hcn1 331 ENSMUSG00000021747.12 ENSMUSG00000021747 4930452B06Rik 332 ENSMUSG00000021754.17 ENSMUSG00000021754 Map3k1 333 ENSMUSG00000021756.12 ENSMUSG00000021756 Il6st 334 ENSMUSG00000021758.14 ENSMUSG00000021758 Ddx4 335 ENSMUSG00000021768.15 ENSMUSG00000021768 Dusp13 336 ENSMUSG00000021770.11 ENSMUSG00000021770 Samd8 337 ENSMUSG00000021779.17 ENSMUSG00000021779 Thrb 338 ENSMUSG00000021807.6 ENSMUSG00000021807 Rtraf 339 ENSMUSG00000021831.9 ENSMUSG00000021831 Ero1l 340 ENSMUSG00000021903.11 ENSMUSG00000021903 Galnt15 341 ENSMUSG00000021908.10 ENSMUSG00000021908 Gm6768 342 ENSMUSG00000021913.8 ENSMUSG00000021913 Ogdhl 343 ENSMUSG00000021932.13 ENSMUSG00000021932 Rnaseh2b 344 ENSMUSG00000021933.11 ENSMUSG00000021933 Gucy1b2 345 ENSMUSG00000021965.3 ENSMUSG00000021965 Ska3 346 ENSMUSG00000021990.15 ENSMUSG00000021990 Spata13 347 ENSMUSG00000022014.15 ENSMUSG00000022014 Epsti1 348 ENSMUSG00000022070.7 ENSMUSG00000022070 Bora 349 ENSMUSG00000022092.11 ENSMUSG00000022092 Ppp3cc 350 ENSMUSG00000022136.8 ENSMUSG00000022136 Dnajc3 351 ENSMUSG00000022177.9 ENSMUSG00000022177 Haus4 352 ENSMUSG00000022180.7 ENSMUSG00000022180 Slc7a8 353 ENSMUSG00000022193.7 ENSMUSG00000022193 Psmb5 354 ENSMUSG00000022221.14 ENSMUSG00000022221 Ripk3 355 ENSMUSG00000022225.7 ENSMUSG00000022225 Cma1

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

356 ENSMUSG00000022240.10 ENSMUSG00000022240 Ctnnd2 357 ENSMUSG00000022270.16 ENSMUSG00000022270 Retreg1 358 ENSMUSG00000022324.15 ENSMUSG00000022324 Matn2 359 ENSMUSG00000022325.14 ENSMUSG00000022325 Pop1 360 ENSMUSG00000022351.14 ENSMUSG00000022351 Sqle 361 ENSMUSG00000022367.7 ENSMUSG00000022367 Has2 362 ENSMUSG00000022371.16 ENSMUSG00000022371 Col14a1 363 ENSMUSG00000022383.13 ENSMUSG00000022383 Ppara 364 ENSMUSG00000022407.10 ENSMUSG00000022407 Adsl 365 ENSMUSG00000022408.7 ENSMUSG00000022408 Fam83f 366 ENSMUSG00000022415.12 ENSMUSG00000022415 Syngr1 367 ENSMUSG00000022422.13 ENSMUSG00000022422 Dscc1 368 ENSMUSG00000022438.6 ENSMUSG00000022438 Parvb 369 ENSMUSG00000022456.16 ENSMUSG00000022456 43711 370 ENSMUSG00000022468.12 ENSMUSG00000022468 Endou 371 ENSMUSG00000022469.17 ENSMUSG00000022469 Rapgef3 372 ENSMUSG00000022471.14 ENSMUSG00000022471 Xrcc6 373 ENSMUSG00000022474.15 ENSMUSG00000022474 Pmm1 374 ENSMUSG00000022496.5 ENSMUSG00000022496 Tnfrsf17 375 ENSMUSG00000022498.16 ENSMUSG00000022498 Txndc11 376 ENSMUSG00000022512.3 ENSMUSG00000022512 Cldn1 377 ENSMUSG00000022537.18 ENSMUSG00000022537 Tmem44 378 ENSMUSG00000022584.14 ENSMUSG00000022584 Ly6c2 379 ENSMUSG00000022586.11 ENSMUSG00000022586 Ly6i 380 ENSMUSG00000022621.16 ENSMUSG00000022621 Rabl2 381 ENSMUSG00000022661.14 ENSMUSG00000022661 Cd200 382 ENSMUSG00000022686.14 ENSMUSG00000022686 B3gnt5 383 ENSMUSG00000022696.17 ENSMUSG00000022696 Sidt1 384 ENSMUSG00000022701.18 ENSMUSG00000022701 Ccdc191 385 ENSMUSG00000022742.6 ENSMUSG00000022742 Cpox 386 ENSMUSG00000022762.18 ENSMUSG00000022762 Ncam2 387 ENSMUSG00000022769.9 ENSMUSG00000022769 Sdf2l1 388 ENSMUSG00000022818.13 ENSMUSG00000022818 Cyp2ab1 389 ENSMUSG00000022838.14 ENSMUSG00000022838 Eaf2 390 ENSMUSG00000022865.14 ENSMUSG00000022865 Cxadr 391 ENSMUSG00000022876.18 ENSMUSG00000022876 Samsn1 392 ENSMUSG00000022885.16 ENSMUSG00000022885 St6gal1 393 ENSMUSG00000022938.8 ENSMUSG00000022938 Fam3b 394 ENSMUSG00000022945.12 ENSMUSG00000022945 Chaf1b 395 ENSMUSG00000022948.16 ENSMUSG00000022948 Setd4 396 ENSMUSG00000022964.14 ENSMUSG00000022964 Tmem50b 397 ENSMUSG00000022995.16 ENSMUSG00000022995 Enah 398 ENSMUSG00000023031.8 ENSMUSG00000023031 Cela1 399 ENSMUSG00000023036.14 ENSMUSG00000023036 Pcdhgc4 400 ENSMUSG00000023072.14 ENSMUSG00000023072 Cep89 401 ENSMUSG00000023075.9 ENSMUSG00000023075 Akirin1 402 ENSMUSG00000023104.9 ENSMUSG00000023104 Rfc2 403 ENSMUSG00000023132.8 ENSMUSG00000023132 Gzma 404 ENSMUSG00000023232.17 ENSMUSG00000023232 Serinc2 405 ENSMUSG00000023236.7 ENSMUSG00000023236 Scg5 406 ENSMUSG00000023247.2 ENSMUSG00000023247 Guca2a

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

407 ENSMUSG00000023267.10 ENSMUSG00000023267 Gabrr2 408 ENSMUSG00000023272.4 ENSMUSG00000023272 Creld2 409 ENSMUSG00000023274.14 ENSMUSG00000023274 Cd4 410 ENSMUSG00000023328.14 ENSMUSG00000023328 Ache 411 ENSMUSG00000023345.17 ENSMUSG00000023345 Poc1a 412 ENSMUSG00000023411.12 ENSMUSG00000023411 Nfatc4 413 ENSMUSG00000023505.13 ENSMUSG00000023505 Cdca3 414 ENSMUSG00000023764.18 ENSMUSG00000023764 Sfi1 415 ENSMUSG00000023791.16 ENSMUSG00000023791 Pigx 416 ENSMUSG00000023809.10 ENSMUSG00000023809 Rps6ka2 417 ENSMUSG00000023828.3 ENSMUSG00000023828 Slc22a3 418 ENSMUSG00000023830.14 ENSMUSG00000023830 Igf2r 419 ENSMUSG00000023886.10 ENSMUSG00000023886 Smoc2 420 ENSMUSG00000023902.18 ENSMUSG00000023902 Zscan10 421 ENSMUSG00000023908.8 ENSMUSG00000023908 Pkmyt1 422 ENSMUSG00000023926.8 ENSMUSG00000023926 Rhag 423 ENSMUSG00000023979.14 ENSMUSG00000023979 Guca1b 424 ENSMUSG00000023982.8 ENSMUSG00000023982 Guca1a 425 ENSMUSG00000023999.14 ENSMUSG00000023999 Kif6 426 ENSMUSG00000024033.9 ENSMUSG00000024033 Rsph1 427 ENSMUSG00000024034.12 ENSMUSG00000024034 Tmprss3 428 ENSMUSG00000024049.15 ENSMUSG00000024049 Myom1 429 ENSMUSG00000024053.11 ENSMUSG00000024053 Emilin2 430 ENSMUSG00000024059.10 ENSMUSG00000024059 Clip4 431 ENSMUSG00000024064.14 ENSMUSG00000024064 Galnt14 432 ENSMUSG00000024065.8 ENSMUSG00000024065 Ehd3 433 ENSMUSG00000024066.9 ENSMUSG00000024066 Xdh 434 ENSMUSG00000024085.13 ENSMUSG00000024085 Man2a1 435 ENSMUSG00000024109.18 ENSMUSG00000024109 Nrxn1 436 ENSMUSG00000024112.16 ENSMUSG00000024112 Cacna1h 437 ENSMUSG00000024114.15 ENSMUSG00000024114 Prss41 438 ENSMUSG00000024130.15 ENSMUSG00000024130 Abca3 439 ENSMUSG00000024140.9 ENSMUSG00000024140 Epas1 440 ENSMUSG00000024151.13 ENSMUSG00000024151 Msh2 441 ENSMUSG00000024155.7 ENSMUSG00000024155 Meiob 442 ENSMUSG00000024172.10 ENSMUSG00000024172 St6gal2 443 ENSMUSG00000024177.8 ENSMUSG00000024177 Nme4 444 ENSMUSG00000024190.6 ENSMUSG00000024190 Dusp1 445 ENSMUSG00000024210.2 ENSMUSG00000024210 Ip6k3 446 ENSMUSG00000024248.13 ENSMUSG00000024248 Cox7a2l 447 ENSMUSG00000024304.14 ENSMUSG00000024304 Cdh2 448 ENSMUSG00000024327.15 ENSMUSG00000024327 Slc39a7 449 ENSMUSG00000024347.16 ENSMUSG00000024347 Psd2 450 ENSMUSG00000024353.4 ENSMUSG00000024353 Mzb1 451 ENSMUSG00000024371.14 ENSMUSG00000024371 C2 452 ENSMUSG00000024381.15 ENSMUSG00000024381 Bin1 453 ENSMUSG00000024425.3 ENSMUSG00000024425 Ndfip1 454 ENSMUSG00000024426.17 ENSMUSG00000024426 Atat1 455 ENSMUSG00000024448.14 ENSMUSG00000024448 H2-M10.1 456 ENSMUSG00000024451.8 ENSMUSG00000024451 Arap3 457 ENSMUSG00000024480.8 ENSMUSG00000024480 Ap3s1

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

458 ENSMUSG00000024481.4 ENSMUSG00000024481 Lvrn 459 ENSMUSG00000024521.7 ENSMUSG00000024521 Pmaip1 460 ENSMUSG00000024525.6 ENSMUSG00000024525 Impa2 461 ENSMUSG00000024533.16 ENSMUSG00000024533 Spire1 462 ENSMUSG00000024544.8 ENSMUSG00000024544 Ldlrad4 463 ENSMUSG00000024548.11 ENSMUSG00000024548 Setbp1 464 ENSMUSG00000024597.10 ENSMUSG00000024597 Slc12a2 465 ENSMUSG00000024598.8 ENSMUSG00000024598 Fbn2 466 ENSMUSG00000024620.11 ENSMUSG00000024620 Pdgfrb 467 ENSMUSG00000024621.15 ENSMUSG00000024621 Csf1r 468 ENSMUSG00000024672.11 ENSMUSG00000024672 Ms4a7 469 ENSMUSG00000024679.10 ENSMUSG00000024679 Ms4a6d 470 ENSMUSG00000024726.9 ENSMUSG00000024726 Carnmt1 471 ENSMUSG00000024749.8 ENSMUSG00000024749 Tmc1 472 ENSMUSG00000024791.10 ENSMUSG00000024791 Cdca5 473 ENSMUSG00000024805.16 ENSMUSG00000024805 Pcgf5 474 ENSMUSG00000024807.17 ENSMUSG00000024807 Syvn1 475 ENSMUSG00000024844.14 ENSMUSG00000024844 Banf1 476 ENSMUSG00000024851.13 ENSMUSG00000024851 Pitpnm1 477 ENSMUSG00000024897.8 ENSMUSG00000024897 Apba1 478 ENSMUSG00000024901.14 ENSMUSG00000024901 Peli3 479 ENSMUSG00000024909.14 ENSMUSG00000024909 Efemp2 480 ENSMUSG00000024910.4 ENSMUSG00000024910 Ctsw 481 ENSMUSG00000024924.14 ENSMUSG00000024924 Vldlr 482 ENSMUSG00000024987.5 ENSMUSG00000024987 Cyp26a1 483 ENSMUSG00000025014.12 ENSMUSG00000025014 Dntt 484 ENSMUSG00000025020.11 ENSMUSG00000025020 Slit1 485 ENSMUSG00000025036.6 ENSMUSG00000025036 Sfxn2 486 ENSMUSG00000025044.16 ENSMUSG00000025044 Msr1 487 ENSMUSG00000025064.14 ENSMUSG00000025064 Col17a1 488 ENSMUSG00000025083.18 ENSMUSG00000025083 Afap1l2 489 ENSMUSG00000025086.12 ENSMUSG00000025086 Trub1 490 ENSMUSG00000025092.6 ENSMUSG00000025092 Hspa12a 491 ENSMUSG00000025137.15 ENSMUSG00000025137 Pcyt2 492 ENSMUSG00000025140.15 ENSMUSG00000025140 Pycr1 493 ENSMUSG00000025163.6 ENSMUSG00000025163 Cd7 494 ENSMUSG00000025188.15 ENSMUSG00000025188 Hps1 495 ENSMUSG00000025203.5 ENSMUSG00000025203 Scd2 496 ENSMUSG00000025217.15 ENSMUSG00000025217 Btrc 497 ENSMUSG00000025218.6 ENSMUSG00000025218 Poll 498 ENSMUSG00000025227.14 ENSMUSG00000025227 Mfsd13a 499 ENSMUSG00000025289.15 ENSMUSG00000025289 Prdx4 500 ENSMUSG00000025329.3 ENSMUSG00000025329 Padi1 501 ENSMUSG00000025348.9 ENSMUSG00000025348 Itga7 502 ENSMUSG00000025352.6 ENSMUSG00000025352 Gdf11 503 ENSMUSG00000025355.7 ENSMUSG00000025355 Mmp19 504 ENSMUSG00000025357.8 ENSMUSG00000025357 Dgka 505 ENSMUSG00000025375.15 ENSMUSG00000025375 Aatk 506 ENSMUSG00000025427.14 ENSMUSG00000025427 Rnf165 507 ENSMUSG00000025461.11 ENSMUSG00000025461 Cd163l1 508 ENSMUSG00000025486.17 ENSMUSG00000025486 Sirt3

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

509 ENSMUSG00000025497.15 ENSMUSG00000025497 Cdhr5 510 ENSMUSG00000025504.14 ENSMUSG00000025504 Eps8l2 511 ENSMUSG00000025511.14 ENSMUSG00000025511 Tspan4 512 ENSMUSG00000025512.15 ENSMUSG00000025512 Chid1 513 ENSMUSG00000025555.14 ENSMUSG00000025555 Farp1 514 ENSMUSG00000025592.17 ENSMUSG00000025592 Dach2 515 ENSMUSG00000025658.16 ENSMUSG00000025658 Cnksr2 516 ENSMUSG00000025702.15 ENSMUSG00000025702 43532 517 ENSMUSG00000025743.14 ENSMUSG00000025743 Sdc3 518 ENSMUSG00000025747.12 ENSMUSG00000025747 Tyms 519 ENSMUSG00000025790.14 ENSMUSG00000025790 Slco3a1 520 ENSMUSG00000025810.9 ENSMUSG00000025810 Nrp1 521 ENSMUSG00000025823.9 ENSMUSG00000025823 Pdia4 522 ENSMUSG00000025876.15 ENSMUSG00000025876 Unc5a 523 ENSMUSG00000025932.14 ENSMUSG00000025932 Eya1 524 ENSMUSG00000025936.15 ENSMUSG00000025936 Gm4956 525 ENSMUSG00000025940.6 ENSMUSG00000025940 Tmem70 526 ENSMUSG00000025949.16 ENSMUSG00000025949 Pikfyve 527 ENSMUSG00000025964.15 ENSMUSG00000025964 Adam23 528 ENSMUSG00000025969.15 ENSMUSG00000025969 Nrp2 529 ENSMUSG00000025993.10 ENSMUSG00000025993 Slc40a1 530 ENSMUSG00000026000.16 ENSMUSG00000026000 Lancl1 531 ENSMUSG00000026003.5 ENSMUSG00000026003 Acadl 532 ENSMUSG00000026012.2 ENSMUSG00000026012 Cd28 533 ENSMUSG00000026014.15 ENSMUSG00000026014 Raph1 534 ENSMUSG00000026024.14 ENSMUSG00000026024 Als2 535 ENSMUSG00000026070.15 ENSMUSG00000026070 Il18r1 536 ENSMUSG00000026072.12 ENSMUSG00000026072 Il1r1 537 ENSMUSG00000026090.16 ENSMUSG00000026090 2010300C02Rik 538 ENSMUSG00000026113.17 ENSMUSG00000026113 Inpp4a 539 ENSMUSG00000026153.15 ENSMUSG00000026153 Fam135a 540 ENSMUSG00000026167.14 ENSMUSG00000026167 Wnt10a 541 ENSMUSG00000026175.12 ENSMUSG00000026175 Vil1 542 ENSMUSG00000026193.15 ENSMUSG00000026193 Fn1 543 ENSMUSG00000026207.16 ENSMUSG00000026207 Speg 544 ENSMUSG00000026223.15 ENSMUSG00000026223 Itm2c 545 ENSMUSG00000026271.15 ENSMUSG00000026271 Gpr35 546 ENSMUSG00000026303.6 ENSMUSG00000026303 Mlph 547 ENSMUSG00000026308.8 ENSMUSG00000026308 Klhl30 548 ENSMUSG00000026357.3 ENSMUSG00000026357 Rgs18 549 ENSMUSG00000026365.15 ENSMUSG00000026365 Cfh 550 ENSMUSG00000026368.6 ENSMUSG00000026368 F13b 551 ENSMUSG00000026385.16 ENSMUSG00000026385 Dbi 552 ENSMUSG00000026393.10 ENSMUSG00000026393 Nek7 553 ENSMUSG00000026398.14 ENSMUSG00000026398 Nr5a2 554 ENSMUSG00000026415.11 ENSMUSG00000026415 Fcamr 555 ENSMUSG00000026418.16 ENSMUSG00000026418 Tnni1 556 ENSMUSG00000026421.14 ENSMUSG00000026421 Csrp1 557 ENSMUSG00000026450.14 ENSMUSG00000026450 Chit1 558 ENSMUSG00000026456.18 ENSMUSG00000026456 Cyb5r1 559 ENSMUSG00000026458.13 ENSMUSG00000026458 Ppfia4

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

560 ENSMUSG00000026459.5 ENSMUSG00000026459 Myog 561 ENSMUSG00000026478.14 ENSMUSG00000026478 Lamc1 562 ENSMUSG00000026483.13 ENSMUSG00000026483 Fam129a 563 ENSMUSG00000026504.17 ENSMUSG00000026504 Sdccag8 564 ENSMUSG00000026532.7 ENSMUSG00000026532 Spta1 565 ENSMUSG00000026535.9 ENSMUSG00000026535 Ifi202b 566 ENSMUSG00000026536.9 ENSMUSG00000026536 Ifi211 567 ENSMUSG00000026548.4 ENSMUSG00000026548 Slamf9 568 ENSMUSG00000026573.7 ENSMUSG00000026573 Xcl1 569 ENSMUSG00000026576.12 ENSMUSG00000026576 Atp1b1 570 ENSMUSG00000026579.8 ENSMUSG00000026579 F5 571 ENSMUSG00000026580.16 ENSMUSG00000026580 Selp 572 ENSMUSG00000026582.6 ENSMUSG00000026582 Sele 573 ENSMUSG00000026586.16 ENSMUSG00000026586 Prrx1 574 ENSMUSG00000026600.12 ENSMUSG00000026600 Soat1 575 ENSMUSG00000026602.9 ENSMUSG00000026602 Nphs2 576 ENSMUSG00000026620.11 ENSMUSG00000026620 Mark1 577 ENSMUSG00000026627.7 ENSMUSG00000026627 Tmem206 578 ENSMUSG00000026643.16 ENSMUSG00000026643 Nmt2 579 ENSMUSG00000026649.14 ENSMUSG00000026649 Cfap126 580 ENSMUSG00000026663.6 ENSMUSG00000026663 Atf6 581 ENSMUSG00000026675.12 ENSMUSG00000026675 Hsd17b7 582 ENSMUSG00000026712.3 ENSMUSG00000026712 Mrc1 583 ENSMUSG00000026764.15 ENSMUSG00000026764 Kif5c 584 ENSMUSG00000026765.12 ENSMUSG00000026765 Lypd6b 585 ENSMUSG00000026768.10 ENSMUSG00000026768 Itga8 586 ENSMUSG00000026771.14 ENSMUSG00000026771 Spopl 587 ENSMUSG00000026833.18 ENSMUSG00000026833 Olfm1 588 ENSMUSG00000026837.15 ENSMUSG00000026837 Col5a1 589 ENSMUSG00000026839.17 ENSMUSG00000026839 Upp2 590 ENSMUSG00000026853.15 ENSMUSG00000026853 Crat 591 ENSMUSG00000026875.14 ENSMUSG00000026875 Traf1 592 ENSMUSG00000026880.11 ENSMUSG00000026880 Stom 593 ENSMUSG00000026921.18 ENSMUSG00000026921 Egfl7 594 ENSMUSG00000026932.14 ENSMUSG00000026932 Nacc2 595 ENSMUSG00000026946.9 ENSMUSG00000026946 Nmi 596 ENSMUSG00000026970.16 ENSMUSG00000026970 Rbms1 597 ENSMUSG00000027002.13 ENSMUSG00000027002 Nckap1 598 ENSMUSG00000027010.16 ENSMUSG00000027010 Slc25a12 599 ENSMUSG00000027011.14 ENSMUSG00000027011 Ube2e3 600 ENSMUSG00000027035.10 ENSMUSG00000027035 Cers6 601 ENSMUSG00000027072.13 ENSMUSG00000027072 Prg3 602 ENSMUSG00000027073.5 ENSMUSG00000027073 Prg2 603 ENSMUSG00000027133.3 ENSMUSG00000027133 Nop10 604 ENSMUSG00000027173.7 ENSMUSG00000027173 Depdc7 605 ENSMUSG00000027200.17 ENSMUSG00000027200 Sema6d 606 ENSMUSG00000027203.15 ENSMUSG00000027203 Dut 607 ENSMUSG00000027208.14 ENSMUSG00000027208 Fgf7 608 ENSMUSG00000027219.13 ENSMUSG00000027219 Slc28a2 609 ENSMUSG00000027221.5 ENSMUSG00000027221 Chst1 610 ENSMUSG00000027227.7 ENSMUSG00000027227 Sord

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

611 ENSMUSG00000027230.9 ENSMUSG00000027230 Creb3l1 612 ENSMUSG00000027233.4 ENSMUSG00000027233 Patl2 613 ENSMUSG00000027236.8 ENSMUSG00000027236 Eif3j1 614 ENSMUSG00000027254.13 ENSMUSG00000027254 Map1a 615 ENSMUSG00000027297.14 ENSMUSG00000027297 Ltk 616 ENSMUSG00000027313.3 ENSMUSG00000027313 Chac1 617 ENSMUSG00000027317.8 ENSMUSG00000027317 Ppp1r14d 618 ENSMUSG00000027322.11 ENSMUSG00000027322 Siglec1 619 ENSMUSG00000027323.10 ENSMUSG00000027323 Rad51 620 ENSMUSG00000027331.15 ENSMUSG00000027331 Knstrn 621 ENSMUSG00000027332.11 ENSMUSG00000027332 Ivd 622 ENSMUSG00000027333.18 ENSMUSG00000027333 Smox 623 ENSMUSG00000027347.18 ENSMUSG00000027347 Rasgrp1 624 ENSMUSG00000027359.16 ENSMUSG00000027359 Slc27a2 625 ENSMUSG00000027361.15 ENSMUSG00000027361 Gabpb1 626 ENSMUSG00000027376.15 ENSMUSG00000027376 Prom2 627 ENSMUSG00000027412.12 ENSMUSG00000027412 Lpin3 628 ENSMUSG00000027429.16 ENSMUSG00000027429 Sec23b 629 ENSMUSG00000027430.12 ENSMUSG00000027430 Dtd1 630 ENSMUSG00000027438.14 ENSMUSG00000027438 Napb 631 ENSMUSG00000027454.10 ENSMUSG00000027454 Gins1 632 ENSMUSG00000027457.15 ENSMUSG00000027457 Snph 633 ENSMUSG00000027472.14 ENSMUSG00000027472 Pdrg1 634 ENSMUSG00000027478.15 ENSMUSG00000027478 Dnmt3b 635 ENSMUSG00000027487.11 ENSMUSG00000027487 Cdk5rap1 636 ENSMUSG00000027505.2 ENSMUSG00000027505 Fam209 637 ENSMUSG00000027514.14 ENSMUSG00000027514 Zbp1 638 ENSMUSG00000027524.9 ENSMUSG00000027524 Edn3 639 ENSMUSG00000027525.17 ENSMUSG00000027525 Phactr3 640 ENSMUSG00000027546.15 ENSMUSG00000027546 Atp9a 641 ENSMUSG00000027556.15 ENSMUSG00000027556 Car1 642 ENSMUSG00000027579.6 ENSMUSG00000027579 Srms 643 ENSMUSG00000027597.15 ENSMUSG00000027597 Ahcy 644 ENSMUSG00000027603.15 ENSMUSG00000027603 Ggt7 645 ENSMUSG00000027605.18 ENSMUSG00000027605 Acss2 646 ENSMUSG00000027610.17 ENSMUSG00000027610 Gss 647 ENSMUSG00000027663.12 ENSMUSG00000027663 Zmat3 648 ENSMUSG00000027708.14 ENSMUSG00000027708 Dcun1d1 649 ENSMUSG00000027714.11 ENSMUSG00000027714 Exosc9 650 ENSMUSG00000027750.16 ENSMUSG00000027750 Postn 651 ENSMUSG00000027776.12 ENSMUSG00000027776 Il12a 652 ENSMUSG00000027777.15 ENSMUSG00000027777 Schip1 653 ENSMUSG00000027799.12 ENSMUSG00000027799 Nbea 654 ENSMUSG00000027808.8 ENSMUSG00000027808 Serp1 655 ENSMUSG00000027843.13 ENSMUSG00000027843 Ptpn22 656 ENSMUSG00000027863.8 ENSMUSG00000027863 Cd2 657 ENSMUSG00000027947.11 ENSMUSG00000027947 Il6ra 658 ENSMUSG00000027962.14 ENSMUSG00000027962 Vcam1 659 ENSMUSG00000027968.11 ENSMUSG00000027968 Larp7 660 ENSMUSG00000027983.13 ENSMUSG00000027983 Cyp2u1 661 ENSMUSG00000027995.10 ENSMUSG00000027995 Tlr2

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

662 ENSMUSG00000028019.9 ENSMUSG00000028019 Pdgfc 663 ENSMUSG00000028028.11 ENSMUSG00000028028 Alpk1 664 ENSMUSG00000028040.7 ENSMUSG00000028040 Efna4 665 ENSMUSG00000028042.15 ENSMUSG00000028042 Zbtb7b 666 ENSMUSG00000028064.17 ENSMUSG00000028064 Sema4a 667 ENSMUSG00000028066.15 ENSMUSG00000028066 Pmf1 668 ENSMUSG00000028071.12 ENSMUSG00000028071 Sh2d2a 669 ENSMUSG00000028078.14 ENSMUSG00000028078 Dclk2 670 ENSMUSG00000028081.6 ENSMUSG00000028081 Rps3a1 671 ENSMUSG00000028086.15 ENSMUSG00000028086 Fbxw7 672 ENSMUSG00000028121.8 ENSMUSG00000028121 Bcar3 673 ENSMUSG00000028132.15 ENSMUSG00000028132 Tmem56 674 ENSMUSG00000028211.11 ENSMUSG00000028211 Trp53inp1 675 ENSMUSG00000028218.19 ENSMUSG00000028218 Fam92a 676 ENSMUSG00000028226.15 ENSMUSG00000028226 Mmp16 677 ENSMUSG00000028246.13 ENSMUSG00000028246 Faxc 678 ENSMUSG00000028251.5 ENSMUSG00000028251 Tstd3 679 ENSMUSG00000028268.14 ENSMUSG00000028268 Gbp3 680 ENSMUSG00000028273.15 ENSMUSG00000028273 Pdlim5 681 ENSMUSG00000028277.13 ENSMUSG00000028277 Ube2j1 682 ENSMUSG00000028278.14 ENSMUSG00000028278 Rragd 683 ENSMUSG00000028289.12 ENSMUSG00000028289 Epha7 684 ENSMUSG00000028327.14 ENSMUSG00000028327 Stra6l 685 ENSMUSG00000028347.14 ENSMUSG00000028347 Tmeff1 686 ENSMUSG00000028362.2 ENSMUSG00000028362 Tnfsf8 687 ENSMUSG00000028381.8 ENSMUSG00000028381 Ugcg 688 ENSMUSG00000028392.15 ENSMUSG00000028392 Bspry 689 ENSMUSG00000028393.10 ENSMUSG00000028393 Alad 690 ENSMUSG00000028412.17 ENSMUSG00000028412 Slc44a1 691 ENSMUSG00000028420.13 ENSMUSG00000028420 Tmem38b 692 ENSMUSG00000028456.18 ENSMUSG00000028456 Unc13b 693 ENSMUSG00000028464.16 ENSMUSG00000028464 Tpm2 694 ENSMUSG00000028479.18 ENSMUSG00000028479 Gne 695 ENSMUSG00000028524.21 ENSMUSG00000028524 Sgip1 696 ENSMUSG00000028549.17 ENSMUSG00000028549 Itgb3bp 697 ENSMUSG00000028551.14 ENSMUSG00000028551 Cdkn2c 698 ENSMUSG00000028619.15 ENSMUSG00000028619 Tceanc2 699 ENSMUSG00000028634.17 ENSMUSG00000028634 Hivep3 700 ENSMUSG00000028644.16 ENSMUSG00000028644 Ermap 701 ENSMUSG00000028648.13 ENSMUSG00000028648 Ndufs5 702 ENSMUSG00000028651.12 ENSMUSG00000028651 Ppie 703 ENSMUSG00000028664.14 ENSMUSG00000028664 Ephb2 704 ENSMUSG00000028677.19 ENSMUSG00000028677 Rnf220 705 ENSMUSG00000028689.14 ENSMUSG00000028689 Ccdc163 706 ENSMUSG00000028691.12 ENSMUSG00000028691 Prdx1 707 ENSMUSG00000028708.16 ENSMUSG00000028708 Mknk1 708 ENSMUSG00000028763.17 ENSMUSG00000028763 Hspg2 709 ENSMUSG00000028766.10 ENSMUSG00000028766 Alpl 710 ENSMUSG00000028777.8 ENSMUSG00000028777 Gnat3 711 ENSMUSG00000028782.14 ENSMUSG00000028782 Adgrb2 712 ENSMUSG00000028795.15 ENSMUSG00000028795 Ccdc28b

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

713 ENSMUSG00000028801.14 ENSMUSG00000028801 Stpg1 714 ENSMUSG00000028832.11 ENSMUSG00000028832 Stmn1 715 ENSMUSG00000028838.11 ENSMUSG00000028838 Extl1 716 ENSMUSG00000028865.14 ENSMUSG00000028865 Cd164l2 717 ENSMUSG00000028874.14 ENSMUSG00000028874 Fgr 718 ENSMUSG00000028885.8 ENSMUSG00000028885 Smpdl3b 719 ENSMUSG00000028909.17 ENSMUSG00000028909 Ptpru 720 ENSMUSG00000028910.12 ENSMUSG00000028910 Mecr 721 ENSMUSG00000028927.6 ENSMUSG00000028927 Padi2 722 ENSMUSG00000028944.14 ENSMUSG00000028944 Prkag2 723 ENSMUSG00000028964.14 ENSMUSG00000028964 Park7 724 ENSMUSG00000028965.13 ENSMUSG00000028965 Tnfrsf9 725 ENSMUSG00000028967.10 ENSMUSG00000028967 Errfi1 726 ENSMUSG00000028971.4 ENSMUSG00000028971 Cort 727 ENSMUSG00000028973.18 ENSMUSG00000028973 Abcb8 728 ENSMUSG00000028979.17 ENSMUSG00000028979 Masp2 729 ENSMUSG00000028989.3 ENSMUSG00000028989 Angptl7 730 ENSMUSG00000028999.15 ENSMUSG00000028999 Rint1 731 ENSMUSG00000029001.15 ENSMUSG00000029001 Fbxo44 732 ENSMUSG00000029005.4 ENSMUSG00000029005 Draxin 733 ENSMUSG00000029007.8 ENSMUSG00000029007 Agtrap 734 ENSMUSG00000029016.13 ENSMUSG00000029016 Clcn6 735 ENSMUSG00000029022.18 ENSMUSG00000029022 Miip 736 ENSMUSG00000029054.8 ENSMUSG00000029054 Gabrd 737 ENSMUSG00000029084.5 ENSMUSG00000029084 Cd38 738 ENSMUSG00000029089.8 ENSMUSG00000029089 5730480H06Rik 739 ENSMUSG00000029093.14 ENSMUSG00000029093 Sorcs2 740 ENSMUSG00000029095.17 ENSMUSG00000029095 Ablim2 741 ENSMUSG00000029096.15 ENSMUSG00000029096 Htra3 742 ENSMUSG00000029119.9 ENSMUSG00000029119 Man2b2 743 ENSMUSG00000029120.10 ENSMUSG00000029120 Ppp2r2c 744 ENSMUSG00000029122.11 ENSMUSG00000029122 Evc 745 ENSMUSG00000029166.14 ENSMUSG00000029166 Mapre3 746 ENSMUSG00000029167.13 ENSMUSG00000029167 Ppargc1a 747 ENSMUSG00000029168.14 ENSMUSG00000029168 Dpysl5 748 ENSMUSG00000029196.9 ENSMUSG00000029196 Tada2b 749 ENSMUSG00000029211.11 ENSMUSG00000029211 Gabra4 750 ENSMUSG00000029223.12 ENSMUSG00000029223 Uchl1 751 ENSMUSG00000029245.16 ENSMUSG00000029245 Epha5 752 ENSMUSG00000029254.16 ENSMUSG00000029254 Stap1 753 ENSMUSG00000029290.12 ENSMUSG00000029290 Zfp326 754 ENSMUSG00000029298.15 ENSMUSG00000029298 Gbp9 755 ENSMUSG00000029314.14 ENSMUSG00000029314 Gpat3 756 ENSMUSG00000029343.17 ENSMUSG00000029343 Crybb1 757 ENSMUSG00000029369.17 ENSMUSG00000029369 Afm 758 ENSMUSG00000029380.11 ENSMUSG00000029380 Cxcl1 759 ENSMUSG00000029403.14 ENSMUSG00000029403 Cdkl2 760 ENSMUSG00000029407.10 ENSMUSG00000029407 Uso1 761 ENSMUSG00000029469.14 ENSMUSG00000029469 Ift81 762 ENSMUSG00000029503.16 ENSMUSG00000029503 P2rx2 763 ENSMUSG00000029552.19 ENSMUSG00000029552 Tes

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

764 ENSMUSG00000029563.16 ENSMUSG00000029563 Foxp2 765 ENSMUSG00000029570.5 ENSMUSG00000029570 Lfng 766 ENSMUSG00000029629.17 ENSMUSG00000029629 Phf14 767 ENSMUSG00000029632.7 ENSMUSG00000029632 Ndufa4 768 ENSMUSG00000029633.9 ENSMUSG00000029633 Gm5578 769 ENSMUSG00000029638.17 ENSMUSG00000029638 Glcci1 770 ENSMUSG00000029650.10 ENSMUSG00000029650 Slc46a3 771 ENSMUSG00000029657.15 ENSMUSG00000029657 Hsph1 772 ENSMUSG00000029658.17 ENSMUSG00000029658 Wdr95 773 ENSMUSG00000029661.16 ENSMUSG00000029661 Col1a2 774 ENSMUSG00000029676.15 ENSMUSG00000029676 Pot1a 775 ENSMUSG00000029710.15 ENSMUSG00000029710 Ephb4 776 ENSMUSG00000029716.13 ENSMUSG00000029716 Tfr2 777 ENSMUSG00000029718.14 ENSMUSG00000029718 Pcolce 778 ENSMUSG00000029752.12 ENSMUSG00000029752 Asns 779 ENSMUSG00000029759.9 ENSMUSG00000029759 Pon3 780 ENSMUSG00000029797.13 ENSMUSG00000029797 Sspo 781 ENSMUSG00000029798.11 ENSMUSG00000029798 Herc6 782 ENSMUSG00000029816.10 ENSMUSG00000029816 Gpnmb 783 ENSMUSG00000029924.12 ENSMUSG00000029924 Slc37a3 784 ENSMUSG00000029992.14 ENSMUSG00000029992 Gfpt1 785 ENSMUSG00000029993.16 ENSMUSG00000029993 Nfu1 786 ENSMUSG00000030048.5 ENSMUSG00000030048 Gkn3 787 ENSMUSG00000030077.11 ENSMUSG00000030077 Chl1 788 ENSMUSG00000030082.14 ENSMUSG00000030082 Sec61a1 789 ENSMUSG00000030084.11 ENSMUSG00000030084 Plxna1 790 ENSMUSG00000030086.16 ENSMUSG00000030086 Chchd6 791 ENSMUSG00000030088.15 ENSMUSG00000030088 Aldh1l1 792 ENSMUSG00000030103.11 ENSMUSG00000030103 Bhlhe40 793 ENSMUSG00000030104.9 ENSMUSG00000030104 Edem1 794 ENSMUSG00000030134.11 ENSMUSG00000030134 Rasgef1a 795 ENSMUSG00000030149.15 ENSMUSG00000030149 Klrk1 796 ENSMUSG00000030154.10 ENSMUSG00000030154 Klrb1f 797 ENSMUSG00000030165.16 ENSMUSG00000030165 Klrd1 798 ENSMUSG00000030167.15 ENSMUSG00000030167 Klrc1 799 ENSMUSG00000030170.14 ENSMUSG00000030170 Wnt5b 800 ENSMUSG00000030173.15 ENSMUSG00000030173 Klra5 801 ENSMUSG00000030178.15 ENSMUSG00000030178 Klra13-ps 802 ENSMUSG00000030188.12 ENSMUSG00000030188 Magohb 803 ENSMUSG00000030247.9 ENSMUSG00000030247 Kcnj8 804 ENSMUSG00000030249.15 ENSMUSG00000030249 Abcc9 805 ENSMUSG00000030256.11 ENSMUSG00000030256 Bhlhe41 806 ENSMUSG00000030259.12 ENSMUSG00000030259 Rassf8 807 ENSMUSG00000030268.17 ENSMUSG00000030268 Bcat1 808 ENSMUSG00000030283.7 ENSMUSG00000030283 St8sia1 809 ENSMUSG00000030287.15 ENSMUSG00000030287 Itpr2 810 ENSMUSG00000030302.16 ENSMUSG00000030302 Atp2b2 811 ENSMUSG00000030306.14 ENSMUSG00000030306 Tmtc1 812 ENSMUSG00000030310.10 ENSMUSG00000030310 Slc6a1 813 ENSMUSG00000030313.15 ENSMUSG00000030313 Dennd5b 814 ENSMUSG00000030325.16 ENSMUSG00000030325 Klrb1c

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

815 ENSMUSG00000030329.11 ENSMUSG00000030329 Pianp 816 ENSMUSG00000030336.14 ENSMUSG00000030336 Cd27 817 ENSMUSG00000030361.16 ENSMUSG00000030361 Klrb1a 818 ENSMUSG00000030365.11 ENSMUSG00000030365 Clec2i 819 ENSMUSG00000030409.15 ENSMUSG00000030409 Dmpk 820 ENSMUSG00000030423.7 ENSMUSG00000030423 Pop4 821 ENSMUSG00000030427.17 ENSMUSG00000030427 Lilra6 822 ENSMUSG00000030470.15 ENSMUSG00000030470 Csrp3 823 ENSMUSG00000030494.13 ENSMUSG00000030494 Rhpn2 824 ENSMUSG00000030505.17 ENSMUSG00000030505 Prmt3 825 ENSMUSG00000030519.14 ENSMUSG00000030519 Apba2 826 ENSMUSG00000030532.6 ENSMUSG00000030532 Hddc3 827 ENSMUSG00000030539.13 ENSMUSG00000030539 Sema4b 828 ENSMUSG00000030555.16 ENSMUSG00000030555 Ttc23 829 ENSMUSG00000030605.15 ENSMUSG00000030605 Mfge8 830 ENSMUSG00000030616.15 ENSMUSG00000030616 Sytl2 831 ENSMUSG00000030638.13 ENSMUSG00000030638 Sh3gl3 832 ENSMUSG00000030643.14 ENSMUSG00000030643 Rab30 833 ENSMUSG00000030651.5 ENSMUSG00000030651 Art2b 834 ENSMUSG00000030670.16 ENSMUSG00000030670 Cyp2r1 835 ENSMUSG00000030671.9 ENSMUSG00000030671 Pde3b 836 ENSMUSG00000030691.15 ENSMUSG00000030691 Fchsd2 837 ENSMUSG00000030706.17 ENSMUSG00000030706 Mrpl48 838 ENSMUSG00000030739.18 ENSMUSG00000030739 Myh14 839 ENSMUSG00000030750.13 ENSMUSG00000030750 Nsmce1 840 ENSMUSG00000030789.9 ENSMUSG00000030789 Itgax 841 ENSMUSG00000030792.8 ENSMUSG00000030792 Dkkl1 842 ENSMUSG00000030793.4 ENSMUSG00000030793 Pycard 843 ENSMUSG00000030825.19 ENSMUSG00000030825 Hsd17b14 844 ENSMUSG00000030827.5 ENSMUSG00000030827 Fgf21 845 ENSMUSG00000030830.18 ENSMUSG00000030830 Itgal 846 ENSMUSG00000031074.14 ENSMUSG00000031074 Fgf3 847 ENSMUSG00000031119.4 ENSMUSG00000031119 Gpc4 848 ENSMUSG00000031138.4 ENSMUSG00000031138 F9 849 ENSMUSG00000031139.15 ENSMUSG00000031139 Mcf2 850 ENSMUSG00000031202.5 ENSMUSG00000031202 Rab39b 851 ENSMUSG00000031257.14 ENSMUSG00000031257 Nox1 852 ENSMUSG00000031258.4 ENSMUSG00000031258 Xkrx 853 ENSMUSG00000031297.14 ENSMUSG00000031297 Slc7a3 854 ENSMUSG00000031375.17 ENSMUSG00000031375 Bgn 855 ENSMUSG00000031391.18 ENSMUSG00000031391 L1cam 856 ENSMUSG00000031428.11 ENSMUSG00000031428 Zcchc18 857 ENSMUSG00000031431.13 ENSMUSG00000031431 Tsc22d3 858 ENSMUSG00000031441.15 ENSMUSG00000031441 Atp11a 859 ENSMUSG00000031442.20 ENSMUSG00000031442 Mcf2l 860 ENSMUSG00000031444.16 ENSMUSG00000031444 F10 861 ENSMUSG00000031448.12 ENSMUSG00000031448 Adprhl1 862 ENSMUSG00000031461.4 ENSMUSG00000031461 Myom2 863 ENSMUSG00000031465.6 ENSMUSG00000031465 Angpt2 864 ENSMUSG00000031467.10 ENSMUSG00000031467 Agpat5 865 ENSMUSG00000031486.15 ENSMUSG00000031486 Adgra2

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

866 ENSMUSG00000031488.14 ENSMUSG00000031488 Rab11fip1 867 ENSMUSG00000031493.10 ENSMUSG00000031493 Ggn 868 ENSMUSG00000031502.11 ENSMUSG00000031502 Col4a1 869 ENSMUSG00000031503.13 ENSMUSG00000031503 Col4a2 870 ENSMUSG00000031517.8 ENSMUSG00000031517 Gpm6a 871 ENSMUSG00000031543.18 ENSMUSG00000031543 Ank1 872 ENSMUSG00000031554.18 ENSMUSG00000031554 Adam5 873 ENSMUSG00000031558.15 ENSMUSG00000031558 Slit2 874 ENSMUSG00000031570.17 ENSMUSG00000031570 Plpp5 875 ENSMUSG00000031586.17 ENSMUSG00000031586 Rbpms 876 ENSMUSG00000031595.9 ENSMUSG00000031595 Pdgfrl 877 ENSMUSG00000031600.10 ENSMUSG00000031600 Vps37a 878 ENSMUSG00000031636.7 ENSMUSG00000031636 Pdlim3 879 ENSMUSG00000031667.16 ENSMUSG00000031667 Aktip 880 ENSMUSG00000031668.14 ENSMUSG00000031668 Eif2ak3 881 ENSMUSG00000031673.6 ENSMUSG00000031673 Cdh11 882 ENSMUSG00000031697.12 ENSMUSG00000031697 Orc6 883 ENSMUSG00000031698.14 ENSMUSG00000031698 Mylk3 884 ENSMUSG00000031712.10 ENSMUSG00000031712 Il15 885 ENSMUSG00000031736.11 ENSMUSG00000031736 Crnde 886 ENSMUSG00000031756.5 ENSMUSG00000031756 Cenpn 887 ENSMUSG00000031762.7 ENSMUSG00000031762 Mt2 888 ENSMUSG00000031765.8 ENSMUSG00000031765 Mt1 889 ENSMUSG00000031767.13 ENSMUSG00000031767 Nudt7 890 ENSMUSG00000031770.16 ENSMUSG00000031770 Herpud1 891 ENSMUSG00000031781.14 ENSMUSG00000031781 Ciapin1 892 ENSMUSG00000031786.7 ENSMUSG00000031786 Drc7 893 ENSMUSG00000031788.14 ENSMUSG00000031788 Kifc3 894 ENSMUSG00000031789.17 ENSMUSG00000031789 Cngb1 895 ENSMUSG00000031803.8 ENSMUSG00000031803 B3gnt3 896 ENSMUSG00000031824.15 ENSMUSG00000031824 6430548M08Rik 897 ENSMUSG00000031840.12 ENSMUSG00000031840 Rab3a 898 ENSMUSG00000031848.15 ENSMUSG00000031848 Lsm4 899 ENSMUSG00000031849.9 ENSMUSG00000031849 Comp 900 ENSMUSG00000031851.14 ENSMUSG00000031851 Ntpcr 901 ENSMUSG00000031860.17 ENSMUSG00000031860 Pbx4 902 ENSMUSG00000031861.15 ENSMUSG00000031861 Lpar2 903 ENSMUSG00000031871.9 ENSMUSG00000031871 Cdh5 904 ENSMUSG00000031877.9 ENSMUSG00000031877 Ces2g 905 ENSMUSG00000031933.17 ENSMUSG00000031933 Izumo1r 906 ENSMUSG00000031955.10 ENSMUSG00000031955 Bcar1 907 ENSMUSG00000032021.14 ENSMUSG00000032021 Crtam 908 ENSMUSG00000032023.7 ENSMUSG00000032023 Jhy 909 ENSMUSG00000032026.7 ENSMUSG00000032026 Rexo2 910 ENSMUSG00000032035.15 ENSMUSG00000032035 Ets1 911 ENSMUSG00000032041.15 ENSMUSG00000032041 Tirap 912 ENSMUSG00000032042.11 ENSMUSG00000032042 Srpr 913 ENSMUSG00000032053.8 ENSMUSG00000032053 Pou2af1 914 ENSMUSG00000032076.19 ENSMUSG00000032076 Cadm1 915 ENSMUSG00000032089.16 ENSMUSG00000032089 Il10ra 916 ENSMUSG00000032093.7 ENSMUSG00000032093 Cd3e

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

917 ENSMUSG00000032094.8 ENSMUSG00000032094 Cd3d 918 ENSMUSG00000032115.14 ENSMUSG00000032115 Hyou1 919 ENSMUSG00000032120.11 ENSMUSG00000032120 C2cd2l 920 ENSMUSG00000032131.16 ENSMUSG00000032131 Abcg4 921 ENSMUSG00000032182.15 ENSMUSG00000032182 Yipf2 922 ENSMUSG00000032193.9 ENSMUSG00000032193 Ldlr 923 ENSMUSG00000032207.10 ENSMUSG00000032207 Lipc 924 ENSMUSG00000032218.7 ENSMUSG00000032218 Ccnb2 925 ENSMUSG00000032221.14 ENSMUSG00000032221 Mns1 926 ENSMUSG00000032239.10 ENSMUSG00000032239 Rp9 927 ENSMUSG00000032278.11 ENSMUSG00000032278 Paqr5 928 ENSMUSG00000032323.13 ENSMUSG00000032323 Cyp11a1 929 ENSMUSG00000032332.17 ENSMUSG00000032332 Col12a1 930 ENSMUSG00000032336.17 ENSMUSG00000032336 Nptn 931 ENSMUSG00000032340.8 ENSMUSG00000032340 Neo1 932 ENSMUSG00000032352.16 ENSMUSG00000032352 Lrrc1 933 ENSMUSG00000032380.8 ENSMUSG00000032380 Dapk2 934 ENSMUSG00000032413.12 ENSMUSG00000032413 Rasa2 935 ENSMUSG00000032425.15 ENSMUSG00000032425 Zfp949 936 ENSMUSG00000032436.17 ENSMUSG00000032436 Cmtm7 937 ENSMUSG00000032446.14 ENSMUSG00000032446 Eomes 938 ENSMUSG00000032456.13 ENSMUSG00000032456 Nmnat3 939 ENSMUSG00000032492.14 ENSMUSG00000032492 Pth1r 940 ENSMUSG00000032501.9 ENSMUSG00000032501 Trib1 941 ENSMUSG00000032503.18 ENSMUSG00000032503 Arpp21 942 ENSMUSG00000032547.12 ENSMUSG00000032547 Ryk 943 ENSMUSG00000032549.7 ENSMUSG00000032549 Rab6b 944 ENSMUSG00000032557.13 ENSMUSG00000032557 Uba5 945 ENSMUSG00000032561.15 ENSMUSG00000032561 Acpp 946 ENSMUSG00000032564.16 ENSMUSG00000032564 Cpne4 947 ENSMUSG00000032572.9 ENSMUSG00000032572 Col6a4 948 ENSMUSG00000032575.16 ENSMUSG00000032575 Manf 949 ENSMUSG00000032601.13 ENSMUSG00000032601 Prkar2a 950 ENSMUSG00000032625.14 ENSMUSG00000032625 Thsd7a 951 ENSMUSG00000032649.14 ENSMUSG00000032649 Colgalt2 952 ENSMUSG00000032652.13 ENSMUSG00000032652 Crebl2 953 ENSMUSG00000032666.16 ENSMUSG00000032666 1700025G04Rik 954 ENSMUSG00000032667.17 ENSMUSG00000032667 Pon2 955 ENSMUSG00000032702.16 ENSMUSG00000032702 Kank1 956 ENSMUSG00000032717.14 ENSMUSG00000032717 Mdfi 957 ENSMUSG00000032719.4 ENSMUSG00000032719 Sbspon 958 ENSMUSG00000032737.13 ENSMUSG00000032737 Inppl1 959 ENSMUSG00000032841.15 ENSMUSG00000032841 Prr5l 960 ENSMUSG00000032845.15 ENSMUSG00000032845 Alpk2 961 ENSMUSG00000032854.12 ENSMUSG00000032854 Ugt8a 962 ENSMUSG00000032864.4 ENSMUSG00000032864 Rag2 963 ENSMUSG00000032883.15 ENSMUSG00000032883 Acsl3 964 ENSMUSG00000032889.6 ENSMUSG00000032889 Gm6685 965 ENSMUSG00000032890.17 ENSMUSG00000032890 Rims3 966 ENSMUSG00000032915.6 ENSMUSG00000032915 Adgre4 967 ENSMUSG00000032932.15 ENSMUSG00000032932 Hspa13

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

968 ENSMUSG00000032966.14 ENSMUSG00000032966 Fkbp1a 969 ENSMUSG00000032997.16 ENSMUSG00000032997 Chpf 970 ENSMUSG00000033024.16 ENSMUSG00000033024 Klra9 971 ENSMUSG00000033027.15 ENSMUSG00000033027 Klrc3 972 ENSMUSG00000033060.15 ENSMUSG00000033060 Lmo7 973 ENSMUSG00000033066.15 ENSMUSG00000033066 Gas7 974 ENSMUSG00000033102.15 ENSMUSG00000033102 Cdc14b 975 ENSMUSG00000033147.16 ENSMUSG00000033147 Slc22a15 976 ENSMUSG00000033174.17 ENSMUSG00000033174 Mgll 977 ENSMUSG00000033182.12 ENSMUSG00000033182 Kbtbd12 978 ENSMUSG00000033210.16 ENSMUSG00000033210 Slc9c1 979 ENSMUSG00000033249.10 ENSMUSG00000033249 Hsf4 980 ENSMUSG00000033278.10 ENSMUSG00000033278 Ptprm 981 ENSMUSG00000033295.14 ENSMUSG00000033295 Ptprf 982 ENSMUSG00000033327.16 ENSMUSG00000033327 Tnxb 983 ENSMUSG00000033350.7 ENSMUSG00000033350 Chst2 984 ENSMUSG00000033355.6 ENSMUSG00000033355 Rtp4 985 ENSMUSG00000033377.14 ENSMUSG00000033377 Palmd 986 ENSMUSG00000033400.14 ENSMUSG00000033400 Agl 987 ENSMUSG00000033467.12 ENSMUSG00000033467 Crlf2 988 ENSMUSG00000033488.11 ENSMUSG00000033488 Cryzl2 989 ENSMUSG00000033540.18 ENSMUSG00000033540 Idua 990 ENSMUSG00000033554.17 ENSMUSG00000033554 Dph5 991 ENSMUSG00000033618.7 ENSMUSG00000033618 Map3k13 992 ENSMUSG00000033634.7 ENSMUSG00000033634 Nat8f2 993 ENSMUSG00000033788.15 ENSMUSG00000033788 Dysf 994 ENSMUSG00000033825.9 ENSMUSG00000033825 Tpsb2 995 ENSMUSG00000033826.9 ENSMUSG00000033826 Dnah8 996 ENSMUSG00000033882.15 ENSMUSG00000033882 Rbm46 997 ENSMUSG00000034028.15 ENSMUSG00000034028 Cd226 998 ENSMUSG00000034066.13 ENSMUSG00000034066 Farp2 999 ENSMUSG00000034118.15 ENSMUSG00000034118 Tpst1 1000 ENSMUSG00000034168.7 ENSMUSG00000034168 Irf2bpl 1001 ENSMUSG00000034177.15 ENSMUSG00000034177 Rnf43 1002 ENSMUSG00000034192.5 ENSMUSG00000034192 Lsm3 1003 ENSMUSG00000034329.16 ENSMUSG00000034329 Brip1 1004 ENSMUSG00000034353.14 ENSMUSG00000034353 Ramp1 1005 ENSMUSG00000034361.10 ENSMUSG00000034361 Cpne2 1006 ENSMUSG00000034377.10 ENSMUSG00000034377 Tulp4 1007 ENSMUSG00000034424.5 ENSMUSG00000034424 Gcsh 1008 ENSMUSG00000034460.9 ENSMUSG00000034460 Six4 1009 ENSMUSG00000034471.12 ENSMUSG00000034471 Caskin2 1010 ENSMUSG00000034557.14 ENSMUSG00000034557 Zfyve9 1011 ENSMUSG00000034574.10 ENSMUSG00000034574 Daam1 1012 ENSMUSG00000034586.14 ENSMUSG00000034586 Hid1 1013 ENSMUSG00000034587.8 ENSMUSG00000034587 8430429K09Rik 1014 ENSMUSG00000034591.5 ENSMUSG00000034591 Slc41a2 1015 ENSMUSG00000034634.7 ENSMUSG00000034634 Ly6d 1016 ENSMUSG00000034664.13 ENSMUSG00000034664 Itga2b 1017 ENSMUSG00000034674.18 ENSMUSG00000034674 Tdg 1018 ENSMUSG00000034681.16 ENSMUSG00000034681 Rnps1

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1019 ENSMUSG00000034684.12 ENSMUSG00000034684 Sema3f 1020 ENSMUSG00000034687.8 ENSMUSG00000034687 Fras1 1021 ENSMUSG00000034708.11 ENSMUSG00000034708 Grn 1022 ENSMUSG00000034731.10 ENSMUSG00000034731 Dgkh 1023 ENSMUSG00000034773.16 ENSMUSG00000034773 BC030867 1024 ENSMUSG00000034783.7 ENSMUSG00000034783 Cd207 1025 ENSMUSG00000034795.14 ENSMUSG00000034795 Ccdc122 1026 ENSMUSG00000034796.14 ENSMUSG00000034796 Cpne7 1027 ENSMUSG00000034833.10 ENSMUSG00000034833 Tespa1 1028 ENSMUSG00000034858.16 ENSMUSG00000034858 Fam214a 1029 ENSMUSG00000034881.8 ENSMUSG00000034881 Tbxa2r 1030 ENSMUSG00000034898.16 ENSMUSG00000034898 Filip1 1031 ENSMUSG00000034926.3 ENSMUSG00000034926 Dhcr24 1032 ENSMUSG00000034936.2 ENSMUSG00000034936 Arl4d 1033 ENSMUSG00000034957.10 ENSMUSG00000034957 Cebpa 1034 ENSMUSG00000034981.9 ENSMUSG00000034981 Parm1 1035 ENSMUSG00000035042.2 ENSMUSG00000035042 Ccl5 1036 ENSMUSG00000035104.14 ENSMUSG00000035104 Eva1a 1037 ENSMUSG00000035105.5 ENSMUSG00000035105 Egln3 1038 ENSMUSG00000035126.19 ENSMUSG00000035126 Wdr78 1039 ENSMUSG00000035172.15 ENSMUSG00000035172 Plekhh3 1040 ENSMUSG00000035173.14 ENSMUSG00000035173 Ccdc186 1041 ENSMUSG00000035184.15 ENSMUSG00000035184 Fam124a 1042 ENSMUSG00000035208.16 ENSMUSG00000035208 Slfn8 1043 ENSMUSG00000035273.14 ENSMUSG00000035273 Hpse 1044 ENSMUSG00000035283.4 ENSMUSG00000035283 Adrb1 1045 ENSMUSG00000035299.16 ENSMUSG00000035299 Mid1 1046 ENSMUSG00000035357.16 ENSMUSG00000035357 Pdzrn3 1047 ENSMUSG00000035413.8 ENSMUSG00000035413 Tmem98 1048 ENSMUSG00000035435.16 ENSMUSG00000035435 Abca17 1049 ENSMUSG00000035448.9 ENSMUSG00000035448 Ccr3 1050 ENSMUSG00000035472.14 ENSMUSG00000035472 Slc25a21 1051 ENSMUSG00000035513.19 ENSMUSG00000035513 Ntng2 1052 ENSMUSG00000035580.10 ENSMUSG00000035580 Kcnh8 1053 ENSMUSG00000035638.14 ENSMUSG00000035638 Muc20 1054 ENSMUSG00000035642.16 ENSMUSG00000035642 Aamdc 1055 ENSMUSG00000035694.15 ENSMUSG00000035694 Caps2 1056 ENSMUSG00000035704.17 ENSMUSG00000035704 Alg8 1057 ENSMUSG00000035759.4 ENSMUSG00000035759 Bbs10 1058 ENSMUSG00000035775.2 ENSMUSG00000035775 Krt20 1059 ENSMUSG00000035835.14 ENSMUSG00000035835 Plppr3 1060 ENSMUSG00000035849.14 ENSMUSG00000035849 Krt222 1061 ENSMUSG00000035852.11 ENSMUSG00000035852 Misp 1062 ENSMUSG00000035873.8 ENSMUSG00000035873 Pawr 1063 ENSMUSG00000035944.17 ENSMUSG00000035944 Ttc38 1064 ENSMUSG00000035948.13 ENSMUSG00000035948 Acss3 1065 ENSMUSG00000035954.10 ENSMUSG00000035954 Dock4 1066 ENSMUSG00000035960.14 ENSMUSG00000035960 Apex1 1067 ENSMUSG00000036078.16 ENSMUSG00000036078 Sigmar1 1068 ENSMUSG00000036181.2 ENSMUSG00000036181 Hist1h1c 1069 ENSMUSG00000036185.9 ENSMUSG00000036185 Sapcd1

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1070 ENSMUSG00000036186.5 ENSMUSG00000036186 Fam69b 1071 ENSMUSG00000036225.14 ENSMUSG00000036225 Kctd1 1072 ENSMUSG00000036278.6 ENSMUSG00000036278 Macrod1 1073 ENSMUSG00000036295.5 ENSMUSG00000036295 Lrrn3 1074 ENSMUSG00000036322.10 ENSMUSG00000036322 H2-Ea-ps 1075 ENSMUSG00000036330.12 ENSMUSG00000036330 Slc18a1 1076 ENSMUSG00000036381.13 ENSMUSG00000036381 P2ry14 1077 ENSMUSG00000036391.16 ENSMUSG00000036391 Sec24a 1078 ENSMUSG00000036427.5 ENSMUSG00000036427 Gpi1 1079 ENSMUSG00000036502.14 ENSMUSG00000036502 Tmem255a 1080 ENSMUSG00000036526.8 ENSMUSG00000036526 Card11 1081 ENSMUSG00000036585.15 ENSMUSG00000036585 Fgf1 1082 ENSMUSG00000036587.13 ENSMUSG00000036587 Fut7 1083 ENSMUSG00000036617.16 ENSMUSG00000036617 Etl4 1084 ENSMUSG00000036634.15 ENSMUSG00000036634 Mag 1085 ENSMUSG00000036639.12 ENSMUSG00000036639 Nudt1 1086 ENSMUSG00000036646.13 ENSMUSG00000036646 Man1b1 1087 ENSMUSG00000036733.16 ENSMUSG00000036733 Rbm42 1088 ENSMUSG00000036748.15 ENSMUSG00000036748 Cuedc2 1089 ENSMUSG00000036820.11 ENSMUSG00000036820 Amdhd2 1090 ENSMUSG00000036887.5 ENSMUSG00000036887 C1qa 1091 ENSMUSG00000036896.5 ENSMUSG00000036896 C1qc 1092 ENSMUSG00000036905.8 ENSMUSG00000036905 C1qb 1093 ENSMUSG00000036995.7 ENSMUSG00000036995 Asap3 1094 ENSMUSG00000037031.10 ENSMUSG00000037031 Tspan15 1095 ENSMUSG00000037033.9 ENSMUSG00000037033 Clca3b 1096 ENSMUSG00000037035.5 ENSMUSG00000037035 Inhbb 1097 ENSMUSG00000037124.6 ENSMUSG00000037124 Trim58 1098 ENSMUSG00000037188.7 ENSMUSG00000037188 Grhl3 1099 ENSMUSG00000037202.6 ENSMUSG00000037202 Prf1 1100 ENSMUSG00000037221.13 ENSMUSG00000037221 Mospd3 1101 ENSMUSG00000037224.15 ENSMUSG00000037224 Zfyve28 1102 ENSMUSG00000037225.13 ENSMUSG00000037225 Fgf2 1103 ENSMUSG00000037259.15 ENSMUSG00000037259 Dzank1 1104 ENSMUSG00000037280.12 ENSMUSG00000037280 Galnt6 1105 ENSMUSG00000037306.13 ENSMUSG00000037306 Man1c1 1106 ENSMUSG00000037362.8 ENSMUSG00000037362 Nov 1107 ENSMUSG00000037370.13 ENSMUSG00000037370 Enpp1 1108 ENSMUSG00000037386.16 ENSMUSG00000037386 Rims2 1109 ENSMUSG00000037390.12 ENSMUSG00000037390 Muc3 1110 ENSMUSG00000037411.10 ENSMUSG00000037411 Serpine1 1111 ENSMUSG00000037461.10 ENSMUSG00000037461 Ints7 1112 ENSMUSG00000037492.16 ENSMUSG00000037492 Zmat4 1113 ENSMUSG00000037493.6 ENSMUSG00000037493 Cib2 1114 ENSMUSG00000037568.12 ENSMUSG00000037568 Vash2 1115 ENSMUSG00000037572.17 ENSMUSG00000037572 Wdhd1 1116 ENSMUSG00000037580.10 ENSMUSG00000037580 Gch1 1117 ENSMUSG00000037583.2 ENSMUSG00000037583 Nr0b2 1118 ENSMUSG00000037594.11 ENSMUSG00000037594 Clba1 1119 ENSMUSG00000037600.16 ENSMUSG00000037600 Kdf1 1120 ENSMUSG00000037610.15 ENSMUSG00000037610 Kcnmb2

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1121 ENSMUSG00000037621.8 ENSMUSG00000037621 Atoh8 1122 ENSMUSG00000037649.9 ENSMUSG00000037649 H2-DMa 1123 ENSMUSG00000037681.13 ENSMUSG00000037681 Esyt3 1124 ENSMUSG00000037683.14 ENSMUSG00000037683 Armc3 1125 ENSMUSG00000037708.16 ENSMUSG00000037708 Spag6 1126 ENSMUSG00000037725.8 ENSMUSG00000037725 Ckap2 1127 ENSMUSG00000037736.18 ENSMUSG00000037736 Limch1 1128 ENSMUSG00000037754.13 ENSMUSG00000037754 Ppp1r16b 1129 ENSMUSG00000037820.15 ENSMUSG00000037820 Tgm2 1130 ENSMUSG00000037902.18 ENSMUSG00000037902 Sirpa 1131 ENSMUSG00000037922.13 ENSMUSG00000037922 Bank1 1132 ENSMUSG00000037935.16 ENSMUSG00000037935 Smarce1 1133 ENSMUSG00000037979.13 ENSMUSG00000037979 Ccdc92 1134 ENSMUSG00000037991.9 ENSMUSG00000037991 Rmi2 1135 ENSMUSG00000037994.14 ENSMUSG00000037994 Slc9b2 1136 ENSMUSG00000038010.9 ENSMUSG00000038010 Ccdc138 1137 ENSMUSG00000038011.15 ENSMUSG00000038011 Dnah10 1138 ENSMUSG00000038020.5 ENSMUSG00000038020 Rapgefl1 1139 ENSMUSG00000038022.11 ENSMUSG00000038022 Mindy4 1140 ENSMUSG00000038037.5 ENSMUSG00000038037 Socs1 1141 ENSMUSG00000038058.14 ENSMUSG00000038058 Nod1 1142 ENSMUSG00000038059.6 ENSMUSG00000038059 Smim3 1143 ENSMUSG00000038074.16 ENSMUSG00000038074 Fkbp14 1144 ENSMUSG00000038128.6 ENSMUSG00000038128 Camk4 1145 ENSMUSG00000038143.16 ENSMUSG00000038143 Stox2 1146 ENSMUSG00000038151.13 ENSMUSG00000038151 Prdm1 1147 ENSMUSG00000038156.16 ENSMUSG00000038156 Spon1 1148 ENSMUSG00000038170.15 ENSMUSG00000038170 Pde4dip 1149 ENSMUSG00000038172.14 ENSMUSG00000038172 Ttc39b 1150 ENSMUSG00000038173.15 ENSMUSG00000038173 Enpp6 1151 ENSMUSG00000038179.13 ENSMUSG00000038179 Slamf7 1152 ENSMUSG00000038181.16 ENSMUSG00000038181 Chpf2 1153 ENSMUSG00000038209.12 ENSMUSG00000038209 Itln1 1154 ENSMUSG00000038213.7 ENSMUSG00000038213 Tapbpl 1155 ENSMUSG00000038218.3 ENSMUSG00000038218 Gm9765 1156 ENSMUSG00000038244.14 ENSMUSG00000038244 Mical2 1157 ENSMUSG00000038280.12 ENSMUSG00000038280 Ostm1 1158 ENSMUSG00000038301.15 ENSMUSG00000038301 Snx10 1159 ENSMUSG00000038304.14 ENSMUSG00000038304 Cd160 1160 ENSMUSG00000038312.10 ENSMUSG00000038312 Edem2 1161 ENSMUSG00000038319.14 ENSMUSG00000038319 Kcnh2 1162 ENSMUSG00000038354.13 ENSMUSG00000038354 Ankrd35 1163 ENSMUSG00000038370.6 ENSMUSG00000038370 Pcp4l1 1164 ENSMUSG00000038371.15 ENSMUSG00000038371 Sbf2 1165 ENSMUSG00000038375.15 ENSMUSG00000038375 Trp53inp2 1166 ENSMUSG00000038421.13 ENSMUSG00000038421 Fcrla 1167 ENSMUSG00000038425.17 ENSMUSG00000038425 Poli 1168 ENSMUSG00000038456.9 ENSMUSG00000038456 Dennd2a 1169 ENSMUSG00000038463.8 ENSMUSG00000038463 Olfml2b 1170 ENSMUSG00000038530.11 ENSMUSG00000038530 Rgs4 1171 ENSMUSG00000038630.8 ENSMUSG00000038630 Zkscan16

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1172 ENSMUSG00000038633.5 ENSMUSG00000038633 Degs1 1173 ENSMUSG00000038642.10 ENSMUSG00000038642 Ctss 1174 ENSMUSG00000038648.5 ENSMUSG00000038648 Creb3l2 1175 ENSMUSG00000038677.14 ENSMUSG00000038677 Scube3 1176 ENSMUSG00000038725.13 ENSMUSG00000038725 Pkhd1l1 1177 ENSMUSG00000038738.15 ENSMUSG00000038738 Shank1 1178 ENSMUSG00000038793.8 ENSMUSG00000038793 Lefty1 1179 ENSMUSG00000038797.13 ENSMUSG00000038797 Zscan2 1180 ENSMUSG00000038807.18 ENSMUSG00000038807 Rap1gap2 1181 ENSMUSG00000038828.13 ENSMUSG00000038828 Tmem214 1182 ENSMUSG00000038894.7 ENSMUSG00000038894 Irs2 1183 ENSMUSG00000038949.8 ENSMUSG00000038949 Cnst 1184 ENSMUSG00000038954.14 ENSMUSG00000038954 Supt3 1185 ENSMUSG00000038991.17 ENSMUSG00000038991 Txndc5 1186 ENSMUSG00000039004.6 ENSMUSG00000039004 Bmp6 1187 ENSMUSG00000039037.5 ENSMUSG00000039037 St6galnac5 1188 ENSMUSG00000039081.10 ENSMUSG00000039081 Zfp503 1189 ENSMUSG00000039109.16 ENSMUSG00000039109 F13a1 1190 ENSMUSG00000039167.11 ENSMUSG00000039167 Adgrl4 1191 ENSMUSG00000039191.12 ENSMUSG00000039191 Rbpj 1192 ENSMUSG00000039234.11 ENSMUSG00000039234 Sec24d 1193 ENSMUSG00000039239.14 ENSMUSG00000039239 Tgfb2 1194 ENSMUSG00000039269.5 ENSMUSG00000039269 2300002M23Rik 1195 ENSMUSG00000039270.9 ENSMUSG00000039270 Megf9 1196 ENSMUSG00000039286.12 ENSMUSG00000039286 Fndc3b 1197 ENSMUSG00000039315.15 ENSMUSG00000039315 Clnk 1198 ENSMUSG00000039395.8 ENSMUSG00000039395 Mreg 1199 ENSMUSG00000039457.4 ENSMUSG00000039457 Ppl 1200 ENSMUSG00000039474.13 ENSMUSG00000039474 Wfs1 1201 ENSMUSG00000039497.8 ENSMUSG00000039497 Dse 1202 ENSMUSG00000039512.12 ENSMUSG00000039512 Uhrf1bp1 1203 ENSMUSG00000039518.7 ENSMUSG00000039518 Cdsn 1204 ENSMUSG00000039578.17 ENSMUSG00000039578 Ccser1 1205 ENSMUSG00000039601.16 ENSMUSG00000039601 Rcan2 1206 ENSMUSG00000039629.14 ENSMUSG00000039629 Strip2 1207 ENSMUSG00000039652.16 ENSMUSG00000039652 Cpeb3 1208 ENSMUSG00000039706.11 ENSMUSG00000039706 Ldb2 1209 ENSMUSG00000039782.14 ENSMUSG00000039782 Cpeb2 1210 ENSMUSG00000039814.15 ENSMUSG00000039814 Xkr5 1211 ENSMUSG00000039851.11 ENSMUSG00000039851 4932438H23Rik 1212 ENSMUSG00000039908.14 ENSMUSG00000039908 Slc26a11 1213 ENSMUSG00000039934.12 ENSMUSG00000039934 Gsap 1214 ENSMUSG00000039963.18 ENSMUSG00000039963 Ccdc40 1215 ENSMUSG00000039981.6 ENSMUSG00000039981 Zc3h12d 1216 ENSMUSG00000039989.7 ENSMUSG00000039989 Cbx4 1217 ENSMUSG00000039994.15 ENSMUSG00000039994 Timeless 1218 ENSMUSG00000040035.14 ENSMUSG00000040035 Disp2 1219 ENSMUSG00000040037.13 ENSMUSG00000040037 Negr1 1220 ENSMUSG00000040093.15 ENSMUSG00000040093 Bmf 1221 ENSMUSG00000040147.14 ENSMUSG00000040147 Maob 1222 ENSMUSG00000040152.8 ENSMUSG00000040152 Thbs1

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1223 ENSMUSG00000040254.11 ENSMUSG00000040254 Sema3d 1224 ENSMUSG00000040264.10 ENSMUSG00000040264 Gbp2b 1225 ENSMUSG00000040268.17 ENSMUSG00000040268 Plekha1 1226 ENSMUSG00000040272.14 ENSMUSG00000040272 Accs 1227 ENSMUSG00000040280.10 ENSMUSG00000040280 Ndufa4l2 1228 ENSMUSG00000040287.9 ENSMUSG00000040287 Stac3 1229 ENSMUSG00000040310.12 ENSMUSG00000040310 Alx4 1230 ENSMUSG00000040312.14 ENSMUSG00000040312 Cchcr1 1231 ENSMUSG00000040314.2 ENSMUSG00000040314 Ctsg 1232 ENSMUSG00000040328.15 ENSMUSG00000040328 Olfr56 1233 ENSMUSG00000040340.13 ENSMUSG00000040340 Tex45 1234 ENSMUSG00000040359.14 ENSMUSG00000040359 Ufl1 1235 ENSMUSG00000040372.2 ENSMUSG00000040372 Gpr63 1236 ENSMUSG00000040387.16 ENSMUSG00000040387 Klhl32 1237 ENSMUSG00000040471.17 ENSMUSG00000040471 Ggt6 1238 ENSMUSG00000040488.17 ENSMUSG00000040488 Ltbp4 1239 ENSMUSG00000040502.5 ENSMUSG00000040502 43533 1240 ENSMUSG00000040522.5 ENSMUSG00000040522 Tlr8 1241 ENSMUSG00000040591.18 ENSMUSG00000040591 1110051M20Rik 1242 ENSMUSG00000040592.11 ENSMUSG00000040592 Cd79b 1243 ENSMUSG00000040624.17 ENSMUSG00000040624 Plekhg1 1244 ENSMUSG00000040658.7 ENSMUSG00000040658 Dnph1 1245 ENSMUSG00000040717.6 ENSMUSG00000040717 Il17rd 1246 ENSMUSG00000040732.20 ENSMUSG00000040732 Erg 1247 ENSMUSG00000040809.10 ENSMUSG00000040809 Chil3 1248 ENSMUSG00000040812.14 ENSMUSG00000040812 Agbl2 1249 ENSMUSG00000040855.15 ENSMUSG00000040855 Reps2 1250 ENSMUSG00000040860.16 ENSMUSG00000040860 Crocc 1251 ENSMUSG00000040896.16 ENSMUSG00000040896 Kcnd3 1252 ENSMUSG00000040899.14 ENSMUSG00000040899 Ccr6 1253 ENSMUSG00000041126.16 ENSMUSG00000041126 H2afv 1254 ENSMUSG00000041165.6 ENSMUSG00000041165 Spem1 1255 ENSMUSG00000041202.12 ENSMUSG00000041202 Pla2g2d 1256 ENSMUSG00000041235.12 ENSMUSG00000041235 Chd7 1257 ENSMUSG00000041301.15 ENSMUSG00000041301 Cftr 1258 ENSMUSG00000041309.17 ENSMUSG00000041309 Nkx6-2 1259 ENSMUSG00000041329.13 ENSMUSG00000041329 Atp1b2 1260 ENSMUSG00000041347.5 ENSMUSG00000041347 Bdkrb1 1261 ENSMUSG00000041351.16 ENSMUSG00000041351 Rap1gap 1262 ENSMUSG00000041360.7 ENSMUSG00000041360 Pum3 1263 ENSMUSG00000041361.13 ENSMUSG00000041361 Myzap 1264 ENSMUSG00000041440.18 ENSMUSG00000041440 Gk5 1265 ENSMUSG00000041444.14 ENSMUSG00000041444 Arhgap32 1266 ENSMUSG00000041453.12 ENSMUSG00000041453 Rpl21 1267 ENSMUSG00000041538.15 ENSMUSG00000041538 H2-Ob 1268 ENSMUSG00000041570.14 ENSMUSG00000041570 Camsap2 1269 ENSMUSG00000041596.12 ENSMUSG00000041596 Nlrp5-ps 1270 ENSMUSG00000041729.15 ENSMUSG00000041729 Coro2b 1271 ENSMUSG00000041734.15 ENSMUSG00000041734 Kirrel 1272 ENSMUSG00000041750.13 ENSMUSG00000041750 Cd1d2 1273 ENSMUSG00000041762.16 ENSMUSG00000041762 Gpr155

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1274 ENSMUSG00000041779.5 ENSMUSG00000041779 Tram2 1275 ENSMUSG00000041789.7 ENSMUSG00000041789 2700046A07Rik 1276 ENSMUSG00000041797.7 ENSMUSG00000041797 Abca9 1277 ENSMUSG00000041831.16 ENSMUSG00000041831 Sytl3 1278 ENSMUSG00000041840.7 ENSMUSG00000041840 Haus1 1279 ENSMUSG00000041849.7 ENSMUSG00000041849 Card6 1280 ENSMUSG00000041857.10 ENSMUSG00000041857 Oosp1 1281 ENSMUSG00000041872.9 ENSMUSG00000041872 Il17f 1282 ENSMUSG00000041889.7 ENSMUSG00000041889 Shisa4 1283 ENSMUSG00000041891.15 ENSMUSG00000041891 Lman1 1284 ENSMUSG00000041895.15 ENSMUSG00000041895 Wipi1 1285 ENSMUSG00000041907.9 ENSMUSG00000041907 Gpr45 1286 ENSMUSG00000041921.16 ENSMUSG00000041921 Metap1d 1287 ENSMUSG00000041926.15 ENSMUSG00000041926 Rnpep 1288 ENSMUSG00000041961.14 ENSMUSG00000041961 Znrf3 1289 ENSMUSG00000042079.13 ENSMUSG00000042079 Hnrnpf 1290 ENSMUSG00000042082.7 ENSMUSG00000042082 Arsb 1291 ENSMUSG00000042121.16 ENSMUSG00000042121 Ssh1 1292 ENSMUSG00000042129.8 ENSMUSG00000042129 Rassf4 1293 ENSMUSG00000042182.16 ENSMUSG00000042182 Bend6 1294 ENSMUSG00000042190.12 ENSMUSG00000042190 Cmklr1 1295 ENSMUSG00000042210.17 ENSMUSG00000042210 Abhd14a 1296 ENSMUSG00000042246.5 ENSMUSG00000042246 Tmc7 1297 ENSMUSG00000042251.12 ENSMUSG00000042251 Pm20d1 1298 ENSMUSG00000042306.11 ENSMUSG00000042306 S100a14 1299 ENSMUSG00000042350.13 ENSMUSG00000042350 Arel1 1300 ENSMUSG00000042351.9 ENSMUSG00000042351 Grap2 1301 ENSMUSG00000042357.2 ENSMUSG00000042357 Gjb5 1302 ENSMUSG00000042377.8 ENSMUSG00000042377 Fam83g 1303 ENSMUSG00000042451.12 ENSMUSG00000042451 Mybph 1304 ENSMUSG00000042453.14 ENSMUSG00000042453 Reln 1305 ENSMUSG00000042462.4 ENSMUSG00000042462 Dctpp1 1306 ENSMUSG00000042515.13 ENSMUSG00000042515 Mum1l1 1307 ENSMUSG00000042599.8 ENSMUSG00000042599 Kdm7a 1308 ENSMUSG00000042650.3 ENSMUSG00000042650 Alkbh5 1309 ENSMUSG00000042724.8 ENSMUSG00000042724 Map3k9 1310 ENSMUSG00000042750.7 ENSMUSG00000042750 Bex2 1311 ENSMUSG00000042757.16 ENSMUSG00000042757 Tmem108 1312 ENSMUSG00000042784.9 ENSMUSG00000042784 Muc1 1313 ENSMUSG00000042808.8 ENSMUSG00000042808 Gpx2 1314 ENSMUSG00000042834.14 ENSMUSG00000042834 Nrep 1315 ENSMUSG00000042918.17 ENSMUSG00000042918 Mamstr 1316 ENSMUSG00000042988.10 ENSMUSG00000042988 Notum 1317 ENSMUSG00000043019.12 ENSMUSG00000043019 Edem3 1318 ENSMUSG00000043165.7 ENSMUSG00000043165 Lor 1319 ENSMUSG00000043192.4 ENSMUSG00000043192 Gm1840 1320 ENSMUSG00000043207.10 ENSMUSG00000043207 Zmpste24 1321 ENSMUSG00000043243.15 ENSMUSG00000043243 Fam129c 1322 ENSMUSG00000043263.13 ENSMUSG00000043263 Ifi209 1323 ENSMUSG00000043300.2 ENSMUSG00000043300 B3galnt1 1324 ENSMUSG00000043336.14 ENSMUSG00000043336 Filip1l

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1325 ENSMUSG00000043383.5 ENSMUSG00000043383 Olfr1342 1326 ENSMUSG00000043424.10 ENSMUSG00000043424 Eif3j2 1327 ENSMUSG00000043456.16 ENSMUSG00000043456 Zfp536 1328 ENSMUSG00000043468.4 ENSMUSG00000043468 Adam30 1329 ENSMUSG00000043557.15 ENSMUSG00000043557 Mdga1 1330 ENSMUSG00000043621.13 ENSMUSG00000043621 Ubxn10 1331 ENSMUSG00000043644.4 ENSMUSG00000043644 0610009L18Rik 1332 ENSMUSG00000043648.7 ENSMUSG00000043648 Pld6 1333 ENSMUSG00000043664.7 ENSMUSG00000043664 Tmem221 1334 ENSMUSG00000043705.7 ENSMUSG00000043705 Capn13 1335 ENSMUSG00000043822.18 ENSMUSG00000043822 Adamtsl5 1336 ENSMUSG00000043832.13 ENSMUSG00000043832 Clec4a3 1337 ENSMUSG00000043925.7 ENSMUSG00000043925 Olfr544 1338 ENSMUSG00000043932.5 ENSMUSG00000043932 Klri2 1339 ENSMUSG00000043953.12 ENSMUSG00000043953 Ccrl2 1340 ENSMUSG00000044033.16 ENSMUSG00000044033 Ccdc141 1341 ENSMUSG00000044052.3 ENSMUSG00000044052 Ccr10 1342 ENSMUSG00000044055.5 ENSMUSG00000044055 Otos 1343 ENSMUSG00000044081.7 ENSMUSG00000044081 Zfp85os 1344 ENSMUSG00000044156.14 ENSMUSG00000044156 Hepacam2 1345 ENSMUSG00000044167.6 ENSMUSG00000044167 Foxo1 1346 ENSMUSG00000044206.3 ENSMUSG00000044206 Vsig4 1347 ENSMUSG00000044211.9 ENSMUSG00000044211 Gm7887 1348 ENSMUSG00000044252.17 ENSMUSG00000044252 Osbpl1a 1349 ENSMUSG00000044258.10 ENSMUSG00000044258 Ctla2a 1350 ENSMUSG00000044265.16 ENSMUSG00000044265 Olfm5 1351 ENSMUSG00000044279.15 ENSMUSG00000044279 Crb3 1352 ENSMUSG00000044320.14 ENSMUSG00000044320 1700001O22Rik 1353 ENSMUSG00000044424.3 ENSMUSG00000044424 Gm9493 1354 ENSMUSG00000044468.14 ENSMUSG00000044468 Tent5c 1355 ENSMUSG00000044533.15 ENSMUSG00000044533 Rps2 1356 ENSMUSG00000044562.12 ENSMUSG00000044562 Rasip1 1357 ENSMUSG00000044573.16 ENSMUSG00000044573 Acp1 1358 ENSMUSG00000044600.14 ENSMUSG00000044600 Smim7 1359 ENSMUSG00000044676.10 ENSMUSG00000044676 Zfp612 1360 ENSMUSG00000044678.11 ENSMUSG00000044678 Ly6k 1361 ENSMUSG00000044694.2 ENSMUSG00000044694 2010007H06Rik 1362 ENSMUSG00000044734.16 ENSMUSG00000044734 Serpinb1a 1363 ENSMUSG00000044751.5 ENSMUSG00000044751 Gm12231 1364 ENSMUSG00000044814.6 ENSMUSG00000044814 Olfr543 1365 ENSMUSG00000044921.5 ENSMUSG00000044921 Rassf9 1366 ENSMUSG00000044934.13 ENSMUSG00000044934 Zfp367 1367 ENSMUSG00000045007.9 ENSMUSG00000045007 Tubg2 1368 ENSMUSG00000045087.8 ENSMUSG00000045087 S1pr5 1369 ENSMUSG00000045094.7 ENSMUSG00000045094 Arhgef37 1370 ENSMUSG00000045095.16 ENSMUSG00000045095 Magi1 1371 ENSMUSG00000045104.8 ENSMUSG00000045104 Gm5514 1372 ENSMUSG00000045257.10 ENSMUSG00000045257 Morn2 1373 ENSMUSG00000045268.13 ENSMUSG00000045268 Zfp691 1374 ENSMUSG00000045273.8 ENSMUSG00000045273 Cenph 1375 ENSMUSG00000045287.6 ENSMUSG00000045287 Rtn4rl1

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1376 ENSMUSG00000045294.11 ENSMUSG00000045294 Insig1 1377 ENSMUSG00000045327.7 ENSMUSG00000045327 6330549D23Rik 1378 ENSMUSG00000045377.5 ENSMUSG00000045377 Tmem88 1379 ENSMUSG00000045381.6 ENSMUSG00000045381 Olfr433 1380 ENSMUSG00000045382.6 ENSMUSG00000045382 Cxcr4 1381 ENSMUSG00000045392.8 ENSMUSG00000045392 Olfr1033 1382 ENSMUSG00000045394.8 ENSMUSG00000045394 Epcam 1383 ENSMUSG00000045410.18 ENSMUSG00000045410 Akr1e1 1384 ENSMUSG00000045441.5 ENSMUSG00000045441 Gprin3 1385 ENSMUSG00000045509.7 ENSMUSG00000045509 Gpr150 1386 ENSMUSG00000045594.10 ENSMUSG00000045594 Glb1 1387 ENSMUSG00000045636.16 ENSMUSG00000045636 Mtus1 1388 ENSMUSG00000045658.16 ENSMUSG00000045658 Pid1 1389 ENSMUSG00000045679.14 ENSMUSG00000045679 Pqlc3 1390 ENSMUSG00000045699.3 ENSMUSG00000045699 Gm21411 1391 ENSMUSG00000045775.15 ENSMUSG00000045775 Slc16a5 1392 ENSMUSG00000045777.14 ENSMUSG00000045777 Ifitm10 1393 ENSMUSG00000045842.9 ENSMUSG00000045842 Tgif2-ps2 1394 ENSMUSG00000045868.12 ENSMUSG00000045868 Gvin1 1395 ENSMUSG00000045928.2 ENSMUSG00000045928 4933440M02Rik 1396 ENSMUSG00000045930.3 ENSMUSG00000045930 Clec14a 1397 ENSMUSG00000046027.17 ENSMUSG00000046027 Stard5 1398 ENSMUSG00000046056.15 ENSMUSG00000046056 Sbsn 1399 ENSMUSG00000046152.16 ENSMUSG00000046152 Fut10 1400 ENSMUSG00000046191.7 ENSMUSG00000046191 Pcdhb20 1401 ENSMUSG00000046213.9 ENSMUSG00000046213 Cym 1402 ENSMUSG00000046295.13 ENSMUSG00000046295 Ankle1 1403 ENSMUSG00000046387.5 ENSMUSG00000046387 Pcdhb17 1404 ENSMUSG00000046402.10 ENSMUSG00000046402 Rbp1 1405 ENSMUSG00000046410.10 ENSMUSG00000046410 Kcnk6 1406 ENSMUSG00000046432.12 ENSMUSG00000046432 Bex3 1407 ENSMUSG00000046447.3 ENSMUSG00000046447 Camk2n1 1408 ENSMUSG00000046562.5 ENSMUSG00000046562 Unc119b 1409 ENSMUSG00000046589.7 ENSMUSG00000046589 Lrrc8e 1410 ENSMUSG00000046593.3 ENSMUSG00000046593 Tmem215 1411 ENSMUSG00000046623.8 ENSMUSG00000046623 Gjb4 1412 ENSMUSG00000046634.12 ENSMUSG00000046634 Pkd1l1 1413 ENSMUSG00000046636.5 ENSMUSG00000046636 Gm7729 1414 ENSMUSG00000046785.8 ENSMUSG00000046785 Epm2aip1 1415 ENSMUSG00000046807.10 ENSMUSG00000046807 Lrrc75b 1416 ENSMUSG00000046841.5 ENSMUSG00000046841 Ckap4 1417 ENSMUSG00000046916.9 ENSMUSG00000046916 Myct1 1418 ENSMUSG00000046959.16 ENSMUSG00000046959 Slc26a1 1419 ENSMUSG00000047048.4 ENSMUSG00000047048 Olfr432 1420 ENSMUSG00000047150.8 ENSMUSG00000047150 1700001C19Rik 1421 ENSMUSG00000047197.1 ENSMUSG00000047197 Gjd3 1422 ENSMUSG00000047222.7 ENSMUSG00000047222 Rnase2a 1423 ENSMUSG00000047415.12 ENSMUSG00000047415 Gpr68 1424 ENSMUSG00000047428.14 ENSMUSG00000047428 Dlk2 1425 ENSMUSG00000047462.9 ENSMUSG00000047462 Gpr141b 1426 ENSMUSG00000047511.6 ENSMUSG00000047511 Olfr1396

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1427 ENSMUSG00000047517.11 ENSMUSG00000047517 Dmbt1 1428 ENSMUSG00000047586.3 ENSMUSG00000047586 Nccrp1 1429 ENSMUSG00000047632.10 ENSMUSG00000047632 Fgfbp3 1430 ENSMUSG00000047642.15 ENSMUSG00000047642 D930020B18Rik 1431 ENSMUSG00000047657.6 ENSMUSG00000047657 Crry-ps 1432 ENSMUSG00000047719.2 ENSMUSG00000047719 Ubiad1 1433 ENSMUSG00000047766.15 ENSMUSG00000047766 Lrrc49 1434 ENSMUSG00000047793.13 ENSMUSG00000047793 Sned1 1435 ENSMUSG00000047878.13 ENSMUSG00000047878 A4galt 1436 ENSMUSG00000047904.6 ENSMUSG00000047904 Sstr2 1437 ENSMUSG00000048087.6 ENSMUSG00000048087 Gm4737 1438 ENSMUSG00000048120.16 ENSMUSG00000048120 Entpd1 1439 ENSMUSG00000048153.6 ENSMUSG00000048153 Olfr49 1440 ENSMUSG00000048218.6 ENSMUSG00000048218 Amigo2 1441 ENSMUSG00000048376.6 ENSMUSG00000048376 F2r 1442 ENSMUSG00000048402.14 ENSMUSG00000048402 Gli2 1443 ENSMUSG00000048442.15 ENSMUSG00000048442 Smim5 1444 ENSMUSG00000048480.5 ENSMUSG00000048480 Cxcr1 1445 ENSMUSG00000048498.7 ENSMUSG00000048498 Cd300e 1446 ENSMUSG00000048534.7 ENSMUSG00000048534 Jaml 1447 ENSMUSG00000048612.16 ENSMUSG00000048612 Myof 1448 ENSMUSG00000048621.3 ENSMUSG00000048621 Gm6377 1449 ENSMUSG00000048644.8 ENSMUSG00000048644 Ctxn1 1450 ENSMUSG00000048758.14 ENSMUSG00000048758 Rpl29 1451 ENSMUSG00000048852.13 ENSMUSG00000048852 Gm12185 1452 ENSMUSG00000049001.5 ENSMUSG00000049001 Ndnf 1453 ENSMUSG00000049037.8 ENSMUSG00000049037 Clec4a1 1454 ENSMUSG00000049103.14 ENSMUSG00000049103 Ccr2 1455 ENSMUSG00000049122.17 ENSMUSG00000049122 Frmd3 1456 ENSMUSG00000049123.10 ENSMUSG00000049123 Catsperg2 1457 ENSMUSG00000049307.6 ENSMUSG00000049307 Fut4 1458 ENSMUSG00000049313.8 ENSMUSG00000049313 Sorl1 1459 ENSMUSG00000049350.6 ENSMUSG00000049350 Zg16 1460 ENSMUSG00000049493.13 ENSMUSG00000049493 Pls1 1461 ENSMUSG00000049588.13 ENSMUSG00000049588 Ccdc69 1462 ENSMUSG00000049608.8 ENSMUSG00000049608 Gpr55 1463 ENSMUSG00000049620.9 ENSMUSG00000049620 Prss33 1464 ENSMUSG00000049625.6 ENSMUSG00000049625 Tifab 1465 ENSMUSG00000049744.15 ENSMUSG00000049744 Arhgap15 1466 ENSMUSG00000049985.15 ENSMUSG00000049985 Ankrd55 1467 ENSMUSG00000050052.12 ENSMUSG00000050052 Tdrp 1468 ENSMUSG00000050074.12 ENSMUSG00000050074 Spink8 1469 ENSMUSG00000050075.8 ENSMUSG00000050075 Gpr171 1470 ENSMUSG00000050108.12 ENSMUSG00000050108 Bpifc 1471 ENSMUSG00000050121.8 ENSMUSG00000050121 Opalin 1472 ENSMUSG00000050195.8 ENSMUSG00000050195 Scd4 1473 ENSMUSG00000050211.14 ENSMUSG00000050211 Pla2g4e 1474 ENSMUSG00000050232.6 ENSMUSG00000050232 Cxcr3 1475 ENSMUSG00000050241.8 ENSMUSG00000050241 Klre1 1476 ENSMUSG00000050272.10 ENSMUSG00000050272 Dscam 1477 ENSMUSG00000050315.13 ENSMUSG00000050315 Synpo2

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1478 ENSMUSG00000050350.8 ENSMUSG00000050350 Gpr18 1479 ENSMUSG00000050390.12 ENSMUSG00000050390 C77080 1480 ENSMUSG00000050473.5 ENSMUSG00000050473 Slc35d3 1481 ENSMUSG00000050490.7 ENSMUSG00000050490 Gm8394 1482 ENSMUSG00000050503.8 ENSMUSG00000050503 Fbxl22 1483 ENSMUSG00000050538.8 ENSMUSG00000050538 B230217C12Rik 1484 ENSMUSG00000050550.7 ENSMUSG00000050550 Gm11868 1485 ENSMUSG00000050666.14 ENSMUSG00000050666 Vstm4 1486 ENSMUSG00000050737.13 ENSMUSG00000050737 Ptges 1487 ENSMUSG00000050751.14 ENSMUSG00000050751 Pgbd5 1488 ENSMUSG00000050919.9 ENSMUSG00000050919 Zfp366 1489 ENSMUSG00000050921.12 ENSMUSG00000050921 P2ry10 1490 ENSMUSG00000050936.5 ENSMUSG00000050936 Gm42743 1491 ENSMUSG00000050989.9 ENSMUSG00000050989 Selenon 1492 ENSMUSG00000050994.20 ENSMUSG00000050994 Adgb 1493 ENSMUSG00000051041.7 ENSMUSG00000051041 Olfml1 1494 ENSMUSG00000051051.7 ENSMUSG00000051051 Olfr523 1495 ENSMUSG00000051111.16 ENSMUSG00000051111 Sv2c 1496 ENSMUSG00000051177.16 ENSMUSG00000051177 Plcb1 1497 ENSMUSG00000051234.6 ENSMUSG00000051234 Rnf7 1498 ENSMUSG00000051314.11 ENSMUSG00000051314 Ffar2 1499 ENSMUSG00000051344.13 ENSMUSG00000051344 Plekhm3 1500 ENSMUSG00000051354.14 ENSMUSG00000051354 Samd3 1501 ENSMUSG00000051359.15 ENSMUSG00000051359 Ncald 1502 ENSMUSG00000051437.4 ENSMUSG00000051437 Ubqlnl 1503 ENSMUSG00000051439.6 ENSMUSG00000051439 Cd14 1504 ENSMUSG00000051483.9 ENSMUSG00000051483 Cbr1 1505 ENSMUSG00000051498.6 ENSMUSG00000051498 Tlr6 1506 ENSMUSG00000051517.14 ENSMUSG00000051517 Arhgef39 1507 ENSMUSG00000051682.15 ENSMUSG00000051682 Treml4 1508 ENSMUSG00000051703.14 ENSMUSG00000051703 Tmem198 1509 ENSMUSG00000051969.7 ENSMUSG00000051969 Tlr11 1510 ENSMUSG00000051985.12 ENSMUSG00000051985 Igfn1 1511 ENSMUSG00000051998.14 ENSMUSG00000051998 Lax1 1512 ENSMUSG00000052160.7 ENSMUSG00000052160 Pld4 1513 ENSMUSG00000052271.7 ENSMUSG00000052271 Bhlha15 1514 ENSMUSG00000052303.6 ENSMUSG00000052303 Mrgpra6 1515 ENSMUSG00000052331.14 ENSMUSG00000052331 Ankrd44 1516 ENSMUSG00000052353.13 ENSMUSG00000052353 Cemip 1517 ENSMUSG00000052368.2 ENSMUSG00000052368 Gm9873 1518 ENSMUSG00000052374.16 ENSMUSG00000052374 Actn2 1519 ENSMUSG00000052631.14 ENSMUSG00000052631 Sh2d6 1520 ENSMUSG00000052730.6 ENSMUSG00000052730 Gm5111 1521 ENSMUSG00000052736.15 ENSMUSG00000052736 Klrc2 1522 ENSMUSG00000052760.16 ENSMUSG00000052760 A630001G21Rik 1523 ENSMUSG00000052783.16 ENSMUSG00000052783 Grk4 1524 ENSMUSG00000052889.11 ENSMUSG00000052889 Prkcb 1525 ENSMUSG00000052911.9 ENSMUSG00000052911 Lamb2 1526 ENSMUSG00000052914.4 ENSMUSG00000052914 Cyp2j6 1527 ENSMUSG00000052926.16 ENSMUSG00000052926 Rnaseh2a 1528 ENSMUSG00000052981.6 ENSMUSG00000052981 Ube2ql1

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1529 ENSMUSG00000053094.15 ENSMUSG00000053094 Tmem248 1530 ENSMUSG00000053101.3 ENSMUSG00000053101 Gpr141 1531 ENSMUSG00000053166.14 ENSMUSG00000053166 Cdh22 1532 ENSMUSG00000053168.6 ENSMUSG00000053168 9030619P08Rik 1533 ENSMUSG00000053198.13 ENSMUSG00000053198 Prx 1534 ENSMUSG00000053334.6 ENSMUSG00000053334 Ficd 1535 ENSMUSG00000053395.15 ENSMUSG00000053395 Cacng8 1536 ENSMUSG00000053411.16 ENSMUSG00000053411 Cbx7 1537 ENSMUSG00000053414.8 ENSMUSG00000053414 Hunk 1538 ENSMUSG00000053469.14 ENSMUSG00000053469 Tg 1539 ENSMUSG00000053475.5 ENSMUSG00000053475 Tnfaip6 1540 ENSMUSG00000053644.13 ENSMUSG00000053644 Aldh7a1 1541 ENSMUSG00000053646.13 ENSMUSG00000053646 Plxnb1 1542 ENSMUSG00000053675.8 ENSMUSG00000053675 Tgm5 1543 ENSMUSG00000053835.17 ENSMUSG00000053835 H2-T24 1544 ENSMUSG00000053957.5 ENSMUSG00000053957 Gm12474 1545 ENSMUSG00000053964.17 ENSMUSG00000053964 Lgals4 1546 ENSMUSG00000053985.10 ENSMUSG00000053985 Zfp14 1547 ENSMUSG00000054006.14 ENSMUSG00000054006 D630008O14Rik 1548 ENSMUSG00000054074.9 ENSMUSG00000054074 Skida1 1549 ENSMUSG00000054128.16 ENSMUSG00000054128 H2-T3 1550 ENSMUSG00000054136.6 ENSMUSG00000054136 Adm2 1551 ENSMUSG00000054256.11 ENSMUSG00000054256 Msi1 1552 ENSMUSG00000054263.12 ENSMUSG00000054263 Lifr 1553 ENSMUSG00000054277.8 ENSMUSG00000054277 Arfgap3 1554 ENSMUSG00000054364.5 ENSMUSG00000054364 Rhob 1555 ENSMUSG00000054408.9 ENSMUSG00000054408 Spcs3 1556 ENSMUSG00000054409.5 ENSMUSG00000054409 Tmem74 1557 ENSMUSG00000054435.16 ENSMUSG00000054435 Gimap4 1558 ENSMUSG00000054619.7 ENSMUSG00000054619 Mettl7a1 1559 ENSMUSG00000054672.13 ENSMUSG00000054672 5830411N06Rik 1560 ENSMUSG00000054679.8 ENSMUSG00000054679 Srsf12 1561 ENSMUSG00000054892.14 ENSMUSG00000054892 Txk 1562 ENSMUSG00000054934.10 ENSMUSG00000054934 Kcnmb4 1563 ENSMUSG00000055022.14 ENSMUSG00000055022 Cntn1 1564 ENSMUSG00000055069.3 ENSMUSG00000055069 Rab39 1565 ENSMUSG00000055148.7 ENSMUSG00000055148 Klf2 1566 ENSMUSG00000055214.15 ENSMUSG00000055214 Pld5 1567 ENSMUSG00000055216.3 ENSMUSG00000055216 9430025C20Rik 1568 ENSMUSG00000055312.2 ENSMUSG00000055312 Them7 1569 ENSMUSG00000055323.5 ENSMUSG00000055323 Gm9967 1570 ENSMUSG00000055452.6 ENSMUSG00000055452 Gm7353 1571 ENSMUSG00000055546.6 ENSMUSG00000055546 Timd4 1572 ENSMUSG00000055723.6 ENSMUSG00000055723 Rras2 1573 ENSMUSG00000055763.9 ENSMUSG00000055763 Rybp-ps 1574 ENSMUSG00000055826.5 ENSMUSG00000055826 Tescl 1575 ENSMUSG00000055833.14 ENSMUSG00000055833 1700034H15Rik 1576 ENSMUSG00000055895.6 ENSMUSG00000055895 Oosp2 1577 ENSMUSG00000055912.8 ENSMUSG00000055912 Tmem150a 1578 ENSMUSG00000055994.15 ENSMUSG00000055994 Nod2 1579 ENSMUSG00000056032.12 ENSMUSG00000056032 BC018473

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1580 ENSMUSG00000056043.5 ENSMUSG00000056043 Rgs9bp 1581 ENSMUSG00000056050.12 ENSMUSG00000056050 Mia3 1582 ENSMUSG00000056073.16 ENSMUSG00000056073 Grik2 1583 ENSMUSG00000056144.14 ENSMUSG00000056144 Trim34a 1584 ENSMUSG00000056155.6 ENSMUSG00000056155 Nanos3 1585 ENSMUSG00000056158.14 ENSMUSG00000056158 Car10 1586 ENSMUSG00000056174.8 ENSMUSG00000056174 Col8a2 1587 ENSMUSG00000056214.8 ENSMUSG00000056214 Pard6g 1588 ENSMUSG00000056215.13 ENSMUSG00000056215 Lrguk 1589 ENSMUSG00000056234.15 ENSMUSG00000056234 Ncoa4 1590 ENSMUSG00000056260.15 ENSMUSG00000056260 Lrif1 1591 ENSMUSG00000056267.14 ENSMUSG00000056267 Cep70 1592 ENSMUSG00000056290.15 ENSMUSG00000056290 Ms4a4b 1593 ENSMUSG00000056300.14 ENSMUSG00000056300 Zfp981 1594 ENSMUSG00000056367.14 ENSMUSG00000056367 Actr3b 1595 ENSMUSG00000056394.17 ENSMUSG00000056394 Lig1 1596 ENSMUSG00000056429.4 ENSMUSG00000056429 Tgoln1 1597 ENSMUSG00000056498.13 ENSMUSG00000056498 Tmem154 1598 ENSMUSG00000056592.14 ENSMUSG00000056592 Zfp658 1599 ENSMUSG00000056600.4 ENSMUSG00000056600 Olfr90 1600 ENSMUSG00000056888.11 ENSMUSG00000056888 Glipr1 1601 ENSMUSG00000056895.4 ENSMUSG00000056895 Hist3h2ba 1602 ENSMUSG00000057060.7 ENSMUSG00000057060 Slc35f3 1603 ENSMUSG00000057069.7 ENSMUSG00000057069 Ero1lb 1604 ENSMUSG00000057103.10 ENSMUSG00000057103 Nat8f1 1605 ENSMUSG00000057132.16 ENSMUSG00000057132 Rpgrip1 1606 ENSMUSG00000057135.12 ENSMUSG00000057135 Scimp 1607 ENSMUSG00000057163.3 ENSMUSG00000057163 Prss2 1608 ENSMUSG00000057286.6 ENSMUSG00000057286 St6galnac2 1609 ENSMUSG00000057337.13 ENSMUSG00000057337 Chst3 1610 ENSMUSG00000057378.15 ENSMUSG00000057378 Ryr3 1611 ENSMUSG00000057596.13 ENSMUSG00000057596 Trim30d 1612 ENSMUSG00000057751.14 ENSMUSG00000057751 Megf6 1613 ENSMUSG00000057895.11 ENSMUSG00000057895 Zfp105 1614 ENSMUSG00000057897.14 ENSMUSG00000057897 Camk2b 1615 ENSMUSG00000058046.1 ENSMUSG00000058046 4933430I17Rik 1616 ENSMUSG00000058064.5 ENSMUSG00000058064 Gm10036 1617 ENSMUSG00000058126.7 ENSMUSG00000058126 Tpm3-rs7 1618 ENSMUSG00000058135.12 ENSMUSG00000058135 Gstm1 1619 ENSMUSG00000058163.14 ENSMUSG00000058163 Gm5431 1620 ENSMUSG00000058174.7 ENSMUSG00000058174 Gm5148 1621 ENSMUSG00000058183.14 ENSMUSG00000058183 Mmel1 1622 ENSMUSG00000058246.8 ENSMUSG00000058246 Gm10037 1623 ENSMUSG00000058287.5 ENSMUSG00000058287 Gm12253 1624 ENSMUSG00000058567.6 ENSMUSG00000058567 Gm2531 1625 ENSMUSG00000058626.16 ENSMUSG00000058626 Capn11 1626 ENSMUSG00000058690.14 ENSMUSG00000058690 Ccser2 1627 ENSMUSG00000058740.14 ENSMUSG00000058740 Kcnt1 1628 ENSMUSG00000058743.6 ENSMUSG00000058743 Kcnj14 1629 ENSMUSG00000058966.13 ENSMUSG00000058966 Fam57b 1630 ENSMUSG00000059027.14 ENSMUSG00000059027 9630013D21Rik

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1631 ENSMUSG00000059040.4 ENSMUSG00000059040 Eno1b 1632 ENSMUSG00000059325.14 ENSMUSG00000059325 Hopx 1633 ENSMUSG00000059422.5 ENSMUSG00000059422 Gm8116 1634 ENSMUSG00000059495.14 ENSMUSG00000059495 Arhgef12 1635 ENSMUSG00000059503.2 ENSMUSG00000059503 Olfr248 1636 ENSMUSG00000059565.4 ENSMUSG00000059565 Gm5292 1637 ENSMUSG00000059639.2 ENSMUSG00000059639 Clec4a4 1638 ENSMUSG00000059714.13 ENSMUSG00000059714 Flot1 1639 ENSMUSG00000059751.7 ENSMUSG00000059751 Rps3a3 1640 ENSMUSG00000059791.14 ENSMUSG00000059791 Nrm 1641 ENSMUSG00000059810.18 ENSMUSG00000059810 Rgs3 1642 ENSMUSG00000059834.12 ENSMUSG00000059834 Sclt1 1643 ENSMUSG00000059895.13 ENSMUSG00000059895 Ptp4a3 1644 ENSMUSG00000059901.12 ENSMUSG00000059901 Adamts14 1645 ENSMUSG00000059991.7 ENSMUSG00000059991 Nptx2 1646 ENSMUSG00000060019.5 ENSMUSG00000060019 Gm10073 1647 ENSMUSG00000060044.8 ENSMUSG00000060044 Tmem26 1648 ENSMUSG00000060068.7 ENSMUSG00000060068 Gm12222 1649 ENSMUSG00000060112.4 ENSMUSG00000060112 Olfr60 1650 ENSMUSG00000060206.11 ENSMUSG00000060206 Zfp462 1651 ENSMUSG00000060275.12 ENSMUSG00000060275 Nrg2 1652 ENSMUSG00000060402.7 ENSMUSG00000060402 Chst8 1653 ENSMUSG00000060441.15 ENSMUSG00000060441 Trim5 1654 ENSMUSG00000060470.7 ENSMUSG00000060470 Adgrg3 1655 ENSMUSG00000060487.7 ENSMUSG00000060487 Samd5 1656 ENSMUSG00000060509.4 ENSMUSG00000060509 Xcr1 1657 ENSMUSG00000060550.15 ENSMUSG00000060550 H2-Q7 1658 ENSMUSG00000060591.9 ENSMUSG00000060591 Ifitm2 1659 ENSMUSG00000060636.14 ENSMUSG00000060636 Rpl35a 1660 ENSMUSG00000060639.5 ENSMUSG00000060639 Hist1h4i 1661 ENSMUSG00000060671.12 ENSMUSG00000060671 Atp8b2 1662 ENSMUSG00000060726.10 ENSMUSG00000060726 Tmsb15a 1663 ENSMUSG00000060798.7 ENSMUSG00000060798 Intu 1664 ENSMUSG00000060938.14 ENSMUSG00000060938 Rpl26 1665 ENSMUSG00000061039.5 ENSMUSG00000061039 Olfr920 1666 ENSMUSG00000061068.7 ENSMUSG00000061068 Mcpt4 1667 ENSMUSG00000061080.11 ENSMUSG00000061080 Lsamp 1668 ENSMUSG00000061132.13 ENSMUSG00000061132 Blnk 1669 ENSMUSG00000061540.3 ENSMUSG00000061540 Orm2 1670 ENSMUSG00000061577.12 ENSMUSG00000061577 Adgrg5 1671 ENSMUSG00000061666.6 ENSMUSG00000061666 Gdpd1 1672 ENSMUSG00000061684.5 ENSMUSG00000061684 Rpl21-ps8 1673 ENSMUSG00000061769.2 ENSMUSG00000061769 Klra6 1674 ENSMUSG00000061897.5 ENSMUSG00000061897 Gm14292 1675 ENSMUSG00000061972.3 ENSMUSG00000061972 Olfr99 1676 ENSMUSG00000062006.12 ENSMUSG00000062006 Rpl34 1677 ENSMUSG00000062028.8 ENSMUSG00000062028 Irgc1 1678 ENSMUSG00000062031.13 ENSMUSG00000062031 Pgghg 1679 ENSMUSG00000062070.12 ENSMUSG00000062070 Pgk1 1680 ENSMUSG00000062082.16 ENSMUSG00000062082 Cd200r4 1681 ENSMUSG00000062093.5 ENSMUSG00000062093 Gm10110

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1682 ENSMUSG00000062148.6 ENSMUSG00000062148 Ear6 1683 ENSMUSG00000062310.7 ENSMUSG00000062310 Glrp1 1684 ENSMUSG00000062345.10 ENSMUSG00000062345 Serpinb2 1685 ENSMUSG00000062353.6 ENSMUSG00000062353 Gm15772 1686 ENSMUSG00000062515.3 ENSMUSG00000062515 Fabp4 1687 ENSMUSG00000062518.7 ENSMUSG00000062518 Zfp534 1688 ENSMUSG00000062524.4 ENSMUSG00000062524 Ncr1 1689 ENSMUSG00000062585.11 ENSMUSG00000062585 Cnr2 1690 ENSMUSG00000062611.4 ENSMUSG00000062611 Rps3a2 1691 ENSMUSG00000062778.12 ENSMUSG00000062778 Chia1 1692 ENSMUSG00000062859.15 ENSMUSG00000062859 Tcp11 1693 ENSMUSG00000062980.15 ENSMUSG00000062980 Cped1 1694 ENSMUSG00000062991.7 ENSMUSG00000062991 Nrg1 1695 ENSMUSG00000062995.12 ENSMUSG00000062995 Ica1 1696 ENSMUSG00000063077.14 ENSMUSG00000063077 Kif1b 1697 ENSMUSG00000063109.13 ENSMUSG00000063109 Dgkeos 1698 ENSMUSG00000063171.4 ENSMUSG00000063171 Rps4l 1699 ENSMUSG00000063239.17 ENSMUSG00000063239 Grm4 1700 ENSMUSG00000063296.5 ENSMUSG00000063296 Tmem117 1701 ENSMUSG00000063320.11 ENSMUSG00000063320 1190007I07Rik 1702 ENSMUSG00000063354.7 ENSMUSG00000063354 Slc39a4 1703 ENSMUSG00000063388.4 ENSMUSG00000063388 BC023105 1704 ENSMUSG00000063430.9 ENSMUSG00000063430 Wscd2 1705 ENSMUSG00000063439.7 ENSMUSG00000063439 B9d2 1706 ENSMUSG00000063447.7 ENSMUSG00000063447 Ube2d2b 1707 ENSMUSG00000063522.5 ENSMUSG00000063522 2010109I03Rik 1708 ENSMUSG00000063529.3 ENSMUSG00000063529 Stmnd1 1709 ENSMUSG00000063660.4 ENSMUSG00000063660 Olfr98 1710 ENSMUSG00000063696.7 ENSMUSG00000063696 Gm8730 1711 ENSMUSG00000063698.9 ENSMUSG00000063698 Sfxn4 1712 ENSMUSG00000063931.14 ENSMUSG00000063931 Pepd 1713 ENSMUSG00000064158.6 ENSMUSG00000064158 Izumo1 1714 ENSMUSG00000064193.8 ENSMUSG00000064193 Gm4735 1715 ENSMUSG00000064262.7 ENSMUSG00000064262 Gimap8 1716 ENSMUSG00000064293.14 ENSMUSG00000064293 Cntn4 1717 ENSMUSG00000064326.13 ENSMUSG00000064326 Siva1 1718 ENSMUSG00000064337.1 ENSMUSG00000064337 mt-Rnr1 1719 ENSMUSG00000064349.1 ENSMUSG00000064349 mt-Tc 1720 ENSMUSG00000064427.1 ENSMUSG00000064427 Gm22748 1721 ENSMUSG00000065126.1 ENSMUSG00000065126 Snord104 1722 ENSMUSG00000065444.1 ENSMUSG00000065444 Mir27a 1723 ENSMUSG00000065611.1 ENSMUSG00000065611 Mir23a 1724 ENSMUSG00000065968.8 ENSMUSG00000065968 Ifitm7 1725 ENSMUSG00000066009.8 ENSMUSG00000066009 Zfp987 1726 ENSMUSG00000066060.5 ENSMUSG00000066060 Gm12866 1727 ENSMUSG00000066107.6 ENSMUSG00000066107 Gm12666 1728 ENSMUSG00000066149.11 ENSMUSG00000066149 Cdc26 1729 ENSMUSG00000066224.13 ENSMUSG00000066224 Arid3c 1730 ENSMUSG00000066258.13 ENSMUSG00000066258 Trim12a 1731 ENSMUSG00000066363.12 ENSMUSG00000066363 Serpina3f 1732 ENSMUSG00000066537.5 ENSMUSG00000066537 Vmn2r57

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1733 ENSMUSG00000066553.5 ENSMUSG00000066553 Gm6969 1734 ENSMUSG00000066613.14 ENSMUSG00000066613 Zfp932 1735 ENSMUSG00000066621.12 ENSMUSG00000066621 Tecpr1 1736 ENSMUSG00000066672.2 ENSMUSG00000066672 Olfr417 1737 ENSMUSG00000066677.12 ENSMUSG00000066677 Ifi208 1738 ENSMUSG00000066687.5 ENSMUSG00000066687 Zbtb16 1739 ENSMUSG00000066760.12 ENSMUSG00000066760 Psg16 1740 ENSMUSG00000066952.11 ENSMUSG00000066952 Myo1h 1741 ENSMUSG00000067017.5 ENSMUSG00000067017 Gm3608 1742 ENSMUSG00000067058.7 ENSMUSG00000067058 Rps15a-ps5 1743 ENSMUSG00000067149.6 ENSMUSG00000067149 Jchain 1744 ENSMUSG00000067203.7 ENSMUSG00000067203 H2-K2 1745 ENSMUSG00000067206.3 ENSMUSG00000067206 Lrrc66 1746 ENSMUSG00000067220.12 ENSMUSG00000067220 Cnga1 1747 ENSMUSG00000067235.14 ENSMUSG00000067235 H2-Q10 1748 ENSMUSG00000067285.4 ENSMUSG00000067285 Gm16223 1749 ENSMUSG00000067338.6 ENSMUSG00000067338 Tuba3b 1750 ENSMUSG00000067599.13 ENSMUSG00000067599 Klra7 1751 ENSMUSG00000067608.4 ENSMUSG00000067608 Pcna-ps2 1752 ENSMUSG00000067610.1 ENSMUSG00000067610 Klri1 1753 ENSMUSG00000067916.9 ENSMUSG00000067916 Zfp991 1754 ENSMUSG00000068101.11 ENSMUSG00000068101 Cenpm 1755 ENSMUSG00000068105.11 ENSMUSG00000068105 Tnfrsf13c 1756 ENSMUSG00000068218.6 ENSMUSG00000068218 Ssxb9 1757 ENSMUSG00000068227.9 ENSMUSG00000068227 Il2rb 1758 ENSMUSG00000068252.6 ENSMUSG00000068252 Apol7b 1759 ENSMUSG00000068259.4 ENSMUSG00000068259 Olfr461 1760 ENSMUSG00000068263.11 ENSMUSG00000068263 Efcc1 1761 ENSMUSG00000068303.6 ENSMUSG00000068303 Spr-ps1 1762 ENSMUSG00000068323.12 ENSMUSG00000068323 Slc4a5 1763 ENSMUSG00000068407.3 ENSMUSG00000068407 Rnase12 1764 ENSMUSG00000068631.8 ENSMUSG00000068631 Gm7676 1765 ENSMUSG00000068663.14 ENSMUSG00000068663 Clec16a 1766 ENSMUSG00000068699.12 ENSMUSG00000068699 Flnc 1767 ENSMUSG00000068732.5 ENSMUSG00000068732 Tmem167b 1768 ENSMUSG00000068744.12 ENSMUSG00000068744 Psrc1 1769 ENSMUSG00000068860.5 ENSMUSG00000068860 Gm128 1770 ENSMUSG00000068874.13 ENSMUSG00000068874 Selenbp1 1771 ENSMUSG00000068877.12 ENSMUSG00000068877 Selenbp2 1772 ENSMUSG00000069041.8 ENSMUSG00000069041 Slc25a31 1773 ENSMUSG00000069206.14 ENSMUSG00000069206 Zfp874a 1774 ENSMUSG00000069255.13 ENSMUSG00000069255 Dusp22 1775 ENSMUSG00000069310.4 ENSMUSG00000069310 Hist1h3c 1776 ENSMUSG00000069540.4 ENSMUSG00000069540 Gm4925 1777 ENSMUSG00000069607.4 ENSMUSG00000069607 Cd300ld3 1778 ENSMUSG00000069743.5 ENSMUSG00000069743 Zfp820 1779 ENSMUSG00000069763.3 ENSMUSG00000069763 Tmem100 1780 ENSMUSG00000069805.10 ENSMUSG00000069805 Fbp1 1781 ENSMUSG00000069833.12 ENSMUSG00000069833 Ahnak 1782 ENSMUSG00000069867.3 ENSMUSG00000069867 Pabpn1l 1783 ENSMUSG00000069917.7 ENSMUSG00000069917 Hba-a2

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1784 ENSMUSG00000069920.10 ENSMUSG00000069920 B3gnt9 1785 ENSMUSG00000069962.3 ENSMUSG00000069962 Gm5356 1786 ENSMUSG00000069996.3 ENSMUSG00000069996 Gm7125 1787 ENSMUSG00000070056.6 ENSMUSG00000070056 Mfhas1 1788 ENSMUSG00000070284.10 ENSMUSG00000070284 Gmppb 1789 ENSMUSG00000070291.4 ENSMUSG00000070291 Ddx43 1790 ENSMUSG00000070304.12 ENSMUSG00000070304 Scn2b 1791 ENSMUSG00000070305.10 ENSMUSG00000070305 Mpzl3 1792 ENSMUSG00000070369.13 ENSMUSG00000070369 Itgad 1793 ENSMUSG00000070372.11 ENSMUSG00000070372 Capza1 1794 ENSMUSG00000070390.12 ENSMUSG00000070390 Nlrp1b 1795 ENSMUSG00000070394.10 ENSMUSG00000070394 Tmem256 1796 ENSMUSG00000070407.5 ENSMUSG00000070407 Hs3st3b1 1797 ENSMUSG00000070424.12 ENSMUSG00000070424 Art5 1798 ENSMUSG00000070501.14 ENSMUSG00000070501 Ifi214 1799 ENSMUSG00000070504.9 ENSMUSG00000070504 Fcrl6 1800 ENSMUSG00000070509.15 ENSMUSG00000070509 Rgma 1801 ENSMUSG00000070564.15 ENSMUSG00000070564 Ntn5 1802 ENSMUSG00000070605.4 ENSMUSG00000070605 Zfp992 1803 ENSMUSG00000070720.3 ENSMUSG00000070720 Tmem200b 1804 ENSMUSG00000070732.2 ENSMUSG00000070732 Rbm44 1805 ENSMUSG00000070780.11 ENSMUSG00000070780 Rbm47 1806 ENSMUSG00000070802.5 ENSMUSG00000070802 Pnmal2 1807 ENSMUSG00000070803.6 ENSMUSG00000070803 Cited4 1808 ENSMUSG00000070873.5 ENSMUSG00000070873 Lilra5 1809 ENSMUSG00000071042.11 ENSMUSG00000071042 Rasgrp3 1810 ENSMUSG00000071158.9 ENSMUSG00000071158 Gm156 1811 ENSMUSG00000071203.6 ENSMUSG00000071203 Naip5 1812 ENSMUSG00000071234.3 ENSMUSG00000071234 Syndig1l 1813 ENSMUSG00000071392.6 ENSMUSG00000071392 Ect2l 1814 ENSMUSG00000071470.4 ENSMUSG00000071470 Ccnb1ip1 1815 ENSMUSG00000071540.4 ENSMUSG00000071540 3425401B19Rik 1816 ENSMUSG00000071551.13 ENSMUSG00000071551 Akr1c19 1817 ENSMUSG00000071552.5 ENSMUSG00000071552 Tigit 1818 ENSMUSG00000071561.2 ENSMUSG00000071561 BC100530 1819 ENSMUSG00000071568.5 ENSMUSG00000071568 Gm5874 1820 ENSMUSG00000071640.3 ENSMUSG00000071640 Stxbp3-ps 1821 ENSMUSG00000071713.6 ENSMUSG00000071713 Csf2rb 1822 ENSMUSG00000071714.7 ENSMUSG00000071714 Csf2rb2 1823 ENSMUSG00000071757.10 ENSMUSG00000071757 Zhx2 1824 ENSMUSG00000071796.13 ENSMUSG00000071796 6820431F20Rik 1825 ENSMUSG00000071847.12 ENSMUSG00000071847 Apcdd1 1826 ENSMUSG00000072115.11 ENSMUSG00000072115 Ang 1827 ENSMUSG00000072244.11 ENSMUSG00000072244 Trim6 1828 ENSMUSG00000072324.4 ENSMUSG00000072324 Gm8420 1829 ENSMUSG00000072494.7 ENSMUSG00000072494 Ppp1r3e 1830 ENSMUSG00000072596.4 ENSMUSG00000072596 Ear2 1831 ENSMUSG00000072599.3 ENSMUSG00000072599 Ear-ps2 1832 ENSMUSG00000072612.2 ENSMUSG00000072612 Gm10382 1833 ENSMUSG00000072618.2 ENSMUSG00000072618 Gm10384 1834 ENSMUSG00000072623.6 ENSMUSG00000072623 Zfp9

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1835 ENSMUSG00000072679.10 ENSMUSG00000072679 D6Ertd474e 1836 ENSMUSG00000072717.8 ENSMUSG00000072717 Klra11-ps 1837 ENSMUSG00000072718.6 ENSMUSG00000072718 Klra10 1838 ENSMUSG00000072774.10 ENSMUSG00000072774 Zfp951 1839 ENSMUSG00000072889.9 ENSMUSG00000072889 Nfxl1 1840 ENSMUSG00000072893.12 ENSMUSG00000072893 4933439C10Rik 1841 ENSMUSG00000072898.3 ENSMUSG00000072898 Gm10434 1842 ENSMUSG00000073008.11 ENSMUSG00000073008 Gpr174 1843 ENSMUSG00000073028.4 ENSMUSG00000073028 Igkv4-71 1844 ENSMUSG00000073145.6 ENSMUSG00000073145 Gm12000 1845 ENSMUSG00000073371.3 ENSMUSG00000073371 Gm6594 1846 ENSMUSG00000073402.11 ENSMUSG00000073402 Gm8909 1847 ENSMUSG00000073403.11 ENSMUSG00000073403 Gm10499 1848 ENSMUSG00000073405.6 ENSMUSG00000073405 H2-T-ps 1849 ENSMUSG00000073406.10 ENSMUSG00000073406 H2-Bl 1850 ENSMUSG00000073407.1 ENSMUSG00000073407 Gm6034 1851 ENSMUSG00000073489.6 ENSMUSG00000073489 Ifi204 1852 ENSMUSG00000073490.11 ENSMUSG00000073490 Ifi207 1853 ENSMUSG00000073494.5 ENSMUSG00000073494 Sh2d1b2 1854 ENSMUSG00000073529.9 ENSMUSG00000073529 F830208F22Rik 1855 ENSMUSG00000073538.10 ENSMUSG00000073538 E330020D12Rik 1856 ENSMUSG00000073643.11 ENSMUSG00000073643 Wdfy1 1857 ENSMUSG00000073678.4 ENSMUSG00000073678 Pgap1 1858 ENSMUSG00000073716.6 ENSMUSG00000073716 Gm13241 1859 ENSMUSG00000073728.10 ENSMUSG00000073728 Tmem51os1 1860 ENSMUSG00000073862.4 ENSMUSG00000073862 Gm5600 1861 ENSMUSG00000073889.10 ENSMUSG00000073889 Il11ra1 1862 ENSMUSG00000073902.5 ENSMUSG00000073902 Gm1966 1863 ENSMUSG00000073938.3 ENSMUSG00000073938 Olfr632 1864 ENSMUSG00000074115.5 ENSMUSG00000074115 Saa1 1865 ENSMUSG00000074121.3 ENSMUSG00000074121 Ntf5 1866 ENSMUSG00000074129.14 ENSMUSG00000074129 Rpl13a 1867 ENSMUSG00000074158.9 ENSMUSG00000074158 Zfp976 1868 ENSMUSG00000074194.4 ENSMUSG00000074194 Zfp791 1869 ENSMUSG00000074195.3 ENSMUSG00000074195 Clca4b 1870 ENSMUSG00000074252.2 ENSMUSG00000074252 Gm10654 1871 ENSMUSG00000074272.10 ENSMUSG00000074272 Ceacam1 1872 ENSMUSG00000074277.4 ENSMUSG00000074277 Phldb3 1873 ENSMUSG00000074280.6 ENSMUSG00000074280 Gm6166 1874 ENSMUSG00000074340.9 ENSMUSG00000074340 Ovgp1 1875 ENSMUSG00000074358.9 ENSMUSG00000074358 Ccdc61 1876 ENSMUSG00000074417.9 ENSMUSG00000074417 Gm14548 1877 ENSMUSG00000074420.5 ENSMUSG00000074420 Gm10693 1878 ENSMUSG00000074457.10 ENSMUSG00000074457 S100a16 1879 ENSMUSG00000074476.6 ENSMUSG00000074476 Spc24 1880 ENSMUSG00000074479.3 ENSMUSG00000074479 Gm10704 1881 ENSMUSG00000074505.5 ENSMUSG00000074505 Fat3 1882 ENSMUSG00000074575.4 ENSMUSG00000074575 Kcng1 1883 ENSMUSG00000074578.13 ENSMUSG00000074578 Zfas1 1884 ENSMUSG00000074604.9 ENSMUSG00000074604 Mgst2 1885 ENSMUSG00000074673.15 ENSMUSG00000074673 Ttll9

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1886 ENSMUSG00000074680.1 ENSMUSG00000074680 Defb26 1887 ENSMUSG00000074731.3 ENSMUSG00000074731 Zfp345 1888 ENSMUSG00000074735.2 ENSMUSG00000074735 Gm21994 1889 ENSMUSG00000074743.4 ENSMUSG00000074743 Thbd 1890 ENSMUSG00000074865.11 ENSMUSG00000074865 Zfp934 1891 ENSMUSG00000074899.5 ENSMUSG00000074899 Sptbn5 1892 ENSMUSG00000075265.4 ENSMUSG00000075265 Tnk2os 1893 ENSMUSG00000075269.5 ENSMUSG00000075269 Bex6 1894 ENSMUSG00000075289.4 ENSMUSG00000075289 Carns1 1895 ENSMUSG00000075307.3 ENSMUSG00000075307 Klhl41 1896 ENSMUSG00000075334.2 ENSMUSG00000075334 Rprm 1897 ENSMUSG00000075391.6 ENSMUSG00000075391 Gm13443 1898 ENSMUSG00000075410.12 ENSMUSG00000075410 Prcd 1899 ENSMUSG00000075420.6 ENSMUSG00000075420 Smim6 1900 ENSMUSG00000075602.10 ENSMUSG00000075602 Ly6a 1901 ENSMUSG00000075701.9 ENSMUSG00000075701 Selenos 1902 ENSMUSG00000076060.1 ENSMUSG00000076060 Mir704 1903 ENSMUSG00000076437.10 ENSMUSG00000076437 Selenoh 1904 ENSMUSG00000076471.3 ENSMUSG00000076471 Trbv14 1905 ENSMUSG00000076483.1 ENSMUSG00000076483 Trbj1-1 1906 ENSMUSG00000076484.1 ENSMUSG00000076484 Trbj1-2 1907 ENSMUSG00000076485.2 ENSMUSG00000076485 Trbj1-3 1908 ENSMUSG00000076486.1 ENSMUSG00000076486 Trbj1-4 1909 ENSMUSG00000076487.1 ENSMUSG00000076487 Trbj1-5 1910 ENSMUSG00000076488.1 ENSMUSG00000076488 Trbj1-6 1911 ENSMUSG00000076489.2 ENSMUSG00000076489 Trbj1-7 1912 ENSMUSG00000076496.1 ENSMUSG00000076496 Trbj2-5 1913 ENSMUSG00000076498.2 ENSMUSG00000076498 Trbc2 1914 ENSMUSG00000076499.3 ENSMUSG00000076499 Trbv31 1915 ENSMUSG00000076500.2 ENSMUSG00000076500 Gm20730 1916 ENSMUSG00000076501.2 ENSMUSG00000076501 Igkv2-137 1917 ENSMUSG00000076505.1 ENSMUSG00000076505 Igkv1-131 1918 ENSMUSG00000076508.3 ENSMUSG00000076508 Igkv17-127 1919 ENSMUSG00000076512.2 ENSMUSG00000076512 Igkv9-123 1920 ENSMUSG00000076514.3 ENSMUSG00000076514 Igkv17-121 1921 ENSMUSG00000076518.6 ENSMUSG00000076518 Igkv2-112 1922 ENSMUSG00000076522.2 ENSMUSG00000076522 Igkv16-104 1923 ENSMUSG00000076523.2 ENSMUSG00000076523 Igkv15-103 1924 ENSMUSG00000076526.6 ENSMUSG00000076526 Igkv12-98 1925 ENSMUSG00000076532.3 ENSMUSG00000076532 Igkv4-91 1926 ENSMUSG00000076534.6 ENSMUSG00000076534 Igkv12-89 1927 ENSMUSG00000076535.1 ENSMUSG00000076535 Igkv1-88 1928 ENSMUSG00000076536.3 ENSMUSG00000076536 Igkv4-86 1929 ENSMUSG00000076538.1 ENSMUSG00000076538 Igkv13-84 1930 ENSMUSG00000076539.3 ENSMUSG00000076539 Igkv4-81 1931 ENSMUSG00000076540.3 ENSMUSG00000076540 Igkv4-80 1932 ENSMUSG00000076541.3 ENSMUSG00000076541 Igkv4-79 1933 ENSMUSG00000076543.2 ENSMUSG00000076543 Igkv4-74 1934 ENSMUSG00000076545.2 ENSMUSG00000076545 Igkv4-72 1935 ENSMUSG00000076547.2 ENSMUSG00000076547 Igkv4-70 1936 ENSMUSG00000076549.2 ENSMUSG00000076549 Igkv4-68

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1937 ENSMUSG00000076550.3 ENSMUSG00000076550 Igkv4-63 1938 ENSMUSG00000076552.3 ENSMUSG00000076552 Igkv4-61 1939 ENSMUSG00000076555.3 ENSMUSG00000076555 Igkv4-57-1 1940 ENSMUSG00000076556.3 ENSMUSG00000076556 Igkv4-57 1941 ENSMUSG00000076562.1 ENSMUSG00000076562 Igkv4-50 1942 ENSMUSG00000076563.2 ENSMUSG00000076563 Igkv5-48 1943 ENSMUSG00000076564.2 ENSMUSG00000076564 Igkv12-46 1944 ENSMUSG00000076571.2 ENSMUSG00000076571 Igkv5-37 1945 ENSMUSG00000076572.6 ENSMUSG00000076572 Igkv18-36 1946 ENSMUSG00000076573.6 ENSMUSG00000076573 Igkv1-35 1947 ENSMUSG00000076576.2 ENSMUSG00000076576 Igkv6-32 1948 ENSMUSG00000076577.2 ENSMUSG00000076577 Igkv8-30 1949 ENSMUSG00000076580.3 ENSMUSG00000076580 Igkv8-27 1950 ENSMUSG00000076581.1 ENSMUSG00000076581 Igkv8-26 1951 ENSMUSG00000076583.1 ENSMUSG00000076583 Igkv8-24 1952 ENSMUSG00000076586.2 ENSMUSG00000076586 Igkv8-21 1953 ENSMUSG00000076589.2 ENSMUSG00000076589 Igkv8-18 1954 ENSMUSG00000076594.2 ENSMUSG00000076594 Igkv6-13 1955 ENSMUSG00000076596.3 ENSMUSG00000076596 Igkv3-10 1956 ENSMUSG00000076598.3 ENSMUSG00000076598 Igkv3-7 1957 ENSMUSG00000076604.1 ENSMUSG00000076604 Igkj1 1958 ENSMUSG00000076605.2 ENSMUSG00000076605 Igkj2 1959 ENSMUSG00000076606.3 ENSMUSG00000076606 Igkj3 1960 ENSMUSG00000076607.1 ENSMUSG00000076607 Igkj4 1961 ENSMUSG00000076608.2 ENSMUSG00000076608 Igkj5 1962 ENSMUSG00000076609.2 ENSMUSG00000076609 Igkc 1963 ENSMUSG00000076615.4 ENSMUSG00000076615 Ighg3 1964 ENSMUSG00000076617.9 ENSMUSG00000076617 Ighm 1965 ENSMUSG00000076618.1 ENSMUSG00000076618 Ighj4 1966 ENSMUSG00000076619.1 ENSMUSG00000076619 Ighj3 1967 ENSMUSG00000076620.2 ENSMUSG00000076620 Ighj2 1968 ENSMUSG00000076621.1 ENSMUSG00000076621 Ighj1 1969 ENSMUSG00000076630.1 ENSMUSG00000076630 Ighd1-1 1970 ENSMUSG00000076633.7 ENSMUSG00000076633 Ighv5-2 1971 ENSMUSG00000076646.3 ENSMUSG00000076646 Ighv2-6-8 1972 ENSMUSG00000076652.4 ENSMUSG00000076652 Ighv7-3 1973 ENSMUSG00000076653.4 ENSMUSG00000076653 Ighv7-2 1974 ENSMUSG00000076655.2 ENSMUSG00000076655 Ighv4-1 1975 ENSMUSG00000076665.4 ENSMUSG00000076665 Ighv7-1 1976 ENSMUSG00000076666.2 ENSMUSG00000076666 Ighv14-4 1977 ENSMUSG00000076668.4 ENSMUSG00000076668 Ighv7-4 1978 ENSMUSG00000076671.5 ENSMUSG00000076671 Ighv13-2 1979 ENSMUSG00000076672.7 ENSMUSG00000076672 Ighv3-6 1980 ENSMUSG00000076674.2 ENSMUSG00000076674 Ighv3-8 1981 ENSMUSG00000076676.2 ENSMUSG00000076676 Ighv12-3 1982 ENSMUSG00000076680.1 ENSMUSG00000076680 Ighv6-6 1983 ENSMUSG00000076688.2 ENSMUSG00000076688 Ighv15-2 1984 ENSMUSG00000076695.7 ENSMUSG00000076695 Ighv1-18 1985 ENSMUSG00000076709.2 ENSMUSG00000076709 Ighv1-47 1986 ENSMUSG00000076731.3 ENSMUSG00000076731 Ighv8-12 1987 ENSMUSG00000076745.4 ENSMUSG00000076745 Tcrg-V4

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1988 ENSMUSG00000076752.2 ENSMUSG00000076752 Tcrg-C2 1989 ENSMUSG00000076754.2 ENSMUSG00000076754 Trgv2 1990 ENSMUSG00000076755.2 ENSMUSG00000076755 Tcrg-V1 1991 ENSMUSG00000076846.3 ENSMUSG00000076846 Trav13-2 1992 ENSMUSG00000076870.2 ENSMUSG00000076870 Trdj1 1993 ENSMUSG00000076871.1 ENSMUSG00000076871 Trdj2 1994 ENSMUSG00000076928.5 ENSMUSG00000076928 Trac 1995 ENSMUSG00000076934.2 ENSMUSG00000076934 Iglv1 1996 ENSMUSG00000076937.3 ENSMUSG00000076937 Iglc2 1997 ENSMUSG00000076939.2 ENSMUSG00000076939 Iglv3 1998 ENSMUSG00000076940.3 ENSMUSG00000076940 Iglv2 1999 ENSMUSG00000076961.1 ENSMUSG00000076961 Gm23251 2000 ENSMUSG00000077273.1 ENSMUSG00000077273 Gm22779 2001 ENSMUSG00000078122.4 ENSMUSG00000078122 F630028O10Rik 2002 ENSMUSG00000078139.3 ENSMUSG00000078139 AK157302 2003 ENSMUSG00000078160.2 ENSMUSG00000078160 Gm16503 2004 ENSMUSG00000078161.8 ENSMUSG00000078161 Erich3 2005 ENSMUSG00000078183.3 ENSMUSG00000078183 Gm15610 2006 ENSMUSG00000078184.1 ENSMUSG00000078184 Rbm8a2 2007 ENSMUSG00000078247.4 ENSMUSG00000078247 Airn 2008 ENSMUSG00000078249.5 ENSMUSG00000078249 Hmga1b 2009 ENSMUSG00000078480.3 ENSMUSG00000078480 Mrpl48-ps 2010 ENSMUSG00000078490.9 ENSMUSG00000078490 Cfap74 2011 ENSMUSG00000078495.10 ENSMUSG00000078495 Zfp984 2012 ENSMUSG00000078503.9 ENSMUSG00000078503 Zfp990 2013 ENSMUSG00000078519.3 ENSMUSG00000078519 2310026L22Rik 2014 ENSMUSG00000078521.2 ENSMUSG00000078521 Aunip 2015 ENSMUSG00000078554.2 ENSMUSG00000078554 Fam229a 2016 ENSMUSG00000078586.3 ENSMUSG00000078586 Gm11735 2017 ENSMUSG00000078606.8 ENSMUSG00000078606 Gm4070 2018 ENSMUSG00000078762.10 ENSMUSG00000078762 Haus5 2019 ENSMUSG00000078796.4 ENSMUSG00000078796 Zfp541 2020 ENSMUSG00000078815.8 ENSMUSG00000078815 Cacng6 2021 ENSMUSG00000078851.4 ENSMUSG00000078851 Hist3h2a 2022 ENSMUSG00000078902.3 ENSMUSG00000078902 Gm14443 2023 ENSMUSG00000078921.3 ENSMUSG00000078921 Tgtp2 2024 ENSMUSG00000078954.9 ENSMUSG00000078954 Arhgap8 2025 ENSMUSG00000078994.9 ENSMUSG00000078994 Zfp429 2026 ENSMUSG00000079018.10 ENSMUSG00000079018 Ly6c1 2027 ENSMUSG00000079022.10 ENSMUSG00000079022 Col22a1 2028 ENSMUSG00000079033.10 ENSMUSG00000079033 Mef2b 2029 ENSMUSG00000079037.9 ENSMUSG00000079037 Prnp 2030 ENSMUSG00000079056.12 ENSMUSG00000079056 Kcnip3 2031 ENSMUSG00000079071.2 ENSMUSG00000079071 Gm14085 2032 ENSMUSG00000079111.3 ENSMUSG00000079111 Kdelr2 2033 ENSMUSG00000079138.3 ENSMUSG00000079138 Gm8818 2034 ENSMUSG00000079164.8 ENSMUSG00000079164 Tlr5 2035 ENSMUSG00000079223.3 ENSMUSG00000079223 Gm8778 2036 ENSMUSG00000079227.10 ENSMUSG00000079227 Ccr5 2037 ENSMUSG00000079298.9 ENSMUSG00000079298 Klrb1b 2038 ENSMUSG00000079299.3 ENSMUSG00000079299 Klrb1

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

2039 ENSMUSG00000079363.7 ENSMUSG00000079363 Gbp4 2040 ENSMUSG00000079427.10 ENSMUSG00000079427 Mthfsl 2041 ENSMUSG00000079470.8 ENSMUSG00000079470 Utp14b 2042 ENSMUSG00000079481.11 ENSMUSG00000079481 Nhsl2 2043 ENSMUSG00000079492.2 ENSMUSG00000079492 Gm11127 2044 ENSMUSG00000079507.10 ENSMUSG00000079507 H2-Q1 2045 ENSMUSG00000079547.3 ENSMUSG00000079547 H2-DMb1 2046 ENSMUSG00000079550.9 ENSMUSG00000079550 Mpp4 2047 ENSMUSG00000079553.10 ENSMUSG00000079553 Kifc1 2048 ENSMUSG00000079554.2 ENSMUSG00000079554 Aox2 2049 ENSMUSG00000079559.4 ENSMUSG00000079559 Colca2 2050 ENSMUSG00000079575.3 ENSMUSG00000079575 Rbpj-ps3 2051 ENSMUSG00000079645.2 ENSMUSG00000079645 Gm17193 2052 ENSMUSG00000079671.8 ENSMUSG00000079671 2610203C22Rik 2053 ENSMUSG00000079685.10 ENSMUSG00000079685 Ulbp1 2054 ENSMUSG00000079852.4 ENSMUSG00000079852 Klra4 2055 ENSMUSG00000079853.5 ENSMUSG00000079853 Klra1 2056 ENSMUSG00000079941.1 ENSMUSG00000079941 Gm11273 2057 ENSMUSG00000080115.3 ENSMUSG00000080115 Eef1akmt3 2058 ENSMUSG00000080242.5 ENSMUSG00000080242 Atp6v0c-ps2 2059 ENSMUSG00000080775.1 ENSMUSG00000080775 Gm6368 2060 ENSMUSG00000080895.1 ENSMUSG00000080895 Gm11645 2061 ENSMUSG00000080917.2 ENSMUSG00000080917 Gm15925 2062 ENSMUSG00000080939.1 ENSMUSG00000080939 Gm9208 2063 ENSMUSG00000080977.1 ENSMUSG00000080977 Gm13772 2064 ENSMUSG00000081111.3 ENSMUSG00000081111 Gm5913 2065 ENSMUSG00000081223.1 ENSMUSG00000081223 Gm12247 2066 ENSMUSG00000081355.1 ENSMUSG00000081355 Gm15264 2067 ENSMUSG00000081400.1 ENSMUSG00000081400 Gm13680 2068 ENSMUSG00000081417.1 ENSMUSG00000081417 Gm15603 2069 ENSMUSG00000081434.3 ENSMUSG00000081434 Gm14165 2070 ENSMUSG00000081490.1 ENSMUSG00000081490 Gm11830 2071 ENSMUSG00000081512.1 ENSMUSG00000081512 Gm15821 2072 ENSMUSG00000081553.1 ENSMUSG00000081553 Ccdc50-ps 2073 ENSMUSG00000081603.1 ENSMUSG00000081603 Gm14681 2074 ENSMUSG00000081640.1 ENSMUSG00000081640 Rplp0-ps1 2075 ENSMUSG00000081665.2 ENSMUSG00000081665 Gm15922 2076 ENSMUSG00000081669.1 ENSMUSG00000081669 Npm3-ps1 2077 ENSMUSG00000081684.4 ENSMUSG00000081684 Rps2-ps13 2078 ENSMUSG00000081723.1 ENSMUSG00000081723 Gm15931 2079 ENSMUSG00000081739.3 ENSMUSG00000081739 Mdm4-ps 2080 ENSMUSG00000081788.2 ENSMUSG00000081788 Gm5898 2081 ENSMUSG00000081824.5 ENSMUSG00000081824 BC002163 2082 ENSMUSG00000081998.1 ENSMUSG00000081998 Gm13245 2083 ENSMUSG00000082062.1 ENSMUSG00000082062 Ftl2-ps 2084 ENSMUSG00000082069.2 ENSMUSG00000082069 Gm16242 2085 ENSMUSG00000082079.2 ENSMUSG00000082079 Dnmt3c 2086 ENSMUSG00000082082.1 ENSMUSG00000082082 Gm13230 2087 ENSMUSG00000082154.1 ENSMUSG00000082154 Gm16464 2088 ENSMUSG00000082192.2 ENSMUSG00000082192 Gm14719 2089 ENSMUSG00000082194.3 ENSMUSG00000082194 Gm12444

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

2090 ENSMUSG00000082286.10 ENSMUSG00000082286 Pisd-ps1 2091 ENSMUSG00000082419.3 ENSMUSG00000082419 Gm11425 2092 ENSMUSG00000082431.3 ENSMUSG00000082431 Tdpx-ps1 2093 ENSMUSG00000082536.1 ENSMUSG00000082536 Gm13456 2094 ENSMUSG00000082599.3 ENSMUSG00000082599 Gm13141 2095 ENSMUSG00000082706.1 ENSMUSG00000082706 Gm11663 2096 ENSMUSG00000082791.3 ENSMUSG00000082791 Gm4875 2097 ENSMUSG00000082815.2 ENSMUSG00000082815 Gm5678 2098 ENSMUSG00000082884.1 ENSMUSG00000082884 Gm13339 2099 ENSMUSG00000082922.3 ENSMUSG00000082922 Gm6939 2100 ENSMUSG00000082935.3 ENSMUSG00000082935 Gm7658 2101 ENSMUSG00000082956.4 ENSMUSG00000082956 Naip3 2102 ENSMUSG00000083076.1 ENSMUSG00000083076 Gm11408 2103 ENSMUSG00000083120.3 ENSMUSG00000083120 Gm15854 2104 ENSMUSG00000083165.1 ENSMUSG00000083165 Gm11344 2105 ENSMUSG00000083178.1 ENSMUSG00000083178 Gm12187 2106 ENSMUSG00000083218.2 ENSMUSG00000083218 Gm16425 2107 ENSMUSG00000083219.1 ENSMUSG00000083219 Gm11410 2108 ENSMUSG00000083240.3 ENSMUSG00000083240 Gm13453 2109 ENSMUSG00000083246.1 ENSMUSG00000083246 Gm11839 2110 ENSMUSG00000083268.1 ENSMUSG00000083268 Gm11511 2111 ENSMUSG00000083332.1 ENSMUSG00000083332 Gm7599 2112 ENSMUSG00000083364.4 ENSMUSG00000083364 Llph-ps2 2113 ENSMUSG00000083367.1 ENSMUSG00000083367 Gm8806 2114 ENSMUSG00000083563.1 ENSMUSG00000083563 Gm13340 2115 ENSMUSG00000083623.1 ENSMUSG00000083623 Gm7224 2116 ENSMUSG00000083645.1 ENSMUSG00000083645 Gm14086 2117 ENSMUSG00000083679.1 ENSMUSG00000083679 Gm12892 2118 ENSMUSG00000083693.1 ENSMUSG00000083693 Gm11971 2119 ENSMUSG00000083708.1 ENSMUSG00000083708 Gm13123 2120 ENSMUSG00000083773.4 ENSMUSG00000083773 Gm13394 2121 ENSMUSG00000083856.1 ENSMUSG00000083856 Gm13886 2122 ENSMUSG00000083902.2 ENSMUSG00000083902 Gm15975 2123 ENSMUSG00000083914.3 ENSMUSG00000083914 Rps18-ps1 2124 ENSMUSG00000084198.1 ENSMUSG00000084198 Gm13711 2125 ENSMUSG00000084224.1 ENSMUSG00000084224 Gm12337 2126 ENSMUSG00000084329.1 ENSMUSG00000084329 Gm6733 2127 ENSMUSG00000084342.1 ENSMUSG00000084342 Gm11224 2128 ENSMUSG00000084347.3 ENSMUSG00000084347 Akt2-ps 2129 ENSMUSG00000084349.3 ENSMUSG00000084349 Rpl3-ps1 2130 ENSMUSG00000084350.1 ENSMUSG00000084350 Znf41-ps 2131 ENSMUSG00000084407.1 ENSMUSG00000084407 Gm14018 2132 ENSMUSG00000084603.1 ENSMUSG00000084603 Gm22204 2133 ENSMUSG00000084803.8 ENSMUSG00000084803 5830444B04Rik 2134 ENSMUSG00000084826.7 ENSMUSG00000084826 AI847159 2135 ENSMUSG00000084899.1 ENSMUSG00000084899 Gm15344 2136 ENSMUSG00000084960.1 ENSMUSG00000084960 B430010I23Rik 2137 ENSMUSG00000084970.1 ENSMUSG00000084970 1700060J05Rik 2138 ENSMUSG00000085016.1 ENSMUSG00000085016 Gm11335 2139 ENSMUSG00000085024.1 ENSMUSG00000085024 C230035I16Rik 2140 ENSMUSG00000085037.1 ENSMUSG00000085037 4933421O10Rik

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

2141 ENSMUSG00000085084.7 ENSMUSG00000085084 4930570G19Rik 2142 ENSMUSG00000085133.2 ENSMUSG00000085133 B930095G15Rik 2143 ENSMUSG00000085184.9 ENSMUSG00000085184 4933439K11Rik 2144 ENSMUSG00000085249.1 ENSMUSG00000085249 Gm12847 2145 ENSMUSG00000085282.8 ENSMUSG00000085282 Gm15663 2146 ENSMUSG00000085359.1 ENSMUSG00000085359 Gm12336 2147 ENSMUSG00000085492.7 ENSMUSG00000085492 Trmt61b 2148 ENSMUSG00000085521.4 ENSMUSG00000085521 4930526A20Rik 2149 ENSMUSG00000085601.7 ENSMUSG00000085601 Gm4969 2150 ENSMUSG00000085627.2 ENSMUSG00000085627 Gm11222 2151 ENSMUSG00000085651.1 ENSMUSG00000085651 Gm11695 2152 ENSMUSG00000085666.3 ENSMUSG00000085666 Gm9855 2153 ENSMUSG00000085672.1 ENSMUSG00000085672 Gm16193 2154 ENSMUSG00000085743.1 ENSMUSG00000085743 8430419K02Rik 2155 ENSMUSG00000085744.1 ENSMUSG00000085744 Gm12259 2156 ENSMUSG00000085776.8 ENSMUSG00000085776 5430402O13Rik 2157 ENSMUSG00000085786.1 ENSMUSG00000085786 Gm15987 2158 ENSMUSG00000085823.7 ENSMUSG00000085823 Gm13012 2159 ENSMUSG00000085837.8 ENSMUSG00000085837 Kcnmb4os2 2160 ENSMUSG00000085872.1 ENSMUSG00000085872 Gm11505 2161 ENSMUSG00000085882.1 ENSMUSG00000085882 2610507I01Rik 2162 ENSMUSG00000085887.2 ENSMUSG00000085887 Arhgap27os3 2163 ENSMUSG00000085890.7 ENSMUSG00000085890 Tnfsf13os 2164 ENSMUSG00000085918.1 ENSMUSG00000085918 Gm13032 2165 ENSMUSG00000085936.7 ENSMUSG00000085936 2610307P16Rik 2166 ENSMUSG00000085995.2 ENSMUSG00000085995 Gm2788 2167 ENSMUSG00000086010.7 ENSMUSG00000086010 Gm15318 2168 ENSMUSG00000086013.1 ENSMUSG00000086013 Gm15706 2169 ENSMUSG00000086040.8 ENSMUSG00000086040 Wipf3 2170 ENSMUSG00000086076.1 ENSMUSG00000086076 Ncr3-ps 2171 ENSMUSG00000086111.1 ENSMUSG00000086111 Gm15326 2172 ENSMUSG00000086162.1 ENSMUSG00000086162 Gm16342 2173 ENSMUSG00000086291.1 ENSMUSG00000086291 Gm15513 2174 ENSMUSG00000086350.1 ENSMUSG00000086350 B230369F24Rik 2175 ENSMUSG00000086353.1 ENSMUSG00000086353 Gm13481 2176 ENSMUSG00000086390.7 ENSMUSG00000086390 1810019D21Rik 2177 ENSMUSG00000086395.1 ENSMUSG00000086395 A630014C17Rik 2178 ENSMUSG00000086446.1 ENSMUSG00000086446 Prkag2os1 2179 ENSMUSG00000086459.2 ENSMUSG00000086459 1700030C12Rik 2180 ENSMUSG00000086468.1 ENSMUSG00000086468 Etaa1os 2181 ENSMUSG00000086472.1 ENSMUSG00000086472 Gm16172 2182 ENSMUSG00000086495.7 ENSMUSG00000086495 Gm13778 2183 ENSMUSG00000086513.3 ENSMUSG00000086513 9130208D14Rik 2184 ENSMUSG00000086534.2 ENSMUSG00000086534 Gm16758 2185 ENSMUSG00000086600.8 ENSMUSG00000086600 C030005K06Rik 2186 ENSMUSG00000086629.8 ENSMUSG00000086629 2810403D21Rik 2187 ENSMUSG00000086652.1 ENSMUSG00000086652 Gm14029 2188 ENSMUSG00000086695.1 ENSMUSG00000086695 Gm15247 2189 ENSMUSG00000086712.2 ENSMUSG00000086712 AI427809 2190 ENSMUSG00000086750.1 ENSMUSG00000086750 Gm11770 2191 ENSMUSG00000086763.1 ENSMUSG00000086763 Plxna4os1

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

2192 ENSMUSG00000086765.7 ENSMUSG00000086765 Gm11827 2193 ENSMUSG00000086795.1 ENSMUSG00000086795 Gm11579 2194 ENSMUSG00000086884.1 ENSMUSG00000086884 Gm16225 2195 ENSMUSG00000086918.1 ENSMUSG00000086918 4930429F24Rik 2196 ENSMUSG00000086938.8 ENSMUSG00000086938 4930481A15Rik 2197 ENSMUSG00000086962.4 ENSMUSG00000086962 Gm12248 2198 ENSMUSG00000087004.1 ENSMUSG00000087004 Gm14154 2199 ENSMUSG00000087008.4 ENSMUSG00000087008 Gm5530 2200 ENSMUSG00000087054.1 ENSMUSG00000087054 Gm12405 2201 ENSMUSG00000087151.1 ENSMUSG00000087151 Gm14022 2202 ENSMUSG00000087153.8 ENSMUSG00000087153 Gm6483 2203 ENSMUSG00000087228.1 ENSMUSG00000087228 Gm12827 2204 ENSMUSG00000087246.1 ENSMUSG00000087246 Gm13346 2205 ENSMUSG00000087259.7 ENSMUSG00000087259 2610035D17Rik 2206 ENSMUSG00000087273.1 ENSMUSG00000087273 Gm13203 2207 ENSMUSG00000087277.1 ENSMUSG00000087277 2010013B24Rik 2208 ENSMUSG00000087279.10 ENSMUSG00000087279 4930544D05Rik 2209 ENSMUSG00000087292.1 ENSMUSG00000087292 Gm13832 2210 ENSMUSG00000087303.2 ENSMUSG00000087303 Lipo2 2211 ENSMUSG00000087305.8 ENSMUSG00000087305 A430035B10Rik 2212 ENSMUSG00000087347.1 ENSMUSG00000087347 1700047K16Rik 2213 ENSMUSG00000087362.7 ENSMUSG00000087362 Gm13710 2214 ENSMUSG00000087452.1 ENSMUSG00000087452 Gm11998 2215 ENSMUSG00000087502.1 ENSMUSG00000087502 Gm16091 2216 ENSMUSG00000087530.2 ENSMUSG00000087530 Gm15533 2217 ENSMUSG00000087547.1 ENSMUSG00000087547 Platr27 2218 ENSMUSG00000087574.1 ENSMUSG00000087574 C030037D09Rik 2219 ENSMUSG00000087582.6 ENSMUSG00000087582 Ighv6-7 2220 ENSMUSG00000087590.2 ENSMUSG00000087590 Epb41l4aos 2221 ENSMUSG00000087627.2 ENSMUSG00000087627 A230059L01Rik 2222 ENSMUSG00000087633.1 ENSMUSG00000087633 Gm14455 2223 ENSMUSG00000087651.3 ENSMUSG00000087651 1500009L16Rik 2224 ENSMUSG00000087691.1 ENSMUSG00000087691 Gm15674 2225 ENSMUSG00000088901.1 ENSMUSG00000088901 Mir1943 2226 ENSMUSG00000089365.1 ENSMUSG00000089365 Gm23823 2227 ENSMUSG00000089675.1 ENSMUSG00000089675 Ugt1a8 2228 ENSMUSG00000089678.8 ENSMUSG00000089678 Agxt2 2229 ENSMUSG00000089679.1 ENSMUSG00000089679 Gm16299 2230 ENSMUSG00000089700.1 ENSMUSG00000089700 Gm2343 2231 ENSMUSG00000089718.1 ENSMUSG00000089718 2310075C17Rik 2232 ENSMUSG00000089727.2 ENSMUSG00000089727 Klra8 2233 ENSMUSG00000089735.1 ENSMUSG00000089735 Gm8428 2234 ENSMUSG00000089768.2 ENSMUSG00000089768 Tmsb15b1 2235 ENSMUSG00000089901.1 ENSMUSG00000089901 Gm8113 2236 ENSMUSG00000089929.1 ENSMUSG00000089929 Bcl2a1b 2237 ENSMUSG00000089984.7 ENSMUSG00000089984 Fbxo24 2238 ENSMUSG00000089997.1 ENSMUSG00000089997 1810020O05Rik 2239 ENSMUSG00000090075.1 ENSMUSG00000090075 Gm16251 2240 ENSMUSG00000090098.7 ENSMUSG00000090098 Alms1-ps2 2241 ENSMUSG00000090105.2 ENSMUSG00000090105 Gm15890 2242 ENSMUSG00000090137.8 ENSMUSG00000090137 Uba52

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

2243 ENSMUSG00000090166.2 ENSMUSG00000090166 Ear10 2244 ENSMUSG00000090176.1 ENSMUSG00000090176 Cd200r2 2245 ENSMUSG00000090215.9 ENSMUSG00000090215 Trim34b 2246 ENSMUSG00000090222.2 ENSMUSG00000090222 Ifi203-ps 2247 ENSMUSG00000090266.10 ENSMUSG00000090266 Mettl23 2248 ENSMUSG00000090272.8 ENSMUSG00000090272 Mndal 2249 ENSMUSG00000090399.1 ENSMUSG00000090399 Gm38399 2250 ENSMUSG00000090516.1 ENSMUSG00000090516 Rps11-ps1 2251 ENSMUSG00000090553.8 ENSMUSG00000090553 Snrpe 2252 ENSMUSG00000090561.2 ENSMUSG00000090561 Gm17207 2253 ENSMUSG00000090622.1 ENSMUSG00000090622 A930033H14Rik 2254 ENSMUSG00000090891.3 ENSMUSG00000090891 D6Ertd527e 2255 ENSMUSG00000090952.2 ENSMUSG00000090952 Gm17251 2256 ENSMUSG00000091020.3 ENSMUSG00000091020 Gm5828 2257 ENSMUSG00000091275.1 ENSMUSG00000091275 Gm3248 2258 ENSMUSG00000091345.9 ENSMUSG00000091345 Col6a5 2259 ENSMUSG00000091373.4 ENSMUSG00000091373 Gm8810 2260 ENSMUSG00000091383.2 ENSMUSG00000091383 Hist1h2al 2261 ENSMUSG00000091405.2 ENSMUSG00000091405 Hist2h4 2262 ENSMUSG00000091408.3 ENSMUSG00000091408 Gm6728 2263 ENSMUSG00000091472.2 ENSMUSG00000091472 Gm3739 2264 ENSMUSG00000091476.6 ENSMUSG00000091476 Catspere2 2265 ENSMUSG00000091491.2 ENSMUSG00000091491 Vmn2r97 2266 ENSMUSG00000091537.2 ENSMUSG00000091537 Tma7 2267 ENSMUSG00000091549.1 ENSMUSG00000091549 Gm6548 2268 ENSMUSG00000091575.2 ENSMUSG00000091575 2010016I18Rik 2269 ENSMUSG00000091606.2 ENSMUSG00000091606 Ighv2-1 2270 ENSMUSG00000091679.9 ENSMUSG00000091679 Vmn2r96 2271 ENSMUSG00000091697.1 ENSMUSG00000091697 Eif3s6-ps2 2272 ENSMUSG00000091705.8 ENSMUSG00000091705 H2-Q2 2273 ENSMUSG00000091712.2 ENSMUSG00000091712 Sec14l5 2274 ENSMUSG00000091754.8 ENSMUSG00000091754 Gm3636 2275 ENSMUSG00000091800.2 ENSMUSG00000091800 Igkv1-115 2276 ENSMUSG00000091866.1 ENSMUSG00000091866 Gm6257 2277 ENSMUSG00000092083.4 ENSMUSG00000092083 Kcnb2 2278 ENSMUSG00000092097.1 ENSMUSG00000092097 Gm5819 2279 ENSMUSG00000092167.8 ENSMUSG00000092167 Gm3696 2280 ENSMUSG00000092183.1 ENSMUSG00000092183 4930515G01Rik 2281 ENSMUSG00000092202.1 ENSMUSG00000092202 Stk19-ps1 2282 ENSMUSG00000092216.3 ENSMUSG00000092216 Gm19345 2283 ENSMUSG00000092222.1 ENSMUSG00000092222 Gm20506 2284 ENSMUSG00000092253.1 ENSMUSG00000092253 H2-Q3 2285 ENSMUSG00000092261.1 ENSMUSG00000092261 Gm20519 2286 ENSMUSG00000092265.2 ENSMUSG00000092265 Gm5682 2287 ENSMUSG00000092278.1 ENSMUSG00000092278 Gm8752 2288 ENSMUSG00000092289.1 ENSMUSG00000092289 Gm6659 2289 ENSMUSG00000092305.1 ENSMUSG00000092305 Prps1l1 2290 ENSMUSG00000092335.1 ENSMUSG00000092335 Zfp977 2291 ENSMUSG00000092341.2 ENSMUSG00000092341 Malat1 2292 ENSMUSG00000092349.1 ENSMUSG00000092349 Platr17 2293 ENSMUSG00000092402.1 ENSMUSG00000092402 Gm20485

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

2294 ENSMUSG00000092416.2 ENSMUSG00000092416 Zfp141 2295 ENSMUSG00000092438.1 ENSMUSG00000092438 Gm18734 2296 ENSMUSG00000092444.1 ENSMUSG00000092444 Gm18733 2297 ENSMUSG00000092457.3 ENSMUSG00000092457 Gm8835 2298 ENSMUSG00000092564.1 ENSMUSG00000092564 BC051226 2299 ENSMUSG00000092591.1 ENSMUSG00000092591 Gm20429 2300 ENSMUSG00000092596.1 ENSMUSG00000092596 Gm20490 2301 ENSMUSG00000092607.9 ENSMUSG00000092607 Scnm1 2302 ENSMUSG00000093394.1 ENSMUSG00000093394 Gm20621 2303 ENSMUSG00000093445.7 ENSMUSG00000093445 Lrch4 2304 ENSMUSG00000093483.1 ENSMUSG00000093483 AA465934 2305 ENSMUSG00000093559.1 ENSMUSG00000093559 Gm20705 2306 ENSMUSG00000093565.1 ENSMUSG00000093565 Rab26os 2307 ENSMUSG00000093861.2 ENSMUSG00000093861 Igkv1-110 2308 ENSMUSG00000093880.3 ENSMUSG00000093880 Tmem181c-ps 2309 ENSMUSG00000093894.1 ENSMUSG00000093894 Ighv1-53 2310 ENSMUSG00000093896.2 ENSMUSG00000093896 Ighv1-76 2311 ENSMUSG00000093906.5 ENSMUSG00000093906 Igkv9-129 2312 ENSMUSG00000093955.2 ENSMUSG00000093955 Ighv1-34 2313 ENSMUSG00000093979.8 ENSMUSG00000093979 Gm2237 2314 ENSMUSG00000094006.2 ENSMUSG00000094006 Igkv4-59 2315 ENSMUSG00000094016.2 ENSMUSG00000094016 Trav15-1-dv6-1 2316 ENSMUSG00000094029.2 ENSMUSG00000094029 Ighv3-3 2317 ENSMUSG00000094075.1 ENSMUSG00000094075 Ighv1-80 2318 ENSMUSG00000094088.2 ENSMUSG00000094088 Ighv1-64 2319 ENSMUSG00000094091.3 ENSMUSG00000094091 Gm21885 2320 ENSMUSG00000094094.2 ENSMUSG00000094094 Igkv5-45 2321 ENSMUSG00000094102.1 ENSMUSG00000094102 Ighv9-2 2322 ENSMUSG00000094117.1 ENSMUSG00000094117 Igkv3-12 2323 ENSMUSG00000094124.5 ENSMUSG00000094124 Ighv1-74 2324 ENSMUSG00000094152.5 ENSMUSG00000094152 Slc6a16 2325 ENSMUSG00000094164.2 ENSMUSG00000094164 Ighv2-3 2326 ENSMUSG00000094194.2 ENSMUSG00000094194 Ighv5-16 2327 ENSMUSG00000094198.2 ENSMUSG00000094198 Ighv1-50 2328 ENSMUSG00000094257.2 ENSMUSG00000094257 Ap3s1-ps2 2329 ENSMUSG00000094315.2 ENSMUSG00000094315 Igkv4-78 2330 ENSMUSG00000094319.2 ENSMUSG00000094319 Igkv4-54 2331 ENSMUSG00000094322.2 ENSMUSG00000094322 Ighv9-4 2332 ENSMUSG00000094335.2 ENSMUSG00000094335 Igkv1-117 2333 ENSMUSG00000094344.1 ENSMUSG00000094344 Gm11942 2334 ENSMUSG00000094356.2 ENSMUSG00000094356 Igkv8-28 2335 ENSMUSG00000094433.2 ENSMUSG00000094433 Igkv5-43 2336 ENSMUSG00000094447.2 ENSMUSG00000094447 9430069I07Rik 2337 ENSMUSG00000094491.2 ENSMUSG00000094491 Igkv1-133 2338 ENSMUSG00000094497.1 ENSMUSG00000094497 Gm8210 2339 ENSMUSG00000094530.2 ENSMUSG00000094530 Gm21399 2340 ENSMUSG00000094533.1 ENSMUSG00000094533 Ighv11-1 2341 ENSMUSG00000094634.8 ENSMUSG00000094634 Gm3468 2342 ENSMUSG00000094649.1 ENSMUSG00000094649 Gm7102 2343 ENSMUSG00000094652.2 ENSMUSG00000094652 Ighv1-42 2344 ENSMUSG00000094685.2 ENSMUSG00000094685 Gm5900

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

2345 ENSMUSG00000094694.6 ENSMUSG00000094694 Ighv1-9 2346 ENSMUSG00000094797.1 ENSMUSG00000094797 Igkv6-15 2347 ENSMUSG00000094828.5 ENSMUSG00000094828 Trav3-3 2348 ENSMUSG00000094862.2 ENSMUSG00000094862 Ighv1-56 2349 ENSMUSG00000094872.1 ENSMUSG00000094872 Igkv9-120 2350 ENSMUSG00000094910.1 ENSMUSG00000094910 D430019H16Rik 2351 ENSMUSG00000094930.2 ENSMUSG00000094930 Igkv6-25 2352 ENSMUSG00000094940.1 ENSMUSG00000094940 Ighv1-84 2353 ENSMUSG00000094942.7 ENSMUSG00000094942 Gm3604 2354 ENSMUSG00000094951.1 ENSMUSG00000094951 Ighv5-6 2355 ENSMUSG00000094993.2 ENSMUSG00000094993 Igkv4-51 2356 ENSMUSG00000095007.1 ENSMUSG00000095007 Igkv12-41 2357 ENSMUSG00000095054.1 ENSMUSG00000095054 Gm13146 2358 ENSMUSG00000095127.2 ENSMUSG00000095127 Ighv1-82 2359 ENSMUSG00000095170.2 ENSMUSG00000095170 Ighv8-11 2360 ENSMUSG00000095174.1 ENSMUSG00000095174 Gm20069 2361 ENSMUSG00000095200.2 ENSMUSG00000095200 Ighv1-7 2362 ENSMUSG00000095204.6 ENSMUSG00000095204 Ighv1-52 2363 ENSMUSG00000095285.2 ENSMUSG00000095285 Ighv5-9 2364 ENSMUSG00000095335.2 ENSMUSG00000095335 Igkv3-5 2365 ENSMUSG00000095338.1 ENSMUSG00000095338 Igkv3-9 2366 ENSMUSG00000095351.2 ENSMUSG00000095351 Igkv3-2 2367 ENSMUSG00000095403.8 ENSMUSG00000095403 Gm21092 2368 ENSMUSG00000095416.6 ENSMUSG00000095416 Ighv1-12 2369 ENSMUSG00000095429.1 ENSMUSG00000095429 Ighv5-12 2370 ENSMUSG00000095440.2 ENSMUSG00000095440 Fignl2 2371 ENSMUSG00000095442.1 ENSMUSG00000095442 Ighv1-4 2372 ENSMUSG00000095497.2 ENSMUSG00000095497 Igkv1-122 2373 ENSMUSG00000095519.2 ENSMUSG00000095519 Ighv1-66 2374 ENSMUSG00000095565.2 ENSMUSG00000095565 Ighv2-9-1 2375 ENSMUSG00000095571.2 ENSMUSG00000095571 Ighv5-17 2376 ENSMUSG00000095583.1 ENSMUSG00000095583 Ighv14-2 2377 ENSMUSG00000095597.2 ENSMUSG00000095597 Gm6472 2378 ENSMUSG00000095612.2 ENSMUSG00000095612 Ighv5-4 2379 ENSMUSG00000095630.2 ENSMUSG00000095630 Igkv6-23 2380 ENSMUSG00000095642.3 ENSMUSG00000095642 Ighv14-3 2381 ENSMUSG00000095661.1 ENSMUSG00000095661 Gm8935 2382 ENSMUSG00000095668.1 ENSMUSG00000095668 Trbd1 2383 ENSMUSG00000095682.1 ENSMUSG00000095682 Igkv3-1 2384 ENSMUSG00000095700.2 ENSMUSG00000095700 Ighv10-3 2385 ENSMUSG00000095737.5 ENSMUSG00000095737 Igkv11-125 2386 ENSMUSG00000095753.2 ENSMUSG00000095753 Igkv4-53 2387 ENSMUSG00000095761.6 ENSMUSG00000095761 Ighv1-20 2388 ENSMUSG00000095771.2 ENSMUSG00000095771 Igkv14-111 2389 ENSMUSG00000095794.2 ENSMUSG00000095794 Igkv6-17 2390 ENSMUSG00000095859.2 ENSMUSG00000095859 Ighv1-43 2391 ENSMUSG00000095866.1 ENSMUSG00000095866 Ighv2-4 2392 ENSMUSG00000095923.6 ENSMUSG00000095923 Ighv1-37 2393 ENSMUSG00000095930.1 ENSMUSG00000095930 Nim1k 2394 ENSMUSG00000095981.1 ENSMUSG00000095981 Ighv10-1 2395 ENSMUSG00000096020.2 ENSMUSG00000096020 Ighv1-75

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

2396 ENSMUSG00000096074.2 ENSMUSG00000096074 Ighv1-72 2397 ENSMUSG00000096078.2 ENSMUSG00000096078 Ighv1-62-2 2398 ENSMUSG00000096150.1 ENSMUSG00000096150 Ighv1-85 2399 ENSMUSG00000096157.2 ENSMUSG00000096157 Gm5472 2400 ENSMUSG00000096176.1 ENSMUSG00000096176 Trdd2 2401 ENSMUSG00000096233.1 ENSMUSG00000096233 Gm13238 2402 ENSMUSG00000096255.2 ENSMUSG00000096255 Dynlt1b 2403 ENSMUSG00000096326.2 ENSMUSG00000096326 Ighv1-78 2404 ENSMUSG00000096336.2 ENSMUSG00000096336 Igkv1-135 2405 ENSMUSG00000096403.2 ENSMUSG00000096403 Gm9825 2406 ENSMUSG00000096407.2 ENSMUSG00000096407 Ighv6-5 2407 ENSMUSG00000096410.2 ENSMUSG00000096410 Ighv1-19 2408 ENSMUSG00000096449.2 ENSMUSG00000096449 Gm4076 2409 ENSMUSG00000096452.2 ENSMUSG00000096452 Ighv1-77 2410 ENSMUSG00000096459.1 ENSMUSG00000096459 Ighv9-3 2411 ENSMUSG00000096461.5 ENSMUSG00000096461 Igkv14-130 2412 ENSMUSG00000096464.2 ENSMUSG00000096464 Ighv2-2 2413 ENSMUSG00000096482.1 ENSMUSG00000096482 Gm23977 2414 ENSMUSG00000096490.1 ENSMUSG00000096490 Igkv10-94 2415 ENSMUSG00000096498.3 ENSMUSG00000096498 Ighv2-5 2416 ENSMUSG00000096499.2 ENSMUSG00000096499 Ighv1-5 2417 ENSMUSG00000096515.5 ENSMUSG00000096515 Igkv14-100 2418 ENSMUSG00000096580.1 ENSMUSG00000096580 Igkv1-132 2419 ENSMUSG00000096594.2 ENSMUSG00000096594 Igkv8-19 2420 ENSMUSG00000096629.7 ENSMUSG00000096629 Gm3383 2421 ENSMUSG00000096632.2 ENSMUSG00000096632 Igkv9-124 2422 ENSMUSG00000096638.2 ENSMUSG00000096638 Ighv2-9 2423 ENSMUSG00000096670.1 ENSMUSG00000096670 Ighv2-6 2424 ENSMUSG00000096672.1 ENSMUSG00000096672 Ighv1-63 2425 ENSMUSG00000096696.1 ENSMUSG00000096696 Zfp960 2426 ENSMUSG00000096755.2 ENSMUSG00000096755 Ftl1-ps2 2427 ENSMUSG00000096767.2 ENSMUSG00000096767 Ighv1-62-3 2428 ENSMUSG00000096780.7 ENSMUSG00000096780 Tmem181b-ps 2429 ENSMUSG00000096824.2 ENSMUSG00000096824 Ighv2-7 2430 ENSMUSG00000096833.2 ENSMUSG00000096833 Igkv4-55 2431 ENSMUSG00000096883.2 ENSMUSG00000096883 Shisa8 2432 ENSMUSG00000096957.1 ENSMUSG00000096957 E230013L22Rik 2433 ENSMUSG00000096979.1 ENSMUSG00000096979 Gm26880 2434 ENSMUSG00000097080.7 ENSMUSG00000097080 1700086O06Rik 2435 ENSMUSG00000097113.7 ENSMUSG00000097113 Gm19705 2436 ENSMUSG00000097155.1 ENSMUSG00000097155 Gm26511 2437 ENSMUSG00000097177.8 ENSMUSG00000097177 9330159M07Rik 2438 ENSMUSG00000097193.1 ENSMUSG00000097193 Gm26664 2439 ENSMUSG00000097230.1 ENSMUSG00000097230 Gm26853 2440 ENSMUSG00000097242.1 ENSMUSG00000097242 Gm16907 2441 ENSMUSG00000097252.1 ENSMUSG00000097252 Gm6634 2442 ENSMUSG00000097261.2 ENSMUSG00000097261 4930532G15Rik 2443 ENSMUSG00000097276.1 ENSMUSG00000097276 4930525G20Rik 2444 ENSMUSG00000097289.1 ENSMUSG00000097289 2010300F17Rik 2445 ENSMUSG00000097295.1 ENSMUSG00000097295 Hmgb1-ps8 2446 ENSMUSG00000097386.1 ENSMUSG00000097386 9130213A22Rik

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

2447 ENSMUSG00000097404.1 ENSMUSG00000097404 Gm10814 2448 ENSMUSG00000097417.1 ENSMUSG00000097417 Gm26669 2449 ENSMUSG00000097431.2 ENSMUSG00000097431 Gm26782 2450 ENSMUSG00000097443.2 ENSMUSG00000097443 Gm17529 2451 ENSMUSG00000097451.10 ENSMUSG00000097451 Rian 2452 ENSMUSG00000097472.1 ENSMUSG00000097472 Gm26586 2453 ENSMUSG00000097476.1 ENSMUSG00000097476 Gm26583 2454 ENSMUSG00000097489.1 ENSMUSG00000097489 Gm26808 2455 ENSMUSG00000097544.1 ENSMUSG00000097544 Gm26750 2456 ENSMUSG00000097554.1 ENSMUSG00000097554 Gm26825 2457 ENSMUSG00000097567.1 ENSMUSG00000097567 Gm26637 2458 ENSMUSG00000097572.2 ENSMUSG00000097572 Gm26797 2459 ENSMUSG00000097574.1 ENSMUSG00000097574 C920006O11Rik 2460 ENSMUSG00000097584.1 ENSMUSG00000097584 1700125G22Rik 2461 ENSMUSG00000097616.7 ENSMUSG00000097616 1110019D14Rik 2462 ENSMUSG00000097643.1 ENSMUSG00000097643 A130051J06Rik 2463 ENSMUSG00000097644.1 ENSMUSG00000097644 Gm26862 2464 ENSMUSG00000097662.1 ENSMUSG00000097662 Gm2093 2465 ENSMUSG00000097705.1 ENSMUSG00000097705 Gm26740 2466 ENSMUSG00000097713.1 ENSMUSG00000097713 Gm7741 2467 ENSMUSG00000097785.1 ENSMUSG00000097785 B230217O12Rik 2468 ENSMUSG00000097812.1 ENSMUSG00000097812 Gm26812 2469 ENSMUSG00000097818.1 ENSMUSG00000097818 Gm26681 2470 ENSMUSG00000097825.5 ENSMUSG00000097825 9630001P10Rik 2471 ENSMUSG00000097860.1 ENSMUSG00000097860 Gm26857 2472 ENSMUSG00000097863.1 ENSMUSG00000097863 1010001B22Rik 2473 ENSMUSG00000097886.2 ENSMUSG00000097886 Gsg1l2 2474 ENSMUSG00000097891.1 ENSMUSG00000097891 Gm3650 2475 ENSMUSG00000097902.2 ENSMUSG00000097902 Gm26531 2476 ENSMUSG00000097906.1 ENSMUSG00000097906 Gm9625 2477 ENSMUSG00000097908.7 ENSMUSG00000097908 4933404O12Rik 2478 ENSMUSG00000097924.2 ENSMUSG00000097924 A730020E08Rik 2479 ENSMUSG00000097960.1 ENSMUSG00000097960 A330074K22Rik 2480 ENSMUSG00000097990.1 ENSMUSG00000097990 Gm19557 2481 ENSMUSG00000097993.7 ENSMUSG00000097993 Ptprv 2482 ENSMUSG00000098000.1 ENSMUSG00000098000 Gm27026 2483 ENSMUSG00000098021.2 ENSMUSG00000098021 Gm9522 2484 ENSMUSG00000098022.7 ENSMUSG00000098022 Zfp82 2485 ENSMUSG00000098090.7 ENSMUSG00000098090 2700099C18Rik 2486 ENSMUSG00000098188.1 ENSMUSG00000098188 Sowahc 2487 ENSMUSG00000098197.1 ENSMUSG00000098197 BC051537 2488 ENSMUSG00000098241.1 ENSMUSG00000098241 H2-Pa 2489 ENSMUSG00000098318.7 ENSMUSG00000098318 Lockd 2490 ENSMUSG00000098322.1 ENSMUSG00000098322 5830468F06Rik 2491 ENSMUSG00000098552.1 ENSMUSG00000098552 Gm27217 2492 ENSMUSG00000098814.2 ENSMUSG00000098814 Igkv19-93 2493 ENSMUSG00000098900.2 ENSMUSG00000098900 Gm18190 2494 ENSMUSG00000098934.1 ENSMUSG00000098934 Gm18853 2495 ENSMUSG00000099032.2 ENSMUSG00000099032 Tcf24 2496 ENSMUSG00000099216.1 ENSMUSG00000099216 Obox8 2497 ENSMUSG00000099342.1 ENSMUSG00000099342 Gm18180

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

2498 ENSMUSG00000099397.1 ENSMUSG00000099397 Gm7809 2499 ENSMUSG00000099470.1 ENSMUSG00000099470 Gm29340 2500 ENSMUSG00000099655.2 ENSMUSG00000099655 2310034G01Rik 2501 ENSMUSG00000099703.6 ENSMUSG00000099703 Gm28285 2502 ENSMUSG00000099759.1 ENSMUSG00000099759 1700030C10Rik 2503 ENSMUSG00000099767.1 ENSMUSG00000099767 Gm28884 2504 ENSMUSG00000099775.1 ENSMUSG00000099775 Gm5960 2505 ENSMUSG00000099968.7 ENSMUSG00000099968 1700029J03Rik 2506 ENSMUSG00000100150.2 ENSMUSG00000100150 Gm19585 2507 ENSMUSG00000100182.6 ENSMUSG00000100182 1810006J02Rik 2508 ENSMUSG00000100215.1 ENSMUSG00000100215 Gm8292 2509 ENSMUSG00000100235.8 ENSMUSG00000100235 Gm28557 2510 ENSMUSG00000100277.8 ENSMUSG00000100277 1810053B23Rik 2511 ENSMUSG00000100490.1 ENSMUSG00000100490 Gm28455 2512 ENSMUSG00000100594.1 ENSMUSG00000100594 2810414N06Rik 2513 ENSMUSG00000100620.1 ENSMUSG00000100620 Gm28277 2514 ENSMUSG00000100658.1 ENSMUSG00000100658 F730311O21Rik 2515 ENSMUSG00000100680.1 ENSMUSG00000100680 1810044D09Rik 2516 ENSMUSG00000101316.1 ENSMUSG00000101316 Gm12663 2517 ENSMUSG00000101344.1 ENSMUSG00000101344 Gm29183 2518 ENSMUSG00000101389.1 ENSMUSG00000101389 Ms4a4a 2519 ENSMUSG00000101392.1 ENSMUSG00000101392 Gm29163 2520 ENSMUSG00000101431.1 ENSMUSG00000101431 Gm7901 2521 ENSMUSG00000101462.2 ENSMUSG00000101462 Gm3052 2522 ENSMUSG00000101523.1 ENSMUSG00000101523 Gm10031 2523 ENSMUSG00000101739.1 ENSMUSG00000101739 Gm5733 2524 ENSMUSG00000101939.1 ENSMUSG00000101939 Gm28438 2525 ENSMUSG00000102037.1 ENSMUSG00000102037 Bcl2a1a 2526 ENSMUSG00000102162.1 ENSMUSG00000102162 Gm2367 2527 ENSMUSG00000102246.1 ENSMUSG00000102246 9430037O13Rik 2528 ENSMUSG00000102252.5 ENSMUSG00000102252 Snrpn 2529 ENSMUSG00000102275.1 ENSMUSG00000102275 Gm37144 2530 ENSMUSG00000102278.1 ENSMUSG00000102278 Gm37145 2531 ENSMUSG00000102281.1 ENSMUSG00000102281 Ighv1-30 2532 ENSMUSG00000102286.1 ENSMUSG00000102286 Gm37004 2533 ENSMUSG00000102301.1 ENSMUSG00000102301 Ighv8-2 2534 ENSMUSG00000102315.1 ENSMUSG00000102315 Ighv1-28 2535 ENSMUSG00000102364.1 ENSMUSG00000102364 Ighv8-5 2536 ENSMUSG00000102418.1 ENSMUSG00000102418 Sh2d1b1 2537 ENSMUSG00000102461.1 ENSMUSG00000102461 Gm37166 2538 ENSMUSG00000102483.1 ENSMUSG00000102483 Catspere1 2539 ENSMUSG00000102493.1 ENSMUSG00000102493 Gm8010 2540 ENSMUSG00000102512.1 ENSMUSG00000102512 Ighv1-29 2541 ENSMUSG00000102543.5 ENSMUSG00000102543 Pcdhgc5 2542 ENSMUSG00000102544.1 ENSMUSG00000102544 Gm5103 2543 ENSMUSG00000102654.1 ENSMUSG00000102654 Ighv1-21 2544 ENSMUSG00000102656.1 ENSMUSG00000102656 Ighv1-32 2545 ENSMUSG00000102678.1 ENSMUSG00000102678 Ighv1-21-1 2546 ENSMUSG00000102717.1 ENSMUSG00000102717 Gm37759 2547 ENSMUSG00000102752.1 ENSMUSG00000102752 Gm7694 2548 ENSMUSG00000102765.1 ENSMUSG00000102765 Ighv1-62

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

2549 ENSMUSG00000102780.1 ENSMUSG00000102780 Gm38253 2550 ENSMUSG00000102824.1 ENSMUSG00000102824 Pdcd5-ps 2551 ENSMUSG00000102833.1 ENSMUSG00000102833 Gm9694 2552 ENSMUSG00000102882.1 ENSMUSG00000102882 Gm2065 2553 ENSMUSG00000102901.1 ENSMUSG00000102901 Ighv5-1 2554 ENSMUSG00000102923.1 ENSMUSG00000102923 Gm31728 2555 ENSMUSG00000102942.1 ENSMUSG00000102942 Ighv1-33 2556 ENSMUSG00000102952.1 ENSMUSG00000102952 Ighv1-25 2557 ENSMUSG00000102991.1 ENSMUSG00000102991 Ighv1-40 2558 ENSMUSG00000103032.1 ENSMUSG00000103032 Gm37121 2559 ENSMUSG00000103033.1 ENSMUSG00000103033 Ighv5-12-4 2560 ENSMUSG00000103088.1 ENSMUSG00000103088 Pcdhgb6 2561 ENSMUSG00000103126.2 ENSMUSG00000103126 Gm37387 2562 ENSMUSG00000103164.1 ENSMUSG00000103164 Gm38150 2563 ENSMUSG00000103168.1 ENSMUSG00000103168 Gm30948 2564 ENSMUSG00000103170.1 ENSMUSG00000103170 Gm37170 2565 ENSMUSG00000103175.1 ENSMUSG00000103175 Gm37169 2566 ENSMUSG00000103260.1 ENSMUSG00000103260 Gm8146 2567 ENSMUSG00000103271.1 ENSMUSG00000103271 Ighv4-2 2568 ENSMUSG00000103290.1 ENSMUSG00000103290 Ighv1-23 2569 ENSMUSG00000103297.1 ENSMUSG00000103297 Ighv3-2 2570 ENSMUSG00000103357.1 ENSMUSG00000103357 Gm7804 2571 ENSMUSG00000103395.1 ENSMUSG00000103395 Ighv1-27 2572 ENSMUSG00000103409.1 ENSMUSG00000103409 Lsmem2 2573 ENSMUSG00000103452.1 ENSMUSG00000103452 1700008A23Rik 2574 ENSMUSG00000103527.1 ENSMUSG00000103527 Gm37261 2575 ENSMUSG00000103540.1 ENSMUSG00000103540 Gm37668 2576 ENSMUSG00000103543.1 ENSMUSG00000103543 Gm37669 2577 ENSMUSG00000103586.5 ENSMUSG00000103586 5830405F06Rik 2578 ENSMUSG00000103588.1 ENSMUSG00000103588 Gm18445 2579 ENSMUSG00000103593.1 ENSMUSG00000103593 Gm37352 2580 ENSMUSG00000103706.1 ENSMUSG00000103706 6820402A03Rik 2581 ENSMUSG00000103788.1 ENSMUSG00000103788 Gm37527 2582 ENSMUSG00000103790.1 ENSMUSG00000103790 Ighv1-17 2583 ENSMUSG00000103847.1 ENSMUSG00000103847 Gm20056 2584 ENSMUSG00000103873.1 ENSMUSG00000103873 Ighv1-38 2585 ENSMUSG00000103939.1 ENSMUSG00000103939 Ighv3-4 2586 ENSMUSG00000104117.5 ENSMUSG00000104117 Gm20743 2587 ENSMUSG00000104157.1 ENSMUSG00000104157 Gm38101 2588 ENSMUSG00000104222.1 ENSMUSG00000104222 Gm7292 2589 ENSMUSG00000104363.1 ENSMUSG00000104363 Gm38081 2590 ENSMUSG00000104422.1 ENSMUSG00000104422 Ighv1-14 2591 ENSMUSG00000104436.1 ENSMUSG00000104436 Gm37423 2592 ENSMUSG00000104452.1 ENSMUSG00000104452 Ighv8-8 2593 ENSMUSG00000104517.1 ENSMUSG00000104517 Gm18407 2594 ENSMUSG00000104554.1 ENSMUSG00000104554 Gm4610 2595 ENSMUSG00000104590.2 ENSMUSG00000104590 Gm5034 2596 ENSMUSG00000104623.1 ENSMUSG00000104623 Gm6394 2597 ENSMUSG00000104650.1 ENSMUSG00000104650 Trav22 2598 ENSMUSG00000104658.4 ENSMUSG00000104658 Gm30275 2599 ENSMUSG00000104679.1 ENSMUSG00000104679 Igkv4-60

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

2600 ENSMUSG00000104682.1 ENSMUSG00000104682 Gm42636 2601 ENSMUSG00000104742.1 ENSMUSG00000104742 Igkv9-128 2602 ENSMUSG00000104802.1 ENSMUSG00000104802 Gm5869 2603 ENSMUSG00000104837.1 ENSMUSG00000104837 Gm42520 2604 ENSMUSG00000104876.1 ENSMUSG00000104876 Trdc 2605 ENSMUSG00000104927.1 ENSMUSG00000104927 Gm43388 2606 ENSMUSG00000104969.1 ENSMUSG00000104969 Gm43445 2607 ENSMUSG00000105005.1 ENSMUSG00000105005 Gm9729 2608 ENSMUSG00000105043.1 ENSMUSG00000105043 Igkv1-108 2609 ENSMUSG00000105096.1 ENSMUSG00000105096 Gbp10 2610 ENSMUSG00000105111.1 ENSMUSG00000105111 Gm43310 2611 ENSMUSG00000105128.1 ENSMUSG00000105128 Gm42870 2612 ENSMUSG00000105160.1 ENSMUSG00000105160 A530030E21Rik 2613 ENSMUSG00000105228.1 ENSMUSG00000105228 Gm43340 2614 ENSMUSG00000105231.1 ENSMUSG00000105231 Iglj3 2615 ENSMUSG00000105233.1 ENSMUSG00000105233 Gm20568 2616 ENSMUSG00000105296.1 ENSMUSG00000105296 Gm19708 2617 ENSMUSG00000105402.4 ENSMUSG00000105402 Gm3716 2618 ENSMUSG00000105408.1 ENSMUSG00000105408 Gm7285 2619 ENSMUSG00000105461.1 ENSMUSG00000105461 Gm4742 2620 ENSMUSG00000105462.1 ENSMUSG00000105462 Igkv4-77 2621 ENSMUSG00000105506.1 ENSMUSG00000105506 Gm43743 2622 ENSMUSG00000105510.1 ENSMUSG00000105510 Gm43815 2623 ENSMUSG00000105547.1 ENSMUSG00000105547 Iglc3 2624 ENSMUSG00000105558.1 ENSMUSG00000105558 Gm5855 2625 ENSMUSG00000105605.1 ENSMUSG00000105605 Ighv1-86 2626 ENSMUSG00000105606.1 ENSMUSG00000105606 Igkv2-109 2627 ENSMUSG00000105613.1 ENSMUSG00000105613 Gm43684 2628 ENSMUSG00000105646.1 ENSMUSG00000105646 Gm30211 2629 ENSMUSG00000105652.1 ENSMUSG00000105652 4930519L02Rik 2630 ENSMUSG00000105703.2 ENSMUSG00000105703 Gm43305 2631 ENSMUSG00000105757.1 ENSMUSG00000105757 Ighv1-83 2632 ENSMUSG00000105776.1 ENSMUSG00000105776 Gm43292 2633 ENSMUSG00000105830.1 ENSMUSG00000105830 Trgj2 2634 ENSMUSG00000105842.1 ENSMUSG00000105842 Gm43329 2635 ENSMUSG00000105852.4 ENSMUSG00000105852 Gm42890 2636 ENSMUSG00000105906.1 ENSMUSG00000105906 Iglc1 2637 ENSMUSG00000105987.4 ENSMUSG00000105987 AI506816 2638 ENSMUSG00000106028.1 ENSMUSG00000106028 Gm8493 2639 ENSMUSG00000106041.1 ENSMUSG00000106041 Olfr241-ps1 2640 ENSMUSG00000106073.1 ENSMUSG00000106073 Gm42892 2641 ENSMUSG00000106112.1 ENSMUSG00000106112 Gm43434 2642 ENSMUSG00000106219.1 ENSMUSG00000106219 5830416I19Rik 2643 ENSMUSG00000106229.1 ENSMUSG00000106229 Gm19409 2644 ENSMUSG00000106294.1 ENSMUSG00000106294 Gm8539 2645 ENSMUSG00000106380.1 ENSMUSG00000106380 Gm3519 2646 ENSMUSG00000106387.1 ENSMUSG00000106387 Igkv4-73 2647 ENSMUSG00000106403.1 ENSMUSG00000106403 Igkv20-101-2 2648 ENSMUSG00000106405.1 ENSMUSG00000106405 Iglj3p 2649 ENSMUSG00000106434.1 ENSMUSG00000106434 Gm42990 2650 ENSMUSG00000106457.1 ENSMUSG00000106457 Gm42585

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

2651 ENSMUSG00000106599.1 ENSMUSG00000106599 Ighv1-73 2652 ENSMUSG00000106601.1 ENSMUSG00000106601 Ighv1-70 2653 ENSMUSG00000106617.1 ENSMUSG00000106617 Gm36266 2654 ENSMUSG00000106630.1 ENSMUSG00000106630 Igkv2-116 2655 ENSMUSG00000106641.1 ENSMUSG00000106641 Gm43534 2656 ENSMUSG00000106668.1 ENSMUSG00000106668 Iglj1 2657 ENSMUSG00000106820.1 ENSMUSG00000106820 D5Ertd605e 2658 ENSMUSG00000106874.1 ENSMUSG00000106874 Gm20186 2659 ENSMUSG00000106939.1 ENSMUSG00000106939 Gm29778 2660 ENSMUSG00000107017.1 ENSMUSG00000107017 Gm43196 2661 ENSMUSG00000107061.1 ENSMUSG00000107061 Gm19590 2662 ENSMUSG00000107086.1 ENSMUSG00000107086 Gm43808 2663 ENSMUSG00000107310.1 ENSMUSG00000107310 Gm7452 2664 ENSMUSG00000107327.1 ENSMUSG00000107327 Gm7478 2665 ENSMUSG00000107331.1 ENSMUSG00000107331 Gm42732 2666 ENSMUSG00000107470.1 ENSMUSG00000107470 Gm3375 2667 ENSMUSG00000107619.1 ENSMUSG00000107619 Gm32479 2668 ENSMUSG00000107715.1 ENSMUSG00000107715 Gm44135 2669 ENSMUSG00000107881.1 ENSMUSG00000107881 Gm44250 2670 ENSMUSG00000107899.1 ENSMUSG00000107899 Gm44069 2671 ENSMUSG00000108053.1 ENSMUSG00000108053 Gm43890 2672 ENSMUSG00000108068.1 ENSMUSG00000108068 Gm44075 2673 ENSMUSG00000108079.1 ENSMUSG00000108079 Gm44210 2674 ENSMUSG00000108126.1 ENSMUSG00000108126 Gm43909 2675 ENSMUSG00000108234.1 ENSMUSG00000108234 Gm44428 2676 ENSMUSG00000108239.1 ENSMUSG00000108239 Gm19434 2677 ENSMUSG00000108291.1 ENSMUSG00000108291 Gm44292 2678 ENSMUSG00000108352.1 ENSMUSG00000108352 Usf2-ps1 2679 ENSMUSG00000108353.1 ENSMUSG00000108353 Gm45205 2680 ENSMUSG00000108360.1 ENSMUSG00000108360 Gm36159 2681 ENSMUSG00000108389.1 ENSMUSG00000108389 Gm45206 2682 ENSMUSG00000108396.1 ENSMUSG00000108396 Gm6905 2683 ENSMUSG00000108405.1 ENSMUSG00000108405 Ywhaq-ps1 2684 ENSMUSG00000108518.1 ENSMUSG00000108518 Gm5587 2685 ENSMUSG00000108555.1 ENSMUSG00000108555 Gm18310 2686 ENSMUSG00000108601.1 ENSMUSG00000108601 Gm44645 2687 ENSMUSG00000108608.1 ENSMUSG00000108608 Gm6916 2688 ENSMUSG00000108643.1 ENSMUSG00000108643 Gm44931 2689 ENSMUSG00000108659.1 ENSMUSG00000108659 Gm34121 2690 ENSMUSG00000108709.1 ENSMUSG00000108709 4933431G14Rik 2691 ENSMUSG00000108732.1 ENSMUSG00000108732 2310043P16Rik 2692 ENSMUSG00000108866.1 ENSMUSG00000108866 Gm35082 2693 ENSMUSG00000108930.1 ENSMUSG00000108930 Gm10648 2694 ENSMUSG00000109122.1 ENSMUSG00000109122 A230103L15Rik 2695 ENSMUSG00000109123.1 ENSMUSG00000109123 Gm39059 2696 ENSMUSG00000109176.1 ENSMUSG00000109176 Zfp264 2697 ENSMUSG00000109198.1 ENSMUSG00000109198 D7Bwg0826e 2698 ENSMUSG00000109209.1 ENSMUSG00000109209 Gm45104 2699 ENSMUSG00000109214.1 ENSMUSG00000109214 Gm44659 2700 ENSMUSG00000109244.1 ENSMUSG00000109244 Gm44751 2701 ENSMUSG00000109245.1 ENSMUSG00000109245 Gm44860

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

2702 ENSMUSG00000109291.1 ENSMUSG00000109291 Gm2814 2703 ENSMUSG00000109324.2 ENSMUSG00000109324 Prmt1 2704 ENSMUSG00000109602.1 ENSMUSG00000109602 Gm31597 2705 ENSMUSG00000109644.1 ENSMUSG00000109644 0610005C13Rik 2706 ENSMUSG00000109645.1 ENSMUSG00000109645 Gm45246 2707 ENSMUSG00000109675.2 ENSMUSG00000109675 Nxpe1-ps 2708 ENSMUSG00000109713.1 ENSMUSG00000109713 Pvrig 2709 ENSMUSG00000109714.1 ENSMUSG00000109714 Gm35021 2710 ENSMUSG00000109719.1 ENSMUSG00000109719 Gm45266 2711 ENSMUSG00000109751.1 ENSMUSG00000109751 Gm45479 2712 ENSMUSG00000109765.2 ENSMUSG00000109765 Gm18227 2713 ENSMUSG00000109787.1 ENSMUSG00000109787 Gm45286 2714 ENSMUSG00000109812.1 ENSMUSG00000109812 Gm45640 2715 ENSMUSG00000109998.1 ENSMUSG00000109998 Gm45437 2716 ENSMUSG00000110027.1 ENSMUSG00000110027 C030029H02Rik 2717 ENSMUSG00000110105.1 ENSMUSG00000110105 Gm45844 2718 ENSMUSG00000110126.1 ENSMUSG00000110126 Gm9347 2719 ENSMUSG00000110170.1 ENSMUSG00000110170 St6galnac2 2720 ENSMUSG00000110239.1 ENSMUSG00000110239 Gm45620 2721 ENSMUSG00000110245.1 ENSMUSG00000110245 Gm20100 2722 ENSMUSG00000110279.1 ENSMUSG00000110279 Gm45552 2723 ENSMUSG00000110298.1 ENSMUSG00000110298 Gm8189 2724 ENSMUSG00000110331.1 ENSMUSG00000110331 Nudc-ps1 2725 ENSMUSG00000110357.1 ENSMUSG00000110357 A030001D20Rik 2726 ENSMUSG00000110386.1 ENSMUSG00000110386 Gm42031 2727 ENSMUSG00000110419.1 ENSMUSG00000110419 AW046200 2728 ENSMUSG00000110426.1 ENSMUSG00000110426 Gm45757 2729 ENSMUSG00000110458.1 ENSMUSG00000110458 Gm21769 2730 ENSMUSG00000110498.1 ENSMUSG00000110498 A630001O12Rik 2731 ENSMUSG00000110537.1 ENSMUSG00000110537 Gm4316 2732 ENSMUSG00000110545.1 ENSMUSG00000110545 Gm7730 2733 ENSMUSG00000110569.1 ENSMUSG00000110569 Gm18860 2734 ENSMUSG00000110588.1 ENSMUSG00000110588 Gm45774 2735 ENSMUSG00000110631.1 ENSMUSG00000110631 Gm42047 2736 ENSMUSG00000110649.1 ENSMUSG00000110649 Gm40466 2737 ENSMUSG00000110669.1 ENSMUSG00000110669 Gm10060 2738 ENSMUSG00000110692.1 ENSMUSG00000110692 Gm33460 2739 ENSMUSG00000110720.1 ENSMUSG00000110720 Gm46223 2740 ENSMUSG00000110774.1 ENSMUSG00000110774 Gm39318 2741 ENSMUSG00000111118.1 ENSMUSG00000111118 Gm6545 2742 ENSMUSG00000111189.1 ENSMUSG00000111189 Gm48293 2743 ENSMUSG00000111203.1 ENSMUSG00000111203 Gm48719 2744 ENSMUSG00000111205.1 ENSMUSG00000111205 Gm39307 2745 ENSMUSG00000111342.1 ENSMUSG00000111342 4933404K13Rik 2746 ENSMUSG00000111351.1 ENSMUSG00000111351 Gm48537 2747 ENSMUSG00000111369.1 ENSMUSG00000111369 Gm47043 2748 ENSMUSG00000111378.1 ENSMUSG00000111378 Gm47230 2749 ENSMUSG00000111481.1 ENSMUSG00000111481 Gm47652 2750 ENSMUSG00000111548.1 ENSMUSG00000111548 Gm8162 2751 ENSMUSG00000111594.1 ENSMUSG00000111594 Gm3365 2752 ENSMUSG00000111611.1 ENSMUSG00000111611 Olfr157

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

2753 ENSMUSG00000111685.1 ENSMUSG00000111685 Gm10686 2754 ENSMUSG00000111713.1 ENSMUSG00000111713 Gm20234 2755 ENSMUSG00000111834.1 ENSMUSG00000111834 Gm40020 2756 ENSMUSG00000111862.1 ENSMUSG00000111862 Gm47828 2757 ENSMUSG00000111913.1 ENSMUSG00000111913 AC153498.1 2758 ENSMUSG00000111942.1 ENSMUSG00000111942 Gm5182 2759 ENSMUSG00000111997.1 ENSMUSG00000111997 Gm5176 2760 ENSMUSG00000112003.1 ENSMUSG00000112003 Gm4864 2761 ENSMUSG00000112030.1 ENSMUSG00000112030 Gm35189 2762 ENSMUSG00000112063.1 ENSMUSG00000112063 Gm32220 2763 ENSMUSG00000112099.1 ENSMUSG00000112099 Gm8960 2764 ENSMUSG00000112109.1 ENSMUSG00000112109 Gm30906 2765 ENSMUSG00000112132.1 ENSMUSG00000112132 Gm36229 2766 ENSMUSG00000112163.1 ENSMUSG00000112163 Gm8188 2767 ENSMUSG00000112220.1 ENSMUSG00000112220 Gm36208 2768 ENSMUSG00000112226.1 ENSMUSG00000112226 Gm48786 2769 ENSMUSG00000112230.1 ENSMUSG00000112230 Ifngas1 2770 ENSMUSG00000112249.1 ENSMUSG00000112249 Gm30262 2771 ENSMUSG00000112265.1 ENSMUSG00000112265 Gm34983 2772 ENSMUSG00000112386.1 ENSMUSG00000112386 Gm47752 2773 ENSMUSG00000112458.1 ENSMUSG00000112458 Gm40773 2774 ENSMUSG00000112478.1 ENSMUSG00000112478 Gm47761 2775 ENSMUSG00000112502.1 ENSMUSG00000112502 Gm46194 2776 ENSMUSG00000112535.1 ENSMUSG00000112535 Gm47425 2777 ENSMUSG00000112640.1 ENSMUSG00000112640 Gm32687 2778 ENSMUSG00000112758.1 ENSMUSG00000112758 Gm36172 2779 ENSMUSG00000112766.1 ENSMUSG00000112766 Gm40645 2780 ENSMUSG00000112824.1 ENSMUSG00000112824 Gm47917 2781 ENSMUSG00000112836.1 ENSMUSG00000112836 Gm47006 2782 ENSMUSG00000112843.1 ENSMUSG00000112843 Gm46224 2783 ENSMUSG00000112907.1 ENSMUSG00000112907 Gm47015 2784 ENSMUSG00000112969.1 ENSMUSG00000112969 Gm48496 2785 ENSMUSG00000113035.1 ENSMUSG00000113035 5830428M24Rik 2786 ENSMUSG00000113036.1 ENSMUSG00000113036 Gm47021 2787 ENSMUSG00000113047.1 ENSMUSG00000113047 Gm47469 2788 ENSMUSG00000113078.1 ENSMUSG00000113078 Gm48734 2789 ENSMUSG00000113128.1 ENSMUSG00000113128 Gm47813 2790 ENSMUSG00000113255.1 ENSMUSG00000113255 Tes3-ps 2791 ENSMUSG00000113263.1 ENSMUSG00000113263 Gm4811 2792 ENSMUSG00000113278.1 ENSMUSG00000113278 Gm33016 2793 ENSMUSG00000113519.1 ENSMUSG00000113519 Gm47541 2794 ENSMUSG00000113535.1 ENSMUSG00000113535 AU015791 2795 ENSMUSG00000113600.1 ENSMUSG00000113600 Gm7868 2796 ENSMUSG00000113626.1 ENSMUSG00000113626 Gm7240 2797 ENSMUSG00000113707.1 ENSMUSG00000113707 Gm10457 2798 ENSMUSG00000113725.1 ENSMUSG00000113725 Gm48358 2799 ENSMUSG00000113728.1 ENSMUSG00000113728 Gm7622 2800 ENSMUSG00000113769.1 ENSMUSG00000113769 5033406O09Rik 2801 ENSMUSG00000113894.1 ENSMUSG00000113894 Gm48838 2802 ENSMUSG00000113946.1 ENSMUSG00000113946 Gm47250 2803 ENSMUSG00000113959.1 ENSMUSG00000113959 Gm46339

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

2804 ENSMUSG00000114033.1 ENSMUSG00000114033 Gm47705 2805 ENSMUSG00000114133.1 ENSMUSG00000114133 Gm20075 2806 ENSMUSG00000114141.1 ENSMUSG00000114141 Gm34215 2807 ENSMUSG00000114203.1 ENSMUSG00000114203 Gm35279 2808 ENSMUSG00000114382.1 ENSMUSG00000114382 Gm4814 2809 ENSMUSG00000114399.1 ENSMUSG00000114399 Gm47994 2810 ENSMUSG00000114422.1 ENSMUSG00000114422 Gm30411 2811 ENSMUSG00000114442.1 ENSMUSG00000114442 F630042J09Rik 2812 ENSMUSG00000114536.1 ENSMUSG00000114536 Gm48837 2813 ENSMUSG00000114568.1 ENSMUSG00000114568 Gm48732 2814 ENSMUSG00000114573.1 ENSMUSG00000114573 Gm47732 2815 ENSMUSG00000114607.1 ENSMUSG00000114607 Gm8990 2816 ENSMUSG00000114615.1 ENSMUSG00000114615 Gm48370 2817 ENSMUSG00000114665.1 ENSMUSG00000114665 Gm30918 2818 ENSMUSG00000114687.1 ENSMUSG00000114687 Gm5452 2819 ENSMUSG00000114707.1 ENSMUSG00000114707 Gm47558 2820 ENSMUSG00000114733.1 ENSMUSG00000114733 Gm4815 2821 ENSMUSG00000114766.1 ENSMUSG00000114766 Gm5203 2822 ENSMUSG00000114771.1 ENSMUSG00000114771 Gm49064 2823 ENSMUSG00000114784.1 ENSMUSG00000114784 Gm47754 2824 ENSMUSG00000114827.1 ENSMUSG00000114827 Gm46432 2825 ENSMUSG00000114968.1 ENSMUSG00000114968 A630019I02Rik 2826 ENSMUSG00000115280.1 ENSMUSG00000115280 Gm7107 2827 ENSMUSG00000115326.1 ENSMUSG00000115326 Gm35019 2828 ENSMUSG00000115388.2 ENSMUSG00000115388 Eppk1 2829 ENSMUSG00000115428.1 ENSMUSG00000115428 Gm41290 2830 ENSMUSG00000115604.1 ENSMUSG00000115604 Gm7691 2831 ENSMUSG00000115611.1 ENSMUSG00000115611 Gm4606 2832 ENSMUSG00000115630.1 ENSMUSG00000115630 Rpl19-ps5 2833 ENSMUSG00000115680.1 ENSMUSG00000115680 Gm35167 2834 ENSMUSG00000115681.1 ENSMUSG00000115681 Gm2682 2835 ENSMUSG00000115801.1 ENSMUSG00000115801 AC160336.1 2836 ENSMUSG00000115855.1 ENSMUSG00000115855 Gm34643 2837 ENSMUSG00000116039.1 ENSMUSG00000116039 Gm49483 2838 ENSMUSG00000116041.1 ENSMUSG00000116041 Gm20369 2839 ENSMUSG00000116212.1 ENSMUSG00000116212 Gm18979 2840 ENSMUSG00000116238.1 ENSMUSG00000116238 Gm49413 2841 ENSMUSG00000116376.1 ENSMUSG00000116376 Tmem249 2842 ENSMUSG00000116389.1 ENSMUSG00000116389 Gm49504 2843 ENSMUSG00000116433.1 ENSMUSG00000116433 Gm49553 2844 ENSMUSG00000116438.1 ENSMUSG00000116438 Gm18911 2845 ENSMUSG00000116504.1 ENSMUSG00000116504 I730030J21Rik 2846 ENSMUSG00000116560.1 ENSMUSG00000116560 AC183095.1 2847 ENSMUSG00000116589.1 ENSMUSG00000116589 CT030190.1 2848 ENSMUSG00000116628.1 ENSMUSG00000116628 AC098883.2 2849 ENSMUSG00000116637.1 ENSMUSG00000116637 AC154540.2 2850 ENSMUSG00000116640.1 ENSMUSG00000116640 AC166114.1 2851 ENSMUSG00000116789.1 ENSMUSG00000116789 CT025521.2 2852 ENSMUSG00000116812.1 ENSMUSG00000116812 AC183097.2 2853 ENSMUSG00000116838.1 ENSMUSG00000116838 AC165953.1 2854 ENSMUSG00000116879.1 ENSMUSG00000116879 AC125141.3

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

2855 ENSMUSG00000116891.1 ENSMUSG00000116891 CT025592.1 2856 ENSMUSG00000116926.1 ENSMUSG00000116926 AC154381.1 2857 ENSMUSG00000116957.1 ENSMUSG00000116957 AC140186.1 2858 ENSMUSG00000117007.1 ENSMUSG00000117007 AC167363.1 2859 ENSMUSG00000117074.1 ENSMUSG00000117074 AC121299.1 2860 ENSMUSG00000117102.1 ENSMUSG00000117102 AC107792.3 2861 ENSMUSG00000117145.1 ENSMUSG00000117145 AC170998.1 2862 ENSMUSG00000117262.1 ENSMUSG00000117262 CT010445.2 2863 ENSMUSG00000117285.1 ENSMUSG00000117285 AC151284.2 2864 ENSMUSG00000117298.1 ENSMUSG00000117298 CT009580.2 2865 ENSMUSG00000117300.1 ENSMUSG00000117300 AC154457.3 2866 ENSMUSG00000117314.1 ENSMUSG00000117314 AC132106.1 2867 ENSMUSG00000117315.1 ENSMUSG00000117315 AC154218.2 2868 ENSMUSG00000117318.1 ENSMUSG00000117318 AC241601.2 2869 ENSMUSG00000117327.1 ENSMUSG00000117327 AC114990.3

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

Bone Marrow-Derived LSK cells from Gene.type /scaffold.name Gene.start.(bp) protein_coding 6 127125162 protein_coding 13 45507444 protein_coding 11 88924020 protein_coding 10 77530252 protein_coding 2 121357714 protein_coding 14 56402581 protein_coding 6 18366478 protein_coding 15 79995874 protein_coding 15 101174067 protein_coding 3 105959369 protein_coding 11 55098115 protein_coding 11 50850685 protein_coding 6 82725025 protein_coding 8 123062942 protein_coding 8 123140192 protein_coding 8 12614277 protein_coding 11 52252371 protein_coding 1 161780689 protein_coding 7 59974149 protein_coding 14 54369442 protein_coding 11 83709015 protein_coding 11 106377656 protein_coding 11 61517249 protein_coding 11 51619735 protein_coding 10 78269178 protein_coding 8 8617434 protein_coding 9 22126727 protein_coding 11 97098071 protein_coding 5 4081145 protein_coding 13 75706757 protein_coding 5 87925579 protein_coding 8 109947914 protein_coding 17 75005568 protein_coding 11 106008124 protein_coding 7 16781340 protein_coding 9 37603290 protein_coding X 73793359 protein_coding 9 44969572 protein_coding 2 91035620 protein_coding 7 24399619 protein_coding 3 104781056 protein_coding 14 55618037 protein_coding 8 70184340 protein_coding 18 10617796 protein_coding 7 25757273 protein_coding 17 46711463 protein_coding 16 38558698 protein_coding 8 83723251 protein_coding 12 31265234

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 5 17781690 protein_coding 7 19696109 protein_coding 1 135253575 protein_coding 6 122819914 protein_coding 19 60889749 protein_coding 7 45729983 protein_coding 7 45699843 protein_coding 15 98724366 protein_coding 7 27532000 protein_coding 7 24897381 protein_coding 2 13651021 protein_coding 7 28293553 protein_coding 17 35681567 protein_coding 3 19957054 protein_coding 8 84872111 protein_coding 11 90336536 protein_coding 13 91460283 protein_coding 1 154390731 protein_coding 15 76659858 protein_coding 7 17031507 protein_coding 6 56069804 protein_coding 16 22857845 protein_coding 1 131638306 protein_coding 9 57790353 protein_coding 17 57358691 protein_coding 5 135887919 protein_coding 8 84249906 protein_coding 15 66929318 protein_coding 11 69420809 protein_coding 15 10177238 protein_coding 15 8634124 protein_coding 6 106710357 protein_coding 13 13437551 protein_coding 8 75093621 protein_coding 7 110868266 protein_coding 3 95124476 protein_coding 3 87796951 protein_coding 7 110768206 protein_coding X 42502453 protein_coding 11 73199460 protein_coding 11 73234292 protein_coding 5 136054492 protein_coding 7 4460674 protein_coding 7 130936111 protein_coding 14 50906478 protein_coding 10 75589340 protein_coding 12 113146316 protein_coding 15 79030874 protein_coding 19 47178820 protein_coding 2 25228898 protein_coding 2 71873224

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 8 21992785 processed_transcript 5 30950066 protein_coding 7 30434982 protein_coding 13 24751845 protein_coding 13 21945094 protein_coding 2 166073089 protein_coding 11 100347327 protein_coding 17 35028605 protein_coding 17 35059035 protein_coding 18 68337603 protein_coding 8 70493158 protein_coding 2 143063039 protein_coding 16 8658580 protein_coding 7 45617289 protein_coding 4 82290173 protein_coding 3 88542029 protein_coding 17 33951999 protein_coding 8 22577075 protein_coding 15 79360684 protein_coding 10 75893413 protein_coding 6 83057844 protein_coding 6 17463800 protein_coding 1 135434580 protein_coding 15 79891659 protein_coding 11 116765025 protein_coding 15 100575318 protein_coding 11 114765388 protein_coding 19 8706882 protein_coding 11 61126755 protein_coding 2 181763332 protein_coding 9 119071527 protein_coding 15 79516411 antisense 17 26554254 protein_coding 12 112620045 protein_coding 7 19463331 protein_coding 5 107744795 protein_coding 13 17695192 protein_coding 8 111311797 protein_coding 10 60302748 protein_coding 9 14541966 protein_coding 8 105703651 protein_coding 9 71215789 protein_coding 11 58379043 protein_coding 1 172196728 protein_coding 7 30291728 protein_coding 6 129831154 protein_coding 7 19852097 protein_coding 8 105276140 protein_coding 12 44205559 protein_coding 2 70661576 protein_coding 8 122578242

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 4 96568429 protein_coding 1 171917515 protein_coding X 9435252 protein_coding 15 89075124 protein_coding 14 56258838 processed_transcript 17 34809092 protein_coding 17 46442448 protein_coding 3 95676201 protein_coding 3 87357881 protein_coding 5 45529705 protein_coding 3 96282909 protein_coding 14 30039939 protein_coding 7 139103638 protein_coding 1 193221634 protein_coding 1 192891233 protein_coding X 36328353 protein_coding 2 181147653 protein_coding 2 180986535 protein_coding 1 194938819 protein_coding 5 146948657 protein_coding 13 24327404 protein_coding 15 83604999 protein_coding 2 164389393 protein_coding 2 164403141 protein_coding 2 164424247 protein_coding X 36112110 protein_coding 11 101170523 protein_coding 11 76120987 protein_coding 11 98036623 protein_coding 11 118428203 protein_coding 11 99065678 protein_coding 11 79591212 protein_coding 11 117825924 protein_coding 2 164839518 protein_coding 8 105943590 protein_coding 5 143622447 protein_coding 13 23684199 protein_coding 11 98464902 protein_coding 11 53457205 protein_coding 11 87592162 protein_coding 11 86768846 protein_coding 2 165405028 protein_coding 11 69326258 protein_coding 11 69964779 protein_coding 12 117877982 protein_coding 11 69765912 protein_coding 11 110269369 protein_coding 11 115268024 protein_coding 11 54100095 protein_coding 11 70344152 protein_coding 11 83511736

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 4 147909753 protein_coding 9 21907491 protein_coding 11 101009452 protein_coding 11 98446394 protein_coding 11 69846376 protein_coding 7 45082913 protein_coding 10 79927043 protein_coding 18 47235598 protein_coding 9 110656503 protein_coding 10 13060504 processed_pseudogene 4 51253025 protein_coding 10 38965515 protein_coding 10 43950636 protein_coding 10 67009189 protein_coding 10 89574020 protein_coding 10 69151434 protein_coding 10 68430953 protein_coding 10 24915221 protein_coding 10 20347770 protein_coding 10 20148471 protein_coding 10 19853900 protein_coding 10 93488768 protein_coding 10 93640681 protein_coding 10 94036001 protein_coding 10 94311949 protein_coding 10 95385362 protein_coding 10 95547007 protein_coding 10 86300372 protein_coding 10 86690209 protein_coding 10 87858265 protein_coding 10 62107655 protein_coding 10 60346851 protein_coding 11 20302180 protein_coding 10 116275523 protein_coding 11 18879817 protein_coding 10 75517551 protein_coding 11 11814101 protein_coding 10 111506286 protein_coding 10 82696160 protein_coding 10 83487450 protein_coding 11 54866383 protein_coding 11 54826866 protein_coding 11 32209585 protein_coding 11 32000463 protein_coding 11 31872211 protein_coding 11 31357307 protein_coding 11 54303798 protein_coding 11 50025346 protein_coding 11 50236461 protein_coding 11 46325150 protein_coding 11 4938754

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 11 46396559 protein_coding 11 4345814 protein_coding 1 134075170 protein_coding 11 6211013 protein_coding 11 3415982 protein_coding 11 5827860 protein_coding 11 5801640 protein_coding 11 5528887 protein_coding 11 5520659 protein_coding 11 58867216 protein_coding 11 61729650 protein_coding 11 90476492 protein_coding 11 89982665 protein_coding 12 13269133 protein_coding 12 8771323 protein_coding 11 109473374 protein_coding 11 109932190 protein_coding 12 28690628 protein_coding 12 26300964 protein_coding 12 25093799 protein_coding 11 105967945 protein_coding 11 80154105 protein_coding 11 106276672 protein_coding 11 72494919 protein_coding 11 72042032 protein_coding 11 116645595 protein_coding 11 71749920 protein_coding 11 116803062 protein_coding 11 70700548 protein_coding 11 94408391 protein_coding 11 97029938 protein_coding 11 70054085 protein_coding 11 69183932 protein_coding 11 69015911 protein_coding 11 68691559 protein_coding 11 68432121 protein_coding 11 67078300 protein_coding 11 100140810 protein_coding 11 102761439 protein_coding 11 102887336 protein_coding 11 103070304 protein_coding 12 65062424 protein_coding 12 91806043 protein_coding 12 75714249 protein_coding 12 76580488 protein_coding 12 76797960 protein_coding 12 72881109 protein_coding 12 73964481 protein_coding 12 80107754 protein_coding 13 8802968 protein_coding 12 99693045

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 12 101645443 protein_coding 12 102394084 protein_coding 12 102554969 protein_coding 13 6579768 protein_coding 12 111292976 protein_coding 12 111961375 protein_coding 12 112146208 protein_coding 12 112850873 protein_coding 13 19623104 protein_coding 13 20794113 protein_coding 13 30749226 protein_coding 13 40859754 protein_coding 13 41309581 protein_coding 13 33027416 protein_coding 13 63285043 protein_coding 13 64161824 protein_coding 13 75869537 protein_coding 13 73604006 protein_coding 13 89655312 protein_coding 13 90935356 protein_coding 13 102693558 protein_coding 13 100407764 protein_coding 13 100108012 protein_coding 13 96648967 protein_coding 13 104228611 protein_coding 13 117602320 protein_coding 14 8431192 protein_coding 13 111746428 protein_coding 13 112464070 protein_coding 13 112598333 protein_coding 14 21733394 protein_coding 14 21750531 protein_coding 14 17660261 protein_coding 14 19811351 protein_coding 14 45283087 protein_coding 14 32028989 processed_pseudogene 12 119260978 protein_coding 14 32322019 protein_coding 14 62292589 protein_coding 14 62392676 protein_coding 14 57806561 protein_coding 14 60634001 protein_coding 14 77904239 protein_coding 14 99046222 protein_coding 14 70217865 protein_coding 14 118937976 protein_coding 14 54541785 protein_coding 14 54722209 protein_coding 14 54614119 protein_coding 14 55784995 protein_coding 14 55941451

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 15 30172593 protein_coding 15 25843180 protein_coding 15 34306677 protein_coding 15 34495304 protein_coding 15 59315077 protein_coding 15 56665627 protein_coding 15 55307750 protein_coding 15 85734983 protein_coding 15 80948490 protein_coding 15 80671847 protein_coding 15 80091334 protein_coding 15 55076099 protein_coding 15 84232043 protein_coding 15 82274893 protein_coding 15 97711015 protein_coding 15 97744770 protein_coding 15 81987835 protein_coding 15 81951108 protein_coding 16 11313812 protein_coding 16 11074911 protein_coding 16 26356642 protein_coding 16 30511855 protein_coding 15 75108158 protein_coding 15 74979534 protein_coding 15 89582533 protein_coding 16 45382135 protein_coding 16 19760208 protein_coding 16 44240180 protein_coding 16 43889800 protein_coding 16 58670292 protein_coding 16 81200697 protein_coding 16 17130138 protein_coding 16 20308387 protein_coding 16 36792884 protein_coding 16 78301489 protein_coding 16 75858793 protein_coding 16 23224740 protein_coding 16 97470965 protein_coding 16 93883901 protein_coding 16 93583457 protein_coding 16 91574503 protein_coding 1 181896384 protein_coding 15 100674421 protein_coding 18 37815079 protein_coding 7 35397035 protein_coding 4 123734559 protein_coding 5 134581366 protein_coding 13 113093825 protein_coding 4 130253495 protein_coding 2 113776362 protein_coding 4 119637704

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 4 33062999 protein_coding 15 88819646 protein_coding 6 124864692 protein_coding 5 137287519 protein_coding 9 106281061 protein_coding 14 55823144 protein_coding 6 124829547 protein_coding 11 3131850 protein_coding 16 32084416 protein_coding 17 7170115 protein_coding 17 12418960 protein_coding 17 12682406 protein_coding 17 14279506 protein_coding 17 23600856 protein_coding 17 23726336 protein_coding 17 40811126 protein_coding 17 47385393 protein_coding 17 47394558 protein_coding 17 49615136 protein_coding 17 31255019 protein_coding 17 31179272 protein_coding 17 71002633 protein_coding 17 71252172 protein_coding 17 71768473 protein_coding 17 73493228 protein_coding 17 73804134 protein_coding 17 73883895 protein_coding 17 64600736 protein_coding 17 90033631 protein_coding 17 25374285 protein_coding 17 23836785 protein_coding 17 24351950 protein_coding 17 86753907 protein_coding 17 87672330 protein_coding 17 24804382 protein_coding 17 55445382 protein_coding 17 26091734 protein_coding 17 26505590 protein_coding 17 27143969 protein_coding 17 83501919 protein_coding 18 16588877 protein_coding 17 34028267 protein_coding 18 35964830 protein_coding 18 35647266 protein_coding 17 34862604 protein_coding 18 32377217 protein_coding 18 38418975 protein_coding 17 35897595 protein_coding 17 36322858 protein_coding 18 37972624 protein_coding 18 46741876

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 18 46850039 protein_coding 18 66458604 protein_coding 18 67289253 protein_coding 18 67488209 protein_coding 18 67933257 protein_coding 18 78750380 protein_coding 18 57878678 protein_coding 18 58008623 protein_coding 18 61045150 protein_coding 18 61105572 protein_coding 19 11321039 protein_coding 19 11586604 protein_coding 19 18670780 protein_coding 19 20783458 protein_coding 19 6084983 protein_coding 19 36348309 protein_coding 19 6046576 protein_coding 19 5364641 protein_coding 19 4099998 protein_coding 19 23758876 protein_coding 19 4930651 protein_coding 19 5473973 protein_coding 19 5465240 protein_coding 19 27216484 protein_coding 19 37697808 protein_coding 19 41029275 protein_coding 19 41600257 protein_coding 19 46573365 protein_coding 8 39581685 protein_coding 19 47646344 protein_coding 19 56912361 protein_coding 19 57452906 protein_coding 19 58795751 protein_coding 11 120610087 protein_coding 11 120635712 protein_coding 11 121036747 protein_coding 19 42755105 protein_coding 19 44293676 protein_coding 19 45363734 protein_coding 19 45552275 protein_coding 19 46341121 protein_coding X 155323918 protein_coding 4 140812983 protein_coding 10 128933818 protein_coding 10 128882295 protein_coding 10 128790910 protein_coding 10 128720134 protein_coding 11 120007313 protein_coding 18 77456110 protein_coding 7 140218267 protein_coding 7 140863666

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 7 141269083 protein_coding 7 141338880 protein_coding 7 141475240 protein_coding 7 141493136 protein_coding 14 121035200 protein_coding X 113297510 protein_coding X 157821436 protein_coding 6 116338024 protein_coding 4 130792537 protein_coding 5 30058202 protein_coding 7 74275419 protein_coding 8 128358604 protein_coding 6 47796141 protein_coding 13 54949411 protein_coding 1 14168954 transcribed_unprocessed_pseudogene 1 21285246 protein_coding 1 16665207 protein_coding 1 65186683 protein_coding 1 63445891 protein_coding 1 62703285 protein_coding 1 45908068 protein_coding 1 67000517 protein_coding 1 66830839 protein_coding 1 60716800 protein_coding 1 60482292 protein_coding 1 59162926 protein_coding 1 40465552 protein_coding 1 40225080 protein_coding 1 37611677 protein_coding 1 37299865 protein_coding 1 24011093 protein_coding 1 74791516 protein_coding 1 74409376 protein_coding 1 71585520 protein_coding 1 75375297 protein_coding 1 85894281 protein_coding 1 92950865 protein_coding 1 90915085 protein_coding 1 91351016 protein_coding 1 144752683 protein_coding 1 140084708 protein_coding 1 139501702 protein_coding 1 120113280 protein_coding 1 138482875 protein_coding 1 136842571 protein_coding 1 130800902 protein_coding 1 135779434 protein_coding 1 135720061 protein_coding 1 134111242 protein_coding 1 134405559 protein_coding 1 134296783

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 1 134289989 protein_coding 1 153218922 protein_coding 1 151571186 protein_coding 1 176814660 protein_coding 1 174172776 protein_coding 1 173962568 protein_coding 1 173896345 protein_coding 1 172475358 protein_coding 1 164931644 protein_coding 1 164437109 protein_coding 1 164151838 protein_coding 1 164115264 protein_coding 1 164048234 protein_coding 1 163245119 protein_coding 1 156424525 protein_coding 1 156310727 protein_coding 1 184896789 protein_coding 1 191325912 protein_coding 2 3284212 protein_coding 1 171113918 protein_coding 1 170704674 protein_coding 1 169949535 protein_coding 2 14229392 protein_coding 2 49619298 protein_coding 2 49787688 protein_coding 2 12106632 protein_coding 2 23506220 protein_coding 2 28192992 protein_coding 2 27886425 protein_coding 2 58567298 protein_coding 2 30400471 protein_coding 2 34941750 protein_coding 2 35313986 protein_coding 2 26580014 protein_coding 2 26055535 protein_coding 2 51948487 protein_coding 2 60750193 protein_coding 2 80500512 protein_coding 2 71271063 protein_coding 2 78868124 protein_coding 2 68861441 protein_coding 2 84988215 protein_coding 2 84980461 protein_coding 2 112261926 protein_coding 2 104721784 protein_coding 2 124089969 protein_coding 2 125247190 protein_coding 2 126034658 protein_coding 2 122426477 protein_coding 2 92599707 protein_coding 2 122234749

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 2 91982328 protein_coding 2 122120108 protein_coding 2 122028546 protein_coding 2 121289600 protein_coding 2 119751320 protein_coding 2 119351229 protein_coding 2 119218119 protein_coding 2 131069220 protein_coding 2 119112793 protein_coding 2 118814003 protein_coding 2 118861954 protein_coding 2 131491496 protein_coding 2 117279993 protein_coding 2 126552407 protein_coding 2 126627442 protein_coding 2 127526473 protein_coding 2 160880670 protein_coding 2 144556229 protein_coding 2 144599897 protein_coding 2 148693985 protein_coding 2 150905400 protein_coding 2 151590549 protein_coding 2 153008890 protein_coding 2 153649450 protein_coding 2 154335380 protein_coding 2 172472520 protein_coding 2 173206612 protein_coding 2 174760619 protein_coding 2 178118975 protein_coding 2 168634438 protein_coding 3 14766216 protein_coding 2 181205562 protein_coding 2 155059310 protein_coding 2 155490379 protein_coding 2 155517948 protein_coding 2 155563181 protein_coding 3 32334792 protein_coding 3 35892105 protein_coding 3 36552606 protein_coding 3 54361109 protein_coding 3 68690644 protein_coding 3 68064802 protein_coding 3 55625195 protein_coding 3 58519817 protein_coding 3 103859795 protein_coding 3 101275899 protein_coding 3 89864059 protein_coding 3 116109949 protein_coding 3 127536714 protein_coding 3 131288441 protein_coding 3 83836272

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 3 81036416 protein_coding 3 127670310 protein_coding 3 89333390 protein_coding 3 89377644 protein_coding 3 88435959 protein_coding 3 88394143 protein_coding 3 87846755 protein_coding 3 86786151 protein_coding 3 86137940 protein_coding 3 84815268 protein_coding 3 122294136 protein_coding 3 121201761 protein_coding 4 11156431 protein_coding 4 12153409 protein_coding 4 17852893 protein_coding 4 21931329 protein_coding 4 21757382 protein_coding 3 142560026 protein_coding 3 142239590 protein_coding 4 33031416 protein_coding 4 32983037 protein_coding 4 28813131 protein_coding 4 45848664 protein_coding 4 48585174 protein_coding 4 63831308 protein_coding 4 59189257 protein_coding 4 62480053 protein_coding 4 62509169 protein_coding 4 53440413 protein_coding 4 53826045 protein_coding 4 43058953 protein_coding 4 43514711 protein_coding 4 44034075 protein_coding 4 102741297 protein_coding 4 99765402 protein_coding 4 109660876 protein_coding 4 107134155 protein_coding 4 119733784 protein_coding 4 119175457 protein_coding 4 123712710 protein_coding 4 123127115 protein_coding 4 136647539 protein_coding 4 117271463 protein_coding 4 116708509 protein_coding 4 116685544 protein_coding 4 115839198 protein_coding 4 137468769 protein_coding 4 137741733 protein_coding 5 17962549 protein_coding 4 129984870 protein_coding 4 129619274

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 4 135494790 protein_coding 4 134468320 protein_coding 4 134356372 protein_coding 4 133212131 protein_coding 4 132974095 protein_coding 4 132732966 protein_coding 4 131768457 protein_coding 4 131843470 protein_coding 4 140906344 protein_coding 5 24862744 protein_coding 4 150897133 protein_coding 4 150914562 protein_coding 4 150853919 protein_coding 4 149125034 protein_coding 5 24393663 protein_coding 4 148602554 protein_coding 4 148495183 protein_coding 5 23787711 protein_coding 4 148152800 protein_coding 4 148098437 protein_coding 4 148077061 protein_coding 4 148004259 protein_coding 4 147860778 protein_coding 4 155384980 protein_coding 5 43868553 protein_coding 5 48327952 protein_coding 5 36017180 protein_coding 5 35757880 protein_coding 5 35652023 protein_coding 5 36806921 protein_coding 5 36868513 protein_coding 5 37289098 protein_coding 5 30814641 protein_coding 5 51454250 protein_coding 5 30711564 protein_coding 5 36473670 protein_coding 5 71569749 protein_coding 5 66676091 protein_coding 5 84054761 protein_coding 5 86071746 protein_coding 5 105876565 protein_coding 5 105077630 protein_coding 5 100845713 protein_coding 5 112255815 protein_coding 5 90518932 protein_coding 5 90891241 protein_coding 5 92006074 protein_coding 5 92137938 protein_coding 5 122550204 protein_coding 5 110339812 protein_coding 6 17065149

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 6 14901349 protein_coding 5 140607320 protein_coding 6 11907809 protein_coding 6 11900292 processed_pseudogene 6 112605544 protein_coding 6 8509600 protein_coding 5 147878437 protein_coding 5 149614287 protein_coding 5 149528679 protein_coding 6 4504814 protein_coding 6 25743737 protein_coding 5 137350109 protein_coding 5 137569840 protein_coding 5 137605103 protein_coding 6 7675169 protein_coding 6 5220852 protein_coding 6 48448229 protein_coding 6 57581000 protein_coding 6 49036546 protein_coding 6 39334773 protein_coding 6 87042846 protein_coding 6 87009236 protein_coding 6 87383256 protein_coding 6 103510586 protein_coding 6 88503579 protein_coding 6 89316314 protein_coding 6 89383146 protein_coding 6 90486427 protein_coding 6 108660629 protein_coding 6 108828641 protein_coding 6 118011438 protein_coding 6 129610323 protein_coding 6 129045901 protein_coding 6 129591782 protein_coding 6 129666015 protein_coding 6 119432531 protein_coding 6 129898996 transcribed_unprocessed_pseudogene 6 130290878 protein_coding 6 131284388 protein_coding 6 142564837 protein_coding 6 142587862 protein_coding 6 145858243 protein_coding 6 145746748 protein_coding 6 144993835 protein_coding 6 142821545 protein_coding 6 146108299 protein_coding 6 113743831 protein_coding 6 148232430 protein_coding 6 114282635 protein_coding 6 148988071 protein_coding 6 128778485

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 6 124996694 protein_coding 6 125232622 protein_coding 6 128609227 protein_coding 6 128887588 protein_coding 7 19083849 protein_coding 7 38261996 protein_coding 7 3908280 protein_coding 7 48830398 protein_coding 7 35334170 protein_coding 7 49778346 protein_coding 7 64501706 protein_coding 7 80343104 protein_coding 7 80186841 protein_coding 7 67647410 protein_coding 7 79133768 protein_coding 7 90302252 protein_coding 7 82173840 protein_coding 7 92741603 protein_coding 7 101576970 protein_coding 7 114549682 protein_coding 7 114415281 protein_coding 7 101092863 protein_coding 7 100545751 protein_coding 7 44605803 protein_coding 7 125467640 protein_coding 7 128129547 protein_coding 7 45207519 protein_coding 7 127989708 protein_coding 7 45554893 protein_coding 7 45613886 protein_coding 7 127296260 protein_coding 7 144838083 protein_coding X 52053021 protein_coding X 59999464 protein_coding X 60055956 protein_coding X 75572046 protein_coding X 134086421 protein_coding X 134149043 protein_coding X 101079210 protein_coding X 73483602 protein_coding X 73853778 protein_coding X 136993155 protein_coding X 140539528 protein_coding 8 12757014 protein_coding 8 12873806 protein_coding 8 13037308 protein_coding 8 13221663 protein_coding 8 15057653 protein_coding 8 18690263 protein_coding 8 18846277 protein_coding 8 27085583

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 8 27138773 protein_coding 7 29170210 protein_coding 8 11198423 protein_coding 8 11312805 protein_coding 8 54954843 protein_coding 8 22974844 protein_coding 8 24727093 protein_coding 5 47983138 protein_coding 8 25720037 protein_coding 8 33782643 protein_coding 8 40926212 protein_coding 8 40511783 protein_coding 8 45885461 protein_coding 8 91111784 protein_coding 6 70844515 protein_coding 8 102632095 protein_coding 8 85299632 protein_coding 8 85324303 protein_coding 8 82331632 processed_transcript 8 92326033 protein_coding 8 116921730 protein_coding 8 94172664 protein_coding 8 94179082 protein_coding 8 114133557 protein_coding 8 94386438 protein_coding 8 94819804 protein_coding 8 95055103 protein_coding 8 95099828 protein_coding 8 95239045 protein_coding 8 71690756 protein_coding 8 120114152 protein_coding 8 70754679 protein_coding 8 70673248 protein_coding 8 70373558 protein_coding 8 125729963 protein_coding 8 69832491 protein_coding 8 69822429 protein_coding 8 104101625 protein_coding 8 104961718 protein_coding 9 14885814 protein_coding 8 111710474 protein_coding 9 40969691 protein_coding 9 40894849 protein_coding 9 48468512 protein_coding 9 32636221 protein_coding 9 35184551 protein_coding 9 35200175 protein_coding 9 51213708 protein_coding 9 47530173 protein_coding 9 45253837 protein_coding 9 44998740

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 9 44981786 protein_coding 9 44379490 protein_coding 9 44309237 protein_coding 9 44273188 protein_coding 9 21588682 protein_coding 9 21723483 protein_coding 9 70798128 protein_coding 9 70407692 protein_coding 9 72438011 protein_coding 9 22411047 protein_coding 9 61953481 protein_coding 9 58006411 protein_coding 9 79598991 protein_coding 9 58582240 protein_coding 9 58874687 protein_coding 9 77430823 protein_coding 9 66158223 protein_coding 9 96539300 protein_coding 9 88548020 protein_coding 9 114756836 protein_coding 9 118478212 protein_coding 9 98287435 protein_coding 9 110722085 protein_coding 15 59648350 protein_coding 9 112065091 protein_coding 9 102834917 protein_coding 9 103111787 protein_coding 9 104046599 protein_coding 9 104288251 protein_coding 9 104547286 protein_coding 9 105989454 protein_coding 9 106838312 protein_coding 9 108689314 protein_coding 6 12311610 protein_coding 1 152399830 protein_coding 6 134830154 protein_coding 1 151852403 protein_coding 6 5264147 protein_coding 19 25236975 protein_coding 17 47815328 protein_coding 1 15853862 protein_coding 7 101822632 protein_coding 2 101714285 protein_coding 18 65265529 protein_coding 3 125865271 protein_coding 2 101624718 protein_coding 1 78657825 protein_coding 11 28339104 protein_coding 4 120854816 protein_coding 17 55749984 protein_coding 16 75745431

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 2 151542483 protein_coding 1 75474569 protein_coding 6 130178675 protein_coding 6 129639064 protein_coding 14 101729957 protein_coding 11 67455437 protein_coding 13 64189268 protein_coding 3 101855776 protein_coding 6 88724412 protein_coding 6 88545114 protein_coding 16 45535309 protein_coding 8 105269801 protein_coding 17 66666947 protein_coding 4 118208213 protein_coding 17 34670535 protein_coding 9 95399292 protein_coding 16 23520291 protein_coding 3 116918258 protein_coding 3 116739999 protein_coding 5 109554709 protein_coding 1 157458577 protein_coding 5 108660331 protein_coding 3 115887837 protein_coding 16 21794346 protein_coding 6 85865422 protein_coding 6 84008590 protein_coding 17 25366550 protein_coding 17 30624354 protein_coding 3 82837228 protein_coding 18 89197431 protein_coding 1 93512079 protein_coding 5 130073326 protein_coding 12 86880701 protein_coding 11 87662722 protein_coding 6 91515928 protein_coding 11 86058138 protein_coding 1 91179822 protein_coding 8 94532990 protein_coding 17 6106437 protein_coding 8 116981810 protein_coding 12 73099609 protein_coding 11 115799183 protein_coding 4 108637466 protein_coding 12 71831078 protein_coding 11 115347707 processed_transcript 11 3452365 protein_coding 10 83230848 protein_coding 15 74762056 protein_coding 11 102453297 protein_coding 10 82629828 protein_coding 17 24414675

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 9 107681500 protein_coding 5 96373955 protein_coding 11 102430315 protein_coding 14 78558750 protein_coding 11 102248882 protein_coding 6 83671215 protein_coding 14 77036772 protein_coding 8 123117374 protein_coding 10 130322870 protein_coding 9 74952884 protein_coding 10 81328731 protein_coding 9 79815051 protein_coding 4 106561038 protein_coding 11 101665541 protein_coding 7 35119293 protein_coding 5 91517615 protein_coding 11 83525778 protein_coding 6 82041043 protein_coding 12 54178981 protein_coding 4 103038065 protein_coding 11 101162679 protein_coding 19 56787481 protein_coding 14 62555737 protein_coding 11 83002158 protein_coding 5 100679484 protein_coding 19 56722372 protein_coding X 169685199 protein_coding 6 101149609 protein_coding 11 80810175 protein_coding 17 24264259 protein_coding 9 124021972 protein_coding 12 56712634 protein_coding 2 29194541 protein_coding 17 52602709 protein_coding 16 32777419 protein_coding 7 97550331 protein_coding 10 112163621 protein_coding 7 97371606 protein_coding 10 111298679 protein_coding 11 99428403 protein_coding 10 79860475 protein_coding 11 99232761 protein_coding 10 79820989 protein_coding 10 108332121 protein_coding 15 85832306 protein_coding 10 106933517 protein_coding 12 40445952 protein_coding 14 50924968 protein_coding 4 41738493 protein_coding 13 23738808 protein_coding 17 35025959

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 2 26628457 protein_coding 18 14968685 protein_coding 19 7056768 protein_coding 12 41451668 unprocessed_pseudogene 17 34342933 protein_coding 8 69037711 protein_coding 3 59113855 protein_coding 11 51692264 protein_coding 7 34201330 protein_coding X 38196573 protein_coding 5 140872990 protein_coding 18 38838673 protein_coding 2 25423267 protein_coding 2 19909780 protein_coding 7 30899176 protein_coding 5 140321656 protein_coding 2 25332338 protein_coding 7 30640999 protein_coding 19 46329812 protein_coding 17 24155833 protein_coding 4 136895917 protein_coding 4 136889804 protein_coding 4 136880129 protein_coding 4 136206365 protein_coding 10 62185396 protein_coding 3 144822623 protein_coding 1 119415465 protein_coding 11 58640465 protein_coding 4 135541888 protein_coding 10 61297833 protein_coding 5 137596645 protein_coding 5 34194893 protein_coding 3 37348346 protein_coding 2 144470557 protein_coding 15 100691813 protein_coding 4 134561690 protein_coding 15 54745702 protein_coding 10 24637914 protein_coding 15 39198261 protein_coding 5 137134922 protein_coding 5 137061504 protein_coding 1 191575636 protein_coding 8 23636019 protein_coding 9 54544794 protein_coding 1 190947646 protein_coding 14 47240944 protein_coding 14 47153895 protein_coding 4 133553376 protein_coding 12 112808937 protein_coding 4 133518963 protein_coding 3 31902507

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 6 72206177 protein_coding 17 34135182 protein_coding 9 99309963 protein_coding 2 19199302 protein_coding 2 18694032 protein_coding 8 22168160 protein_coding 5 66745827 protein_coding 2 158665398 protein_coding 2 158116402 protein_coding 2 129592835 protein_coding 3 136053363 protein_coding 11 99209047 protein_coding 5 124834418 protein_coding 16 10835059 protein_coding 3 135307700 protein_coding 10 58497948 protein_coding 5 124725085 protein_coding 11 98836785 protein_coding 6 55203383 protein_coding 16 10782240 protein_coding 6 54923949 protein_coding 18 60474193 protein_coding 6 54577604 protein_coding 18 32939041 protein_coding 8 47180048 protein_coding 10 44437177 protein_coding 7 113765998 protein_coding 3 97689824 protein_coding 4 83220300 protein_coding 8 46986887 protein_coding 1 171632403 protein_coding 5 24586741 protein_coding 1 171518122 protein_coding 6 125223933 unprocessed_pseudogene 1 171515233 protein_coding 7 112225856 protein_coding 10 42583822 protein_coding 6 51523901 protein_coding 3 96798763 protein_coding 2 155701677 protein_coding 5 24319589 protein_coding 3 96670131 protein_coding 1 171173262 protein_coding 7 110308013 protein_coding 2 155381059 protein_coding 1 170917576 protein_coding 18 70508680 protein_coding 6 39462378 protein_coding 1 170644532 protein_coding 1 169741477 protein_coding 4 58943628

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 1 182275772 protein_coding 3 95526786 protein_coding 6 37327255 protein_coding 17 28142141 protein_coding 15 44457494 protein_coding 7 44310253 protein_coding 1 180935022 protein_coding 7 80860920 protein_coding 11 74383356 protein_coding 5 30868012 protein_coding 8 10984681 protein_coding 1 179546370 protein_coding 17 44777152 protein_coding 13 38500079 protein_coding 13 38345107 protein_coding 3 152817081 protein_coding 14 21983959 protein_coding 13 36867178 protein_coding 3 151437887 protein_coding 5 53466152 protein_coding 3 123267455 protein_coding 1 186622792 protein_coding 17 35567450 protein_coding 4 70427065 protein_coding 3 27416162 protein_coding 5 38706462 protein_coding 1 72159442 protein_coding 16 5086291 protein_coding 5 36966104 protein_coding 10 34151393 protein_coding 17 27856441 protein_coding 17 35552128 protein_coding 6 61180324 protein_coding 17 43801351 protein_coding 6 29917012 protein_coding 19 37021291 protein_coding 5 44472132 protein_coding 5 43233170 protein_coding 8 18932729 protein_coding 16 91053935 protein_coding 11 119355557 protein_coding 5 21186255 protein_coding 11 119228572 protein_coding 10 7832470 protein_coding 11 119077573 protein_coding 10 128232065 protein_coding 2 118779719 protein_coding 3 156561794 protein_coding 2 118528757 protein_coding X 16709282 protein_coding 2 118111876

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 5 12383385 protein_coding 3 142594847 protein_coding 7 130865756 protein_coding 2 93833467 protein_coding 10 127514967 protein_coding 10 127501686 protein_coding 2 93642384 protein_coding 17 35517100 protein_coding 14 56099881 protein_coding 11 48978889 protein_coding 8 3470862 protein_coding 4 25248600 protein_coding 4 24966407 protein_coding 4 24612554 protein_coding 11 72435526 protein_coding 7 27305136 protein_coding 10 127055011 protein_coding X 167242696 protein_coding 2 91275068 protein_coding 11 106311341 protein_coding 10 3740364 protein_coding 17 46496711 protein_coding 14 27038941 protein_coding 16 95359169 protein_coding 3 106147554 protein_coding 2 90782727 protein_coding X 162411954 protein_coding 4 141016637 protein_coding 3 105452330 protein_coding 17 8236043 protein_coding 11 6427229 protein_coding 11 69820876 protein_coding 4 138775735 protein_coding 4 8690406 protein_coding 6 18170687 protein_coding 7 139579376 protein_coding 11 69599736 protein_coding 12 105603085 protein_coding 4 137664726 protein_coding 19 27388702 protein_coding 9 71504347 protein_coding 9 96119362 protein_coding 9 32116136 protein_coding 5 146832890 protein_coding 17 34238903 protein_coding 1 136268123 transcribed_unprocessed_pseudogene 7 14530652 protein_coding 9 62419492 protein_coding 3 87078593 polymorphic_pseudogene 3 86986551 protein_coding 2 73341506

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 1 20996299 lincRNA 18 62751674 protein_coding 11 110100749 protein_coding 17 6659093 protein_coding 18 77757567 protein_coding 15 5095981 protein_coding 19 11667460 protein_coding 1 20777146 protein_coding 1 135371057 protein_coding 18 65980754 protein_coding 11 109573331 protein_coding 1 42952872 protein_coding 2 71453276 protein_coding 1 135262712 protein_coding 11 5276324 protein_coding 6 117900324 protein_coding 13 93771630 protein_coding 5 113937094 protein_coding 6 116633008 protein_coding 1 33852052 protein_coding 5 113612354 protein_coding 9 106440051 protein_coding 7 118535841 protein_coding 1 131797381 protein_coding 3 90526856 protein_coding 12 84918148 protein_coding 15 80572594 protein_coding 4 127354809 protein_coding 11 61684091 protein_coding 1 134193448 protein_coding 5 21884454 protein_coding 7 127256959 protein_coding X 139210042 protein_coding 6 39136623 protein_coding 11 60536381 protein_coding 12 81721010 protein_coding X 136066564 protein_coding 9 103482947 protein_coding 3 89229057 protein_coding 12 76792333 protein_coding 18 33437019 protein_coding 7 45639977 protein_coding 11 120653788 protein_coding 1 151755371 protein_coding 3 92080271 processed_pseudogene 8 5639580 protein_coding 4 121059237 protein_coding 8 71597648 protein_coding 1 173630917 protein_coding 3 69574158 protein_coding 16 57353093

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 4 118687486 protein_coding 18 43475418 protein_coding 7 37472135 protein_coding 3 98160630 protein_coding 17 29827956 protein_coding 4 138709837 bidirectional_promoter_lncRNA 11 120348678 protein_coding 11 59783897 protein_coding 8 71554238 protein_coding 17 73306464 protein_coding 10 80339110 protein_coding 6 122952515 protein_coding 7 102482031 protein_coding 6 129729041 protein_coding 9 111054486 protein_coding 2 77009902 protein_coding 11 101172997 protein_coding 1 92644218 processed_transcript 13 67729262 protein_coding 6 3457096 protein_coding 3 52268336 protein_coding X 96247203 processed_pseudogene 6 48524554 protein_coding 18 12755314 protein_coding 13 60934155 protein_coding 7 104153013 protein_coding 17 57059105 protein_coding 2 30794769 protein_coding 19 23619742 protein_coding 3 100451628 protein_coding 17 24718116 protein_coding 7 45627488 protein_coding 12 30893326 protein_coding 8 72565188 protein_coding 8 110079746 protein_coding 15 74796874 antisense 9 51278513 protein_coding 13 32842092 processed_pseudogene 11 55118101 protein_coding 7 102476579 protein_coding 10 102512222 protein_coding 13 64133018 protein_coding 11 101155907 protein_coding 9 21242912 protein_coding 18 61493794 protein_coding 6 93675455 processed_pseudogene 19 21938079 protein_coding 17 80290203 protein_coding 4 119169513 protein_coding 13 100759674 protein_coding 11 75193783

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 5 28071363 transcribed_processed_pseudogene 3 96606659 protein_coding 11 69396519 protein_coding 1 174040705 protein_coding 1 128588199 protein_coding 2 86020633 protein_coding 17 87635979 protein_coding 13 4590750 protein_coding 6 59347226 protein_coding 13 76054851 protein_coding 9 114401076 protein_coding 8 40990914 protein_coding 1 84036296 protein_coding 12 16988648 protein_coding 4 146892406 protein_coding 11 115462474 protein_coding 7 142325837 transcribed_processed_pseudogene 17 40115358 protein_coding 7 106156556 lincRNA 7 125284025 protein_coding 12 58264720 protein_coding 7 83631959 protein_coding 7 30751471 protein_coding 8 31187331 protein_coding 18 37504264 protein_coding 3 107211293 protein_coding 8 71406010 protein_coding 18 37484795 protein_coding 9 98422961 protein_coding 7 29221926 protein_coding X 136270253 protein_coding 4 138454314 protein_coding 5 115122550 protein_coding 8 4226827 protein_coding 4 40472180 protein_coding 4 127351086 protein_coding 11 8826708 unprocessed_pseudogene 18 27598644 protein_coding 9 111271929 protein_coding 10 75550123 protein_coding 10 84526305 protein_coding 10 5593775 protein_coding 5 108669878 protein_coding 1 174049205 protein_coding 17 47412734 protein_coding 11 98982180 protein_coding 14 51255262 protein_coding 12 100876682 protein_coding 17 46297421 lincRNA 13 19727426 protein_coding 11 49109982

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 7 131032053 protein_coding 7 28543596 protein_coding 19 36917550 protein_coding 10 121641588 processed_pseudogene 8 73749475 protein_coding 4 148434495 protein_coding 9 60568859 protein_coding 1 93235841 protein_coding 15 83226722 protein_coding 11 113619342 protein_coding 16 46152985 protein_coding 19 40612366 protein_coding 14 54278253 protein_coding 15 97244125 protein_coding 13 95601803 protein_coding 1 118834132 protein_coding 11 115899966 protein_coding 1 74191785 protein_coding 11 115051917 protein_coding 9 45079183 protein_coding 19 37899036 protein_coding X 109196756 protein_coding 8 4257660 protein_coding 9 106429454 protein_coding 11 48904656 protein_coding 6 65671590 protein_coding 6 122921848 protein_coding 9 124101950 protein_coding 4 74013442 protein_coding 7 29697219 protein_coding 9 14748320 protein_coding 9 41964720 protein_coding 7 127050156 protein_coding 9 95752642 protein_coding 11 55049731 protein_coding 1 85938318 protein_coding 17 23833347 protein_coding 13 56173704 protein_coding 2 43748824 protein_coding 13 112288451 protein_coding 8 13952008 protein_coding 9 109812280 protein_coding 3 59096448 protein_coding 10 85959340 protein_coding 19 41062474 protein_coding 19 44333092 protein_coding 2 120166412 protein_coding X 101731535 protein_coding 6 129577905 protein_coding 16 96590840 protein_coding 3 123076519

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 14 121911253 protein_coding 4 129219578 protein_coding 10 19847916 processed_pseudogene 10 85313488 protein_coding 9 66508459 protein_coding 11 97840780 processed_pseudogene 4 18844202 protein_coding 14 32856756 protein_coding 2 30889471 protein_coding 8 124369049 protein_coding 13 99184823 protein_coding X 107088492 lincRNA 3 96269721 protein_coding 4 134537892 protein_coding 10 10335703 protein_coding 7 107567446 protein_coding 7 140173217 protein_coding 13 95954594 protein_coding 2 134786067 protein_coding 9 96470937 protein_coding 7 30818348 protein_coding 1 64785983 protein_coding 10 26229707 protein_coding 15 37366175 protein_coding 7 104148259 protein_coding 18 36725074 protein_coding 16 93605853 protein_coding 5 64952031 protein_coding 4 43496142 protein_coding 17 48264295 protein_coding 1 75479532 protein_coding 14 50357914 protein_coding 1 135953578 protein_coding 1 133679091 protein_coding 12 112760655 protein_coding 5 144190286 protein_coding 7 47185707 protein_coding 1 54645340 protein_coding 7 83932857 lincRNA 2 169020025 protein_coding 13 12269426 protein_coding 6 72513644 protein_coding 6 48589445 protein_coding 6 129647496 protein_coding 1 85717083 protein_coding 5 34660379 protein_coding 7 122288751 protein_coding 9 108479736 protein_coding 4 96516138 protein_coding 8 84956610 protein_coding 13 69702832

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 5 130217081 protein_coding 13 19749682 protein_coding 2 165111507 transcribed_unprocessed_pseudogene 15 75427606 protein_coding 7 27499324 protein_coding 5 113735803 protein_coding 7 3390683 protein_coding 15 79915807 protein_coding 16 90386013 protein_coding 15 66670753 protein_coding 2 52038009 protein_coding 18 56509687 protein_coding 9 109095389 protein_coding 2 121046111 protein_coding 17 36005695 lincRNA 3 100489664 protein_coding 7 28833854 protein_coding 7 30036359 antisense 1 106541943 protein_coding 2 18040676 protein_coding 17 36185572 protein_coding 15 89322720 protein_coding 5 115429599 protein_coding 15 7090614 protein_coding 15 83299739 protein_coding 12 8497661 protein_coding 8 54520433 protein_coding 15 43864646 protein_coding 6 48684549 protein_coding 15 100304140 protein_coding 7 140247284 protein_coding 4 33208991 protein_coding 5 72695978 protein_coding 10 116417861 protein_coding 15 92051165 protein_coding 9 53684110 protein_coding 8 72319033 protein_coding 1 175962306 pseudogene 4 3806635 protein_coding 2 105224320 processed_transcript 7 126768082 processed_pseudogene 7 3109020 protein_coding 11 46810800 protein_coding 7 114046782 processed_pseudogene 13 66007737 protein_coding 7 24333082 antisense 1 191886130 protein_coding 19 11647279 protein_coding 6 72355447 protein_coding 8 88647315 antisense 11 116752167

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 7 35578993 protein_coding 1 183326725 protein_coding 10 49094833 protein_coding 7 104244457 protein_coding 8 84173731 protein_coding 11 93098028 protein_coding 4 126286793 protein_coding 18 80046895 protein_coding 6 34029448 protein_coding 14 32159865 protein_coding 3 106684987 protein_coding 9 99243367 protein_coding 19 11443553 protein_coding 4 146502027 protein_coding 5 25759997 protein_coding 7 13277283 protein_coding 6 72608432 protein_coding 3 84666192 protein_coding 7 43562256 protein_coding 17 37083871 protein_coding 10 111985448 protein_coding 11 58948920 protein_coding 8 126298558 protein_coding 13 12565874 protein_coding 6 85910154 protein_coding 14 52110704 protein_coding 11 70790932 protein_coding 6 41521787 protein_coding 11 116675303 protein_coding 10 60181532 protein_coding 2 112631355 protein_coding 7 104470014 protein_coding 4 154170730 protein_coding 9 122923072 protein_coding 11 5969644 protein_coding 4 62525369 protein_coding 18 15832794 protein_coding 14 113314608 protein_coding 3 108012255 protein_coding 11 48887422 protein_coding 3 37714190 protein_coding 4 154869585 protein_coding 13 67831106 protein_coding 11 58432559 pseudogene 18 10145453 protein_coding 17 45630204 protein_coding 14 36874936 protein_coding 2 25863734 protein_coding 7 45816460 protein_coding 7 126797668 processed_transcript 4 109651529

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 18 48045335 protein_coding 5 77086988 processed_pseudogene 9 78820638 protein_coding 9 42963842 protein_coding 1 174391046 processed_pseudogene 5 43943903 protein_coding 6 122990367 protein_coding 17 35823230 processed_pseudogene 13 108670603 protein_coding 17 35861318 protein_coding 4 62559847 protein_coding 3 41626720 protein_coding 15 73723145 protein_coding 10 61197112 protein_coding 5 144545902 protein_coding 8 106572966 protein_coding 10 68723646 processed_pseudogene 11 54199433 protein_coding 7 140343815 protein_coding 4 54945048 protein_coding 18 36017707 protein_coding 7 34674468 protein_coding 7 104263386 protein_coding 8 95017692 protein_coding 10 9622936 protein_coding 9 123852315 protein_coding 17 35439155 protein_coding 7 140954837 protein_coding 16 33056453 protein_coding 13 22040636 protein_coding 3 89939481 protein_coding X 135718667 protein_coding 3 40531286 protein_coding 11 68901583 protein_coding 9 38752299 protein_coding 14 56059629 protein_coding 16 39984361 protein_coding 19 40928927 protein_coding 4 63362449 protein_coding 8 94923694 protein_coding 11 87033867 processed_pseudogene 18 82523544 protein_coding 6 130013033 processed_pseudogene 2 179177425 protein_coding 17 37279043 protein_coding 3 130726831 protein_coding 7 24431922 protein_coding 7 140941391 protein_coding X 106187100 protein_coding 16 44811733 transcribed_processed_pseudogene 14 89896228

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 14 51853699 protein_coding 1 88499871 protein_coding 1 107511423 processed_pseudogene 5 3236431 protein_coding 3 10204088 protein_coding 4 147673502 protein_coding 7 4337724 protein_coding 4 135895394 processed_pseudogene 14 88123017 protein_coding 3 106113229 protein_coding 17 28066745 protein_coding 6 21985916 protein_coding 8 31814551 protein_coding 6 8630527 protein_coding 4 149176319 antisense 11 89064729 transcribed_processed_pseudogene 6 148354656 protein_coding 17 27422387 protein_coding 15 94629232 protein_coding 10 82619851 protein_coding 15 76612383 pseudogene 18 60441753 protein_coding 5 113490333 protein_coding 7 25680780 protein_coding 5 107830099 protein_coding 15 74876987 protein_coding 13 46273721 protein_coding 17 37262711 processed_pseudogene 8 102864845 protein_coding 19 60837277 protein_coding 7 34912379 protein_coding 7 45621811 processed_pseudogene 2 80837141 protein_coding 6 48647234 protein_coding 6 105677660 protein_coding 12 112644679 Mt_rRNA MT 70 Mt_tRNA MT 5192 snoRNA 12 17546146 snoRNA 11 106500993 miRNA 8 84208672 miRNA 8 84208518 protein_coding 16 13981699 protein_coding 4 146097298 lincRNA 4 119054790 protein_coding 4 92190744 protein_coding 4 62383654 protein_coding 4 41723836 protein_coding 7 104299894 protein_coding 12 104214544 protein_coding 7 41395945

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

processed_pseudogene 12 24638669 protein_coding 5 109996521 protein_coding 5 144194442 protein_coding 1 174365122 protein_coding 1 173673675 protein_coding 9 48654297 protein_coding 7 17074040 protein_coding 5 114289166 pseudogene 1 105455971 processed_pseudogene 5 105797321 protein_coding 5 88519809 unprocessed_pseudogene 17 33974831 protein_coding 5 73606642 protein_coding 5 72603696 protein_coding 17 35470089 protein_coding 5 42067960 protein_coding 6 145615757 protein_coding 6 130218605 protein_coding 19 9283238 protein_coding 6 129697218 protein_coding 4 147132038 protein_coding 15 82233779 protein_coding 15 82221743 protein_coding X 8366978 protein_coding 15 78479256 protein_coding 15 77422209 protein_coding 6 40542171 protein_coding 6 87730869 transcribed_unprocessed_pseudogene 6 85152621 protein_coding 6 83219828 protein_coding 14 51056698 processed_pseudogene 8 13896311 protein_coding 16 10545339 protein_coding 6 29433256 protein_coding 3 108556425 protein_coding 3 108383839 protein_coding 3 95236920 protein_coding 3 94933056 protein_coding 3 94693556 protein_coding 3 40708855 protein_coding 13 67424549 protein_coding 13 30659999 protein_coding 13 23744973 transcribed_processed_pseudogene 10 88729541 protein_coding 11 115042131 protein_coding 17 21816885 protein_coding 11 90030348 protein_coding 13 62864753 protein_coding 19 8989284 protein_coding 8 122619471 protein_coding 11 32296489

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 8 105252638 processed_pseudogene 8 89186946 lincRNA 15 68792320 protein_coding 8 35587798 protein_coding 9 108049242 protein_coding 9 78395777 protein_coding 9 45117782 protein_coding 9 45055186 protein_coding 7 128154376 protein_coding 3 104822779 protein_coding 11 71153102 protein_coding 11 69838514 protein_coding 11 63885792 protein_coding 7 102096879 protein_coding 1 173519717 protein_coding 1 172596642 protein_coding 7 73375509 protein_coding 7 45684022 protein_coding 4 146449023 protein_coding 4 131921771 protein_coding 1 91145089 protein_coding 5 66016549 protein_coding 7 16944682 protein_coding 4 120666572 protein_coding 7 4237754 protein_coding 17 75435905 protein_coding 6 129766568 protein_coding 13 100211739 protein_coding 12 84677277 protein_coding 10 18128903 protein_coding 14 50789248 protein_coding 14 32659119 protein_coding 13 4228700 protein_coding 16 43648867 protein_coding 16 36359382 processed_pseudogene 6 18824552 processed_pseudogene 19 9557792 protein_coding 15 78325752 protein_coding 15 78282507 protein_coding 15 57694665 transcribed_unprocessed_pseudogene 8 20262613 protein_coding 18 62922327 protein_coding 14 51091150 protein_coding 7 104218793 processed_pseudogene 1 51940664 protein_coding 14 54872669 protein_coding 14 44102654 unprocessed_pseudogene 14 44046985 protein_coding 5 125389322 lincRNA 15 36870501 protein_coding 6 118461950

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

lincRNA 6 143245888 unprocessed_pseudogene 6 130082897 protein_coding 6 130269194 protein_coding 5 104813169 protein_coding 5 72513301 processed_transcript 11 59505662 pseudogene 11 59208246 protein_coding X 107255878 IG_V_gene 6 69243158 antisense 11 11695133 protein_coding 17 82539258 protein_coding 17 36164443 transcribed_unprocessed_pseudogene 17 36141758 unprocessed_pseudogene 17 36109234 polymorphic_pseudogene 17 36080115 protein_coding 17 36042961 protein_coding 1 173747293 protein_coding 1 173723427 protein_coding 1 170232749 processed_transcript 18 77793259 processed_transcript 1 153404827 protein_coding 1 79702262 protein_coding 1 54472994 processed_pseudogene 4 146475332 antisense 4 142083972 lincRNA 7 113700890 protein_coding 4 41699989 unprocessed_pseudogene 7 106596743 protein_coding 7 103934347 protein_coding 7 46740497 protein_coding 7 45413695 protein_coding 7 45125558 protein_coding 7 42609526 protein_coding 8 85108553 protein_coding 3 144910921 TEC 8 70931405 protein_coding 7 25461707 protein_coding 7 24610763 processed_pseudogene 9 57483963 protein_coding 3 105973711 protein_coding 7 18890883 protein_coding 7 3884242 transcribed_unprocessed_pseudogene 7 3860681 protein_coding 3 90537254 protein_coding 9 21755442 processed_pseudogene 3 88576410 protein_coding 9 15910189 protein_coding 2 168260117 processed_transcript 2 167062934 protein_coding 3 51660360 protein_coding 2 152962485

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 2 152507798 protein_coding 2 150470991 protein_coding 2 150254518 protein_coding 2 148404466 protein_coding 13 62479827 processed_transcript 2 120041493 antisense 16 32665223 protein_coding 16 32179823 protein_coding 19 4164324 protein_coding 2 69670120 protein_coding 2 54084093 processed_pseudogene 2 35340409 protein_coding 11 116653534 protein_coding 11 115912017 protein_coding 15 74994877 protein_coding 7 66079649 miRNA 6 47803576 protein_coding 2 84669215 TR_V_gene 6 41135145 TR_J_gene 6 41533864 TR_J_gene 6 41534001 TR_J_gene 6 41534323 TR_J_gene 6 41534811 TR_J_gene 6 41535084 TR_J_gene 6 41535554 TR_J_gene 6 41535642 TR_J_gene 6 41543453 TR_C_gene 6 41546730 TR_V_gene 6 41557691 IG_LV_gene 6 43081518 IG_V_gene 6 67555497 IG_V_gene 6 67766036 IG_V_gene 6 67861153 IG_V_gene 6 67954228 IG_V_gene 6 68036812 IG_V_gene 6 68219981 IG_V_gene 6 68425575 IG_V_gene 6 68437440 IG_V_gene 6 68570763 IG_V_gene 6 68768555 IG_V_gene 6 68834846 IG_V_gene 6 68862265 IG_V_gene 6 68910411 IG_V_gene 6 68939602 IG_V_gene 6 68990758 IG_V_gene 6 69016558 IG_V_gene 6 69042972 IG_V_gene 6 69184826 IG_V_gene 6 69226854 IG_V_gene 6 69267888 IG_V_gene 6 69304834

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

IG_V_gene 6 69377944 IG_V_gene 6 69416893 IG_V_gene 6 69544359 IG_V_gene 6 69575975 IG_V_gene 6 69700767 IG_V_gene 6 69726573 IG_V_gene 6 69764523 IG_V_gene 6 69963312 IG_V_gene 6 69992465 IG_V_gene 6 70010949 IG_V_gene 6 70074024 IG_V_gene 6 70117061 IG_V_gene 6 70171809 IG_V_gene 6 70193228 IG_V_gene 6 70216858 IG_V_gene 6 70314895 IG_V_gene 6 70355852 IG_V_gene 6 70457501 IG_V_gene 6 70572633 IG_V_gene 6 70607437 IG_J_gene 6 70722562 IG_J_gene 6 70722916 IG_J_gene 6 70723223 IG_J_gene 6 70723548 IG_J_gene 6 70723886 IG_C_gene 6 70726435 IG_C_gene 12 113356224 IG_C_gene 12 113418558 IG_J_gene 12 113428514 IG_J_gene 12 113429085 IG_J_gene 12 113429468 IG_J_gene 12 113429781 IG_D_gene 12 113482170 IG_V_gene 12 113578504 IG_V_gene 12 113796138 IG_V_gene 12 114153180 IG_V_gene 12 113912025 IG_V_gene 12 113948282 IG_V_gene 12 113896408 IG_V_gene 12 114176438 IG_V_gene 12 114222788 IG_V_gene 12 114357759 IG_V_gene 12 114288152 IG_V_gene 12 114322327 IG_V_gene 12 114366521 IG_V_gene 12 114434788 IG_V_gene 12 114564578 IG_V_gene 12 114682632 IG_V_gene 12 114991108 IG_V_gene 12 115647945 TR_V_gene 13 19184974

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

TR_C_gene 13 19304649 TR_V_gene 13 19336573 TR_V_gene 13 19339989 TR_V_gene 14 53634829 TR_J_gene 14 54123138 TR_J_gene 14 54136779 TR_C_gene 14 54220521 IG_V_gene 16 19085017 IG_C_gene 16 19198396 IG_V_gene 16 19241207 IG_V_gene 16 19260401 miRNA 7 75757259 snRNA 5 38699706 antisense X 96239926 protein_coding 13 21495223 protein_coding 4 147540218 protein_coding 3 154663859 processed_pseudogene 5 8971948 protein_coding 1 175977777 antisense 17 12741311 protein_coding 11 120762794 processed_pseudogene 4 88599175 protein_coding 4 155409190 protein_coding 4 147753974 protein_coding 4 145510759 lincRNA 4 138215714 protein_coding 4 134510999 protein_coding 4 129491190 unprocessed_pseudogene 11 116739062 protein_coding 7 105895139 protein_coding 7 30653711 protein_coding 7 16061814 protein_coding 7 3424195 protein_coding 11 58954685 protein_coding 2 175166255 protein_coding 11 49057194 protein_coding 15 84720052 protein_coding 13 67387905 protein_coding 15 75044018 protein_coding 15 71795795 protein_coding 8 70139711 protein_coding 2 131909928 protein_coding 2 127456498 protein_coding 2 122484941 protein_coding 5 143403838 processed_pseudogene 1 153305432 protein_coding 1 182954788 processed_pseudogene 6 128976866 protein_coding 9 124121543 protein_coding 6 128813706 protein_coding 6 128705836

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 5 105115767 protein_coding 9 88688602 protein_coding 1 78658038 protein_coding X 101849385 protein_coding 17 36055816 protein_coding 17 35320405 protein_coding 17 34153072 protein_coding 1 59120935 protein_coding 17 33875666 protein_coding 1 58278326 protein_coding 9 51270258 processed_pseudogene 6 46529354 sense_intronic 12 84922542 processed_transcript 1 9560832 protein_coding 10 7440362 protein_coding 6 130043731 protein_coding 6 130363917 protein_coding 13 21501029 protein_coding 10 127031004 processed_pseudogene 6 37806086 processed_pseudogene X 141980175 processed_pseudogene 2 143506411 unprocessed_pseudogene 7 3788883 processed_pseudogene X 107279015 processed_pseudogene 2 90804260 processed_pseudogene 8 97427712 processed_pseudogene 11 58097104 unprocessed_pseudogene 3 94720023 processed_pseudogene 2 83353157 processed_pseudogene 1 10695123 processed_pseudogene 2 152353615 processed_pseudogene 4 11144710 protein_coding 17 34211312 processed_pseudogene 4 100567108 processed_pseudogene X 66778442 processed_pseudogene 3 93278141 polymorphic_pseudogene 7 3731630 processed_pseudogene 6 85076192 processed_pseudogene X 52898588 unprocessed_pseudogene 7 4274189 processed_pseudogene X 128261411 processed_pseudogene 7 63542479 processed_pseudogene 16 42955631 processed_pseudogene 4 146480667 processed_pseudogene 4 125504288 unprocessed_pseudogene 6 129795804 protein_coding 2 153696652 transcribed_unprocessed_pseudogene 4 145446740 processed_pseudogene 7 104501055 processed_pseudogene X 49660960 processed_pseudogene 4 46243014

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

transcribed_unprocessed_pseudogene 11 3125904 processed_pseudogene 11 83027500 processed_pseudogene 1 99790429 processed_pseudogene 2 40555752 processed_pseudogene 4 147527719 processed_pseudogene 11 104571268 processed_pseudogene 6 117997207 protein_coding 16 93628097 unprocessed_pseudogene 2 22590024 transcribed_unprocessed_pseudogene 7 126687459 processed_pseudogene 1 21511933 unprocessed_pseudogene 13 100340144 processed_pseudogene 4 80003396 unprocessed_pseudogene 6 129972380 processed_pseudogene 13 24410106 unprocessed_pseudogene 11 49069696 processed_pseudogene 8 19535454 processed_pseudogene 4 80003989 processed_pseudogene 2 40127504 processed_pseudogene 4 12114284 processed_pseudogene 11 90516777 processed_pseudogene 18 12742464 processed_pseudogene X 13218210 processed_pseudogene X 80533745 unprocessed_pseudogene 2 22588103 unprocessed_pseudogene 7 42047948 unprocessed_pseudogene 2 122427194 processed_pseudogene 4 122008193 processed_pseudogene 11 6453151 processed_pseudogene 4 144247777 processed_pseudogene 2 28933610 processed_pseudogene 2 104820179 processed_pseudogene 5 55624190 processed_pseudogene 4 71370738 unprocessed_pseudogene 2 84317339 processed_pseudogene 11 75427753 processed_pseudogene 11 72833461 processed_pseudogene 4 69954166 processed_pseudogene 11 16514533 processed_pseudogene X 13202571 unprocessed_pseudogene 4 145825237 unprocessed_pseudogene 2 121485432 misc_RNA 8 3615529 processed_transcript 4 155398763 antisense 2 129158666 processed_transcript 10 86692119 antisense 8 41017468 antisense 4 53562983 lincRNA 13 23527011 lincRNA 13 23427975 processed_transcript 4 33027142

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

lincRNA 3 156546753 sense_intronic 14 121248706 processed_transcript 1 172538133 lincRNA 4 115818857 processed_transcript 10 105573953 lincRNA 11 75422731 antisense 17 71557027 transcribed_processed_pseudogene 17 28075050 protein_coding 7 19099046 processed_pseudogene 4 69853947 antisense 11 115462045 processed_pseudogene 10 42054113 antisense 8 41053110 processed_transcript 11 18845851 lincRNA 11 58865965 antisense 6 50566643 antisense 6 128951204 antisense 4 137882370 antisense 10 116473163 antisense 11 87795784 processed_transcript 11 59199836 antisense 11 103344753 antisense 11 69682138 processed_transcript 4 140810993 processed_transcript 13 28460034 processed_transcript 7 48877958 antisense 17 31152752 lincRNA 6 145250529 protein_coding 6 54429603 unprocessed_pseudogene 17 35180535 lincRNA 13 111867936 unitary_pseudogene 11 102732405 sense_intronic 5 34211810 antisense 1 178313328 lincRNA 2 48062548 processed_transcript 8 106135400 antisense 11 52276055 antisense 5 24902569 processed_transcript 11 23497753 antisense 11 17953970 antisense 17 45663519 processed_transcript 2 91044092 unprocessed_pseudogene 7 105824223 processed_transcript 17 29890084 processed_transcript 18 50042730 processed_transcript X 108833800 antisense 2 129182482 antisense X 169985801 lincRNA 4 53261356 antisense 11 120215082 antisense 6 32511073

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

lincRNA 4 11122805 lincRNA 1 60776665 lincRNA 4 135118221 lincRNA 9 79793641 antisense 19 5406740 protein_coding 11 58063552 antisense 2 151947273 processed_pseudogene 1 81741985 antisense 4 41642185 processed_transcript 2 129060946 unprocessed_pseudogene 8 19682449 lincRNA 4 117496452 lincRNA 2 19676711 lincRNA 11 113043895 lincRNA 4 148713703 lincRNA 6 145303152 protein_coding 11 70615848 lincRNA 5 115359078 protein_coding 19 33719670 processed_transcript 6 8488795 processed_transcript 11 58322988 lincRNA 2 84500760 antisense 11 11557421 processed_transcript 8 72147601 antisense 7 128001899 lincRNA 2 157595583 lincRNA 11 88718645 IG_V_gene 12 114455626 lincRNA 18 33794892 processed_transcript 1 146802965 antisense 2 172425804 protein_coding 10 83722865 antisense 1 130422824 miRNA 15 79375228 snoRNA 14 77540642 protein_coding 1 88087813 protein_coding 15 10358532 antisense 19 53819354 processed_pseudogene 1 163729569 lincRNA 9 112227579 protein_coding 6 130115226 processed_pseudogene 6 8377596 protein_coding X 136974022 protein_coding 14 43925390 protein_coding 9 89199209 protein_coding 5 137612503 lincRNA 6 87675593 antisense 7 19920729 transcribed_unprocessed_pseudogene 6 85774393 antisense 8 94379184 protein_coding 8 70508263

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 14 43922720 protein_coding 16 44867097 protein_coding 7 104329471 unprocessed_pseudogene 1 173776529 protein_coding 11 116843278 protein_coding 1 173849126 lincRNA 1 135606447 processed_pseudogene 9 59471759 protein_coding 1 133603871 sense_intronic 5 73210156 protein_coding 10 69209762 protein_coding 6 87104746 processed_transcript 17 33759992 processed_pseudogene 1 16768279 protein_coding 14 5939225 protein_coding 9 105856078 unprocessed_pseudogene 17 36066108 processed_pseudogene 13 51202727 protein_coding 3 96261682 processed_pseudogene 6 136486122 protein_coding 14 7293648 protein_coding 1 177983423 protein_coding 17 18914300 protein_coding 9 109074568 processed_pseudogene 17 78850792 processed_transcript 3 106481982 IG_V_pseudogene 12 113574245 protein_coding 17 18573151 processed_pseudogene 18 90311825 protein_coding 17 35342242 protein_coding 16 5147109 protein_coding 14 6735685 IG_V_pseudogene 6 68161415 processed_pseudogene 9 63443166 protein_coding 1 15287254 protein_coding 18 8694077 protein_coding 14 7083208 antisense 5 114773737 unprocessed_pseudogene 17 34744753 protein_coding 7 19852003 lincRNA 17 34249057 unprocessed_pseudogene 17 35358989 processed_pseudogene 9 21533627 unprocessed_pseudogene 17 36210276 processed_pseudogene 17 35445856 processed_pseudogene 17 36157988 protein_coding 12 34984761 protein_coding 7 42579783 lincRNA 19 5795690 protein_coding 17 33905135 sense_intronic 5 136863637

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 7 42473386 unprocessed_pseudogene 17 35304206 transcribed_unprocessed_pseudogene 17 35278176 unprocessed_pseudogene 17 36201996 antisense 17 33908182 processed_transcript 17 37246961 processed_transcript 2 173022503 protein_coding 3 95129536 sense_overlapping 15 88889780 protein_coding 5 137629121 processed_transcript 11 83291699 sense_intronic 6 99384607 antisense 17 24528248 IG_V_gene 6 68270485 unprocessed_pseudogene 17 6613753 IG_V_gene 12 115158403 IG_V_gene 12 115847881 IG_V_gene 6 67839793 IG_V_gene 12 114851190 protein_coding 14 19563800 IG_V_gene 6 69438218 TR_V_gene 14 53559632 IG_V_gene 12 114196439 IG_V_gene 12 115912344 IG_V_gene 12 115507545 protein_coding 11 94281873 IG_V_gene 6 69775750 IG_V_gene 12 114109001 IG_V_gene 6 70518250 IG_V_gene 12 115802648 protein_coding 7 45241085 IG_V_gene 12 113611187 IG_V_gene 12 113838526 IG_V_gene 12 115119748 processed_pseudogene 8 94405211 IG_V_gene 6 69059690 IG_V_gene 6 69631646 IG_V_gene 12 114299961 IG_V_gene 6 68121046 processed_pseudogene 4 32964888 IG_V_gene 6 70143593 IG_V_gene 6 69823355 protein_coding 15 34349051 IG_V_gene 6 67724902 processed_pseudogene 1 43189156 processed_pseudogene 8 129252998 IG_V_gene 12 113981879 protein_coding 14 6087295 protein_coding 19 61174686 IG_V_gene 12 114937113 processed_pseudogene 7 104949915

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

IG_V_gene 12 114583569 IG_V_gene 6 70406469 TR_V_gene 14 53665929 IG_V_gene 12 115242802 IG_V_gene 6 68049983 protein_coding 12 105453856 IG_V_gene 6 70215400 IG_V_gene 12 115980702 protein_coding 13 62368328 IG_V_gene 12 113625506 IG_V_gene 6 69681406 IG_V_gene 6 69858420 processed_pseudogene 4 147187708 IG_V_gene 12 115952538 IG_V_gene 12 115567149 antisense 12 102612680 IG_V_gene 12 114538495 IG_V_gene 12 115145487 IG_V_gene 12 113661769 IG_V_gene 6 70663275 IG_V_gene 6 70588189 IG_V_gene 6 70698449 unprocessed_pseudogene 8 20567597 IG_V_gene 12 114615850 IG_V_gene 12 113702124 protein_coding 15 101050194 IG_V_gene 12 114487136 IG_V_gene 6 68016718 IG_V_gene 12 115593110 IG_V_gene 12 113769850 IG_V_gene 12 113859149 IG_V_gene 12 113994469 transcribed_processed_pseudogene X 152909505 IG_V_gene 12 113597446 IG_V_gene 6 70260409 IG_V_gene 12 114059845 transcribed_processed_pseudogene 3 12855836 TR_D_gene 6 41533201 IG_V_gene 6 70703578 IG_V_gene 12 114523441 IG_V_gene 6 67913573 IG_V_gene 6 69648824 IG_V_gene 12 114723772 IG_V_gene 6 68256389 IG_V_gene 6 70371439 IG_V_gene 12 114945950 IG_V_gene 12 113653291 IG_V_gene 12 114896238 protein_coding 13 119710094 IG_V_gene 12 114479005 IG_V_gene 12 115833950

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

IG_V_gene 12 115757984 IG_V_gene 12 115446409 IG_V_gene 12 116000028 processed_pseudogene 15 45978360 TR_D_gene 14 54122226 processed_pseudogene 4 145837219 protein_coding 17 6430112 IG_V_gene 12 115868773 IG_V_gene 6 67609713 processed_pseudogene 6 7982541 IG_V_gene 12 114416596 IG_V_gene 12 114708648 processed_pseudogene 13 85126550 IG_V_gene 12 115861867 IG_V_gene 12 114140692 IG_V_gene 6 67791046 IG_V_gene 12 113588267 snRNA 6 129897932 IG_V_gene 6 68704508 IG_V_gene 12 113685482 IG_V_gene 12 114513330 IG_V_gene 6 68519012 IG_V_gene 6 67759700 IG_V_gene 6 70340876 protein_coding 14 5607620 IG_V_gene 6 67942074 IG_V_gene 12 113879096 IG_V_gene 12 113716670 IG_V_gene 12 115495625 protein_coding 17 17064113 processed_pseudogene 10 130592157 IG_V_gene 12 115460999 transcribed_unprocessed_pseudogene 17 6438524 IG_V_gene 12 113807314 IG_V_gene 6 69607275 protein_coding 15 82206168 bidirectional_promoter_lncRNA 8 11477929 lincRNA 4 146509094 lincRNA 18 38238405 lincRNA 1 136670769 lincRNA 9 21717616 processed_transcript 9 88840236 lincRNA 8 84665128 lincRNA 8 19789798 lincRNA 13 63289601 lincRNA 3 70772379 lincRNA 1 185359461 antisense 13 67796594 lincRNA 11 96712982 processed_pseudogene 10 22262742 protein_coding 11 69120054

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

lincRNA 19 6012620 lincRNA 12 80108034 antisense 14 50870324 antisense 12 58953089 processed_transcript 12 109603940 antisense 8 72137389 lincRNA 12 112946363 lincRNA 5 109922649 lincRNA 8 4088149 lincRNA 5 5781530 lincRNA 17 78882042 lincRNA 9 122295869 lincRNA 9 78175914 lincRNA 3 27154026 lincRNA 6 13871526 antisense 15 95787856 sense_overlapping 7 93006982 lincRNA 15 3996039 antisense 10 22187013 processed_pseudogene 3 35863877 lincRNA 19 57323385 lincRNA 8 121850194 lincRNA 2 150748281 antisense 5 45638699 lincRNA 4 3678117 lincRNA 5 109995511 protein_coding 11 67774608 unprocessed_pseudogene 18 43472816 antisense 12 85962598 processed_pseudogene 13 67810246 lincRNA 5 136919146 bidirectional_promoter_lncRNA 6 61172293 lincRNA 8 120204434 antisense 19 47512982 processed_transcript 1 135108497 processed_pseudogene 18 52472848 processed_pseudogene 15 39180511 protein_coding 7 30054489 transcribed_unprocessed_pseudogene 17 94750100 protein_coding 10 59221953 antisense 17 34083843 unprocessed_pseudogene 17 34084672 lincRNA 6 134929092 antisense 8 15015092 antisense 17 52592981 IG_V_gene 6 68736297 transcribed_unprocessed_pseudogene 7 7265498 unprocessed_pseudogene 7 106186404 protein_coding 1 9960163 protein_coding 7 14331436 processed_pseudogene 1 86014403

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

processed_pseudogene 17 21967501 lincRNA 2 116972575 protein_coding 19 46348201 protein_coding 18 35553404 processed_transcript 12 20804381 antisense 1 85933247 unprocessed_pseudogene 15 75071112 lincRNA 16 93391677 lincRNA 17 51986415 lincRNA 1 98131456 processed_pseudogene 1 55335401 protein_coding 13 67069399 processed_transcript 16 93342504 unprocessed_pseudogene 7 39489438 lincRNA 1 151748949 sense_intronic 1 135409622 lincRNA 1 132342023 lincRNA 6 91440987 processed_pseudogene 11 16635109 lincRNA 1 73750321 protein_coding 19 11375523 snRNA 9 83938369 processed_pseudogene 8 75711600 transcribed_processed_pseudogene 1 34415050 protein_coding 1 156524012 unprocessed_pseudogene 7 47733002 unprocessed_pseudogene 1 24612775 protein_coding 9 88956900 processed_pseudogene 1 192888571 TEC 1 191535885 protein_coding 7 59982495 TEC 1 4778063 TEC 1 172388234 IG_V_pseudogene 12 114817099 TEC 2 78972672 IG_V_gene 12 114462291 IG_V_pseudogene 12 114809421 IG_V_gene 12 115067560 protein_coding 1 170277320 TEC 9 103120368 unprocessed_pseudogene 1 177808550 unprocessed_pseudogene 1 178143301 IG_V_pseudogene 12 114812321 protein_coding 18 37819513 lincRNA 3 51378024 IG_V_pseudogene 12 114740408 IG_V_pseudogene 12 114835223 IG_V_pseudogene 12 114736245 antisense 1 136116577 protein_coding 1 170298199 IG_V_pseudogene 12 115371986

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

TEC 3 106725599 processed_pseudogene 1 189277443 TEC 1 155973318 TEC 9 83114108 IG_V_pseudogene 12 113572927 antisense 1 180256429 IG_V_pseudogene 12 114843651 IG_V_pseudogene 12 114781409 IG_V_pseudogene 12 114924941 TEC 1 62809302 IG_V_gene 12 113762249 protein_coding 18 37742094 lincRNA 19 11465250 lincRNA 9 107594440 lincRNA 12 115262684 lincRNA 3 52198248 TEC 2 32487988 processed_pseudogene 1 181282046 IG_V_pseudogene 12 114013144 IG_V_gene 12 114764450 IG_V_pseudogene 12 114033803 transcribed_processed_pseudogene 1 172458569 IG_V_pseudogene 12 114804616 lincRNA 9 107593841 TEC 9 99322826 TEC 3 51672801 TEC 1 175955455 TEC 1 153443481 lincRNA 6 41055883 unprocessed_pseudogene 1 173986926 TEC 8 84200869 TEC 1 66793645 TEC 6 41692640 IG_V_pseudogene 12 114676749 processed_pseudogene 16 32408536 IG_V_pseudogene 12 114910011 IG_V_gene 12 114253617 processed_transcript 1 164863133 lincRNA 1 176276213 lincRNA 6 117716342 TEC 1 176031079 IG_V_pseudogene 12 114646572 processed_transcript 1 138968510 IG_V_gene 12 115294062 processed_pseudogene 1 165643899 antisense 3 122377097 unprocessed_pseudogene 12 115883640 processed_pseudogene 3 57717813 TR_V_pseudogene 14 53926978 antisense 14 54067579 IG_V_pseudogene 6 69463194

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

TEC 5 145292770 IG_V_pseudogene 6 67847409 processed_pseudogene 5 86997159 TEC 5 45556680 TR_C_gene 14 54142851 lincRNA 16 19212660 sense_intronic 3 144197172 processed_pseudogene 6 67883346 IG_V_pseudogene 6 68312062 protein_coding 5 105215699 processed_pseudogene 12 113172487 TEC 16 19231333 TEC 16 19243525 TEC 5 124300484 IG_J_gene 16 19067041 processed_pseudogene 3 126447743 lincRNA 3 138000939 lincRNA 5 64593857 processed_pseudogene 5 137601593 processed_pseudogene 14 52368918 IG_V_pseudogene 6 69110904 transcribed_processed_pseudogene 3 94334394 TEC 5 72554240 IG_C_gene 16 19065230 processed_pseudogene 3 130929366 IG_V_pseudogene 12 116009659 IG_V_gene 6 68302427 TEC 5 122779525 lincRNA 6 70719074 lincRNA 3 143017660 processed_transcript 14 54292443 IG_V_pseudogene 12 115963817 TEC 6 70883354 TR_J_gene 13 19311245 sense_intronic 3 105766966 processed_transcript 3 105959503 IG_C_gene 16 19061618 processed_transcript 5 23698296 unprocessed_pseudogene 5 109551892 unprocessed_pseudogene 12 115934272 TEC 3 116940358 antisense 14 54128298 lincRNA 5 64044978 sense_intronic 5 30815620 processed_pseudogene 5 21613994 antisense 5 52441159 IG_V_pseudogene 6 69197583 IG_V_gene 6 68474613 IG_J_gene 16 19066371 IG_V_pseudogene 12 115933180 TEC 5 25369020

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

IG_V_pseudogene 12 115790593 IG_V_pseudogene 12 115691889 antisense 5 137612852 IG_V_pseudogene 6 68151885 TEC 3 96464072 IG_J_gene 16 19063225 lincRNA 5 147418601 lincRNA 6 18845910 processed_pseudogene 5 147325869 TEC 6 3325742 lincRNA 5 75833035 TEC 5 30868764 transcribed_processed_pseudogene 6 36956802 processed_pseudogene 5 117058812 TEC 5 73311364 processed_pseudogene 7 3181093 lincRNA 6 51283532 TEC 6 129696118 TEC 6 5216258 TEC 6 136847744 TEC 6 83314145 processed_pseudogene 6 63783852 antisense 6 87729964 TEC 6 145863297 TEC 6 145304310 antisense 6 135188480 TEC 6 86663188 unprocessed_pseudogene 7 30926668 TEC 7 127993269 lincRNA 7 24448354 TEC 7 80209394 processed_pseudogene 7 123010112 processed_pseudogene 7 97591693 processed_pseudogene 7 25419153 TEC 7 80344082 TEC 7 73422250 transcribed_processed_pseudogene 7 128314784 TEC 7 80603239 processed_transcript 7 56038866 antisense 6 72120213 TEC 7 34389732 lincRNA 7 100675088 antisense 7 28859587 TEC 7 59327318 lincRNA 7 100542338 transcribed_unprocessed_pseudogene 7 6977246 TEC 7 44894305 TEC 7 18396516 lincRNA 7 19868121 lincRNA 7 88311478 TEC 7 90030571

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

lincRNA 8 10898169 protein_coding 7 44975989 antisense 7 45742049 antisense 7 45567794 processed_pseudogene 8 97876154 transcribed_unprocessed_pseudogene 9 48418321 protein_coding 5 138341961 processed_transcript 8 35724175 TEC 8 27168840 antisense 8 46763251 unprocessed_pseudogene 9 22167479 TEC 8 77574219 TEC 8 90876581 antisense 7 45630664 lincRNA 7 136268324 protein_coding 7 7213017 processed_pseudogene 7 136810909 protein_coding 11 116677483 lincRNA 7 101347409 TEC 8 11457471 antisense 7 45121917 transcribed_unprocessed_pseudogene 19 8473313 processed_pseudogene 8 29286431 antisense 7 45635680 lincRNA 8 85125872 bidirectional_promoter_lncRNA 8 57651757 TEC 8 95045981 processed_pseudogene 8 20122384 lincRNA 8 126839233 lincRNA 8 123165255 processed_pseudogene 8 70010549 processed_pseudogene 8 71704205 antisense 8 94170748 lincRNA 8 121833247 unprocessed_pseudogene 8 20001099 processed_pseudogene 8 19784746 antisense 9 118485559 processed_pseudogene 10 50422134 antisense 9 35188663 processed_pseudogene 19 12528755 antisense 9 40747281 antisense 9 44999429 bidirectional_promoter_lncRNA 9 22260102 lincRNA 10 43824200 processed_pseudogene 10 20365010 lincRNA 9 120004037 lincRNA 9 44579608 TEC 9 37329767 processed_pseudogene 9 31434043 unprocessed_pseudogene 8 69554802 protein_coding 4 43830542

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

TEC 9 44255047 antisense 11 83065752 processed_pseudogene 2 85898910 sense_intronic 9 51215733 TEC 10 118441419 processed_pseudogene 12 10152142 transcribed_processed_pseudogene 10 111500739 processed_pseudogene 12 77623549 lincRNA 12 77039597 processed_pseudogene 12 52079014 processed_pseudogene 10 115599026 lincRNA 10 8176131 lincRNA 10 53409882 processed_pseudogene 10 82430704 antisense 10 122792055 processed_pseudogene 10 51543035 lincRNA 10 118502035 lincRNA 10 111599177 lincRNA 10 99459689 lincRNA 12 80091367 lincRNA 10 117864670 lincRNA 10 17318085 processed_pseudogene 10 82009481 lincRNA 10 118718146 protein_coding 10 81863934 bidirectional_promoter_lncRNA 10 24927619 antisense 10 51489530 antisense 10 54063811 processed_pseudogene 10 85849141 lincRNA 10 51526340 lincRNA 10 79412962 processed_pseudogene 13 16431525 processed_transcript 12 69464787 processed_pseudogene 13 12259793 lincRNA 13 74553910 TEC 13 62734907 TEC 13 3899209 protein_coding 13 49493318 processed_pseudogene 13 64927942 lincRNA 12 71337628 sense_intronic 12 112971745 lincRNA 12 105513480 processed_pseudogene 12 69123101 transcribed_processed_pseudogene 13 61804257 lincRNA 12 70912259 TEC 12 61990302 processed_pseudogene 13 61665941 lincRNA 12 111941991 TEC 13 3562385 processed_pseudogene 13 65243717 TEC 12 19301653

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

lincRNA 12 25181768 protein_coding 13 96079216 lincRNA 12 36326341 lincRNA 13 98994151 antisense 13 93073304 processed_pseudogene 13 38514096 lincRNA 13 106747070 lincRNA 13 67278577 antisense 13 112356925 lincRNA 13 67143672 lincRNA 13 37482385 processed_pseudogene 13 108309202 lincRNA 14 9400624 lincRNA 13 37541357 processed_pseudogene 13 83832340 TEC 13 114281668 processed_pseudogene 13 98613501 processed_pseudogene 14 37722117 lincRNA 13 67226997 lincRNA 13 37581077 processed_pseudogene 13 84281179 antisense 13 93094833 processed_pseudogene 14 51358603 lincRNA 15 37892995 protein_coding 15 76101481 lincRNA 15 34021995 processed_pseudogene 15 59238489 transcribed_processed_pseudogene 14 72840641 processed_pseudogene 14 120713078 lincRNA 15 38184009 lincRNA 15 60120540 lincRNA 14 44544055 lincRNA 14 103012908 processed_pseudogene 15 99413474 processed_pseudogene 15 84182709 processed_pseudogene 15 91960740 TEC 15 76577825 protein_coding 15 76533213 lincRNA 16 3346350 TEC 15 80640458 processed_pseudogene 15 77701997 processed_transcript 15 100730481 unprocessed_pseudogene 17 6511791 antisense 16 94488777 antisense 16 78560316 processed_pseudogene 16 23050282 processed_pseudogene 16 48749400 antisense 16 57338310 unprocessed_pseudogene 17 6339604 processed_pseudogene 17 3312250 lincRNA 17 27354111

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

lincRNA 16 29829456 processed_pseudogene 16 27843362 lincRNA 16 32550211 lincRNA 17 29053336 processed_pseudogene 17 66005705 TEC 17 73514717 protein_coding 17 28726083 processed_pseudogene 17 74211958 processed_pseudogene 17 78750995 processed_pseudogene 17 58803053 processed_pseudogene 17 65438128 antisense 17 12466844 lincRNA 17 71144538 processed_pseudogene 17 48238211 pseudogene 16 21896506

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

from 'F1-Lupus vs B6 Gene.end.(bp) 127152193 45553800 88955465 77565708 121363737 56525032 18514843 80014977 101213684 105970037 55113029 50866208 82774454 123097760 123158315 12672248 52283014 161788495 60005064 54417780 83711348 106388075 61579687 51623714 78352489 8661242 22135711 97115331 4104746 75772364 87932665 109962203 75392512 106034549 16798274 37613722 73824969 44980431 91045729 24422778 104786018 55625395 70212305 10628230 25788705 46725541 38592162 83741326 31329644

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

17888801 19699188 135258568 122845366 61092553 45784669 45704682 98728198 27553218 24902197 13794064 28302238 35704621 20009145 84888221 90390895 91703429 154884501 76668196 17062427 56569103 22879634 131675505 57836793 57483527 135889563 84257326 66969640 69549110 10349180 8710764 106749037 13512269 75100589 110982461 95129209 87816101 110812405 42529330 73224511 73261242 136064326 4480487 130985660 50924893 75617200 113153879 79038353 47259440 25234364 71903858

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

22060305 30955091 30445535 24761923 21960779 166155663 100356128 35046745 35062095 68339711 70504081 143072853 8672155 45621059 82705750 88548300 33956001 22593813 79403569 75895941 83067318 17573980 135607295 79915906 116775507 100599984 114790739 8723369 61149372 181827797 119093502 79527739 26561499 112641360 19496762 107875107 17699748 111338177 60696490 14645056 105708210 71296243 58390728 172206804 30308367 129876672 19861299 105281939 44210326 70712636 122611463

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

96591578 171953170 9487771 89087077 56262260 34823464 46487675 95687917 87371073 45639614 96293969 30491455 139213307 193264075 193035775 36362341 181157014 181018363 194961279 146955614 24477377 83725021 164405160 164415448 164443887 36171259 101190724 76243725 98053462 118449963 99089306 79698023 117839908 164857711 105966097 143710250 23692908 98546031 53467766 87616302 86807746 165473230 69333042 69967885 118199043 69784023 110337716 115277050 54131665 70352031 83522175

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

147936767 21918192 101063719 98455373 69852058 45092221 79955018 47368870 110711606 13131694 51254027 39110188 44148853 67096945 89621253 69291791 68541896 24927484 20361304 20281590 19907689 93519304 93747207 94145339 94590956 95417180 95564146 86349506 86705509 87937042 62143920 60372684 20332713 116389535 19018985 75537381 11898144 111508645 82742428 83534140 54870501 54860916 32222300 32059202 31935634 31370074 54364756 50104758 50238616 46389515 4948064

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

46407982 4441105 134079120 6230143 3452363 5838016 5803733 5542187 5525893 58883288 61762088 90638084 90002894 13583811 8793715 109573330 109995845 28750472 26415254 25097140 105989964 80178958 106288745 72550506 72047370 116654313 71789647 116828046 70731964 94474198 97033958 70057894 69197843 69036473 68816632 68497849 67102291 100148665 102780262 102900912 103101658 65074007 91849157 75735729 76710547 76822908 72940774 73988966 80113013 8871909 99884439

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

101718523 102439813 102565028 6648777 111377718 111966977 112181747 112868228 19632994 21036617 30766976 40960892 41487362 33041884 63497278 64186537 75943925 73620605 89742509 91223968 102739629 100452869 100114571 96670936 104252392 117987418 8666240 111808993 112510086 112652475 21751181 21798726 18038090 19823824 45318771 32062197 119262855 32348151 62372992 62456289 57826185 60764556 78002657 99074540 70289471 118981697 54554616 54781946 54618022 55788865 55944675

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

31029341 25973687 34436273 34530648 59331192 56694539 55520803 85802819 80970946 80700425 80119501 55090491 84315688 82294574 97731339 97767972 82040085 81960930 11320074 11134650 26371841 30550842 75111970 74983430 89591923 45409053 19772753 44333196 43964314 58717636 81626828 17132383 20325404 36875003 78359774 76022281 23360350 97514816 93906115 93604063 91597800 182019990 100687921 37841873 35438689 123750345 134601805 113100981 130279205 113829121 119639471

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

33095865 88826683 124888221 137294466 106350521 55833943 124833701 3193463 32099740 7303315 12507704 12769664 14404790 23611019 23736735 40840754 47392967 47400584 49909847 31277356 31198975 71126856 71311978 71864273 73710453 73832094 73950196 64755110 91093071 25433783 23844172 24410201 86833410 87723713 24839787 55514581 26095508 26508519 27167764 83514333 16809246 34031690 36014715 35649367 34898265 32435736 38464399 35910075 36326155 37997574 46790826

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

46905446 66465550 67319146 67610790 68255549 79109391 57946821 58209926 61085061 61132149 11336146 11604849 18704788 20954202 6091777 36460970 6053712 5366645 4113965 23949597 4943127 5481853 5468498 27254231 37701528 41059523 41743665 46596898 39642673 47692094 57008228 57491005 58860984 120617936 120643769 121039418 42779978 44306864 45530013 45560531 46375252 155340754 140845778 128958282 128891718 128800824 128744855 120047167 77565147 140231145 140882309

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

141276786 141363020 141493427 141539857 121283744 113836386 158043294 116409540 130826319 30073617 74554780 128503363 47813430 55006018 14310235 21298312 16678275 65278695 63596276 62818695 45926523 67038872 66863277 60773359 60567104 59237231 40500854 40317257 37720085 37410736 24100341 74804179 74435559 71653200 75432320 85908675 92986391 90951142 91362416 144775435 140183764 139523752 120121078 138620141 136960448 130814740 135810989 135752232 134151540 134411740 134332928

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

134292548 153332786 151721939 177020437 174248450 173982744 173913046 172478575 164935527 164458355 164220277 164150026 164057677 163313710 156474331 156328035 184999570 191350914 3328877 171126967 170867771 169969241 14332057 49774778 49948849 12301922 23572106 28230736 28039514 58792971 30415813 34961772 35336976 26593120 26123220 51973494 60963192 80581380 71367749 78921293 69114282 84993886 84983632 112263269 104742878 124667770 125258608 126091185 122461137 92615250 122265340

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

92024502 122186189 122056598 121310832 119760431 119354381 119229906 131086765 119147445 118853957 118882909 131525922 117343001 126588243 126676337 127541467 160906002 144590749 144768758 148732467 150931280 151632593 153015427 153687730 154373010 172474331 173218923 174784042 178338492 168742409 14808368 181213185 155074497 155518237 155585724 155592810 32366014 35937445 36565727 54391037 68698547 68626481 56183701 58525892 103912247 101287939 89913196 116129688 127553349 131303227 83841767

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Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

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Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

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114584002 70406992 53666506 115243235 68050456 105493095 70215957 115981134 62383177 113625956 69681975 69858884 147188487 115953005 115567591 102618516 114538965 115145919 113662293 70663895 70588777 70699067 20582771 114616318 113702578 101078567 114487569 68017488 115593591 113770302 113859670 113994898 152910155 113597977 70260955 114060321 12858633 41533212 70704177 114523905 67914052 69649363 114724205 68256869 70371993 114946383 113653724 114896671 119755882 114479451 115834418

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115758461 115446869 116000461 45980037 54122241 145837998 6436296 115869227 67610508 7983383 114417053 114709135 85127514 115862355 114141122 67791511 113588702 129898005 68704978 113686045 114513807 68519477 67760413 70341453 5807982 67942540 113879541 113717103 115496058 17089628 130592705 115461485 6467022 113807752 69607828 82212815 11480241 146511764 38250565 136690804 21723450 88858870 84669406 19798548 63297147 70807291 185362865 67830985 96747436 22263367 69122589

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6018426 80113000 50880603 58968011 109661716 72140820 112950512 109923481 4089166 5783636 78892500 122310928 78178879 27157019 14044385 95791642 93104789 4015858 22302835 35864865 57360775 121860621 150750762 45645469 3689548 109996398 67789898 43475169 85979021 67811200 136937112 61180810 120228230 47516578 135132594 52473739 39181436 30072900 94775132 59226434 34095309 34085823 134956798 15018907 52602660 68736780 7278267 106189999 9967932 14333557 86015886

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21968242 116976428 46350302 35581609 20815779 85937332 75074638 93458872 52163976 98144655 55335796 67108604 93366668 39498801 151755018 135414186 132349626 91441755 16636066 73841917 11392790 83938475 75713196 34417986 156526664 47733940 24613119 88962419 192889042 191536892 60140219 4779212 172390989 114817526 79098851 114462730 114809854 115068002 170286769 103122841 177962233 178144272 114812745 37841873 51386324 114740841 114835656 114736678 136119822 170306332 115372433

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106730276 189277823 155974506 83116864 113573402 180274963 114844083 114781834 114925368 62811857 113762708 37841873 11467055 107594891 115287908 52200489 32492148 181283892 114013606 114764883 114034233 172474969 114805041 107597075 99323516 51673901 175957398 153444300 41063102 174001972 84203049 66796298 41696186 114677181 32409054 114910443 114254051 164936775 176279769 117718868 176032723 114647056 138971851 115294504 165644688 122391811 115884273 57718289 53927595 54125395 69463725

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

145295008 67847874 86998415 45558181 54148868 19236776 144199262 67883610 68312359 105239533 113173306 19234802 19244834 124301827 19067078 126447950 138016044 64610700 137602172 52369688 69111432 94335332 72555229 19065681 130930670 116010093 68303158 122786097 70740554 143040752 54297456 115964250 70885802 19311304 105770197 105984600 19062071 23712667 109554156 115934904 116944330 54146287 64050228 30818477 21614494 52443252 69198116 68475101 19066408 115933491 25373039

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

115791027 115692322 137615247 68152617 96466924 19063262 147423044 18848207 147326334 3327855 75835645 30870828 36959888 117059392 73312560 3181888 51287855 129696485 5220486 136848249 83316943 63784067 87731148 145865172 145305183 135194960 86665551 30927147 127996598 24451327 80211678 123010622 97592402 25419826 80347993 73423902 128340805 80603783 56049974 72123197 34393612 100677760 28876331 59331189 100543180 6991087 44898099 18400865 19871438 88315864 90032916

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10900558 44986568 45750257 45575327 97876520 48431959 138343557 35757517 27171012 46764973 22170652 77575568 90878476 45633077 136318513 7278289 136812515 116681290 101347984 11459742 45124144 8541798 29286981 45638765 85132289 57663430 95047460 20122494 126851473 123178765 70011002 71704968 94173412 121841178 20008736 19784856 118489099 50422808 35193817 12530540 40762673 45002985 22263289 43833392 20365437 120005106 44584652 37334429 31434707 69585162 43840201

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44258293 83071246 85900544 51219521 118444140 10158233 111501965 77625009 77042201 52079311 115600328 8193340 53424272 82432393 122792483 51546848 118556525 111611338 99488610 80101172 117868075 17323228 82009800 118719428 81881081 24930059 51522447 54065069 85850866 51531161 79417905 16431780 69475550 12260270 74564256 62737195 3900248 49496589 64929161 71342803 112972145 105515246 69123780 61861675 70914485 61991769 61667140 111944484 3563618 65243867 19305191

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

25189630 96081376 36331936 98997418 93074757 38514875 106761579 67283361 112367845 67145366 37483150 108310750 9459180 37549725 83833336 114284381 98614494 37722937 67229969 37589313 84281816 93098968 51359964 37899716 76120195 34037780 59239002 72863555 120713666 38202217 60187408 44637201 103024457 99413693 84183015 91963518 76580863 76535366 3348370 80642408 77703044 100732737 6528713 94522117 78564869 23050851 48750448 57340403 6361848 3314185 27367492

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

29834728 27844412 32553708 29060167 66006087 73517755 28726700 74214082 78751496 58803626 65438697 12479578 71181987 48240641 21897116

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

s B6-Old Female Mice' (|FC|1.5, FDR<0.05) Gene.description cyclin D2 [Source:MGI Symbol;Acc:MGI:88314] guanosine monophosphate reductase [Source:MGI Symbol;Acc:MGI:1913605] serine carboxypeptidase 1 [Source:MGI Symbol;Acc:MGI:1921867] integrin beta 2 [Source:MGI Symbol;Acc:MGI:96611] creatine kinase, mitochondrial 1, ubiquitous [Source:MGI Symbol;Acc:MGI:99441] ring finger protein 17 [Source:MGI Symbol;Acc:MGI:1353419] cortactin binding protein 2 [Source:MGI Symbol;Acc:MGI:1353467] platelet derived growth factor, B polypeptide [Source:MGI Symbol;Acc:MGI:97528] activin A receptor, type 1B [Source:MGI Symbol;Acc:MGI:1338944] WD repeat domain 77 [Source:MGI Symbol;Acc:MGI:1917715] GM2 ganglioside activator protein [Source:MGI Symbol;Acc:MGI:95762] glutamate receptor, metabotropic 6 [Source:MGI Symbol;Acc:MGI:1351343] hexokinase 2 [Source:MGI Symbol;Acc:MGI:1315197] SPG7, paraplegin matrix AAA peptidase subunit [Source:MGI Symbol;Acc:MGI:2385906] sulfotransferase family 5A, member 1 [Source:MGI Symbol;Acc:MGI:1931463] tubulin, gamma complex associated protein 3 [Source:MGI Symbol;Acc:MGI:2183752] transcription factor 7, T cell specific [Source:MGI Symbol;Acc:MGI:98507] (TNF superfamily, member 6) [Source:MGI Symbol;Acc:MGI:99255] predicted gene, 38393 [Source:MGI Symbol;Acc:MGI:5613898] solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 [Source:MGI Symbol;Acc:MGI:133 WAP four-disulfide core domain 18 [Source:MGI Symbol;Acc:MGI:107506] intercellular adhesion molecule 2 [Source:MGI Symbol;Acc:MGI:96394] epsin 2 [Source:MGI Symbol;Acc:MGI:1333766] NHP2 ribonucleoprotein [Source:MGI Symbol;Acc:MGI:1098547] 1-acylglycerol-3-phosphate O-acyltransferase 3 [Source:MGI Symbol;Acc:MGI:1336186] ephrin B2 [Source:MGI Symbol;Acc:MGI:105097] 5, tartrate resistant [Source:MGI Symbol;Acc:MGI:87883] T-box 21 [Source:MGI Symbol;Acc:MGI:1888984] cytochrome P450, family 51 [Source:MGI Symbol;Acc:MGI:106040] elongation factor RNA polymerase II 2 [Source:MGI Symbol;Acc:MGI:2183438] casein kappa [Source:MGI Symbol;Acc:MGI:107461] MARVEL (membrane-associating) domain containing 3 [Source:MGI Symbol;Acc:MGI:1920858] latent transforming growth factor beta binding protein 1 [Source:MGI Symbol;Acc:MGI:109151] potassium voltage-gated channel, subfamily H (eag-related), member 6 [Source:MGI Symbol;Acc:MGI:2684139] solute carrier family 1 (neutral amino acid transporter), member 5 [Source:MGI Symbol;Acc:MGI:105305] sperm autoantigenic protein 17 [Source:MGI Symbol;Acc:MGI:1333778] PDZ domain containing 4 [Source:MGI Symbol;Acc:MGI:2443483] CD3 antigen, gamma polypeptide [Source:MGI Symbol;Acc:MGI:88333] receptor-associated protein of the synapse [Source:MGI Symbol;Acc:MGI:99422] smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans) [Source:MGI Symbol;Acc:MGI:1919247] protein phosphatase 1J [Source:MGI Symbol;Acc:MGI:1919137] REC8 meiotic recombination protein [Source:MGI Symbol;Acc:MGI:1929645] solute carrier family 25, member 42 [Source:MGI Symbol;Acc:MGI:1920345] small nuclear ribonucleoprotein D1 [Source:MGI Symbol;Acc:MGI:98344] AXL receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:1347244] peroxisomal biogenesis factor 6 [Source:MGI Symbol;Acc:MGI:2385054] transmembrane protein 39a [Source:MGI Symbol;Acc:MGI:1915096] adhesion G protein-coupled receptor E5 [Source:MGI Symbol;Acc:MGI:1347095] laminin B1 [Source:MGI Symbol;Acc:MGI:96743]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

CD36 molecule [Source:MGI Symbol;Acc:MGI:107899] apolipoprotein E [Source:MGI Symbol;Acc:MGI:88057] E74-like factor 3 [Source:MGI Symbol;Acc:MGI:1101781] forkhead box J2 [Source:MGI Symbol;Acc:MGI:1926805] G protein-coupled receptor kinase 5 [Source:MGI Symbol;Acc:MGI:109161] sulfotransferase family, cytosolic, 2B, member 1 [Source:MGI Symbol;Acc:MGI:1926342] carbonic anhydrase 11 [Source:MGI Symbol;Acc:MGI:1336193] FK506 binding protein 11 [Source:MGI Symbol;Acc:MGI:1913370] family, member 3 [Source:MGI Symbol;Acc:MGI:1333782] CD79A antigen (immunoglobulin-associated alpha) [Source:MGI Symbol;Acc:MGI:101774] ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 [Source:MGI Symbol;Acc:MGI:2386797] delta like canonical Notch ligand 3 [Source:MGI Symbol;Acc:MGI:1096877] discoidin domain receptor family, member 1 [Source:MGI Symbol;Acc:MGI:99216] [Source:MGI Symbol;Acc:MGI:88476] synaptonemal complex central element protein 2 [Source:MGI Symbol;Acc:MGI:1919096] hepatic leukemia factor [Source:MGI Symbol;Acc:MGI:96108] single-stranded DNA binding protein 2 [Source:MGI Symbol;Acc:MGI:1914220] calcium channel, voltage-dependent, R type, alpha 1E subunit [Source:MGI Symbol;Acc:MGI:106217] kinesin family member C2 [Source:MGI Symbol;Acc:MGI:109187] hypoxia inducible factor 3, alpha subunit [Source:MGI Symbol;Acc:MGI:1859778] phosphodiesterase 1C [Source:MGI Symbol;Acc:MGI:108413] DnaJ heat shock (Hsp40) member B11 [Source:MGI Symbol;Acc:MGI:1915088] E [Source:MGI Symbol;Acc:MGI:107361] AT rich interactive domain 3B (BRIGHT-like) [Source:MGI Symbol;Acc:MGI:1930768] adhesion G protein-coupled receptor E1 [Source:MGI Symbol;Acc:MGI:106912] heat shock protein 1 [Source:MGI Symbol;Acc:MGI:96240] methylthioribose-1-phosphate 1 [Source:MGI Symbol;Acc:MGI:1915123] N-myc downstream regulated gene 1 [Source:MGI Symbol;Acc:MGI:1341799] dynein, axonemal, heavy chain 2 [Source:MGI Symbol;Acc:MGI:107731] prolactin receptor [Source:MGI Symbol;Acc:MGI:97763] solute carrier family 1 (glial high affinity ), member 3 [Source:MGI Symbol;Acc:MGI:99917 interleukin 5 receptor, alpha [Source:MGI Symbol;Acc:MGI:96558] nidogen 1 [Source:MGI Symbol;Acc:MGI:97342] heme oxygenase 1 [Source:MGI Symbol;Acc:MGI:96163] MRV integration site 1 [Source:MGI Symbol;Acc:MGI:1338023] [Source:MGI Symbol;Acc:MGI:1355285] -related receptor [Source:MGI Symbol;Acc:MGI:1346037] adenosine monophosphate deaminase 3 [Source:MGI Symbol;Acc:MGI:1096344] SH2 domain containing 1A [Source:MGI Symbol;Acc:MGI:1328352] sedoheptulokinase [Source:MGI Symbol;Acc:MGI:1921887] transient receptor potential cation channel, subfamily V, member 1 [Source:MGI Symbol;Acc:MGI:1341787] uroplakin 3B-like [Source:MGI Symbol;Acc:MGI:1916915] EPS8-like 1 [Source:MGI Symbol;Acc:MGI:1914675] HtrA serine peptidase 1 [Source:MGI Symbol;Acc:MGI:1929076] O-sialoglycoprotein [Source:MGI Symbol;Acc:MGI:1913496] gamma-glutamyltransferase 5 [Source:MGI Symbol;Acc:MGI:1346063] cysteine-rich protein 1 (intestinal) [Source:MGI Symbol;Acc:MGI:88501] glycine C-acetyltransferase (2-amino-3-ketobutyrate- ) [Source:MGI Symbol;Acc:MGI:1349389 neuralized E3 ubiquitin protein ligase 1A [Source:MGI Symbol;Acc:MGI:1334263] solute carrier family 34 (sodium phosphate), member 3 [Source:MGI Symbol;Acc:MGI:2159410] pyruvate dehydrogenase kinase, isoenzyme 1 [Source:MGI Symbol;Acc:MGI:1926119]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

ATPase, Cu++ transporting, beta polypeptide [Source:MGI Symbol;Acc:MGI:103297] abhydrolase domain containing 1 [Source:MGI Symbol;Acc:MGI:1931013] amyloid beta (A4) precursor-like protein 1 [Source:MGI Symbol;Acc:MGI:88046] geminin [Source:MGI Symbol;Acc:MGI:1927344] zinc finger protein 184 (Kruppel-like) [Source:MGI Symbol;Acc:MGI:1922244] 2 [Source:MGI Symbol;Acc:MGI:1919293] huntingtin-associated protein 1 [Source:MGI Symbol;Acc:MGI:1261831] mutS homolog 5 [Source:MGI Symbol;Acc:MGI:1329021] dimethylarginine dimethylaminohydrolase 2 [Source:MGI Symbol;Acc:MGI:1859016] melanocortin 5 receptor [Source:MGI Symbol;Acc:MGI:99420] cytokine receptor-like factor 1 [Source:MGI Symbol;Acc:MGI:1340030] U2 small nuclear ribonucleoprotein B [Source:MGI Symbol;Acc:MGI:104805] calcium regulated heat stable protein 1 [Source:MGI Symbol;Acc:MGI:1196368] fucosyltransferase 1 [Source:MGI Symbol;Acc:MGI:109375] /B [Source:MGI Symbol;Acc:MGI:103188] RAB25, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:1858203] ribosomal protein S18 [Source:MGI Symbol;Acc:MGI:98146] voltage-dependent anion channel 3 [Source:MGI Symbol;Acc:MGI:106922] transmembrane protein 184b [Source:MGI Symbol;Acc:MGI:2445179] Der1-like domain family, member 3 [Source:MGI Symbol;Acc:MGI:1917627] DEAQ RNA-dependent ATPase [Source:MGI Symbol;Acc:MGI:2136388] met proto-oncogene [Source:MGI Symbol;Acc:MGI:96969] neuron navigator 1 [Source:MGI Symbol;Acc:MGI:2183683] apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 [Source:MGI Symbol;Acc:MGI:1933111] ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 [S POU domain, class 6, transcription factor 1 [Source:MGI Symbol;Acc:MGI:102935] kinesin family member 19A [Source:MGI Symbol;Acc:MGI:2447024] solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 [Source:MGI Symbol;A tumor necrosis factor receptor superfamily, member 13b [Source:MGI Symbol;Acc:MGI:1889411] myelin transcription factor 1 [Source:MGI Symbol;Acc:MGI:1100535] , delta 1 [Source:MGI Symbol;Acc:MGI:97614] KDEL (Lys-Asp-Glu-Leu) protein retention receptor 3 [Source:MGI Symbol;Acc:MGI:21459 RIKEN cDNA 1700049J03 gene [Source:MGI Symbol;Acc:MGI:1920615] adenylosuccinate synthetase like 1 [Source:MGI Symbol;Acc:MGI:87947] exocyst complex component 3-like 2 [Source:MGI Symbol;Acc:MGI:1921713] ecotropic viral integration site 5 [Source:MGI Symbol;Acc:MGI:104736] M-phase specific PLK1 intereacting protein [Source:MGI Symbol;Acc:MGI:1913558] mixed lineage kinase domain-like [Source:MGI Symbol;Acc:MGI:1921818] cadherin 23 (otocadherin) [Source:MGI Symbol;Acc:MGI:1890219] angiomotin-like 1 [Source:MGI Symbol;Acc:MGI:1922973] enkurin domain containing 1 [Source:MGI Symbol;Acc:MGI:2142593] aldehyde dehydrogenase family 1, subfamily A2 [Source:MGI Symbol;Acc:MGI:107928] LY6/PLAUR domain containing 8 [Source:MGI Symbol;Acc:MGI:1917413] phosphoprotein enriched in astrocytes 15A [Source:MGI Symbol;Acc:MGI:104799] CAP-GLY domain containing linker protein 3 [Source:MGI Symbol;Acc:MGI:1923936] killer cell lectin-like receptor, subfamily A, member 17 [Source:MGI Symbol;Acc:MGI:2180674] carcinoembryonic antigen-related cell adhesion molecule 16 [Source:MGI Symbol;Acc:MGI:2685615] nucleolar protein 3 (apoptosis repressor with CARD domain) [Source:MGI Symbol;Acc:MGI:1925938] DnaJ heat shock protein family (Hsp40) member B9 [Source:MGI Symbol;Acc:MGI:1351618] golgi reassembly stacking protein 2 [Source:MGI Symbol;Acc:MGI:2135962] galactosamine (N-acetyl)-6-sulfate sulfatase [Source:MGI Symbol;Acc:MGI:1355303]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

cytochrome P450, family 2, subfamily j, polypeptide 9 [Source:MGI Symbol;Acc:MGI:1921769] SLAM family member 6 [Source:MGI Symbol;Acc:MGI:1353620] cytochrome b-245, beta polypeptide [Source:MGI Symbol;Acc:MGI:88574] TraB domain containing [Source:MGI Symbol;Acc:MGI:1915226] B [Source:MGI Symbol;Acc:MGI:109267] complement component 4A (Rodgers blood group) [Source:MGI Symbol;Acc:MGI:98320] tau tubulin kinase 1 [Source:MGI Symbol;Acc:MGI:2147036] ADAMTS-like 4 [Source:MGI Symbol;Acc:MGI:2389008] CD5 antigen-like [Source:MGI Symbol;Acc:MGI:1334419] family with sequence similarity 184, member B [Source:MGI Symbol;Acc:MGI:2442958] Fc receptor, IgG, high affinity I [Source:MGI Symbol;Acc:MGI:95498] calcium channel, voltage-dependent, L type, alpha 1D subunit [Source:MGI Symbol;Acc:MGI:88293] serine/threonine kinase 32C [Source:MGI Symbol;Acc:MGI:2385336] hydroxysteroid 11-beta dehydrogenase 1 [Source:MGI Symbol;Acc:MGI:103562] synaptotagmin XIV [Source:MGI Symbol;Acc:MGI:2444490] LON peptidase N-terminal domain and ring finger 3 [Source:MGI Symbol;Acc:MGI:1921615] eukaryotic translation elongation factor 1 alpha 2 [Source:MGI Symbol;Acc:MGI:1096317] collagen, type XX, alpha 1 [Source:MGI Symbol;Acc:MGI:1920618] CD34 antigen [Source:MGI Symbol;Acc:MGI:88329] general transcription factor III A [Source:MGI Symbol;Acc:MGI:1913846] cytidine monophospho-N-acetylneuraminic acid hydroxylase [Source:MGI Symbol;Acc:MGI:103227] signal peptide, CUB domain, EGF-like 1 [Source:MGI Symbol;Acc:MGI:1890616] matrilin 4 [Source:MGI Symbol;Acc:MGI:1328314] recombination signal binding protein for immunoglobulin kappa J region-like [Source:MGI Symbol;Acc:MGI:1196 syndecan 4 [Source:MGI Symbol;Acc:MGI:1349164] interleukin 13 receptor, alpha 1 [Source:MGI Symbol;Acc:MGI:105052] contactin associated protein-like 1 [Source:MGI Symbol;Acc:MGI:1858201] glyoxalase domain containing 4 [Source:MGI Symbol;Acc:MGI:1914451] SH3 and cysteine rich domain 2 [Source:MGI Symbol;Acc:MGI:2144518] C1q and tumor necrosis factor related protein 1 [Source:MGI Symbol;Acc:MGI:1919254] tensin 4 [Source:MGI Symbol;Acc:MGI:2144377] RAB11 family interacting protein 4 (class II) [Source:MGI Symbol;Acc:MGI:2442920] arylformamidase [Source:MGI Symbol;Acc:MGI:2448704] phospholipid transfer protein [Source:MGI Symbol;Acc:MGI:103151] solute carrier family 12, member 4 [Source:MGI Symbol;Acc:MGI:1309465] cytohesin 3 [Source:MGI Symbol;Acc:MGI:1335107] histone cluster 1, H2bc [Source:MGI Symbol;Acc:MGI:1915274] IKAROS family zinc finger 3 [Source:MGI Symbol;Acc:MGI:1342542] shroom family member 1 [Source:MGI Symbol;Acc:MGI:1919024] myotubularin related protein 4 [Source:MGI Symbol;Acc:MGI:2180699] DEAH (Asp-Glu-Ala-His) box polypeptide 40 [Source:MGI Symbol;Acc:MGI:1914737] solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 [Source:MGI Symbol;Acc:MGI potassium voltage-gated channel, shaker-related subfamily, beta member 3 [Source:MGI Symbol;Acc:MGI:1336 claudin 7 [Source:MGI Symbol;Acc:MGI:1859285] dynein, axonemal, heavy chain 11 [Source:MGI Symbol;Acc:MGI:1100864] zinc finger and BTB domain containing 4 [Source:MGI Symbol;Acc:MGI:1922830] ATP-binding cassette, sub-family A (ABC1), member 5 [Source:MGI Symbol;Acc:MGI:2386607] ferredoxin reductase [Source:MGI Symbol;Acc:MGI:104724] procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide [Source:MGI Sym arachidonate 15-lipoxygenase [Source:MGI Symbol;Acc:MGI:87997] HEAT repeat containing 9 [Source:MGI Symbol;Acc:MGI:3650286]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 [Source:MGI Symbol;Acc:MGI:99907] RAB3D, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:97844] ATPase, H+ transporting, lysosomal V0 subunit A1 [Source:MGI Symbol;Acc:MGI:103286] growth factor receptor bound protein 7 [Source:MGI Symbol;Acc:MGI:102683] phospholipid scramblase 3 [Source:MGI Symbol;Acc:MGI:1917560] reticulocalbin 3, EF-hand calcium binding domain [Source:MGI Symbol;Acc:MGI:1277122] AT rich interactive domain 3A (BRIGHT-like) [Source:MGI Symbol;Acc:MGI:1328360] sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A [Source:MGI Symbol;Ac coiled-coil domain containing 12 [Source:MGI Symbol;Acc:MGI:1919904] pleiomorphic adenoma gene-like 1 [Source:MGI Symbol;Acc:MGI:1100874] S-adenosylmethionine decarboxylase, pseudogene 4 [Source:MGI Symbol;Acc:MGI:3650439] laminin, alpha 4 [Source:MGI Symbol;Acc:MGI:109321] crystallin beta-gamma domain containing 1 [Source:MGI Symbol;Acc:MGI:109544] receptor accessory protein 3 [Source:MGI Symbol;Acc:MGI:88930] solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 [Source:MGI Symbo Rho-related BTB domain containing 1 [Source:MGI Symbol;Acc:MGI:1916538] ciliary associated calcium binding coiled-coil 1 [Source:MGI Symbol;Acc:MGI:1920537] arginase, liver [Source:MGI Symbol;Acc:MGI:88070] mitochondrial fission regulator 2 [Source:MGI Symbol;Acc:MGI:1919054] microtubule-associated protein 7 [Source:MGI Symbol;Acc:MGI:1328328] peroxisomal biogenesis factor 7 [Source:MGI Symbol;Acc:MGI:1321392] ammonia [Source:MGI Symbol;Acc:MGI:96010] netrin 4 [Source:MGI Symbol;Acc:MGI:1888978] FYVE, RhoGEF and PH domain containing 6 [Source:MGI Symbol;Acc:MGI:1261419] transmembrane and coiled coil domains 3 [Source:MGI Symbol;Acc:MGI:2442900] suppressor of cytokine signaling 2 [Source:MGI Symbol;Acc:MGI:1201787] nudix (nucleoside diphosphate linked moiety X)-type motif 4 [Source:MGI Symbol;Acc:MGI:1918457] tissue inhibitor of metalloproteinase 3 [Source:MGI Symbol;Acc:MGI:98754] heat shock protein 90, beta (Grp94), member 1 [Source:MGI Symbol;Acc:MGI:98817] insulin-like growth factor 1 [Source:MGI Symbol;Acc:MGI:96432] family with sequence similarity 241, member B [Source:MGI Symbol;Acc:MGI:1917144] V-set immunoregulatory receptor [Source:MGI Symbol;Acc:MGI:1921298] solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 [Source:MGI Symbol;Acc:MGI:213 protein tyrosine phosphatase, receptor type, B [Source:MGI Symbol;Acc:MGI:97809] Meis homeobox 1 [Source:MGI Symbol;Acc:MGI:104717] small nuclear ribonucleoprotein D3 [Source:MGI Symbol;Acc:MGI:1914582] dopa decarboxylase [Source:MGI Symbol;Acc:MGI:94876] pleckstrin like domain, family A, member 1 [Source:MGI Symbol;Acc:MGI:1096880] host cell factor C2 [Source:MGI Symbol;Acc:MGI:1915183] aldehyde dehydrogenase 1 family, member L2 [Source:MGI Symbol;Acc:MGI:2444680] histidine triad binding protein 1 [Source:MGI Symbol;Acc:MGI:1321133] LYR motif containing 7 [Source:MGI Symbol;Acc:MGI:1922780] rhomboid 5 homolog 1 [Source:MGI Symbol;Acc:MGI:104328] neuron specific gene family member 2 [Source:MGI Symbol;Acc:MGI:1202070] cytoplasmic polyadenylation element binding protein 4 [Source:MGI Symbol;Acc:MGI:1914829] stanniocalcin 2 [Source:MGI Symbol;Acc:MGI:1316731] acyl-CoA synthetase long-chain family member 6 [Source:MGI Symbol;Acc:MGI:894291] ring finger protein 130 [Source:MGI Symbol;Acc:MGI:1891717] leukotriene C4 synthase [Source:MGI Symbol;Acc:MGI:107498] IL2 inducible T cell kinase [Source:MGI Symbol;Acc:MGI:96621] , heavy polypeptide [Source:MGI Symbol;Acc:MGI:97309]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

family with sequence similarity 71, member B [Source:MGI Symbol;Acc:MGI:3650836] HORMA domain containing 2 [Source:MGI Symbol;Acc:MGI:1923078] B cell translocation gene 2, anti-proliferative [Source:MGI Symbol;Acc:MGI:108384] NPC1 like intracellular cholesterol transporter 1 [Source:MGI Symbol;Acc:MGI:2685089] ring finger protein 185 [Source:MGI Symbol;Acc:MGI:1922078] polymerase (DNA directed), mu [Source:MGI Symbol;Acc:MGI:1860191] phosphoglycerate mutase 2 [Source:MGI Symbol;Acc:MGI:1933118] coiled-coil domain containing 117 [Source:MGI Symbol;Acc:MGI:2144383] X-box binding protein 1 [Source:MGI Symbol;Acc:MGI:98970] RIKEN cDNA 2810021J22 gene [Source:MGI Symbol;Acc:MGI:1917194] phosphoribosyl pyrophosphate synthetase-associated protein 2 [Source:MGI Symbol;Acc:MGI:2384838] syntaxin binding protein 4 [Source:MGI Symbol;Acc:MGI:1342296] phosphatidylcholine transfer protein [Source:MGI Symbol;Acc:MGI:107375] neuroblastoma amplified sequence [Source:MGI Symbol;Acc:MGI:1918419] syndecan 1 [Source:MGI Symbol;Acc:MGI:1349162] G [Source:MGI Symbol;Acc:MGI:1921258] ATP-binding cassette, sub-family A (ABC1), member 8b [Source:MGI Symbol;Acc:MGI:1351668] trafficking protein particle complex 12 [Source:MGI Symbol;Acc:MGI:2445089] ring finger protein 144A [Source:MGI Symbol;Acc:MGI:1344401] inhibitor of DNA binding 2 [Source:MGI Symbol;Acc:MGI:96397] angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 [Source:MGI Symbol;Acc:MGI:87874] ArfGAP with dual PH domains 2 [Source:MGI Symbol;Acc:MGI:2663075] testicular cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:1923120] spinster homolog 3 [Source:MGI Symbol;Acc:MGI:1924827] PICALM interacting mitotic regulator [Source:MGI Symbol;Acc:MGI:1924434] cytoglobin [Source:MGI Symbol;Acc:MGI:2149481] WSC domain containing 1 [Source:MGI Symbol;Acc:MGI:2448493] matrix-remodelling associated 7 [Source:MGI Symbol;Acc:MGI:1914872] kinesin family member 1C [Source:MGI Symbol;Acc:MGI:1098260] calcium channel, voltage-dependent, T type, alpha 1G subunit [Source:MGI Symbol;Acc:MGI:1201678] secernin 2 [Source:MGI Symbol;Acc:MGI:1343092] asialoglycoprotein receptor 1 [Source:MGI Symbol;Acc:MGI:88081] arachidonate 8-lipoxygenase [Source:MGI Symbol;Acc:MGI:1098228] CTS telomere maintenance complex component 1 [Source:MGI Symbol;Acc:MGI:1916214] myosin, heavy polypeptide 10, non-muscle [Source:MGI Symbol;Acc:MGI:1930780] phosphoinositide-3-kinase regulatory subunit 5 [Source:MGI Symbol;Acc:MGI:2443588] myosin, heavy polypeptide 3, , embryonic [Source:MGI Symbol;Acc:MGI:1339709] [Source:MGI Symbol;Acc:MGI:96693] a disintegrin and metallopeptidase domain 11 [Source:MGI Symbol;Acc:MGI:1098667] glial fibrillary acidic protein [Source:MGI Symbol;Acc:MGI:95697] phospholipase C, delta 3 [Source:MGI Symbol;Acc:MGI:107451] FK506 binding protein 3 [Source:MGI Symbol;Acc:MGI:1353460] sel-1 suppressor of lin-12-like (C. elegans) [Source:MGI Symbol;Acc:MGI:1329016] sphingosine-1-phosphate phosphatase 1 [Source:MGI Symbol;Acc:MGI:2135760] spectrin beta, erythrocytic [Source:MGI Symbol;Acc:MGI:98387] RAB15, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:1916865] RIKEN cDNA 4930447C04 gene [Source:MGI Symbol;Acc:MGI:1923051] small nuclear RNA activating complex, polypeptide 1 [Source:MGI Symbol;Acc:MGI:1922877] zinc finger protein 36, C3H type-like 1 [Source:MGI Symbol;Acc:MGI:107946] WD repeat domain 37 [Source:MGI Symbol;Acc:MGI:1920393] EF-hand calcium binding domain 11 [Source:MGI Symbol;Acc:MGI:1926017]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

tandem C2 domains, nuclear [Source:MGI Symbol;Acc:MGI:1921663] legumain [Source:MGI Symbol;Acc:MGI:1330838] chromogranin A [Source:MGI Symbol;Acc:MGI:88394] phosphofructokinase, platelet [Source:MGI Symbol;Acc:MGI:1891833] CDC42 binding protein kinase beta [Source:MGI Symbol;Acc:MGI:2136459] ATP synthase membrane subunit 6.8PL [Source:MGI Symbol;Acc:MGI:1917507] kinesin family member 26A [Source:MGI Symbol;Acc:MGI:2447072] G protein-coupled receptor 132 [Source:MGI Symbol;Acc:MGI:1890220] secreted frizzled-related protein 4 [Source:MGI Symbol;Acc:MGI:892010] acyloxyacyl [Source:MGI Symbol;Acc:MGI:1350928] interferon regulatory factor 4 [Source:MGI Symbol;Acc:MGI:1096873] glucosaminyl (N-acetyl) transferase 2, I-branching enzyme [Source:MGI Symbol;Acc:MGI:1100870] neural precursor cell expressed, developmentally down-regulated gene 9 [Source:MGI Symbol;Acc:MGI:97302] serine (or cysteine) peptidase inhibitor, clade B, member 9b [Source:MGI Symbol;Acc:MGI:894668] Fanconi anemia, complementation group C [Source:MGI Symbol;Acc:MGI:95480] hyaluronic acid binding protein 4 [Source:MGI Symbol;Acc:MGI:1891713] Rho-related BTB domain containing 3 [Source:MGI Symbol;Acc:MGI:1920546] CLPTM1-like [Source:MGI Symbol;Acc:MGI:2442892] versican [Source:MGI Symbol;Acc:MGI:102889] autophagy related 10 [Source:MGI Symbol;Acc:MGI:1914045] CD180 antigen [Source:MGI Symbol;Acc:MGI:1194924] NLR family, apoptosis inhibitory protein 1 [Source:MGI Symbol;Acc:MGI:1298223] small EDRK-rich factor 1 [Source:MGI Symbol;Acc:MGI:1337114] 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [Source:MGI Symbol;Acc:MGI:96159] centromere protein K [Source:MGI Symbol;Acc:MGI:1926210] hyperpolarization-activated, cyclic nucleotide-gated K+ 1 [Source:MGI Symbol;Acc:MGI:1096392] RIKEN cDNA 4930452B06 gene [Source:MGI Symbol;Acc:MGI:1926154] mitogen-activated protein kinase kinase kinase 1 [Source:MGI Symbol;Acc:MGI:1346872] signal transducer [Source:MGI Symbol;Acc:MGI:96560] DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 [Source:MGI Symbol;Acc:MGI:102670] dual specificity phosphatase 13 [Source:MGI Symbol;Acc:MGI:1351599] sterile alpha motif domain containing 8 [Source:MGI Symbol;Acc:MGI:1914880] beta [Source:MGI Symbol;Acc:MGI:98743] RNA transcription, translation and transport factor [Source:MGI Symbol;Acc:MGI:1915295] ERO1-like (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1354385] polypeptide N-acetylgalactosaminyltransferase 15 [Source:MGI Symbol;Acc:MGI:1926004] predicted gene 6768 [Source:MGI Symbol;Acc:MGI:3648259] oxoglutarate dehydrogenase-like [Source:MGI Symbol;Acc:MGI:3616088] H2, subunit B [Source:MGI Symbol;Acc:MGI:1914403] guanylate cyclase 1, soluble, beta 2 [Source:MGI Symbol;Acc:MGI:2660873] spindle and kinetochore associated complex subunit 3 [Source:MGI Symbol;Acc:MGI:3041235] spermatogenesis associated 13 [Source:MGI Symbol;Acc:MGI:104838] epithelial stromal interaction 1 (breast) [Source:MGI Symbol;Acc:MGI:1915168] bora, aurora kinase A activator [Source:MGI Symbol;Acc:MGI:1924994] protein phosphatase 3, catalytic subunit, gamma isoform [Source:MGI Symbol;Acc:MGI:107162] DnaJ heat shock protein family (Hsp40) member C3 [Source:MGI Symbol;Acc:MGI:107373] HAUS augmin-like complex, subunit 4 [Source:MGI Symbol;Acc:MGI:1261794] solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 [Source:MGI Symbol;Acc:MGI:135 proteasome (prosome, macropain) subunit, beta type 5 [Source:MGI Symbol;Acc:MGI:1194513] receptor-interacting serine-threonine kinase 3 [Source:MGI Symbol;Acc:MGI:2154952] chymase 1, mast cell [Source:MGI Symbol;Acc:MGI:96941]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

catenin (cadherin associated protein), delta 2 [Source:MGI Symbol;Acc:MGI:1195966] reticulophagy regulator 1 [Source:MGI Symbol;Acc:MGI:1913520] matrilin 2 [Source:MGI Symbol;Acc:MGI:109613] processing of precursor 1, /MRP family, (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1914974] squalene epoxidase [Source:MGI Symbol;Acc:MGI:109296] hyaluronan synthase 2 [Source:MGI Symbol;Acc:MGI:107821] collagen, type XIV, alpha 1 [Source:MGI Symbol;Acc:MGI:1341272] peroxisome proliferator activated receptor alpha [Source:MGI Symbol;Acc:MGI:104740] adenylosuccinate lyase [Source:MGI Symbol;Acc:MGI:103202] family with sequence similarity 83, member F [Source:MGI Symbol;Acc:MGI:2146227] synaptogyrin 1 [Source:MGI Symbol;Acc:MGI:1328323] DNA replication and sister chromatid cohesion 1 [Source:MGI Symbol;Acc:MGI:1919357] parvin, beta [Source:MGI Symbol;Acc:MGI:2153063] septin 3 [Source:MGI Symbol;Acc:MGI:1345148] endonuclease, polyU-specific [Source:MGI Symbol;Acc:MGI:97746] Rap guanine nucleotide exchange factor (GEF) 3 [Source:MGI Symbol;Acc:MGI:2441741] X-ray repair complementing defective repair in Chinese hamster cells 6 [Source:MGI Symbol;Acc:MGI:95606] phosphomannomutase 1 [Source:MGI Symbol;Acc:MGI:1353418] tumor necrosis factor receptor superfamily, member 17 [Source:MGI Symbol;Acc:MGI:1343050] thioredoxin domain containing 11 [Source:MGI Symbol;Acc:MGI:1923620] claudin 1 [Source:MGI Symbol;Acc:MGI:1276109] transmembrane protein 44 [Source:MGI Symbol;Acc:MGI:1924489] lymphocyte antigen 6 complex, locus C2 [Source:MGI Symbol;Acc:MGI:3712069] lymphocyte antigen 6 complex, locus I [Source:MGI Symbol;Acc:MGI:1888480] RAB, member RAS oncogene family-like 2 [Source:MGI Symbol;Acc:MGI:1915958] CD200 antigen [Source:MGI Symbol;Acc:MGI:1196990] UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 [Source:MGI Symbol;Acc:MGI:2137302] SID1 transmembrane family, member 1 [Source:MGI Symbol;Acc:MGI:2443155] coiled-coil domain containing 191 [Source:MGI Symbol;Acc:MGI:1922661] coproporphyrinogen oxidase [Source:MGI Symbol;Acc:MGI:104841] neural cell adhesion molecule 2 [Source:MGI Symbol;Acc:MGI:97282] stromal cell-derived factor 2-like 1 [Source:MGI Symbol;Acc:MGI:2149842] cytochrome P450, family 2, subfamily ab, polypeptide 1 [Source:MGI Symbol;Acc:MGI:3644957] ELL associated factor 2 [Source:MGI Symbol;Acc:MGI:2146616] coxsackie virus and adenovirus receptor [Source:MGI Symbol;Acc:MGI:1201679] SAM domain, SH3 domain and nuclear localization signals, 1 [Source:MGI Symbol;Acc:MGI:1914992] beta galactoside alpha 2,6 sialyltransferase 1 [Source:MGI Symbol;Acc:MGI:108470] family with sequence similarity 3, member B [Source:MGI Symbol;Acc:MGI:1270150] chromatin assembly factor 1, subunit B (p60) [Source:MGI Symbol;Acc:MGI:1314881] SET domain containing 4 [Source:MGI Symbol;Acc:MGI:2136890] transmembrane protein 50B [Source:MGI Symbol;Acc:MGI:1925225] ENAH actin regulator [Source:MGI Symbol;Acc:MGI:108360] -like family, member 1 [Source:MGI Symbol;Acc:MGI:95314] protocadherin gamma subfamily C, 4 [Source:MGI Symbol;Acc:MGI:1935203] centrosomal protein 89 [Source:MGI Symbol;Acc:MGI:1919390] akirin 1 [Source:MGI Symbol;Acc:MGI:1915300] replication factor C (activator 1) 2 [Source:MGI Symbol;Acc:MGI:1341868] granzyme A [Source:MGI Symbol;Acc:MGI:109266] serine incorporator 2 [Source:MGI Symbol;Acc:MGI:1919132] secretogranin V [Source:MGI Symbol;Acc:MGI:98289] guanylate cyclase activator 2a (guanylin) [Source:MGI Symbol;Acc:MGI:102738]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

gamma-aminobutyric acid (GABA) C receptor, subunit rho 2 [Source:MGI Symbol;Acc:MGI:95626] cysteine-rich with EGF-like domains 2 [Source:MGI Symbol;Acc:MGI:1923987] CD4 antigen [Source:MGI Symbol;Acc:MGI:88335] acetylcholinesterase [Source:MGI Symbol;Acc:MGI:87876] POC1 centriolar protein A [Source:MGI Symbol;Acc:MGI:1917485] nuclear factor of activated T cells, cytoplasmic, dependent 4 [Source:MGI Symbol;Acc:MGI:1920431] cell division cycle associated 3 [Source:MGI Symbol;Acc:MGI:1315198] Sfi1 homolog, spindle assembly associated (yeast) [Source:MGI Symbol;Acc:MGI:1926137] phosphatidylinositol glycan anchor biosynthesis, class X [Source:MGI Symbol;Acc:MGI:1919334] ribosomal protein S6 kinase, polypeptide 2 [Source:MGI Symbol;Acc:MGI:1342290] solute carrier family 22 (organic cation transporter), member 3 [Source:MGI Symbol;Acc:MGI:1333817] insulin-like growth factor 2 receptor [Source:MGI Symbol;Acc:MGI:96435] SPARC related modular calcium binding 2 [Source:MGI Symbol;Acc:MGI:1929881] zinc finger and SCAN domain containing 10 [Source:MGI Symbol;Acc:MGI:3040700] protein kinase, membrane associated tyrosine/threonine 1 [Source:MGI Symbol;Acc:MGI:2137630] Rhesus blood group-associated A glycoprotein [Source:MGI Symbol;Acc:MGI:1202713] guanylate cyclase activator 1B [Source:MGI Symbol;Acc:MGI:1194489] guanylate cyclase activator 1a () [Source:MGI Symbol;Acc:MGI:102770] kinesin family member 6 [Source:MGI Symbol;Acc:MGI:1098238] radial spoke head 1 homolog (Chlamydomonas) [Source:MGI Symbol;Acc:MGI:1194909] transmembrane protease, serine 3 [Source:MGI Symbol;Acc:MGI:2155445] myomesin 1 [Source:MGI Symbol;Acc:MGI:1341430] elastin microfibril interfacer 2 [Source:MGI Symbol;Acc:MGI:2389136] CAP-GLY domain containing linker protein family, member 4 [Source:MGI Symbol;Acc:MGI:1919100] polypeptide N-acetylgalactosaminyltransferase 14 [Source:MGI Symbol;Acc:MGI:1918935] EH-domain containing 3 [Source:MGI Symbol;Acc:MGI:1928900] xanthine dehydrogenase [Source:MGI Symbol;Acc:MGI:98973] mannosidase 2, alpha 1 [Source:MGI Symbol;Acc:MGI:104669] neurexin I [Source:MGI Symbol;Acc:MGI:1096391] calcium channel, voltage-dependent, T type, alpha 1H subunit [Source:MGI Symbol;Acc:MGI:1928842] protease, serine 41 [Source:MGI Symbol;Acc:MGI:1918253] ATP-binding cassette, sub-family A (ABC1), member 3 [Source:MGI Symbol;Acc:MGI:1351617] endothelial PAS domain protein 1 [Source:MGI Symbol;Acc:MGI:109169] mutS homolog 2 [Source:MGI Symbol;Acc:MGI:101816] meiosis specific with OB domains [Source:MGI Symbol;Acc:MGI:1922428] beta galactoside alpha 2,6 sialyltransferase 2 [Source:MGI Symbol;Acc:MGI:2445190] NME/NM23 nucleoside diphosphate kinase 4 [Source:MGI Symbol;Acc:MGI:1931148] dual specificity phosphatase 1 [Source:MGI Symbol;Acc:MGI:105120] inositol hexaphosphate kinase 3 [Source:MGI Symbol;Acc:MGI:3045325] cytochrome c oxidase subunit 7A2 like [Source:MGI Symbol;Acc:MGI:106015] cadherin 2 [Source:MGI Symbol;Acc:MGI:88355] solute carrier family 39 (zinc transporter), member 7 [Source:MGI Symbol;Acc:MGI:95909] pleckstrin and Sec7 domain containing 2 [Source:MGI Symbol;Acc:MGI:1921252] marginal zone B and B1 cell-specific protein 1 [Source:MGI Symbol;Acc:MGI:1917066] complement component 2 (within H-2S) [Source:MGI Symbol;Acc:MGI:88226] bridging integrator 1 [Source:MGI Symbol;Acc:MGI:108092] Nedd4 family interacting protein 1 [Source:MGI Symbol;Acc:MGI:1929601] alpha tubulin acetyltransferase 1 [Source:MGI Symbol;Acc:MGI:1913869] histocompatibility 2, M region locus 10.1 [Source:MGI Symbol;Acc:MGI:1276522] ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [Source:MGI Symbol;Acc:MGI:2147274] adaptor-related protein complex 3, sigma 1 subunit [Source:MGI Symbol;Acc:MGI:1337062]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

laeverin [Source:MGI Symbol;Acc:MGI:1921824] phorbol-12-myristate-13-acetate-induced protein 1 [Source:MGI Symbol;Acc:MGI:1930146] inositol (myo)-1(or 4)-monophosphatase 2 [Source:MGI Symbol;Acc:MGI:2149728] spire type actin nucleation factor 1 [Source:MGI Symbol;Acc:MGI:1915416] low density lipoprotein receptor class A domain containing 4 [Source:MGI Symbol;Acc:MGI:1277150] SET binding protein 1 [Source:MGI Symbol;Acc:MGI:1933199] solute carrier family 12, member 2 [Source:MGI Symbol;Acc:MGI:101924] fibrillin 2 [Source:MGI Symbol;Acc:MGI:95490] platelet derived growth factor receptor, beta polypeptide [Source:MGI Symbol;Acc:MGI:97531] colony stimulating factor 1 receptor [Source:MGI Symbol;Acc:MGI:1339758] membrane-spanning 4-domains, subfamily A, member 7 [Source:MGI Symbol;Acc:MGI:1918846] membrane-spanning 4-domains, subfamily A, member 6D [Source:MGI Symbol;Acc:MGI:1916024] carnosine N-methyltransferase 1 [Source:MGI Symbol;Acc:MGI:1914633] transmembrane channel-like gene family 1 [Source:MGI Symbol;Acc:MGI:2151016] cell division cycle associated 5 [Source:MGI Symbol;Acc:MGI:1915099] polycomb group ring finger 5 [Source:MGI Symbol;Acc:MGI:1923505] synovial apoptosis inhibitor 1, synoviolin [Source:MGI Symbol;Acc:MGI:1921376] barrier to autointegration factor 1 [Source:MGI Symbol;Acc:MGI:1346330] phosphatidylinositol transfer protein, membrane-associated 1 [Source:MGI Symbol;Acc:MGI:1197524] amyloid beta (A4) precursor protein binding, family A, member 1 [Source:MGI Symbol;Acc:MGI:1860297] pellino 3 [Source:MGI Symbol;Acc:MGI:1924963] epidermal growth factor-containing fibulin-like extracellular matrix protein 2 [Source:MGI Symbol;Acc:MGI:1891 cathepsin W [Source:MGI Symbol;Acc:MGI:1338045] very low density lipoprotein receptor [Source:MGI Symbol;Acc:MGI:98935] cytochrome P450, family 26, subfamily a, polypeptide 1 [Source:MGI Symbol;Acc:MGI:1096359] deoxynucleotidyltransferase, terminal [Source:MGI Symbol;Acc:MGI:98659] slit guidance ligand 1 [Source:MGI Symbol;Acc:MGI:1315203] sideroflexin 2 [Source:MGI Symbol;Acc:MGI:2137678] macrophage scavenger receptor 1 [Source:MGI Symbol;Acc:MGI:98257] collagen, type XVII, alpha 1 [Source:MGI Symbol;Acc:MGI:88450] actin filament associated protein 1-like 2 [Source:MGI Symbol;Acc:MGI:2147658] TruB pseudouridine (psi) synthase family member 1 [Source:MGI Symbol;Acc:MGI:1919383] heat shock protein 12A [Source:MGI Symbol;Acc:MGI:1920692] phosphate cytidylyltransferase 2, ethanolamine [Source:MGI Symbol;Acc:MGI:1915921] pyrroline-5-carboxylate reductase 1 [Source:MGI Symbol;Acc:MGI:2384795] CD7 antigen [Source:MGI Symbol;Acc:MGI:88344] HPS1, biogenesis of lysosomal organelles complex 3 subunit 1 [Source:MGI Symbol;Acc:MGI:2177763] stearoyl-Coenzyme A desaturase 2 [Source:MGI Symbol;Acc:MGI:98240] beta-transducin repeat containing protein [Source:MGI Symbol;Acc:MGI:1338871] polymerase (DNA directed), lambda [Source:MGI Symbol;Acc:MGI:1889000] major facilitator superfamily domain containing 13a [Source:MGI Symbol;Acc:MGI:1922396] peroxiredoxin 4 [Source:MGI Symbol;Acc:MGI:1859815] peptidyl arginine deiminase, type I [Source:MGI Symbol;Acc:MGI:1338893] integrin alpha 7 [Source:MGI Symbol;Acc:MGI:102700] growth differentiation factor 11 [Source:MGI Symbol;Acc:MGI:1338027] matrix metallopeptidase 19 [Source:MGI Symbol;Acc:MGI:1927899] diacylglycerol kinase, alpha [Source:MGI Symbol;Acc:MGI:102952] apoptosis-associated tyrosine kinase [Source:MGI Symbol;Acc:MGI:1197518] ring finger protein 165 [Source:MGI Symbol;Acc:MGI:2444521] CD163 molecule-like 1 [Source:MGI Symbol;Acc:MGI:2443796] sirtuin 3 [Source:MGI Symbol;Acc:MGI:1927665]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

cadherin-related family member 5 [Source:MGI Symbol;Acc:MGI:1919290] EPS8-like 2 [Source:MGI Symbol;Acc:MGI:2138828] tetraspanin 4 [Source:MGI Symbol;Acc:MGI:1928097] chitinase domain containing 1 [Source:MGI Symbol;Acc:MGI:1915288] FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived) [Source:MGI Symbol;Acc:MGI:24 dachshund family transcription factor 2 [Source:MGI Symbol;Acc:MGI:1890446] connector enhancer of kinase suppressor of Ras 2 [Source:MGI Symbol;Acc:MGI:2661175] membrane-associated ring finger (C3HC4) 8 [Source:MGI Symbol;Acc:MGI:1919029] syndecan 3 [Source:MGI Symbol;Acc:MGI:1349163] thymidylate synthase [Source:MGI Symbol;Acc:MGI:98878] solute carrier organic anion transporter family, member 3a1 [Source:MGI Symbol;Acc:MGI:1351867] neuropilin 1 [Source:MGI Symbol;Acc:MGI:106206] protein disulfide isomerase associated 4 [Source:MGI Symbol;Acc:MGI:104864] unc-5 netrin receptor A [Source:MGI Symbol;Acc:MGI:894682] EYA transcriptional coactivator and phosphatase 1 [Source:MGI Symbol;Acc:MGI:109344] predicted gene 4956 [Source:MGI Symbol;Acc:MGI:3647976] transmembrane protein 70 [Source:MGI Symbol;Acc:MGI:1915068] phosphoinositide kinase, FYVE type zinc finger containing [Source:MGI Symbol;Acc:MGI:1335106] a disintegrin and metallopeptidase domain 23 [Source:MGI Symbol;Acc:MGI:1345162] neuropilin 2 [Source:MGI Symbol;Acc:MGI:1100492] solute carrier family 40 (iron-regulated transporter), member 1 [Source:MGI Symbol;Acc:MGI:1315204] LanC (bacterial lantibiotic synthetase component C)-like 1 [Source:MGI Symbol;Acc:MGI:1336997] acyl-Coenzyme A dehydrogenase, long-chain [Source:MGI Symbol;Acc:MGI:87866] CD28 antigen [Source:MGI Symbol;Acc:MGI:88327] Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 [Source:MGI Symbol;Acc:MGI:1924550] alsin Rho guanine nucleotide exchange factor [Source:MGI Symbol;Acc:MGI:1921268] interleukin 18 receptor 1 [Source:MGI Symbol;Acc:MGI:105383] interleukin 1 receptor, type I [Source:MGI Symbol;Acc:MGI:96545] RIKEN cDNA 2010300C02 gene [Source:MGI Symbol;Acc:MGI:1919347] inositol polyphosphate-4-phosphatase, type I [Source:MGI Symbol;Acc:MGI:1931123] family with sequence similarity 135, member A [Source:MGI Symbol;Acc:MGI:1915437] wingless-type MMTV integration site family, member 10A [Source:MGI Symbol;Acc:MGI:108071] villin 1 [Source:MGI Symbol;Acc:MGI:98930] fibronectin 1 [Source:MGI Symbol;Acc:MGI:95566] SPEG complex locus [Source:MGI Symbol;Acc:MGI:109282] integral membrane protein 2C [Source:MGI Symbol;Acc:MGI:1927594] G protein-coupled receptor 35 [Source:MGI Symbol;Acc:MGI:1929509] melanophilin [Source:MGI Symbol;Acc:MGI:2176380] kelch-like 30 [Source:MGI Symbol;Acc:MGI:1918038] regulator of G-protein signaling 18 [Source:MGI Symbol;Acc:MGI:1927498] complement component factor h [Source:MGI Symbol;Acc:MGI:88385] coagulation factor XIII, beta subunit [Source:MGI Symbol;Acc:MGI:88379] diazepam binding inhibitor [Source:MGI Symbol;Acc:MGI:94865] NIMA (never in gene a)-related expressed kinase 7 [Source:MGI Symbol;Acc:MGI:1890645] nuclear receptor subfamily 5, group A, member 2 [Source:MGI Symbol;Acc:MGI:1346834] Fc receptor, IgA, IgM, high affinity [Source:MGI Symbol;Acc:MGI:1927803] troponin I, skeletal, slow 1 [Source:MGI Symbol;Acc:MGI:105073] cysteine and glycine-rich protein 1 [Source:MGI Symbol;Acc:MGI:88549] chitinase 1 (chitotriosidase) [Source:MGI Symbol;Acc:MGI:1919134] cytochrome b5 reductase 1 [Source:MGI Symbol;Acc:MGI:1919267] protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 [Source:M

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

[Source:MGI Symbol;Acc:MGI:97276] laminin, gamma 1 [Source:MGI Symbol;Acc:MGI:99914] family with sequence similarity 129, member A [Source:MGI Symbol;Acc:MGI:2137237] serologically defined colon cancer antigen 8 [Source:MGI Symbol;Acc:MGI:1924066] spectrin alpha, erythrocytic 1 [Source:MGI Symbol;Acc:MGI:98385] interferon activated gene 202B [Source:MGI Symbol;Acc:MGI:1347083] interferon activated gene 211 [Source:MGI Symbol;Acc:MGI:3041120] SLAM family member 9 [Source:MGI Symbol;Acc:MGI:1923692] chemokine (C motif) ligand 1 [Source:MGI Symbol;Acc:MGI:104593] ATPase, Na+/K+ transporting, beta 1 polypeptide [Source:MGI Symbol;Acc:MGI:88108] coagulation factor V [Source:MGI Symbol;Acc:MGI:88382] selectin, platelet [Source:MGI Symbol;Acc:MGI:98280] selectin, endothelial cell [Source:MGI Symbol;Acc:MGI:98278] paired related homeobox 1 [Source:MGI Symbol;Acc:MGI:97712] sterol O-acyltransferase 1 [Source:MGI Symbol;Acc:MGI:104665] nephrosis 2, podocin [Source:MGI Symbol;Acc:MGI:2157018] MAP/microtubule affinity regulating kinase 1 [Source:MGI Symbol;Acc:MGI:2664902] transmembrane protein 206 [Source:MGI Symbol;Acc:MGI:1914200] N-myristoyltransferase 2 [Source:MGI Symbol;Acc:MGI:1202298] cilia and flagella associated protein 126 [Source:MGI Symbol;Acc:MGI:1922722] activating transcription factor 6 [Source:MGI Symbol;Acc:MGI:1926157] hydroxysteroid (17-beta) dehydrogenase 7 [Source:MGI Symbol;Acc:MGI:1330808] , C type 1 [Source:MGI Symbol;Acc:MGI:97142] kinesin family member 5C [Source:MGI Symbol;Acc:MGI:1098269] LY6/PLAUR domain containing 6B [Source:MGI Symbol;Acc:MGI:1919147] integrin alpha 8 [Source:MGI Symbol;Acc:MGI:109442] speckle-type POZ protein-like [Source:MGI Symbol;Acc:MGI:1924107] olfactomedin 1 [Source:MGI Symbol;Acc:MGI:1860437] collagen, type V, alpha 1 [Source:MGI Symbol;Acc:MGI:88457] uridine phosphorylase 2 [Source:MGI Symbol;Acc:MGI:1923904] carnitine acetyltransferase [Source:MGI Symbol;Acc:MGI:109501] TNF receptor-associated factor 1 [Source:MGI Symbol;Acc:MGI:101836] stomatin [Source:MGI Symbol;Acc:MGI:95403] EGF-like domain 7 [Source:MGI Symbol;Acc:MGI:2449923] nucleus accumbens associated 2, BEN and BTB (POZ) domain containing [Source:MGI Symbol;Acc:MGI:1915241] N-myc (and STAT) interactor [Source:MGI Symbol;Acc:MGI:1928368] RNA binding motif, single stranded interacting protein 1 [Source:MGI Symbol;Acc:MGI:1861774] NCK-associated protein 1 [Source:MGI Symbol;Acc:MGI:1355333] solute carrier family 25 (, Aralar), member 12 [Source:MGI Symbol;Acc:MGI:1926080] ubiquitin-conjugating enzyme E2E 3 [Source:MGI Symbol;Acc:MGI:107412] ceramide synthase 6 [Source:MGI Symbol;Acc:MGI:2442564] proteoglycan 3 [Source:MGI Symbol;Acc:MGI:1858200] proteoglycan 2, bone marrow [Source:MGI Symbol;Acc:MGI:103294] NOP10 ribonucleoprotein [Source:MGI Symbol;Acc:MGI:1913431] DEP domain containing 7 [Source:MGI Symbol;Acc:MGI:2139258] sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D [Source:MGI Symbol;Ac deoxyuridine triphosphatase [Source:MGI Symbol;Acc:MGI:1346051] fibroblast growth factor 7 [Source:MGI Symbol;Acc:MGI:95521] solute carrier family 28 (sodium-coupled ), member 2 [Source:MGI Symbol;Acc:MGI:1913 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 [Source:MGI Symbol;Acc:MGI:1924219] sorbitol dehydrogenase [Source:MGI Symbol;Acc:MGI:98266]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

cAMP responsive element binding protein 3-like 1 [Source:MGI Symbol;Acc:MGI:1347062] protein associated with topoisomerase II homolog 2 (yeast) [Source:MGI Symbol;Acc:MGI:1914828] eukaryotic translation initiation factor 3, subunit J1 [Source:MGI Symbol;Acc:MGI:1925905] microtubule-associated protein 1 A [Source:MGI Symbol;Acc:MGI:1306776] leukocyte tyrosine kinase [Source:MGI Symbol;Acc:MGI:96840] ChaC, cation transport regulator 1 [Source:MGI Symbol;Acc:MGI:1916315] protein phosphatase 1, regulatory inhibitor subunit 14D [Source:MGI Symbol;Acc:MGI:1919362] sialic acid binding Ig-like lectin 1, sialoadhesin [Source:MGI Symbol;Acc:MGI:99668] RAD51 recombinase [Source:MGI Symbol;Acc:MGI:97890] kinetochore-localized astrin/SPAG5 binding [Source:MGI Symbol;Acc:MGI:1289298] isovaleryl coenzyme A dehydrogenase [Source:MGI Symbol;Acc:MGI:1929242] spermine oxidase [Source:MGI Symbol;Acc:MGI:2445356] RAS guanyl releasing protein 1 [Source:MGI Symbol;Acc:MGI:1314635] solute carrier family 27 (fatty acid transporter), member 2 [Source:MGI Symbol;Acc:MGI:1347099] GA repeat binding protein, beta 1 [Source:MGI Symbol;Acc:MGI:95611] prominin 2 [Source:MGI Symbol;Acc:MGI:2138997] lipin 3 [Source:MGI Symbol;Acc:MGI:1891342] SEC23 homolog B, COPII coat complex component [Source:MGI Symbol;Acc:MGI:1350925] D-tyrosyl-tRNA deacylase 1 [Source:MGI Symbol;Acc:MGI:1913294] N-ethylmaleimide sensitive fusion protein attachment protein beta [Source:MGI Symbol;Acc:MGI:104562] GINS complex subunit 1 (Psf1 homolog) [Source:MGI Symbol;Acc:MGI:1916520] syntaphilin [Source:MGI Symbol;Acc:MGI:2139270] and DNA damage regulated 1 [Source:MGI Symbol;Acc:MGI:1915809] DNA methyltransferase 3B [Source:MGI Symbol;Acc:MGI:1261819] CDK5 regulatory subunit associated protein 1 [Source:MGI Symbol;Acc:MGI:1914221] family with sequence similarity 209 [Source:MGI Symbol;Acc:MGI:1923676] Z-DNA binding protein 1 [Source:MGI Symbol;Acc:MGI:1927449] endothelin 3 [Source:MGI Symbol;Acc:MGI:95285] phosphatase and actin regulator 3 [Source:MGI Symbol;Acc:MGI:1921439] ATPase, class II, type 9A [Source:MGI Symbol;Acc:MGI:1330826] carbonic anhydrase 1 [Source:MGI Symbol;Acc:MGI:88268] src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites [Source:MGI Symbol S-adenosylhomocysteine hydrolase [Source:MGI Symbol;Acc:MGI:87968] gamma-glutamyltransferase 7 [Source:MGI Symbol;Acc:MGI:1913385] acyl-CoA synthetase short-chain family member 2 [Source:MGI Symbol;Acc:MGI:1890410] [Source:MGI Symbol;Acc:MGI:95852] zinc finger matrin type 3 [Source:MGI Symbol;Acc:MGI:1195270] DCN1, defective in neddylation 1, domain containing 1 (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:21503 exosome component 9 [Source:MGI Symbol;Acc:MGI:1355319] periostin, osteoblast specific factor [Source:MGI Symbol;Acc:MGI:1926321] interleukin 12a [Source:MGI Symbol;Acc:MGI:96539] schwannomin interacting protein 1 [Source:MGI Symbol;Acc:MGI:1353557] neurobeachin [Source:MGI Symbol;Acc:MGI:1347075] stress-associated endoplasmic reticulum protein 1 [Source:MGI Symbol;Acc:MGI:92638] protein tyrosine phosphatase, non-receptor type 22 (lymphoid) [Source:MGI Symbol;Acc:MGI:107170] CD2 antigen [Source:MGI Symbol;Acc:MGI:88320] interleukin 6 receptor, alpha [Source:MGI Symbol;Acc:MGI:105304] vascular cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:98926] La ribonucleoprotein domain family, member 7 [Source:MGI Symbol;Acc:MGI:107634] cytochrome P450, family 2, subfamily u, polypeptide 1 [Source:MGI Symbol;Acc:MGI:1918769] toll-like receptor 2 [Source:MGI Symbol;Acc:MGI:1346060]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

platelet-derived growth factor, C polypeptide [Source:MGI Symbol;Acc:MGI:1859631] alpha-kinase 1 [Source:MGI Symbol;Acc:MGI:1918731] ephrin A4 [Source:MGI Symbol;Acc:MGI:106643] zinc finger and BTB domain containing 7B [Source:MGI Symbol;Acc:MGI:102755] sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semap polyamine-modulated factor 1 [Source:MGI Symbol;Acc:MGI:1914287] SH2 domain containing 2A [Source:MGI Symbol;Acc:MGI:1351596] doublecortin-like kinase 2 [Source:MGI Symbol;Acc:MGI:1918012] ribosomal protein S3A1 [Source:MGI Symbol;Acc:MGI:1202063] F-box and WD-40 domain protein 7 [Source:MGI Symbol;Acc:MGI:1354695] breast cancer anti-estrogen resistance 3 [Source:MGI Symbol;Acc:MGI:1352501] transmembrane protein 56 [Source:MGI Symbol;Acc:MGI:1923195] transformation related protein 53 inducible nuclear protein 1 [Source:MGI Symbol;Acc:MGI:1926609] family with sequence similarity 92, member A [Source:MGI Symbol;Acc:MGI:1915349] matrix metallopeptidase 16 [Source:MGI Symbol;Acc:MGI:1276107] failed axon connections homolog [Source:MGI Symbol;Acc:MGI:1923382] thiosulfate ()-like domain containing 3 [Source:MGI Symbol;Acc:MGI:1924282] guanylate binding protein 3 [Source:MGI Symbol;Acc:MGI:1926263] PDZ and LIM domain 5 [Source:MGI Symbol;Acc:MGI:1927489] ubiquitin-conjugating enzyme E2J 1 [Source:MGI Symbol;Acc:MGI:1926245] Ras-related GTP binding D [Source:MGI Symbol;Acc:MGI:1098604] Eph receptor A7 [Source:MGI Symbol;Acc:MGI:95276] STRA6-like [Source:MGI Symbol;Acc:MGI:1921402] transmembrane protein with EGF-like and two -like domains 1 [Source:MGI Symbol;Acc:MGI:1926810] tumor necrosis factor (ligand) superfamily, member 8 [Source:MGI Symbol;Acc:MGI:88328] UDP-glucose ceramide glucosyltransferase [Source:MGI Symbol;Acc:MGI:1332243] B-box and SPRY domain containing [Source:MGI Symbol;Acc:MGI:2177191] aminolevulinate, delta-, dehydratase [Source:MGI Symbol;Acc:MGI:96853] solute carrier family 44, member 1 [Source:MGI Symbol;Acc:MGI:2140592] transmembrane protein 38B [Source:MGI Symbol;Acc:MGI:1098718] unc-13 homolog B [Source:MGI Symbol;Acc:MGI:1342278] tropomyosin 2, beta [Source:MGI Symbol;Acc:MGI:98810] glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase [Source:MGI Symbol;Acc:MGI:1354951] SH3-domain GRB2-like (endophilin) interacting protein 1 [Source:MGI Symbol;Acc:MGI:1920344] integrin beta 3 binding protein (beta3-endonexin) [Source:MGI Symbol;Acc:MGI:1914983] cyclin dependent kinase inhibitor 2C [Source:MGI Symbol;Acc:MGI:105388] transcription elongation factor A (SII) N-terminal and central domain containing 2 [Source:MGI Symbol;Acc:MGI: immunodeficiency virus type I enhancer binding protein 3 [Source:MGI Symbol;Acc:MGI:106589] erythroblast membrane-associated protein [Source:MGI Symbol;Acc:MGI:1349816] NADH:ubiquinone oxidoreductase core subunit S5 [Source:MGI Symbol;Acc:MGI:1890889] peptidylprolyl isomerase E (cyclophilin E) [Source:MGI Symbol;Acc:MGI:1917118] Eph receptor B2 [Source:MGI Symbol;Acc:MGI:99611] ring finger protein 220 [Source:MGI Symbol;Acc:MGI:1913993] coiled-coil domain containing 163 [Source:MGI Symbol;Acc:MGI:1915644] peroxiredoxin 1 [Source:MGI Symbol;Acc:MGI:99523] MAP kinase-interacting serine/threonine kinase 1 [Source:MGI Symbol;Acc:MGI:894316] perlecan (heparan sulfate proteoglycan 2) [Source:MGI Symbol;Acc:MGI:96257] , liver/bone/kidney [Source:MGI Symbol;Acc:MGI:87983] guanine nucleotide binding protein, alpha transducing 3 [Source:MGI Symbol;Acc:MGI:3588268] adhesion G protein-coupled receptor B2 [Source:MGI Symbol;Acc:MGI:2451244] coiled coil domain containing 28B [Source:MGI Symbol;Acc:MGI:1913514]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

sperm tail PG rich repeat containing 1 [Source:MGI Symbol;Acc:MGI:1926056] 1 [Source:MGI Symbol;Acc:MGI:96739] exostoses (multiple)-like 1 [Source:MGI Symbol;Acc:MGI:1888742] CD164 sialomucin-like 2 [Source:MGI Symbol;Acc:MGI:1916905] FGR proto-oncogene, Src family tyrosine kinase [Source:MGI Symbol;Acc:MGI:95527] sphingomyelin phosphodiesterase, acid-like 3B [Source:MGI Symbol;Acc:MGI:1916022] protein tyrosine phosphatase, receptor type, U [Source:MGI Symbol;Acc:MGI:1321151] mitochondrial trans-2-enoyl-CoA reductase [Source:MGI Symbol;Acc:MGI:1349441] peptidyl arginine deiminase, type II [Source:MGI Symbol;Acc:MGI:1338892] protein kinase, AMP-activated, gamma 2 non-catalytic subunit [Source:MGI Symbol;Acc:MGI:1336153] Parkinson disease (autosomal recessive, early onset) 7 [Source:MGI Symbol;Acc:MGI:2135637] tumor necrosis factor receptor superfamily, member 9 [Source:MGI Symbol;Acc:MGI:1101059] ERBB receptor feedback inhibitor 1 [Source:MGI Symbol;Acc:MGI:1921405] cortistatin [Source:MGI Symbol;Acc:MGI:109538] ATP-binding cassette, sub-family B (MDR/TAP), member 8 [Source:MGI Symbol;Acc:MGI:1351667] mannan-binding lectin serine peptidase 2 [Source:MGI Symbol;Acc:MGI:1330832] angiopoietin-like 7 [Source:MGI Symbol;Acc:MGI:3605801] RAD50 interactor 1 [Source:MGI Symbol;Acc:MGI:1916233] F-box protein 44 [Source:MGI Symbol;Acc:MGI:1354744] dorsal inhibitory axon guidance protein [Source:MGI Symbol;Acc:MGI:1917683] angiotensin II, type I receptor-associated protein [Source:MGI Symbol;Acc:MGI:1339977] chloride channel, voltage-sensitive 6 [Source:MGI Symbol;Acc:MGI:1347049] migration and invasion inhibitory protein [Source:MGI Symbol;Acc:MGI:106506] gamma-aminobutyric acid (GABA) A receptor, subunit delta [Source:MGI Symbol;Acc:MGI:95622] CD38 antigen [Source:MGI Symbol;Acc:MGI:107474] RIKEN cDNA 5730480H06 gene [Source:MGI Symbol;Acc:MGI:1917842] sortilin-related VPS10 domain containing receptor 2 [Source:MGI Symbol;Acc:MGI:1932289] actin-binding LIM protein 2 [Source:MGI Symbol;Acc:MGI:2385758] HtrA serine peptidase 3 [Source:MGI Symbol;Acc:MGI:1925808] mannosidase 2, alpha B2 [Source:MGI Symbol;Acc:MGI:1195262] , regulatory subunit B, gamma [Source:MGI Symbol;Acc:MGI:2442660] EvC ciliary complex subunit 1 [Source:MGI Symbol;Acc:MGI:1890596] microtubule-associated protein, RP/EB family, member 3 [Source:MGI Symbol;Acc:MGI:2140967] peroxisome proliferative activated receptor, gamma, coactivator 1 alpha [Source:MGI Symbol;Acc:MGI:1342774 dihydropyrimidinase-like 5 [Source:MGI Symbol;Acc:MGI:1929772] transcriptional adaptor 2B [Source:MGI Symbol;Acc:MGI:3035274] gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4 [Source:MGI Symbol;Acc:MGI:95616] ubiquitin carboxy-terminal hydrolase [Source:MGI Symbol;Acc:MGI:103149] Eph receptor A5 [Source:MGI Symbol;Acc:MGI:99654] signal transducing adaptor family member 1 [Source:MGI Symbol;Acc:MGI:1926193] zinc finger protein 326 [Source:MGI Symbol;Acc:MGI:1927246] guanylate-binding protein 9 [Source:MGI Symbol;Acc:MGI:3605620] glycerol-3-phosphate acyltransferase 3 [Source:MGI Symbol;Acc:MGI:3603816] crystallin, beta B1 [Source:MGI Symbol;Acc:MGI:104992] afamin [Source:MGI Symbol;Acc:MGI:2429409] chemokine (C-X-C motif) ligand 1 [Source:MGI Symbol;Acc:MGI:108068] cyclin-dependent kinase-like 2 (CDC2-related kinase) [Source:MGI Symbol;Acc:MGI:1858227] USO1 vesicle docking factor [Source:MGI Symbol;Acc:MGI:1929095] intraflagellar transport 81 [Source:MGI Symbol;Acc:MGI:1098597] purinergic receptor P2X, ligand-gated ion channel, 2 [Source:MGI Symbol;Acc:MGI:2665170] testis derived transcript [Source:MGI Symbol;Acc:MGI:105081]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

forkhead box P2 [Source:MGI Symbol;Acc:MGI:2148705] LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [Source:MGI Symbol;Acc:MGI:1095413] PHD finger protein 14 [Source:MGI Symbol;Acc:MGI:1923539] Ndufa4, mitochondrial complex associated [Source:MGI Symbol;Acc:MGI:107686] predicted pseudogene 5578 [Source:MGI Symbol;Acc:MGI:3645010] glucocorticoid induced transcript 1 [Source:MGI Symbol;Acc:MGI:2179717] solute carrier family 46, member 3 [Source:MGI Symbol;Acc:MGI:1918956] heat shock 105kDa/110kDa protein 1 [Source:MGI Symbol;Acc:MGI:105053] WD40 repeat domain 95 [Source:MGI Symbol;Acc:MGI:1923042] collagen, type I, alpha 2 [Source:MGI Symbol;Acc:MGI:88468] protection of telomeres 1A [Source:MGI Symbol;Acc:MGI:2141503] Eph receptor B4 [Source:MGI Symbol;Acc:MGI:104757] transferrin receptor 2 [Source:MGI Symbol;Acc:MGI:1354956] procollagen C-endopeptidase enhancer protein [Source:MGI Symbol;Acc:MGI:105099] [Source:MGI Symbol;Acc:MGI:1350929] 3 [Source:MGI Symbol;Acc:MGI:106686] SCO-spondin [Source:MGI Symbol;Acc:MGI:2674311] hect domain and RLD 6 [Source:MGI Symbol;Acc:MGI:1914388] glycoprotein (transmembrane) nmb [Source:MGI Symbol;Acc:MGI:1934765] solute carrier family 37 (glycerol-3-phosphate transporter), member 3 [Source:MGI Symbol;Acc:MGI:1919394] glutamine fructose-6-phosphate transaminase 1 [Source:MGI Symbol;Acc:MGI:95698] NFU1 iron- cluster scaffold [Source:MGI Symbol;Acc:MGI:1913290] gastrokine 3 [Source:MGI Symbol;Acc:MGI:1916138] cell adhesion molecule L1-like [Source:MGI Symbol;Acc:MGI:1098266] Sec61 alpha 1 subunit (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1858417] plexin A1 [Source:MGI Symbol;Acc:MGI:107685] coiled-coil-helix-coiled-coil-helix domain containing 6 [Source:MGI Symbol;Acc:MGI:1913348] aldehyde dehydrogenase 1 family, member L1 [Source:MGI Symbol;Acc:MGI:1340024] basic helix-loop-helix family, member e40 [Source:MGI Symbol;Acc:MGI:1097714] ER degradation enhancer, mannosidase alpha-like 1 [Source:MGI Symbol;Acc:MGI:2180139] RasGEF domain family, member 1A [Source:MGI Symbol;Acc:MGI:1917977] killer cell lectin-like receptor subfamily K, member 1 [Source:MGI Symbol;Acc:MGI:1196250] killer cell lectin-like receptor subfamily B member 1F [Source:MGI Symbol;Acc:MGI:2442965] killer cell lectin-like receptor, subfamily D, member 1 [Source:MGI Symbol;Acc:MGI:1196275] killer cell lectin-like receptor subfamily C, member 1 [Source:MGI Symbol;Acc:MGI:1336161] wingless-type MMTV integration site family, member 5B [Source:MGI Symbol;Acc:MGI:98959] killer cell lectin-like receptor, subfamily A, member 5 [Source:MGI Symbol;Acc:MGI:101903] killer cell lectin-like receptor subfamily A, member 13, pseudogene [Source:MGI Symbol;Acc:MGI:1321090] mago homolog B, junction complex core component [Source:MGI Symbol;Acc:MGI:1913691] potassium inwardly-rectifying channel, subfamily J, member 8 [Source:MGI Symbol;Acc:MGI:1100508] ATP-binding cassette, sub-family C (CFTR/MRP), member 9 [Source:MGI Symbol;Acc:MGI:1352630] basic helix-loop-helix family, member e41 [Source:MGI Symbol;Acc:MGI:1930704] Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 [Source:MGI Symbol;Acc:MGI:1918573] branched chain aminotransferase 1, cytosolic [Source:MGI Symbol;Acc:MGI:104861] ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 [Source:MGI Symbol;Acc:MGI:106011] inositol 1,4,5-triphosphate receptor 2 [Source:MGI Symbol;Acc:MGI:99418] ATPase, Ca++ transporting, plasma membrane 2 [Source:MGI Symbol;Acc:MGI:105368] transmembrane and tetratricopeptide repeat containing 1 [Source:MGI Symbol;Acc:MGI:3039590] solute carrier family 6 (neurotransmitter transporter, GABA), member 1 [Source:MGI Symbol;Acc:MGI:95627] DENN/MADD domain containing 5B [Source:MGI Symbol;Acc:MGI:2444273] killer cell lectin-like receptor subfamily B member 1C [Source:MGI Symbol;Acc:MGI:107538]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

PILR alpha associated neural protein [Source:MGI Symbol;Acc:MGI:2441908] CD27 antigen [Source:MGI Symbol;Acc:MGI:88326] killer cell lectin-like receptor subfamily B member 1A [Source:MGI Symbol;Acc:MGI:107540] C-type lectin domain family 2, member i [Source:MGI Symbol;Acc:MGI:2136650] dystrophia myotonica-protein kinase [Source:MGI Symbol;Acc:MGI:94906] processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1913411] leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 [Source:MGI Symbol;Acc:MGI cysteine and glycine-rich protein 3 [Source:MGI Symbol;Acc:MGI:1330824] rhophilin, Rho GTPase binding protein 2 [Source:MGI Symbol;Acc:MGI:1289234] protein arginine N-methyltransferase 3 [Source:MGI Symbol;Acc:MGI:1919224] amyloid beta (A4) precursor protein-binding, family A, member 2 [Source:MGI Symbol;Acc:MGI:1261791] HD domain containing 3 [Source:MGI Symbol;Acc:MGI:1915945] sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semap tetratricopeptide repeat domain 23 [Source:MGI Symbol;Acc:MGI:1914259] milk fat globule-EGF factor 8 protein [Source:MGI Symbol;Acc:MGI:102768] synaptotagmin-like 2 [Source:MGI Symbol;Acc:MGI:1933366] SH3-domain GRB2-like 3 [Source:MGI Symbol;Acc:MGI:700011] RAB30, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:1923235] ADP-ribosyltransferase 2b [Source:MGI Symbol;Acc:MGI:107545] cytochrome P450, family 2, subfamily r, polypeptide 1 [Source:MGI Symbol;Acc:MGI:2449771] phosphodiesterase 3B, cGMP-inhibited [Source:MGI Symbol;Acc:MGI:1333863] FCH and double SH3 domains 2 [Source:MGI Symbol;Acc:MGI:2448475] mitochondrial ribosomal protein L48 [Source:MGI Symbol;Acc:MGI:1289321] myosin, heavy polypeptide 14 [Source:MGI Symbol;Acc:MGI:1919210] NSE1 homolog, SMC5-SMC6 complex component [Source:MGI Symbol;Acc:MGI:1914961] [Source:MGI Symbol;Acc:MGI:96609] dickkopf-like 1 [Source:MGI Symbol;Acc:MGI:1354963] PYD and CARD domain containing [Source:MGI Symbol;Acc:MGI:1931465] hydroxysteroid (17-beta) dehydrogenase 14 [Source:MGI Symbol;Acc:MGI:1913315] fibroblast growth factor 21 [Source:MGI Symbol;Acc:MGI:1861377] [Source:MGI Symbol;Acc:MGI:96606] fibroblast growth factor 3 [Source:MGI Symbol;Acc:MGI:95517] glypican 4 [Source:MGI Symbol;Acc:MGI:104902] coagulation factor IX [Source:MGI Symbol;Acc:MGI:88384] mcf.2 transforming sequence [Source:MGI Symbol;Acc:MGI:96932] RAB39B, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:1915040] NADPH oxidase 1 [Source:MGI Symbol;Acc:MGI:2450016] X-linked Kx blood group related, X-linked [Source:MGI Symbol;Acc:MGI:3584011] solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 [Source:MGI Symbol;Acc:MGI:110 biglycan [Source:MGI Symbol;Acc:MGI:88158] L1 cell adhesion molecule [Source:MGI Symbol;Acc:MGI:96721] zinc finger, CCHC domain containing 18 [Source:MGI Symbol;Acc:MGI:1914245] TSC22 domain family, member 3 [Source:MGI Symbol;Acc:MGI:1196284] ATPase, class VI, type 11A [Source:MGI Symbol;Acc:MGI:1354735] mcf.2 transforming sequence-like [Source:MGI Symbol;Acc:MGI:103263] coagulation factor X [Source:MGI Symbol;Acc:MGI:103107] ADP-ribosylhydrolase like 1 [Source:MGI Symbol;Acc:MGI:2442168] myomesin 2 [Source:MGI Symbol;Acc:MGI:1328358] angiopoietin 2 [Source:MGI Symbol;Acc:MGI:1202890] 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon) [Source:MGI Sym adhesion G protein-coupled receptor A2 [Source:MGI Symbol;Acc:MGI:1925810]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

RAB11 family interacting protein 1 (class I) [Source:MGI Symbol;Acc:MGI:1923017] gametogenetin [Source:MGI Symbol;Acc:MGI:2181461] collagen, type IV, alpha 1 [Source:MGI Symbol;Acc:MGI:88454] collagen, type IV, alpha 2 [Source:MGI Symbol;Acc:MGI:88455] glycoprotein m6a [Source:MGI Symbol;Acc:MGI:107671] ankyrin 1, erythroid [Source:MGI Symbol;Acc:MGI:88024] a disintegrin and metallopeptidase domain 5 [Source:MGI Symbol;Acc:MGI:104730] slit guidance ligand 2 [Source:MGI Symbol;Acc:MGI:1315205] phospholipid phosphatase 5 [Source:MGI Symbol;Acc:MGI:1919160] RNA binding protein gene with multiple splicing [Source:MGI Symbol;Acc:MGI:1334446] platelet-derived growth factor receptor-like [Source:MGI Symbol;Acc:MGI:1916047] vacuolar protein sorting 37A [Source:MGI Symbol;Acc:MGI:1261835] PDZ and LIM domain 3 [Source:MGI Symbol;Acc:MGI:1859274] thymoma viral proto-oncogene 1 interacting protein [Source:MGI Symbol;Acc:MGI:3693832] eukaryotic translation initiation factor 2 alpha kinase 3 [Source:MGI Symbol;Acc:MGI:1341830] cadherin 11 [Source:MGI Symbol;Acc:MGI:99217] origin recognition complex, subunit 6 [Source:MGI Symbol;Acc:MGI:1929285] myosin light chain kinase 3 [Source:MGI Symbol;Acc:MGI:2443063] interleukin 15 [Source:MGI Symbol;Acc:MGI:103014] colorectal neoplasia differentially expressed (non-protein coding) [Source:MGI Symbol;Acc:MGI:1918546] centromere protein N [Source:MGI Symbol;Acc:MGI:1919405] metallothionein 2 [Source:MGI Symbol;Acc:MGI:97172] metallothionein 1 [Source:MGI Symbol;Acc:MGI:97171] nudix (nucleoside diphosphate linked moiety X)-type motif 7 [Source:MGI Symbol;Acc:MGI:1914778] homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 [Source:MGI cytokine induced apoptosis inhibitor 1 [Source:MGI Symbol;Acc:MGI:1922083] dynein regulatory complex subunit 7 [Source:MGI Symbol;Acc:MGI:2685616] kinesin family member C3 [Source:MGI Symbol;Acc:MGI:109202] cyclic nucleotide gated channel beta 1 [Source:MGI Symbol;Acc:MGI:2664102] UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 [Source:MGI Symbol;Acc:MGI:2152535] RIKEN cDNA 6430548M08 gene [Source:MGI Symbol;Acc:MGI:2443793] RAB3A, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:97843] LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated [Source:MGI Symbol;Acc:MGI:1354692 cartilage oligomeric matrix protein [Source:MGI Symbol;Acc:MGI:88469] nucleoside-triphosphatase, cancer-related [Source:MGI Symbol;Acc:MGI:1913816] pre B cell leukemia homeobox 4 [Source:MGI Symbol;Acc:MGI:1931321] lysophosphatidic acid receptor 2 [Source:MGI Symbol;Acc:MGI:1858422] cadherin 5 [Source:MGI Symbol;Acc:MGI:105057] carboxylesterase 2G [Source:MGI Symbol;Acc:MGI:1919611] IZUMO1 receptor, JUNO [Source:MGI Symbol;Acc:MGI:1929185] breast cancer anti-estrogen resistance 1 [Source:MGI Symbol;Acc:MGI:108091] cytotoxic and regulatory T cell molecule [Source:MGI Symbol;Acc:MGI:1859822] junctional cadherin complex regulator [Source:MGI Symbol;Acc:MGI:1918239] RNA 2 [Source:MGI Symbol;Acc:MGI:1888981] E26 avian leukemia oncogene 1, 5' domain [Source:MGI Symbol;Acc:MGI:95455] toll-interleukin 1 receptor (TIR) domain-containing adaptor protein [Source:MGI Symbol;Acc:MGI:2152213] signal recognition particle receptor ('docking protein') [Source:MGI Symbol;Acc:MGI:1914648] POU domain, class 2, associating factor 1 [Source:MGI Symbol;Acc:MGI:105086] cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:1889272] interleukin 10 receptor, alpha [Source:MGI Symbol;Acc:MGI:96538] CD3 antigen, epsilon polypeptide [Source:MGI Symbol;Acc:MGI:88332]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

CD3 antigen, delta polypeptide [Source:MGI Symbol;Acc:MGI:88331] hypoxia up-regulated 1 [Source:MGI Symbol;Acc:MGI:108030] C2 calcium-dependent domain containing 2-like [Source:MGI Symbol;Acc:MGI:1919014] ATP binding cassette subfamily G member 4 [Source:MGI Symbol;Acc:MGI:1890594] Yip1 domain family, member 2 [Source:MGI Symbol;Acc:MGI:1922016] low density lipoprotein receptor [Source:MGI Symbol;Acc:MGI:96765] , hepatic [Source:MGI Symbol;Acc:MGI:96216] cyclin B2 [Source:MGI Symbol;Acc:MGI:88311] meiosis-specific nuclear structural protein 1 [Source:MGI Symbol;Acc:MGI:107933] retinitis pigmentosa 9 (human) [Source:MGI Symbol;Acc:MGI:2157166] progestin and adipoQ receptor family member V [Source:MGI Symbol;Acc:MGI:1921340] cytochrome P450, family 11, subfamily a, polypeptide 1 [Source:MGI Symbol;Acc:MGI:88582] collagen, type XII, alpha 1 [Source:MGI Symbol;Acc:MGI:88448] neuroplastin [Source:MGI Symbol;Acc:MGI:108077] neogenin [Source:MGI Symbol;Acc:MGI:1097159] leucine rich repeat containing 1 [Source:MGI Symbol;Acc:MGI:2442313] death-associated protein kinase 2 [Source:MGI Symbol;Acc:MGI:1341297] RAS p21 protein activator 2 [Source:MGI Symbol;Acc:MGI:2149960] zinc finger protein 949 [Source:MGI Symbol;Acc:MGI:1918890] CKLF-like MARVEL transmembrane domain containing 7 [Source:MGI Symbol;Acc:MGI:2447166] [Source:MGI Symbol;Acc:MGI:1201683] nicotinamide nucleotide adenylyltransferase 3 [Source:MGI Symbol;Acc:MGI:1921330] parathyroid hormone 1 receptor [Source:MGI Symbol;Acc:MGI:97801] tribbles pseudokinase 1 [Source:MGI Symbol;Acc:MGI:2443397] cyclic AMP-regulated phosphoprotein, 21 [Source:MGI Symbol;Acc:MGI:107562] receptor-like tyrosine kinase [Source:MGI Symbol;Acc:MGI:101766] RAB6B, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:107283] ubiquitin-like modifier activating enzyme 5 [Source:MGI Symbol;Acc:MGI:1913913] acid phosphatase, prostate [Source:MGI Symbol;Acc:MGI:1928480] copine IV [Source:MGI Symbol;Acc:MGI:1921270] collagen, type VI, alpha 4 [Source:MGI Symbol;Acc:MGI:1915803] mesencephalic astrocyte-derived neurotrophic factor [Source:MGI Symbol;Acc:MGI:1922090] protein kinase, cAMP dependent regulatory, type II alpha [Source:MGI Symbol;Acc:MGI:108025] thrombospondin, type I, domain containing 7A [Source:MGI Symbol;Acc:MGI:2685683] collagen beta(1-O)galactosyltransferase 2 [Source:MGI Symbol;Acc:MGI:2138232] cAMP responsive element binding protein-like 2 [Source:MGI Symbol;Acc:MGI:1889385] RIKEN cDNA 1700025G04 gene [Source:MGI Symbol;Acc:MGI:1916649] paraoxonase 2 [Source:MGI Symbol;Acc:MGI:106687] KN motif and ankyrin repeat domains 1 [Source:MGI Symbol;Acc:MGI:2147707] MyoD family inhibitor [Source:MGI Symbol;Acc:MGI:107687] somatomedin B and thrombospondin, type 1 domain containing [Source:MGI Symbol;Acc:MGI:2684952] inositol polyphosphate phosphatase-like 1 [Source:MGI Symbol;Acc:MGI:1333787] proline rich 5 like [Source:MGI Symbol;Acc:MGI:1919696] alpha-kinase 2 [Source:MGI Symbol;Acc:MGI:2449492] UDP galactosyltransferase 8A [Source:MGI Symbol;Acc:MGI:109522] recombination activating gene 2 [Source:MGI Symbol;Acc:MGI:97849] acyl-CoA synthetase long-chain family member 3 [Source:MGI Symbol;Acc:MGI:1921455] predicted pseudogene 6685 [Source:MGI Symbol;Acc:MGI:3704119] regulating synaptic membrane exocytosis 3 [Source:MGI Symbol;Acc:MGI:2443331] adhesion G protein-coupled receptor E4 [Source:MGI Symbol;Acc:MGI:1196464] heat shock protein 70 family, member 13 [Source:MGI Symbol;Acc:MGI:1309463]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

FK506 binding protein 1a [Source:MGI Symbol;Acc:MGI:95541] chondroitin polymerizing factor [Source:MGI Symbol;Acc:MGI:106576] killer cell lectin-like receptor subfamily A, member 9 [Source:MGI Symbol;Acc:MGI:1321153] killer cell lectin-like receptor subfamily C, member 3 [Source:MGI Symbol;Acc:MGI:1929720] LIM domain only 7 [Source:MGI Symbol;Acc:MGI:1353586] growth arrest specific 7 [Source:MGI Symbol;Acc:MGI:1202388] CDC14 cell division cycle 14B [Source:MGI Symbol;Acc:MGI:2441808] solute carrier family 22 (organic anion/cation transporter), member 15 [Source:MGI Symbol;Acc:MGI:3607704] monoglyceride lipase [Source:MGI Symbol;Acc:MGI:1346042] kelch repeat and BTB (POZ) domain containing 12 [Source:MGI Symbol;Acc:MGI:1918481] solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 [Source:MGI Sym heat shock transcription factor 4 [Source:MGI Symbol;Acc:MGI:1347058] protein tyrosine phosphatase, receptor type, M [Source:MGI Symbol;Acc:MGI:102694] protein tyrosine phosphatase, receptor type, F [Source:MGI Symbol;Acc:MGI:102695] tenascin XB [Source:MGI Symbol;Acc:MGI:1932137] carbohydrate sulfotransferase 2 [Source:MGI Symbol;Acc:MGI:1891160] receptor transporter protein 4 [Source:MGI Symbol;Acc:MGI:1915025] palmdelphin [Source:MGI Symbol;Acc:MGI:2148896] amylo-1,6-glucosidase, 4-alpha-glucanotransferase [Source:MGI Symbol;Acc:MGI:1924809] cytokine receptor-like factor 2 [Source:MGI Symbol;Acc:MGI:1889506] crystallin zeta like 2 [Source:MGI Symbol;Acc:MGI:2448516] iduronidase, alpha-L [Source:MGI Symbol;Acc:MGI:96418] diphthamide biosynthesis 5 [Source:MGI Symbol;Acc:MGI:1916990] mitogen-activated protein kinase kinase kinase 13 [Source:MGI Symbol;Acc:MGI:2444243] N-acetyltransferase 8 (GCN5-related) family member 2 [Source:MGI Symbol;Acc:MGI:2136446] dysferlin [Source:MGI Symbol;Acc:MGI:1349385] beta 2 [Source:MGI Symbol;Acc:MGI:96942] dynein, axonemal, heavy chain 8 [Source:MGI Symbol;Acc:MGI:107714] RNA binding motif protein 46 [Source:MGI Symbol;Acc:MGI:3645057] CD226 antigen [Source:MGI Symbol;Acc:MGI:3039602] FERM, RhoGEF and pleckstrin domain protein 2 [Source:MGI Symbol;Acc:MGI:2385126] protein-tyrosine sulfotransferase 1 [Source:MGI Symbol;Acc:MGI:1298231] interferon regulatory factor 2 binding protein-like [Source:MGI Symbol;Acc:MGI:2442463] ring finger protein 43 [Source:MGI Symbol;Acc:MGI:2442609] LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated [Source:MGI Symbol;Acc:MGI:1914928 BRCA1 interacting protein C-terminal helicase 1 [Source:MGI Symbol;Acc:MGI:2442836] receptor (calcitonin) activity modifying protein 1 [Source:MGI Symbol;Acc:MGI:1858418] copine II [Source:MGI Symbol;Acc:MGI:2387578] tubby like protein 4 [Source:MGI Symbol;Acc:MGI:1916092] glycine cleavage system protein H (aminomethyl carrier) [Source:MGI Symbol;Acc:MGI:1915383] sine oculis-related homeobox 4 [Source:MGI Symbol;Acc:MGI:106034] CASK-interacting protein 2 [Source:MGI Symbol;Acc:MGI:2157062] zinc finger, FYVE domain containing 9 [Source:MGI Symbol;Acc:MGI:2652838] dishevelled associated activator of morphogenesis 1 [Source:MGI Symbol;Acc:MGI:1914596] HID1 domain containing [Source:MGI Symbol;Acc:MGI:2445087] RIKEN cDNA 8430429K09 gene [Source:MGI Symbol;Acc:MGI:1918773] solute carrier family 41, member 2 [Source:MGI Symbol;Acc:MGI:2442940] lymphocyte antigen 6 complex, locus D [Source:MGI Symbol;Acc:MGI:96881] integrin alpha 2b [Source:MGI Symbol;Acc:MGI:96601] thymine DNA glycosylase [Source:MGI Symbol;Acc:MGI:108247] ribonucleic acid binding protein S1 [Source:MGI Symbol;Acc:MGI:97960]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F [Source:MGI Symbol Fraser extracellular matrix complex subunit 1 [Source:MGI Symbol;Acc:MGI:2385368] granulin [Source:MGI Symbol;Acc:MGI:95832] diacylglycerol kinase, eta [Source:MGI Symbol;Acc:MGI:2444188] cDNA sequence BC030867 [Source:MGI Symbol;Acc:MGI:2387601] CD207 antigen [Source:MGI Symbol;Acc:MGI:2180021] coiled-coil domain containing 122 [Source:MGI Symbol;Acc:MGI:1918358] copine VII [Source:MGI Symbol;Acc:MGI:2142747] thymocyte expressed, positive selection associated 1 [Source:MGI Symbol;Acc:MGI:1914846] family with sequence similarity 214, member A [Source:MGI Symbol;Acc:MGI:2387648] thromboxane A2 receptor [Source:MGI Symbol;Acc:MGI:98496] filamin A interacting protein 1 [Source:MGI Symbol;Acc:MGI:1917848] 24-dehydrocholesterol reductase [Source:MGI Symbol;Acc:MGI:1922004] ADP-ribosylation factor-like 4D [Source:MGI Symbol;Acc:MGI:1933155] CCAAT/enhancer binding protein (C/EBP), alpha [Source:MGI Symbol;Acc:MGI:99480] prostate androgen-regulated mucin-like protein 1 [Source:MGI Symbol;Acc:MGI:2443349] chemokine (C-C motif) ligand 5 [Source:MGI Symbol;Acc:MGI:98262] eva-1 homolog A (C. elegans) [Source:MGI Symbol;Acc:MGI:2385247] egl-9 family hypoxia-inducible factor 3 [Source:MGI Symbol;Acc:MGI:1932288] WD repeat domain 78 [Source:MGI Symbol;Acc:MGI:2385328] pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 [Source:MGI Symbol;Acc:MGI coiled-coil domain containing 186 [Source:MGI Symbol;Acc:MGI:2445022] family with sequence similarity 124, member A [Source:MGI Symbol;Acc:MGI:3645930] schlafen 8 [Source:MGI Symbol;Acc:MGI:2672859] heparanase [Source:MGI Symbol;Acc:MGI:1343124] adrenergic receptor, beta 1 [Source:MGI Symbol;Acc:MGI:87937] midline 1 [Source:MGI Symbol;Acc:MGI:1100537] PDZ domain containing RING finger 3 [Source:MGI Symbol;Acc:MGI:1933157] transmembrane protein 98 [Source:MGI Symbol;Acc:MGI:1923457] ATP-binding cassette, sub-family A (ABC1), member 17 [Source:MGI Symbol;Acc:MGI:3625331] chemokine (C-C motif) receptor 3 [Source:MGI Symbol;Acc:MGI:104616] solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21 [Source:MGI Symbol;Acc:MGI:2445 netrin G2 [Source:MGI Symbol;Acc:MGI:2159341] potassium voltage-gated channel, subfamily H (eag-related), member 8 [Source:MGI Symbol;Acc:MGI:2445160] mucin 20 [Source:MGI Symbol;Acc:MGI:2385039] adipogenesis associated Mth938 domain containing [Source:MGI Symbol;Acc:MGI:1913523] calcyphosphine 2 [Source:MGI Symbol;Acc:MGI:2441980] asparagine-linked glycosylation 8 (alpha-1,3-glucosyltransferase) [Source:MGI Symbol;Acc:MGI:2141959] Bardet-Biedl syndrome 10 (human) [Source:MGI Symbol;Acc:MGI:1919019] [Source:MGI Symbol;Acc:MGI:1914059] phospholipid phosphatase related 3 [Source:MGI Symbol;Acc:MGI:2388640] keratin 222 [Source:MGI Symbol;Acc:MGI:2442728] mitotic spindle positioning [Source:MGI Symbol;Acc:MGI:1926156] PRKC, apoptosis, WT1, regulator [Source:MGI Symbol;Acc:MGI:2149961] tetratricopeptide repeat domain 38 [Source:MGI Symbol;Acc:MGI:2146198] acyl-CoA synthetase short-chain family member 3 [Source:MGI Symbol;Acc:MGI:2685720] dedicator of cytokinesis 4 [Source:MGI Symbol;Acc:MGI:1918006] apurinic/apyrimidinic endonuclease 1 [Source:MGI Symbol;Acc:MGI:88042] sigma non-opioid 1 [Source:MGI Symbol;Acc:MGI:1195268] histone cluster 1, H1c [Source:MGI Symbol;Acc:MGI:1931526] suppressor APC domain containing 1 [Source:MGI Symbol;Acc:MGI:2388100]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

family with sequence similarity 69, member B [Source:MGI Symbol;Acc:MGI:1927576] potassium channel tetramerisation domain containing 1 [Source:MGI Symbol;Acc:MGI:1918269] MACRO domain containing 1 [Source:MGI Symbol;Acc:MGI:2147583] leucine rich repeat protein 3, neuronal [Source:MGI Symbol;Acc:MGI:106036] histocompatibility 2, class II antigen E alpha, pseudogene [Source:MGI Symbol;Acc:MGI:95900] solute carrier family 18 (vesicular monoamine), member 1 [Source:MGI Symbol;Acc:MGI:106684] purinergic receptor P2Y, G-protein coupled, 14 [Source:MGI Symbol;Acc:MGI:2155705] Sec24 related gene family, member A (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1924621] glucose phosphate isomerase 1 [Source:MGI Symbol;Acc:MGI:95797] transmembrane protein 255A [Source:MGI Symbol;Acc:MGI:3045722] caspase recruitment domain family, member 11 [Source:MGI Symbol;Acc:MGI:1916978] fibroblast growth factor 1 [Source:MGI Symbol;Acc:MGI:95515] fucosyltransferase 7 [Source:MGI Symbol;Acc:MGI:107692] enhancer trap locus 4 [Source:MGI Symbol;Acc:MGI:95454] myelin-associated glycoprotein [Source:MGI Symbol;Acc:MGI:96912] nudix (nucleoside diphosphate linked moiety X)-type motif 1 [Source:MGI Symbol;Acc:MGI:109280] mannosidase, alpha, class 1B, member 1 [Source:MGI Symbol;Acc:MGI:2684954] RNA binding motif protein 42 [Source:MGI Symbol;Acc:MGI:1915285] CUE domain containing 2 [Source:MGI Symbol;Acc:MGI:1914366] amidohydrolase domain containing 2 [Source:MGI Symbol;Acc:MGI:2443978] complement component 1, q subcomponent, alpha polypeptide [Source:MGI Symbol;Acc:MGI:88223] complement component 1, q subcomponent, C chain [Source:MGI Symbol;Acc:MGI:88225] complement component 1, q subcomponent, beta polypeptide [Source:MGI Symbol;Acc:MGI:88224] ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 [Source:MGI Symbol;Acc:MGI:2684986] tetraspanin 15 [Source:MGI Symbol;Acc:MGI:1917673] chloride channel accessory 3B [Source:MGI Symbol;Acc:MGI:2181989] inhibin beta-B [Source:MGI Symbol;Acc:MGI:96571] tripartite motif-containing 58 [Source:MGI Symbol;Acc:MGI:2684862] grainyhead like transcription factor 3 [Source:MGI Symbol;Acc:MGI:2655333] perforin 1 (pore forming protein) [Source:MGI Symbol;Acc:MGI:97551] motile sperm domain containing 3 [Source:MGI Symbol;Acc:MGI:1916179] zinc finger, FYVE domain containing 28 [Source:MGI Symbol;Acc:MGI:2684992] fibroblast growth factor 2 [Source:MGI Symbol;Acc:MGI:95516] double zinc ribbon and ankyrin repeat domains 1 [Source:MGI Symbol;Acc:MGI:2139080] polypeptide N-acetylgalactosaminyltransferase 6 [Source:MGI Symbol;Acc:MGI:1891640] mannosidase, alpha, class 1C, member 1 [Source:MGI Symbol;Acc:MGI:2446214] nephroblastoma overexpressed gene [Source:MGI Symbol;Acc:MGI:109185] ectonucleotide pyrophosphatase/phosphodiesterase 1 [Source:MGI Symbol;Acc:MGI:97370] regulating synaptic membrane exocytosis 2 [Source:MGI Symbol;Acc:MGI:2152972] mucin 3, intestinal [Source:MGI Symbol;Acc:MGI:1203527] serine (or cysteine) peptidase inhibitor, clade E, member 1 [Source:MGI Symbol;Acc:MGI:97608] integrator complex subunit 7 [Source:MGI Symbol;Acc:MGI:1924315] zinc finger, matrin type 4 [Source:MGI Symbol;Acc:MGI:2443497] calcium and integrin binding family member 2 [Source:MGI Symbol;Acc:MGI:1929293] vasohibin 2 [Source:MGI Symbol;Acc:MGI:2444826] WD repeat and HMG-box DNA binding protein 1 [Source:MGI Symbol;Acc:MGI:2443514] GTP cyclohydrolase 1 [Source:MGI Symbol;Acc:MGI:95675] nuclear receptor subfamily 0, group B, member 2 [Source:MGI Symbol;Acc:MGI:1346344] clathrin binding box of aftiphilin containing 1 [Source:MGI Symbol;Acc:MGI:2443738] keratinocyte differentiation factor 1 [Source:MGI Symbol;Acc:MGI:1916323] potassium large conductance calcium-activated channel, subfamily M, beta member 2 [Source:MGI Symbol;Acc:

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

atonal bHLH transcription factor 8 [Source:MGI Symbol;Acc:MGI:1918343] histocompatibility 2, class II, locus DMa [Source:MGI Symbol;Acc:MGI:95921] extended synaptotagmin-like protein 3 [Source:MGI Symbol;Acc:MGI:1098699] armadillo repeat containing 3 [Source:MGI Symbol;Acc:MGI:1918132] sperm associated antigen 6 [Source:MGI Symbol;Acc:MGI:3040687] associated protein 2 [Source:MGI Symbol;Acc:MGI:1931797] LIM and calponin homology domains 1 [Source:MGI Symbol;Acc:MGI:1924819] protein phosphatase 1, regulatory subunit 16B [Source:MGI Symbol;Acc:MGI:2151841] transglutaminase 2, C polypeptide [Source:MGI Symbol;Acc:MGI:98731] signal-regulatory protein alpha [Source:MGI Symbol;Acc:MGI:108563] B cell scaffold protein with ankyrin repeats 1 [Source:MGI Symbol;Acc:MGI:2442120] SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 [Source:MGI coiled-coil domain containing 92 [Source:MGI Symbol;Acc:MGI:106485] RecQ mediated genome instability 2 [Source:MGI Symbol;Acc:MGI:2685383] solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 [Source:MGI Symbol;Acc:MGI: coiled-coil domain containing 138 [Source:MGI Symbol;Acc:MGI:1923388] dynein, axonemal, heavy chain 10 [Source:MGI Symbol;Acc:MGI:1860299] Rap guanine nucleotide exchange factor (GEF)-like 1 [Source:MGI Symbol;Acc:MGI:3611446] MINDY lysine 48 deubiquitinase 4 [Source:MGI Symbol;Acc:MGI:3583959] suppressor of cytokine signaling 1 [Source:MGI Symbol;Acc:MGI:1354910] nucleotide-binding oligomerization domain containing 1 [Source:MGI Symbol;Acc:MGI:1341839] small integral membrane protein 3 [Source:MGI Symbol;Acc:MGI:1917088] FK506 binding protein 14 [Source:MGI Symbol;Acc:MGI:2387639] calcium/calmodulin-dependent protein kinase IV [Source:MGI Symbol;Acc:MGI:88258] storkhead box 2 [Source:MGI Symbol;Acc:MGI:1918319] PR domain containing 1, with ZNF domain [Source:MGI Symbol;Acc:MGI:99655] spondin 1, (f-spondin) extracellular matrix protein [Source:MGI Symbol;Acc:MGI:2385287] phosphodiesterase 4D interacting protein (myomegalin) [Source:MGI Symbol;Acc:MGI:1891434] tetratricopeptide repeat domain 39B [Source:MGI Symbol;Acc:MGI:1917113] ectonucleotide pyrophosphatase/phosphodiesterase 6 [Source:MGI Symbol;Acc:MGI:2445171] SLAM family member 7 [Source:MGI Symbol;Acc:MGI:1922595] chondroitin polymerizing factor 2 [Source:MGI Symbol;Acc:MGI:1917522] intelectin 1 (galactofuranose binding) [Source:MGI Symbol;Acc:MGI:1333831] TAP binding protein-like [Source:MGI Symbol;Acc:MGI:2384853] predicted gene 9765 [Source:MGI Symbol;Acc:MGI:3642721] microtubule associated monooxygenase, calponin and LIM domain containing 2 [Source:MGI Symbol;Acc:MGI:2 osteopetrosis associated transmembrane protein 1 [Source:MGI Symbol;Acc:MGI:2655574] sorting nexin 10 [Source:MGI Symbol;Acc:MGI:1919232] CD160 antigen [Source:MGI Symbol;Acc:MGI:1860383] ER degradation enhancer, mannosidase alpha-like 2 [Source:MGI Symbol;Acc:MGI:1915540] potassium voltage-gated channel, subfamily H (eag-related), member 2 [Source:MGI Symbol;Acc:MGI:1341722] ankyrin repeat domain 35 [Source:MGI Symbol;Acc:MGI:2442590] Purkinje cell protein 4-like 1 [Source:MGI Symbol;Acc:MGI:1913675] SET binding factor 2 [Source:MGI Symbol;Acc:MGI:1921831] transformation related protein 53 inducible nuclear protein 2 [Source:MGI Symbol;Acc:MGI:1915978] Fc receptor-like A [Source:MGI Symbol;Acc:MGI:2138647] polymerase (DNA directed), iota [Source:MGI Symbol;Acc:MGI:1347081] DENN/MADD domain containing 2A [Source:MGI Symbol;Acc:MGI:2444961] olfactomedin-like 2B [Source:MGI Symbol;Acc:MGI:2443310] regulator of G-protein signaling 4 [Source:MGI Symbol;Acc:MGI:108409] zinc finger with KRAB and SCAN domains 16 [Source:MGI Symbol;Acc:MGI:3510405]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

delta(4)-desaturase, sphingolipid 1 [Source:MGI Symbol;Acc:MGI:1097711] cathepsin S [Source:MGI Symbol;Acc:MGI:107341] cAMP responsive element binding protein 3-like 2 [Source:MGI Symbol;Acc:MGI:2442695] signal peptide, CUB domain, EGF-like 3 [Source:MGI Symbol;Acc:MGI:3045253] polycystic kidney and hepatic disease 1-like 1 [Source:MGI Symbol;Acc:MGI:2183153] SH3 and multiple ankyrin repeat domains 1 [Source:MGI Symbol;Acc:MGI:3613677] left right determination factor 1 [Source:MGI Symbol;Acc:MGI:107405] zinc finger and SCAN domain containing 2 [Source:MGI Symbol;Acc:MGI:99176] RAP1 GTPase [Source:MGI Symbol;Acc:MGI:3028623] transmembrane protein 214 [Source:MGI Symbol;Acc:MGI:1916046] insulin receptor 2 [Source:MGI Symbol;Acc:MGI:109334] consortin, connexin sorting protein [Source:MGI Symbol;Acc:MGI:2445141] suppressor of Ty 3 [Source:MGI Symbol;Acc:MGI:1923723] thioredoxin domain containing 5 [Source:MGI Symbol;Acc:MGI:2145316] bone morphogenetic protein 6 [Source:MGI Symbol;Acc:MGI:88182] ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 [S zinc finger protein 503 [Source:MGI Symbol;Acc:MGI:1353644] coagulation factor XIII, A1 subunit [Source:MGI Symbol;Acc:MGI:1921395] adhesion G protein-coupled receptor L4 [Source:MGI Symbol;Acc:MGI:2655562] recombination signal binding protein for immunoglobulin kappa J region [Source:MGI Symbol;Acc:MGI:96522] Sec24 related gene family, member D (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1916858] transforming growth factor, beta 2 [Source:MGI Symbol;Acc:MGI:98726] RIKEN cDNA 2300002M23 gene [Source:MGI Symbol;Acc:MGI:1916792] multiple EGF-like-domains 9 [Source:MGI Symbol;Acc:MGI:1918264] fibronectin type III domain containing 3B [Source:MGI Symbol;Acc:MGI:1919257] cytokine-dependent hematopoietic cell linker [Source:MGI Symbol;Acc:MGI:1351468] melanoregulin [Source:MGI Symbol;Acc:MGI:2151839] periplakin [Source:MGI Symbol;Acc:MGI:1194898] wolframin ER transmembrane glycoprotein [Source:MGI Symbol;Acc:MGI:1328355] dermatan sulfate epimerase [Source:MGI Symbol;Acc:MGI:2443455] UHRF1 (ICBP90) binding protein 1 [Source:MGI Symbol;Acc:MGI:3041238] corneodesmosin [Source:MGI Symbol;Acc:MGI:3505689] coiled-coil serine rich 1 [Source:MGI Symbol;Acc:MGI:3045354] regulator of calcineurin 2 [Source:MGI Symbol;Acc:MGI:1858219] striatin interacting protein 2 [Source:MGI Symbol;Acc:MGI:2444363] cytoplasmic polyadenylation element binding protein 3 [Source:MGI Symbol;Acc:MGI:2443075] LIM domain binding 2 [Source:MGI Symbol;Acc:MGI:894670] cytoplasmic polyadenylation element binding protein 2 [Source:MGI Symbol;Acc:MGI:2442640] X-linked Kx blood group related 5 [Source:MGI Symbol;Acc:MGI:2442327] RIKEN cDNA 4932438H23 gene [Source:MGI Symbol;Acc:MGI:1921637] solute carrier family 26, member 11 [Source:MGI Symbol;Acc:MGI:2444589] gamma-secretase activating protein [Source:MGI Symbol;Acc:MGI:2442259] coiled-coil domain containing 40 [Source:MGI Symbol;Acc:MGI:2443893] zinc finger CCCH type containing 12D [Source:MGI Symbol;Acc:MGI:3045313] chromobox 4 [Source:MGI Symbol;Acc:MGI:1195985] timeless circadian 1 [Source:MGI Symbol;Acc:MGI:1321393] dispatched RND tramsporter family member 2 [Source:MGI Symbol;Acc:MGI:2388733] neuronal growth regulator 1 [Source:MGI Symbol;Acc:MGI:2444846] BCL2 modifying factor [Source:MGI Symbol;Acc:MGI:2176433] monoamine oxidase B [Source:MGI Symbol;Acc:MGI:96916] thrombospondin 1 [Source:MGI Symbol;Acc:MGI:98737]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D [Source:MGI Symbol guanylate binding protein 2b [Source:MGI Symbol;Acc:MGI:95666] pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 [Source:MGI Sym 1-aminocyclopropane-1-carboxylate synthase (non-functional) [Source:MGI Symbol;Acc:MGI:1919717] Ndufa4, mitochondrial complex associated like 2 [Source:MGI Symbol;Acc:MGI:3039567] SH3 and cysteine rich domain 3 [Source:MGI Symbol;Acc:MGI:3606571] aristaless-like homeobox 4 [Source:MGI Symbol;Acc:MGI:108359] coiled-coil alpha-helical rod protein 1 [Source:MGI Symbol;Acc:MGI:2385321] [Source:MGI Symbol;Acc:MGI:88563] olfactory receptor 56 [Source:MGI Symbol;Acc:MGI:1333785] testis expressed 45 [Source:MGI Symbol;Acc:MGI:1923656] UFM1 specific ligase 1 [Source:MGI Symbol;Acc:MGI:1914740] G protein-coupled receptor 63 [Source:MGI Symbol;Acc:MGI:2135884] kelch-like 32 [Source:MGI Symbol;Acc:MGI:3612790] gamma-glutamyltransferase 6 [Source:MGI Symbol;Acc:MGI:1918772] latent transforming growth factor beta binding protein 4 [Source:MGI Symbol;Acc:MGI:1321395] membrane-associated ring finger (C3HC4) 9 [Source:MGI Symbol;Acc:MGI:2446144] toll-like receptor 8 [Source:MGI Symbol;Acc:MGI:2176887] RIKEN cDNA 1110051M20 gene [Source:MGI Symbol;Acc:MGI:1915079] CD79B antigen [Source:MGI Symbol;Acc:MGI:96431] pleckstrin homology domain containing, family G (with RhoGef domain) member 1 [Source:MGI Symbol;Acc:MGI 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 [Source:MGI Symbol;Acc:MGI:3039376] interleukin 17 receptor D [Source:MGI Symbol;Acc:MGI:2159727] ETS transcription factor [Source:MGI Symbol;Acc:MGI:95415] chitinase-like 3 [Source:MGI Symbol;Acc:MGI:1330860] ATP/GTP binding protein-like 2 [Source:MGI Symbol;Acc:MGI:2443254] RALBP1 associated Eps domain containing protein 2 [Source:MGI Symbol;Acc:MGI:2663511] ciliary rootlet coiled-coil, rootletin [Source:MGI Symbol;Acc:MGI:3529431] potassium voltage-gated channel, Shal-related family, member 3 [Source:MGI Symbol;Acc:MGI:1928743] chemokine (C-C motif) receptor 6 [Source:MGI Symbol;Acc:MGI:1333797] H2A histone family, member V [Source:MGI Symbol;Acc:MGI:1924855] sperm maturation 1 [Source:MGI Symbol;Acc:MGI:1921538] , group IID [Source:MGI Symbol;Acc:MGI:1341796] chromodomain helicase DNA binding protein 7 [Source:MGI Symbol;Acc:MGI:2444748] cystic fibrosis transmembrane conductance regulator [Source:MGI Symbol;Acc:MGI:88388] NK6 homeobox 2 [Source:MGI Symbol;Acc:MGI:1352738] ATPase, Na+/K+ transporting, beta 2 polypeptide [Source:MGI Symbol;Acc:MGI:88109] bradykinin receptor, beta 1 [Source:MGI Symbol;Acc:MGI:88144] Rap1 GTPase-activating protein [Source:MGI Symbol;Acc:MGI:109338] pumilio RNA-binding family member 3 [Source:MGI Symbol;Acc:MGI:106253] myocardial zonula adherens protein [Source:MGI Symbol;Acc:MGI:2142908] glycerol kinase 5 (putative) [Source:MGI Symbol;Acc:MGI:2443336] Rho GTPase activating protein 32 [Source:MGI Symbol;Acc:MGI:2450166] ribosomal protein L21 [Source:MGI Symbol;Acc:MGI:1278340] histocompatibility 2, O region beta locus [Source:MGI Symbol;Acc:MGI:95925] calmodulin regulated spectrin-associated protein family, member 2 [Source:MGI Symbol;Acc:MGI:1922434] NLR family, pyrin domain containing 5, pseudogene [Source:MGI Symbol;Acc:MGI:5010941] coronin, actin binding protein, 2B [Source:MGI Symbol;Acc:MGI:2444283] kirre like nephrin family adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:1891396] CD1d2 antigen [Source:MGI Symbol;Acc:MGI:107675] G protein-coupled receptor 155 [Source:MGI Symbol;Acc:MGI:1915776]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

translocating chain-associating membrane protein 2 [Source:MGI Symbol;Acc:MGI:1924817] RIKEN cDNA 2700046A07 gene [Source:MGI Symbol;Acc:MGI:1919803] ATP-binding cassette, sub-family A (ABC1), member 9 [Source:MGI Symbol;Acc:MGI:2386796] synaptotagmin-like 3 [Source:MGI Symbol;Acc:MGI:1933367] HAUS augmin-like complex, subunit 1 [Source:MGI Symbol;Acc:MGI:2385076] caspase recruitment domain family, member 6 [Source:MGI Symbol;Acc:MGI:3032959] oocyte secreted protein 1 [Source:MGI Symbol;Acc:MGI:2149290] interleukin 17F [Source:MGI Symbol;Acc:MGI:2676631] shisa family member 4 [Source:MGI Symbol;Acc:MGI:1924802] lectin, mannose-binding, 1 [Source:MGI Symbol;Acc:MGI:1917611] WD repeat domain, phosphoinositide interacting 1 [Source:MGI Symbol;Acc:MGI:1261864] G protein-coupled receptor 45 [Source:MGI Symbol;Acc:MGI:2135882] methionyl aminopeptidase type 1D (mitochondrial) [Source:MGI Symbol;Acc:MGI:1913809] arginyl aminopeptidase (aminopeptidase B) [Source:MGI Symbol;Acc:MGI:2384902] zinc and ring finger 3 [Source:MGI Symbol;Acc:MGI:3039616] heterogeneous nuclear ribonucleoprotein F [Source:MGI Symbol;Acc:MGI:2138741] [Source:MGI Symbol;Acc:MGI:88075] slingshot protein phosphatase 1 [Source:MGI Symbol;Acc:MGI:2686240] Ras association (RalGDS/AF-6) domain family member 4 [Source:MGI Symbol;Acc:MGI:2386853] BEN domain containing 6 [Source:MGI Symbol;Acc:MGI:2444572] chemokine-like receptor 1 [Source:MGI Symbol;Acc:MGI:109603] abhydrolase domain containing 14A [Source:MGI Symbol;Acc:MGI:1915894] transmembrane channel-like gene family 7 [Source:MGI Symbol;Acc:MGI:2443317] peptidase M20 domain containing 1 [Source:MGI Symbol;Acc:MGI:2442939] S100 calcium binding protein A14 [Source:MGI Symbol;Acc:MGI:1913416] apoptosis resistant E3 ubiquitin protein ligase 1 [Source:MGI Symbol;Acc:MGI:1915747] GRB2-related adaptor protein 2 [Source:MGI Symbol;Acc:MGI:1333842] gap junction protein, beta 5 [Source:MGI Symbol;Acc:MGI:95723] family with sequence similarity 83, member G [Source:MGI Symbol;Acc:MGI:1916890] myosin binding protein H [Source:MGI Symbol;Acc:MGI:1858196] reelin [Source:MGI Symbol;Acc:MGI:103022] dCTP pyrophosphatase 1 [Source:MGI Symbol;Acc:MGI:1913672] melanoma associated antigen (mutated) 1-like 1 [Source:MGI Symbol;Acc:MGI:2445062] lysine (K)-specific demethylase 7A [Source:MGI Symbol;Acc:MGI:2443388] alkB homolog 5, RNA demethylase [Source:MGI Symbol;Acc:MGI:2144489] mitogen-activated protein kinase kinase kinase 9 [Source:MGI Symbol;Acc:MGI:2449952] brain expressed X-linked 2 [Source:MGI Symbol;Acc:MGI:1338017] transmembrane protein 108 [Source:MGI Symbol;Acc:MGI:1932411] mucin 1, transmembrane [Source:MGI Symbol;Acc:MGI:97231] glutathione peroxidase 2 [Source:MGI Symbol;Acc:MGI:106609] neuronal regeneration related protein [Source:MGI Symbol;Acc:MGI:99444] activating motif and SAP domain containing transcriptional regulator [Source:MGI Symbol;Acc:MGI:19217 notum palmitoleoyl-protein carboxylesterase [Source:MGI Symbol;Acc:MGI:1924833] ER degradation enhancer, mannosidase alpha-like 3 [Source:MGI Symbol;Acc:MGI:1914217] loricrin [Source:MGI Symbol;Acc:MGI:96816] predicted gene 1840 [Source:MGI Symbol;Acc:MGI:3037698] zinc metallopeptidase, STE24 [Source:MGI Symbol;Acc:MGI:1890508] family with sequence similarity 129, member C [Source:MGI Symbol;Acc:MGI:3686743] interferon activated gene 209 [Source:MGI Symbol;Acc:MGI:2138243] UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1 [Source:MGI Symbol;Acc:MGI:13494 filamin A interacting protein 1-like [Source:MGI Symbol;Acc:MGI:1925999]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

olfactory receptor 1342 [Source:MGI Symbol;Acc:MGI:3031176] eukaryotic translation initiation factor 3, subunit J2 [Source:MGI Symbol;Acc:MGI:3704486] zinc finger protein 536 [Source:MGI Symbol;Acc:MGI:1926102] a disintegrin and metallopeptidase domain 30 [Source:MGI Symbol;Acc:MGI:1918328] MAM domain containing glycosylphosphatidylinositol anchor 1 [Source:MGI Symbol;Acc:MGI:1922012] UBX domain protein 10 [Source:MGI Symbol;Acc:MGI:2443123] RIKEN cDNA 0610009L18 gene [Source:MGI Symbol;Acc:MGI:1914088] phospholipase D family, member 6 [Source:MGI Symbol;Acc:MGI:2687283] transmembrane protein 221 [Source:MGI Symbol;Acc:MGI:3525074] calpain 13 [Source:MGI Symbol;Acc:MGI:2685789] ADAMTS-like 5 [Source:MGI Symbol;Acc:MGI:1913798] C-type lectin domain family 4, member a3 [Source:MGI Symbol;Acc:MGI:1920399] olfactory receptor 544 [Source:MGI Symbol;Acc:MGI:3030378] killer cell lectin-like receptor family I member 2 [Source:MGI Symbol;Acc:MGI:2443965] chemokine (C-C motif) receptor-like 2 [Source:MGI Symbol;Acc:MGI:1920904] coiled-coil domain containing 141 [Source:MGI Symbol;Acc:MGI:1919735] chemokine (C-C motif) receptor 10 [Source:MGI Symbol;Acc:MGI:1096320] otospiralin [Source:MGI Symbol;Acc:MGI:2672814] zinc finger protein 85, opposite strand [Source:MGI Symbol;Acc:MGI:1915521] HEPACAM family member 2 [Source:MGI Symbol;Acc:MGI:2141520] forkhead box O1 [Source:MGI Symbol;Acc:MGI:1890077] V-set and immunoglobulin domain containing 4 [Source:MGI Symbol;Acc:MGI:2679720] predicted gene 7887 [Source:MGI Symbol;Acc:MGI:3648251] oxysterol binding protein-like 1A [Source:MGI Symbol;Acc:MGI:1927551] cytotoxic T lymphocyte-associated protein 2 alpha [Source:MGI Symbol;Acc:MGI:88554] olfactomedin 5 [Source:MGI Symbol;Acc:MGI:2443346] crumbs family member 3 [Source:MGI Symbol;Acc:MGI:2670904] RIKEN cDNA 1700001O22 gene [Source:MGI Symbol;Acc:MGI:1923631] predicted gene 9493 [Source:MGI Symbol;Acc:MGI:3779903] terminal nucleotidyltransferase 5C [Source:MGI Symbol;Acc:MGI:1921895] ribosomal protein S2 [Source:MGI Symbol;Acc:MGI:105110] Ras interacting protein 1 [Source:MGI Symbol;Acc:MGI:1917153] acid phosphatase 1, soluble [Source:MGI Symbol;Acc:MGI:87881] small integral membrane protein 7 [Source:MGI Symbol;Acc:MGI:1914068] zinc finger protein 612 [Source:MGI Symbol;Acc:MGI:2443465] lymphocyte antigen 6 complex, locus K [Source:MGI Symbol;Acc:MGI:1923736] RIKEN cDNA 2010007H06 gene [Source:MGI Symbol;Acc:MGI:1917099] serine (or cysteine) peptidase inhibitor, clade B, member 1a [Source:MGI Symbol;Acc:MGI:1913472] predicted gene 12231 [Source:MGI Symbol;Acc:MGI:3651344] olfactory receptor 543 [Source:MGI Symbol;Acc:MGI:3030377] Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 [Source:MGI Symbol;Acc:MGI:2384307] zinc finger protein 367 [Source:MGI Symbol;Acc:MGI:2442266] tubulin, gamma 2 [Source:MGI Symbol;Acc:MGI:2144208] sphingosine-1-phosphate receptor 5 [Source:MGI Symbol;Acc:MGI:2150641] Rho guanine nucleotide exchange factor (GEF) 37 [Source:MGI Symbol;Acc:MGI:3045339] membrane associated guanylate kinase, WW and PDZ domain containing 1 [Source:MGI Symbol;Acc:MGI:12035 predicted gene 5514 [Source:MGI Symbol;Acc:MGI:3645435] MORN repeat containing 2 [Source:MGI Symbol;Acc:MGI:2674071] zinc finger protein 691 [Source:MGI Symbol;Acc:MGI:3041163] centromere protein H [Source:MGI Symbol;Acc:MGI:1349448] reticulon 4 receptor-like 1 [Source:MGI Symbol;Acc:MGI:2661375]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

insulin induced gene 1 [Source:MGI Symbol;Acc:MGI:1916289] RIKEN cDNA 6330549D23 gene [Source:MGI Symbol;Acc:MGI:2442586] transmembrane protein 88 [Source:MGI Symbol;Acc:MGI:1914270] olfactory receptor 433 [Source:MGI Symbol;Acc:MGI:3030267] chemokine (C-X-C motif) receptor 4 [Source:MGI Symbol;Acc:MGI:109563] olfactory receptor 1033 [Source:MGI Symbol;Acc:MGI:3030867] epithelial cell adhesion molecule [Source:MGI Symbol;Acc:MGI:106653] aldo-keto reductase family 1, member E1 [Source:MGI Symbol;Acc:MGI:1914758] GPRIN family member 3 [Source:MGI Symbol;Acc:MGI:1924785] G protein-coupled receptor 150 [Source:MGI Symbol;Acc:MGI:2441872] galactosidase, beta 1 [Source:MGI Symbol;Acc:MGI:88151] mitochondrial tumor suppressor 1 [Source:MGI Symbol;Acc:MGI:2142572] phosphotyrosine interaction domain containing 1 [Source:MGI Symbol;Acc:MGI:2138391] PQ loop repeat containing [Source:MGI Symbol;Acc:MGI:2444067] predicted gene, 21411 [Source:MGI Symbol;Acc:MGI:5434766] solute carrier family 16 (monocarboxylic acid transporters), member 5 [Source:MGI Symbol;Acc:MGI:2443515] interferon induced transmembrane protein 10 [Source:MGI Symbol;Acc:MGI:2444776] TGFB-induced factor homeobox 2, pseudogene 2 [Source:MGI Symbol;Acc:MGI:3805950] GTPase, very large interferon inducible 1 [Source:MGI Symbol;Acc:MGI:1921808] RIKEN cDNA 4933440M02 gene [Source:MGI Symbol;Acc:MGI:1918458] C-type lectin domain family 14, member a [Source:MGI Symbol;Acc:MGI:1914114] StAR-related lipid transfer (START) domain containing 5 [Source:MGI Symbol;Acc:MGI:2156765] suprabasin [Source:MGI Symbol;Acc:MGI:2446326] fucosyltransferase 10 [Source:MGI Symbol;Acc:MGI:2384748] protocadherin beta 20 [Source:MGI Symbol;Acc:MGI:2136758] chymosin [Source:MGI Symbol;Acc:MGI:2684977] ankyrin repeat and LEM domain containing 1 [Source:MGI Symbol;Acc:MGI:1918775] protocadherin beta 17 [Source:MGI Symbol;Acc:MGI:2136754] retinol binding protein 1, cellular [Source:MGI Symbol;Acc:MGI:97876] potassium inwardly-rectifying channel, subfamily K, member 6 [Source:MGI Symbol;Acc:MGI:1891291] brain expressed X-linked 3 [Source:MGI Symbol;Acc:MGI:1338016] calcium/calmodulin-dependent protein kinase II inhibitor 1 [Source:MGI Symbol;Acc:MGI:1913509] unc-119 lipid binding chaperone B [Source:MGI Symbol;Acc:MGI:2147162] leucine rich repeat containing 8 family, member E [Source:MGI Symbol;Acc:MGI:1919517] transmembrane protein 215 [Source:MGI Symbol;Acc:MGI:2444167] gap junction protein, beta 4 [Source:MGI Symbol;Acc:MGI:95722] polycystic kidney disease 1 like 1 [Source:MGI Symbol;Acc:MGI:2156538] predicted gene 7729 [Source:MGI Symbol;Acc:MGI:3647361] EPM2A (laforin) interacting protein 1 [Source:MGI Symbol;Acc:MGI:1925031] leucine rich repeat containing 75B [Source:MGI Symbol;Acc:MGI:2143657] cytoskeleton-associated protein 4 [Source:MGI Symbol;Acc:MGI:2444926] myc target 1 [Source:MGI Symbol;Acc:MGI:1915882] solute carrier family 26 (), member 1 [Source:MGI Symbol;Acc:MGI:2385894] olfactory receptor 432 [Source:MGI Symbol;Acc:MGI:3030266] RIKEN cDNA 1700001C19 gene [Source:MGI Symbol;Acc:MGI:1922712] gap junction protein, delta 3 [Source:MGI Symbol;Acc:MGI:2384150] ribonuclease, RNase A family, 2A (liver, eosinophil-derived neurotoxin) [Source:MGI Symbol;Acc:MGI:1890465] G protein-coupled receptor 68 [Source:MGI Symbol;Acc:MGI:2441763] delta like non-canonical Notch ligand 2 [Source:MGI Symbol;Acc:MGI:2146838] G protein-coupled receptor 141B [Source:MGI Symbol;Acc:MGI:2441809] olfactory receptor 1396 [Source:MGI Symbol;Acc:MGI:3031230]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

deleted in malignant brain tumors 1 [Source:MGI Symbol;Acc:MGI:106210] non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) [Source:MGI Symbol;Acc:MGI:2685009] fibroblast growth factor binding protein 3 [Source:MGI Symbol;Acc:MGI:1919764] RIKEN cDNA D930020B18 gene [Source:MGI Symbol;Acc:MGI:2442001] complement receptor related protein, pseudogene [Source:MGI Symbol;Acc:MGI:88514] UbiA prenyltransferase domain containing 1 [Source:MGI Symbol;Acc:MGI:1918957] leucine rich repeat containing 49 [Source:MGI Symbol;Acc:MGI:2442689] sushi, nidogen and EGF-like domains 1 [Source:MGI Symbol;Acc:MGI:3045960] alpha 1,4-galactosyltransferase [Source:MGI Symbol;Acc:MGI:3512453] somatostatin receptor 2 [Source:MGI Symbol;Acc:MGI:98328] predicted gene 4737 [Source:MGI Symbol;Acc:MGI:3643647] ectonucleoside triphosphate diphosphohydrolase 1 [Source:MGI Symbol;Acc:MGI:102805] olfactory receptor 49 [Source:MGI Symbol;Acc:MGI:1333764] adhesion molecule with Ig like domain 2 [Source:MGI Symbol;Acc:MGI:2145995] coagulation factor II (thrombin) receptor [Source:MGI Symbol;Acc:MGI:101802] GLI-Kruppel family member GLI2 [Source:MGI Symbol;Acc:MGI:95728] small integral membrane protein 5 [Source:MGI Symbol;Acc:MGI:1913778] chemokine (C-X-C motif) receptor 1 [Source:MGI Symbol;Acc:MGI:2448715] CD300E molecule [Source:MGI Symbol;Acc:MGI:2387602] junction adhesion molecule like [Source:MGI Symbol;Acc:MGI:2685484] myoferlin [Source:MGI Symbol;Acc:MGI:1919192] predicted gene 6377 [Source:MGI Symbol;Acc:MGI:3647255] cortexin 1 [Source:MGI Symbol;Acc:MGI:88566] ribosomal protein L29 [Source:MGI Symbol;Acc:MGI:99687] predicted gene 12185 [Source:MGI Symbol;Acc:MGI:3652173] neuron-derived neurotrophic factor [Source:MGI Symbol;Acc:MGI:1915419] C-type lectin domain family 4, member a1 [Source:MGI Symbol;Acc:MGI:3036291] chemokine (C-C motif) receptor 2 [Source:MGI Symbol;Acc:MGI:106185] FERM domain containing 3 [Source:MGI Symbol;Acc:MGI:2442466] cation channel sperm associated auxiliary subunit gamma 2 [Source:MGI Symbol;Acc:MGI:1923968] fucosyltransferase 4 [Source:MGI Symbol;Acc:MGI:95594] sortilin-related receptor, LDLR class A repeats-containing [Source:MGI Symbol;Acc:MGI:1202296] zymogen granule protein 16 [Source:MGI Symbol;Acc:MGI:1916286] plastin 1 (I-isoform) [Source:MGI Symbol;Acc:MGI:104809] coiled-coil domain containing 69 [Source:MGI Symbol;Acc:MGI:1196234] G protein-coupled receptor 55 [Source:MGI Symbol;Acc:MGI:2685064] protease, serine 33 [Source:MGI Symbol;Acc:MGI:2661234] TRAF-interacting protein with forkhead-associated domain, family member B [Source:MGI Symbol;Acc:MGI:2385 Rho GTPase activating protein 15 [Source:MGI Symbol;Acc:MGI:1923367] ankyrin repeat domain 55 [Source:MGI Symbol;Acc:MGI:1924568] testis development related protein [Source:MGI Symbol;Acc:MGI:1919398] serine peptidase inhibitor, Kazal type 8 [Source:MGI Symbol;Acc:MGI:1925959] G protein-coupled receptor 171 [Source:MGI Symbol;Acc:MGI:2442043] BPI fold containing family C [Source:MGI Symbol;Acc:MGI:3026884] oligodendrocytic myelin paranodal and inner loop protein [Source:MGI Symbol;Acc:MGI:2657025] stearoyl-coenzyme A desaturase 4 [Source:MGI Symbol;Acc:MGI:2670997] phospholipase A2, group IVE [Source:MGI Symbol;Acc:MGI:1919144] chemokine (C-X-C motif) receptor 3 [Source:MGI Symbol;Acc:MGI:1277207] killer cell lectin-like receptor family E member 1 [Source:MGI Symbol;Acc:MGI:2662547] DS cell adhesion molecule [Source:MGI Symbol;Acc:MGI:1196281] synaptopodin 2 [Source:MGI Symbol;Acc:MGI:2153070]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

G protein-coupled receptor 18 [Source:MGI Symbol;Acc:MGI:107859] expressed sequence C77080 [Source:MGI Symbol;Acc:MGI:2140651] solute carrier family 35, member D3 [Source:MGI Symbol;Acc:MGI:1923407] predicted gene 8394 [Source:MGI Symbol;Acc:MGI:3647964] F-box and leucine-rich repeat protein 22 [Source:MGI Symbol;Acc:MGI:1921415] RIKEN cDNA B230217C12 gene [Source:MGI Symbol;Acc:MGI:1915377] predicted gene 11868 [Source:MGI Symbol;Acc:MGI:3650507] V-set and transmembrane domain containing 4 [Source:MGI Symbol;Acc:MGI:2444633] prostaglandin E synthase [Source:MGI Symbol;Acc:MGI:1927593] piggyBac transposable element derived 5 [Source:MGI Symbol;Acc:MGI:2429955] zinc finger protein 366 [Source:MGI Symbol;Acc:MGI:2178429] purinergic receptor P2Y, G-protein coupled 10 [Source:MGI Symbol;Acc:MGI:1926076] predicted gene 42743 [Source:MGI Symbol;Acc:MGI:5662880] selenoprotein N [Source:MGI Symbol;Acc:MGI:2151208] androglobin [Source:MGI Symbol;Acc:MGI:3605549] olfactomedin-like 1 [Source:MGI Symbol;Acc:MGI:2679264] olfactory receptor 523 [Source:MGI Symbol;Acc:MGI:3030357] synaptic vesicle glycoprotein 2c [Source:MGI Symbol;Acc:MGI:1922459] phospholipase C, beta 1 [Source:MGI Symbol;Acc:MGI:97613] ring finger protein 7 [Source:MGI Symbol;Acc:MGI:1337096] free fatty acid receptor 2 [Source:MGI Symbol;Acc:MGI:2441731] pleckstrin homology domain containing, family M, member 3 [Source:MGI Symbol;Acc:MGI:2443627] sterile alpha motif domain containing 3 [Source:MGI Symbol;Acc:MGI:2685469] neurocalcin delta [Source:MGI Symbol;Acc:MGI:1196326] ubiquilin-like [Source:MGI Symbol;Acc:MGI:2685336] CD14 antigen [Source:MGI Symbol;Acc:MGI:88318] carbonyl reductase 1 [Source:MGI Symbol;Acc:MGI:88284] toll-like receptor 6 [Source:MGI Symbol;Acc:MGI:1341296] Rho guanine nucleotide exchange factor (GEF) 39 [Source:MGI Symbol;Acc:MGI:3036286] triggering receptor expressed on myeloid cells-like 4 [Source:MGI Symbol;Acc:MGI:1923239] transmembrane protein 198 [Source:MGI Symbol;Acc:MGI:2443133] toll-like receptor 11 [Source:MGI Symbol;Acc:MGI:3045226] immunoglobulin-like and fibronectin type III domain containing 1 [Source:MGI Symbol;Acc:MGI:3045352] lymphocyte transmembrane adaptor 1 [Source:MGI Symbol;Acc:MGI:2443362] phospholipase D family, member 4 [Source:MGI Symbol;Acc:MGI:2144765] basic helix-loop-helix family, member a15 [Source:MGI Symbol;Acc:MGI:891976] MAS-related GPR, member A6 [Source:MGI Symbol;Acc:MGI:3033107] ankyrin repeat domain 44 [Source:MGI Symbol;Acc:MGI:3045243] cell migration inducing protein, hyaluronan binding [Source:MGI Symbol;Acc:MGI:2443629] predicted gene 9873 [Source:MGI Symbol;Acc:MGI:3642403] [Source:MGI Symbol;Acc:MGI:109192] SH2 domain containing 6 [Source:MGI Symbol;Acc:MGI:1918380] predicted gene 5111 [Source:MGI Symbol;Acc:MGI:3645688] killer cell lectin-like receptor subfamily C, member 2 [Source:MGI Symbol;Acc:MGI:1336162] RIKEN cDNA A630001G21 gene [Source:MGI Symbol;Acc:MGI:2443131] G protein-coupled receptor kinase 4 [Source:MGI Symbol;Acc:MGI:95801] protein kinase C, beta [Source:MGI Symbol;Acc:MGI:97596] laminin, beta 2 [Source:MGI Symbol;Acc:MGI:99916] cytochrome P450, family 2, subfamily j, polypeptide 6 [Source:MGI Symbol;Acc:MGI:1270148] ribonuclease H2, large subunit [Source:MGI Symbol;Acc:MGI:1916974] ubiquitin-conjugating enzyme E2Q family-like 1 [Source:MGI Symbol;Acc:MGI:1924230]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

transmembrane protein 248 [Source:MGI Symbol;Acc:MGI:1918917] G protein-coupled receptor 141 [Source:MGI Symbol;Acc:MGI:2672983] cadherin 22 [Source:MGI Symbol;Acc:MGI:1341843] RIKEN cDNA 9030619P08 gene [Source:MGI Symbol;Acc:MGI:3612405] periaxin [Source:MGI Symbol;Acc:MGI:108176] FIC domain containing [Source:MGI Symbol;Acc:MGI:1098550] calcium channel, voltage-dependent, gamma subunit 8 [Source:MGI Symbol;Acc:MGI:1932376] chromobox 7 [Source:MGI Symbol;Acc:MGI:1196439] hormonally upregulated Neu-associated kinase [Source:MGI Symbol;Acc:MGI:1347352] thyroglobulin [Source:MGI Symbol;Acc:MGI:98733] tumor necrosis factor alpha induced protein 6 [Source:MGI Symbol;Acc:MGI:1195266] aldehyde dehydrogenase family 7, member A1 [Source:MGI Symbol;Acc:MGI:108186] plexin B1 [Source:MGI Symbol;Acc:MGI:2154238] transglutaminase 5 [Source:MGI Symbol;Acc:MGI:1921426] histocompatibility 2, T region locus 24 [Source:MGI Symbol;Acc:MGI:95958] predicted gene 12474 [Source:MGI Symbol;Acc:MGI:3649378] lectin, galactose binding, soluble 4 [Source:MGI Symbol;Acc:MGI:107536] zinc finger protein 14 [Source:MGI Symbol;Acc:MGI:99160] RIKEN cDNA D630008O14 gene [Source:MGI Symbol;Acc:MGI:3698880] SKI/DACH domain containing 1 [Source:MGI Symbol;Acc:MGI:1919918] histocompatibility 2, T region locus 3 [Source:MGI Symbol;Acc:MGI:95959] adrenomedullin 2 [Source:MGI Symbol;Acc:MGI:2675256] musashi RNA-binding protein 1 [Source:MGI Symbol;Acc:MGI:107376] leukemia inhibitory factor receptor [Source:MGI Symbol;Acc:MGI:96788] ADP-ribosylation factor GTPase activating protein 3 [Source:MGI Symbol;Acc:MGI:1913501] ras homolog family member B [Source:MGI Symbol;Acc:MGI:107949] signal peptidase complex subunit 3 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1923937] transmembrane protein 74 [Source:MGI Symbol;Acc:MGI:2443417] GTPase, IMAP family member 4 [Source:MGI Symbol;Acc:MGI:1349656] methyltransferase like 7A1 [Source:MGI Symbol;Acc:MGI:1916523] RIKEN cDNA 5830411N06 gene [Source:MGI Symbol;Acc:MGI:2443685] serine/arginine-rich splicing factor 12 [Source:MGI Symbol;Acc:MGI:2661424] TXK tyrosine kinase [Source:MGI Symbol;Acc:MGI:102960] potassium large conductance calcium-activated channel, subfamily M, beta member 4 [Source:MGI Symbol;Acc: contactin 1 [Source:MGI Symbol;Acc:MGI:105980] RAB39, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:2442855] Kruppel-like factor 2 (lung) [Source:MGI Symbol;Acc:MGI:1342772] phospholipase D family, member 5 [Source:MGI Symbol;Acc:MGI:2442056] RIKEN cDNA 9430025C20 gene [Source:MGI Symbol;Acc:MGI:3045277] thioesterase superfamily member 7 [Source:MGI Symbol;Acc:MGI:1921338] predicted gene 9967 [Source:MGI Symbol;Acc:MGI:3704300] predicted pseudogene 7353 [Source:MGI Symbol;Acc:MGI:3643014] T cell immunoglobulin and mucin domain containing 4 [Source:MGI Symbol;Acc:MGI:2445125] related RAS viral (r-ras) oncogene 2 [Source:MGI Symbol;Acc:MGI:1914172] RING1 and YY1 binding protein, pseudogene [Source:MGI Symbol;Acc:MGI:3648043] tescalcin-like [Source:MGI Symbol;Acc:MGI:1916551] RIKEN cDNA 1700034H15 gene [Source:MGI Symbol;Acc:MGI:1921515] oocyte secreted protein 2 [Source:MGI Symbol;Acc:MGI:2684945] transmembrane protein 150A [Source:MGI Symbol;Acc:MGI:2385244] nucleotide-binding oligomerization domain containing 2 [Source:MGI Symbol;Acc:MGI:2429397] cDNA sequence BC018473 [Source:MGI Symbol;Acc:MGI:3039625]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

regulator of G-protein signalling 9 binding protein [Source:MGI Symbol;Acc:MGI:2384418] melanoma inhibitory activity 3 [Source:MGI Symbol;Acc:MGI:2443183] glutamate receptor, ionotropic, kainate 2 (beta 2) [Source:MGI Symbol;Acc:MGI:95815] tripartite motif-containing 34A [Source:MGI Symbol;Acc:MGI:2137359] nanos C2HC-type zinc finger 3 [Source:MGI Symbol;Acc:MGI:2675387] carbonic anhydrase 10 [Source:MGI Symbol;Acc:MGI:1919855] collagen, type VIII, alpha 2 [Source:MGI Symbol;Acc:MGI:88464] par-6 family cell polarity regulator gamma [Source:MGI Symbol;Acc:MGI:2135606] leucine-rich repeats and guanylate kinase domain containing [Source:MGI Symbol;Acc:MGI:1921604] nuclear receptor coactivator 4 [Source:MGI Symbol;Acc:MGI:1350932] ligand dependent nuclear receptor interacting factor 1 [Source:MGI Symbol;Acc:MGI:2445214] centrosomal protein 70 [Source:MGI Symbol;Acc:MGI:1915371] membrane-spanning 4-domains, subfamily A, member 4B [Source:MGI Symbol;Acc:MGI:1913083] zinc finger protein 981 [Source:MGI Symbol;Acc:MGI:3700965] ARP3 actin-related protein 3B [Source:MGI Symbol;Acc:MGI:2661120] ligase I, DNA, ATP-dependent [Source:MGI Symbol;Acc:MGI:101789] trans-golgi network protein [Source:MGI Symbol;Acc:MGI:105080] transmembrane protein 154 [Source:MGI Symbol;Acc:MGI:2444725] zinc finger protein 658 [Source:MGI Symbol;Acc:MGI:2652821] olfactory receptor 90 [Source:MGI Symbol;Acc:MGI:2177473] GLI pathogenesis-related 1 (glioma) [Source:MGI Symbol;Acc:MGI:1920940] histone cluster 3, H2ba [Source:MGI Symbol;Acc:MGI:1925553] solute carrier family 35, member F3 [Source:MGI Symbol;Acc:MGI:2444426] ERO1-like beta (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1914725] N-acetyltransferase 8 (GCN5-related) family member 1 [Source:MGI Symbol;Acc:MGI:1913366] retinitis pigmentosa GTPase regulator interacting protein 1 [Source:MGI Symbol;Acc:MGI:1932134] SLP adaptor and CSK interacting membrane protein [Source:MGI Symbol;Acc:MGI:3610314] protease, serine 2 [Source:MGI Symbol;Acc:MGI:102759] ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 [S carbohydrate (chondroitin 6/keratan) sulfotransferase 3 [Source:MGI Symbol;Acc:MGI:1858224] ryanodine receptor 3 [Source:MGI Symbol;Acc:MGI:99684] tripartite motif-containing 30D [Source:MGI Symbol;Acc:MGI:3035181] multiple EGF-like-domains 6 [Source:MGI Symbol;Acc:MGI:1919351] zinc finger protein 105 [Source:MGI Symbol;Acc:MGI:1277119] calcium/calmodulin-dependent protein kinase II, beta [Source:MGI Symbol;Acc:MGI:88257] RIKEN cDNA 4933430I17 gene [Source:MGI Symbol;Acc:MGI:3045314] predicted gene 10036 [Source:MGI Symbol;Acc:MGI:3642334] , related sequence 7 [Source:MGI Symbol;Acc:MGI:99705] glutathione S-transferase, mu 1 [Source:MGI Symbol;Acc:MGI:95860] predicted gene 5431 [Source:MGI Symbol;Acc:MGI:3645205] predicted gene 5148 [Source:MGI Symbol;Acc:MGI:3646006] membrane metallo-endopeptidase-like 1 [Source:MGI Symbol;Acc:MGI:1351603] predicted gene 10037 [Source:MGI Symbol;Acc:MGI:3645096] predicted gene 12253 [Source:MGI Symbol;Acc:MGI:3651568] predicted gene 2531 [Source:MGI Symbol;Acc:MGI:3780699] calpain 11 [Source:MGI Symbol;Acc:MGI:1352490] coiled-coil serine rich 2 [Source:MGI Symbol;Acc:MGI:101859] potassium channel, subfamily T, member 1 [Source:MGI Symbol;Acc:MGI:1924627] potassium inwardly-rectifying channel, subfamily J, member 14 [Source:MGI Symbol;Acc:MGI:2384820] family with sequence similarity 57, member B [Source:MGI Symbol;Acc:MGI:1916202] RIKEN cDNA 9630013D21 gene [Source:MGI Symbol;Acc:MGI:2442649]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

enolase 1B, retrotransposed [Source:MGI Symbol;Acc:MGI:3648653] HOP homeobox [Source:MGI Symbol;Acc:MGI:1916782] predicted gene 8116 [Source:MGI Symbol;Acc:MGI:3648797] Rho guanine nucleotide exchange factor (GEF) 12 [Source:MGI Symbol;Acc:MGI:1916882] olfactory receptor 248 [Source:MGI Symbol;Acc:MGI:3030082] predicted gene 5292 [Source:MGI Symbol;Acc:MGI:3645663] C-type lectin domain family 4, member a4 [Source:MGI Symbol;Acc:MGI:3624119] flotillin 1 [Source:MGI Symbol;Acc:MGI:1100500] ribosomal protein S3A3 [Source:MGI Symbol;Acc:MGI:3643406] nurim (nuclear envelope membrane protein) [Source:MGI Symbol;Acc:MGI:2146855] regulator of G-protein signaling 3 [Source:MGI Symbol;Acc:MGI:1354734] sodium channel and clathrin linker 1 [Source:MGI Symbol;Acc:MGI:1914411] protein tyrosine phosphatase 4a3 [Source:MGI Symbol;Acc:MGI:1277098] a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14 [Source:MGI Sym neuronal pentraxin 2 [Source:MGI Symbol;Acc:MGI:1858209] predicted pseudogene 10073 [Source:MGI Symbol;Acc:MGI:3641908] transmembrane protein 26 [Source:MGI Symbol;Acc:MGI:2143537] predicted gene 12222 [Source:MGI Symbol;Acc:MGI:3649523] olfactory receptor 60 [Source:MGI Symbol;Acc:MGI:1333881] zinc finger protein 462 [Source:MGI Symbol;Acc:MGI:107690] neuregulin 2 [Source:MGI Symbol;Acc:MGI:1098246] carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 [Source:MGI Symbol;Acc:MGI:1916197] tripartite motif-containing 5 [Source:MGI Symbol;Acc:MGI:3646853] adhesion G protein-coupled receptor G3 [Source:MGI Symbol;Acc:MGI:1859670] sterile alpha motif domain containing 5 [Source:MGI Symbol;Acc:MGI:2444815] chemokine (C motif) receptor 1 [Source:MGI Symbol;Acc:MGI:1346338] histocompatibility 2, Q region locus 7 [Source:MGI Symbol;Acc:MGI:95936] interferon induced transmembrane protein 2 [Source:MGI Symbol;Acc:MGI:1933382] ribosomal protein L35A [Source:MGI Symbol;Acc:MGI:1928894] histone cluster 1, H4i [Source:MGI Symbol;Acc:MGI:2448432] ATPase, class I, type 8B, member 2 [Source:MGI Symbol;Acc:MGI:1859660] thymosin beta 15a [Source:MGI Symbol;Acc:MGI:1925728] inturned planar cell polarity protein [Source:MGI Symbol;Acc:MGI:2443752] ribosomal protein L26 [Source:MGI Symbol;Acc:MGI:106022] olfactory receptor 920 [Source:MGI Symbol;Acc:MGI:3030754] mast cell protease 4 [Source:MGI Symbol;Acc:MGI:96940] limbic system-associated membrane protein [Source:MGI Symbol;Acc:MGI:1261760] B cell linker [Source:MGI Symbol;Acc:MGI:96878] orosomucoid 2 [Source:MGI Symbol;Acc:MGI:97444] adhesion G protein-coupled receptor G5 [Source:MGI Symbol;Acc:MGI:2685955] glycerophosphodiester phosphodiesterase domain containing 1 [Source:MGI Symbol;Acc:MGI:1913819] ribosomal protein L21, pseudogene 8 [Source:MGI Symbol;Acc:MGI:3648345] killer cell lectin-like receptor, subfamily A, member 6 [Source:MGI Symbol;Acc:MGI:101902] predicted gene 14292 [Source:MGI Symbol;Acc:MGI:3649964] olfactory receptor 99 [Source:MGI Symbol;Acc:MGI:2177482] ribosomal protein L34 [Source:MGI Symbol;Acc:MGI:1915686] immunity-related GTPase family, cinema 1 [Source:MGI Symbol;Acc:MGI:2685948] protein glucosylgalactosylhydroxylysine glucosidase [Source:MGI Symbol;Acc:MGI:2444047] phosphoglycerate kinase 1 [Source:MGI Symbol;Acc:MGI:97555] CD200 receptor 4 [Source:MGI Symbol;Acc:MGI:3036289] predicted gene 10110 [Source:MGI Symbol;Acc:MGI:3641718]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

eosinophil-associated, ribonuclease A family, member 6 [Source:MGI Symbol;Acc:MGI:1890463] glutamine repeat protein 1 [Source:MGI Symbol;Acc:MGI:108038] serine (or cysteine) peptidase inhibitor, clade B, member 2 [Source:MGI Symbol;Acc:MGI:97609] predicted gene 15772 [Source:MGI Symbol;Acc:MGI:3805541] fatty acid binding protein 4, adipocyte [Source:MGI Symbol;Acc:MGI:88038] zinc finger protein 534 [Source:MGI Symbol;Acc:MGI:3650650] natural cytotoxicity triggering receptor 1 [Source:MGI Symbol;Acc:MGI:1336212] cannabinoid receptor 2 (macrophage) [Source:MGI Symbol;Acc:MGI:104650] ribosomal protein S3A2 [Source:MGI Symbol;Acc:MGI:3642853] chitinase, acidic 1 [Source:MGI Symbol;Acc:MGI:1932052] t-complex protein 11 [Source:MGI Symbol;Acc:MGI:98544] cadherin-like and PC- domain containing 1 [Source:MGI Symbol;Acc:MGI:2444814] neuregulin 1 [Source:MGI Symbol;Acc:MGI:96083] islet cell autoantigen 1 [Source:MGI Symbol;Acc:MGI:96391] kinesin family member 1B [Source:MGI Symbol;Acc:MGI:108426] diacylglycerol kinase, epsilon, opposite strand [Source:MGI Symbol;Acc:MGI:3041185] ribosomal protein S4-like [Source:MGI Symbol;Acc:MGI:1913434] glutamate receptor, metabotropic 4 [Source:MGI Symbol;Acc:MGI:1351341] transmembrane protein 117 [Source:MGI Symbol;Acc:MGI:2444580] RIKEN cDNA 1190007I07 gene [Source:MGI Symbol;Acc:MGI:3698433] solute carrier family 39 (zinc transporter), member 4 [Source:MGI Symbol;Acc:MGI:1919277] cDNA sequence BC023105 [Source:MGI Symbol;Acc:MGI:2384767] WSC domain containing 2 [Source:MGI Symbol;Acc:MGI:2445030] B9 2 [Source:MGI Symbol;Acc:MGI:2387643] ubiquitin-conjugating enzyme E2D 2B [Source:MGI Symbol;Acc:MGI:1920568] RIKEN cDNA 2010109I03 gene [Source:MGI Symbol;Acc:MGI:1914288] stathmin domain containing 1 [Source:MGI Symbol;Acc:MGI:2686420] olfactory receptor 98 [Source:MGI Symbol;Acc:MGI:2177481] predicted pseudogene 8730 [Source:MGI Symbol;Acc:MGI:3644565] sideroflexin 4 [Source:MGI Symbol;Acc:MGI:2137680] peptidase D [Source:MGI Symbol;Acc:MGI:97542] izumo sperm-egg fusion 1 [Source:MGI Symbol;Acc:MGI:1920706] predicted gene 4735 [Source:MGI Symbol;Acc:MGI:3645521] GTPase, IMAP family member 8 [Source:MGI Symbol;Acc:MGI:2685303] contactin 4 [Source:MGI Symbol;Acc:MGI:1095737] SIVA1, apoptosis-inducing factor [Source:MGI Symbol;Acc:MGI:1353606] mitochondrially encoded 12S rRNA [Source:MGI Symbol;Acc:MGI:102493] mitochondrially encoded tRNA cysteine [Source:MGI Symbol;Acc:MGI:102490] predicted gene, 22748 [Source:MGI Symbol;Acc:MGI:5452525] small nucleolar RNA, C/D box 104 [Source:MGI Symbol;Acc:MGI:3819515] microRNA 27a [Source:MGI Symbol;Acc:MGI:2676902] microRNA 23a [Source:MGI Symbol;Acc:MGI:2676897] interferon induced transmembrane protein 7 [Source:MGI Symbol;Acc:MGI:1921732] zinc finger protein 987 [Source:MGI Symbol;Acc:MGI:3702694] predicted gene 12866 [Source:MGI Symbol;Acc:MGI:3649462] predicted gene 12666 [Source:MGI Symbol;Acc:MGI:3650864] cell division cycle 26 [Source:MGI Symbol;Acc:MGI:1913690] AT rich interactive domain 3C (BRIGHT-like) [Source:MGI Symbol;Acc:MGI:3650624] tripartite motif-containing 12A [Source:MGI Symbol;Acc:MGI:1923931] serine (or cysteine) peptidase inhibitor, clade A, member 3F [Source:MGI Symbol;Acc:MGI:2182838] vomeronasal 2, receptor 57 [Source:MGI Symbol;Acc:MGI:3703084]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

predicted pseudogene 6969 [Source:MGI Symbol;Acc:MGI:3645320] zinc finger protein 932 [Source:MGI Symbol;Acc:MGI:1916754] tectonin beta-propeller repeat containing 1 [Source:MGI Symbol;Acc:MGI:1917631] olfactory receptor 417 [Source:MGI Symbol;Acc:MGI:3030251] interferon activated gene 208 [Source:MGI Symbol;Acc:MGI:2442822] zinc finger and BTB domain containing 16 [Source:MGI Symbol;Acc:MGI:103222] pregnancy specific glycoprotein 16 [Source:MGI Symbol;Acc:MGI:1347249] myosin 1H [Source:MGI Symbol;Acc:MGI:1914674] predicted gene 3608 [Source:MGI Symbol;Acc:MGI:3804932] ribosomal protein S15A, pseudogene 5 [Source:MGI Symbol;Acc:MGI:3642245] immunoglobulin joining chain [Source:MGI Symbol;Acc:MGI:96493] histocompatibility 2, K region locus 2 [Source:MGI Symbol;Acc:MGI:95906] leucine rich repeat containing 66 [Source:MGI Symbol;Acc:MGI:2387634] cyclic nucleotide gated channel alpha 1 [Source:MGI Symbol;Acc:MGI:88436] histocompatibility 2, Q region locus 10 [Source:MGI Symbol;Acc:MGI:95929] predicted gene 16223 [Source:MGI Symbol;Acc:MGI:3648966] tubulin, alpha 3B [Source:MGI Symbol;Acc:MGI:1095408] killer cell lectin-like receptor, subfamily A, member 7 [Source:MGI Symbol;Acc:MGI:101901] proliferating cell nuclear antigen pseudogene 2 [Source:MGI Symbol;Acc:MGI:97505] killer cell lectin-like receptor family I member 1 [Source:MGI Symbol;Acc:MGI:3530275] zinc finger protein 991 [Source:MGI Symbol;Acc:MGI:3701604] centromere protein M [Source:MGI Symbol;Acc:MGI:1913820] tumor necrosis factor receptor superfamily, member 13c [Source:MGI Symbol;Acc:MGI:1919299] synovial sarcoma, X member B9 [Source:MGI Symbol;Acc:MGI:2446778] interleukin 2 receptor, beta chain [Source:MGI Symbol;Acc:MGI:96550] apolipoprotein L 7b [Source:MGI Symbol;Acc:MGI:3583950] olfactory receptor 461 [Source:MGI Symbol;Acc:MGI:3030295] EF hand and coiled-coil domain containing 1 [Source:MGI Symbol;Acc:MGI:3611451] sepiapterin reductase pseudogene 1 [Source:MGI Symbol;Acc:MGI:1345187] solute carrier family 4, sodium bicarbonate cotransporter, member 5 [Source:MGI Symbol;Acc:MGI:2443220] ribonuclease, RNase A family, 12 (non-active) [Source:MGI Symbol;Acc:MGI:3528588] predicted gene 7676 [Source:MGI Symbol;Acc:MGI:3644053] C-type lectin domain family 16, member A [Source:MGI Symbol;Acc:MGI:1921624] filamin C, gamma [Source:MGI Symbol;Acc:MGI:95557] transmembrane protein 167B [Source:MGI Symbol;Acc:MGI:1914745] proline/serine-rich coiled-coil 1 [Source:MGI Symbol;Acc:MGI:1913099] predicted gene 128 [Source:MGI Symbol;Acc:MGI:2684974] selenium binding protein 1 [Source:MGI Symbol;Acc:MGI:96825] selenium binding protein 2 [Source:MGI Symbol;Acc:MGI:104859] solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 [Source:MGI Symbo zinc finger protein 874a [Source:MGI Symbol;Acc:MGI:3040703] dual specificity phosphatase 22 [Source:MGI Symbol;Acc:MGI:1915926] histone cluster 1, H3c [Source:MGI Symbol;Acc:MGI:2448320] predicted gene 4925 [Source:MGI Symbol;Acc:MGI:3643371] CD300 molecule like family member D3 [Source:MGI Symbol;Acc:MGI:2687214] zinc finger protein 820 [Source:MGI Symbol;Acc:MGI:1922674] transmembrane protein 100 [Source:MGI Symbol;Acc:MGI:1915138] fructose bisphosphatase 1 [Source:MGI Symbol;Acc:MGI:95492] AHNAK nucleoprotein (desmoyokin) [Source:MGI Symbol;Acc:MGI:1316648] poly(A)binding protein nuclear 1-like [Source:MGI Symbol;Acc:MGI:2685954] hemoglobin alpha, adult chain 2 [Source:MGI Symbol;Acc:MGI:96016]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 [Source:MGI Symbol;Acc:MGI:2142841] predicted pseudogene 5356 [Source:MGI Symbol;Acc:MGI:3643649] predicted pseudogene 7125 [Source:MGI Symbol;Acc:MGI:3645829] malignant fibrous histiocytoma amplified sequence 1 [Source:MGI Symbol;Acc:MGI:1098644] GDP-mannose pyrophosphorylase B [Source:MGI Symbol;Acc:MGI:2660880] DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 [Source:MGI Symbol;Acc:MGI:3642857] sodium channel, voltage-gated, type II, beta [Source:MGI Symbol;Acc:MGI:106921] myelin protein zero-like 3 [Source:MGI Symbol;Acc:MGI:2442647] integrin, alpha D [Source:MGI Symbol;Acc:MGI:3578624] capping protein (actin filament) muscle Z-line, alpha 1 [Source:MGI Symbol;Acc:MGI:106227] NLR family, pyrin domain containing 1B [Source:MGI Symbol;Acc:MGI:3582959] transmembrane protein 256 [Source:MGI Symbol;Acc:MGI:1916436] heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 [Source:MGI Symbol;Acc:MGI:1333853] ADP-ribosyltransferase 5 [Source:MGI Symbol;Acc:MGI:107948] interferon activated gene 214 [Source:MGI Symbol;Acc:MGI:3584522] Fc receptor-like 6 [Source:MGI Symbol;Acc:MGI:3618339] repulsive guidance molecule family member A [Source:MGI Symbol;Acc:MGI:2679262] netrin 5 [Source:MGI Symbol;Acc:MGI:2685330] zinc finger protein 992 [Source:MGI Symbol;Acc:MGI:3700963] transmembrane protein 200B [Source:MGI Symbol;Acc:MGI:3646343] RNA binding motif protein 44 [Source:MGI Symbol;Acc:MGI:2685663] RNA binding motif protein 47 [Source:MGI Symbol;Acc:MGI:2384294] PNMA-like 2 [Source:MGI Symbol;Acc:MGI:3645856] Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 [Source:MGI Symbol;Acc:MGI leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 [Source:MGI Symbol;Acc:MGI RAS, guanyl releasing protein 3 [Source:MGI Symbol;Acc:MGI:3028579] predicted gene 156 [Source:MGI Symbol;Acc:MGI:2685002] NLR family, apoptosis inhibitory protein 5 [Source:MGI Symbol;Acc:MGI:1298220] synapse differentiation inducing 1 like [Source:MGI Symbol;Acc:MGI:2685107] epithelial cell transforming sequence 2 oncogene-like [Source:MGI Symbol;Acc:MGI:3641723] cyclin B1 interacting protein 1 [Source:MGI Symbol;Acc:MGI:2685134] RIKEN cDNA 3425401B19 gene [Source:MGI Symbol;Acc:MGI:3588196] aldo-keto reductase family 1, member C19 [Source:MGI Symbol;Acc:MGI:2653678] T cell immunoreceptor with Ig and ITIM domains [Source:MGI Symbol;Acc:MGI:3642260] cDNA sequence BC100530 [Source:MGI Symbol;Acc:MGI:3696883] predicted gene 5874 [Source:MGI Symbol;Acc:MGI:3648027] syntaxin-binding protein 3, pseudogene [Source:MGI Symbol;Acc:MGI:3586869] colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) [Source:MGI Symbol;Acc:MGI: colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) [Source:MGI Symbol;Acc:MGI zinc fingers and 2 [Source:MGI Symbol;Acc:MGI:2683087] RIKEN cDNA 6820431F20 gene [Source:MGI Symbol;Acc:MGI:3694236] adenomatosis polyposis coli down-regulated 1 [Source:MGI Symbol;Acc:MGI:3513977] , ribonuclease, RNase A family, 5 [Source:MGI Symbol;Acc:MGI:88022] tripartite motif-containing 6 [Source:MGI Symbol;Acc:MGI:2137352] predicted gene 8420 [Source:MGI Symbol;Acc:MGI:3645594] protein phosphatase 1, regulatory subunit 3E [Source:MGI Symbol;Acc:MGI:2145790] eosinophil-associated, ribonuclease A family, member 2 [Source:MGI Symbol;Acc:MGI:108020] eosinophil-associated, ribonuclease A family, pseudogene 2 [Source:MGI Symbol;Acc:MGI:1890466] predicted gene 10382 [Source:MGI Symbol;Acc:MGI:3647829] predicted gene 10384 [Source:MGI Symbol;Acc:MGI:3641812] zinc finger protein 9 [Source:MGI Symbol;Acc:MGI:99210]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

DNA segment, Chr 6, ERATO Doi 474, expressed [Source:MGI Symbol;Acc:MGI:1196315] killer cell lectin-like receptor subfamily A, member 11, pseudogene [Source:MGI Symbol;Acc:MGI:1321092] killer cell lectin-like receptor subfamily A, member 10 [Source:MGI Symbol;Acc:MGI:1321093] zinc finger protein 951 [Source:MGI Symbol;Acc:MGI:2441896] nuclear transcription factor, X-box binding-like 1 [Source:MGI Symbol;Acc:MGI:1923646] RIKEN cDNA 4933439C10 gene [Source:MGI Symbol;Acc:MGI:1921726] predicted gene 10434 [Source:MGI Symbol;Acc:MGI:3708552] G protein-coupled receptor 174 [Source:MGI Symbol;Acc:MGI:2685222] immunoglobulin kappa chain variable 4-71 [Source:MGI Symbol;Acc:MGI:4439654] predicted gene 12000 [Source:MGI Symbol;Acc:MGI:3651524] predicted pseudogene 6594 [Source:MGI Symbol;Acc:MGI:3643873] predicted gene 8909 [Source:MGI Symbol;Acc:MGI:3704134] predicted gene 10499 [Source:MGI Symbol;Acc:MGI:3702919] histocompatibility 2, T region locus, pseudogene [Source:MGI Symbol;Acc:MGI:2442805] histocompatibility 2, blastocyst [Source:MGI Symbol;Acc:MGI:892004] predicted gene 6034 [Source:MGI Symbol;Acc:MGI:3646212] interferon activated gene 204 [Source:MGI Symbol;Acc:MGI:96429] interferon activated gene 207 [Source:MGI Symbol;Acc:MGI:2138302] SH2 domain containing 1B2 [Source:MGI Symbol;Acc:MGI:3622649] RIKEN cDNA F830208F22 gene [Source:MGI Symbol;Acc:MGI:3588261] Riken cDNA E330020D12 gene [Source:MGI Symbol;Acc:MGI:3761270] WD repeat and FYVE domain containing 1 [Source:MGI Symbol;Acc:MGI:1916618] post-GPI attachment to 1 [Source:MGI Symbol;Acc:MGI:2443342] predicted gene 13241 [Source:MGI Symbol;Acc:MGI:3649920] Tmem51 opposite strand 1 [Source:MGI Symbol;Acc:MGI:3642733] predicted gene 5600 [Source:MGI Symbol;Acc:MGI:3645703] interleukin 11 receptor, alpha chain 1 [Source:MGI Symbol;Acc:MGI:107426] predicted gene 1966 [Source:MGI Symbol;Acc:MGI:3584360] olfactory receptor 632 [Source:MGI Symbol;Acc:MGI:3030466] serum amyloid A 1 [Source:MGI Symbol;Acc:MGI:98221] neurotrophin 5 [Source:MGI Symbol;Acc:MGI:97381] ribosomal protein L13A [Source:MGI Symbol;Acc:MGI:1351455] zinc finger protein 976 [Source:MGI Symbol;Acc:MGI:3036263] zinc finger protein 791 [Source:MGI Symbol;Acc:MGI:3648473] chloride channel accessory 4B [Source:MGI Symbol;Acc:MGI:2139790] predicted gene 10654 [Source:MGI Symbol;Acc:MGI:3643366] carcinoembryonic antigen-related cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:1347245] pleckstrin homology like domain, family B, member 3 [Source:MGI Symbol;Acc:MGI:3642959] predicted gene 6166 [Source:MGI Symbol;Acc:MGI:3645893] oviductal glycoprotein 1 [Source:MGI Symbol;Acc:MGI:106661] coiled-coil domain containing 61 [Source:MGI Symbol;Acc:MGI:2685005] predicted gene 14548 [Source:MGI Symbol;Acc:MGI:3709645] predicted pseudogene 10693 [Source:MGI Symbol;Acc:MGI:3704277] S100 calcium binding protein A16 [Source:MGI Symbol;Acc:MGI:1915110] SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1914879 predicted pseudogene 10704 [Source:MGI Symbol;Acc:MGI:3642446] FAT atypical cadherin 3 [Source:MGI Symbol;Acc:MGI:2444314] potassium voltage-gated channel, subfamily G, member 1 [Source:MGI Symbol;Acc:MGI:3616086] zinc finger, NFX1-type containing 1, antisense RNA 1 [Source:MGI Symbol;Acc:MGI:1916199] microsomal glutathione S-transferase 2 [Source:MGI Symbol;Acc:MGI:2448481] tubulin tyrosine ligase-like family, member 9 [Source:MGI Symbol;Acc:MGI:1913589]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

defensin beta 26 [Source:MGI Symbol;Acc:MGI:3643488] zinc finger protein 345 [Source:MGI Symbol;Acc:MGI:3652219] predicted gene 21994 [Source:MGI Symbol;Acc:MGI:5439751] [Source:MGI Symbol;Acc:MGI:98736] zinc finger protein 934 [Source:MGI Symbol;Acc:MGI:1924367] spectrin beta, non-erythrocytic 5 [Source:MGI Symbol;Acc:MGI:2685200] tyrosine kinase, non-receptor 2, opposite strand [Source:MGI Symbol;Acc:MGI:3642140] brain expressed family member 6 [Source:MGI Symbol;Acc:MGI:3588247] carnosine synthase 1 [Source:MGI Symbol;Acc:MGI:2147595] kelch-like 41 [Source:MGI Symbol;Acc:MGI:2683854] reprimo, TP53 dependent G2 arrest mediator candidate [Source:MGI Symbol;Acc:MGI:1915124] predicted gene 13443 [Source:MGI Symbol;Acc:MGI:3649615] photoreceptor disc component [Source:MGI Symbol;Acc:MGI:3649529] small integral membrane protein 6 [Source:MGI Symbol;Acc:MGI:1915778] lymphocyte antigen 6 complex, locus A [Source:MGI Symbol;Acc:MGI:107527] selenoprotein S [Source:MGI Symbol;Acc:MGI:95994] microRNA 704 [Source:MGI Symbol;Acc:MGI:3629672] selenoprotein H [Source:MGI Symbol;Acc:MGI:1919907] T cell receptor beta, variable 14 [Source:MGI Symbol;Acc:MGI:98587] T cell receptor beta joining 1-1 [Source:MGI Symbol;Acc:MGI:4439570] T cell receptor beta joining 1-2 [Source:MGI Symbol;Acc:MGI:4439569] T cell receptor beta joining 1-3 [Source:MGI Symbol;Acc:MGI:4439568] T cell receptor beta joining 1-4 [Source:MGI Symbol;Acc:MGI:4439567] T cell receptor beta joining 1-5 [Source:MGI Symbol;Acc:MGI:4439566] T cell receptor beta joining 1-6 [Source:MGI Symbol;Acc:MGI:4439575] T cell receptor beta joining 1-7 [Source:MGI Symbol;Acc:MGI:4439574] T cell receptor beta joining 2-5 [Source:MGI Symbol;Acc:MGI:4439899] T cell receptor beta, constant 2 [Source:MGI Symbol;Acc:MGI:4835227] T cell receptor beta, variable 31 [Source:MGI Symbol;Acc:MGI:98588] predicted gene, 20730 [Source:MGI Symbol;Acc:MGI:5313039] immunoglobulin kappa chain variable 2-137 [Source:MGI Symbol;Acc:MGI:4439879] immunoglobulin kappa variable 1-131 [Source:MGI Symbol;Acc:MGI:3645551] immunoglobulin kappa variable 17-127 [Source:MGI Symbol;Acc:MGI:3646891] immunoglobulin kappa variable 9-123 [Source:MGI Symbol;Acc:MGI:3643848] immunoglobulin kappa variable 17-121 [Source:MGI Symbol;Acc:MGI:3647671] immunoglobulin kappa variable 2-112 [Source:MGI Symbol;Acc:MGI:3644894] immunoglobulin kappa variable 16-104 [Source:MGI Symbol;Acc:MGI:2685913] immunoglobulin kappa chain variable 15-103 [Source:MGI Symbol;Acc:MGI:96513] immunoglobulin kappa variable 12-98 [Source:MGI Symbol;Acc:MGI:4439560] immunoglobulin kappa chain variable 4-91 [Source:MGI Symbol;Acc:MGI:3642277] immunoglobulin kappa chain variable 12-89 [Source:MGI Symbol;Acc:MGI:4439829] immunoglobulin kappa chain variable 1-88 [Source:MGI Symbol;Acc:MGI:4439828] immunoglobulin kappa variable 4-86 [Source:MGI Symbol;Acc:MGI:2685305] immunoglobulin kappa chain variable 13-84 [Source:MGI Symbol;Acc:MGI:96514] immunoglobulin kappa variable 4-81 [Source:MGI Symbol;Acc:MGI:2685306] immunoglobulin kappa variable 4-80 [Source:MGI Symbol;Acc:MGI:4439653] immunoglobulin kappa variable 4-79 [Source:MGI Symbol;Acc:MGI:2685040] immunoglobulin kappa variable 4-74 [Source:MGI Symbol;Acc:MGI:3779447] immunoglobulin kappa chain variable 4-72 [Source:MGI Symbol;Acc:MGI:2686345] immunoglobulin kappa chain variable 4-70 [Source:MGI Symbol;Acc:MGI:2686348] immunoglobulin kappa variable 4-68 [Source:MGI Symbol;Acc:MGI:2686265]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

immunoglobulin kappa variable 4-63 [Source:MGI Symbol;Acc:MGI:3645235] immunoglobulin kappa chain variable 4-61 [Source:MGI Symbol;Acc:MGI:4439819] immunoglobulin kappa variable 4-57-1 [Source:MGI Symbol;Acc:MGI:2686264] immunoglobulin kappa variable 4-57 [Source:MGI Symbol;Acc:MGI:2685035] immunoglobulin kappa variable 4-50 [Source:MGI Symbol;Acc:MGI:2685915] immunoglobulin kappa variable 5-48 [Source:MGI Symbol;Acc:MGI:3642817] immunoglobulin kappa variable 12-46 [Source:MGI Symbol;Acc:MGI:4439773] immunoglobulin kappa variable 5-37 [Source:MGI Symbol;Acc:MGI:2686256] immunoglobulin kappa chain variable 18-36 [Source:MGI Symbol;Acc:MGI:4439613] immunoglobulin kappa variable 1-35 [Source:MGI Symbol;Acc:MGI:4439612] immunoglobulin kappa variable 6-32 [Source:MGI Symbol;Acc:MGI:3641634] immunoglobulin kappa chain variable 8-30 [Source:MGI Symbol;Acc:MGI:3642250] immunoglobulin kappa chain variable 8-27 [Source:MGI Symbol;Acc:MGI:4439868] immunoglobulin kappa variable 8-26 [Source:MGI Symbol;Acc:MGI:4439869] immunoglobulin kappa chain variable 8-24 [Source:MGI Symbol;Acc:MGI:4947958] immunoglobulin kappa variable 8-21 [Source:MGI Symbol;Acc:MGI:1330840] immunoglobulin kappa variable 8-18 [Source:MGI Symbol;Acc:MGI:1330845] immunoglobulin kappa variable 6-13 [Source:MGI Symbol;Acc:MGI:1330829] immunoglobulin kappa variable 3-10 [Source:MGI Symbol;Acc:MGI:1330821] immunoglobulin kappa variable 3-7 [Source:MGI Symbol;Acc:MGI:1330852] immunoglobulin kappa joining 1 [Source:MGI Symbol;Acc:MGI:1316689] immunoglobulin kappa joining 2 [Source:MGI Symbol;Acc:MGI:1316690] immunoglobulin kappa joining 3 [Source:MGI Symbol;Acc:MGI:1316691] immunoglobulin kappa joining 4 [Source:MGI Symbol;Acc:MGI:1316692] immunoglobulin kappa joining 5 [Source:MGI Symbol;Acc:MGI:1316738] immunoglobulin kappa constant [Source:MGI Symbol;Acc:MGI:96495] Immunoglobulin heavy constant gamma 3 [Source:MGI Symbol;Acc:MGI:2144790] immunoglobulin heavy constant mu [Source:MGI Symbol;Acc:MGI:96448] immunoglobulin heavy joining 4 [Source:MGI Symbol;Acc:MGI:4439658] immunoglobulin heavy joining 3 [Source:MGI Symbol;Acc:MGI:4439767] immunoglobulin heavy joining 2 [Source:MGI Symbol;Acc:MGI:4439803] immunoglobulin heavy joining 1 [Source:MGI Symbol;Acc:MGI:4439802] immunoglobulin heavy diversity 1-1 [Source:MGI Symbol;Acc:MGI:4439871] immunoglobulin heavy variable 5-2 [Source:MGI Symbol;Acc:MGI:4439893] immunoglobulin heavy variable 2-6-8 [Source:MGI Symbol;Acc:MGI:4439811] immunoglobulin heavy variable 7-3 [Source:MGI Symbol;Acc:MGI:4439766] immunoglobulin heavy variable 7-2 [Source:MGI Symbol;Acc:MGI:4439623] immunoglobulin heavy variable 4-1 [Source:MGI Symbol;Acc:MGI:4439536] immunoglobulin heavy variable 7-1 [Source:MGI Symbol;Acc:MGI:4439622] immunoglobulin heavy variable 14-4 [Source:MGI Symbol;Acc:MGI:4439765] immunoglobulin heavy variable 7-4 [Source:MGI Symbol;Acc:MGI:4439763] immunoglobulin heavy variable 13-2 [Source:MGI Symbol;Acc:MGI:3705861] immunoglobulin heavy variable 3-6 [Source:MGI Symbol;Acc:MGI:4439856] immunoglobulin heavy variable V3-8 [Source:MGI Symbol;Acc:MGI:3645298] immunoglobulin heavy variable V12-3 [Source:MGI Symbol;Acc:MGI:3646760] immunoglobulin heavy variable 6-6 [Source:MGI Symbol;Acc:MGI:4439619] immunoglobulin heavy variable V15-2 [Source:MGI Symbol;Acc:MGI:4947963] immunoglobulin heavy variable V1-18 [Source:MGI Symbol;Acc:MGI:4439780] immunoglobulin heavy variable 1-47 [Source:MGI Symbol;Acc:MGI:4439890] immunoglobulin heavy variable V8-12 [Source:MGI Symbol;Acc:MGI:3642873] T cell receptor gamma, variable 4 [Source:MGI Symbol;Acc:MGI:98634]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

T-cell receptor gamma, constant 2 [Source:MGI Symbol;Acc:MGI:98626] T cell receptor gamma variable 2 [Source:MGI Symbol;Acc:MGI:98632] T cell receptor gamma, variable 1 [Source:MGI Symbol;Acc:MGI:98631] T cell receptor alpha variable 13-2 [Source:MGI Symbol;Acc:MGI:3651611] T cell receptor delta joining 1 [Source:MGI Symbol;Acc:MGI:4819753] T cell receptor delta joining 2 [Source:MGI Symbol;Acc:MGI:4887422] T cell receptor alpha constant [Source:MGI Symbol;Acc:MGI:4439838] immunoglobulin lambda variable 1 [Source:MGI Symbol;Acc:MGI:96530] immunoglobulin lambda constant 2 [Source:MGI Symbol;Acc:MGI:99547] immunoglobulin lambda variable 3 [Source:MGI Symbol;Acc:MGI:3645509] immunoglobulin lambda variable 2 [Source:MGI Symbol;Acc:MGI:99548] predicted gene, 23251 [Source:MGI Symbol;Acc:MGI:5453028] predicted gene, 22779 [Source:MGI Symbol;Acc:MGI:5452556] RIKEN cDNA F630028O10 gene [Source:MGI Symbol;Acc:MGI:3641813] cDNA sequence AK157302 [Source:MGI Symbol;Acc:MGI:3574096] predicted gene 16503 [Source:MGI Symbol;Acc:MGI:3642127] glutamate rich 3 [Source:MGI Symbol;Acc:MGI:1919095] predicted gene 15610 [Source:MGI Symbol;Acc:MGI:3783056] RNA binding motif protein 8A2 [Source:MGI Symbol;Acc:MGI:3612447] antisense Igf2r RNA [Source:MGI Symbol;Acc:MGI:1353471] high mobility group AT-hook 1B [Source:MGI Symbol;Acc:MGI:96161] mitochondrial ribosomal protein L48 pseudogene [Source:MGI Symbol;Acc:MGI:3050089] cilia and flagella associated protein 74 [Source:MGI Symbol;Acc:MGI:1917130] zinc finger protein 984 [Source:MGI Symbol;Acc:MGI:3651978] zinc finger protein 990 [Source:MGI Symbol;Acc:MGI:3652161] RIKEN cDNA 2310026L22 gene [Source:MGI Symbol;Acc:MGI:1916844] aurora kinase A and ninein interacting protein [Source:MGI Symbol;Acc:MGI:1917135] family with sequence similarity 229, member A [Source:MGI Symbol;Acc:MGI:1915483] predicted gene 11735 [Source:MGI Symbol;Acc:MGI:3713525] predicted gene 4070 [Source:MGI Symbol;Acc:MGI:3782245] HAUS augmin-like complex, subunit 5 [Source:MGI Symbol;Acc:MGI:1919159] zinc finger protein 541 [Source:MGI Symbol;Acc:MGI:3647699] calcium channel, voltage-dependent, gamma subunit 6 [Source:MGI Symbol;Acc:MGI:1859168] histone cluster 3, H2a [Source:MGI Symbol;Acc:MGI:2448458] predicted gene 14443 [Source:MGI Symbol;Acc:MGI:3652324] T cell specific GTPase 2 [Source:MGI Symbol;Acc:MGI:3710083] Rho GTPase activating protein 8 [Source:MGI Symbol;Acc:MGI:1920417] zinc finger protein 429 [Source:MGI Symbol;Acc:MGI:1920057] lymphocyte antigen 6 complex, locus C1 [Source:MGI Symbol;Acc:MGI:96882] collagen, type XXII, alpha 1 [Source:MGI Symbol;Acc:MGI:1916950] myocyte enhancer factor 2B [Source:MGI Symbol;Acc:MGI:104526] prion protein [Source:MGI Symbol;Acc:MGI:97769] Kv channel interacting protein 3, calsenilin [Source:MGI Symbol;Acc:MGI:1929258] predicted gene 14085 [Source:MGI Symbol;Acc:MGI:3702173] KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 [Source:MGI Symbol;Acc:MGI:19141 predicted pseudogene 8818 [Source:MGI Symbol;Acc:MGI:3645903] toll-like receptor 5 [Source:MGI Symbol;Acc:MGI:1858171] predicted gene 8778 [Source:MGI Symbol;Acc:MGI:3779812] chemokine (C-C motif) receptor 5 [Source:MGI Symbol;Acc:MGI:107182] killer cell lectin-like receptor subfamily B member 1B [Source:MGI Symbol;Acc:MGI:107539] killer cell lectin-like receptor subfamily B member 1 [Source:MGI Symbol;Acc:MGI:96877]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

guanylate binding protein 4 [Source:MGI Symbol;Acc:MGI:97072] 5, 10-methenyltetrahydrofolate synthetase-like [Source:MGI Symbol;Acc:MGI:3780550] UTP14B small subunit processome component [Source:MGI Symbol;Acc:MGI:2445092] NHS-like 2 [Source:MGI Symbol;Acc:MGI:3645090] predicted gene 11127 [Source:MGI Symbol;Acc:MGI:3779381] histocompatibility 2, Q region locus 1 [Source:MGI Symbol;Acc:MGI:95928] histocompatibility 2, class II, locus Mb1 [Source:MGI Symbol;Acc:MGI:95922] membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) [Source:MGI Symbol;Acc:MGI:2386681] kinesin family member C1 [Source:MGI Symbol;Acc:MGI:109596] aldehyde oxidase 2 [Source:MGI Symbol;Acc:MGI:3529596] COLCA2 homolog [Source:MGI Symbol;Acc:MGI:2685530] recombination signal binding protein for immunoglobulin kappa J region, pseudogene 3 [Source:MGI Symbol;Ac predicted gene 17193 [Source:MGI Symbol;Acc:MGI:4938020] RIKEN cDNA 2610203C22 gene [Source:MGI Symbol;Acc:MGI:1919731] UL16 binding protein 1 [Source:MGI Symbol;Acc:MGI:1925027] killer cell lectin-like receptor, subfamily A, member 4 [Source:MGI Symbol;Acc:MGI:101904] killer cell lectin-like receptor, subfamily A, member 1 [Source:MGI Symbol;Acc:MGI:101907] predicted gene 11273 [Source:MGI Symbol;Acc:MGI:3649411] EEF1A lysine methyltransferase 3 [Source:MGI Symbol;Acc:MGI:3645330] ATPase, H+ transporting, lysosomal V0 subunit C, pseudogene 2 [Source:MGI Symbol;Acc:MGI:2151816] predicted gene 6368 [Source:MGI Symbol;Acc:MGI:3644537] predicted gene 11645 [Source:MGI Symbol;Acc:MGI:3652133] predicted gene 15925 [Source:MGI Symbol;Acc:MGI:3801830] predicted gene 9208 [Source:MGI Symbol;Acc:MGI:3648125] predicted gene 13772 [Source:MGI Symbol;Acc:MGI:3650155] predicted gene 5913 [Source:MGI Symbol;Acc:MGI:3648292] predicted gene 12247 [Source:MGI Symbol;Acc:MGI:3649489] predicted gene 15264 [Source:MGI Symbol;Acc:MGI:3705845] predicted gene 13680 [Source:MGI Symbol;Acc:MGI:3652285] predicted gene 15603 [Source:MGI Symbol;Acc:MGI:3783050] predicted gene 14165 [Source:MGI Symbol;Acc:MGI:3650537] predicted gene 11830 [Source:MGI Symbol;Acc:MGI:3649825] predicted gene 15821 [Source:MGI Symbol;Acc:MGI:3801940] Ccdc50 retrotransposed pseudogene [Source:MGI Symbol;Acc:MGI:3651098] predicted gene 14681 [Source:MGI Symbol;Acc:MGI:3705734] ribosomal protein, large, P0, pseudogene 1 [Source:MGI Symbol;Acc:MGI:3648599] predicted gene 15922 [Source:MGI Symbol;Acc:MGI:3802148] nucleoplasmin 3, pseudogene 1 [Source:MGI Symbol;Acc:MGI:894683] ribosomal protein S2, pseudogene 13 [Source:MGI Symbol;Acc:MGI:3705640] predicted gene 15931 [Source:MGI Symbol;Acc:MGI:3805553] transformed mouse 3T3 cell double minute 4, pseudogene [Source:MGI Symbol;Acc:MGI:2136991] predicted gene 5898 [Source:MGI Symbol;Acc:MGI:3644921] cDNA sequence BC002163 [Source:MGI Symbol;Acc:MGI:3612445] predicted gene 13245 [Source:MGI Symbol;Acc:MGI:3649656] ferritin light polypeptide 2, pseudogene [Source:MGI Symbol;Acc:MGI:95590] predicted gene 16242 [Source:MGI Symbol;Acc:MGI:3801927] DNA methyltransferase 3C [Source:MGI Symbol;Acc:MGI:3649996] predicted gene 13230 [Source:MGI Symbol;Acc:MGI:3651934] predicted gene 16464 [Source:MGI Symbol;Acc:MGI:3643716] predicted gene 14719 [Source:MGI Symbol;Acc:MGI:3705771] predicted gene 12444 [Source:MGI Symbol;Acc:MGI:3650375]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

phosphatidylserine decarboxylase, pseudogene 1 [Source:MGI Symbol;Acc:MGI:3842428] predicted gene 11425 [Source:MGI Symbol;Acc:MGI:3650957] thioredoxin peroxidase, pseudogene 1 [Source:MGI Symbol;Acc:MGI:1321403] predicted gene 13456 [Source:MGI Symbol;Acc:MGI:3651389] predicted gene 13141 [Source:MGI Symbol;Acc:MGI:3651744] predicted gene 11663 [Source:MGI Symbol;Acc:MGI:3651529] predicted gene 4875 [Source:MGI Symbol;Acc:MGI:3648108] predicted gene 5678 [Source:MGI Symbol;Acc:MGI:3646098] predicted gene 13339 [Source:MGI Symbol;Acc:MGI:3650221] predicted gene 6939 [Source:MGI Symbol;Acc:MGI:3782976] predicted gene 7658 [Source:MGI Symbol;Acc:MGI:3648029] NLR family, apoptosis inhibitory protein 3 [Source:MGI Symbol;Acc:MGI:1298225] predicted gene 11408 [Source:MGI Symbol;Acc:MGI:3651130] predicted gene 15854 [Source:MGI Symbol;Acc:MGI:3783238] predicted gene 11344 [Source:MGI Symbol;Acc:MGI:3652103] predicted gene 12187 [Source:MGI Symbol;Acc:MGI:3651944] predicted gene 16425 [Source:MGI Symbol;Acc:MGI:3643338] predicted gene 11410 [Source:MGI Symbol;Acc:MGI:3652015] predicted gene 13453 [Source:MGI Symbol;Acc:MGI:3651618] predicted gene 11839 [Source:MGI Symbol;Acc:MGI:3651162] predicted gene 11511 [Source:MGI Symbol;Acc:MGI:3649770] predicted gene 7599 [Source:MGI Symbol;Acc:MGI:3644309] LLP homolog, pseudogene 2 [Source:MGI Symbol;Acc:MGI:3642864] predicted gene 8806 [Source:MGI Symbol;Acc:MGI:3643511] predicted gene 13340 [Source:MGI Symbol;Acc:MGI:3650227] predicted gene 7224 [Source:MGI Symbol;Acc:MGI:3647435] predicted gene 14086 [Source:MGI Symbol;Acc:MGI:3649932] predicted gene 12892 [Source:MGI Symbol;Acc:MGI:3649649] predicted gene 11971 [Source:MGI Symbol;Acc:MGI:3650054] predicted gene 13123 [Source:MGI Symbol;Acc:MGI:3651473] predicted gene 13394 [Source:MGI Symbol;Acc:MGI:3651848] predicted gene 13886 [Source:MGI Symbol;Acc:MGI:3649359] predicted gene 15975 [Source:MGI Symbol;Acc:MGI:3801944] ribosomal protein S18, pseudogene 1 [Source:MGI Symbol;Acc:MGI:3650249] predicted gene 13711 [Source:MGI Symbol;Acc:MGI:3650893] predicted gene 12337 [Source:MGI Symbol;Acc:MGI:3650615] predicted gene 6733 [Source:MGI Symbol;Acc:MGI:3645402] predicted gene 11224 [Source:MGI Symbol;Acc:MGI:3651640] thymoma viral proto-oncogene 2, pseudogene [Source:MGI Symbol;Acc:MGI:108506] ribosomal protein L3, pseudogene 1 [Source:MGI Symbol;Acc:MGI:3644217] ZNF41, pseudogene [Source:MGI Symbol;Acc:MGI:1917255] predicted gene 14018 [Source:MGI Symbol;Acc:MGI:3649456] predicted gene, 22204 [Source:MGI Symbol;Acc:MGI:5451981] RIKEN cDNA 5830444B04 gene [Source:MGI Symbol;Acc:MGI:3603170] expressed sequence AI847159 [Source:MGI Symbol;Acc:MGI:3528181] predicted gene 15344 [Source:MGI Symbol;Acc:MGI:3708098] RIKEN cDNA B430010I23 gene [Source:MGI Symbol;Acc:MGI:1926099] RIKEN cDNA 1700060J05 gene [Source:MGI Symbol;Acc:MGI:1920641] predicted gene 11335 [Source:MGI Symbol;Acc:MGI:3705194] RIKEN cDNA C230035I16 gene [Source:MGI Symbol;Acc:MGI:2444850] RIKEN cDNA 4933421O10 gene [Source:MGI Symbol;Acc:MGI:1918323]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

RIKEN cDNA 4930570G19 gene [Source:MGI Symbol;Acc:MGI:1923158] RIKEN cDNA B930095G15 gene [Source:MGI Symbol;Acc:MGI:2443701] RIKEN cDNA 4933439K11 gene [Source:MGI Symbol;Acc:MGI:1918569] predicted gene 12847 [Source:MGI Symbol;Acc:MGI:3650822] predicted gene 15663 [Source:MGI Symbol;Acc:MGI:3783105] predicted gene 12336 [Source:MGI Symbol;Acc:MGI:3650722] tRNA methyltransferase 61B [Source:MGI Symbol;Acc:MGI:1916039] RIKEN cDNA 4930526A20 gene [Source:MGI Symbol;Acc:MGI:3612449] predicted gene 4969 [Source:MGI Symbol;Acc:MGI:3647482] predicted gene 11222 [Source:MGI Symbol;Acc:MGI:3651632] predicted gene 11695 [Source:MGI Symbol;Acc:MGI:3649841] predicted pseudogene 9855 [Source:MGI Symbol;Acc:MGI:3704357] predicted gene 16193 [Source:MGI Symbol;Acc:MGI:3802025] RIKEN cDNA 8430419K02 gene [Source:MGI Symbol;Acc:MGI:1921768] predicted gene 12259 [Source:MGI Symbol;Acc:MGI:3649826] RIKEN cDNA 5430402O13 gene [Source:MGI Symbol;Acc:MGI:1918631] predicted gene 15987 [Source:MGI Symbol;Acc:MGI:3801849] predicted gene 13012 [Source:MGI Symbol;Acc:MGI:3652270] potassium large conductance calcium-activated channel, subfamily M, beta member 4, opposite strand 2 [Source: predicted gene 11505 [Source:MGI Symbol;Acc:MGI:3651152] RIKEN cDNA 2610507I01 gene [Source:MGI Symbol;Acc:MGI:1919453] Rho GTPase activating protein 27, opposite strand 3 [Source:MGI Symbol;Acc:MGI:3650159] tumor necrosis factor (ligand) superfamily, member 13, opposite strand [Source:MGI Symbol;Acc:MGI:1919587] predicted gene 13032 [Source:MGI Symbol;Acc:MGI:3702685] RIKEN cDNA 2610307P16 gene [Source:MGI Symbol;Acc:MGI:1919768] predicted gene 2788 [Source:MGI Symbol;Acc:MGI:3780956] predicted gene 15318 [Source:MGI Symbol;Acc:MGI:3705106] predicted gene 15706 [Source:MGI Symbol;Acc:MGI:3783146] WAS/WASL interacting protein family, member 3 [Source:MGI Symbol;Acc:MGI:3044681] natural cytotoxicity triggering receptor 3, pseudogene [Source:MGI Symbol;Acc:MGI:2149332] predicted gene 15326 [Source:MGI Symbol;Acc:MGI:3705205] predicted gene 16342 [Source:MGI Symbol;Acc:MGI:3840138] predicted gene 15513 [Source:MGI Symbol;Acc:MGI:3782961] RIKEN cDNA B230369F24 gene [Source:MGI Symbol;Acc:MGI:2443392] predicted gene 13481 [Source:MGI Symbol;Acc:MGI:3651624] RIKEN cDNA 1810019D21 gene [Source:MGI Symbol;Acc:MGI:1917021] RIKEN cDNA A630014C17 gene [Source:MGI Symbol;Acc:MGI:3026989] protein kinase, AMP-activated, gamma 2 non-catalytic subunit, opposite strand 1 [Source:MGI Symbol;Acc:MGI: RIKEN cDNA 1700030C12 gene [Source:MGI Symbol;Acc:MGI:1919496] Ewing tumor-associated antigen 1, opposite strand [Source:MGI Symbol;Acc:MGI:1920221] predicted gene 16172 [Source:MGI Symbol;Acc:MGI:3801735] predicted gene 13778 [Source:MGI Symbol;Acc:MGI:3649233] RIKEN cDNA 9130208D14 gene [Source:MGI Symbol;Acc:MGI:1924950] predicted gene, 16758 [Source:MGI Symbol;Acc:MGI:4439682] RIKEN cDNA C030005K06 gene [Source:MGI Symbol;Acc:MGI:1925945] RIKEN cDNA 2810403D21 gene [Source:MGI Symbol;Acc:MGI:1917214] predicted gene 14029 [Source:MGI Symbol;Acc:MGI:3650450] predicted gene 15247 [Source:MGI Symbol;Acc:MGI:3705183] expressed sequence AI427809 [Source:MGI Symbol;Acc:MGI:2140270] predicted gene 11770 [Source:MGI Symbol;Acc:MGI:3651450] plexin A4, opposite strand 1 [Source:MGI Symbol;Acc:MGI:2442851]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

predicted gene 11827 [Source:MGI Symbol;Acc:MGI:3649801] predicted gene 11579 [Source:MGI Symbol;Acc:MGI:3650510] predicted gene 16225 [Source:MGI Symbol;Acc:MGI:3801903] RIKEN cDNA 4930429F24 gene [Source:MGI Symbol;Acc:MGI:1921883] RIKEN cDNA 4930481A15 gene [Source:MGI Symbol;Acc:MGI:1922181] predicted gene 12248 [Source:MGI Symbol;Acc:MGI:3651124] predicted gene 14154 [Source:MGI Symbol;Acc:MGI:3649354] predicted gene 5530 [Source:MGI Symbol;Acc:MGI:3646374] predicted gene 12405 [Source:MGI Symbol;Acc:MGI:3649392] predicted gene 14022 [Source:MGI Symbol;Acc:MGI:3649977] predicted gene 6483 [Source:MGI Symbol;Acc:MGI:3644574] predicted gene 12827 [Source:MGI Symbol;Acc:MGI:3651358] predicted gene 13346 [Source:MGI Symbol;Acc:MGI:3649698] RIKEN cDNA 2610035D17 gene [Source:MGI Symbol;Acc:MGI:1919636] predicted gene 13203 [Source:MGI Symbol;Acc:MGI:3651445] RIKEN cDNA 2010013B24 gene [Source:MGI Symbol;Acc:MGI:1919329] RIKEN cDNA 4930544D05 gene [Source:MGI Symbol;Acc:MGI:2148639] predicted gene 13832 [Source:MGI Symbol;Acc:MGI:3650708] lipase, member O2 [Source:MGI Symbol;Acc:MGI:3644466] RIKEN cDNA A430035B10 gene [Source:MGI Symbol;Acc:MGI:2443789] RIKEN cDNA 1700047K16 gene [Source:MGI Symbol;Acc:MGI:1920585] predicted gene 13710 [Source:MGI Symbol;Acc:MGI:3650894] predicted gene 11998 [Source:MGI Symbol;Acc:MGI:3650897] predicted gene 16091 [Source:MGI Symbol;Acc:MGI:3802007] predicted gene 15533 [Source:MGI Symbol;Acc:MGI:3782982] pluripotency associated transcript 27 [Source:MGI Symbol;Acc:MGI:1925566] RIKEN cDNA C030037D09 gene [Source:MGI Symbol;Acc:MGI:1924865] immunoglobulin heavy variable V6-7 [Source:MGI Symbol;Acc:MGI:3644477] erythrocyte membrane protein band 4.1 like 4a, opposite strand [Source:MGI Symbol;Acc:MGI:1916999] RIKEN cDNA A230059L01 gene [Source:MGI Symbol;Acc:MGI:2443688] predicted gene 14455 [Source:MGI Symbol;Acc:MGI:3711286] RIKEN cDNA 1500009L16 gene [Source:MGI Symbol;Acc:MGI:1917034] predicted gene 15674 [Source:MGI Symbol;Acc:MGI:3783116] microRNA 1943 [Source:MGI Symbol;Acc:MGI:3836982] predicted gene, 23823 [Source:MGI Symbol;Acc:MGI:5453600] UDP glucuronosyltransferase 1 family, polypeptide A8 [Source:MGI Symbol;Acc:MGI:3576090] alanine-glyoxylate aminotransferase 2 [Source:MGI Symbol;Acc:MGI:2146052] predicted gene 16299 [Source:MGI Symbol;Acc:MGI:3826539] predicted gene 2343 [Source:MGI Symbol;Acc:MGI:3780513] RIKEN cDNA 2310075C17 gene [Source:MGI Symbol;Acc:MGI:1917444] killer cell lectin-like receptor, subfamily A, member 8 [Source:MGI Symbol;Acc:MGI:102968] predicted gene 8428 [Source:MGI Symbol;Acc:MGI:3648643] thymosin beta 15b1 [Source:MGI Symbol;Acc:MGI:3843059] predicted gene 8113 [Source:MGI Symbol;Acc:MGI:3648791] B cell leukemia/lymphoma 2 related protein A1b [Source:MGI Symbol;Acc:MGI:1278326] F-box protein 24 [Source:MGI Symbol;Acc:MGI:1918426] Riken cDNA 1810020O05 gene [Source:MGI Symbol;Acc:MGI:3586838] predicted gene 16251 [Source:MGI Symbol;Acc:MGI:3826569] ALMS1, centrosome and basal body associated, pseudogene 2 [Source:MGI Symbol;Acc:MGI:3779593] predicted gene 15890 [Source:MGI Symbol;Acc:MGI:3802160] ubiquitin A-52 residue ribosomal protein fusion 1 [Source:MGI Symbol;Acc:MGI:98887]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

eosinophil-associated, ribonuclease A family, member 10 [Source:MGI Symbol;Acc:MGI:1890464] Cd200 receptor 2 [Source:MGI Symbol;Acc:MGI:3042847] tripartite motif-containing 34B [Source:MGI Symbol;Acc:MGI:4821264] interferon activated gene 203, pseudogene [Source:MGI Symbol;Acc:MGI:3840117] methyltransferase like 23 [Source:MGI Symbol;Acc:MGI:1921569] myeloid nuclear differentiation antigen like [Source:MGI Symbol;Acc:MGI:3780953] predicted gene, 38399 [Source:MGI Symbol;Acc:MGI:5620007] ribosomal protein S11, pseudogene 1 [Source:MGI Symbol;Acc:MGI:3644744] small nuclear ribonucleoprotein E [Source:MGI Symbol;Acc:MGI:98346] predicted gene 17207 [Source:MGI Symbol;Acc:MGI:4938034] RIKEN cDNA A930033H14 gene [Source:MGI Symbol;Acc:MGI:2444562] DNA segment, Chr 6, ERATO Doi 527, expressed [Source:MGI Symbol;Acc:MGI:1261919] predicted gene, 17251 [Source:MGI Symbol;Acc:MGI:4936885] predicted gene 5828 [Source:MGI Symbol;Acc:MGI:3644176] predicted gene 3248 [Source:MGI Symbol;Acc:MGI:3781426] collagen, type VI, alpha 5 [Source:MGI Symbol;Acc:MGI:3648134] predicted gene 8810 [Source:MGI Symbol;Acc:MGI:3779814] histone cluster 1, H2al [Source:MGI Symbol;Acc:MGI:3646032] histone cluster 2, H4 [Source:MGI Symbol;Acc:MGI:2140113] predicted gene 6728 [Source:MGI Symbol;Acc:MGI:3643418] predicted gene 3739 [Source:MGI Symbol;Acc:MGI:3781914] catsper channel auxiliary subunit epsilon 2 [Source:MGI Symbol;Acc:MGI:5589632] vomeronasal 2, receptor 97 [Source:MGI Symbol;Acc:MGI:3645271] translational machinery associated 7 [Source:MGI Symbol;Acc:MGI:1913417] predicted gene 6548 [Source:MGI Symbol;Acc:MGI:3644071] RIKEN cDNA 2010016I18 gene [Source:MGI Symbol;Acc:MGI:1916456] immunoglobulin heavy variable 2-1 [Source:MGI Symbol;Acc:MGI:4936981] vomeronasal 2, receptor 96 [Source:MGI Symbol;Acc:MGI:3644514] eukaryotic translation initiation factor 3, subunit 6, pseudogene 2 [Source:MGI Symbol;Acc:MGI:103204] histocompatibility 2, Q region locus 2 [Source:MGI Symbol;Acc:MGI:95931] SEC14-like lipid binding 5 [Source:MGI Symbol;Acc:MGI:3616084] predicted gene 3636 [Source:MGI Symbol;Acc:MGI:3781812] immunoglobulin kappa variable 1-115 [Source:MGI Symbol;Acc:MGI:3644873] predicted gene 6257 [Source:MGI Symbol;Acc:MGI:3645370] potassium voltage gated channel, Shab-related subfamily, member 2 [Source:MGI Symbol;Acc:MGI:99632] predicted gene 5819 [Source:MGI Symbol;Acc:MGI:3643122] predicted gene 3696 [Source:MGI Symbol;Acc:MGI:3781872] RIKEN cDNA 4930515G01 gene [Source:MGI Symbol;Acc:MGI:1914892] serine/threonine kinase 19, pseudogene 1 [Source:MGI Symbol;Acc:MGI:2148500] predicted gene, 19345 [Source:MGI Symbol;Acc:MGI:5011530] predicted gene 20506 [Source:MGI Symbol;Acc:MGI:5141971] histocompatibility 2, Q region locus 3 [Source:MGI Symbol;Acc:MGI:95932] predicted gene 20519 [Source:MGI Symbol;Acc:MGI:5141984] predicted gene 5682 [Source:MGI Symbol;Acc:MGI:3647684] predicted pseudogene 8752 [Source:MGI Symbol;Acc:MGI:3647539] predicted gene 6659 [Source:MGI Symbol;Acc:MGI:3648914] phosphoribosyl pyrophosphate synthetase 1-like 1 [Source:MGI Symbol;Acc:MGI:1922706] zinc finger protein 977 [Source:MGI Symbol;Acc:MGI:3645327] metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) [Source:MGI Symbol;Acc:MGI:191953 pluripotency associated transcript 17 [Source:MGI Symbol;Acc:MGI:3054967] predicted gene 20485 [Source:MGI Symbol;Acc:MGI:5141950]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

zinc finger protein 141 [Source:MGI Symbol;Acc:MGI:3584269] predicted gene, 18734 [Source:MGI Symbol;Acc:MGI:5010919] predicted gene, 18733 [Source:MGI Symbol;Acc:MGI:5010918] predicted gene 8835 [Source:MGI Symbol;Acc:MGI:3646857] cDNA sequence BC051226 [Source:MGI Symbol;Acc:MGI:3039585] predicted gene 20429 [Source:MGI Symbol;Acc:MGI:5141894] predicted gene 20490 [Source:MGI Symbol;Acc:MGI:5141955] sodium channel modifier 1 [Source:MGI Symbol;Acc:MGI:1341284] predicted gene 20621 [Source:MGI Symbol;Acc:MGI:5313068] leucine-rich repeats and calponin homology (CH) domain containing 4 [Source:MGI Symbol;Acc:MGI:1917193] expressed sequence AA465934 [Source:MGI Symbol;Acc:MGI:2671018] predicted gene 20705 [Source:MGI Symbol;Acc:MGI:5313152] RAB26, member RAS oncogene family, opposite strand [Source:MGI Symbol;Acc:MGI:1922864] immunoglobulin kappa variable 1-110 [Source:MGI Symbol;Acc:MGI:4439558] transmembrane protein 181C, pseudogene [Source:MGI Symbol;Acc:MGI:3780993] immunoglobulin heavy variable 1-53 [Source:MGI Symbol;Acc:MGI:3576502] immunoglobulin heavy variable 1-76 [Source:MGI Symbol;Acc:MGI:4439737] immunoglobulin kappa variable 9-129 [Source:MGI Symbol;Acc:MGI:3525017] immunoglobulin heavy variable 1-34 [Source:MGI Symbol;Acc:MGI:4439659] predicted gene 2237 [Source:MGI Symbol;Acc:MGI:3780407] immunoglobulin kappa variable 4-59 [Source:MGI Symbol;Acc:MGI:3646808] T cell receptor alpha variable 15-1-DV6-1 [Source:MGI Symbol;Acc:MGI:4439369] immunoglobulin heavy variable V3-3 [Source:MGI Symbol;Acc:MGI:3643949] immunoglobulin heavy variable 1-80 [Source:MGI Symbol;Acc:MGI:4439738] immunoglobulin heavy variable 1-64 [Source:MGI Symbol;Acc:MGI:4439789] predicted gene, 21885 [Source:MGI Symbol;Acc:MGI:5434049] immunoglobulin kappa chain variable 5-45 [Source:MGI Symbol;Acc:MGI:4439774] immunoglobulin heavy variable V9-2 [Source:MGI Symbol;Acc:MGI:3643816] immunoglobulin kappa variable 3-12 [Source:MGI Symbol;Acc:MGI:1330815] immunoglobulin heavy variable V1-74 [Source:MGI Symbol;Acc:MGI:4439634] solute carrier family 6, member 16 [Source:MGI Symbol;Acc:MGI:2685930] immunoglobulin heavy variable 2-3 [Source:MGI Symbol;Acc:MGI:4439872] immunoglobulin heavy variable 5-16 [Source:MGI Symbol;Acc:MGI:4439556] immunoglobulin heavy variable 1-50 [Source:MGI Symbol;Acc:MGI:4439753] adaptor-related protein complex 3, sigma 1 subunit, pseudogene 2 [Source:MGI Symbol;Acc:MGI:1929217] immunoglobulin kappa variable 4-78 [Source:MGI Symbol;Acc:MGI:3819775] immunoglobulin kappa chain variable 4-54 [Source:MGI Symbol;Acc:MGI:5009821] immunoglobulin heavy variable 9-4 [Source:MGI Symbol;Acc:MGI:3646379] immunoglobulin kappa variable 1-117 [Source:MGI Symbol;Acc:MGI:4439721] predicted gene 11942 [Source:MGI Symbol;Acc:MGI:3650608] immunoglobulin kappa variable 8-28 [Source:MGI Symbol;Acc:MGI:3642251] immunoglobulin kappa chain variable 5-43 [Source:MGI Symbol;Acc:MGI:4943320] RIKEN cDNA 9430069I07 gene [Source:MGI Symbol;Acc:MGI:1924608] immunoglobulin kappa variable 1-133 [Source:MGI Symbol;Acc:MGI:3648380] predicted pseudogene 8210 [Source:MGI Symbol;Acc:MGI:3643593] predicted gene, 21399 [Source:MGI Symbol;Acc:MGI:5434754] immunoglobulin heavy variable 11-1 [Source:MGI Symbol;Acc:MGI:4439535] predicted gene 3468 [Source:MGI Symbol;Acc:MGI:3781644] predicted gene 7102 [Source:MGI Symbol;Acc:MGI:3648735] immunoglobulin heavy variable V1-42 [Source:MGI Symbol;Acc:MGI:3704123] predicted pseudogene 5900 [Source:MGI Symbol;Acc:MGI:3643907]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

immunoglobulin heavy variable V1-9 [Source:MGI Symbol;Acc:MGI:4439621] immunoglobulin kappa variable 6-15 [Source:MGI Symbol;Acc:MGI:1330831] T cell receptor alpha variable 3-3 [Source:MGI Symbol;Acc:MGI:3702145] immunoglobulin heavy variable 1-56 [Source:MGI Symbol;Acc:MGI:4439715] immunoglobulin kappa chain variable 9-120 [Source:MGI Symbol;Acc:MGI:3647784] RIKEN cDNA D430019H16 gene [Source:MGI Symbol;Acc:MGI:2443127] immunoglobulin kappa chain variable 6-25 [Source:MGI Symbol;Acc:MGI:4439867] immunoglobulin heavy variable 1-84 [Source:MGI Symbol;Acc:MGI:3644235] predicted gene 3604 [Source:MGI Symbol;Acc:MGI:3781781] immunoglobulin heavy variable 5-6 [Source:MGI Symbol;Acc:MGI:4439815] immunoglobulin kappa chain variable 4-51 [Source:MGI Symbol;Acc:MGI:5009829] immunoglobulin kappa chain variable 12-41 [Source:MGI Symbol;Acc:MGI:4439772] predicted gene 13146 [Source:MGI Symbol;Acc:MGI:3651742] immunoglobulin heavy variable 1-82 [Source:MGI Symbol;Acc:MGI:4439671] immunoglobulin heavy variable V8-11 [Source:MGI Symbol;Acc:MGI:3644925] predicted gene, 20069 [Source:MGI Symbol;Acc:MGI:5012254] immunoglobulin heavy variable V1-7 [Source:MGI Symbol;Acc:MGI:3704122] immunoglobulin heavy variable 1-52 [Source:MGI Symbol;Acc:MGI:4439752] immunoglobulin heavy variable 5-9 [Source:MGI Symbol;Acc:MGI:4439873] immunoglobulin kappa chain variable 3-5 [Source:MGI Symbol;Acc:MGI:1330854] immunoglobulin kappa variable 3-9 [Source:MGI Symbol;Acc:MGI:1330856] immunoglobulin kappa variable 3-2 [Source:MGI Symbol;Acc:MGI:1330850] predicted gene, 21092 [Source:MGI Symbol;Acc:MGI:5434447] immunoglobulin heavy variable V1-12 [Source:MGI Symbol;Acc:MGI:3646284] immunoglobulin heavy variable 5-12 [Source:MGI Symbol;Acc:MGI:4439516] fidgetin-like 2 [Source:MGI Symbol;Acc:MGI:3646919] immunoglobulin heavy variable 1-4 [Source:MGI Symbol;Acc:MGI:4439618] immunoglobulin kappa chain variable 1-122 [Source:MGI Symbol;Acc:MGI:4439722] immunoglobulin heavy variable 1-66 [Source:MGI Symbol;Acc:MGI:4439825] immunoglobulin heavy variable 2-9-1 [Source:MGI Symbol;Acc:MGI:4439519] immunoglobulin heavy variable 5-17 [Source:MGI Symbol;Acc:MGI:4439533] immunoglobulin heavy variable 14-2 [Source:MGI Symbol;Acc:MGI:4439607] predicted pseudogene 6472 [Source:MGI Symbol;Acc:MGI:3648396] immunoglobulin heavy variable 5-4 [Source:MGI Symbol;Acc:MGI:4439895] immunoglobulin kappa variable 6-23 [Source:MGI Symbol;Acc:MGI:3711980] immunoglobulin heavy variable V14-3 [Source:MGI Symbol;Acc:MGI:4439764] predicted pseudogene 8935 [Source:MGI Symbol;Acc:MGI:3643401] T cell receptor beta, D region 1 [Source:MGI Symbol;Acc:MGI:4439571] immunoglobulin kappa variable 3-1 [Source:MGI Symbol;Acc:MGI:1330851] immunoglobulin heavy variable V10-3 [Source:MGI Symbol;Acc:MGI:3648785] immunoglobulin kappa variable 11-125 [Source:MGI Symbol;Acc:MGI:3642338] immunoglobulin kappa variable 4-53 [Source:MGI Symbol;Acc:MGI:2686266] immunoglobulin heavy variable V1-20 [Source:MGI Symbol;Acc:MGI:3644607] immunoglobulin kappa variable 14-111 [Source:MGI Symbol;Acc:MGI:4439863] immunoglobulin kappa variable 6-17 [Source:MGI Symbol;Acc:MGI:1330833] immunoglobulin heavy variable V1-43 [Source:MGI Symbol;Acc:MGI:3704124] immunoglobulin heavy variable V2-4 [Source:MGI Symbol;Acc:MGI:3643263] immunoglobulin heavy variable 1-37 [Source:MGI Symbol;Acc:MGI:4439640] NIM1 serine/threonine protein kinase [Source:MGI Symbol;Acc:MGI:2442399] immunoglobulin heavy variable 10-1 [Source:MGI Symbol;Acc:MGI:4439620] immunoglobulin heavy variable 1-75 [Source:MGI Symbol;Acc:MGI:4439735]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

immunoglobulin heavy variable 1-72 [Source:MGI Symbol;Acc:MGI:4439633] immunoglobulin heavy variable 1-62-2 [Source:MGI Symbol;Acc:MGI:3644968] immunoglobulin heavy variable 1-85 [Source:MGI Symbol;Acc:MGI:3645723] predicted gene 5472 [Source:MGI Symbol;Acc:MGI:3648309] T cell receptor delta diversity 2 [Source:MGI Symbol;Acc:MGI:4439546] predicted gene 13238 [Source:MGI Symbol;Acc:MGI:3652104] dynein light chain Tctex-type 1B [Source:MGI Symbol;Acc:MGI:98643] immunoglobulin heavy variable 1-78 [Source:MGI Symbol;Acc:MGI:4439736] immunoglobulin kappa variable 1-135 [Source:MGI Symbol;Acc:MGI:3819952] predicted gene 9825 [Source:MGI Symbol;Acc:MGI:3708729] immunoglobulin heavy variable V6-5 [Source:MGI Symbol;Acc:MGI:3647134] immunoglobulin heavy variable V1-19 [Source:MGI Symbol;Acc:MGI:4439779] predicted gene 4076 [Source:MGI Symbol;Acc:MGI:3782251] immunoglobulin heavy variable 1-77 [Source:MGI Symbol;Acc:MGI:4439670] immunoglobulin heavy variable V9-3 [Source:MGI Symbol;Acc:MGI:3642720] immunoglobulin kappa variable 14-130 [Source:MGI Symbol;Acc:MGI:3645770] immunoglobulin heavy variable 2-2 [Source:MGI Symbol;Acc:MGI:4439894] predicted gene, 23977 [Source:MGI Symbol;Acc:MGI:5453754] immunoglobulin kappa variable 10-94 [Source:MGI Symbol;Acc:MGI:3646140] immunoglobulin heavy variable 2-5 [Source:MGI Symbol;Acc:MGI:4439517] immunoglobulin heavy variable V1-5 [Source:MGI Symbol;Acc:MGI:3704121] immunoglobulin kappa chain variable 14-100 [Source:MGI Symbol;Acc:MGI:4439559] immunoglobulin kappa variable 1-132 [Source:MGI Symbol;Acc:MGI:3648800] immunoglobulin kappa variable 8-19 [Source:MGI Symbol;Acc:MGI:1330844] predicted gene 3383 [Source:MGI Symbol;Acc:MGI:3781561] immunoglobulin kappa chain variable 9-124 [Source:MGI Symbol;Acc:MGI:3646892] immunoglobulin heavy variable 2-9 [Source:MGI Symbol;Acc:MGI:4439624] immunoglobulin heavy variable 2-6 [Source:MGI Symbol;Acc:MGI:4439518] immunoglobulin heavy variable V1-63 [Source:MGI Symbol;Acc:MGI:3642755] zinc finger protein 960 [Source:MGI Symbol;Acc:MGI:3052731] ferritin light polypeptide, pseudogene 2 [Source:MGI Symbol;Acc:MGI:5434102] immunoglobulin heavy variable 1-62-3 [Source:MGI Symbol;Acc:MGI:3648544] transmembrane protein 181B, pseudogene [Source:MGI Symbol;Acc:MGI:3779544] immunoglobulin heavy variable 2-7 [Source:MGI Symbol;Acc:MGI:4439521] immunoglobulin kappa variable 4-55 [Source:MGI Symbol;Acc:MGI:2686370] shisa family member 8 [Source:MGI Symbol;Acc:MGI:2146080] RIKEN cDNA E230013L22 gene [Source:MGI Symbol;Acc:MGI:2142601] predicted gene, 26880 [Source:MGI Symbol;Acc:MGI:5477374] RIKEN cDNA 1700086O06 gene [Source:MGI Symbol;Acc:MGI:1920766] predicted gene, 19705 [Source:MGI Symbol;Acc:MGI:5011890] predicted gene, 26511 [Source:MGI Symbol;Acc:MGI:5477005] RIKEN cDNA 9330159M07 gene [Source:MGI Symbol;Acc:MGI:2442519] predicted gene, 26664 [Source:MGI Symbol;Acc:MGI:5477158] predicted gene, 26853 [Source:MGI Symbol;Acc:MGI:5477347] predicted gene, 16907 [Source:MGI Symbol;Acc:MGI:4439831] predicted gene 6634 [Source:MGI Symbol;Acc:MGI:3643829] RIKEN cDNA 4930532G15 gene [Source:MGI Symbol;Acc:MGI:1922432] RIKEN cDNA 4930525G20 gene [Source:MGI Symbol;Acc:MGI:2443505] RIKEN cDNA 2010300F17 gene [Source:MGI Symbol;Acc:MGI:1917134] high mobility group box 1, pseudogene 8 [Source:MGI Symbol;Acc:MGI:96114] RIKEN cDNA 9130213A22 gene [Source:MGI Symbol;Acc:MGI:3642718]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

predicted gene 10814 [Source:MGI Symbol;Acc:MGI:3642580] predicted gene, 26669 [Source:MGI Symbol;Acc:MGI:5477163] predicted gene, 26782 [Source:MGI Symbol;Acc:MGI:5477276] predicted gene, 17529 [Source:MGI Symbol;Acc:MGI:4937163] RNA imprinted and accumulated in nucleus [Source:MGI Symbol;Acc:MGI:1922995] predicted gene, 26586 [Source:MGI Symbol;Acc:MGI:5477080] predicted gene, 26583 [Source:MGI Symbol;Acc:MGI:5477077] predicted gene, 26808 [Source:MGI Symbol;Acc:MGI:5477302] predicted gene, 26750 [Source:MGI Symbol;Acc:MGI:5477244] predicted gene, 26825 [Source:MGI Symbol;Acc:MGI:5477319] predicted gene, 26637 [Source:MGI Symbol;Acc:MGI:5477131] predicted gene, 26797 [Source:MGI Symbol;Acc:MGI:5477291] RIKEN cDNA C920006O11 gene [Source:MGI Symbol;Acc:MGI:2443759] RIKEN cDNA 1700125G22 gene [Source:MGI Symbol;Acc:MGI:1923907] RIKEN cDNA 1110019D14 gene [Source:MGI Symbol;Acc:MGI:1923561] RIKEN cDNA A130051J0 gene [Source:MGI Symbol;Acc:MGI:3642574] predicted gene, 26862 [Source:MGI Symbol;Acc:MGI:5477356] predicted gene 2093 [Source:MGI Symbol;Acc:MGI:3780260] predicted gene, 26740 [Source:MGI Symbol;Acc:MGI:5477234] predicted gene 7741 [Source:MGI Symbol;Acc:MGI:3647088] RIKEN cDNA B230217O12 gene [Source:MGI Symbol;Acc:MGI:2444948] predicted gene, 26812 [Source:MGI Symbol;Acc:MGI:5477306] predicted gene, 26681 [Source:MGI Symbol;Acc:MGI:5477175] RIKEN cDNA 9630001P10 gene [Source:MGI Symbol;Acc:MGI:2441755] predicted gene, 26857 [Source:MGI Symbol;Acc:MGI:5477351] RIKEN cDNA 1010001B22 gene [Source:MGI Symbol;Acc:MGI:1922653] GSG1-like 2 [Source:MGI Symbol;Acc:MGI:3650209] predicted gene 3650 [Source:MGI Symbol;Acc:MGI:3781826] predicted gene, 26531 [Source:MGI Symbol;Acc:MGI:5477025] predicted gene 9625 [Source:MGI Symbol;Acc:MGI:3780033] RIKEN cDNA 4933404O12 gene [Source:MGI Symbol;Acc:MGI:1914002] RIKEN cDNA A730020E08 gene [Source:MGI Symbol;Acc:MGI:2444999] RIKEN cDNA A330074K22 gene [Source:MGI Symbol;Acc:MGI:3045392] predicted gene, 19557 [Source:MGI Symbol;Acc:MGI:5011742] protein tyrosine phosphatase, receptor type, V [Source:MGI Symbol;Acc:MGI:108027] predicted gene, 27026 [Source:MGI Symbol;Acc:MGI:5504141] predicted gene 9522 [Source:MGI Symbol;Acc:MGI:3779931] zinc finger protein 82 [Source:MGI Symbol;Acc:MGI:1890753] RIKEN cDNA 2700099C18 gene [Source:MGI Symbol;Acc:MGI:1924272] sosondowah ankyrin repeat domain family member C [Source:MGI Symbol;Acc:MGI:3606051] cDNA sequence BC051537 [Source:MGI Symbol;Acc:MGI:3041255] histocompatibility 2, P region alpha locus [Source:MGI Symbol;Acc:MGI:105314] lncRNA downstream of Cdkn1b [Source:MGI Symbol;Acc:MGI:1915081] RIKEN cDNA 5830468F06 gene [Source:MGI Symbol;Acc:MGI:1923332] predicted gene 27217 [Source:MGI Symbol;Acc:MGI:5521060] immunoglobulin kappa chain variable 19-93 [Source:MGI Symbol;Acc:MGI:107617] predicted gene, 18190 [Source:MGI Symbol;Acc:MGI:5010375] predicted gene, 18853 [Source:MGI Symbol;Acc:MGI:5011038] transcription factor 24 [Source:MGI Symbol;Acc:MGI:3780500] oocyte specific homeobox 8 [Source:MGI Symbol;Acc:MGI:3645855] predicted gene, 18180 [Source:MGI Symbol;Acc:MGI:5010365]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

predicted gene 7809 [Source:MGI Symbol;Acc:MGI:3643362] predicted gene 29340 [Source:MGI Symbol;Acc:MGI:5580046] RIKEN cDNA 2310034G01 gene [Source:MGI Symbol;Acc:MGI:1922829] predicted gene 28285 [Source:MGI Symbol;Acc:MGI:5578991] RIKEN cDNA 1700030C10 gene [Source:MGI Symbol;Acc:MGI:1916763] predicted gene 28884 [Source:MGI Symbol;Acc:MGI:5579590] predicted gene 5960 [Source:MGI Symbol;Acc:MGI:3779540] RIKEN cDNA 1700029J03 gene [Source:MGI Symbol;Acc:MGI:1919514] predicted gene, 19585 [Source:MGI Symbol;Acc:MGI:5011770] RIKEN cDNA 1810006J02 gene [Source:MGI Symbol;Acc:MGI:1916280] predicted gene 8292 [Source:MGI Symbol;Acc:MGI:3648460] predicted gene 28557 [Source:MGI Symbol;Acc:MGI:5579263] RIKEN cDNA 1810053B23 gene [Source:MGI Symbol;Acc:MGI:1917107] predicted gene 28455 [Source:MGI Symbol;Acc:MGI:5579161] RIKEN cDNA 2810414N06 gene [Source:MGI Symbol;Acc:MGI:1919065] predicted gene 28277 [Source:MGI Symbol;Acc:MGI:5578983] RIKEN cDNA F730311O21 gene [Source:MGI Symbol;Acc:MGI:3643355] RIKEN cDNA 1810044D09 gene [Source:MGI Symbol;Acc:MGI:1917048] predicted gene 12663 [Source:MGI Symbol;Acc:MGI:3652168] predicted gene 29183 [Source:MGI Symbol;Acc:MGI:5579889] membrane-spanning 4-domains, subfamily A, member 4A [Source:MGI Symbol;Acc:MGI:3643932] predicted gene 29163 [Source:MGI Symbol;Acc:MGI:5579869] predicted gene 7901 [Source:MGI Symbol;Acc:MGI:3645047] predicted gene 3052 [Source:MGI Symbol;Acc:MGI:3781230] predicted pseudogene 10031 [Source:MGI Symbol;Acc:MGI:3704198] predicted gene 5733 [Source:MGI Symbol;Acc:MGI:3642992] predicted gene 28438 [Source:MGI Symbol;Acc:MGI:5579144] B cell leukemia/lymphoma 2 related protein A1a [Source:MGI Symbol;Acc:MGI:102687] predicted gene 2367 [Source:MGI Symbol;Acc:MGI:3780535] RIKEN cDNA 9430037O13 gene [Source:MGI Symbol;Acc:MGI:1924535] small nuclear ribonucleoprotein N [Source:MGI Symbol;Acc:MGI:98347] predicted gene, 37144 [Source:MGI Symbol;Acc:MGI:5610372] predicted gene, 37145 [Source:MGI Symbol;Acc:MGI:5610373] immunoglobulin heavy variable 1-30 [Source:MGI Symbol;Acc:MGI:4937173] predicted gene, 37004 [Source:MGI Symbol;Acc:MGI:5610232] immunoglobulin heavy variable V8-2 [Source:MGI Symbol;Acc:MGI:3647474] immunoglobulin heavy variable 1-28 [Source:MGI Symbol;Acc:MGI:3644938] immunoglobulin heavy variable V8-5 [Source:MGI Symbol;Acc:MGI:3645478] SH2 domain containing 1B1 [Source:MGI Symbol;Acc:MGI:1349420] predicted gene, 37166 [Source:MGI Symbol;Acc:MGI:5610394] cation channel sperm associated auxiliary subunit epsilon 1 [Source:MGI Symbol;Acc:MGI:3647531] predicted gene 8010 [Source:MGI Symbol;Acc:MGI:3648648] immunoglobulin heavy variable V1-29 [Source:MGI Symbol;Acc:MGI:5009909] protocadherin gamma subfamily C, 5 [Source:MGI Symbol;Acc:MGI:1935205] predicted gene 5103 [Source:MGI Symbol;Acc:MGI:3779459] immunoglobulin heavy variable V1-21 [Source:MGI Symbol;Acc:MGI:5009841] immunoglobulin heavy variable V1-32 [Source:MGI Symbol;Acc:MGI:5009910] immunoglobulin heavy variable 1-21-1 [Source:MGI Symbol;Acc:MGI:3645737] predicted gene, 37759 [Source:MGI Symbol;Acc:MGI:5610987] predicted gene 7694 [Source:MGI Symbol;Acc:MGI:3649135] immunoglobulin heavy variable V1-62 [Source:MGI Symbol;Acc:MGI:5009844]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

predicted gene, 38253 [Source:MGI Symbol;Acc:MGI:5611481] programmed cell death 5, pseudogene [Source:MGI Symbol;Acc:MGI:3782009] predicted gene 9694 [Source:MGI Symbol;Acc:MGI:3780102] predicted gene 2065 [Source:MGI Symbol;Acc:MGI:3780232] immunoglobulin heavy variable V5-1 [Source:MGI Symbol;Acc:MGI:5009886] predicted gene, 31728 [Source:MGI Symbol;Acc:MGI:5590887] immunoglobulin heavy variable 1-33 [Source:MGI Symbol;Acc:MGI:4439617] immunoglobulin heavy variable 1-25 [Source:MGI Symbol;Acc:MGI:3648295] immunoglobulin heavy variable V1-40 [Source:MGI Symbol;Acc:MGI:5009912] predicted gene, 37121 [Source:MGI Symbol;Acc:MGI:5610349] immunoglobulin heavy variable 5-12-4 [Source:MGI Symbol;Acc:MGI:3645977] protocadherin gamma subfamily B, 6 [Source:MGI Symbol;Acc:MGI:1935197] predicted gene, 37387 [Source:MGI Symbol;Acc:MGI:5610615] predicted gene, 38150 [Source:MGI Symbol;Acc:MGI:5611378] predicted gene, 30948 [Source:MGI Symbol;Acc:MGI:5590107] predicted gene, 37170 [Source:MGI Symbol;Acc:MGI:5610398] predicted gene, 37169 [Source:MGI Symbol;Acc:MGI:5610397] predicted gene 8146 [Source:MGI Symbol;Acc:MGI:3644273] immunoglobulin heavy variable V4-2 [Source:MGI Symbol;Acc:MGI:5009840] immunoglobulin heavy variable V1-23 [Source:MGI Symbol;Acc:MGI:3815050] immunoglobulin heavy variable 3-2 [Source:MGI Symbol;Acc:MGI:4439923] predicted gene 7804 [Source:MGI Symbol;Acc:MGI:3643373] immunoglobulin heavy variable V1-27 [Source:MGI Symbol;Acc:MGI:5009908] leucine-rich single-pass membrane protein 2 [Source:MGI Symbol;Acc:MGI:3612240] RIKEN cDNA 1700008A23 gene [Source:MGI Symbol;Acc:MGI:1922713] predicted gene, 37261 [Source:MGI Symbol;Acc:MGI:5610489] predicted gene, 37668 [Source:MGI Symbol;Acc:MGI:5610896] predicted gene, 37669 [Source:MGI Symbol;Acc:MGI:5610897] RIKEN cDNA 5830405F06 gene [Source:MGI Symbol;Acc:MGI:1923265] predicted gene, 18445 [Source:MGI Symbol;Acc:MGI:5010630] predicted gene, 37352 [Source:MGI Symbol;Acc:MGI:5610580] RIKEN cDNA 6820402A03 gene [Source:MGI Symbol;Acc:MGI:1922992] predicted gene, 37527 [Source:MGI Symbol;Acc:MGI:5610755] immunoglobulin heavy variable 1-17 [Source:MGI Symbol;Acc:MGI:3647700] predicted gene, 20056 [Source:MGI Symbol;Acc:MGI:5012241] immunoglobulin heavy variable V1-38 [Source:MGI Symbol;Acc:MGI:5009911] immunoglobulin heavy variable V3-4 [Source:MGI Symbol;Acc:MGI:3644034] predicted gene, 20743 [Source:MGI Symbol;Acc:MGI:5434099] predicted gene, 38101 [Source:MGI Symbol;Acc:MGI:5611329] predicted gene 7292 [Source:MGI Symbol;Acc:MGI:3645786] predicted gene, 38081 [Source:MGI Symbol;Acc:MGI:5611309] immunoglobulin heavy variable 1-14 [Source:MGI Symbol;Acc:MGI:4439781] predicted gene, 37423 [Source:MGI Symbol;Acc:MGI:5610651] immunoglobulin heavy variable 8-8 [Source:MGI Symbol;Acc:MGI:3815333] predicted gene, 18407 [Source:MGI Symbol;Acc:MGI:5010592] predicted gene 4610 [Source:MGI Symbol;Acc:MGI:3782793] predicted gene 5034 [Source:MGI Symbol;Acc:MGI:3648000] predicted gene 6394 [Source:MGI Symbol;Acc:MGI:3648319] T cell receptor alpha variable 22 [Source:MGI Symbol;Acc:MGI:5009957] predicted gene, 30275 [Source:MGI Symbol;Acc:MGI:5589434] immunoglobulin kappa variable 4-60 [Source:MGI Symbol;Acc:MGI:3708737]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

predicted gene 42636 [Source:MGI Symbol;Acc:MGI:5662773] immunoglobulin kappa chain variable 9-128 [Source:MGI Symbol;Acc:MGI:3809196] predicted gene 5869 [Source:MGI Symbol;Acc:MGI:3648808] predicted gene 42520 [Source:MGI Symbol;Acc:MGI:5662657] T cell receptor delta, constant region [Source:MGI Symbol;Acc:MGI:98612] predicted gene 43388 [Source:MGI Symbol;Acc:MGI:5663525] predicted gene 43445 [Source:MGI Symbol;Acc:MGI:5663582] predicted gene 9729 [Source:MGI Symbol;Acc:MGI:3780133] immunoglobulin kappa variable 1-108 [Source:MGI Symbol;Acc:MGI:3644576] guanylate-binding protein 10 [Source:MGI Symbol;Acc:MGI:4359647] predicted gene 43310 [Source:MGI Symbol;Acc:MGI:5663447] predicted gene 42870 [Source:MGI Symbol;Acc:MGI:5663007] RIKEN cDNA A530030E21 gene [Source:MGI Symbol;Acc:MGI:2444617] predicted gene 43340 [Source:MGI Symbol;Acc:MGI:5663477] immunoglobulin lambda joining 3 [Source:MGI Symbol;Acc:MGI:5293407] predicted gene, 20568 [Source:MGI Symbol;Acc:MGI:5295675] predicted gene, 19708 [Source:MGI Symbol;Acc:MGI:5011893] predicted gene 3716 [Source:MGI Symbol;Acc:MGI:3781892] predicted gene 7285 [Source:MGI Symbol;Acc:MGI:3647212] predicted gene 4742 [Source:MGI Symbol;Acc:MGI:3645661] immunoglobulin kappa variable 4-77 [Source:MGI Symbol;Acc:MGI:3647937] predicted gene 43743 [Source:MGI Symbol;Acc:MGI:5663880] predicted gene 43815 [Source:MGI Symbol;Acc:MGI:5663952] immunoglobulin lambda constant 3 [Source:MGI Symbol;Acc:MGI:99886] predicted gene 5855 [Source:MGI Symbol;Acc:MGI:3645472] immunoglobulin heavy variable 1-86 [Source:MGI Symbol;Acc:MGI:3645729] immunoglobulin kappa variable 2-109 [Source:MGI Symbol;Acc:MGI:3642626] predicted gene 43684 [Source:MGI Symbol;Acc:MGI:5663821] predicted gene, 30211 [Source:MGI Symbol;Acc:MGI:5589370] RIKEN cDNA 4930519L02 gene [Source:MGI Symbol;Acc:MGI:1922335] predicted gene 43305 [Source:MGI Symbol;Acc:MGI:5663442] immunoglobulin heavy variable 1-83 [Source:MGI Symbol;Acc:MGI:3648939] predicted gene 43292 [Source:MGI Symbol;Acc:MGI:5663429] T cell receptor gamma joining 2 [Source:MGI Symbol;Acc:MGI:4439598] predicted gene 43329 [Source:MGI Symbol;Acc:MGI:5663466] predicted gene 42890 [Source:MGI Symbol;Acc:MGI:5663027] immunoglobulin lambda constant 1 [Source:MGI Symbol;Acc:MGI:99546] expressed sequence AI506816 [Source:MGI Symbol;Acc:MGI:2140929] predicted gene 8493 [Source:MGI Symbol;Acc:MGI:3779800] olfactory receptor 241, pseudogene 1 [Source:MGI Symbol;Acc:MGI:3030075] predicted gene 42892 [Source:MGI Symbol;Acc:MGI:5663029] predicted gene 43434 [Source:MGI Symbol;Acc:MGI:5663571] RIKEN cDNA 5830416I19 gene [Source:MGI Symbol;Acc:MGI:1922007] predicted gene, 19409 [Source:MGI Symbol;Acc:MGI:5011594] predicted gene 8539 [Source:MGI Symbol;Acc:MGI:3779802] predicted gene 3519 [Source:MGI Symbol;Acc:MGI:3781696] immunoglobulin kappa variable 4-73 [Source:MGI Symbol;Acc:MGI:3645825] immunoglobulin kappa chain variable 20-101-2 [Source:MGI Symbol;Acc:MGI:5009884] immunoglobulin lambda joining 3 pseudogene [Source:MGI Symbol;Acc:MGI:3645901] predicted gene 42990 [Source:MGI Symbol;Acc:MGI:5663127] predicted gene 42585 [Source:MGI Symbol;Acc:MGI:5662722]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

immunoglobulin heavy variable 1-73 [Source:MGI Symbol;Acc:MGI:3645131] immunoglobulin heavy variable 1-70 [Source:MGI Symbol;Acc:MGI:3644620] predicted gene, 36266 [Source:MGI Symbol;Acc:MGI:5595425] immunoglobulin kappa variable 2-116 [Source:MGI Symbol;Acc:MGI:3647785] predicted gene 43534 [Source:MGI Symbol;Acc:MGI:5663671] immunoglobulin lambda joining 1 [Source:MGI Symbol;Acc:MGI:5009822] DNA segment, Chr 5, ERATO Doi 605, expressed [Source:MGI Symbol;Acc:MGI:1277165] predicted gene, 20186 [Source:MGI Symbol;Acc:MGI:5012371] predicted gene, 29778 [Source:MGI Symbol;Acc:MGI:5588937] predicted gene 43196 [Source:MGI Symbol;Acc:MGI:5663333] predicted gene, 19590 [Source:MGI Symbol;Acc:MGI:5011775] predicted gene 43808 [Source:MGI Symbol;Acc:MGI:5663945] predicted pseudogene 7452 [Source:MGI Symbol;Acc:MGI:3645151] predicted gene 7478 [Source:MGI Symbol;Acc:MGI:3648572] predicted gene 42732 [Source:MGI Symbol;Acc:MGI:5662869] predicted gene 3375 [Source:MGI Symbol;Acc:MGI:3781553] predicted gene, 32479 [Source:MGI Symbol;Acc:MGI:5591638] predicted gene, 44135 [Source:MGI Symbol;Acc:MGI:5690527] predicted gene, 44250 [Source:MGI Symbol;Acc:MGI:5690642] predicted gene, 44069 [Source:MGI Symbol;Acc:MGI:5690461] predicted gene, 43890 [Source:MGI Symbol;Acc:MGI:5690282] predicted gene, 44075 [Source:MGI Symbol;Acc:MGI:5690467] predicted gene, 44210 [Source:MGI Symbol;Acc:MGI:5690602] predicted gene, 43909 [Source:MGI Symbol;Acc:MGI:5690301] predicted gene, 44428 [Source:MGI Symbol;Acc:MGI:5690820] predicted gene, 19434 [Source:MGI Symbol;Acc:MGI:5011619] predicted gene, 44292 [Source:MGI Symbol;Acc:MGI:5690684] upstream transcription factor 2, pseudogene 1 [Source:MGI Symbol;Acc:MGI:2153531] predicted gene 45205 [Source:MGI Symbol;Acc:MGI:5753781] predicted gene, 36159 [Source:MGI Symbol;Acc:MGI:5595318] predicted gene 45206 [Source:MGI Symbol;Acc:MGI:5753782] predicted gene 6905 [Source:MGI Symbol;Acc:MGI:3644964] tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta, pseudogene 1 [Source:MGI Sym predicted gene 5587 [Source:MGI Symbol;Acc:MGI:3645641] predicted gene, 18310 [Source:MGI Symbol;Acc:MGI:5010495] predicted gene 44645 [Source:MGI Symbol;Acc:MGI:5753221] predicted pseudogene 6916 [Source:MGI Symbol;Acc:MGI:3644024] predicted gene 44931 [Source:MGI Symbol;Acc:MGI:5753507] predicted gene, 34121 [Source:MGI Symbol;Acc:MGI:5593280] RIKEN cDNA 4933431G14 gene [Source:MGI Symbol;Acc:MGI:1918515] RIKEN cDNA 2310043P16 gene [Source:MGI Symbol;Acc:MGI:1917385] predicted gene, 35082 [Source:MGI Symbol;Acc:MGI:5594241] predicted gene 10648 [Source:MGI Symbol;Acc:MGI:3642037] RIKEN cDNA A230103L15 gene [Source:MGI Symbol;Acc:MGI:1925005] predicted gene, 39059 [Source:MGI Symbol;Acc:MGI:5621944] zinc finger protein 264 [Source:MGI Symbol;Acc:MGI:2151059] DNA segment, Chr 7, Brigham & Women's Genetics 0826 expressed [Source:MGI Symbol;Acc:MGI:106455] predicted gene 45104 [Source:MGI Symbol;Acc:MGI:5753680] predicted gene 44659 [Source:MGI Symbol;Acc:MGI:5753235] predicted gene 44751 [Source:MGI Symbol;Acc:MGI:5753327] predicted gene 44860 [Source:MGI Symbol;Acc:MGI:5753436]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

predicted gene 2814 [Source:MGI Symbol;Acc:MGI:3780984] protein arginine N-methyltransferase 1 [Source:MGI Symbol;Acc:MGI:107846] predicted gene, 31597 [Source:MGI Symbol;Acc:MGI:5590756] RIKEN cDNA 0610005C13 gene [Source:MGI Symbol;Acc:MGI:1918911] predicted gene 45246 [Source:MGI Symbol;Acc:MGI:5791082] neurexophilin and PC-esterase domain family, member 1, pseudogene [Source:MGI Symbol;Acc:MGI:3646632] poliovirus receptor related immunoglobulin domain containing [Source:MGI Symbol;Acc:MGI:5596028] predicted gene, 35021 [Source:MGI Symbol;Acc:MGI:5594180] predicted gene 45266 [Source:MGI Symbol;Acc:MGI:5791102] predicted gene 45479 [Source:MGI Symbol;Acc:MGI:5791315] predicted gene, 18227 [Source:MGI Symbol;Acc:MGI:5010412] predicted gene 45286 [Source:MGI Symbol;Acc:MGI:5791122] predicted gene 45640 [Source:MGI Symbol;Acc:MGI:5791476] predicted gene 45437 [Source:MGI Symbol;Acc:MGI:5791273] RIKEN cDNA C030029H02 gene [Source:MGI Symbol;Acc:MGI:1924633] predicted gene 45844 [Source:MGI Symbol;Acc:MGI:5804959] predicted gene 9347 [Source:MGI Symbol;Acc:MGI:3648409] ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 [S predicted gene 45620 [Source:MGI Symbol;Acc:MGI:5791456] predicted gene, 20100 [Source:MGI Symbol;Acc:MGI:5012285] predicted gene 45552 [Source:MGI Symbol;Acc:MGI:5791388] predicted gene 8189 [Source:MGI Symbol;Acc:MGI:3779786] nuclear distribution gene C homolog (Aspergillus), pseudogene 1 [Source:MGI Symbol;Acc:MGI:2142657] RIKEN cDNA A030001D20 gene [Source:MGI Symbol;Acc:MGI:3696869] predicted gene, 42031 [Source:MGI Symbol;Acc:MGI:5624916] expressed sequence AW046200 [Source:MGI Symbol;Acc:MGI:2142745] predicted gene 45757 [Source:MGI Symbol;Acc:MGI:5804872] predicted gene, 21769 [Source:MGI Symbol;Acc:MGI:5433933] RIKEN cDNA A630001O12 gene [Source:MGI Symbol;Acc:MGI:3041181] predicted gene 4316 [Source:MGI Symbol;Acc:MGI:3782497] predicted gene 7730 [Source:MGI Symbol;Acc:MGI:3647355] predicted gene, 18860 [Source:MGI Symbol;Acc:MGI:5011045] predicted gene 45774 [Source:MGI Symbol;Acc:MGI:5804889] predicted gene, 42047 [Source:MGI Symbol;Acc:MGI:5624932] predicted gene, 40466 [Source:MGI Symbol;Acc:MGI:5623351] predicted gene 10060 [Source:MGI Symbol;Acc:MGI:3710638] predicted gene, 33460 [Source:MGI Symbol;Acc:MGI:5592619] predicted gene, 46223 [Source:MGI Symbol;Acc:MGI:5825860] predicted gene, 39318 [Source:MGI Symbol;Acc:MGI:5622203] predicted gene 6545 [Source:MGI Symbol;Acc:MGI:3643874] predicted gene, 48293 [Source:MGI Symbol;Acc:MGI:6097731] predicted gene, 48719 [Source:MGI Symbol;Acc:MGI:6098371] predicted gene, 39307 [Source:MGI Symbol;Acc:MGI:5622192] RIKEN cDNA 4933404K13 gene [Source:MGI Symbol;Acc:MGI:1918268] predicted gene, 48537 [Source:MGI Symbol;Acc:MGI:6098081] predicted gene, 47043 [Source:MGI Symbol;Acc:MGI:6095746] predicted gene, 47230 [Source:MGI Symbol;Acc:MGI:6096044] predicted gene, 47652 [Source:MGI Symbol;Acc:MGI:6096735] predicted gene 8162 [Source:MGI Symbol;Acc:MGI:3644710] predicted gene 3365 [Source:MGI Symbol;Acc:MGI:3781543] olfactory receptor 157 [Source:MGI Symbol;Acc:MGI:1352684]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

predicted gene 10686 [Source:MGI Symbol;Acc:MGI:3704331] predicted gene, 20234 [Source:MGI Symbol;Acc:MGI:5012419] predicted gene, 40020 [Source:MGI Symbol;Acc:MGI:5622905] predicted gene, 47828 [Source:MGI Symbol;Acc:MGI:6097024] TEC predicted gene 5182 [Source:MGI Symbol;Acc:MGI:3649174] predicted gene 5176 [Source:MGI Symbol;Acc:MGI:3644450] predicted gene 4864 [Source:MGI Symbol;Acc:MGI:3643492] predicted gene, 35189 [Source:MGI Symbol;Acc:MGI:5594348] predicted gene, 32220 [Source:MGI Symbol;Acc:MGI:5591379] predicted gene 8960 [Source:MGI Symbol;Acc:MGI:3642929] predicted gene, 30906 [Source:MGI Symbol;Acc:MGI:5590065] predicted gene, 36229 [Source:MGI Symbol;Acc:MGI:5595388] predicted gene 8188 [Source:MGI Symbol;Acc:MGI:3646272] predicted gene, 36208 [Source:MGI Symbol;Acc:MGI:5595367] predicted gene, 48786 [Source:MGI Symbol;Acc:MGI:6098486] Ifng antisense RNA 1 [Source:MGI Symbol;Acc:MGI:1934663] predicted gene, 30262 [Source:MGI Symbol;Acc:MGI:5589421] predicted gene, 34983 [Source:MGI Symbol;Acc:MGI:5594142] predicted gene, 47752 [Source:MGI Symbol;Acc:MGI:6096897] predicted gene, 40773 [Source:MGI Symbol;Acc:MGI:5623658] predicted gene, 47761 [Source:MGI Symbol;Acc:MGI:6096912] predicted gene, 46194 [Source:MGI Symbol;Acc:MGI:5825831] predicted gene, 47425 [Source:MGI Symbol;Acc:MGI:6096368] predicted gene, 32687 [Source:MGI Symbol;Acc:MGI:5591846] predicted gene, 36172 [Source:MGI Symbol;Acc:MGI:5595331] predicted gene, 40645 [Source:MGI Symbol;Acc:MGI:5623530] predicted gene, 47917 [Source:MGI Symbol;Acc:MGI:6097168] predicted gene, 47006 [Source:MGI Symbol;Acc:MGI:6095684] predicted gene, 46224 [Source:MGI Symbol;Acc:MGI:5825861] predicted gene, 47015 [Source:MGI Symbol;Acc:MGI:6095697] predicted gene, 48496 [Source:MGI Symbol;Acc:MGI:6098022] RIKEN cDNA 5830428M24 gene [Source:MGI Symbol;Acc:MGI:1923312] predicted gene, 47021 [Source:MGI Symbol;Acc:MGI:6095708] predicted gene, 47469 [Source:MGI Symbol;Acc:MGI:6096437] predicted gene, 48734 [Source:MGI Symbol;Acc:MGI:6098397] predicted gene, 47813 [Source:MGI Symbol;Acc:MGI:6096997] testis derived transcript 3, pseudogene [Source:MGI Symbol;Acc:MGI:3582925] predicted gene 4811 [Source:MGI Symbol;Acc:MGI:3648985] predicted gene, 33016 [Source:MGI Symbol;Acc:MGI:5592175] predicted gene, 47541 [Source:MGI Symbol;Acc:MGI:6096550] expressed sequence AU015791 [Source:MGI Symbol;Acc:MGI:2144938] predicted gene 7868 [Source:MGI Symbol;Acc:MGI:3644628] predicted gene 7240 [Source:MGI Symbol;Acc:MGI:3643235] predicted gene 10457 [Source:MGI Symbol;Acc:MGI:3642070] predicted gene, 48358 [Source:MGI Symbol;Acc:MGI:6097826] predicted pseudogene 7622 [Source:MGI Symbol;Acc:MGI:3647115] RIKEN cDNA 5033406O09 gene [Source:MGI Symbol;Acc:MGI:1923205] predicted gene, 48838 [Source:MGI Symbol;Acc:MGI:6098568] predicted gene, 47250 [Source:MGI Symbol;Acc:MGI:6096077] predicted gene, 46339 [Source:MGI Symbol;Acc:MGI:5825976]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

predicted gene, 47705 [Source:MGI Symbol;Acc:MGI:6096822] predicted gene, 20075 [Source:MGI Symbol;Acc:MGI:5012260] predicted gene, 34215 [Source:MGI Symbol;Acc:MGI:5593374] predicted gene, 35279 [Source:MGI Symbol;Acc:MGI:5594438] predicted gene 4814 [Source:MGI Symbol;Acc:MGI:3647983] predicted gene, 47994 [Source:MGI Symbol;Acc:MGI:6097290] predicted gene, 30411 [Source:MGI Symbol;Acc:MGI:5589570] RIKEN cDNA F630042J09 gene [Source:MGI Symbol;Acc:MGI:3642133] predicted gene, 48837 [Source:MGI Symbol;Acc:MGI:6098566] predicted gene, 48732 [Source:MGI Symbol;Acc:MGI:6098394] predicted gene, 47732 [Source:MGI Symbol;Acc:MGI:6096868] predicted gene 8990 [Source:MGI Symbol;Acc:MGI:3647409] predicted gene, 48370 [Source:MGI Symbol;Acc:MGI:6097842] predicted gene, 30918 [Source:MGI Symbol;Acc:MGI:5590077] predicted gene 5452 [Source:MGI Symbol;Acc:MGI:3645281] predicted gene, 47558 [Source:MGI Symbol;Acc:MGI:6096579] predicted gene 4815 [Source:MGI Symbol;Acc:MGI:3643439] predicted gene 5203 [Source:MGI Symbol;Acc:MGI:3643899] predicted gene, 49064 [Source:MGI Symbol;Acc:MGI:6118443] predicted gene, 47754 [Source:MGI Symbol;Acc:MGI:6096900] predicted gene, 46432 [Source:MGI Symbol;Acc:MGI:5826069] RIKEN cDNA A630019I02 gene [Source:MGI Symbol;Acc:MGI:5439422] predicted gene 7107 [Source:MGI Symbol;Acc:MGI:3648887] predicted gene, 35019 [Source:MGI Symbol;Acc:MGI:5594178] epiplakin 1 [Source:MGI Symbol;Acc:MGI:2386306] predicted gene, 41290 [Source:MGI Symbol;Acc:MGI:5624175] predicted gene 7691 [Source:MGI Symbol;Acc:MGI:3645861] predicted gene 4606 [Source:MGI Symbol;Acc:MGI:3782789] ribosomal protein L19, pseudogene 5 [Source:MGI Symbol;Acc:MGI:3644768] predicted gene, 35167 [Source:MGI Symbol;Acc:MGI:5594326] predicted gene 2682 [Source:MGI Symbol;Acc:MGI:3780851] novel transcript predicted gene, 34643 [Source:MGI Symbol;Acc:MGI:5593802] predicted gene, 49483 [Source:MGI Symbol;Acc:MGI:6155157] predicted gene, 20369 [Source:MGI Symbol;Acc:MGI:5012554] predicted gene, 18979 [Source:MGI Symbol;Acc:MGI:5011164] predicted gene, 49413 [Source:MGI Symbol;Acc:MGI:6155041] transmembrane protein 249 [Source:MGI Symbol;Acc:MGI:3647471] predicted gene, 49504 [Source:MGI Symbol;Acc:MGI:6155192] predicted gene, 49553 [Source:MGI Symbol;Acc:MGI:6155262] predicted gene, 18911 [Source:MGI Symbol;Acc:MGI:5011096] RIKEN cDNA I730030J21 gene [Source:MGI Symbol;Acc:MGI:3588279] predicted 2808 [Source:NCBI gene;Acc:100040500] novel transcript, antisense to Dscr3 novel transcript, antisense to D16Ertd472e ribosomal protein S3 (Rps3) pseudogene twist basic helix-loop-helix transcription factor 1 neighbor (Twistnb) pseudogene novel transcript, antisense to Cmss1 tubby like protein 4 (Tulp4) pseudogene CD2-associated protein (Cd2ap) pseudogene novel transcript

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

novel transcript zinc finger protein 106 (Zfp106) pseudogene novel transcript novel transcript interferon induced transmembrane protein 3 (Ifitm3) pseudogene Novel transcript guanine nucleotide binding protein (G protein), gamma 5 (Gng5) retrogene F-box protein 34 (Fbxo34) pseudogene microtubule-associated protein 7 (Map7) pseudogene general transcription factor III A (Gft3a) pseudogene mitochondrial ribosomal protein S10 (Mrps10) pseudogene novel transcript, antisense to Slc22a3 novel transcript Ewing sarcoma breakpoint region 1 (Ewsr1) pseudogene

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

logFC logCPM LR PValue FDR 0.912714165 8.052194789 8.089768436 0.004451585 0.034102382 -1.087649685 3.772266695 11.46958668 0.000707444 0.007592645 1.084459973 5.807617691 15.25890222 9.37339E-05 0.001339636 1.492798501 7.183430657 11.88828441 0.000564881 0.006245585 -5.061282903 -1.773435649 12.83183047 0.000340772 0.004065425 -2.106489169 1.124924945 17.95410831 2.26295E-05 0.000385873 4.491770446 -0.525450015 42.05049518 8.89467E-11 4.47676E-09 1.56146036 3.249297232 22.42078345 2.18991E-06 4.9088E-05 -0.940926082 5.829230588 13.25726635 0.000271525 0.003340032 -0.628276148 5.553123478 8.827302686 0.002967567 0.024777743 -1.393450078 6.554178363 26.36098795 2.83203E-07 7.70531E-06 2.483616493 -0.656389776 18.77664832 1.46955E-05 0.000264253 -0.727168979 5.772862241 10.62389386 0.001116357 0.011090681 -0.597684062 6.266570949 7.756238346 0.005352733 0.039344873 2.132764887 -1.110124958 12.86536122 0.00033472 0.003998048 -0.6461274 6.392281472 10.24192146 0.001372845 0.013143696 1.986486168 5.739297483 37.58850321 8.73579E-10 3.82287E-08 3.279731941 2.018167597 38.40889083 5.73704E-10 2.57321E-08 2.249140414 0.3098664 16.5366834 4.77179E-05 0.000742612 1.442088329 4.407045261 20.9555315 4.70069E-06 9.51684E-05 -1.869972196 0.604549626 10.58643538 0.001139204 0.011283654 -0.907302411 5.269612964 13.15171036 0.000287257 0.003500888 2.680893951 1.249907321 22.8854009 1.71953E-06 3.96876E-05 -0.746923578 5.923554346 7.264349149 0.007033675 0.048730683 0.616869107 6.142737673 8.163646998 0.004273834 0.033125566 1.514943064 2.474449754 17.71273508 2.56901E-05 0.000429907 2.102579247 4.497022504 21.33411051 3.85805E-06 7.95748E-05 2.739735448 3.624313149 28.38582349 9.93905E-08 2.95631E-06 -0.850312902 5.202317706 14.18099383 0.000166039 0.002188045 2.558687222 6.718444615 44.38118932 2.70272E-11 1.48499E-09 5.415355175 -1.82828576 32.02619497 1.52108E-08 5.27776E-07 2.6554671 -0.574656787 16.0427917 6.19269E-05 0.000927966 2.342412627 0.807181173 27.87967449 1.29099E-07 3.7719E-06 -7.064113062 -1.113194929 31.29200404 2.21992E-08 7.42979E-07 -2.085546579 6.95751821 84.12419283 4.6465E-20 7.47217E-18 -1.550558638 0.248177498 9.373047359 0.002201991 0.019505325 1.03546967 4.171239036 8.557584635 0.003440856 0.027927837 2.564552926 3.537457154 19.46872129 1.02261E-05 0.000190463 -2.095881304 0.394785662 19.64762978 9.31187E-06 0.000175585 -0.719975621 5.561706073 8.373688853 0.003806921 0.030217054 3.044080444 3.018700989 25.14713299 5.31186E-07 1.36541E-05 -1.465083959 4.764105685 22.32385018 2.30328E-06 5.1075E-05 1.047942168 3.815532811 11.64531822 0.000643643 0.007018337 -0.894214784 5.912277927 10.89472818 0.000964383 0.009853049 1.774127442 4.413567925 34.18813109 5.00332E-09 1.91053E-07 -0.847768864 6.347203545 12.15784278 0.000488819 0.005503037 0.685572031 5.298588285 9.119213325 0.002529387 0.02177679 1.597983153 7.053822539 15.86454494 6.80416E-05 0.001011166 1.913339299 -0.201266718 12.36379695 0.00043774 0.005013601

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1.721578999 2.163204718 7.971829294 0.00475109 0.03577334 -2.131760519 6.386438162 56.23188048 6.44087E-14 5.01576E-12 -2.642778684 -1.770337604 10.19351839 0.001409352 0.01341529 0.710139478 5.634958064 8.209189017 0.004167877 0.032469719 1.307707845 3.550603343 15.50212871 8.24124E-05 0.001201265 -2.981318454 0.083007096 31.38652958 2.11443E-08 7.10074E-07 1.809171135 1.476407313 16.09979742 6.00905E-05 0.00090387 1.165017396 3.84165828 8.374182608 0.003805887 0.030217054 0.936983881 6.023049839 11.32377053 0.000765212 0.008094058 1.919211189 5.930011401 23.34055814 1.35708E-06 3.20323E-05 3.667303814 5.109981493 58.76139046 1.78E-14 1.47935E-12 4.016017183 0.837970145 43.83333532 3.57563E-11 1.91669E-09 1.952187204 2.469399781 16.71779008 4.33724E-05 0.00068359 2.252008868 0.513197839 12.34445771 0.000442298 0.005062874 -1.100250888 5.010971518 14.93805786 0.000111099 0.001549745 -1.237600385 7.720001373 16.59947788 4.61637E-05 0.000722404 -0.595390558 5.893604342 7.954070475 0.004797934 0.036057425 3.238055662 5.696320674 36.27866473 1.71026E-09 7.01845E-08 1.455593149 3.319655864 12.70418051 0.000364839 0.004299453 1.455427428 3.499269442 18.78997703 1.45932E-05 0.000262651 -1.789609674 1.584709738 17.94582922 2.27282E-05 0.000386888 0.961773993 7.174660001 10.22921761 0.001382333 0.013218802 2.024664484 6.570967354 59.90102916 9.97493E-15 8.50449E-13 1.062229127 4.591224142 12.39618418 0.000430212 0.004947439 2.2833934 1.90738796 10.84597786 0.000990106 0.010058702 2.382933942 0.857719662 9.138543393 0.002502803 0.021618095 -0.765976478 5.470948445 12.43316124 0.000421777 0.004858915 -1.281872997 6.051850408 23.328726 1.36545E-06 3.21532E-05 2.184649774 -0.504951759 15.06341153 0.000103959 0.001467743 4.554220142 4.076011183 83.86458891 5.29851E-20 8.45199E-18 1.95056347 -1.72576946 9.826001156 0.00172062 0.015911111 3.650751823 3.872240986 31.23909835 2.28125E-08 7.62215E-07 3.099127947 0.548707247 17.1178975 3.51297E-05 0.000565391 1.682158221 3.311283932 14.55086166 0.000136426 0.001843245 -1.286283943 3.330966763 8.720568104 0.0031464 0.02599657 2.239067434 1.85313695 22.99343402 1.62556E-06 3.78722E-05 -5.507506134 2.020907362 104.0531414 1.96962E-24 4.69386E-22 1.0166883 4.204864858 7.744506952 0.005387617 0.039557187 3.289771075 1.547854704 25.14588672 5.31529E-07 1.36541E-05 0.83150501 3.461646491 7.341196908 0.006739195 0.047169598 4.949475509 -1.192953574 39.43921587 3.38432E-10 1.5751E-08 2.326639416 -0.595539434 18.56881397 1.6388E-05 0.000290461 -6.157332633 4.243604108 116.3204102 4.04389E-27 1.1763E-24 3.437009535 -0.010483466 28.48833201 9.42649E-08 2.81655E-06 -0.681411632 5.583036445 8.443765699 0.00366297 0.029392917 -1.496583371 4.72063059 34.24714361 4.85387E-09 1.86065E-07 -1.007874215 6.101801853 8.773851701 0.003055795 0.025375155 -1.375433668 0.720111769 8.64625085 0.003277351 0.026876449 1.506888261 0.762229875 8.33230824 0.003894614 0.03074041 2.526120169 -1.220120764 16.46847083 4.94659E-05 0.000766799 -0.639655216 6.784680515 7.934318092 0.00485059 0.036384026

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1.912207312 3.304293872 23.04425289 1.58315E-06 3.7015E-05 1.685713473 -0.650584636 10.36133924 0.001286818 0.012495466 3.45918176 1.684858638 41.83607604 9.92551E-11 4.97029E-09 -0.826356998 5.25407049 10.61122674 0.001124031 0.011155711 -1.143445271 3.53565958 13.50262155 0.00023823 0.002988077 1.911222091 3.664454038 31.76129404 1.74333E-08 5.94534E-07 1.72826456 1.80995943 12.46664631 0.000414283 0.004791275 2.973634954 6.171849778 156.0600894 8.21366E-36 4.27543E-33 -1.367008309 4.522673803 18.76265109 1.48038E-05 0.000265716 -1.925623289 2.882069134 14.49465905 0.000140557 0.0018849 2.865683506 -0.577070655 16.41697243 5.08281E-05 0.000784839 -0.716159106 5.564242363 8.107652061 0.004407878 0.033819951 0.786772811 5.201755592 7.922679346 0.004881892 0.036549518 4.381118295 4.537990562 46.05644456 1.14895E-11 6.66456E-10 2.02609191 -1.185751097 9.302310853 0.00228865 0.020101908 1.471406395 -0.280274791 7.70877246 0.005495311 0.040139309 -1.214993701 8.632224001 10.29561214 0.001333469 0.012891505 -0.699603928 5.355862918 8.478647171 0.003593392 0.028963854 1.583927298 6.243184206 38.84439268 4.5897E-10 2.09664E-08 3.736230585 6.87263124 34.16785711 5.05572E-09 1.92682E-07 1.144199961 3.02718477 10.2509207 0.001366164 0.013092405 1.515063871 2.861556983 11.71346136 0.000620496 0.006784638 -1.590739773 5.587645757 26.05433699 3.31942E-07 8.84881E-06 -0.734548337 7.757597708 7.978819976 0.004732778 0.03566261 9.163995173 2.016908295 148.9618261 2.92338E-34 1.37677E-31 1.373269887 4.697488653 18.11997247 2.07414E-05 0.000358624 1.296082365 2.72186425 12.27569588 0.000458896 0.005213643 1.611898702 9.076716087 10.71044073 0.001065326 0.010696527 0.840333108 6.795352707 9.472030368 0.002086283 0.018681161 5.054705809 -2.54926698 12.86902394 0.000334066 0.003995055 1.952455469 -0.255405373 12.37422966 0.0004353 0.004996096 2.092544792 0.499354465 7.868753813 0.00502963 0.037385692 4.429122673 -2.415315824 9.374615075 0.002200109 0.019497382 -0.886447499 5.94441285 12.97542239 0.000315607 0.003797263 -1.113214067 3.419992731 7.272622094 0.007001352 0.048523736 1.326580937 5.32055773 20.03977732 7.58479E-06 0.000146368 -0.783903758 4.667950541 10.38205328 0.001272461 0.012374277 -1.244567818 4.66596883 22.52682937 2.07229E-06 4.67301E-05 1.678381363 2.942811291 17.26241292 3.25564E-05 0.000529576 2.469117374 -0.99775036 11.33717432 0.000759708 0.008044449 -0.783102973 4.391534442 7.689840326 0.005553254 0.040472868 3.156511808 0.203007751 28.4894678 9.42096E-08 2.81655E-06 -3.66577204 0.259897651 10.05170402 0.001522071 0.01428205 0.902797539 4.767062228 12.74860693 0.000356274 0.004219454 1.118307203 2.334986947 8.376532111 0.00380097 0.030205996 3.436267458 2.740234175 17.30976924 3.1755E-05 0.000516966 2.731134081 1.927032277 35.1151883 3.10767E-09 1.2294E-07 2.890468041 -0.042421633 22.41953411 2.19134E-06 4.9088E-05 0.917848678 6.566688635 14.51785791 0.000138837 0.001866893 0.618926522 6.664591322 7.539038101 0.006037627 0.043205563 0.863213288 5.48663049 9.907564028 0.001646008 0.015278295

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

-0.953049033 4.149600416 9.952213372 0.001606561 0.014989519 2.305029688 4.062833273 36.49439284 1.53106E-09 6.32242E-08 2.028253111 7.295376273 10.5882331 0.001138097 0.011278335 0.858920418 6.912355961 10.15908263 0.001435921 0.013622306 2.153308684 0.684890423 12.78637775 0.000349153 0.00414789 1.95076812 2.236344864 22.56612777 2.03033E-06 4.60022E-05 1.032983455 2.401593445 8.175574744 0.004245821 0.032934254 1.481511385 2.582258958 10.28808213 0.001338922 0.012937896 3.394673983 0.841275564 38.52169252 5.41485E-10 2.44534E-08 4.538506529 3.931562476 130.1200319 3.85733E-30 1.36246E-27 1.820795629 0.083563711 11.81897528 0.000586301 0.006449965 2.823278635 4.465600531 43.1379706 5.10126E-11 2.66234E-09 2.821821231 1.380119092 16.35095703 5.26296E-05 0.000806987 2.045678501 4.579483349 11.12295206 0.00085266 0.00888599 2.619817476 1.767716183 21.68688293 3.20979E-06 6.80488E-05 -0.863662012 3.059885409 7.250996056 0.007086169 0.049025685 2.780430404 -1.722673993 10.88952715 0.000967095 0.009870558 1.549258296 3.145440569 13.02550574 0.000307277 0.003708323 -1.373721975 8.782699127 13.39480821 0.000252322 0.003148848 -0.740596989 4.539669601 8.159933531 0.004282594 0.033180459 1.195566515 7.477346723 13.47740744 0.000241453 0.003024664 2.035899363 -2.043879054 7.641670645 0.005703507 0.041339452 -4.118730912 1.009861215 39.56775997 3.16872E-10 1.48524E-08 -1.751666531 -0.507579352 8.936839992 0.002794758 0.023642558 0.825745963 4.854390087 9.82032607 0.001725937 0.015945372 3.428497706 4.725686108 30.11373648 4.07435E-08 1.30617E-06 1.725191283 2.817171993 16.3154576 5.36247E-05 0.000819704 -0.654381391 5.760856072 8.143665075 0.004321185 0.033359682 2.852081233 3.374428671 15.08362682 0.000102852 0.001455224 2.701041785 0.272525088 20.49965186 5.96421E-06 0.000117854 1.387384 0.252679479 9.687548426 0.001855209 0.016887474 1.909456135 4.502185514 21.73501038 3.13026E-06 6.64341E-05 1.238719184 2.624600865 10.85524484 0.000985163 0.010018782 2.236821151 1.066959591 13.92060438 0.000190697 0.002468572 1.48768539 4.735732832 24.85151078 6.19205E-07 1.5763E-05 0.836997321 5.085806313 14.40893197 0.000147103 0.001960711 -1.303270922 2.932174221 11.52601778 0.000686289 0.007401739 2.84866975 5.913995628 25.98972056 3.4324E-07 9.12539E-06 2.136537945 1.425430819 23.66152305 1.14856E-06 2.75043E-05 0.600812195 6.009330702 8.079317632 0.00447733 0.034209521 0.810719171 4.861598047 10.04106427 0.001530887 0.014357966 2.928092932 -2.417708327 12.56662439 0.000392697 0.004577226 2.06963183 1.022549271 19.216155 1.16721E-05 0.000214767 2.806473432 3.290151639 41.5987032 1.12068E-10 5.54174E-09 1.586799951 0.35786669 8.796356978 0.003018327 0.025127314 1.050759019 5.334961639 16.61054359 4.58952E-05 0.00071934 1.129596205 3.370509351 10.80213675 0.00101383 0.010257575 -0.769550689 5.001703911 8.971368447 0.002742431 0.023251303 2.329454985 1.363064679 25.81089244 3.76557E-07 9.90541E-06 4.08815923 2.300435759 11.5881276 0.000663742 0.007209142 4.141838531 1.151927967 31.59110385 1.90299E-08 6.47869E-07

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

1.266498822 4.086509985 20.23200306 6.85957E-06 0.000134206 0.968619439 5.960807396 15.48750431 8.30525E-05 0.001208078 1.723397241 6.575256377 25.95026049 3.50328E-07 9.28886E-06 2.502441407 1.45241996 22.87784276 1.7263E-06 3.97975E-05 -0.798864838 6.6013142 10.65985511 0.00109486 0.010917226 -1.304188509 4.256741521 14.68797823 0.000126853 0.001734035 1.782068053 5.952668975 30.01785205 4.28087E-08 1.37016E-06 2.874597825 -1.731492973 8.853534864 0.002925218 0.024496536 -1.048793376 5.279118141 12.67866729 0.000369851 0.004349378 2.274451602 0.539358311 14.02345607 0.000180544 0.002350999 5.968068677 -0.778873624 46.98252067 7.16226E-12 4.3324E-10 1.376418042 0.900076556 10.97612189 0.000922934 0.00950319 1.008588101 3.909201062 10.17942282 0.001420166 0.013505235 0.630376373 5.71492817 8.620642 0.003323747 0.027155602 2.196882707 2.713319973 22.04265172 2.66659E-06 5.7708E-05 0.838578595 4.760201113 7.750006137 0.005371236 0.039451558 -1.279655488 2.184802878 9.74782182 0.001795353 0.016468725 -2.869030648 2.660845491 17.57801455 2.75758E-05 0.000458361 -1.019991872 5.35865288 17.71274064 2.569E-05 0.000429907 -0.793114731 6.166248006 11.04207569 0.000890671 0.009228571 -0.634747594 5.275042434 8.197541041 0.00419472 0.032648 2.523396103 0.326259832 15.45208936 8.46233E-05 0.001228063 1.523836811 1.232380957 9.747455998 0.001795711 0.016468725 2.099141298 2.441424908 19.95028597 7.94821E-06 0.000152046 2.746114419 3.820161083 44.37381751 2.71291E-11 1.48647E-09 1.528930415 4.785703418 17.87701071 2.35651E-05 0.000399073 0.623398723 6.304987671 7.297342212 0.006905669 0.048028877 1.327023544 2.721721815 10.46165173 0.001218783 0.01192851 1.578497201 9.622394155 10.49674603 0.00119585 0.01177646 3.373084776 1.59526504 49.4491419 2.03582E-12 1.33339E-10 1.197390757 1.499862546 7.48409463 0.006224636 0.044299835 1.392837311 6.818687003 10.2302318 0.001381573 0.013218802 1.173124513 2.051372844 7.598177225 0.005842734 0.042132438 2.244390219 -0.580872383 8.740398156 0.003112366 0.025769927 -0.917898945 7.285600289 11.7162855 0.000619555 0.006778096 -0.688409516 6.33347499 8.498826285 0.003553756 0.028679438 2.682078296 0.623442858 28.21770055 1.08409E-07 3.1959E-06 1.538560544 3.186425605 7.723107566 0.005451848 0.039875631 0.668954914 5.062376883 8.467986506 0.003614513 0.029074855 3.161302743 2.540767432 18.32507744 1.86239E-05 0.000325138 -0.736241757 6.815459486 7.914752527 0.004903329 0.036668371 2.089190982 2.999188118 35.5330081 2.50765E-09 1.00816E-07 1.405515274 3.963593253 16.81890054 4.11217E-05 0.000651231 2.264316374 3.544338917 40.32477138 2.15065E-10 1.02259E-08 1.05002837 5.145567471 13.17471289 0.000283752 0.003468862 2.119690293 0.673541823 18.47681759 1.71984E-05 0.000303464 -4.797207387 -1.17279448 24.4565594 7.60043E-07 1.89657E-05 -0.822455656 7.188920299 10.68621269 0.00107937 0.010810091 -1.420718089 0.73889708 11.56489801 0.000672086 0.007276331 1.565766794 5.039533437 7.943271332 0.00482665 0.036218187 -1.070266556 4.187913762 12.56257441 0.000393549 0.004582918

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3.268454382 0.955067068 26.66856014 2.4152E-07 6.68148E-06 1.781659396 1.895136884 14.8016161 0.000119433 0.001646263 0.974976696 7.7587898 7.526182698 0.006080862 0.043469263 2.444777471 -2.189366192 7.649749444 0.005678021 0.04118491 0.632774166 4.909297621 7.402312058 0.00651401 0.045918432 1.972362013 4.106584798 14.83253854 0.000117491 0.00162175 2.019618359 2.768997826 20.91820826 4.79317E-06 9.66451E-05 0.89343681 6.594392314 16.91684348 3.90535E-05 0.000622464 2.851847352 9.521903036 26.0701595 3.29233E-07 8.80031E-06 1.268977077 3.134391091 16.4172371 5.0821E-05 0.000784839 -0.666330897 4.81774847 7.605834722 0.005817972 0.041969181 -1.968649576 5.785134472 66.42421982 3.63607E-16 3.80537E-14 -1.048987364 4.559813879 16.09542148 6.02295E-05 0.000905273 0.726399785 5.727534091 8.006232619 0.004661662 0.035193769 2.20353093 7.448337913 40.81655855 1.6721E-10 8.06688E-09 1.179347099 2.706570526 9.259229772 0.002343115 0.020507444 3.673268746 0.954271771 37.62821641 8.55973E-10 3.75413E-08 -0.674635164 5.838013444 11.1644945 0.000833777 0.008716758 -0.97353995 6.493367255 14.79878995 0.000119612 0.001647084 1.511769482 5.556941484 14.62749745 0.000130989 0.001781959 3.256181565 2.424721452 12.5158179 0.000403521 0.004681318 2.328301785 -0.33483516 17.99528003 2.21453E-05 0.000378595 -1.084845862 3.149084887 8.565710102 0.003425533 0.02787209 -0.663108234 6.034374841 10.19543629 0.001407886 0.013407797 -1.042747916 4.898779563 13.64691059 0.000220604 0.002800736 6.082230256 1.182725822 100.1562435 1.40837E-23 3.16563E-21 2.222312896 -2.000384751 10.08271856 0.001496664 0.014083732 2.336436061 0.14492758 16.74847119 4.26766E-05 0.0006741 0.712702912 5.588242214 10.91535418 0.000953705 0.009774239 2.221909129 1.077821429 10.60962898 0.001125003 0.011159755 -0.783323021 4.403461369 7.618584814 0.00577698 0.041719121 -3.486056819 -1.492728505 18.95983096 1.335E-05 0.000242481 2.03984382 -1.996108489 8.072640834 0.004493858 0.034278485 -0.591293044 6.30342476 7.483652404 0.006226165 0.044299835 1.248119903 4.577706999 17.52027477 2.8426E-05 0.000470516 1.094999985 5.134272041 11.26689304 0.000789017 0.008314732 5.037524474 -1.239094761 45.30293583 1.68796E-11 9.5122E-10 -3.707215957 -1.758505947 8.131542577 0.004350172 0.033520219 0.7178749 6.445671677 7.637609909 0.005716361 0.041402279 1.791391454 1.358733082 18.46305037 1.7323E-05 0.000304862 2.501258807 2.402419058 20.80392923 5.08785E-06 0.000101552 -0.763413953 6.221465619 11.58724413 0.000664057 0.007209142 3.145337366 9.334138448 43.77492427 3.68395E-11 1.96942E-09 0.610162088 5.625426496 7.874124032 0.005014716 0.037301821 1.821367069 4.699859269 8.548064381 0.003458898 0.02802827 2.088127439 0.632789083 18.42890427 1.76362E-05 0.000309809 -1.099100727 2.903357434 9.695266799 0.001847433 0.016863044 -0.721756264 4.404760511 8.889740698 0.002867775 0.024118563 1.850932067 6.937759791 35.18675876 2.99553E-09 1.18741E-07 0.625676407 5.654083418 8.631000397 0.0033049 0.027035123 -0.957058281 2.05726629 7.226102937 0.007185101 0.049588732

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1.275404698 3.505349081 12.42834613 0.000422866 0.004868623 -0.628351812 6.401355784 8.625776755 0.003314391 0.027101237 1.423471136 2.901997851 13.60249872 0.000225885 0.002858604 -0.861572728 3.880850534 8.926649558 0.002810394 0.023735951 -0.910300135 4.950772273 10.89957751 0.000961862 0.009841364 3.512425619 -0.925095656 12.27287681 0.000459589 0.005218528 2.693977607 -0.497665751 19.39605594 1.06226E-05 0.000197106 3.429701321 -2.218649168 12.93405208 0.000322659 0.003877392 -0.650632048 6.327173168 8.776343771 0.003051623 0.025361805 1.373450447 -0.494556093 7.868124606 0.005031381 0.037385692 1.176241811 2.827123275 10.46571516 0.001216105 0.011917378 -0.82173338 3.910226763 8.406687718 0.003738432 0.029865177 1.559652902 4.07436192 20.96569041 4.67582E-06 9.47621E-05 1.871771731 0.724899684 12.68008486 0.000369571 0.004348668 1.167979101 3.49199821 10.1707414 0.001426869 0.013559889 1.643361812 5.308807642 23.67890475 1.13823E-06 2.729E-05 -1.19275639 6.668097219 30.47455081 3.38275E-08 1.10051E-06 -1.099574127 3.743068912 11.42185342 0.000725852 0.007752514 2.625874281 4.381418672 10.28417554 0.00134176 0.012950235 1.326657342 7.028250406 21.40680661 3.7145E-06 7.69349E-05 2.299962714 1.178956194 7.472252789 0.00626571 0.044506264 -1.18355903 2.928176607 11.73263837 0.000614135 0.006726237 2.514139592 7.915805615 18.644865 1.57471E-05 0.000280358 2.347730676 0.943021072 14.87424125 0.000114922 0.001596313 -1.126262306 3.615238081 13.57891335 0.000228741 0.00288869 1.059142154 3.347042864 9.210254058 0.002406633 0.020967404 -0.828989801 6.051521877 8.940090372 0.002789789 0.023612336 2.64718113 2.682277955 25.60632821 4.18664E-07 1.09106E-05 -0.701525577 4.336770381 7.623505 0.005761241 0.041635858 0.900352094 5.898543729 14.75720787 0.000122279 0.00167876 2.028900708 0.458140556 13.79427801 0.000203956 0.002621351 1.52017342 6.175541539 16.28859837 5.43902E-05 0.000828205 2.162796984 -0.85487558 8.122423094 0.004372108 0.033636835 3.074099234 5.095313867 16.86249502 4.01879E-05 0.000636952 1.321594667 1.847102696 11.60148493 0.000658992 0.007168399 -0.798107957 6.898539666 13.64796085 0.000220481 0.002800736 2.068039474 6.529776602 54.18922288 1.82083E-13 1.32412E-11 -1.694608334 -0.852898604 7.636052708 0.005721298 0.041422871 -1.099459908 5.975456764 18.83471587 1.42549E-05 0.000257499 -0.930586535 3.447993451 9.607841243 0.001937483 0.017547348 0.712267867 5.043113119 8.039745372 0.004576197 0.034720819 2.795442859 2.617354383 28.37224633 1.0009E-07 2.96819E-06 -1.348339203 2.328529098 9.294697638 0.002298181 0.020165322 -1.750476937 0.128952023 10.45091924 0.001225884 0.011980233 -0.678407041 4.702235388 7.428216443 0.006420895 0.045407688 0.648313296 5.772643873 9.605309784 0.001940155 0.017563512 -0.789441458 7.385073405 9.106013367 0.002547705 0.021902877 4.805685849 3.97932318 161.2359378 6.07599E-37 3.24819E-34 2.849753239 0.160618407 22.26399508 2.37621E-06 5.22818E-05 3.88911286 0.538289249 44.54099722 2.49086E-11 1.38009E-09 -2.796910304 -0.343971572 9.348549476 0.00223162 0.019706004

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2.935580776 -1.675374016 12.40101602 0.0004291 0.004937524 2.175871302 7.462954393 22.43309847 2.17592E-06 4.89087E-05 1.062151031 3.034124672 10.18990216 0.001412118 0.013435159 1.123342268 4.738036299 8.435926115 0.003678795 0.029460146 -0.899123826 3.810941641 7.497065863 0.00617996 0.044018583 1.639573403 0.281178082 11.44445866 0.000717075 0.007667607 -0.714102885 5.729357442 8.549411421 0.00345634 0.028019016 1.174848799 6.620372413 22.98113662 1.63599E-06 3.80257E-05 -0.831900894 5.105812161 11.21614211 0.000810889 0.008517994 1.428071351 3.338428814 13.75103448 0.000208706 0.002666797 -1.870576877 6.138465507 50.01169139 1.52833E-12 1.02129E-10 0.795462394 6.334819131 8.214871896 0.004154845 0.032393705 4.652397815 -1.913210101 39.17696856 3.87079E-10 1.78057E-08 1.911475707 -0.473513029 10.00881775 0.001557925 0.014584957 -0.69727082 5.926946464 11.9561857 0.000544663 0.006059294 1.685073513 3.192555834 8.470560959 0.003609401 0.029057368 -6.940495668 0.276284963 64.92464921 7.78175E-16 7.73483E-14 -2.061075143 2.051051682 15.13378331 0.000100155 0.001421136 -1.578780075 -0.601039723 8.71625637 0.00315385 0.026036374 3.042499056 2.405166725 57.6861334 3.07463E-14 2.48229E-12 -2.04540029 3.898736461 32.29551402 1.32419E-08 4.66057E-07 2.069602622 4.419228221 32.4304787 1.23534E-08 4.37903E-07 0.793929649 5.196154363 10.39481841 0.001263694 0.012295068 2.695570974 2.212703839 42.19379769 8.26618E-11 4.19244E-09 4.333020898 0.812293577 61.95731776 3.50983E-15 3.17007E-13 1.570994752 4.645399864 39.37188956 3.50304E-10 1.61893E-08 1.833787442 5.149957008 8.371805479 0.003810868 0.030224128 1.217619319 6.401170792 19.21084597 1.17046E-05 0.000215165 -2.474526844 3.81277785 45.9931768 1.18666E-11 6.86317E-10 4.117656272 7.294491421 34.06521838 5.32954E-09 2.01565E-07 3.648837647 0.919741646 46.17523854 1.08135E-11 6.30947E-10 1.474305698 6.780287602 29.14747272 6.70732E-08 2.05691E-06 1.632556351 3.422370225 11.08378903 0.000870857 0.009051785 -0.814626258 6.758242236 12.13555654 0.000494695 0.005566023 2.209637053 -1.252868323 14.65871311 0.000128838 0.001756164 4.384203275 -1.3123405 25.01164432 5.69851E-07 1.45629E-05 -0.969200192 5.17739422 12.66813855 0.00037194 0.004368745 1.380313085 8.409551703 8.840970394 0.002945425 0.024624051 3.004547834 -1.474076471 13.41201661 0.000250017 0.003124034 -0.826328355 6.728704109 7.875492847 0.005010921 0.0372897 2.671139945 1.996407959 14.8479652 0.000116534 0.001613042 0.921639089 3.266362361 8.101276379 0.00442341 0.033912809 1.547370449 2.910260966 7.987806217 0.004709344 0.035499555 2.843296843 7.315239662 22.11140675 2.57276E-06 5.59223E-05 3.389985429 2.882111926 54.515701 1.54211E-13 1.13817E-11 -0.858113256 5.974225912 8.514289567 0.003523685 0.028466842 0.786660482 6.289729848 14.91512791 0.000112458 0.001564283 1.634152267 6.217638428 29.70630691 5.0271E-08 1.5859E-06 3.71967441 -1.164524705 18.06629864 2.13344E-05 0.000366952 1.699731266 5.480640425 18.23990226 1.94756E-05 0.000338512 0.795303132 4.463722319 7.435604122 0.006394589 0.045270214

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3.251145297 1.308647597 28.57767642 9.0014E-08 2.70589E-06 1.531424813 4.482753336 10.42739464 0.001241598 0.012115837 -0.691627021 6.079317396 10.27739741 0.001346698 0.012967517 0.877542548 4.412251838 9.153373392 0.0024826 0.021462334 -1.033138234 4.061403413 9.352045254 0.002227368 0.019677237 2.848693755 4.275597907 50.16339374 1.41462E-12 9.48517E-11 1.475992794 6.517143707 19.20534199 1.17384E-05 0.00021547 4.918641484 -2.192886936 13.20514218 0.000279182 0.003419332 -1.44500316 5.170125507 28.7006068 8.44773E-08 2.55655E-06 1.575287115 5.404325372 10.46429074 0.001217043 0.011917378 1.71254967 -1.947781275 7.336426759 0.006757102 0.047239017 1.79252975 -0.187903727 10.07829315 0.001500262 0.014097478 -1.870964341 2.148852305 25.47793022 4.47472E-07 1.16003E-05 -3.419263806 -2.539740528 8.072031673 0.004495369 0.034278485 -0.788804443 5.373255529 10.28272114 0.001342818 0.012950235 -0.675583394 6.554796067 8.948917824 0.00277634 0.023518632 1.936978445 7.774622484 34.11205166 5.2028E-09 1.97907E-07 -0.783484789 6.624070549 8.774737434 0.003054311 0.025373488 0.842813904 6.785925584 9.140094207 0.002500682 0.021609216 1.758254655 3.515494239 15.56582801 7.96818E-05 0.001164897 2.792215149 0.057738558 27.48957735 1.57943E-07 4.54748E-06 1.311588215 0.548395755 8.709330552 0.003165854 0.026124573 1.660754702 5.503797259 22.20280852 2.45315E-06 5.36168E-05 -2.666629043 5.618099349 34.23083072 4.89473E-09 1.87268E-07 -2.633780935 -0.035220052 10.1702043 0.001427285 0.013559889 -1.761270094 9.33982808 11.55146087 0.00067696 0.007313095 -1.726844633 0.790578422 11.45844095 0.0007117 0.007625906 -0.855479064 4.329136661 11.3891582 0.00073874 0.007868755 3.353311017 -0.399747632 16.52930482 4.7904E-05 0.000744922 4.36954731 1.857544387 42.69739355 6.38974E-11 3.29997E-09 4.118050917 -1.88712564 13.91385442 0.000191383 0.002475832 -0.6685152 5.310034655 10.28125428 0.001343886 0.012954219 1.991009225 -0.361197266 15.58502163 7.8877E-05 0.00115655 -0.658171862 6.069270227 7.46017786 0.006307877 0.044752444 2.458240712 4.488470691 39.47669012 3.31999E-10 1.55247E-08 2.30074722 5.021292813 21.36872221 3.78902E-06 7.82327E-05 -0.563307671 6.172668689 7.320923966 0.006815636 0.047527934 -1.119447801 8.159958644 12.06314286 0.000514285 0.005756967 -0.776916446 4.998451103 12.32654657 0.000446562 0.005102826 -0.741172424 4.79217152 7.582892807 0.00589248 0.042444741 -1.88226403 5.019752407 45.35355574 1.64489E-11 9.32262E-10 1.33041289 6.67584981 19.89315743 8.18929E-06 0.000156054 -2.196458133 -0.98714569 13.05235188 0.000302904 0.003664488 1.778609553 -2.057456531 8.080200781 0.004475149 0.034209521 1.310385037 2.194906837 11.46573307 0.000708913 0.00760428 2.396103784 -0.205148791 15.06542783 0.000103848 0.001467223 1.023080271 5.983860084 11.94364921 0.00054834 0.006089927 1.472189814 3.69062673 14.84500247 0.000116717 0.001614448 4.228037148 -1.676982732 33.16679878 8.45825E-09 3.08111E-07 -2.059037663 1.140353667 11.16483317 0.000833625 0.008716758 -0.850096575 6.022293071 14.69207644 0.000126577 0.001732665

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1.948159699 0.913669527 19.55463599 9.77632E-06 0.000182775 1.141370087 4.692076204 13.66339677 0.000218676 0.002779822 -1.433571042 1.915002764 14.33033997 0.000153373 0.002038789 1.248975442 4.996361183 9.326478658 0.00225866 0.019891492 1.260493167 6.132599298 7.944521628 0.004823317 0.036206908 -0.754577461 5.840466043 9.470091667 0.002088489 0.018692452 1.741546714 4.344486955 12.28692079 0.000456144 0.005198728 1.072170589 6.034703081 16.27987761 5.46411E-05 0.000831386 -1.277374672 9.664035044 7.568084951 0.005941088 0.042717089 1.022889261 5.918091339 17.90674464 2.31997E-05 0.000393898 2.547669454 4.504623489 21.01223699 4.56359E-06 9.27727E-05 2.002906459 2.906832763 15.77775109 7.12353E-05 0.001054053 1.961320797 7.964395444 26.41347486 2.75611E-07 7.52982E-06 -0.706355318 4.873352412 7.281881529 0.006965354 0.048342002 3.825480463 1.892036374 51.36467379 7.67065E-13 5.25002E-11 2.256137853 1.598919475 20.79457861 5.11275E-06 0.000101946 1.265277933 1.706260654 9.642928373 0.00190082 0.017270652 0.726344137 5.627492669 12.49939273 0.000407084 0.004719887 0.670929764 4.922969347 7.808651896 0.005199668 0.038434018 1.113514432 7.374372087 15.93390286 6.55932E-05 0.000978457 1.331491953 1.304388674 8.362544103 0.003830339 0.030366377 -1.493247729 2.201264403 10.9605082 0.000930743 0.009578613 2.871800883 -1.524998037 16.32960426 5.32259E-05 0.000814237 1.471097836 0.414020179 9.438384296 0.002124906 0.018958341 1.206513074 2.670672117 10.28684692 0.001339818 0.012940239 0.997402065 6.726155727 20.10487082 7.33097E-06 0.000142122 1.304272238 2.677414886 8.423169235 0.003704695 0.029631566 1.302007534 6.378237364 17.84422529 2.39746E-05 0.000404746 1.497780516 5.88997697 25.11202575 5.40945E-07 1.386E-05 0.919249985 4.331362562 9.535815171 0.002015007 0.018133226 2.127912901 3.554313748 30.80075749 2.85926E-08 9.39472E-07 -1.445402542 3.641399661 16.33713833 5.30147E-05 0.000811634 0.656119965 6.30605555 7.778015269 0.005288587 0.039018369 1.840693793 2.973821633 19.37621122 1.07336E-05 0.000198792 -1.533684139 3.373259617 20.05108901 7.54006E-06 0.000145742 -0.749866741 4.956214962 9.911702629 0.001642311 0.015258297 -3.201966213 4.140508089 122.692872 1.62795E-28 5.19369E-26 1.060820799 4.646060669 12.62286514 0.000381057 0.004465227 1.742103949 5.001260365 13.29904374 0.000265542 0.00328481 -3.871777833 2.14407625 53.29575837 2.86925E-13 2.03419E-11 -0.856799144 5.57631435 10.25662977 0.001361943 0.013070948 -1.144150091 4.16626152 9.411372195 0.002156438 0.01917911 -0.699788519 7.599146044 8.032539196 0.004594439 0.034819155 -1.483318893 4.399599333 28.97478303 7.33267E-08 2.23482E-06 -0.774518395 6.985057559 9.210794906 0.002405922 0.020967404 0.610810004 5.873016656 8.091651699 0.004446962 0.034080163 2.337252832 1.788373724 20.58149267 5.71459E-06 0.000113384 2.089226419 2.208573822 24.90114115 6.03467E-07 1.5402E-05 3.333148987 -2.605960876 8.136490678 0.004338317 0.033454933 1.132161992 1.257878573 9.084036832 0.002578502 0.022107836 -0.74541792 4.288218846 8.00714464 0.004659315 0.035189479

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3.13055909 1.798285171 22.01138226 2.71038E-06 5.85172E-05 0.777350889 5.71133529 10.13870051 0.001451885 0.013740804 -0.742014765 6.754148592 12.11114275 0.000501214 0.005623378 -0.85217412 6.793895472 10.49359442 0.001197891 0.011788202 1.975918398 -0.93883554 11.24015456 0.000800465 0.008421626 3.266395566 4.067982835 47.77210853 4.78755E-12 2.96858E-10 0.97143225 3.53461838 7.686185552 0.005564511 0.040500867 0.98388893 6.988644072 8.867300273 0.002903242 0.024353742 2.767920135 0.248802856 14.59962249 0.000132941 0.001807269 1.508098634 3.227077946 9.766240279 0.001777456 0.01634499 -0.701175497 5.301009821 10.80896241 0.001010099 0.010230291 1.327833761 2.775303901 12.05671227 0.000516062 0.005770329 -0.971270662 6.31976018 15.19214312 9.71066E-05 0.001382843 -1.4349628 1.238640477 10.92379418 0.00094937 0.009734854 1.306130848 4.808925808 14.85420472 0.000116149 0.001609968 2.483952703 6.27251923 68.17452862 1.49646E-16 1.6087E-14 1.862562071 4.617884779 14.5356062 0.000137535 0.001854431 0.86292517 5.484376598 14.07383363 0.000175772 0.002300975 1.827703529 -0.625028861 7.696278677 0.005533479 0.040358489 1.387784923 3.812997595 11.29547635 0.000776962 0.008209563 0.859745666 6.639837743 12.20917968 0.000475549 0.005368931 -0.767641499 5.169401574 10.49635523 0.001196103 0.01177646 -2.096531686 -1.120698374 8.820558903 0.002978554 0.024858988 1.893575463 1.33826939 9.402657858 0.002166711 0.019261819 0.957892829 7.764999144 13.03548578 0.000305644 0.003690865 0.88211852 4.487602601 10.00868286 0.001558039 0.014584957 -0.942334196 4.03293773 7.684606878 0.005569381 0.040500867 -1.393510423 3.827930462 12.38521816 0.000432746 0.004971557 1.138408606 6.235895582 8.156629593 0.004290403 0.033227945 2.302824113 8.529853024 31.52756474 1.96629E-08 6.66844E-07 2.485843247 2.040994048 11.04042247 0.000891465 0.009228571 3.390564184 5.441473814 62.58001697 2.55836E-15 2.36469E-13 1.811401103 3.836076785 29.32055462 6.13416E-08 1.89759E-06 2.972991781 4.730571861 59.22422689 1.40691E-14 1.17918E-12 3.31822585 3.207339687 48.96608867 2.60426E-12 1.67248E-10 1.496227481 -0.024385433 7.376100151 0.006609634 0.046460046 7.105452334 1.857362146 92.30693984 7.42236E-22 1.46814E-19 4.429800967 2.894448498 65.93605488 4.65792E-16 4.79863E-14 -0.965504848 3.360508302 8.43829274 0.00367401 0.029436771 2.695449041 -0.386154298 10.03974773 0.001531982 0.014361422 4.46137221 -0.104402406 16.87088163 4.00107E-05 0.000635162 3.835773135 4.628733372 31.94935645 1.58245E-08 5.4531E-07 1.048782969 4.025778314 8.977055046 0.002733909 0.023198587 1.911227539 2.64532471 13.16335327 0.000285478 0.003485646 1.11291317 2.782157565 7.324734492 0.006801201 0.047452472 0.744943975 6.036442067 8.386374475 0.003780442 0.030071645 1.982323299 -1.168489485 7.575416444 0.005916971 0.042605636 -1.456969831 1.938635143 9.32781305 0.002257016 0.019885866 5.967221328 -1.1035679 30.143954 4.01136E-08 1.28806E-06 1.983113819 6.095192016 32.52579561 1.17621E-08 4.19197E-07 2.739196512 4.490439584 47.12753303 6.65147E-12 4.04819E-10

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4.584465041 2.618594631 88.07773704 6.2932E-21 1.09192E-18 -0.817361692 6.910766792 10.89884074 0.000962245 0.009841364 3.666568867 1.872700182 32.08369119 1.47672E-08 5.15158E-07 1.019521577 5.07537948 13.68121048 0.000216611 0.002755347 1.007025469 3.21052065 8.787941826 0.003032282 0.02523287 -0.745206003 4.960374417 9.033868807 0.00265023 0.022614991 2.25321865 2.092224837 9.249823464 0.002355181 0.02060393 2.728939075 -0.045846649 20.99290234 4.60988E-06 9.35888E-05 2.961476044 2.608665781 30.46492533 3.39958E-08 1.10416E-06 -0.59176002 6.093229426 8.128236263 0.004358112 0.033555258 -2.675115962 -2.274304443 7.905531717 0.004928385 0.036786212 1.485615361 2.270798096 17.63855585 2.67118E-05 0.000445121 1.00091347 5.623255073 20.17855287 7.05394E-06 0.000137601 1.155866948 2.232941013 7.425522927 0.006430513 0.045459455 -0.877908712 5.857153296 11.16725177 0.000832539 0.008714329 2.472761132 3.103615077 36.7111249 1.36995E-09 5.75323E-08 1.521826287 -0.539373882 7.446240301 0.00635691 0.045019575 3.286369912 3.934905088 27.03982639 1.99306E-07 5.63183E-06 -3.089477237 0.48363603 27.12959762 1.90263E-07 5.41495E-06 -1.470534921 1.462281659 13.40093598 0.000251499 0.003140559 0.865489522 5.829195377 11.93479801 0.000550951 0.006112064 -0.919649305 6.90046415 17.22334143 3.32328E-05 0.000539512 -0.895026101 4.529141022 10.47435126 0.001210433 0.011876172 1.837846754 1.951466276 14.86814738 0.000115293 0.001600354 -0.795438481 5.350209934 9.942345142 0.001615196 0.015055884 1.593126871 4.993468892 18.2870777 1.89992E-05 0.000330813 -1.143441058 4.12415428 9.578359612 0.001968842 0.017798767 -1.775501701 4.233021604 38.63089876 5.12019E-10 2.32287E-08 1.645856831 -0.03562912 11.13446258 0.000847385 0.008835673 4.438066384 -0.951576031 23.43708899 1.29066E-06 3.05374E-05 1.351158104 8.003081202 19.20459681 1.1743E-05 0.00021547 -1.794531732 2.781776519 22.31890949 2.30921E-06 5.11093E-05 1.715208155 0.172117305 7.693418737 0.005542254 0.040407591 3.421269026 0.06910905 32.60046967 1.13187E-08 4.04855E-07 -2.223760345 0.93628277 16.93238597 3.87351E-05 0.000617887 2.005224653 1.07736288 20.76077108 5.20381E-06 0.000103657 3.919540711 3.978887845 69.32181284 8.36394E-17 9.45365E-15 1.937490469 3.458570889 23.43174842 1.29425E-06 3.05857E-05 2.350563507 -0.180222473 13.81742512 0.000201459 0.002592623 1.035916786 4.07419473 10.41563045 0.001249532 0.012183445 1.436729357 2.813617824 7.889451215 0.004972395 0.037044811 1.530339659 4.163470862 21.46287972 3.60745E-06 7.519E-05 0.788824377 6.587774441 8.700847944 0.003180621 0.026224542 0.842987986 5.966071506 10.93466924 0.000943813 0.009687923 1.798774525 4.002885799 33.13485274 8.59836E-09 3.12065E-07 2.550071309 2.553726638 12.23180112 0.000469818 0.005313325 3.089575338 0.444379615 17.85961525 2.37815E-05 0.000402049 2.428037183 -1.363566716 10.24796343 0.001368356 0.01310706 4.308520779 3.244287636 72.32543517 1.8248E-17 2.22806E-15 0.658257064 6.180616029 10.26784431 0.001353689 0.013010673 2.327841879 2.889354022 42.91485033 5.7175E-11 2.96053E-09

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0.871184889 4.950686259 10.93274763 0.000944793 0.009692946 -1.067924689 1.702035655 8.026731198 0.004609195 0.03490424 -1.667493145 4.758901088 22.38732437 2.2284E-06 4.97491E-05 -1.459944201 4.765668897 22.63518495 1.95865E-06 4.467E-05 4.615398435 3.556868112 33.94334414 5.67405E-09 2.12562E-07 1.608251379 4.363956128 8.563312374 0.003430048 0.027877286 -2.236323698 -1.223221086 9.920101707 0.001634833 0.015203106 -1.602768033 -0.496328441 8.658834107 0.003254795 0.026735815 1.14150484 5.703647742 18.53703681 1.66635E-05 0.000294815 -0.934124018 5.815470093 15.26352634 9.35047E-05 0.001338295 1.690371629 -1.53673918 7.739614248 0.005402234 0.039635085 1.041489243 5.375939373 18.63832324 1.58012E-05 0.000280831 2.864695912 -2.181390514 12.2103214 0.000475258 0.005368711 0.775950255 4.569791587 7.732058193 0.005424888 0.039771785 1.149727167 6.043160264 19.04980535 1.27351E-05 0.000232166 1.86603041 0.975174438 16.65024302 4.49446E-05 0.000706119 -0.600492691 5.414604346 7.480657635 0.006236529 0.04435762 1.34917227 1.590026083 7.34393192 0.00672895 0.047136676 -1.350399864 4.424072699 20.34139618 6.47837E-06 0.000127251 -1.478756664 0.095293204 11.60084862 0.000659217 0.007168399 -0.699363014 4.938489156 8.905221767 0.002843563 0.023954721 2.223762119 1.73193456 10.11096763 0.001473896 0.013895927 1.863482345 4.893486828 15.34921807 8.93579E-05 0.00128452 -1.131884092 3.6617417 14.53886799 0.000137297 0.001852486 1.546977089 7.955813592 14.67274863 0.000127882 0.001744485 0.580290114 5.786627252 7.862665213 0.005046595 0.037470588 -2.086902327 4.868269669 33.97059817 5.59512E-09 2.10402E-07 2.14303135 2.684505797 38.97062981 4.3023E-10 1.96989E-08 -1.231120934 3.247490832 13.27934544 0.000268346 0.003313288 -1.535232895 2.04366371 17.37497097 3.0684E-05 0.000501181 2.011870587 4.534764107 8.468136639 0.003614215 0.029074855 1.105161343 3.396993333 12.28641007 0.000456269 0.005198728 -1.021837684 5.990102845 14.19922132 0.000164439 0.002169843 -2.087095218 -0.16099818 12.81100326 0.000344587 0.004103507 -0.745587584 4.770523915 8.296188408 0.003972837 0.031245615 -3.162958568 4.001383437 97.57328238 5.18995E-23 1.14064E-20 -0.910081603 3.904151969 11.14772284 0.000841349 0.008781995 2.553923718 1.864963683 18.48171874 1.71542E-05 0.000302955 1.315578028 4.612528409 15.91236701 6.63438E-05 0.000988163 2.304631536 0.613117215 12.57394158 0.000391163 0.004562027 3.199118077 0.311238228 22.58163263 2.01401E-06 4.56847E-05 4.51046747 2.835023799 58.94758655 1.61928E-14 1.35145E-12 4.31946244 -1.219716491 22.94769922 1.66469E-06 3.85569E-05 1.293358591 7.00727078 15.01176002 0.000106843 0.001500966 1.133348555 7.213241954 13.60555596 0.000225517 0.00285578 1.37946553 4.110425348 18.37347363 1.81568E-05 0.000317825 1.053410675 7.52319155 15.34086501 8.97539E-05 0.001287405 3.921661381 8.134482848 40.43766654 2.0299E-10 9.74548E-09 2.749339115 1.953073899 28.48932064 9.42167E-08 2.81655E-06 0.880380491 5.349470943 9.982605167 0.001580259 0.014765013 2.408800664 2.39017717 14.94587367 0.00011064 0.001545157

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-0.892881861 6.705954732 12.70609988 0.000364465 0.004298815 2.086221174 4.5516723 26.63693866 2.45505E-07 6.78224E-06 5.001621271 1.340758323 56.53186577 5.5295E-14 4.32657E-12 5.290597147 0.982187266 71.68081234 2.52981E-17 3.0327E-15 1.33988007 3.095642214 9.345334238 0.002235539 0.019714377 2.236171442 4.401559408 24.25919164 8.42043E-07 2.08456E-05 1.042902946 3.858593398 9.221945959 0.002391312 0.02085545 0.806759368 4.542433508 9.103732537 0.002550884 0.021918544 2.480519004 4.680217734 16.6582052 4.47563E-05 0.00070372 1.760021326 2.318519895 15.12346687 0.000100704 0.001426876 5.355420458 -0.767095969 39.09692767 4.03278E-10 1.85078E-08 1.589304525 1.746989539 11.01323526 0.000904636 0.00934397 2.912942395 1.645310548 47.80455711 4.70896E-12 2.92903E-10 1.852435601 4.139922113 28.09800632 1.15325E-07 3.38445E-06 3.922555907 0.691647849 62.50450178 2.65836E-15 2.43437E-13 1.571614285 2.438115046 16.08459924 6.05747E-05 0.00090977 -0.819351548 4.280670501 8.081030689 0.0044731 0.034209521 3.92917033 1.186912006 45.87645895 1.2595E-11 7.24215E-10 0.80943754 5.311797051 9.913213484 0.001640963 0.015252941 -1.243282039 6.366812935 27.82811704 1.32585E-07 3.86805E-06 -0.910994751 4.951572428 13.05609856 0.000302298 0.003661643 -0.578443651 5.060359975 7.421785243 0.006443885 0.045521444 -0.806322379 4.689808701 9.69841687 0.001844268 0.016849712 1.426151415 1.503719553 8.401485011 0.003749146 0.02993868 5.182010182 -2.264780273 15.00864121 0.00010702 0.001502382 3.492477751 -1.695151662 15.1738432 9.80523E-05 0.001395305 5.473522834 -1.744560949 16.56770462 4.69437E-05 0.000731138 -1.070528926 5.579215932 10.32554959 0.001312012 0.01270891 2.05297697 -1.697673377 11.18249276 0.000825728 0.008650896 2.203824633 3.453364276 16.22880316 5.61341E-05 0.000850178 2.516433329 3.604173395 33.62883585 6.66966E-09 2.47516E-07 1.095886505 4.864332865 13.16358024 0.000285443 0.003485646 0.921762342 4.826897093 12.36725743 0.000436929 0.005007216 3.019598901 2.991280941 38.20608315 6.36537E-10 2.82937E-08 -1.176810358 5.351751611 16.98175787 3.77407E-05 0.000604462 -0.723506518 4.890468542 8.633882326 0.003299676 0.027003556 -0.930511613 7.309753808 8.581474731 0.003396002 0.027677348 -0.828568086 6.508132706 12.12968443 0.000496255 0.005577231 1.615296711 3.597480614 20.88045138 4.88858E-06 9.81687E-05 -0.844261263 4.97580938 10.57378174 0.001147028 0.011349785 3.824867145 -0.838612071 14.4883306 0.00014103 0.001889962 -1.164246326 4.521041265 23.80170903 1.06788E-06 2.57593E-05 0.939509346 2.312169816 7.548258716 0.006006809 0.043069276 0.897558539 4.013175495 7.721437247 0.005456894 0.039888159 2.13180184 6.008037122 42.08318677 8.7472E-11 4.41377E-09 -1.245902041 1.69894723 10.62583561 0.001115186 0.011085642 2.545982946 2.086334139 20.10518575 7.32977E-06 0.000142122 1.068106373 6.531288392 7.284763392 0.006954189 0.048281452 -1.206484535 6.382934533 19.18266334 1.18787E-05 0.000217557 -1.125123473 4.320538859 16.37199563 5.20486E-05 0.000800561 -1.343020404 5.665967283 37.46938508 9.28592E-10 4.01916E-08

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2.90784663 2.457044936 40.09953531 2.41346E-10 1.14206E-08 4.092544939 1.586413101 26.54287941 2.57753E-07 7.08105E-06 0.83492845 7.45473868 7.449653983 0.006344865 0.044950365 1.335964415 3.156142034 8.74421384 0.00310586 0.025736869 -0.784720219 4.137083179 8.148387032 0.004309948 0.033327119 2.879214842 -2.400971963 9.644795192 0.001898889 0.017261038 -1.116056515 2.700049047 9.392664963 0.002178553 0.019358391 2.152499631 3.506441493 9.310516803 0.002278422 0.020029861 -0.855103563 5.451796699 13.27488686 0.000268985 0.003315527 1.242165247 7.282073195 12.28225921 0.000457284 0.005203394 -1.086426383 4.577913539 15.03257537 0.000105671 0.001487672 3.842831332 2.402453035 62.53425041 2.61851E-15 2.40903E-13 -0.708705156 5.354596324 8.183028079 0.004228412 0.032824955 2.346646259 2.591210677 21.96497303 2.77672E-06 5.98296E-05 0.72790063 5.730926198 7.68529314 0.005567264 0.040500867 -1.649653826 1.412787893 15.75822846 7.19742E-05 0.001062425 2.278382415 4.853069461 17.84364268 2.39819E-05 0.000404746 2.432077833 -0.0020099 17.78551784 2.47258E-05 0.000415881 -1.116935244 5.110330766 17.98341296 2.22838E-05 0.000380634 -1.072332648 2.588498307 8.544446552 0.00346578 0.02806104 2.221368694 1.951560768 22.32940542 2.29663E-06 5.09846E-05 0.806854743 5.194374755 9.709790709 0.001832889 0.016768983 4.000425136 -2.223163733 17.57150127 2.76704E-05 0.000459415 1.089545616 6.139862341 17.87040276 2.3647E-05 0.000400118 1.028843276 4.567415244 14.26387342 0.000158885 0.002106402 3.18237956 -0.043606386 18.88628016 1.38747E-05 0.00025132 -2.147504178 3.060790161 19.96714381 7.87844E-06 0.00015115 5.186995977 -0.101657672 57.58742955 3.23285E-14 2.5889E-12 -0.987275443 4.111324248 7.230705743 0.007166703 0.049513581 1.587076677 -0.785523407 8.915250927 0.00282799 0.023854001 2.387070009 0.28597472 14.56541119 0.000135377 0.001832823 2.167382862 1.809849495 18.89784278 1.37909E-05 0.00025003 0.832918698 4.80879532 7.319977849 0.006819225 0.047527934 6.414248935 0.825637894 91.79564873 9.61056E-22 1.8456E-19 3.110750916 -1.010085035 16.25477373 5.53699E-05 0.000841267 -0.92468756 3.215150787 7.337526461 0.00675297 0.047232583 -1.928134795 -0.739981279 9.887291128 0.001664242 0.015433054 -1.180827189 4.838671175 26.32115363 2.89105E-07 7.85507E-06 -1.476052278 2.814044646 13.8711703 0.000195779 0.002522804 -3.708635664 -1.55600956 10.2048605 0.00140071 0.013352309 -0.959435649 7.461600317 12.924797 0.000324258 0.003894244 3.594339913 3.899579294 26.70014882 2.37603E-07 6.58234E-06 -1.991911203 -1.288761488 10.13951491 0.001451243 0.013740804 2.418498379 1.838447575 28.26969257 1.05535E-07 3.12032E-06 -0.730824675 4.248291059 8.585419388 0.003388653 0.027628839 3.018845195 0.316157973 36.79214962 1.31418E-09 5.56629E-08 1.389028599 1.016199929 9.815013258 0.00173093 0.015976575 -0.85868498 4.516412689 9.2941018 0.002298928 0.020165322 0.638919601 5.356963935 8.143221849 0.004322242 0.033359682 1.427624546 6.062877878 14.52272603 0.000138479 0.001863342 1.472847213 2.731540179 19.59444406 9.57472E-06 0.000179445

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-1.102207728 4.797912126 14.91689215 0.000112352 0.001563921 -0.81385688 4.764317808 10.68489887 0.001080136 0.010812296 -0.753524932 5.114699306 7.31882194 0.006823613 0.047541761 3.348652388 4.35986638 60.88812371 6.04122E-15 5.26411E-13 13.51755463 4.316507118 465.1403919 3.6582E-103 9.0449E-100 -2.378198805 1.864205466 27.083702 1.94834E-07 5.53148E-06 -1.375110908 4.380800012 21.84610868 2.95415E-06 6.31709E-05 1.133705838 5.63539742 18.15670975 2.03451E-05 0.000352697 -0.872442948 8.164135075 8.066726885 0.004508549 0.034322589 4.092496358 1.94379786 35.89537316 2.08203E-09 8.45636E-08 1.287904788 5.833455485 12.56210065 0.000393649 0.004582918 3.052027484 1.076745547 22.1389586 2.5361E-06 5.51861E-05 -0.856957913 4.862067289 9.552787222 0.00199646 0.017982689 2.159238124 4.226760839 22.27704004 2.36012E-06 5.19857E-05 2.210345297 0.134827102 10.5578613 0.00115695 0.011441007 -1.435726481 4.021984714 16.5079593 4.84463E-05 0.000752172 0.89897912 7.778504052 9.368053347 0.002207999 0.019549784 1.567713305 -0.732714481 8.078477465 0.004479406 0.034209521 -0.744963422 6.28524032 7.631190957 0.005736741 0.041489117 -1.05057244 4.368112035 12.99198795 0.000312827 0.003766106 2.60212221 1.344159578 20.56177163 5.77376E-06 0.000114434 2.315010733 1.300318837 15.76313971 7.17876E-05 0.001060462 2.529844844 1.178345319 16.36056276 5.23635E-05 0.000804154 1.823700023 0.595975253 17.345714 3.116E-05 0.000507698 4.089966094 3.123691533 34.61429291 4.01944E-09 1.56505E-07 -3.689638477 -1.701880169 9.464350901 0.002095036 0.018734088 3.650138756 -0.689326339 25.68041572 4.02895E-07 1.05553E-05 1.184423964 3.235243461 7.91295642 0.004908199 0.036690923 3.965150331 -0.465680638 29.69258142 5.06282E-08 1.59463E-06 3.017361126 2.603124046 38.36791329 5.85878E-10 2.62187E-08 -1.016283861 5.117010361 19.31963637 1.10563E-05 0.000204006 1.705811782 2.26282457 13.74922985 0.000208906 0.002667232 -1.556163033 2.315137473 15.60248817 7.81517E-05 0.001146766 1.940916815 0.538298656 21.68026451 3.22088E-06 6.82109E-05 -1.663892029 6.117975185 64.538501 9.46644E-16 9.22395E-14 0.699989066 5.045488019 10.47130617 0.00121243 0.011889865 6.013628041 1.595110627 92.17777965 7.92294E-22 1.54737E-19 2.549627943 5.111442223 49.28366526 2.21499E-12 1.43648E-10 4.158508029 2.766292061 32.64919131 1.10385E-08 3.96265E-07 -4.026741946 -0.670484039 22.18264244 2.47905E-06 5.4004E-05 3.24888771 -1.160868296 10.8146979 0.001006975 0.010203871 -0.704563905 6.830194894 10.1393827 0.001451348 0.013740804 4.078765561 -1.887159713 28.69942338 8.45289E-08 2.55655E-06 1.703529185 2.409414286 9.427539287 0.002137509 0.019036439 -1.147084085 1.171111712 8.738819935 0.00311506 0.025769927 -0.608043284 6.185019099 7.773328958 0.005302324 0.039075997 -1.272946363 4.264811963 19.15318212 1.20636E-05 0.000220739 -1.168447259 0.210878773 7.388672685 0.006563591 0.046198156 1.01621843 2.10974517 8.03092372 0.004598538 0.034836877 1.818694653 0.899050551 12.09328771 0.000506037 0.005674266 6.555655428 -1.506880244 31.58563647 1.90836E-08 6.4858E-07

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

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1.010812817 5.739572366 11.68245409 0.000630923 0.006891026 1.929856082 7.494918466 20.13902151 7.20124E-06 0.000140335 1.682746335 6.733909036 32.61365635 1.12422E-08 4.02846E-07 -3.498088951 3.904467479 64.45057691 9.89844E-16 9.55078E-14 1.382593618 3.292259969 7.854997742 0.005068042 0.0375875 1.964166001 2.720466057 20.83913601 4.99518E-06 9.98026E-05 -1.259333214 0.748432781 9.02678036 0.002660527 0.022693065 -0.956653489 4.461565709 11.57641052 0.000667938 0.007243314 1.606279277 4.575121797 13.28085877 0.00026813 0.003312682 0.95792371 6.329072614 14.00137694 0.000182677 0.002377202 1.507893773 6.873956753 19.49069632 1.01091E-05 0.000188462 0.851464262 5.979287949 13.27457151 0.00026903 0.003315527 -0.913366317 4.333935926 9.320654682 0.00226585 0.019945936 2.871783694 10.12239664 21.6333549 3.30062E-06 6.95274E-05 3.073980086 3.080338869 18.7196463 1.51414E-05 0.000271284 3.198655555 2.367742645 65.46229359 5.92366E-16 6.07098E-14 1.422716599 2.417237039 14.79804908 0.000119659 0.001647084 2.205390052 5.464778364 14.5314479 0.000137839 0.001857262 -1.722039416 8.294291493 24.74549861 6.54214E-07 1.65902E-05 -0.636426476 5.221319473 9.764394935 0.001779241 0.016353801 1.269782216 5.810209345 20.8435938 4.98356E-06 9.96713E-05 2.697951976 1.176090576 22.52499719 2.07427E-06 4.67301E-05 5.577099718 1.781173893 52.39080466 4.54849E-13 3.14577E-11 1.157197921 4.873772769 7.756302815 0.005352542 0.039344873 2.688054269 6.267292438 66.98746166 2.73239E-16 2.8902E-14 -0.791317372 4.160019708 8.012611689 0.00464527 0.035096804 2.362571303 0.748767508 17.68279502 2.60976E-05 0.000435622 2.670391843 0.416627945 20.88773007 4.87004E-06 9.78958E-05 2.086717897 4.47480378 47.62997035 5.14755E-12 3.18183E-10 2.432762081 2.427437579 33.9584572 5.63014E-09 2.11317E-07 0.666458186 5.644480457 8.702215196 0.003178236 0.026215807 7.771922338 -0.516084313 44.79785177 2.18462E-11 1.21723E-09 -1.496760175 2.670545822 14.57291607 0.000134839 0.001826787 4.82583287 2.189034206 74.32203003 6.63588E-18 8.52323E-16 1.395261299 2.402217641 10.88243869 0.000970803 0.009895154 3.531114489 4.838663441 58.48720803 2.04617E-14 1.67939E-12 2.117800849 0.462693482 15.6683486 7.54767E-05 0.00110916 1.776086693 5.595251154 21.62186801 3.32044E-06 6.98706E-05 -2.177237762 3.170537238 34.76096043 3.72774E-09 1.46009E-07 -2.813668861 -2.043913142 11.06197285 0.000881163 0.009139702 -1.532299364 4.390275362 34.10027745 5.23438E-09 1.98726E-07 0.786145838 4.608215826 8.197111453 0.004195714 0.032648 -1.975878398 3.072478548 30.18284865 3.93171E-08 1.2666E-06 2.093012763 4.493882106 29.44305077 5.75841E-08 1.79372E-06 0.633353483 6.257068127 9.439463307 0.002123656 0.018955741 -0.839594526 6.548019663 14.2418764 0.000160753 0.002126888 6.413211333 1.133704895 82.41677764 1.10214E-19 1.66415E-17 4.63633739 1.973680504 61.86734601 3.67392E-15 3.28824E-13 1.556112718 4.229429451 20.26851848 6.72989E-06 0.00013193 4.966357385 1.556008677 78.9960941 6.22329E-19 8.66877E-17 1.789762766 6.666225351 12.75046726 0.00035592 0.004218156

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-1.999913476 3.396720808 14.86048726 0.000115763 0.00160574 4.180831045 -0.808070047 37.57020946 8.8181E-10 3.8419E-08 0.918144513 5.593174744 15.01756996 0.000106515 0.001497416 -0.579786162 5.398504102 7.502301384 0.00616202 0.043922435 2.337643084 -0.422573532 7.538447894 0.006039605 0.043205563 -1.382480837 1.965931952 8.87161097 0.002896394 0.024321103 6.831114933 0.273669043 82.51120436 1.05073E-19 1.61894E-17 -0.612599425 5.314916784 8.067836968 0.004505787 0.034318241 1.452361383 6.016965057 7.858136032 0.005059252 0.037550473 -2.285841942 0.822638269 23.01991914 1.60332E-06 3.74422E-05 -3.164446707 -0.589731652 9.775070999 0.001768939 0.016278181 0.774144302 5.88323548 13.00286864 0.000311014 0.003746565 1.997346574 -0.795549852 11.05162204 0.000886096 0.009186052 -1.96797807 -0.969799746 8.230211778 0.004119872 0.032178234 -3.000918093 -0.695053592 10.2208003 0.001388656 0.013262971 1.227282102 3.384071543 14.21449647 0.000163109 0.002155176 1.099127046 3.275067067 10.30837535 0.001324278 0.01280891 3.307334094 1.02504495 18.29235512 1.89466E-05 0.000330188 -0.885405238 4.010341505 9.705690368 0.001836983 0.01679867 0.915597479 5.92612371 9.306915983 0.002282904 0.02006035 1.182468774 2.692138688 8.892592384 0.002863299 0.024100449 -1.010003458 4.458932774 8.112547026 0.004395992 0.033781164 3.218477119 -0.93973159 26.73234709 2.33677E-07 6.49175E-06 -0.767258158 7.341442969 7.221369713 0.007204072 0.049675986 -10.43546921 6.267131013 79.86884807 4.00105E-19 5.69358E-17 3.49840476 0.979560167 11.28627842 0.00078082 0.008241531 1.322838576 1.954506732 9.157242482 0.002477356 0.021426367 -0.642132155 5.551742306 8.796895131 0.003017436 0.025127314 -4.165799515 -0.118676602 37.72406091 8.14932E-10 3.58208E-08 1.940392909 0.949057455 13.24307851 0.000273588 0.003361227 -0.94689351 6.426772671 11.13869394 0.000845454 0.00882019 -2.499369052 -1.591938616 9.720384554 0.001822354 0.016688036 3.684512941 -2.272340208 14.93267908 0.000111416 0.001553075 1.490849023 5.387029736 11.74972396 0.000608523 0.00667216 2.040564491 -0.439684135 14.94576788 0.000110646 0.001545157 -5.584192928 -2.180828478 10.51500355 0.001184092 0.011669826 1.705320404 3.201385334 13.78640082 0.000204813 0.002627243 -6.789194227 -1.624502911 20.55614786 5.79075E-06 0.000114656 1.150657999 3.841464808 8.220918191 0.004141024 0.032298683 -0.621776165 6.42455876 8.618746716 0.003327207 0.027172648 2.600014871 2.821812364 18.70653674 1.52459E-05 0.000272908 1.537857469 2.494377186 17.23305985 3.30632E-05 0.00053738 -1.020599795 6.611976199 12.62003775 0.000381634 0.004469339 -1.204006106 8.615687949 8.677704303 0.003221265 0.026471384 -1.679680798 6.542796622 34.62552114 3.99632E-09 1.55912E-07 1.062441634 4.942339002 15.9995745 6.33567E-05 0.000946523 -3.549810735 -1.356850753 18.81218001 1.44243E-05 0.000260085 1.200766992 4.66339154 14.9282997 0.000111675 0.001555588 1.433878055 0.568466179 8.889667311 0.00286789 0.024118563 1.820162901 2.765409491 25.1962768 5.17821E-07 1.33366E-05 2.419729383 4.85803092 29.30630375 6.17943E-08 1.90685E-06

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1.602911424 6.069099186 29.46916412 5.68135E-08 1.77531E-06 -3.302048951 -1.556394046 21.37097909 3.78457E-06 7.82223E-05 2.806692084 1.563018945 16.23027444 5.60906E-05 0.000850169 1.842266585 2.095764834 9.816252996 0.001729764 0.015973263 -0.749036098 4.533022989 8.256898491 0.004059743 0.031790068 1.211828702 4.331222166 15.81780668 6.97431E-05 0.001034121 3.219685567 4.600032962 20.87403247 4.90499E-06 9.83983E-05 -2.190128179 -1.26543368 9.437216607 0.002126259 0.018961863 2.776919474 -0.321569628 19.70932398 9.01604E-06 0.000170658 0.784082545 7.014682528 9.931078164 0.001625113 0.015134058 2.098591513 5.665541752 42.33238563 7.70068E-11 3.9461E-09 -1.820068101 1.750703805 20.21676713 6.91442E-06 0.000135012 -0.947983665 5.69824298 18.62375404 1.59224E-05 0.000282716 -1.010214014 5.672047586 18.54220894 1.66183E-05 0.000294279 0.870108037 5.177349873 11.5606212 0.000673633 0.007289097 -0.662673281 5.914950282 9.037141531 0.00264549 0.022594035 0.808600278 4.96821855 8.114038298 0.004392377 0.033766504 0.871304295 5.223322852 18.08596711 2.11152E-05 0.000363814 0.900690763 5.671398687 9.200496252 0.002419495 0.021017838 1.98336378 -0.323214672 14.5518385 0.000136356 0.001843245 2.194538178 0.321211566 19.01931336 1.29402E-05 0.000235609 -1.135840545 4.548968093 17.76469631 2.49979E-05 0.000419744 2.121145898 -1.321849303 7.527464795 0.006076536 0.043454042 3.853320323 0.419849755 42.13341899 8.52537E-11 4.31284E-09 -1.997819284 -2.191298662 7.358274126 0.006675484 0.046823074 0.712755443 5.894322569 8.593650945 0.00337337 0.027526145 1.354744096 5.494913228 19.34442803 1.09137E-05 0.00020194 4.327169422 -0.349242042 41.68610597 1.07168E-10 5.3395E-09 2.054689736 1.403590939 11.35065368 0.000754214 0.008006861 2.806446516 -1.952592781 12.23246715 0.000469651 0.005313325 2.69888224 4.475581537 30.88579013 2.73668E-08 9.04892E-07 -0.885978386 5.297610142 8.229846686 0.004120701 0.032178234 1.595475551 1.149939887 10.69938049 0.001071714 0.010738858 0.923458139 6.259269261 8.282485742 0.004002929 0.031432291 0.665944065 6.967024494 9.356972593 0.002221388 0.019638878 1.084801908 3.305954819 7.397871389 0.00653011 0.045999139 -1.693069387 0.318678272 10.5216178 0.001179861 0.011645539 -1.183626949 2.782861011 8.222139232 0.004138239 0.032298683 -1.356905374 0.613723629 10.81798192 0.00100519 0.010191008 -4.522175348 -2.279302397 11.04014789 0.000891597 0.009228571 1.471266606 0.342532626 8.074569835 0.004489076 0.034270138 2.612061478 1.269363527 18.04734679 2.15479E-05 0.000369659 2.261765606 -1.866546377 7.879308177 0.005000361 0.037225115 1.362971378 6.750479719 17.02169307 3.69552E-05 0.000592361 1.60071914 -1.183964466 7.23776259 0.007138588 0.049353819 4.126359744 3.786106979 137.7507244 8.26239E-32 3.40479E-29 0.620456758 6.185766353 8.440579752 0.003669392 0.029432516 1.584201615 5.039466435 16.43315455 5.0396E-05 0.000779385 1.09785343 4.73411915 9.56392 0.001984389 0.01791475 3.98111818 2.971541206 74.14952497 7.24185E-18 9.24154E-16 2.538650311 5.289950265 47.38789417 5.82413E-12 3.5666E-10

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-0.750684529 5.618224789 10.76868036 0.001032321 0.010414997 -2.072246541 -0.07971098 18.09246027 2.10433E-05 0.000362892 -2.008099207 2.192036091 9.202433002 0.002416937 0.02101554 2.330478908 -1.425763241 9.937469086 0.001619481 0.015088708 0.993295864 6.610784691 15.15073951 9.92594E-05 0.001409441 -5.52030767 -1.097798656 36.53451044 1.49987E-09 6.24294E-08 3.13769351 5.202419688 41.7257845 1.05015E-10 5.24544E-09 -1.076572317 4.450638315 14.54481908 0.000136864 0.001847904 1.280236581 3.821295076 8.333547578 0.003891958 0.030731709 -3.995574912 -0.164525937 46.28641086 1.0217E-11 6.01466E-10 -0.73655667 5.710624996 9.560739582 0.00198783 0.017937627 2.081627574 4.566114718 14.9991918 0.000107557 0.001507783 1.671866134 1.154695053 8.922266251 0.002817147 0.02378283 0.63348084 6.153593127 9.034503109 0.002649311 0.022614991 4.061280137 -1.902759311 24.51861733 7.35953E-07 1.84268E-05 2.374870602 1.481646694 21.67005619 3.23807E-06 6.85015E-05 1.94349074 1.630991669 10.48239331 0.001205175 0.01184221 5.068998716 -0.532224298 46.78337872 7.9283E-12 4.75217E-10 -9.299274376 0.908791111 103.151973 3.104E-24 7.30919E-22 4.980387605 0.639551257 33.21475745 8.25219E-09 3.01159E-07 1.637046536 1.040597335 17.61695323 2.70169E-05 0.000449827 1.398016733 4.599223963 20.27833651 6.69544E-06 0.000131385 -4.332646774 1.793214122 76.46360628 2.24309E-18 3.01825E-16 -1.089906864 3.351236211 9.094510358 0.002563778 0.022000667 -2.060457116 -0.846443305 10.78879127 0.001021165 0.010326509 3.864391458 -0.912871651 35.77849366 2.21075E-09 8.94246E-08 -0.767008164 5.135317682 11.70415677 0.000623606 0.00681488 -1.464841008 0.382845401 10.76774046 0.001032845 0.010414997 -1.044849647 4.086253713 7.50993155 0.00613597 0.043784089 1.297005702 3.514951583 17.58804978 2.74307E-05 0.000456332 -0.893291423 5.953666091 11.10954988 0.000858843 0.008941011 2.204623213 2.359893131 17.38036241 3.05971E-05 0.000500588 0.617996375 5.939798064 8.578799275 0.003400996 0.027706629 3.187683209 -0.192956104 33.69933907 6.43225E-09 2.39604E-07 -2.472054486 0.680132574 16.25443504 5.53798E-05 0.000841267 11.02510241 4.799820151 471.724364 1.3506E-104 4.4526E-101 6.938883766 1.434859063 90.30701367 2.03928E-21 3.73491E-19 2.193626009 -0.820511104 16.43860122 5.02514E-05 0.000777757 0.818847999 6.042538176 7.32943383 0.006783442 0.047361976 2.41544116 -0.729797773 14.02849787 0.000180061 0.002349344 1.201863994 7.011452225 14.73281943 0.000123871 0.001697971 -0.857913542 6.122986227 8.947232776 0.002778902 0.02353026 3.312986013 1.846520587 36.91736305 1.23244E-09 5.23124E-08 4.368170157 -1.092371568 18.00618935 2.20188E-05 0.000376758 -2.616135225 0.548355155 24.89119827 6.06587E-07 1.54617E-05 -2.022292975 -1.651867845 9.093282187 0.002565501 0.022005898 6.087771078 -1.202807174 34.94315149 3.39473E-09 1.34028E-07 1.333261433 1.821500085 7.921878772 0.004884053 0.03655186 2.123493778 -0.495898093 12.72223735 0.000361333 0.004266968 2.816162779 -0.644773366 11.03153872 0.000895748 0.009261834 -2.532721938 -1.351843711 16.89986068 3.94045E-05 0.000627553

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1.926727077 1.541275268 17.13852924 3.47502E-05 0.000559738 0.84373393 6.508835194 14.10111695 0.000173241 0.002272351 5.669740263 -1.074255494 21.52070061 3.5003E-06 7.3188E-05 -1.010973366 3.130608695 10.0798338 0.001499009 0.014097478 -1.408671918 -0.327754008 8.915483923 0.002827629 0.023854001 5.947123662 -2.679470217 21.27667694 3.97539E-06 8.16544E-05 2.695573728 -1.252357697 14.069218 0.000176204 0.002305103 -0.962143087 3.9581325 9.168490235 0.002462176 0.021322557 -1.835956444 -0.236009241 7.343914635 0.006729015 0.047136676 -0.69105173 5.281897395 7.32037118 0.006817733 0.047527934 1.182456298 5.687695104 27.78061888 1.35881E-07 3.94672E-06 -0.623378648 5.09770031 8.692792193 0.003194708 0.026307617 3.08707903 5.184614722 57.91603217 2.73549E-14 2.22666E-12 1.34007411 -0.652331422 7.892213909 0.004964806 0.037002206 2.064883272 1.772512956 15.68935419 7.46431E-05 0.001097726 -0.733903339 7.39537098 7.864502211 0.00504147 0.037446596 0.639667259 7.142943768 7.295353205 0.006913318 0.048065176 1.678814145 6.524304381 20.00133775 7.7388E-06 0.000148904 1.320168027 4.129903001 18.90922109 1.37088E-05 0.000248771 3.521906862 -2.223195468 13.59324265 0.000227001 0.002870897 -0.608908166 5.969804542 7.97529584 0.004742001 0.035718496 -1.981974003 0.128404018 16.31373798 5.36734E-05 0.000819815 4.37145562 0.004333902 37.21522206 1.05785E-09 4.54875E-08 1.428588739 5.642865709 26.39190789 2.78706E-07 7.60386E-06 1.540308527 2.387307306 13.368073 0.000255944 0.003182009 -1.143889104 4.665910421 15.07026434 0.000103582 0.001464515 3.322301891 0.605574251 37.58262095 8.76217E-10 3.82595E-08 1.940751235 -0.342920328 10.09026899 0.001490543 0.0140395 5.608895593 5.44431897 259.6227716 2.07369E-58 2.27875E-55 1.541741674 4.140696345 9.993284749 0.001571121 0.01469351 2.189480382 1.261473106 12.77737621 0.000350837 0.004162897 -2.133407468 4.017924736 42.02841369 8.99568E-11 4.5161E-09 1.956111649 0.064687183 12.57516575 0.000390907 0.00456173 1.338323151 0.114186949 8.47532874 0.003599953 0.029004918 -1.848193677 2.354892293 24.34652954 8.04716E-07 1.99715E-05 3.2169656 1.745773871 48.87726118 2.72492E-12 1.73867E-10 3.179179542 2.958623161 59.70990963 1.09922E-14 9.29167E-13 4.459490559 4.956151037 256.6206471 9.35734E-58 9.74149E-55 -0.799723862 5.192354165 8.873327537 0.002893672 0.024314713 2.206329325 1.079452263 25.55422781 4.30123E-07 1.11945E-05 -5.031598381 0.873758312 80.48971725 2.92222E-19 4.18851E-17 2.804975283 -1.847947421 13.52187765 0.000235798 0.00296321 -3.448087046 -0.629515462 32.36683838 1.27646E-08 4.50061E-07 3.384841486 -1.621324751 20.10356014 7.336E-06 0.000142122 -2.850968525 -1.494917303 7.241417994 0.007124069 0.049270662 -6.660716412 -0.458864148 52.35919047 4.6223E-13 3.18568E-11 0.714697671 5.8824169 7.768323879 0.005317036 0.039155242 4.637198292 0.352612152 71.03567923 3.50823E-17 4.10608E-15 2.749579461 0.210713362 33.41097799 7.46017E-09 2.74279E-07 3.481510038 -1.336785926 26.74911961 2.31657E-07 6.45378E-06 -1.907191665 1.974515676 26.9496211 2.08828E-07 5.88407E-06

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7.169382454 2.807534314 165.152922 8.47041E-38 4.65402E-35 2.093373949 2.223646761 17.07571573 3.59187E-05 0.000576242 5.137523566 -0.178871025 61.52742689 4.36619E-15 3.87279E-13 0.937468929 5.718726135 9.555372814 0.00199365 0.017973747 -4.317026161 -2.062436793 20.117263 7.28363E-06 0.000141801 6.185975588 0.544523601 91.21099401 1.29141E-21 2.3934E-19 6.369706561 -2.046656093 30.86143089 2.77125E-08 9.13589E-07 -0.65628733 6.579423039 8.199467367 0.004190269 0.032631307 7.40777409 5.907654685 504.5997159 9.488E-112 3.7534E-108 -0.771498427 5.680325918 10.26953105 0.001352452 0.013010673 2.000819131 5.325941632 48.8928932 2.70328E-12 1.73045E-10 -0.683617899 4.541303033 7.568737422 0.005938937 0.042717089 -0.952932322 7.658879993 12.64597727 0.000376375 0.004412976 4.34245343 4.192379399 106.3773167 6.09514E-25 1.50702E-22 3.121359783 -2.003318681 14.99962455 0.000107533 0.001507783 -2.018298161 0.501538261 15.30829678 9.13146E-05 0.001308842 1.463597202 -0.123614281 8.018933298 0.004629083 0.035028025 2.834191684 -1.088967329 22.01582051 2.70412E-06 5.84563E-05 -2.655620727 -2.1126444 7.315719317 0.006835403 0.04760714 -1.442190793 1.884536031 8.19143928 0.004208852 0.032711627 1.430028792 3.553528063 9.289041122 0.002305288 0.020212144 7.681064866 1.000690189 32.94420676 9.48419E-09 3.42957E-07 -3.752124293 2.226005372 69.24055602 8.71573E-17 9.79529E-15 -1.514279395 8.19790627 17.67464839 2.62097E-05 0.000437122 1.92500469 1.758271851 9.827732612 0.001719001 0.015903575 2.368389214 0.98394088 13.72288198 0.000211858 0.002700092 -1.543444068 7.350253655 29.36344611 5.99988E-08 1.86307E-06 1.13867256 6.332491566 18.09837931 2.0978E-05 0.000362081 -1.358135263 7.584802689 17.47200547 2.9157E-05 0.000479804 -1.624444275 2.762860519 17.07562117 3.59205E-05 0.000576242 0.907446094 7.059072667 15.57218946 7.94141E-05 0.001162329 3.282255396 -1.592418739 17.15139545 3.45156E-05 0.000557321 1.034719793 4.209430882 9.176457068 0.002451481 0.021258351 -2.915501852 7.901579456 55.36723781 9.99892E-14 7.60687E-12 -2.759626822 0.172157602 25.65643876 4.07932E-07 1.06731E-05 4.115017871 -2.839553088 9.526881148 0.002024839 0.018213425 6.448525936 -0.814664832 56.02630963 7.15077E-14 5.54675E-12 1.251867006 6.480981324 20.72135578 5.31203E-06 0.000105706 2.060232152 0.362050592 11.3478615 0.000755349 0.008006861 3.606409184 4.417820364 68.4711019 1.28751E-16 1.39928E-14 1.072176229 1.529340349 7.544742245 0.006018543 0.043126329 -1.57852012 -0.477625883 7.928327581 0.004866676 0.036449394 6.227852187 1.173419061 64.95888793 7.64771E-16 7.67877E-14 3.326129607 -0.08421652 43.43963054 4.37243E-11 2.30133E-09 1.330754015 0.543308959 8.949818353 0.002774972 0.023517113 -1.017872092 8.272934903 7.451049119 0.006339948 0.044947735 3.547920559 0.001795513 31.16841629 2.36584E-08 7.89146E-07 0.670977275 6.003300336 11.98108158 0.000537434 0.005988981 -0.649858922 5.944032502 8.042662381 0.004568834 0.034704889 1.363825936 1.527867675 7.948190855 0.004813547 0.036161019 2.667102957 1.873394628 41.18061064 1.38793E-10 6.77856E-09

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4.198756421 2.436528281 8.066212519 0.004509829 0.034322589 -2.611608851 0.516420014 22.21854679 2.43312E-06 5.32969E-05 2.819502779 -0.810158587 10.97652253 0.000922734 0.00950319 7.962074454 6.062738466 505.5630857 5.8556E-112 2.8956E-108 2.260456695 0.470904611 10.93735387 0.000942447 0.009678918 1.701564319 -1.341659308 8.848021555 0.002934068 0.024549855 4.055588984 5.30469443 101.1973053 8.32625E-24 1.91415E-21 1.179934143 3.619337244 9.113349991 0.002537507 0.021832056 -1.577596541 1.02837097 10.87645917 0.000973943 0.009914867 -5.958670444 -2.154792106 24.14638054 8.92838E-07 2.20204E-05 -2.018152449 1.891970199 19.96302617 7.89542E-06 0.000151329 1.747601963 2.9632066 14.72340956 0.000124491 0.001705285 2.790917632 0.517352385 16.2531239 5.54181E-05 0.000841267 -1.151467341 4.631516785 16.20162471 5.69453E-05 0.000861145 1.315893992 5.322740893 21.89777783 2.87567E-06 6.16927E-05 2.208676898 0.313648035 17.14469314 3.46376E-05 0.000558835 -2.962684049 2.491065868 37.3767956 9.73738E-10 4.1962E-08 5.621747565 1.391420468 64.52362661 9.53817E-16 9.24829E-14 1.807162081 -1.033128278 10.83743945 0.000994682 0.010100004 -1.440952646 3.260529858 21.74535166 3.11343E-06 6.6219E-05 1.78132858 3.933854546 17.17232207 3.41374E-05 0.000552568 4.091468158 -1.37142957 30.18544429 3.92645E-08 1.2666E-06 3.830441383 1.034918411 43.43864681 4.37462E-11 2.30133E-09 -0.911258544 5.180507395 14.06399143 0.000176694 0.00230999 3.971940266 -2.079394082 14.75558768 0.000122384 0.00167876 2.960602961 0.307497345 28.44698312 9.62997E-08 2.87301E-06 3.968431659 -0.102469781 19.66180525 9.24305E-06 0.000174454 3.35451105 -2.5918663 12.7981493 0.000346962 0.004128755 6.268246229 5.16488109 316.9640722 6.64051E-71 9.3821E-68 -1.269027089 2.592914478 13.2675702 0.000270037 0.003323791 0.686558121 5.287389848 7.697077922 0.00553103 0.040358489 3.446452292 2.715109803 29.07847654 6.95049E-08 2.12489E-06 4.386267288 0.417672153 56.53026978 5.53399E-14 4.32657E-12 1.136273217 6.217840486 24.03240646 9.47279E-07 2.30753E-05 3.556540397 -2.121126741 11.47980025 0.000703567 0.007559236 -0.799311403 5.082012032 7.886330869 0.004980981 0.037094807 -0.996535316 7.260720793 7.330053993 0.006781102 0.047361976 -7.723737478 0.918110446 106.6954724 5.19111E-25 1.29975E-22 2.564673201 2.193654415 20.04984631 7.54496E-06 0.000145742 -1.410266184 2.016624363 11.37194059 0.000745619 0.007933486 2.004071157 -0.52354298 8.398676447 0.003754943 0.029948699 2.262238136 -0.790232112 7.548708907 0.006005309 0.043069276 1.495428099 2.262508583 13.7918005 0.000204226 0.002623105 -2.997776936 -1.984012178 12.32120327 0.000447842 0.005114499 3.351385482 -2.114708678 14.44397193 0.000144391 0.001930969 7.805286228 -0.63762139 66.26128626 3.9494E-16 4.11153E-14 -0.589307471 5.279436008 7.791921279 0.005248036 0.038762565 2.160339108 -1.679677509 9.205825634 0.002412462 0.021002857 -9.851654653 4.516637527 391.4275199 4.04675E-87 7.27678E-84 2.09723399 3.932422749 12.31568766 0.000449167 0.005126675 -3.315759682 -1.957611331 12.07318431 0.000511523 0.005732531

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2.430577823 2.868484285 37.13156141 1.10422E-09 4.72759E-08 6.32374333 -1.849231176 33.27908276 7.98368E-09 2.91899E-07 7.973222506 0.856227093 109.3320915 1.37252E-25 3.66871E-23 1.186783338 4.28166069 16.86663491 4.01003E-05 0.000636074 1.212690152 4.509691298 14.68656865 0.000126948 0.001734134 2.010740724 1.321318709 18.66191824 1.56069E-05 0.000278111 3.023736279 1.091332734 34.39976894 4.48777E-09 1.73714E-07 2.504720359 2.720213343 31.5134667 1.98062E-08 6.69686E-07 1.865149569 1.612249271 15.44581783 8.49046E-05 0.001231241 -0.939551869 5.289383585 14.58324041 0.000134102 0.001819298 1.597385584 2.995393403 22.06838626 2.63107E-06 5.70643E-05 -0.918806341 4.79907846 8.392052823 0.003768651 0.03002171 2.519470972 2.957777482 28.57997531 8.99072E-08 2.70589E-06 -1.304768856 0.673704234 9.105835234 0.002547953 0.021902877 3.029730927 1.407075244 31.84483727 1.66993E-08 5.72465E-07 7.094844932 0.110577676 63.32736791 1.75055E-15 1.65674E-13 -3.81171159 -1.849673461 7.622519362 0.00576439 0.041643404 4.98450755 0.085121159 38.21285937 6.3433E-10 2.82591E-08 -1.565330048 2.938092669 19.31775749 1.10672E-05 0.000204017 1.608926878 1.110226632 10.67139283 0.001088052 0.010869525 -5.077933373 0.942276614 72.14204325 2.00252E-17 2.43005E-15 1.303597136 4.213143724 11.80880252 0.000589513 0.0064745 2.917372588 1.706077683 50.49718055 1.19336E-12 8.05621E-11 1.504987672 2.619294363 8.758093186 0.003082311 0.025563153 5.246051188 -0.605112602 27.78921147 1.35278E-07 3.93501E-06 3.424737961 6.030134012 52.67427865 3.93714E-13 2.74213E-11 8.418026744 -0.119440282 54.68437871 1.41527E-13 1.05241E-11 -0.655917308 5.593937852 9.075650629 0.002590354 0.022199827 2.414656638 -1.321380182 9.458228356 0.00210204 0.018779743 2.479412617 0.466788048 13.71762091 0.000212452 0.002705922 10.17988204 1.37547552 131.8710989 1.59657E-30 5.84816E-28 5.69075724 -2.602650635 15.54951278 8.03724E-05 0.001173258 -2.690657819 -0.952770989 16.02701169 6.24452E-05 0.000935023 2.993042762 1.174002447 21.76531085 3.08121E-06 6.56042E-05 2.764675091 -2.157661942 11.82934998 0.000583043 0.006417696 4.364898088 -0.465386155 45.37865967 1.62394E-11 9.23034E-10 2.200966353 -1.766156275 10.90655425 0.000958246 0.009815695 1.097467492 6.409476336 16.77299529 4.21286E-05 0.00066611 0.876646791 4.573107345 7.327061836 0.0067924 0.047407787 1.293011324 3.993268295 16.05225595 6.16182E-05 0.000924039 3.067050226 4.36897596 88.43997002 5.24012E-21 9.17253E-19 -2.125782337 2.92370107 24.15339743 8.89591E-07 2.19677E-05 -1.467246939 -0.542751552 8.571390583 0.003414862 0.027808143 -1.333063013 3.311307905 11.16697376 0.000832663 0.008714329 7.767577073 1.490344314 122.0551063 2.24515E-28 7.04904E-26 -1.900178225 2.181565395 15.71023297 7.38237E-05 0.001087292 4.163898255 3.232969756 11.06904207 0.00087781 0.009109699 9.952569121 0.58665102 38.83867807 4.60316E-10 2.09794E-08 1.842088561 2.979584898 16.22000362 5.63955E-05 0.000853483 -1.004463462 3.407121118 9.483953812 0.002072768 0.018593808 2.970379484 2.211182715 43.03287736 5.38277E-11 2.80187E-09

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3.475424166 -2.522164734 10.12459213 0.00146304 0.013823695 6.572145941 -1.98414115 32.25688984 1.35077E-08 4.7457E-07 5.922430121 0.631083994 89.64428886 2.85071E-21 5.12609E-19 -0.92840209 3.489717338 9.501690979 0.002052826 0.018440011 0.688477212 5.187657213 9.962224618 0.001597849 0.014915265 -0.762180566 4.803141291 8.388856448 0.003775284 0.030050345 -2.399486702 -0.991795441 9.695308043 0.001847391 0.016863044 2.309233223 3.840877647 42.45837988 7.22024E-11 3.70952E-09 8.666366562 3.211274384 26.028222 3.36463E-07 8.95725E-06 1.469804036 0.736431918 9.237023655 0.002371701 0.020711812 5.970630629 0.095126203 78.66694284 7.35155E-19 1.01688E-16 6.068888162 4.614043575 276.3951818 4.58317E-62 5.33266E-59 5.748822056 5.096868521 192.4410175 9.32239E-44 6.5856E-41 2.176862405 3.954936158 49.39596514 2.09175E-12 1.36551E-10 5.720871088 1.634015496 112.1399394 3.3296E-26 9.02183E-24 2.75769796 -0.747151609 19.91405275 8.10027E-06 0.000154507 1.751779955 2.370359604 13.11673534 0.00029267 0.003562464 2.095838062 1.66814432 16.89717007 3.94604E-05 0.000627937 7.23307828 0.627114665 94.48310578 2.47193E-22 5.20157E-20 1.99602959 -0.709020904 8.034616495 0.004589173 0.034792577 1.520701605 1.251134288 7.873544959 0.005016322 0.037301821 0.832133218 5.839327445 17.18080232 3.39854E-05 0.000550557 1.999491565 1.976666251 14.16446984 0.000167504 0.002204409 -5.045049275 0.13242159 41.15422282 1.40679E-10 6.84335E-09 3.12730746 -2.495610234 10.25190471 0.001365435 0.013091766 -1.133959403 0.381477664 7.343724711 0.006729726 0.047136676 -0.84735539 4.624171173 9.37906551 0.002194774 0.019458822 -4.213502051 5.941821123 94.69701323 2.21874E-22 4.77028E-20 -6.221458519 -2.167209309 19.80889505 8.55835E-06 0.000162617 -2.719300071 -2.264880084 9.160027608 0.002473588 0.02140314 2.377747106 0.153253188 23.5427177 1.22171E-06 2.90101E-05 -0.672728021 5.289878984 7.832723458 0.005130873 0.037982288 -1.113771232 3.449200216 14.28748581 0.000156905 0.002081537 4.563616969 -1.300150245 30.58872965 3.18941E-08 1.04275E-06 -4.888602093 -0.792049722 13.96145172 0.000186598 0.002425032 -3.013248385 -1.752521365 12.01458437 0.000527859 0.005885593 1.313779737 4.270814077 7.828129782 0.00514393 0.03805046 -0.672269913 5.333007692 9.318609144 0.002268381 0.019956603 7.80946913 2.110508475 128.6312514 8.16643E-30 2.78504E-27 -4.05787272 0.569106607 49.12600495 2.40037E-12 1.55161E-10 -1.027182416 4.608062185 16.19059132 5.72779E-05 0.000864193 3.029508426 1.613978243 21.18119493 4.17844E-06 8.53818E-05 3.40450959 -2.229192404 12.13087703 0.000495938 0.005576834 -2.452091273 -2.040612828 8.079552188 0.004476751 0.034209521 -1.052064838 5.205964206 19.81528843 8.52977E-06 0.00016223 4.919199349 2.152961777 113.4986595 1.67795E-26 4.67462E-24 4.106317006 -0.147276415 21.5013116 3.53587E-06 7.37758E-05 -1.320042069 4.245036294 9.071773588 0.002595852 0.022227683 -0.880255003 6.413295319 8.111825558 0.004397742 0.033781487 -2.416824701 4.354496208 46.108891 1.1186E-11 6.5076E-10 -2.063206595 -0.283029064 13.42007534 0.000248946 0.003114577

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6.539836627 -2.187383431 21.91917254 2.84379E-06 6.11414E-05 1.780873144 -1.244312956 7.640395571 0.00570754 0.041353531 5.227269487 -1.390652784 30.31733266 3.66833E-08 1.18756E-06 0.759790067 5.164909609 11.03740092 0.00089292 0.009237421 -1.273671367 2.821834306 14.57903833 0.000134401 0.00182211 1.852471429 1.747712016 10.48650439 0.001202497 0.011821761 2.809161236 -0.296130203 19.5933707 9.5801E-06 0.000179445 -1.490243027 4.29335121 17.69508707 2.59295E-05 0.000433547 -0.756852225 5.220779565 10.12409028 0.001463439 0.013823695 2.957811243 1.018346837 17.88920378 2.34146E-05 0.000396864 -1.455451661 -0.385200151 7.773960042 0.005300472 0.039075997 2.343953131 -0.203692181 21.25976558 4.01062E-06 8.22073E-05 3.56713008 -1.803948927 18.06764286 2.13194E-05 0.000366952 -2.027491002 2.261102827 23.33693654 1.35964E-06 3.20544E-05 2.525813693 8.21762165 26.14505675 3.16707E-07 8.48843E-06 0.94876116 5.972669365 10.11419627 0.001471316 0.013882269 2.813496116 -1.716624385 13.21504063 0.000277711 0.003403428 -0.981274462 5.672291456 12.25666478 0.000463599 0.005258428 4.128407422 -1.158218055 27.2665959 1.77247E-07 5.0664E-06 2.481416276 2.144786494 28.32815454 1.02396E-07 3.03202E-06 3.033132793 1.909194406 29.46325132 5.69871E-08 1.77792E-06 4.458487453 0.954995328 44.40173793 2.6745E-11 1.47358E-09 3.417662423 0.691301367 29.04912427 7.0566E-08 2.15401E-06 3.240570043 0.919659074 24.49220406 7.46111E-07 1.86575E-05 3.408210414 0.596965923 29.57152173 5.38909E-08 1.68932E-06 3.488022077 -0.213178248 21.29945026 3.92844E-06 8.0858E-05 2.806480315 -2.455078409 7.307066595 0.006868396 0.047820088 1.638721625 4.351590949 7.400486598 0.006520624 0.045948677 3.295681904 -1.769415264 12.48179187 0.000410938 0.004758987 13.70595983 8.199313536 252.8932012 6.07729E-57 6.01044E-54 6.466674746 2.375565506 81.20432757 2.03546E-19 2.98232E-17 14.03134822 5.69334305 433.0575876 3.51083E-96 7.71602E-93 5.39975034 9.639486615 15.40786392 8.6627E-05 0.001251176 4.647569886 2.94629069 11.63873064 0.000645927 0.007039355 5.717746304 8.408399808 23.04705337 1.58085E-06 3.70049E-05 3.141424928 5.078890462 19.50592086 1.00288E-05 0.000187142 4.337213856 8.39769 31.01699394 2.55779E-08 8.51736E-07 6.091865534 11.07187921 48.83115639 2.78973E-12 1.7743E-10 8.042795259 8.292389054 18.70175084 1.52842E-05 0.000273347 3.050274505 8.103177634 16.96272438 3.8121E-05 0.000610059 7.090231101 10.18448355 17.53133126 2.82612E-05 0.00046818 5.781134866 10.98980111 24.09856878 9.15283E-07 2.24772E-05 2.914250736 4.533596846 14.65757418 0.000128916 0.001756164 6.467722156 6.781652909 49.99251645 1.54333E-12 1.02785E-10 4.685172582 3.286093822 8.760378921 0.003078451 0.025541845 5.837507183 6.010767868 22.95573876 1.65775E-06 3.8441E-05 4.257058368 4.579578386 22.92417873 1.68519E-06 3.8986E-05 5.956536852 6.816248291 25.07676029 5.50928E-07 1.40975E-05 2.824827662 5.266965619 9.573974686 0.00197355 0.017825035 4.333079448 6.978149154 35.25557677 2.89153E-09 1.15137E-07 4.309366455 6.534851327 26.20361788 3.07246E-07 8.26848E-06

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3.934266616 6.222455185 14.77972221 0.000120828 0.001660858 3.062153687 4.704835985 13.87572757 0.000195305 0.002519977 2.839882063 5.266437726 7.303244937 0.006883019 0.04788819 7.279668731 7.977942775 133.7639739 6.15325E-31 2.43422E-28 4.107304659 6.79437765 10.40522275 0.001256594 0.012244054 3.46662483 9.230310295 8.283860593 0.0039999 0.031420974 3.557541431 8.414645224 18.01206981 2.19509E-05 0.000375921 7.724483422 2.587219454 9.318044866 0.00226908 0.019956603 5.042800302 1.282207427 10.98908597 0.0009165 0.009453105 5.107165847 -1.878587029 12.81889279 0.000343137 0.004088701 7.282705973 8.848158905 28.62524889 8.78295E-08 2.64827E-06 5.149978526 8.091556139 43.96374436 3.34515E-11 1.80292E-09 4.631217676 7.900163212 36.38639036 1.61829E-09 6.65485E-08 6.194930195 3.644096965 16.94179047 3.85436E-05 0.000615329 4.912439279 9.354745195 23.57036475 1.20428E-06 2.86651E-05 5.02810049 6.996765281 26.93838122 2.10046E-07 5.90997E-06 7.449175849 5.944248815 57.08762411 4.1682E-14 3.29788E-12 8.200485832 7.430150109 26.89141 2.15213E-07 6.02963E-06 4.036243076 5.163375989 10.09794398 0.001484348 0.013987809 3.627122453 4.491821932 13.93771533 0.000188969 0.002447804 4.13464434 3.50821681 29.90304538 4.54199E-08 1.44154E-06 3.034262461 4.346799689 17.72483551 2.55272E-05 0.000427905 5.125025134 2.72842389 51.14119451 8.59554E-13 5.8426E-11 4.418425263 4.144725905 46.54151317 8.96979E-12 5.328E-10 4.434778116 3.824741807 49.35992021 2.13054E-12 1.38625E-10 3.395830129 15.11026755 7.6848114 0.00556875 0.040500867 3.899749106 8.017977186 14.14724702 0.000169044 0.002221725 4.090888462 16.34644392 9.982616627 0.00158025 0.014765013 4.592867259 6.507757497 83.47789808 6.44323E-20 1.01958E-17 3.413099377 4.099090188 57.13265994 4.07384E-14 3.23617E-12 3.473065889 5.026230828 72.38797509 1.76788E-17 2.17197E-15 3.176031417 6.846119841 29.96965335 4.38861E-08 1.40237E-06 2.561562538 -1.17493699 12.88603649 0.000331043 0.003961298 6.441408449 5.918435444 49.7399461 1.75535E-12 1.15736E-10 7.523121813 5.439976037 46.84163053 7.69611E-12 4.64113E-10 6.720816608 9.198866792 46.79507686 7.88111E-12 4.73825E-10 5.750129573 -1.603237379 23.21150849 1.45126E-06 3.41331E-05 -3.253711171 2.605293416 15.71144415 7.37764E-05 0.001087292 6.15138082 10.53744557 76.2980198 2.43928E-18 3.26007E-16 3.79267747 6.946045312 13.56203498 0.000230807 0.00290602 7.190844794 5.364729302 70.41881498 4.79603E-17 5.48355E-15 3.329067573 3.776383332 20.25247716 6.78655E-06 0.000132909 -5.277067223 3.485029831 29.66869739 5.12558E-08 1.61183E-06 8.074641075 6.755031991 37.13536174 1.10207E-09 4.72759E-08 4.925203304 6.660717115 20.99152266 4.6132E-06 9.35888E-05 5.186116718 8.339409631 33.14203421 8.56666E-09 3.11486E-07 3.486995722 1.466576131 8.554410272 0.003446861 0.027953637 1.293014535 5.221613485 7.54371123 0.006021988 0.043126329 4.142310739 6.75553627 21.21867686 4.09752E-06 8.38149E-05 2.483468349 4.348485615 15.57139852 7.94473E-05 0.001162329 2.563789915 -0.917440542 13.41246434 0.000249958 0.003124034

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2.236250319 1.962007249 18.25225232 1.93497E-05 0.00033662 2.510974206 0.408817644 11.94870202 0.000546855 0.006076845 2.996115361 0.376204555 22.54367456 2.0542E-06 4.63836E-05 7.372333322 -0.723099265 43.13846472 5.09997E-11 2.66234E-09 4.501925811 -0.813125677 36.60583627 1.44598E-09 6.04683E-08 4.505204546 -1.830251437 22.80216102 1.79564E-06 4.12038E-05 1.761980595 2.520152548 8.178679921 0.004238559 0.032890822 3.692530583 9.533634043 13.38118465 0.000254161 0.003161829 3.262777276 9.083262305 15.24080255 9.46365E-05 0.001351559 3.788014286 7.164381036 22.33558313 2.28925E-06 5.0878E-05 3.502876408 8.504803621 18.11097846 2.08396E-05 0.000360007 -2.267181541 -1.309926914 8.909532978 0.002836858 0.023908416 -2.879652261 -2.171464363 10.1530429 0.001440633 0.013660456 1.720321799 3.497645046 7.90881386 0.004919451 0.036747262 4.747723368 0.762599128 79.63437106 4.5052E-19 6.32005E-17 -5.45867376 0.646779737 54.05978457 1.94481E-13 1.39378E-11 3.709536443 0.891252301 19.59465606 9.57366E-06 0.000179445 3.343916483 -2.522023536 9.337468981 0.002245154 0.019790172 3.968661743 1.466846959 60.38143985 7.81464E-15 6.71395E-13 1.104972798 1.463386667 7.967876817 0.004761476 0.035824263 4.759278214 4.049406278 176.8902204 2.31443E-40 1.30798E-37 1.969455834 -0.688047064 12.54518892 0.000397228 0.00461643 -3.337534855 0.614321001 34.67146647 3.90311E-09 1.52576E-07 -2.071415038 3.970831295 52.66257459 3.96067E-13 2.74884E-11 4.867993347 3.178549838 123.6035545 1.02875E-28 3.33584E-26 -1.823069448 0.379995634 15.41848994 8.61413E-05 0.001246434 -1.319608455 2.928290628 14.78351935 0.000120585 0.001658669 -3.027365136 -0.718789429 8.144500519 0.004319195 0.033359682 9.551617347 0.53039099 108.3822946 2.21629E-25 5.84509E-23 1.049411526 2.493930588 9.010563264 0.002684237 0.022855878 -2.009961271 2.700031467 33.86124332 5.91861E-09 2.20887E-07 3.0360153 -2.089342492 9.168751113 0.002461825 0.021322557 2.597835386 -2.26765036 7.839068144 0.005112896 0.037877557 -1.473099305 1.747223041 13.51349446 0.000236854 0.002974586 -1.697916576 -0.599005579 11.49196533 0.000698977 0.007522178 -2.912485972 3.703699595 69.53171096 7.51958E-17 8.54812E-15 3.480573281 1.998706242 44.07134316 3.16623E-11 1.71583E-09 -1.109999771 2.00518352 9.242314149 0.002364859 0.02066118 4.14598141 2.501577619 82.48562213 1.06442E-19 1.61955E-17 4.893448117 -2.240647691 10.26790661 0.001353643 0.013010673 2.739098304 2.192935364 13.48789138 0.000240108 0.003009717 0.96930598 3.899242182 9.80430789 0.001741035 0.016047382 -1.695276227 2.987996346 24.66822677 6.80976E-07 1.72027E-05 2.75842209 1.069601796 26.296846 2.92766E-07 7.94365E-06 0.622639902 5.689305089 7.729379981 0.00543294 0.039801318 2.74793614 3.579127835 13.27530555 0.000268925 0.003315527 2.330514475 0.24667814 13.99181161 0.000183609 0.002387756 6.69220201 -0.29660527 64.69959867 8.72326E-16 8.54189E-14 3.585979905 4.202266819 64.94838571 7.68858E-16 7.68081E-14 2.075029889 3.668759632 20.10415053 7.33374E-06 0.000142122 3.457402439 -1.236609638 19.67743113 9.16777E-06 0.000173198

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-0.580446637 5.311858059 8.248551541 0.004078453 0.031911315 5.556949992 -0.078053051 65.01457175 7.43463E-16 7.5029E-14 3.047357096 1.474702576 12.37357314 0.000435453 0.004996096 1.73900907 -0.698169431 11.25137543 0.00079564 0.008375607 -1.249130213 1.751823191 9.554196695 0.001994928 0.017977073 3.416463517 -2.057480003 17.40677893 3.01748E-05 0.000495317 2.298850939 -1.880869021 9.43472367 0.002129152 0.018979099 -1.104290491 4.42534587 14.03411179 0.000179524 0.002343887 -1.571339699 -1.62378361 7.789584368 0.005254828 0.038798247 1.302108337 2.054622053 9.424359065 0.002141219 0.019060898 1.027793192 1.705955638 7.474425647 0.006258153 0.044479432 -2.004885628 -0.348028153 8.352800986 0.003850932 0.030480769 -1.145805298 1.616166639 8.314558303 0.003932857 0.030992791 4.057017778 8.550347267 23.63563558 1.16412E-06 2.78431E-05 3.351102461 -0.090008729 25.81074567 3.76586E-07 9.90541E-06 2.617383926 6.280416465 10.80562304 0.001011923 0.010243516 -3.575889508 4.252999047 14.24320728 0.00016064 0.002126807 8.009160019 5.942447163 41.18956102 1.38158E-10 6.76429E-09 5.484429281 6.223037483 46.48021763 9.25481E-12 5.48084E-10 -4.253127147 0.315053143 53.21561162 2.98874E-13 2.08895E-11 4.51409843 8.545667892 11.62069068 0.000652222 0.007100136 3.341689922 -2.147295417 8.689951825 0.003199691 0.026326907 6.711283361 1.691115238 33.34071142 7.73464E-09 2.83317E-07 4.856968393 6.767761969 39.17799212 3.86877E-10 1.78057E-08 5.252412355 7.699453665 41.27215804 1.32442E-10 6.5005E-09 -3.746132248 -0.318186592 29.81897822 4.74326E-08 1.50115E-06 6.343048685 5.426928726 46.39837543 9.64955E-12 5.69755E-10 -7.033186418 -1.023507293 13.76897667 0.000206722 0.002646576 4.547076514 5.689797326 13.94369041 0.000188369 0.002443236 5.106532635 5.560317714 32.047969 1.50412E-08 5.23795E-07 3.715669394 -1.692550592 26.25915081 2.98537E-07 8.08912E-06 2.703755741 6.427534548 7.760395898 0.005340425 0.039295758 6.036187599 10.5483889 45.42362426 1.58708E-11 9.04684E-10 3.89324156 5.852080467 12.33603819 0.000444297 0.005079881 -2.741067177 -1.707775761 8.51878554 0.00351499 0.028412954 4.952378178 1.572300349 18.86127738 1.40578E-05 0.00025417 5.528946437 0.665141176 15.49743803 8.26172E-05 0.001203363 2.851112555 5.25858715 8.013259811 0.004643607 0.035096804 3.14902249 7.875054952 17.51778762 2.84632E-05 0.000470738 7.155547061 4.82574295 327.072167 4.17332E-73 6.34987E-70 4.295687162 7.181863081 10.51519245 0.001183971 0.011669826 4.632175975 7.887336289 22.63362159 1.96024E-06 4.467E-05 2.984723663 -0.01207714 15.4152202 8.62905E-05 0.001247679 8.781077159 8.112531706 91.20594306 1.29471E-21 2.3934E-19 8.266283347 2.503916995 183.2260077 9.57383E-42 5.91782E-39 2.264818789 -0.973622238 16.19614248 5.71103E-05 0.000862322 7.160942228 9.916442952 13.38239944 0.000253997 0.00316177 -8.645189062 -0.139765365 72.5619837 1.61867E-17 2.00108E-15 1.911188309 -1.713478299 10.98881143 0.000916636 0.009453105 4.280819311 5.40796556 36.75227291 1.34134E-09 5.65709E-08 2.970886878 -0.392196872 29.41096264 5.85455E-08 1.8208E-06

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

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3.573120781 2.713479441 13.25051737 0.000272505 0.003349995 2.107673492 0.084275898 8.040953288 0.004573146 0.034720819 3.279436849 4.235385967 32.01962602 1.52623E-08 5.27776E-07 3.091025779 -2.18847501 12.28961827 0.000455485 0.005195785 5.376342826 -2.449737641 16.64631498 4.50377E-05 0.000707021 -5.450903595 -2.101910548 13.523476 0.000235598 0.002962569 1.193214285 1.851446393 11.07072378 0.000877014 0.009106218 6.106919102 9.177573042 27.80984898 1.33843E-07 3.89899E-06 5.117984781 9.730345033 44.10246606 3.11628E-11 1.69341E-09 4.452442195 3.262433223 140.726405 1.84658E-32 7.9403E-30 3.971896679 -0.813007137 34.91918525 3.43678E-09 1.35417E-07 3.486991118 4.231238632 29.27866046 6.26822E-08 1.93124E-06 10.17859612 4.603036527 466.5999801 1.7605E-103 4.9748E-100 5.693675211 6.396878077 75.24966503 4.14801E-18 5.39787E-16 -9.778920289 4.868870826 61.08119424 5.47688E-15 4.81479E-13 6.25072081 9.904758588 15.03555871 0.000105504 0.00148638 6.062027198 8.179419413 29.50828877 5.56781E-08 1.74258E-06 4.90603339 -2.653523902 10.7172429 0.001061417 0.010662687 3.186609825 6.49738524 26.887551 2.15643E-07 6.03314E-06 3.426972961 5.39380722 10.25561017 0.001362696 0.013071832 8.810109921 8.66316722 54.69307676 1.40902E-13 1.05171E-11 4.17012997 6.906921768 9.640076986 0.001903773 0.017275295 10.25087331 7.193483419 101.1885393 8.36318E-24 1.91415E-21 6.925912955 9.030134929 44.47532261 2.57584E-11 1.42319E-09 -2.997301667 -1.757163234 16.57297132 4.68135E-05 0.000729685 4.910700414 7.56599044 24.06106496 9.33284E-07 2.27625E-05 6.877490597 9.083864263 45.2604428 1.72498E-11 9.69323E-10 9.384484883 9.658707353 60.59624032 7.00677E-15 6.07868E-13 3.954683943 3.761045714 14.52645008 0.000138205 0.001860928 2.679452043 -0.847776949 24.69697087 6.70895E-07 1.69914E-05 5.817441505 0.083125236 81.71378562 1.57293E-19 2.33928E-17 2.91138319 -1.344125342 11.08035497 0.000872471 0.0090638 1.024790333 4.562614983 17.50248484 2.86932E-05 0.00047375 8.337409987 4.44720699 85.96387016 1.83253E-20 3.07182E-18 1.910516566 5.336212247 9.201500509 0.002418168 0.02101554 -0.852232617 5.178480502 9.356440299 0.002222033 0.019638878 1.882964844 0.090193912 15.45691591 8.44075E-05 0.00122583 8.602584513 3.569012822 137.5761481 9.02165E-32 3.6418E-29 -1.288463068 0.414674104 8.567534336 0.003422103 0.027855635 1.998945232 0.279089184 9.629240036 0.001915038 0.017359972 -3.099677597 -1.328093936 10.37998939 0.001273884 0.01238203 -1.849567834 0.707030856 17.36038138 3.09205E-05 0.00050421 -1.564765486 0.725369481 13.77658896 0.000205886 0.002639289 2.890995314 -0.613963823 19.23484269 1.15584E-05 0.000212873 -1.212609638 2.351966636 8.80538643 0.003003425 0.025024327 -3.361792585 0.13892454 34.04061931 5.39735E-09 2.0374E-07 -1.676682319 -1.091217868 8.059581702 0.004526363 0.03442194 -1.976723371 -1.096713557 7.408764581 0.006490688 0.045784919 4.477063127 1.169663336 31.87751892 1.64207E-08 5.6389E-07 1.966599149 1.247711105 12.25545213 0.000463901 0.005258428 2.667727244 -1.614878849 10.67852545 0.001083864 0.010844125

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1.687564542 -0.683673477 9.097018275 0.002560265 0.021983288 3.901791113 1.602394778 33.45366771 7.2982E-09 2.68824E-07 -1.897942329 2.532075773 22.61695303 1.97732E-06 4.50074E-05 1.741658398 -1.280412752 8.926817811 0.002810135 0.023735951 -1.284403648 1.953205464 8.014786739 0.004639694 0.035081476 1.503887562 0.969339582 8.449878971 0.003650677 0.029306168 -2.460362646 0.384730263 12.44361036 0.000419424 0.004843089 -5.79583715 -2.236253328 19.71123395 9.00703E-06 0.00017065 7.437852872 -1.356370269 57.56861905 3.26392E-14 2.60324E-12 4.751832332 1.847904892 92.33381409 7.32224E-22 1.46297E-19 -1.965590804 0.778734798 20.90045031 4.83781E-06 9.73467E-05 1.264319705 0.185309789 8.641732676 0.003285488 0.026932017 -1.883958141 2.27383303 27.08018446 1.95188E-07 5.53148E-06 6.808152829 -1.293015949 36.4952323 1.5304E-09 6.32242E-08 -1.364093502 0.98162072 11.55523572 0.000675587 0.007302251 -1.982124309 0.287728463 21.87449102 2.91078E-06 6.23783E-05 3.957052431 -0.78950531 33.93512201 5.69807E-09 2.13058E-07 4.423034004 -0.526875566 46.72730206 8.15844E-12 4.87535E-10 1.959232744 2.058947545 11.89890961 0.000561668 0.006217009 -2.548710045 -1.645694194 8.193940737 0.004203053 0.032692246 -1.538031946 0.980962562 12.12621533 0.000497179 0.005584443 2.532125007 -2.436123506 7.419034995 0.006453742 0.045567234 1.337535628 -0.125676067 8.399939711 0.003752335 0.029939967 7.417521441 -1.007872502 39.42884485 3.40234E-10 1.57977E-08 1.964043397 0.120397802 10.55713543 0.001157404 0.011441007 -2.148575137 -0.981900141 13.94472613 0.000188265 0.002443236 3.339213291 -1.153724901 11.50808856 0.00069294 0.007469402 7.998486509 -0.533103218 71.52896472 2.73218E-17 3.25557E-15 2.70959464 -2.038332457 11.34914692 0.000754826 0.008006861 2.908794008 3.722883091 58.69054368 1.84526E-14 1.52717E-12 0.730666042 4.885006314 7.780109398 0.00528246 0.038987707 -2.512321898 -0.831133669 18.06003938 2.14047E-05 0.000367522 2.121315459 -0.789070704 10.37538665 0.001277064 0.01240684 1.550570987 0.818996754 9.118782437 0.002529983 0.02177679 1.115851297 4.864154398 22.60794291 1.98662E-06 4.51151E-05 3.596631971 -0.868380353 23.63131685 1.16673E-06 2.78719E-05 -4.109079566 0.180980249 33.52523158 7.03455E-09 2.59596E-07 -1.953996916 -0.452344978 15.1103673 0.000101405 0.001435783 -0.810475657 3.988518647 8.464848772 0.003620754 0.029101384 2.14628612 2.558458842 16.35656953 5.2474E-05 0.000805225 3.534175713 2.243120425 54.52975775 1.53112E-13 1.13429E-11 2.660672001 -1.023634695 14.42912344 0.000145534 0.001942419 -1.111456872 3.161058403 10.674075 0.001086475 0.01085926 3.426461354 -0.6704914 27.72413077 1.39907E-07 4.04584E-06 3.473064219 -2.229085872 11.50265003 0.00069497 0.007487208 3.920523494 9.828818509 13.24061638 0.000273948 0.003363555 -5.786668394 -2.083414297 20.66026979 5.48422E-06 0.000109023 -5.871693207 -1.784374765 17.89638057 2.33264E-05 0.000395709 4.282751736 0.232175649 53.21664248 2.98717E-13 2.08895E-11 9.641940973 1.356523298 116.6460294 3.43159E-27 1.01309E-24 4.115109827 -1.894804022 25.98271919 3.44487E-07 9.14625E-06

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2.986260614 -0.761144335 23.59706526 1.18769E-06 2.83041E-05 -2.408388086 -1.755744044 9.599769634 0.001946018 0.017608524 -2.284888368 0.292073064 22.69817254 1.89548E-06 4.33942E-05 -2.884753405 -2.261353508 10.94589395 0.000938113 0.009644423 -1.944249433 -1.405902737 8.555165568 0.003445432 0.027953502 4.600501393 0.868060059 28.56538119 9.05874E-08 2.719E-06 2.450894714 -0.661975404 11.42181533 0.000725867 0.007752514 6.370631059 -2.322640128 29.14065849 6.73095E-08 2.06096E-06 2.803688354 2.205205283 22.45726931 2.14871E-06 4.8352E-05 1.945416375 0.786452247 13.13402722 0.000289981 0.003531909 -1.454042131 2.470086426 10.0254371 0.00154393 0.014466576 -1.235797409 0.461633484 10.22873485 0.001382695 0.013218802 5.207477039 -1.879561813 30.32015471 3.663E-08 1.18756E-06 -3.037347803 -1.8430584 12.86732914 0.000334368 0.003996259 -2.363452081 0.263057297 26.15613859 3.14894E-07 8.46279E-06 3.197118841 -2.401465729 10.88495611 0.000969485 0.009889845 2.753991661 -0.140251542 9.481533579 0.002075504 0.018609913 -1.87959219 0.663927862 15.7556983 7.20705E-05 0.001063054 5.050246729 -1.096598136 42.95570495 5.59934E-11 2.90695E-09 4.560265688 -1.413177273 21.44332358 3.64443E-06 7.58384E-05 3.927939764 -0.260288153 23.690814 1.13121E-06 2.71546E-05 -5.015100091 -2.25717178 9.813123384 0.00173271 0.015985542 1.749145702 1.047339665 16.58425778 4.65357E-05 0.000727074 -1.387461418 0.044534369 7.287971687 0.006941781 0.048212226 3.868595978 2.700937234 93.82722749 3.44303E-22 7.16875E-20 7.170797467 -1.442358703 46.98435833 7.15555E-12 4.3324E-10 9.118921612 0.397162118 106.010784 7.3335E-25 1.76898E-22 3.720150471 -1.844191949 21.38865767 3.74983E-06 7.75854E-05 5.375491357 -2.763846479 12.76472113 0.000353218 0.004188643 -1.486102951 0.987409256 11.1037623 0.000861528 0.008964238 1.828437172 0.32503168 19.33535109 1.09657E-05 0.000202523 1.639360329 -0.737167471 8.123175623 0.004370294 0.033635959 -1.975223666 -0.522453511 12.34031535 0.00044328 0.005071186 3.390441481 -1.398328312 14.39118169 0.000148496 0.001976617 3.134218469 -1.775846418 14.15270412 0.000168555 0.002216763 4.866192667 1.679378071 22.40416926 2.20894E-06 4.93704E-05 3.622494254 1.628754841 46.20353889 1.06584E-11 6.23739E-10 7.028109538 5.438153616 45.33040692 1.66445E-11 9.40651E-10 2.219481677 0.868954679 22.41616969 2.19518E-06 4.91184E-05 -4.184883666 -1.109654767 24.64581317 6.88943E-07 1.73596E-05 7.08778991 -0.993873736 38.48581778 5.5153E-10 2.48503E-08 5.430631459 -0.307441967 67.77053042 1.83674E-16 1.96383E-14 3.54503715 -1.803211331 19.99051257 7.78274E-06 0.000149604 -3.131454368 0.287880657 18.29885689 1.8882E-05 0.000329353 -5.673566132 -0.971486336 41.15238847 1.40811E-10 6.84335E-09 8.564053665 3.113236627 132.3902846 1.22915E-30 4.5873E-28 3.783728254 1.492868468 25.50459463 4.41331E-07 1.14561E-05 5.834189707 -1.602131832 19.63404825 9.3783E-06 0.000176501 3.594518643 1.395260337 22.31396908 2.31516E-06 5.11093E-05 -0.694949773 5.214265869 9.689047386 0.001853696 0.016887474 11.82900314 8.698488221 151.6218965 7.66415E-35 3.8871E-32

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1.088196994 0.967261188 7.666456479 0.005625683 0.040835233 6.995566939 -1.917946498 22.28014146 2.35631E-06 5.19596E-05 1.527499784 0.10369616 10.99688396 0.000912652 0.009421845 6.20088269 -2.245501001 23.89358119 1.01811E-06 2.46188E-05 3.118811956 3.663693423 36.7749121 1.32585E-09 5.60372E-08 3.381469002 0.56692131 26.45991501 2.69064E-07 7.36111E-06 1.76447451 0.19026867 11.47227608 0.000706421 0.007585781 7.643186714 -1.113819872 55.13736407 1.12394E-13 8.48531E-12 9.286182555 3.866187536 81.58460819 1.67917E-19 2.47865E-17 2.322076426 0.859239811 15.01987186 0.000106385 0.001496654 -5.734850688 -2.030090537 20.5436605 5.82865E-06 0.000115291 2.634055274 0.157726227 11.27131408 0.00078714 0.008303801 2.827806447 1.494854156 18.59660091 1.61508E-05 0.000286514 3.595056919 -2.540558235 9.168566507 0.002462073 0.021322557 3.856023721 1.922610365 22.66809104 1.92539E-06 4.39771E-05 6.711656976 1.259088053 106.3067279 6.31617E-25 1.54239E-22 -4.194296472 0.118182005 38.47023876 5.5595E-10 2.49925E-08 4.427933506 0.981826372 60.96802496 5.80094E-15 5.0771E-13 -2.06683375 1.133361365 21.65775785 3.25889E-06 6.8795E-05 4.529546338 -1.292085827 26.1485515 3.16134E-07 8.48458E-06 3.923993594 2.896264596 17.76250737 2.50267E-05 0.000419871 3.467472882 -1.772342769 19.61343521 9.48002E-06 0.000178246 2.250483236 -1.361552595 9.673955001 0.001868985 0.017004845 2.01970214 5.440581179 10.07903914 0.001499655 0.014097478 2.387483599 -2.071137606 9.096749349 0.002560642 0.021983288 13.13763862 6.072727376 70.61539337 4.34116E-17 4.99234E-15 4.270106882 6.068693385 26.86025337 2.18711E-07 6.10169E-06 -1.324472065 1.775307591 9.747254895 0.001795907 0.016468725 2.881212684 4.416240051 14.06270571 0.000176815 0.002310043 -1.710080139 3.254580318 19.98426522 7.80821E-06 0.000149948 4.325639777 7.418103025 119.022383 1.03554E-27 3.15124E-25 9.019918703 7.326068378 219.2909789 1.29134E-49 1.11055E-46 1.929931424 0.112528134 10.89047112 0.000966602 0.009870558 5.160598205 -2.52611977 13.61142118 0.000224814 0.002848696 2.366087644 -1.765486911 9.713551769 0.001829142 0.016742444 -6.912025563 -1.300256393 31.88140289 1.63879E-08 5.63743E-07 3.224670168 9.188019024 8.275932676 0.004017402 0.031533418 -0.87841462 6.882473566 13.87398255 0.000195486 0.002520673 -1.351746789 1.570251933 7.559290404 0.005970149 0.042863723 -2.235253452 0.454250045 9.694241479 0.001848464 0.016864673 6.126708909 -2.506537628 20.03056111 7.62143E-06 0.000146932 4.048208928 -0.283855923 39.41185827 3.43206E-10 1.58984E-08 -9.493592682 0.834667262 95.61015473 1.39887E-22 3.04062E-20 3.303232359 -2.052366114 10.70023344 0.00107122 0.010738858 1.418703409 -1.180066144 7.544129338 0.006020591 0.043126329 2.623096931 -2.339156405 7.608065115 0.00581078 0.041936466 3.706995231 -0.494654233 12.43444276 0.000421488 0.004858411 11.50427394 7.941379085 70.63805929 4.29157E-17 4.96417E-15 3.594108604 0.612651676 23.54715197 1.2189E-06 2.89781E-05 -2.695821146 -0.297852174 12.72471738 0.000360854 0.004263859 -1.998206561 1.217227916 15.36354034 8.86831E-05 0.001275747

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1.61578459 -0.744130124 10.66881472 0.001089569 0.010879191 -1.552056447 0.430908535 12.37002832 0.000436281 0.005002689 6.103054604 -2.344319119 22.60913326 1.98539E-06 4.51151E-05 3.533676699 -0.546608772 21.07806325 4.40947E-06 8.98243E-05 2.844712324 -0.899767971 11.81353813 0.000588016 0.006461641 2.092221087 -1.004133934 12.46588298 0.000414453 0.004791275 -1.638730829 -0.255121236 9.281125361 0.002315271 0.020287867 5.654281084 -0.395295895 64.85638111 8.05608E-16 7.96746E-14 -3.361109843 0.394616386 46.25767357 1.0368E-11 6.08541E-10 3.06810694 -2.37662408 7.759837206 0.005342078 0.039295758 -1.500037961 0.726907596 9.964382023 0.001595977 0.014904831 -2.666696996 -2.201715077 9.812136456 0.00173364 0.015986666 2.765118354 -1.899868918 11.49532655 0.000697714 0.007512674 4.958620032 -0.360506355 62.32078092 2.91829E-15 2.64788E-13 -3.313834038 -1.170118237 22.98466681 1.63299E-06 3.80006E-05 -4.461113428 -1.444831232 21.93502834 2.82039E-06 6.07043E-05 4.27657681 -0.98836575 35.28228792 2.85214E-09 1.1397E-07 2.598347539 -0.872348149 8.459040231 0.003632335 0.029182608 1.81021994 -1.100366243 7.799656342 0.005225617 0.038611396 2.796292885 -1.82495257 7.767184902 0.00532039 0.039165358 2.278396304 -1.585009072 12.7972763 0.000347124 0.004128755 -1.690825154 -0.045145117 9.050834974 0.002625749 0.022454522 2.348869023 -1.601957263 10.33584004 0.001304717 0.012650641 2.46355411 -1.902712484 9.523899645 0.002028132 0.018234746 -7.392988897 -1.011156734 47.22800493 6.31911E-12 3.85778E-10 -1.975312675 -0.775043593 8.189593449 0.004213136 0.032723076 -3.436325379 -1.379842896 14.4613126 0.000143068 0.001914672 -1.566203556 0.90778089 7.686133548 0.005564672 0.040500867 -3.734296316 -1.585255841 21.10615231 4.34531E-06 8.86084E-05 -3.479968051 -0.480223745 26.46727448 2.68041E-07 7.34328E-06 4.761009256 2.745005129 90.08827122 2.27768E-21 4.13326E-19 2.571595878 -1.812475052 14.41515842 0.000146617 0.001955557 1.318841588 3.488741183 8.536193104 0.00348153 0.02816551 4.057614281 0.74729795 64.785659 8.35047E-16 8.21753E-14 1.443003283 2.687177209 11.97826081 0.000538248 0.005994676 -1.522302381 -0.478945841 8.394251068 0.003764096 0.029997507 -2.151599901 0.640523617 21.84675553 2.95316E-06 6.31709E-05 1.102841398 0.133060832 7.472046483 0.006266428 0.044506264 1.769784057 -0.510624686 11.2882668 0.000779985 0.008237104 4.183224561 -2.25599932 16.74733876 4.27021E-05 0.0006741 4.552306475 -0.289187854 45.9383143 1.22036E-11 7.03751E-10 4.634275543 2.144193971 30.88322976 2.7403E-08 9.04892E-07 4.82862952 -0.390676479 48.45542716 3.37882E-12 2.13524E-10 -5.585293507 0.741282048 85.69457571 2.09988E-20 3.4613E-18 -3.259682835 -1.926091252 8.069944364 0.00450055 0.034293917 3.558477845 -1.698012601 23.08826216 1.54732E-06 3.62631E-05 5.978071686 -2.498116972 24.57873116 7.13347E-07 1.79061E-05 -3.865495316 3.052966099 93.03432702 5.13952E-22 1.04804E-19 1.247381352 1.690116852 8.935410758 0.002796946 0.023642558 2.898876936 -0.881201148 21.90010365 2.87218E-06 6.16849E-05 -2.55983444 -1.070988174 15.21842859 9.57643E-05 0.00136668

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

3.092167492 -1.253738434 19.13620089 1.21714E-05 0.0002223 3.96457282 0.628313999 64.36377907 1.03442E-15 9.93248E-14 3.04507268 1.256634679 18.67195596 1.55249E-05 0.000277313 7.601629835 -1.009367534 57.8809379 2.78473E-14 2.25745E-12 3.168249163 -1.957644907 11.19460849 0.000820353 0.008603707 4.724609433 0.722691906 43.58635319 4.05658E-11 2.16278E-09 5.540380673 -0.532064803 36.07298504 1.90064E-09 7.75146E-08 2.037774173 0.331194898 19.93524549 8.01098E-06 0.000153099 3.363076461 -1.001881867 15.82013012 6.96575E-05 0.001033627 1.717074748 -1.212604844 10.64604697 0.001103064 0.010986208 -3.405784765 -2.232738405 10.05920104 0.00151589 0.0142308 6.636260152 0.453936538 84.43835963 3.96382E-20 6.42659E-18 3.040407967 -1.60988937 14.98131779 0.000108581 0.001521055 3.79640563 -1.291152431 18.66529889 1.55792E-05 0.000277869 3.946454688 -0.736840041 38.71034288 4.91597E-10 2.23535E-08 -3.163127554 -1.47113156 9.275833209 0.00232197 0.020331374 4.609679875 -0.442757699 26.9036683 2.13853E-07 6.00853E-06 3.304896115 -2.017768625 18.18109489 2.00863E-05 0.000348515 1.83802652 -0.073116023 15.34363848 8.96222E-05 0.001286449 -1.668536901 1.875596611 17.94853677 2.26959E-05 0.000386671 1.91931558 1.25966501 19.41502908 1.05176E-05 0.000195341 3.179169792 -2.088461908 9.347346372 0.002233086 0.019710145 2.891278576 -1.632419172 16.57983429 4.66444E-05 0.000727623 7.825132293 -0.400266313 53.25534843 2.92889E-13 2.06905E-11 1.995322847 -0.748857085 9.125987474 0.002520038 0.021729013 2.66526066 -1.795152704 8.64799191 0.00327422 0.026873061 -2.620774535 -2.260019452 9.464804249 0.002094518 0.018734088 2.690852727 -1.214744966 12.28151356 0.000457467 0.005203394 6.472998468 0.760412302 106.791579 4.94537E-25 1.2601E-22 5.897292837 0.230694121 53.39763264 2.72425E-13 1.93833E-11 2.347739761 1.429975972 13.45427536 0.000244448 0.003060248 3.141315095 -2.147447614 13.18512561 0.00028218 0.00345391 3.428844125 -2.078745929 10.77555456 0.001028494 0.010395304 -3.103138708 -1.799632199 8.439230258 0.003672116 0.029436771 6.037138896 -2.440311819 27.31587755 1.72787E-07 4.95322E-06 6.284977049 -2.024679974 30.72958062 2.96609E-08 9.72955E-07 2.826955317 -1.485572439 19.60700427 9.51198E-06 0.000178677 2.026931633 -1.238269897 10.13337635 0.001456084 0.013767376 6.155544041 -2.238761782 28.37495364 9.99501E-08 2.96819E-06 1.76655107 0.900293038 12.60735336 0.000384232 0.004494448 2.564151119 -1.072215601 19.70201421 9.05059E-06 0.000171148 -1.993989011 3.664498001 44.32806005 2.77707E-11 1.51742E-09 6.646872234 -1.872796368 37.07164913 1.13867E-09 4.86457E-08 1.744176777 -1.823127809 7.434956553 0.006396891 0.045270304 1.844949939 -1.30148598 11.08985206 0.000868014 0.009026981 2.395635305 1.552132211 31.40091012 2.09882E-08 7.07236E-07 2.574547007 -2.137817715 8.688503764 0.003202234 0.026336876 3.224899543 0.024033467 24.7765898 6.43746E-07 1.63457E-05 4.554622987 -1.164844231 24.78552525 6.40768E-07 1.6291E-05 2.679778268 -0.852173677 20.85160545 4.96276E-06 9.93557E-05 3.309613978 -1.744406739 17.38696288 3.0491E-05 0.000499679

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

5.066230399 -1.532562982 26.38487043 2.79723E-07 7.6211E-06 8.588245815 0.000504462 91.45967204 1.1389E-21 2.14547E-19 -8.787230833 3.453998366 133.7199282 6.29128E-31 2.44003E-28 -1.704778784 -0.612152348 8.682894752 0.003212104 0.026407072 6.804560913 0.258478694 93.31842478 4.45228E-22 9.17355E-20 6.085543623 -2.393301808 24.07035176 9.28794E-07 2.26809E-05 -1.569278409 0.142392543 10.84864637 0.00098868 0.010049379 1.773552032 0.159889791 9.073909264 0.002592822 0.022211354 -1.335114342 0.245345733 9.925206914 0.001630305 0.015168126 6.371521812 -1.801694286 32.08388274 1.47657E-08 5.15158E-07 5.207944912 0.493855294 79.70764973 4.34117E-19 6.13345E-17 -1.591748687 1.532628671 10.43867637 0.001234037 0.012053949 2.256287698 -0.30486312 10.7216144 0.001058912 0.010642931 2.593247537 -0.544291343 12.22639085 0.000471183 0.005325709 2.919438403 0.489318858 42.27544557 7.92817E-11 4.04173E-09

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

Gene.stable.ID.version Gene.stable.ID Gene.name 1 ENSMUSG00000000078.7 ENSMUSG00000000078 Klf6 2 ENSMUSG00000000157.16 ENSMUSG00000000157 Itgb2l 3 ENSMUSG00000000204.16 ENSMUSG00000000204 Slfn4 4 ENSMUSG00000000282.12 ENSMUSG00000000282 Mnt 5 ENSMUSG00000000290.13 ENSMUSG00000000290 Itgb2 6 ENSMUSG00000000402.2 ENSMUSG00000000402 Egfl6 7 ENSMUSG00000000411.7 ENSMUSG00000000411 Tssk3 8 ENSMUSG00000000531.5 ENSMUSG00000000531 Grasp 9 ENSMUSG00000000627.15 ENSMUSG00000000627 Sema4f 10 ENSMUSG00000000682.7 ENSMUSG00000000682 Cd52 11 ENSMUSG00000000690.5 ENSMUSG00000000690 Hoxb6 12 ENSMUSG00000000903.3 ENSMUSG00000000903 Vpreb3 13 ENSMUSG00000000982.5 ENSMUSG00000000982 Ccl3 14 ENSMUSG00000001025.8 ENSMUSG00000001025 S100a6 15 ENSMUSG00000001027.7 ENSMUSG00000001027 Scn4a 16 ENSMUSG00000001156.9 ENSMUSG00000001156 Mxd1 17 ENSMUSG00000001300.16 ENSMUSG00000001300 Efnb2 18 ENSMUSG00000001435.15 ENSMUSG00000001435 Col18a1 19 ENSMUSG00000001444.2 ENSMUSG00000001444 Tbx21 20 ENSMUSG00000001506.10 ENSMUSG00000001506 Col1a1 21 ENSMUSG00000001507.16 ENSMUSG00000001507 Itga3 22 ENSMUSG00000001627.12 ENSMUSG00000001627 Ifrd1 23 ENSMUSG00000001946.14 ENSMUSG00000001946 Esam 24 ENSMUSG00000002007.5 ENSMUSG00000002007 Srpk3 25 ENSMUSG00000002033.14 ENSMUSG00000002033 Cd3g 26 ENSMUSG00000002083.13 ENSMUSG00000002083 Bbc3 27 ENSMUSG00000002500.15 ENSMUSG00000002500 Rpl3l 28 ENSMUSG00000002799.6 ENSMUSG00000002799 Jag2 29 ENSMUSG00000002983.17 ENSMUSG00000002983 Relb 30 ENSMUSG00000003032.8 ENSMUSG00000003032 31 ENSMUSG00000003283.14 ENSMUSG00000003283 Hck 32 ENSMUSG00000003379.7 ENSMUSG00000003379 Cd79a 33 ENSMUSG00000003484.4 ENSMUSG00000003484 Cyp4f18 34 ENSMUSG00000003882.5 ENSMUSG00000003882 Il7r 35 ENSMUSG00000004609.11 ENSMUSG00000004609 Cd33 36 ENSMUSG00000004668.14 ENSMUSG00000004668 Abca13 37 ENSMUSG00000004730.15 ENSMUSG00000004730 Adgre1 38 ENSMUSG00000004864.13 ENSMUSG00000004864 Mapk13 39 ENSMUSG00000005364.11 ENSMUSG00000005364 Il5ra 40 ENSMUSG00000005413.8 ENSMUSG00000005413 Hmox1 41 ENSMUSG00000005540.10 ENSMUSG00000005540 Fcer2a 42 ENSMUSG00000005800.3 ENSMUSG00000005800 Mmp8 43 ENSMUSG00000005883.15 ENSMUSG00000005883 Spo11 44 ENSMUSG00000006154.13 ENSMUSG00000006154 Eps8l1 45 ENSMUSG00000006386.15 ENSMUSG00000006386 Tek 46 ENSMUSG00000006462.6 ENSMUSG00000006462 A530013C23Rik 47 ENSMUSG00000006574.15 ENSMUSG00000006574 Slc4a1 48 ENSMUSG00000007872.3 ENSMUSG00000007872 Id3

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

49 ENSMUSG00000008193.13 ENSMUSG00000008193 Spib 50 ENSMUSG00000009292.18 ENSMUSG00000009292 Trpm2 51 ENSMUSG00000009628.14 ENSMUSG00000009628 Tex15 52 ENSMUSG00000009633.3 ENSMUSG00000009633 G0s2 53 ENSMUSG00000011256.16 ENSMUSG00000011256 Adam19 54 ENSMUSG00000012428.9 ENSMUSG00000012428 Steap4 55 ENSMUSG00000013076.17 ENSMUSG00000013076 Amotl1 56 ENSMUSG00000013974.3 ENSMUSG00000013974 Mcemp1 57 ENSMUSG00000014030.15 ENSMUSG00000014030 Pax5 58 ENSMUSG00000014453.4 ENSMUSG00000014453 Blk 59 ENSMUSG00000014543.14 ENSMUSG00000014543 Klra17 60 ENSMUSG00000015053.14 ENSMUSG00000015053 Gata2 61 ENSMUSG00000015094.16 ENSMUSG00000015094 Npdc1 62 ENSMUSG00000015143.15 ENSMUSG00000015143 Actn1 63 ENSMUSG00000015314.10 ENSMUSG00000015314 Slamf6 64 ENSMUSG00000015316.11 ENSMUSG00000015316 Slamf1 65 ENSMUSG00000015340.10 ENSMUSG00000015340 Cybb 66 ENSMUSG00000015396.4 ENSMUSG00000015396 Cd83 67 ENSMUSG00000015950.13 ENSMUSG00000015950 Ncf1 68 ENSMUSG00000016529.5 ENSMUSG00000016529 Il10 69 ENSMUSG00000016756.17 ENSMUSG00000016756 Cmah 70 ENSMUSG00000017009.3 ENSMUSG00000017009 Sdc4 71 ENSMUSG00000017057.9 ENSMUSG00000017057 Il13ra1 72 ENSMUSG00000017144.8 ENSMUSG00000017144 Rnd3 73 ENSMUSG00000017400.10 ENSMUSG00000017400 Stac2 74 ENSMUSG00000017418.13 ENSMUSG00000017418 Arl5b 75 ENSMUSG00000017652.16 ENSMUSG00000017652 Cd40 76 ENSMUSG00000017737.2 ENSMUSG00000017737 Mmp9 77 ENSMUSG00000017754.13 ENSMUSG00000017754 Pltp 78 ENSMUSG00000018168.8 ENSMUSG00000018168 Ikzf3 79 ENSMUSG00000018476.7 ENSMUSG00000018476 Kdm6b 80 ENSMUSG00000018593.13 ENSMUSG00000018593 Sparc 81 ENSMUSG00000018698.15 ENSMUSG00000018698 Lhx1 82 ENSMUSG00000018819.10 ENSMUSG00000018819 Lsp1 83 ENSMUSG00000018924.6 ENSMUSG00000018924 Alox15 84 ENSMUSG00000018927.3 ENSMUSG00000018927 Ccl6 85 ENSMUSG00000018930.3 ENSMUSG00000018930 Ccl4 86 ENSMUSG00000019124.10 ENSMUSG00000019124 Scrn1 87 ENSMUSG00000019312.10 ENSMUSG00000019312 Grb7 88 ENSMUSG00000019850.11 ENSMUSG00000019850 Tnfaip3 89 ENSMUSG00000019866.14 ENSMUSG00000019866 Crybg1 90 ENSMUSG00000019894.14 ENSMUSG00000019894 Slc6a15 91 ENSMUSG00000019935.16 ENSMUSG00000019935 Slc17a8 92 ENSMUSG00000019960.8 ENSMUSG00000019960 Dusp6 93 ENSMUSG00000019970.15 ENSMUSG00000019970 Sgk1 94 ENSMUSG00000019987.9 ENSMUSG00000019987 Arg1 95 ENSMUSG00000020010.7 ENSMUSG00000020010 Vnn3 96 ENSMUSG00000020053.18 ENSMUSG00000020053 Igf1 97 ENSMUSG00000020101.14 ENSMUSG00000020101 Vsir 98 ENSMUSG00000020183.11 ENSMUSG00000020183 Cpm

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

99 ENSMUSG00000020205.8 ENSMUSG00000020205 Phlda1 100 ENSMUSG00000020275.9 ENSMUSG00000020275 Rel 101 ENSMUSG00000020300.14 ENSMUSG00000020300 Cpeb4 102 ENSMUSG00000020395.13 ENSMUSG00000020395 Itk 103 ENSMUSG00000020396.8 ENSMUSG00000020396 Nefh 104 ENSMUSG00000020401.6 ENSMUSG00000020401 Fam71b 105 ENSMUSG00000020423.6 ENSMUSG00000020423 Btg2 106 ENSMUSG00000020609.14 ENSMUSG00000020609 Apob 107 ENSMUSG00000020653.12 ENSMUSG00000020653 Klf11 108 ENSMUSG00000020681.14 ENSMUSG00000020681 Ace 109 ENSMUSG00000020701.12 ENSMUSG00000020701 Tmem132e 110 ENSMUSG00000020774.9 ENSMUSG00000020774 Aspa 111 ENSMUSG00000020846.6 ENSMUSG00000020846 Rflnb 112 ENSMUSG00000020893.17 ENSMUSG00000020893 Per1 113 ENSMUSG00000020963.15 ENSMUSG00000020963 Tshr 114 ENSMUSG00000021025.8 ENSMUSG00000021025 Nfkbia 115 ENSMUSG00000021125.6 ENSMUSG00000021125 Arg2 116 ENSMUSG00000021298.8 ENSMUSG00000021298 Gpr132 117 ENSMUSG00000021356.10 ENSMUSG00000021356 Irf4 118 ENSMUSG00000021365.15 ENSMUSG00000021365 Nedd9 119 ENSMUSG00000021411.16 ENSMUSG00000021411 Pxdc1 120 ENSMUSG00000021701.8 ENSMUSG00000021701 Plk2 121 ENSMUSG00000021892.14 ENSMUSG00000021892 Sh3bp5 122 ENSMUSG00000021986.8 ENSMUSG00000021986 Amer2 123 ENSMUSG00000022010.19 ENSMUSG00000022010 Tsc22d1 124 ENSMUSG00000022015.8 ENSMUSG00000022015 Tnfsf11 125 ENSMUSG00000022026.7 ENSMUSG00000022026 Olfm4 126 ENSMUSG00000022041.10 ENSMUSG00000022041 Chrna2 127 ENSMUSG00000022103.10 ENSMUSG00000022103 Gfra2 128 ENSMUSG00000022126.6 ENSMUSG00000022126 Acod1 129 ENSMUSG00000022220.14 ENSMUSG00000022220 Adcy4 130 ENSMUSG00000022303.9 ENSMUSG00000022303 Dcstamp 131 ENSMUSG00000022346.15 ENSMUSG00000022346 Myc 132 ENSMUSG00000022367.7 ENSMUSG00000022367 Has2 133 ENSMUSG00000022416.15 ENSMUSG00000022416 Cacna1i 134 ENSMUSG00000022483.17 ENSMUSG00000022483 Col2a1 135 ENSMUSG00000022500.15 ENSMUSG00000022500 Litaf 136 ENSMUSG00000022508.5 ENSMUSG00000022508 Bcl6 137 ENSMUSG00000022512.3 ENSMUSG00000022512 Cldn1 138 ENSMUSG00000022521.10 ENSMUSG00000022521 Crebbp 139 ENSMUSG00000022555.12 ENSMUSG00000022555 Dgat1 140 ENSMUSG00000022582.4 ENSMUSG00000022582 Ly6g 141 ENSMUSG00000022651.6 ENSMUSG00000022651 Retnlg 142 ENSMUSG00000022686.14 ENSMUSG00000022686 B3gnt5 143 ENSMUSG00000022696.17 ENSMUSG00000022696 Sidt1 144 ENSMUSG00000022824.12 ENSMUSG00000022824 Muc13 145 ENSMUSG00000022893.14 ENSMUSG00000022893 Adamts1 146 ENSMUSG00000022895.16 ENSMUSG00000022895 Ets2 147 ENSMUSG00000022900.14 ENSMUSG00000022900 Ildr1 148 ENSMUSG00000022996.15 ENSMUSG00000022996 Wnt10b

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

149 ENSMUSG00000023034.7 ENSMUSG00000023034 Nr4a1 150 ENSMUSG00000023067.14 ENSMUSG00000023067 Cdkn1a 151 ENSMUSG00000023132.8 ENSMUSG00000023132 Gzma 152 ENSMUSG00000023274.14 ENSMUSG00000023274 Cd4 153 ENSMUSG00000023903.8 ENSMUSG00000023903 Mmp25 154 ENSMUSG00000023913.17 ENSMUSG00000023913 Pla2g7 155 ENSMUSG00000023947.8 ENSMUSG00000023947 Nfkbie 156 ENSMUSG00000023951.17 ENSMUSG00000023951 Vegfa 157 ENSMUSG00000024042.6 ENSMUSG00000024042 Sik1 158 ENSMUSG00000024066.9 ENSMUSG00000024066 Xdh 159 ENSMUSG00000024084.8 ENSMUSG00000024084 Qpct 160 ENSMUSG00000024164.15 ENSMUSG00000024164 C3 161 ENSMUSG00000024353.4 ENSMUSG00000024353 Mzb1 162 ENSMUSG00000024401.14 ENSMUSG00000024401 Tnf 163 ENSMUSG00000024521.7 ENSMUSG00000024521 Pmaip1 164 ENSMUSG00000024610.14 ENSMUSG00000024610 Cd74 165 ENSMUSG00000024659.14 ENSMUSG00000024659 Anxa1 166 ENSMUSG00000024669.7 ENSMUSG00000024669 Cd5 167 ENSMUSG00000024673.9 ENSMUSG00000024673 Ms4a1 168 ENSMUSG00000024730.7 ENSMUSG00000024730 Ms4a8a 169 ENSMUSG00000024737.2 ENSMUSG00000024737 Slc15a3 170 ENSMUSG00000024774.15 ENSMUSG00000024774 Ankrd22 171 ENSMUSG00000024885.8 ENSMUSG00000024885 Aldh3b1 172 ENSMUSG00000024936.7 ENSMUSG00000024936 Kcnk7 173 ENSMUSG00000025044.16 ENSMUSG00000025044 Msr1 174 ENSMUSG00000025089.15 ENSMUSG00000025089 Gfra1 175 ENSMUSG00000025094.7 ENSMUSG00000025094 Slc18a2 176 ENSMUSG00000025161.16 ENSMUSG00000025161 Slc16a3 177 ENSMUSG00000025225.14 ENSMUSG00000025225 Nfkb2 178 ENSMUSG00000025270.13 ENSMUSG00000025270 Alas2 179 ENSMUSG00000025318.13 ENSMUSG00000025318 Jph3 180 ENSMUSG00000025330.6 ENSMUSG00000025330 Padi4 181 ENSMUSG00000025473.16 ENSMUSG00000025473 Adam8 182 ENSMUSG00000025555.14 ENSMUSG00000025555 Farp1 183 ENSMUSG00000025608.9 ENSMUSG00000025608 Podxl 184 ENSMUSG00000025648.18 ENSMUSG00000025648 Pfkfb4 185 ENSMUSG00000025701.12 ENSMUSG00000025701 Alox5 186 ENSMUSG00000025804.5 ENSMUSG00000025804 Ccr1 187 ENSMUSG00000025880.11 ENSMUSG00000025880 Smad7 188 ENSMUSG00000025887.10 ENSMUSG00000025887 Casp12 189 ENSMUSG00000025916.10 ENSMUSG00000025916 Ppp1r42 190 ENSMUSG00000026011.13 ENSMUSG00000026011 Ctla4 191 ENSMUSG00000026012.2 ENSMUSG00000026012 Cd28 192 ENSMUSG00000026042.16 ENSMUSG00000026042 Col5a2 193 ENSMUSG00000026070.15 ENSMUSG00000026070 Il18r1 194 ENSMUSG00000026073.13 ENSMUSG00000026073 Il1r2 195 ENSMUSG00000026094.14 ENSMUSG00000026094 Stk17b 196 ENSMUSG00000026117.10 ENSMUSG00000026117 Zap70 197 ENSMUSG00000026177.11 ENSMUSG00000026177 Slc11a1 198 ENSMUSG00000026180.8 ENSMUSG00000026180 Cxcr2

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

199 ENSMUSG00000026193.15 ENSMUSG00000026193 Fn1 200 ENSMUSG00000026220.6 ENSMUSG00000026220 Slc16a14 201 ENSMUSG00000026360.9 ENSMUSG00000026360 Rgs2 202 ENSMUSG00000026365.15 ENSMUSG00000026365 Cfh 203 ENSMUSG00000026450.14 ENSMUSG00000026450 Chit1 204 ENSMUSG00000026480.12 ENSMUSG00000026480 Ncf2 205 ENSMUSG00000026576.12 ENSMUSG00000026576 Atp1b1 206 ENSMUSG00000026616.15 ENSMUSG00000026616 Cr2 207 ENSMUSG00000026628.13 ENSMUSG00000026628 Atf3 208 ENSMUSG00000026712.3 ENSMUSG00000026712 Mrc1 209 ENSMUSG00000026770.5 ENSMUSG00000026770 Il2ra 210 ENSMUSG00000026822.14 ENSMUSG00000026822 Lcn2 211 ENSMUSG00000026826.13 ENSMUSG00000026826 Nr4a2 212 ENSMUSG00000026832.12 ENSMUSG00000026832 Cytip 213 ENSMUSG00000026835.15 ENSMUSG00000026835 Fcnb 214 ENSMUSG00000026879.14 ENSMUSG00000026879 Gsn 215 ENSMUSG00000026893.4 ENSMUSG00000026893 Gca 216 ENSMUSG00000026923.15 ENSMUSG00000026923 Notch1 217 ENSMUSG00000026938.10 ENSMUSG00000026938 Fcna 218 ENSMUSG00000026981.15 ENSMUSG00000026981 Il1rn 219 ENSMUSG00000027068.6 ENSMUSG00000027068 Dhrs9 220 ENSMUSG00000027297.14 ENSMUSG00000027297 Ltk 221 ENSMUSG00000027313.3 ENSMUSG00000027313 Chac1 222 ENSMUSG00000027322.11 ENSMUSG00000027322 Siglec1 223 ENSMUSG00000027347.18 ENSMUSG00000027347 Rasgrp1 224 ENSMUSG00000027358.6 ENSMUSG00000027358 Bmp2 225 ENSMUSG00000027381.16 ENSMUSG00000027381 Bcl2l11 226 ENSMUSG00000027398.13 ENSMUSG00000027398 Il1b 227 ENSMUSG00000027401.9 ENSMUSG00000027401 Tgm3 228 ENSMUSG00000027505.2 ENSMUSG00000027505 Fam209 229 ENSMUSG00000027660.16 ENSMUSG00000027660 Skil 230 ENSMUSG00000027737.10 ENSMUSG00000027737 Slc7a11 231 ENSMUSG00000027803.14 ENSMUSG00000027803 Wwtr1 232 ENSMUSG00000027857.10 ENSMUSG00000027857 Tshb 233 ENSMUSG00000027863.8 ENSMUSG00000027863 Cd2 234 ENSMUSG00000027907.4 ENSMUSG00000027907 S100a11 235 ENSMUSG00000027962.14 ENSMUSG00000027962 Vcam1 236 ENSMUSG00000027966.20 ENSMUSG00000027966 Col11a1 237 ENSMUSG00000027985.14 ENSMUSG00000027985 Lef1 238 ENSMUSG00000027995.10 ENSMUSG00000027995 Tlr2 239 ENSMUSG00000028012.15 ENSMUSG00000028012 Rrh 240 ENSMUSG00000028024.14 ENSMUSG00000028024 Enpep 241 ENSMUSG00000028071.12 ENSMUSG00000028071 Sh2d2a 242 ENSMUSG00000028111.4 ENSMUSG00000028111 Ctsk 243 ENSMUSG00000028121.8 ENSMUSG00000028121 Bcar3 244 ENSMUSG00000028128.13 ENSMUSG00000028128 F3 245 ENSMUSG00000028191.11 ENSMUSG00000028191 Bcl10 246 ENSMUSG00000028211.11 ENSMUSG00000028211 Trp53inp1 247 ENSMUSG00000028214.13 ENSMUSG00000028214 Gem 248 ENSMUSG00000028238.6 ENSMUSG00000028238 Atp6v0d2

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

249 ENSMUSG00000028341.9 ENSMUSG00000028341 Nr4a3 250 ENSMUSG00000028459.11 ENSMUSG00000028459 Cd72 251 ENSMUSG00000028460.6 ENSMUSG00000028460 Sit1 252 ENSMUSG00000028525.16 ENSMUSG00000028525 Pde4b 253 ENSMUSG00000028680.14 ENSMUSG00000028680 Plk3 254 ENSMUSG00000028681.11 ENSMUSG00000028681 Ptch2 255 ENSMUSG00000028793.15 ENSMUSG00000028793 Rnf19b 256 ENSMUSG00000028874.14 ENSMUSG00000028874 Fgr 257 ENSMUSG00000029082.17 ENSMUSG00000029082 Bst1 258 ENSMUSG00000029084.5 ENSMUSG00000029084 Cd38 259 ENSMUSG00000029093.14 ENSMUSG00000029093 Sorcs2 260 ENSMUSG00000029122.11 ENSMUSG00000029122 Evc 261 ENSMUSG00000029135.10 ENSMUSG00000029135 Fosl2 262 ENSMUSG00000029314.14 ENSMUSG00000029314 Gpat3 263 ENSMUSG00000029378.5 ENSMUSG00000029378 Areg 264 ENSMUSG00000029380.11 ENSMUSG00000029380 Cxcl1 265 ENSMUSG00000029385.14 ENSMUSG00000029385 Ccng2 266 ENSMUSG00000029403.14 ENSMUSG00000029403 Cdkl2 267 ENSMUSG00000029530.16 ENSMUSG00000029530 Ccr9 268 ENSMUSG00000029603.15 ENSMUSG00000029603 Dtx1 269 ENSMUSG00000030048.5 ENSMUSG00000030048 Gkn3 270 ENSMUSG00000030069.15 ENSMUSG00000030069 Prok2 271 ENSMUSG00000030103.11 ENSMUSG00000030103 Bhlhe40 272 ENSMUSG00000030109.15 ENSMUSG00000030109 Slc6a12 273 ENSMUSG00000030142.10 ENSMUSG00000030142 Clec4e 274 ENSMUSG00000030144.4 ENSMUSG00000030144 Clec4d 275 ENSMUSG00000030148.15 ENSMUSG00000030148 Clec4a2 276 ENSMUSG00000030156.5 ENSMUSG00000030156 Cd69 277 ENSMUSG00000030162.14 ENSMUSG00000030162 Olr1 278 ENSMUSG00000030167.15 ENSMUSG00000030167 Klrc1 279 ENSMUSG00000030178.15 ENSMUSG00000030178 Klra13-ps 280 ENSMUSG00000030187.15 ENSMUSG00000030187 Klra2 281 ENSMUSG00000030208.15 ENSMUSG00000030208 Emp1 282 ENSMUSG00000030214.7 ENSMUSG00000030214 Plbd1 283 ENSMUSG00000030283.7 ENSMUSG00000030283 St8sia1 284 ENSMUSG00000030401.16 ENSMUSG00000030401 Rtn2 285 ENSMUSG00000030413.7 ENSMUSG00000030413 Pglyrp1 286 ENSMUSG00000030427.17 ENSMUSG00000030427 Lilra6 287 ENSMUSG00000030468.12 ENSMUSG00000030468 Siglecg 288 ENSMUSG00000030474.9 ENSMUSG00000030474 Siglece 289 ENSMUSG00000030507.6 ENSMUSG00000030507 Dbx1 290 ENSMUSG00000030559.8 ENSMUSG00000030559 Rab38 291 ENSMUSG00000030577.14 ENSMUSG00000030577 Cd22 292 ENSMUSG00000030589.15 ENSMUSG00000030589 Rasgrp4 293 ENSMUSG00000030724.7 ENSMUSG00000030724 Cd19 294 ENSMUSG00000030757.13 ENSMUSG00000030757 Zkscan2 295 ENSMUSG00000030786.18 ENSMUSG00000030786 Itgam 296 ENSMUSG00000030787.4 ENSMUSG00000030787 Lyve1 297 ENSMUSG00000031298.15 ENSMUSG00000031298 Adgrg2 298 ENSMUSG00000031375.17 ENSMUSG00000031375 Bgn

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

299 ENSMUSG00000031391.18 ENSMUSG00000031391 L1cam 300 ENSMUSG00000031494.7 ENSMUSG00000031494 Cd209a 301 ENSMUSG00000031495.8 ENSMUSG00000031495 Cd209d 302 ENSMUSG00000031497.9 ENSMUSG00000031497 Tnfsf13b 303 ENSMUSG00000031610.3 ENSMUSG00000031610 Scrg1 304 ENSMUSG00000031766.4 ENSMUSG00000031766 Slc12a3 305 ENSMUSG00000031799.9 ENSMUSG00000031799 Tpm4 306 ENSMUSG00000031824.15 ENSMUSG00000031824 6430548M08Rik 307 ENSMUSG00000031825.16 ENSMUSG00000031825 Crispld2 308 ENSMUSG00000031871.9 ENSMUSG00000031871 Cdh5 309 ENSMUSG00000031880.7 ENSMUSG00000031880 Rrad 310 ENSMUSG00000032000.17 ENSMUSG00000032000 Birc3 311 ENSMUSG00000032023.7 ENSMUSG00000032023 Jhy 312 ENSMUSG00000032035.15 ENSMUSG00000032035 Ets1 313 ENSMUSG00000032053.8 ENSMUSG00000032053 Pou2af1 314 ENSMUSG00000032093.7 ENSMUSG00000032093 Cd3e 315 ENSMUSG00000032094.8 ENSMUSG00000032094 Cd3d 316 ENSMUSG00000032122.15 ENSMUSG00000032122 Slc37a2 317 ENSMUSG00000032135.15 ENSMUSG00000032135 Mcam 318 ENSMUSG00000032193.9 ENSMUSG00000032193 Ldlr 319 ENSMUSG00000032372.14 ENSMUSG00000032372 Plscr2 320 ENSMUSG00000032446.14 ENSMUSG00000032446 Eomes 321 ENSMUSG00000032484.8 ENSMUSG00000032484 Ngp 322 ENSMUSG00000032487.8 ENSMUSG00000032487 Ptgs2 323 ENSMUSG00000032496.7 ENSMUSG00000032496 Ltf 324 ENSMUSG00000032501.9 ENSMUSG00000032501 Trib1 325 ENSMUSG00000032515.8 ENSMUSG00000032515 Csrnp1 326 ENSMUSG00000032572.9 ENSMUSG00000032572 Col6a4 327 ENSMUSG00000032691.14 ENSMUSG00000032691 Nlrp3 328 ENSMUSG00000032724.5 ENSMUSG00000032724 Abtb2 329 ENSMUSG00000032739.16 ENSMUSG00000032739 Pram1 330 ENSMUSG00000032776.9 ENSMUSG00000032776 Mctp2 331 ENSMUSG00000032915.6 ENSMUSG00000032915 Adgre4 332 ENSMUSG00000033170.14 ENSMUSG00000033170 Card10 333 ENSMUSG00000033213.16 ENSMUSG00000033213 AA467197 334 ENSMUSG00000033355.6 ENSMUSG00000033355 Rtp4 335 ENSMUSG00000033508.7 ENSMUSG00000033508 Asprv1 336 ENSMUSG00000033730.4 ENSMUSG00000033730 Egr3 337 ENSMUSG00000033777.4 ENSMUSG00000033777 Tlr13 338 ENSMUSG00000033849.3 ENSMUSG00000033849 B3galt2 339 ENSMUSG00000033880.11 ENSMUSG00000033880 Lgals3bp 340 ENSMUSG00000033949.11 ENSMUSG00000033949 Trim36 341 ENSMUSG00000033963.16 ENSMUSG00000033963 Fancd2os 342 ENSMUSG00000034059.13 ENSMUSG00000034059 Ypel4 343 ENSMUSG00000034248.7 ENSMUSG00000034248 Slc25a37 344 ENSMUSG00000034394.14 ENSMUSG00000034394 Lif 345 ENSMUSG00000034488.14 ENSMUSG00000034488 Edil3 346 ENSMUSG00000034570.12 ENSMUSG00000034570 Inpp5j 347 ENSMUSG00000034634.7 ENSMUSG00000034634 Ly6d 348 ENSMUSG00000034640.9 ENSMUSG00000034640 Tiparp

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

349 ENSMUSG00000034641.2 ENSMUSG00000034641 Cd300ld 350 ENSMUSG00000034686.8 ENSMUSG00000034686 Prr7 351 ENSMUSG00000034765.6 ENSMUSG00000034765 Dusp5 352 ENSMUSG00000034855.13 ENSMUSG00000034855 Cxcl10 353 ENSMUSG00000035033.15 ENSMUSG00000035033 Tbr1 354 ENSMUSG00000035042.2 ENSMUSG00000035042 Ccl5 355 ENSMUSG00000035299.16 ENSMUSG00000035299 Mid1 356 ENSMUSG00000035356.17 ENSMUSG00000035356 Nfkbiz 357 ENSMUSG00000035448.9 ENSMUSG00000035448 Ccr3 358 ENSMUSG00000035459.18 ENSMUSG00000035459 Stab2 359 ENSMUSG00000035580.10 ENSMUSG00000035580 Kcnh8 360 ENSMUSG00000035783.8 ENSMUSG00000035783 Acta2 361 ENSMUSG00000035934.16 ENSMUSG00000035934 Pknox2 362 ENSMUSG00000036273.15 ENSMUSG00000036273 Lrrk2 363 ENSMUSG00000036322.10 ENSMUSG00000036322 H2-Ea-ps 364 ENSMUSG00000036356.15 ENSMUSG00000036356 Csgalnact1 365 ENSMUSG00000036362.2 ENSMUSG00000036362 P2ry13 366 ENSMUSG00000036469.16 ENSMUSG00000036469 43525 367 ENSMUSG00000036478.8 ENSMUSG00000036478 Btg1 368 ENSMUSG00000036594.14 ENSMUSG00000036594 H2-Aa 369 ENSMUSG00000036887.5 ENSMUSG00000036887 C1qa 370 ENSMUSG00000036896.5 ENSMUSG00000036896 C1qc 371 ENSMUSG00000036931.15 ENSMUSG00000036931 Nfkbid 372 ENSMUSG00000036957.8 ENSMUSG00000036957 Lrfn3 373 ENSMUSG00000037014.4 ENSMUSG00000037014 Sstr4 374 ENSMUSG00000037095.8 ENSMUSG00000037095 Lrg1 375 ENSMUSG00000037126.16 ENSMUSG00000037126 Psd 376 ENSMUSG00000037169.15 ENSMUSG00000037169 Mycn 377 ENSMUSG00000037202.6 ENSMUSG00000037202 Prf1 378 ENSMUSG00000037211.12 ENSMUSG00000037211 Spry1 379 ENSMUSG00000037263.13 ENSMUSG00000037263 Aldh3b3 380 ENSMUSG00000037321.17 ENSMUSG00000037321 Tap1 381 ENSMUSG00000037366.14 ENSMUSG00000037366 Pafah2 382 ENSMUSG00000037465.10 ENSMUSG00000037465 Klf10 383 ENSMUSG00000037583.2 ENSMUSG00000037583 Nr0b2 384 ENSMUSG00000037868.15 ENSMUSG00000037868 Egr2 385 ENSMUSG00000037887.11 ENSMUSG00000037887 Dusp8 386 ENSMUSG00000037922.13 ENSMUSG00000037922 Bank1 387 ENSMUSG00000037992.16 ENSMUSG00000037992 Rara 388 ENSMUSG00000038059.6 ENSMUSG00000038059 Smim3 389 ENSMUSG00000038132.6 ENSMUSG00000038132 Rbm24 390 ENSMUSG00000038179.13 ENSMUSG00000038179 Slamf7 391 ENSMUSG00000038188.17 ENSMUSG00000038188 Scarf1 392 ENSMUSG00000038352.15 ENSMUSG00000038352 Arl5c 393 ENSMUSG00000038357.10 ENSMUSG00000038357 Camp 394 ENSMUSG00000038375.15 ENSMUSG00000038375 Trp53inp2 395 ENSMUSG00000038421.13 ENSMUSG00000038421 Fcrla 396 ENSMUSG00000038587.9 ENSMUSG00000038587 Akap12 397 ENSMUSG00000038670.11 ENSMUSG00000038670 Mybpc2 398 ENSMUSG00000038807.18 ENSMUSG00000038807 Rap1gap2

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

399 ENSMUSG00000038894.7 ENSMUSG00000038894 Irs2 400 ENSMUSG00000039196.2 ENSMUSG00000039196 Orm1 401 ENSMUSG00000039208.15 ENSMUSG00000039208 Metrnl 402 ENSMUSG00000039264.9 ENSMUSG00000039264 Gimap3 403 ENSMUSG00000039270.9 ENSMUSG00000039270 Megf9 404 ENSMUSG00000039377.7 ENSMUSG00000039377 Hlx 405 ENSMUSG00000039384.8 ENSMUSG00000039384 Dusp10 406 ENSMUSG00000039616.9 ENSMUSG00000039616 Mocos 407 ENSMUSG00000039782.14 ENSMUSG00000039782 Cpeb2 408 ENSMUSG00000039960.5 ENSMUSG00000039960 Rhou 409 ENSMUSG00000040026.8 ENSMUSG00000040026 Saa3 410 ENSMUSG00000040093.15 ENSMUSG00000040093 Bmf 411 ENSMUSG00000040128.9 ENSMUSG00000040128 Pnrc1 412 ENSMUSG00000040152.8 ENSMUSG00000040152 Thbs1 413 ENSMUSG00000040270.16 ENSMUSG00000040270 Bach2 414 ENSMUSG00000040276.15 ENSMUSG00000040276 Pacsin1 415 ENSMUSG00000040405.13 ENSMUSG00000040405 Havcr1 416 ENSMUSG00000040522.5 ENSMUSG00000040522 Tlr8 417 ENSMUSG00000040592.11 ENSMUSG00000040592 Cd79b 418 ENSMUSG00000040624.17 ENSMUSG00000040624 Plekhg1 419 ENSMUSG00000040663.8 ENSMUSG00000040663 Clcf1 420 ENSMUSG00000040693.7 ENSMUSG00000040693 Slco4c1 421 ENSMUSG00000040859.14 ENSMUSG00000040859 Bsdc1 422 ENSMUSG00000041046.7 ENSMUSG00000041046 Ramp3 423 ENSMUSG00000041202.12 ENSMUSG00000041202 Pla2g2d 424 ENSMUSG00000041324.14 ENSMUSG00000041324 Inhba 425 ENSMUSG00000041361.13 ENSMUSG00000041361 Myzap 426 ENSMUSG00000041481.16 ENSMUSG00000041481 Serpina3g 427 ENSMUSG00000041552.7 ENSMUSG00000041552 Ptchd1 428 ENSMUSG00000041827.15 ENSMUSG00000041827 Oasl1 429 ENSMUSG00000041831.16 ENSMUSG00000041831 Sytl3 430 ENSMUSG00000042265.13 ENSMUSG00000042265 Trem1 431 ENSMUSG00000042268.10 ENSMUSG00000042268 Slc26a9 432 ENSMUSG00000042286.13 ENSMUSG00000042286 Stab1 433 ENSMUSG00000042417.5 ENSMUSG00000042417 Ccno 434 ENSMUSG00000042453.14 ENSMUSG00000042453 Reln 435 ENSMUSG00000042474.6 ENSMUSG00000042474 Fcmr 436 ENSMUSG00000042514.11 ENSMUSG00000042514 Klhl14 437 ENSMUSG00000042599.8 ENSMUSG00000042599 Kdm7a 438 ENSMUSG00000042622.14 ENSMUSG00000042622 Maff 439 ENSMUSG00000042677.7 ENSMUSG00000042677 Zc3h12a 440 ENSMUSG00000042724.8 ENSMUSG00000042724 Map3k9 441 ENSMUSG00000042759.12 ENSMUSG00000042759 Apobr 442 ENSMUSG00000042804.13 ENSMUSG00000042804 Gpr153 443 ENSMUSG00000042807.15 ENSMUSG00000042807 Hecw2 444 ENSMUSG00000043099.4 ENSMUSG00000043099 Hic1 445 ENSMUSG00000043168.12 ENSMUSG00000043168 4930426D05Rik 446 ENSMUSG00000043243.15 ENSMUSG00000043243 Fam129c 447 ENSMUSG00000043286.12 ENSMUSG00000043286 Pnpla1 448 ENSMUSG00000043336.14 ENSMUSG00000043336 Filip1l

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

449 ENSMUSG00000043740.15 ENSMUSG00000043740 B430306N03Rik 450 ENSMUSG00000043795.9 ENSMUSG00000043795 Prr33 451 ENSMUSG00000043832.13 ENSMUSG00000043832 Clec4a3 452 ENSMUSG00000043939.15 ENSMUSG00000043939 A530064D06Rik 453 ENSMUSG00000043953.12 ENSMUSG00000043953 Ccrl2 454 ENSMUSG00000044103.4 ENSMUSG00000044103 Il1f9 455 ENSMUSG00000044749.13 ENSMUSG00000044749 Abca6 456 ENSMUSG00000044786.6 ENSMUSG00000044786 Zfp36 457 ENSMUSG00000044814.6 ENSMUSG00000044814 Olfr543 458 ENSMUSG00000045136.6 ENSMUSG00000045136 Tubb2b 459 ENSMUSG00000045377.5 ENSMUSG00000045377 Tmem88 460 ENSMUSG00000045502.6 ENSMUSG00000045502 Hcar2 461 ENSMUSG00000045551.7 ENSMUSG00000045551 Fpr1 462 ENSMUSG00000045658.16 ENSMUSG00000045658 Pid1 463 ENSMUSG00000045672.15 ENSMUSG00000045672 Col27a1 464 ENSMUSG00000045777.14 ENSMUSG00000045777 Ifitm10 465 ENSMUSG00000045903.8 ENSMUSG00000045903 Npas4 466 ENSMUSG00000046006.6 ENSMUSG00000046006 Gapt 467 ENSMUSG00000046223.10 ENSMUSG00000046223 Plaur 468 ENSMUSG00000046245.13 ENSMUSG00000046245 Pilra 469 ENSMUSG00000046748.8 ENSMUSG00000046748 Tmem45a2 470 ENSMUSG00000046768.13 ENSMUSG00000046768 Rhoj 471 ENSMUSG00000046807.10 ENSMUSG00000046807 Lrrc75b 472 ENSMUSG00000046879.7 ENSMUSG00000046879 Irgm1 473 ENSMUSG00000046962.16 ENSMUSG00000046962 Zbtb21 474 ENSMUSG00000047180.8 ENSMUSG00000047180 Neurl3 475 ENSMUSG00000047222.7 ENSMUSG00000047222 Rnase2a 476 ENSMUSG00000047407.17 ENSMUSG00000047407 Tgif1 477 ENSMUSG00000047712.8 ENSMUSG00000047712 Ust 478 ENSMUSG00000047798.15 ENSMUSG00000047798 Cd300lf 479 ENSMUSG00000047867.11 ENSMUSG00000047867 Gimap6 480 ENSMUSG00000047880.15 ENSMUSG00000047880 Cxcr5 481 ENSMUSG00000047953.7 ENSMUSG00000047953 Gp5 482 ENSMUSG00000048534.7 ENSMUSG00000048534 Jaml 483 ENSMUSG00000048621.3 ENSMUSG00000048621 Gm6377 484 ENSMUSG00000048806.4 ENSMUSG00000048806 Ifnb1 485 ENSMUSG00000048852.13 ENSMUSG00000048852 Gm12185 486 ENSMUSG00000049037.8 ENSMUSG00000049037 Clec4a1 487 ENSMUSG00000049092.11 ENSMUSG00000049092 Gpr137c 488 ENSMUSG00000049100.15 ENSMUSG00000049100 Pcdh10 489 ENSMUSG00000049130.6 ENSMUSG00000049130 C5ar1 490 ENSMUSG00000049313.8 ENSMUSG00000049313 Sorl1 491 ENSMUSG00000049653.5 ENSMUSG00000049653 Spatc1 492 ENSMUSG00000049694.13 ENSMUSG00000049694 BC048671 493 ENSMUSG00000049866.12 ENSMUSG00000049866 Arl4c 494 ENSMUSG00000049907.8 ENSMUSG00000049907 Rasl11b 495 ENSMUSG00000049988.5 ENSMUSG00000049988 Lrrc25 496 ENSMUSG00000050132.13 ENSMUSG00000050132 Sarm1 497 ENSMUSG00000050157.6 ENSMUSG00000050157 Gm867 498 ENSMUSG00000050248.11 ENSMUSG00000050248 Evc2

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

499 ENSMUSG00000050335.17 ENSMUSG00000050335 Lgals3 500 ENSMUSG00000050468.12 ENSMUSG00000050468 Astl 501 ENSMUSG00000050503.8 ENSMUSG00000050503 Fbxl22 502 ENSMUSG00000050578.10 ENSMUSG00000050578 Mmp13 503 ENSMUSG00000050751.14 ENSMUSG00000050751 Pgbd5 504 ENSMUSG00000050921.12 ENSMUSG00000050921 P2ry10 505 ENSMUSG00000050966.9 ENSMUSG00000050966 Lin28a 506 ENSMUSG00000051000.17 ENSMUSG00000051000 Fam160a1 507 ENSMUSG00000051335.6 ENSMUSG00000051335 Gfod1 508 ENSMUSG00000051354.14 ENSMUSG00000051354 Samd3 509 ENSMUSG00000051439.6 ENSMUSG00000051439 Cd14 510 ENSMUSG00000051490.2 ENSMUSG00000051490 Foxd4 511 ENSMUSG00000051504.18 ENSMUSG00000051504 Siglech 512 ENSMUSG00000051509.6 ENSMUSG00000051509 Olfr414 513 ENSMUSG00000051682.15 ENSMUSG00000051682 Treml4 514 ENSMUSG00000051748.2 ENSMUSG00000051748 Wfdc21 515 ENSMUSG00000052013.15 ENSMUSG00000052013 Btla 516 ENSMUSG00000052040.10 ENSMUSG00000052040 Klf13 517 ENSMUSG00000052117.5 ENSMUSG00000052117 D630039A03Rik 518 ENSMUSG00000052212.6 ENSMUSG00000052212 Cd177 519 ENSMUSG00000052270.7 ENSMUSG00000052270 Fpr2 520 ENSMUSG00000052305.6 ENSMUSG00000052305 Hbb-bs 521 ENSMUSG00000052477.15 ENSMUSG00000052477 C130026I21Rik 522 ENSMUSG00000052534.15 ENSMUSG00000052534 Pbx1 523 ENSMUSG00000052837.6 ENSMUSG00000052837 Junb 524 ENSMUSG00000052889.11 ENSMUSG00000052889 Prkcb 525 ENSMUSG00000053007.9 ENSMUSG00000053007 Creb5 526 ENSMUSG00000053044.8 ENSMUSG00000053044 Cd8b1 527 ENSMUSG00000053101.3 ENSMUSG00000053101 Gpr141 528 ENSMUSG00000053338.9 ENSMUSG00000053338 Tarm1 529 ENSMUSG00000053414.8 ENSMUSG00000053414 Hunk 530 ENSMUSG00000053560.4 ENSMUSG00000053560 Ier2 531 ENSMUSG00000053819.16 ENSMUSG00000053819 Camk2d 532 ENSMUSG00000053977.13 ENSMUSG00000053977 Cd8a 533 ENSMUSG00000054072.11 ENSMUSG00000054072 Iigp1 534 ENSMUSG00000054161.12 ENSMUSG00000054161 Fam83e 535 ENSMUSG00000054169.7 ENSMUSG00000054169 Ceacam10 536 ENSMUSG00000054435.16 ENSMUSG00000054435 Gimap4 537 ENSMUSG00000054855.13 ENSMUSG00000054855 Rnd1 538 ENSMUSG00000054905.2 ENSMUSG00000054905 Stfa3 539 ENSMUSG00000055216.3 ENSMUSG00000055216 9430025C20Rik 540 ENSMUSG00000055407.14 ENSMUSG00000055407 Map6 541 ENSMUSG00000055435.6 ENSMUSG00000055435 Maf 542 ENSMUSG00000055546.6 ENSMUSG00000055546 Timd4 543 ENSMUSG00000055978.5 ENSMUSG00000055978 Fut2 544 ENSMUSG00000056025.12 ENSMUSG00000056025 Clca3a1 545 ENSMUSG00000056054.9 ENSMUSG00000056054 S100a8 546 ENSMUSG00000056071.12 ENSMUSG00000056071 S100a9 547 ENSMUSG00000056498.13 ENSMUSG00000056498 Tmem154 548 ENSMUSG00000056529.7 ENSMUSG00000056529 Ptafr

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

549 ENSMUSG00000056537.11 ENSMUSG00000056537 Rlim 550 ENSMUSG00000056656.6 ENSMUSG00000056656 Apol8 551 ENSMUSG00000056708.5 ENSMUSG00000056708 Ier5 552 ENSMUSG00000057098.14 ENSMUSG00000057098 Ebf1 553 ENSMUSG00000057191.13 ENSMUSG00000057191 AB124611 554 ENSMUSG00000057337.13 ENSMUSG00000057337 Chst3 555 ENSMUSG00000058022.14 ENSMUSG00000058022 Adtrp 556 ENSMUSG00000058427.10 ENSMUSG00000058427 Cxcl2 557 ENSMUSG00000058755.3 ENSMUSG00000058755 Osm 558 ENSMUSG00000058818.13 ENSMUSG00000058818 Pirb 559 ENSMUSG00000059089.4 ENSMUSG00000059089 Fcgr4 560 ENSMUSG00000059108.4 ENSMUSG00000059108 Ifitm6 561 ENSMUSG00000059498.13 ENSMUSG00000059498 Fcgr3 562 ENSMUSG00000059657.5 ENSMUSG00000059657 Stfa2l1 563 ENSMUSG00000059901.12 ENSMUSG00000059901 Adamts14 564 ENSMUSG00000059994.10 ENSMUSG00000059994 Fcrl1 565 ENSMUSG00000060180.12 ENSMUSG00000060180 Myh13 566 ENSMUSG00000060445.11 ENSMUSG00000060445 Sycp2 567 ENSMUSG00000060548.13 ENSMUSG00000060548 Tnfrsf19 568 ENSMUSG00000060586.10 ENSMUSG00000060586 H2-Eb1 569 ENSMUSG00000061132.13 ENSMUSG00000061132 Blnk 570 ENSMUSG00000061311.6 ENSMUSG00000061311 Rag1 571 ENSMUSG00000061353.11 ENSMUSG00000061353 Cxcl12 572 ENSMUSG00000062157.6 ENSMUSG00000062157 Ifnlr1 573 ENSMUSG00000062345.10 ENSMUSG00000062345 Serpinb2 574 ENSMUSG00000062515.3 ENSMUSG00000062515 Fabp4 575 ENSMUSG00000063109.13 ENSMUSG00000063109 Dgkeos 576 ENSMUSG00000063171.4 ENSMUSG00000063171 Rps4l 577 ENSMUSG00000063177.6 ENSMUSG00000063177 Klk1b27 578 ENSMUSG00000063894.15 ENSMUSG00000063894 Zkscan8 579 ENSMUSG00000063903.5 ENSMUSG00000063903 Klk1 580 ENSMUSG00000064065.15 ENSMUSG00000064065 Ipcef1 581 ENSMUSG00000064246.10 ENSMUSG00000064246 Chil1 582 ENSMUSG00000064337.1 ENSMUSG00000064337 mt-Rnr1 583 ENSMUSG00000065634.1 ENSMUSG00000065634 Gm24252 584 ENSMUSG00000066677.12 ENSMUSG00000066677 Ifi208 585 ENSMUSG00000066682.11 ENSMUSG00000066682 Pilrb2 586 ENSMUSG00000066684.10 ENSMUSG00000066684 Pilrb1 587 ENSMUSG00000067149.6 ENSMUSG00000067149 Jchain 588 ENSMUSG00000067297.4 ENSMUSG00000067297 Ifit1bl2 589 ENSMUSG00000067613.6 ENSMUSG00000067613 Krt83 590 ENSMUSG00000068105.11 ENSMUSG00000068105 Tnfrsf13c 591 ENSMUSG00000068227.9 ENSMUSG00000068227 Il2rb 592 ENSMUSG00000069114.8 ENSMUSG00000069114 Zbtb10 593 ENSMUSG00000069515.6 ENSMUSG00000069515 Lyz1 594 ENSMUSG00000069516.8 ENSMUSG00000069516 Lyz2 595 ENSMUSG00000069662.5 ENSMUSG00000069662 Marcks 596 ENSMUSG00000069833.12 ENSMUSG00000069833 Ahnak 597 ENSMUSG00000069867.3 ENSMUSG00000069867 Pabpn1l 598 ENSMUSG00000069873.4 ENSMUSG00000069873 4930438A08Rik

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

599 ENSMUSG00000069919.7 ENSMUSG00000069919 Hba-a1 600 ENSMUSG00000070304.12 ENSMUSG00000070304 Scn2b 601 ENSMUSG00000070576.4 ENSMUSG00000070576 Mn1 602 ENSMUSG00000070873.5 ENSMUSG00000070873 Lilra5 603 ENSMUSG00000070979.5 ENSMUSG00000070979 Actl7a 604 ENSMUSG00000071489.1 ENSMUSG00000071489 Ptgdr 605 ENSMUSG00000071561.2 ENSMUSG00000071561 BC100530 606 ENSMUSG00000072214.7 ENSMUSG00000072214 43713 607 ENSMUSG00000072589.4 ENSMUSG00000072589 Gm10371 608 ENSMUSG00000072596.4 ENSMUSG00000072596 Ear2 609 ENSMUSG00000072599.3 ENSMUSG00000072599 Ear-ps2 610 ENSMUSG00000072601.4 ENSMUSG00000072601 Ear1 611 ENSMUSG00000072620.3 ENSMUSG00000072620 Slfn2 612 ENSMUSG00000072844.6 ENSMUSG00000072844 G530011O06Rik 613 ENSMUSG00000072875.2 ENSMUSG00000072875 Gpr27 614 ENSMUSG00000073063.3 ENSMUSG00000073063 Hbq1b 615 ENSMUSG00000073386.5 ENSMUSG00000073386 9830107B12Rik 616 ENSMUSG00000073421.5 ENSMUSG00000073421 H2-Ab1 617 ENSMUSG00000073678.4 ENSMUSG00000073678 Pgap1 618 ENSMUSG00000073940.3 ENSMUSG00000073940 Hbb-bt 619 ENSMUSG00000074063.10 ENSMUSG00000074063 Osgin1 620 ENSMUSG00000074121.3 ENSMUSG00000074121 Ntf5 621 ENSMUSG00000074151.13 ENSMUSG00000074151 Nlrc5 622 ENSMUSG00000074259.10 ENSMUSG00000074259 Gramd2 623 ENSMUSG00000074272.10 ENSMUSG00000074272 Ceacam1 624 ENSMUSG00000074417.9 ENSMUSG00000074417 Gm14548 625 ENSMUSG00000074419.11 ENSMUSG00000074419 Gm15448 626 ENSMUSG00000074569.4 ENSMUSG00000074569 Gcnt7 627 ENSMUSG00000074570.14 ENSMUSG00000074570 Cass4 628 ENSMUSG00000074622.4 ENSMUSG00000074622 Mafb 629 ENSMUSG00000074677.11 ENSMUSG00000074677 Sirpb1c 630 ENSMUSG00000074794.10 ENSMUSG00000074794 Arrdc3 631 ENSMUSG00000075184.3 ENSMUSG00000075184 F930017D23Rik 632 ENSMUSG00000075327.10 ENSMUSG00000075327 Zbtb2 633 ENSMUSG00000075370.12 ENSMUSG00000075370 Igll1 634 ENSMUSG00000076498.2 ENSMUSG00000076498 Trbc2 635 ENSMUSG00000076523.2 ENSMUSG00000076523 Igkv15-103 636 ENSMUSG00000076525.3 ENSMUSG00000076525 Igkv1-99 637 ENSMUSG00000076534.6 ENSMUSG00000076534 Igkv12-89 638 ENSMUSG00000076536.3 ENSMUSG00000076536 Igkv4-86 639 ENSMUSG00000076538.1 ENSMUSG00000076538 Igkv13-84 640 ENSMUSG00000076541.3 ENSMUSG00000076541 Igkv4-79 641 ENSMUSG00000076543.2 ENSMUSG00000076543 Igkv4-74 642 ENSMUSG00000076547.2 ENSMUSG00000076547 Igkv4-70 643 ENSMUSG00000076549.2 ENSMUSG00000076549 Igkv4-68 644 ENSMUSG00000076552.3 ENSMUSG00000076552 Igkv4-61 645 ENSMUSG00000076555.3 ENSMUSG00000076555 Igkv4-57-1 646 ENSMUSG00000076556.3 ENSMUSG00000076556 Igkv4-57 647 ENSMUSG00000076575.6 ENSMUSG00000076575 Igkv7-33 648 ENSMUSG00000076576.2 ENSMUSG00000076576 Igkv6-32

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

649 ENSMUSG00000076583.1 ENSMUSG00000076583 Igkv8-24 650 ENSMUSG00000076587.3 ENSMUSG00000076587 Igkv6-20 651 ENSMUSG00000076589.2 ENSMUSG00000076589 Igkv8-18 652 ENSMUSG00000076605.2 ENSMUSG00000076605 Igkj2 653 ENSMUSG00000076606.3 ENSMUSG00000076606 Igkj3 654 ENSMUSG00000076607.1 ENSMUSG00000076607 Igkj4 655 ENSMUSG00000076608.2 ENSMUSG00000076608 Igkj5 656 ENSMUSG00000076609.2 ENSMUSG00000076609 Igkc 657 ENSMUSG00000076613.4 ENSMUSG00000076613 Ighg2b 658 ENSMUSG00000076617.9 ENSMUSG00000076617 Ighm 659 ENSMUSG00000076618.1 ENSMUSG00000076618 Ighj4 660 ENSMUSG00000076633.7 ENSMUSG00000076633 Ighv5-2 661 ENSMUSG00000076665.4 ENSMUSG00000076665 Ighv7-1 662 ENSMUSG00000076666.2 ENSMUSG00000076666 Ighv14-4 663 ENSMUSG00000076674.2 ENSMUSG00000076674 Ighv3-8 664 ENSMUSG00000076676.2 ENSMUSG00000076676 Ighv12-3 665 ENSMUSG00000076677.1 ENSMUSG00000076677 Ighv6-3 666 ENSMUSG00000076680.1 ENSMUSG00000076680 Ighv6-6 667 ENSMUSG00000076695.7 ENSMUSG00000076695 Ighv1-18 668 ENSMUSG00000076710.2 ENSMUSG00000076710 Ighv1-49 669 ENSMUSG00000076928.5 ENSMUSG00000076928 Trac 670 ENSMUSG00000076934.2 ENSMUSG00000076934 Iglv1 671 ENSMUSG00000076939.2 ENSMUSG00000076939 Iglv3 672 ENSMUSG00000078554.2 ENSMUSG00000078554 Fam229a 673 ENSMUSG00000078763.2 ENSMUSG00000078763 Slfn1 674 ENSMUSG00000078771.10 ENSMUSG00000078771 Evi2a 675 ENSMUSG00000078780.7 ENSMUSG00000078780 Gm5150 676 ENSMUSG00000078816.9 ENSMUSG00000078816 Prkcg 677 ENSMUSG00000078817.4 ENSMUSG00000078817 Nlrp12 678 ENSMUSG00000078853.8 ENSMUSG00000078853 Igtp 679 ENSMUSG00000078920.3 ENSMUSG00000078920 Ifi47 680 ENSMUSG00000078921.3 ENSMUSG00000078921 Tgtp2 681 ENSMUSG00000078922.9 ENSMUSG00000078922 Tgtp1 682 ENSMUSG00000079022.10 ENSMUSG00000079022 Col22a1 683 ENSMUSG00000079164.8 ENSMUSG00000079164 Tlr5 684 ENSMUSG00000079293.11 ENSMUSG00000079293 Clec7a 685 ENSMUSG00000079455.9 ENSMUSG00000079455 Gm16026 686 ENSMUSG00000079470.8 ENSMUSG00000079470 Utp14b 687 ENSMUSG00000079481.11 ENSMUSG00000079481 Nhsl2 688 ENSMUSG00000079597.2 ENSMUSG00000079597 Gm5483 689 ENSMUSG00000080738.1 ENSMUSG00000080738 Mup-ps22 690 ENSMUSG00000081665.2 ENSMUSG00000081665 Gm15922 691 ENSMUSG00000081723.1 ENSMUSG00000081723 Gm15931 692 ENSMUSG00000082101.3 ENSMUSG00000082101 Slfn14 693 ENSMUSG00000082141.1 ENSMUSG00000082141 Gm11212 694 ENSMUSG00000082292.3 ENSMUSG00000082292 Gm12250 695 ENSMUSG00000083207.1 ENSMUSG00000083207 Gm14780 696 ENSMUSG00000083533.2 ENSMUSG00000083533 Gm13450 697 ENSMUSG00000083650.1 ENSMUSG00000083650 Gm13357 698 ENSMUSG00000083677.1 ENSMUSG00000083677 Gm11699

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

699 ENSMUSG00000084224.1 ENSMUSG00000084224 Gm12337 700 ENSMUSG00000084960.1 ENSMUSG00000084960 B430010I23Rik 701 ENSMUSG00000085148.1 ENSMUSG00000085148 Mir22hg 702 ENSMUSG00000085205.1 ENSMUSG00000085205 Gm13185 703 ENSMUSG00000085645.1 ENSMUSG00000085645 Hoxb5os 704 ENSMUSG00000085672.1 ENSMUSG00000085672 Gm16193 705 ENSMUSG00000086111.1 ENSMUSG00000086111 Gm15326 706 ENSMUSG00000086425.7 ENSMUSG00000086425 F730016J06Rik 707 ENSMUSG00000086564.9 ENSMUSG00000086564 Cd101 708 ENSMUSG00000086765.7 ENSMUSG00000086765 Gm11827 709 ENSMUSG00000087113.1 ENSMUSG00000087113 Gm11714 710 ENSMUSG00000087131.7 ENSMUSG00000087131 Gm16152 711 ENSMUSG00000087193.7 ENSMUSG00000087193 Gm14820 712 ENSMUSG00000087199.1 ENSMUSG00000087199 Gm15818 713 ENSMUSG00000087263.1 ENSMUSG00000087263 Gm15726 714 ENSMUSG00000089809.9 ENSMUSG00000089809 Rasgef1b 715 ENSMUSG00000089931.1 ENSMUSG00000089931 Gm8459 716 ENSMUSG00000089942.9 ENSMUSG00000089942 Pira2 717 ENSMUSG00000090166.2 ENSMUSG00000090166 Ear10 718 ENSMUSG00000090192.1 ENSMUSG00000090192 Gm16556 719 ENSMUSG00000090252.1 ENSMUSG00000090252 Gm16028 720 ENSMUSG00000090307.7 ENSMUSG00000090307 1700071M16Rik 721 ENSMUSG00000090387.1 ENSMUSG00000090387 Gm17056 722 ENSMUSG00000090439.3 ENSMUSG00000090439 Gm17455 723 ENSMUSG00000090628.1 ENSMUSG00000090628 Gm17083 724 ENSMUSG00000090665.2 ENSMUSG00000090665 Gad1-ps 725 ENSMUSG00000090698.2 ENSMUSG00000090698 Apold1 726 ENSMUSG00000090785.1 ENSMUSG00000090785 Gm17116 727 ENSMUSG00000091017.1 ENSMUSG00000091017 Fam71a 728 ENSMUSG00000091345.9 ENSMUSG00000091345 Col6a5 729 ENSMUSG00000091694.9 ENSMUSG00000091694 Apol11b 730 ENSMUSG00000092341.2 ENSMUSG00000092341 Malat1 731 ENSMUSG00000092495.1 ENSMUSG00000092495 Gm20405 732 ENSMUSG00000092517.1 ENSMUSG00000092517 Art2a-ps 733 ENSMUSG00000093327.1 ENSMUSG00000093327 Mir5107 734 ENSMUSG00000093598.1 ENSMUSG00000093598 A730085K08Rik 735 ENSMUSG00000093861.2 ENSMUSG00000093861 Igkv1-110 736 ENSMUSG00000093894.1 ENSMUSG00000093894 Ighv1-53 737 ENSMUSG00000093906.5 ENSMUSG00000093906 Igkv9-129 738 ENSMUSG00000093955.2 ENSMUSG00000093955 Ighv1-34 739 ENSMUSG00000093973.1 ENSMUSG00000093973 Mrgpra2a 740 ENSMUSG00000094029.2 ENSMUSG00000094029 Ighv3-3 741 ENSMUSG00000094088.2 ENSMUSG00000094088 Ighv1-64 742 ENSMUSG00000094124.5 ENSMUSG00000094124 Ighv1-74 743 ENSMUSG00000094134.2 ENSMUSG00000094134 Ighv5-15 744 ENSMUSG00000094194.2 ENSMUSG00000094194 Ighv5-16 745 ENSMUSG00000094335.2 ENSMUSG00000094335 Igkv1-117 746 ENSMUSG00000094356.2 ENSMUSG00000094356 Igkv8-28 747 ENSMUSG00000094420.2 ENSMUSG00000094420 Igkv10-96 748 ENSMUSG00000094433.2 ENSMUSG00000094433 Igkv5-43

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

749 ENSMUSG00000094626.1 ENSMUSG00000094626 Tmem121b 750 ENSMUSG00000094689.1 ENSMUSG00000094689 Ighv1-81 751 ENSMUSG00000094797.1 ENSMUSG00000094797 Igkv6-15 752 ENSMUSG00000094872.1 ENSMUSG00000094872 Igkv9-120 753 ENSMUSG00000094930.2 ENSMUSG00000094930 Igkv6-25 754 ENSMUSG00000094951.1 ENSMUSG00000094951 Ighv5-6 755 ENSMUSG00000095028.6 ENSMUSG00000095028 Sirpb1b 756 ENSMUSG00000095061.1 ENSMUSG00000095061 E030018B13Rik 757 ENSMUSG00000095079.6 ENSMUSG00000095079 Igha 758 ENSMUSG00000095105.2 ENSMUSG00000095105 Edaradd 759 ENSMUSG00000095170.2 ENSMUSG00000095170 Ighv8-11 760 ENSMUSG00000095200.2 ENSMUSG00000095200 Ighv1-7 761 ENSMUSG00000095210.2 ENSMUSG00000095210 Ighv5-9-1 762 ENSMUSG00000095285.2 ENSMUSG00000095285 Ighv5-9 763 ENSMUSG00000095335.2 ENSMUSG00000095335 Igkv3-5 764 ENSMUSG00000095351.2 ENSMUSG00000095351 Igkv3-2 765 ENSMUSG00000095416.6 ENSMUSG00000095416 Ighv1-12 766 ENSMUSG00000095429.1 ENSMUSG00000095429 Ighv5-12 767 ENSMUSG00000095442.1 ENSMUSG00000095442 Ighv1-4 768 ENSMUSG00000095571.2 ENSMUSG00000095571 Ighv5-17 769 ENSMUSG00000095589.2 ENSMUSG00000095589 Ighv1-55 770 ENSMUSG00000095612.2 ENSMUSG00000095612 Ighv5-4 771 ENSMUSG00000095630.2 ENSMUSG00000095630 Igkv6-23 772 ENSMUSG00000095633.2 ENSMUSG00000095633 Igkv4-58 773 ENSMUSG00000095642.3 ENSMUSG00000095642 Ighv14-3 774 ENSMUSG00000095761.6 ENSMUSG00000095761 Ighv1-20 775 ENSMUSG00000095788.6 ENSMUSG00000095788 Sirpb1a 776 ENSMUSG00000095866.1 ENSMUSG00000095866 Ighv2-4 777 ENSMUSG00000095923.6 ENSMUSG00000095923 Ighv1-37 778 ENSMUSG00000095981.1 ENSMUSG00000095981 Ighv10-1 779 ENSMUSG00000096054.3 ENSMUSG00000096054 Syne1 780 ENSMUSG00000096150.1 ENSMUSG00000096150 Ighv1-85 781 ENSMUSG00000096210.2 ENSMUSG00000096210 H1f0 782 ENSMUSG00000096326.2 ENSMUSG00000096326 Ighv1-78 783 ENSMUSG00000096336.2 ENSMUSG00000096336 Igkv1-135 784 ENSMUSG00000096422.2 ENSMUSG00000096422 Igkv12-44 785 ENSMUSG00000096452.2 ENSMUSG00000096452 Ighv1-77 786 ENSMUSG00000096461.5 ENSMUSG00000096461 Igkv14-130 787 ENSMUSG00000096464.2 ENSMUSG00000096464 Ighv2-2 788 ENSMUSG00000096499.2 ENSMUSG00000096499 Ighv1-5 789 ENSMUSG00000096515.5 ENSMUSG00000096515 Igkv14-100 790 ENSMUSG00000096594.2 ENSMUSG00000096594 Igkv8-19 791 ENSMUSG00000096632.2 ENSMUSG00000096632 Igkv9-124 792 ENSMUSG00000096844.1 ENSMUSG00000096844 Igkv6-14 793 ENSMUSG00000096929.7 ENSMUSG00000096929 A330023F24Rik 794 ENSMUSG00000097219.1 ENSMUSG00000097219 Gm26551 795 ENSMUSG00000097223.2 ENSMUSG00000097223 Gm2449 796 ENSMUSG00000097266.1 ENSMUSG00000097266 Gm26802 797 ENSMUSG00000097275.1 ENSMUSG00000097275 Gm26648 798 ENSMUSG00000097418.7 ENSMUSG00000097418 Mir155hg

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

799 ENSMUSG00000097472.1 ENSMUSG00000097472 Gm26586 800 ENSMUSG00000097636.7 ENSMUSG00000097636 Mirt1 801 ENSMUSG00000097665.1 ENSMUSG00000097665 Gm16853 802 ENSMUSG00000097754.1 ENSMUSG00000097754 Ptgs2os2 803 ENSMUSG00000097779.1 ENSMUSG00000097779 4833407H14Rik 804 ENSMUSG00000097814.5 ENSMUSG00000097814 Panct2 805 ENSMUSG00000097840.1 ENSMUSG00000097840 Gm26756 806 ENSMUSG00000097899.2 ENSMUSG00000097899 Gm16894 807 ENSMUSG00000098043.1 ENSMUSG00000098043 Gm26980 808 ENSMUSG00000098188.1 ENSMUSG00000098188 Sowahc 809 ENSMUSG00000098224.1 ENSMUSG00000098224 Gm7985 810 ENSMUSG00000099032.2 ENSMUSG00000099032 Tcf24 811 ENSMUSG00000099216.1 ENSMUSG00000099216 Obox8 812 ENSMUSG00000099773.1 ENSMUSG00000099773 Hmgb1-rs16 813 ENSMUSG00000100147.2 ENSMUSG00000100147 1700047M11Rik 814 ENSMUSG00000100658.1 ENSMUSG00000100658 F730311O21Rik 815 ENSMUSG00000101122.1 ENSMUSG00000101122 Gm17971 816 ENSMUSG00000101517.6 ENSMUSG00000101517 4732465J04Rik 817 ENSMUSG00000101930.1 ENSMUSG00000101930 Gm5441 818 ENSMUSG00000102051.1 ENSMUSG00000102051 I830127L07Rik 819 ENSMUSG00000102258.1 ENSMUSG00000102258 Gm38257 820 ENSMUSG00000102364.1 ENSMUSG00000102364 Ighv8-5 821 ENSMUSG00000102512.1 ENSMUSG00000102512 Ighv1-29 822 ENSMUSG00000102556.1 ENSMUSG00000102556 Gm37569 823 ENSMUSG00000102919.1 ENSMUSG00000102919 Gm37726 824 ENSMUSG00000102942.1 ENSMUSG00000102942 Ighv1-33 825 ENSMUSG00000102964.1 ENSMUSG00000102964 9430034N14Rik 826 ENSMUSG00000102975.1 ENSMUSG00000102975 Gm37347 827 ENSMUSG00000103094.1 ENSMUSG00000103094 Gm37558 828 ENSMUSG00000103197.1 ENSMUSG00000103197 Gm37642 829 ENSMUSG00000103254.1 ENSMUSG00000103254 Ighv1-15 830 ENSMUSG00000103290.1 ENSMUSG00000103290 Ighv1-23 831 ENSMUSG00000103303.1 ENSMUSG00000103303 Gm37802 832 ENSMUSG00000103320.1 ENSMUSG00000103320 Gm37403 833 ENSMUSG00000103591.1 ENSMUSG00000103591 Gm38365 834 ENSMUSG00000103783.1 ENSMUSG00000103783 Gm37522 835 ENSMUSG00000103821.1 ENSMUSG00000103821 D430013B06Rik 836 ENSMUSG00000103869.1 ENSMUSG00000103869 Gm37420 837 ENSMUSG00000103939.1 ENSMUSG00000103939 Ighv3-4 838 ENSMUSG00000103995.1 ENSMUSG00000103995 5730488B01Rik 839 ENSMUSG00000104117.5 ENSMUSG00000104117 Gm20743 840 ENSMUSG00000104213.5 ENSMUSG00000104213 Ighd 841 ENSMUSG00000104293.1 ENSMUSG00000104293 Gm38043 842 ENSMUSG00000104347.1 ENSMUSG00000104347 Gm37689 843 ENSMUSG00000104413.1 ENSMUSG00000104413 Gm37065 844 ENSMUSG00000104452.1 ENSMUSG00000104452 Ighv8-8 845 ENSMUSG00000104693.1 ENSMUSG00000104693 Gm42941 846 ENSMUSG00000104872.1 ENSMUSG00000104872 1700008B11Rik 847 ENSMUSG00000104927.1 ENSMUSG00000104927 Gm43388 848 ENSMUSG00000105128.1 ENSMUSG00000105128 Gm42870

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

849 ENSMUSG00000105137.1 ENSMUSG00000105137 Gm42869 850 ENSMUSG00000105326.1 ENSMUSG00000105326 6030400A10Rik 851 ENSMUSG00000105341.1 ENSMUSG00000105341 Gm43817 852 ENSMUSG00000105434.1 ENSMUSG00000105434 Gm43359 853 ENSMUSG00000105457.1 ENSMUSG00000105457 Gm43200 854 ENSMUSG00000105517.1 ENSMUSG00000105517 Gm42436 855 ENSMUSG00000105547.1 ENSMUSG00000105547 Iglc3 856 ENSMUSG00000105605.1 ENSMUSG00000105605 Ighv1-86 857 ENSMUSG00000105606.1 ENSMUSG00000105606 Igkv2-109 858 ENSMUSG00000105646.1 ENSMUSG00000105646 Gm30211 859 ENSMUSG00000105757.1 ENSMUSG00000105757 Ighv1-83 860 ENSMUSG00000105906.1 ENSMUSG00000105906 Iglc1 861 ENSMUSG00000106108.1 ENSMUSG00000106108 Gm43221 862 ENSMUSG00000106149.1 ENSMUSG00000106149 Gm43430 863 ENSMUSG00000106166.1 ENSMUSG00000106166 Gm43484 864 ENSMUSG00000106427.1 ENSMUSG00000106427 Gm42820 865 ENSMUSG00000106609.1 ENSMUSG00000106609 Gm43181 866 ENSMUSG00000106832.1 ENSMUSG00000106832 Gm42632 867 ENSMUSG00000107733.1 ENSMUSG00000107733 Gm8774 868 ENSMUSG00000107756.1 ENSMUSG00000107756 Gm44164 869 ENSMUSG00000107760.1 ENSMUSG00000107760 Gm44401 870 ENSMUSG00000108137.1 ENSMUSG00000108137 Gm44053 871 ENSMUSG00000108207.2 ENSMUSG00000108207 1810059H22Rik 872 ENSMUSG00000108238.1 ENSMUSG00000108238 Gm43984 873 ENSMUSG00000108291.1 ENSMUSG00000108291 Gm44292 874 ENSMUSG00000108353.1 ENSMUSG00000108353 Gm45205 875 ENSMUSG00000108741.1 ENSMUSG00000108741 Gm44553 876 ENSMUSG00000108777.1 ENSMUSG00000108777 Gm45081 877 ENSMUSG00000109005.1 ENSMUSG00000109005 Gm45221 878 ENSMUSG00000109110.1 ENSMUSG00000109110 Gm45014 879 ENSMUSG00000109864.1 ENSMUSG00000109864 Eid3 880 ENSMUSG00000109921.1 ENSMUSG00000109921 Gm33326 881 ENSMUSG00000110125.1 ENSMUSG00000110125 Gm33148 882 ENSMUSG00000110148.1 ENSMUSG00000110148 5830408C22Rik 883 ENSMUSG00000110377.1 ENSMUSG00000110377 Gm45363 884 ENSMUSG00000110588.1 ENSMUSG00000110588 Gm45774 885 ENSMUSG00000110622.1 ENSMUSG00000110622 Iqcn 886 ENSMUSG00000111167.1 ENSMUSG00000111167 Gm39321 887 ENSMUSG00000111212.1 ENSMUSG00000111212 Gm47087 888 ENSMUSG00000111264.1 ENSMUSG00000111264 E030022I16Rik 889 ENSMUSG00000111422.1 ENSMUSG00000111422 1700027J07Rik 890 ENSMUSG00000111514.1 ENSMUSG00000111514 E230014E18Rik 891 ENSMUSG00000112023.1 ENSMUSG00000112023 Lilr4b 892 ENSMUSG00000112148.1 ENSMUSG00000112148 Lilrb4a 893 ENSMUSG00000112722.1 ENSMUSG00000112722 Gm3942 894 ENSMUSG00000113184.1 ENSMUSG00000113184 AC125351.1 895 ENSMUSG00000113701.1 ENSMUSG00000113701 B230303A05Rik 896 ENSMUSG00000114537.1 ENSMUSG00000114537 Gm48569 897 ENSMUSG00000114554.1 ENSMUSG00000114554 5430425K12Rik 898 ENSMUSG00000115574.1 ENSMUSG00000115574 Gm49245

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

899 ENSMUSG00000115747.1 ENSMUSG00000115747 Gm49145 900 ENSMUSG00000115869.1 ENSMUSG00000115869 Gm31814 901 ENSMUSG00000115919.1 ENSMUSG00000115919 Gm31583 902 ENSMUSG00000115946.2 ENSMUSG00000115946 Mirt2 903 ENSMUSG00000116380.1 ENSMUSG00000116380 Gm39556 904 ENSMUSG00000116409.1 ENSMUSG00000116409 Gm34095 905 ENSMUSG00000116641.1 ENSMUSG00000116641 AC165271.1 906 ENSMUSG00000116738.1 ENSMUSG00000116738 CT009627.2 907 ENSMUSG00000117318.1 ENSMUSG00000117318 AC241601.2

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

Bone Marrow-Derived CMP cells from Gene.type Chromosome/scaffold.name Gene.start.(bp) protein_coding 13 5861482 protein_coding 16 96422288 protein_coding 11 83175186 protein_coding 11 74830920 protein_coding 10 77530252 protein_coding X 166523007 protein_coding 4 129489014 protein_coding 15 101224188 protein_coding 6 82911885 protein_coding 4 134082448 protein_coding 11 96292476 protein_coding 10 75943057 protein_coding 11 83647844 protein_coding 3 90612882 protein_coding 11 106318592 protein_coding 6 86647042 protein_coding 8 8617434 protein_coding 10 77052178 protein_coding 11 97098071 protein_coding 11 94936224 protein_coding 11 95044474 protein_coding 12 40201567 protein_coding 9 37528078 protein_coding X 73774405 protein_coding 9 44969572 protein_coding 7 16308393 protein_coding 17 24727820 protein_coding 12 112907819 protein_coding 7 19606217 protein_coding 4 55527143 protein_coding 2 153108468 protein_coding 7 24897381 protein_coding 8 71988482 protein_coding 15 9505788 protein_coding 7 43524216 protein_coding 11 9191942 protein_coding 17 57358691 protein_coding 17 28769297 protein_coding 6 106710357 protein_coding 8 75093621 protein_coding 8 3681737 protein_coding 9 7558456 protein_coding 2 172977700 protein_coding 7 4460674 protein_coding 4 94739289 lincRNA 2 167691177 protein_coding 11 102348824 protein_coding 4 136143497

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 7 44525993 protein_coding 10 77907722 protein_coding 8 33516738 protein_coding 1 193272161 protein_coding 11 46055992 protein_coding 5 7960457 protein_coding 9 14541966 protein_coding 8 3665754 protein_coding 4 44524757 protein_coding 14 63372836 protein_coding 6 129831154 protein_coding 6 88193891 protein_coding 2 25399351 protein_coding 12 80167547 protein_coding 1 171917515 protein_coding 1 171767127 protein_coding X 9435252 protein_coding 13 43784775 protein_coding 5 134220053 protein_coding 1 131019845 protein_coding 13 24327404 protein_coding 2 164424247 protein_coding X 36112110 protein_coding 2 51130438 protein_coding 11 98036623 protein_coding 2 15049395 protein_coding 2 165055627 protein_coding 2 164940780 protein_coding 2 164839518 protein_coding 11 98464902 protein_coding 11 69398508 protein_coding 11 55394500 protein_coding 11 84518284 protein_coding 7 142460809 protein_coding 11 70344152 protein_coding 11 83587882 protein_coding 11 83662584 protein_coding 6 54501173 protein_coding 11 98446394 protein_coding 10 19000910 protein_coding 10 43950636 protein_coding 10 103367783 protein_coding 10 89574020 protein_coding 10 99263231 protein_coding 10 21882184 protein_coding 10 24915221 protein_coding 10 23851462 protein_coding 10 87858265 protein_coding 10 60346851 protein_coding 10 117629500

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 10 111506286 protein_coding 11 23736847 protein_coding 11 31872211 protein_coding 11 46325150 protein_coding 11 4938754 protein_coding 11 46396559 protein_coding 1 134075170 protein_coding 12 7977648 protein_coding 12 24651274 protein_coding 11 105967945 protein_coding 11 82388900 protein_coding 11 73304992 protein_coding 11 76019194 protein_coding 11 69095217 protein_coding 12 91384563 protein_coding 12 55489410 protein_coding 12 79130777 protein_coding 12 112850873 protein_coding 13 30749226 protein_coding 13 41309581 protein_coding 13 34627834 protein_coding 13 110395046 protein_coding 14 31359880 protein_coding 14 60373259 protein_coding 14 76414961 protein_coding 14 78277445 protein_coding 14 79984081 protein_coding 14 66135039 protein_coding 14 70890120 protein_coding 14 103046977 protein_coding 14 55769057 protein_coding 15 39745930 protein_coding 15 61985391 protein_coding 15 56665627 protein_coding 15 80287238 protein_coding 15 97975602 protein_coding 16 10959275 protein_coding 16 23965052 protein_coding 16 26356642 protein_coding 16 4081328 protein_coding 15 76502015 protein_coding 15 75155240 protein_coding 16 48872621 protein_coding 16 19760208 protein_coding 16 44240180 protein_coding 16 33794037 protein_coding 16 85793827 protein_coding 16 95702075 protein_coding 16 36693978 protein_coding 15 98770712

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 15 101254269 protein_coding 17 29090976 protein_coding 13 113093825 protein_coding 6 124864692 protein_coding 17 23628311 protein_coding 17 43568098 protein_coding 17 45555703 protein_coding 17 46016993 protein_coding 17 31844248 protein_coding 17 73883895 protein_coding 17 79051906 protein_coding 17 57203970 protein_coding 18 35647266 protein_coding 17 35199381 protein_coding 18 66458604 protein_coding 18 60803848 protein_coding 19 20373428 protein_coding 19 10718143 protein_coding 19 11249675 protein_coding 19 11067471 protein_coding 19 10839727 protein_coding 19 34122549 protein_coding 19 3913493 protein_coding 19 5704367 protein_coding 8 39581685 protein_coding 19 58235604 protein_coding 19 59260878 protein_coding 11 120948480 protein_coding 19 46304737 protein_coding X 150547375 protein_coding 8 121729623 protein_coding 4 140745865 protein_coding 7 139978932 protein_coding 14 121035200 protein_coding 6 31519488 protein_coding 9 108991778 protein_coding 6 116410077 protein_coding 9 123962124 protein_coding 18 75367529 protein_coding 9 5345430 protein_coding 1 9968624 protein_coding 1 60887000 protein_coding 1 60716800 protein_coding 1 45374321 protein_coding 1 40465552 protein_coding 1 40074079 protein_coding 1 53755506 protein_coding 1 36761798 protein_coding 1 74375195 protein_coding 1 74153989

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 1 71585520 protein_coding 1 84905898 protein_coding 1 143999338 protein_coding 1 140084708 protein_coding 1 134111242 protein_coding 1 152800194 protein_coding 1 164437109 protein_coding 1 195136811 protein_coding 1 191170296 protein_coding 2 14229392 protein_coding 2 11642807 protein_coding 2 32384633 protein_coding 2 57106830 protein_coding 2 58129137 protein_coding 2 28076378 protein_coding 2 35256380 protein_coding 2 62664285 protein_coding 2 26457903 protein_coding 2 25624666 protein_coding 2 24336853 protein_coding 2 69380445 protein_coding 2 119751320 protein_coding 2 119351229 protein_coding 2 131069220 protein_coding 2 117279993 protein_coding 2 133552159 protein_coding 2 128126038 protein_coding 2 129364570 protein_coding 2 130012349 protein_coding 2 172472520 protein_coding 3 31095058 protein_coding 3 49892526 protein_coding 3 57455649 protein_coding 3 102775465 protein_coding 3 101275899 protein_coding 3 93520488 protein_coding 3 116109949 protein_coding 3 114030540 protein_coding 3 131110471 protein_coding 3 83836272 protein_coding 3 129804408 protein_coding 3 129269175 protein_coding 3 87846755 protein_coding 3 95499256 protein_coding 3 122294136 protein_coding 3 121723537 protein_coding 3 145922804 protein_coding 4 11156431 protein_coding 4 11704457 protein_coding 4 19876841

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 4 48045153 protein_coding 4 43446462 protein_coding 4 43482081 protein_coding 4 102087543 protein_coding 4 117128655 protein_coding 4 117096075 protein_coding 4 129058271 protein_coding 4 132974095 protein_coding 5 43818885 protein_coding 5 43868553 protein_coding 5 36017180 protein_coding 5 37289098 protein_coding 5 32135801 protein_coding 5 100845713 protein_coding 5 91139599 protein_coding 5 90891241 protein_coding 5 93267257 protein_coding 5 92006074 protein_coding 9 123678439 protein_coding 5 120680202 protein_coding 6 87383256 protein_coding 6 99711299 protein_coding 6 108660629 protein_coding 6 121343076 protein_coding 6 123281789 protein_coding 6 123262111 protein_coding 6 123106428 protein_coding 6 129267325 protein_coding 6 129485244 protein_coding 6 129666015 transcribed_unprocessed_pseudogene 6 130290878 protein_coding 6 131219223 protein_coding 6 135362545 protein_coding 6 136612070 protein_coding 6 142821545 protein_coding 7 19282624 protein_coding 7 18871331 protein_coding 7 3908280 protein_coding 7 43408204 protein_coding 7 43651070 protein_coding 7 49631499 protein_coding 7 88430273 protein_coding 7 30865402 protein_coding 7 29134851 protein_coding 7 126408450 protein_coding 7 123475384 protein_coding 7 128062640 protein_coding 7 110850607 protein_coding X 160390690 protein_coding X 73483602

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding X 73853778 protein_coding 8 3743397 protein_coding 8 3871824 protein_coding 8 10006467 protein_coding 8 57455923 protein_coding 8 94329201 protein_coding 8 72134975 protein_coding 8 120114152 protein_coding 8 119992438 protein_coding 8 104101625 protein_coding 8 104628070 protein_coding 9 7848699 protein_coding 9 40894849 protein_coding 9 32636221 protein_coding 9 51213708 protein_coding 9 44998740 protein_coding 9 44981786 protein_coding 9 37227585 protein_coding 9 44134469 protein_coding 9 21723483 protein_coding 9 92275602 protein_coding 9 118478212 protein_coding 9 110419747 protein_coding 1 150100031 protein_coding 9 111019271 protein_coding 15 59648350 protein_coding 9 119971163 protein_coding 9 105989454 protein_coding 11 59541568 protein_coding 2 103566310 protein_coding 17 33638056 protein_coding 7 72077830 protein_coding 17 55749984 protein_coding 15 78775138 protein_coding 2 122636986 protein_coding 16 23520291 protein_coding 6 86628164 protein_coding 14 70077203 protein_coding X 106143204 protein_coding 1 143640664 protein_coding 11 118392751 protein_coding 18 46165302 protein_coding 6 113596761 protein_coding 2 84734058 protein_coding 14 69241848 protein_coding 11 4257557 protein_coding 13 88821472 protein_coding 11 3494375 protein_coding 15 74762056 protein_coding 3 65528410

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 11 114982274 protein_coding 13 55464267 protein_coding 19 53529109 protein_coding 5 92346638 protein_coding 2 61802930 protein_coding 11 83525778 protein_coding X 169685199 protein_coding 16 55811375 protein_coding 9 124021972 protein_coding 10 86841198 protein_coding 17 52602709 protein_coding 19 34241090 protein_coding 9 36890982 protein_coding 15 91673175 unprocessed_pseudogene 17 34342933 protein_coding 8 68356781 protein_coding 3 59207892 protein_coding 8 65617900 protein_coding 10 96617006 protein_coding 17 34282744 protein_coding 4 136895917 protein_coding 4 136889804 protein_coding 7 30421732 protein_coding 7 30355489 protein_coding 2 148395344 protein_coding 17 56119678 protein_coding 19 46312087 protein_coding 12 12936093 protein_coding 10 61297833 protein_coding 3 37639947 protein_coding 19 3958645 protein_coding 17 34187553 protein_coding 4 134396320 protein_coding 15 38291463 protein_coding 4 133553376 protein_coding 10 67535475 protein_coding 7 142079490 protein_coding 3 136053363 protein_coding 11 98927818 protein_coding 18 60474193 protein_coding 13 46418434 protein_coding 1 171632403 protein_coding 11 75513540 protein_coding 11 97989578 protein_coding 9 109847379 protein_coding 2 155381059 protein_coding 1 170917576 protein_coding 10 4266380 protein_coding 7 44501699 protein_coding 11 74383356

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 8 10984681 protein_coding 4 63344560 protein_coding 11 121701544 protein_coding 6 48764464 protein_coding 4 70427065 protein_coding 1 184727140 protein_coding 1 184013302 protein_coding 18 24653691 protein_coding 5 43233170 protein_coding 8 123653929 protein_coding 7 46711998 protein_coding 2 118528757 protein_coding 4 33245423 protein_coding 2 118111876 protein_coding 4 32238804 protein_coding 17 27655509 protein_coding 11 46735080 protein_coding X 167242696 protein_coding 11 106311341 protein_coding 10 3740364 protein_coding 19 4214238 protein_coding 1 96816270 protein_coding 4 129461581 protein_coding 11 6658521 protein_coding 4 138775735 protein_coding 13 16011851 protein_coding 9 71504347 protein_coding 12 104236245 protein_coding X 155573455 protein_coding 5 114923240 protein_coding 17 6659093 protein_coding 17 48232768 protein_coding 1 131744022 protein_coding 14 31139013 protein_coding 13 112987802 protein_coding 5 21884454 protein_coding 1 130865669 protein_coding 18 21550377 protein_coding 6 39136623 protein_coding 15 79346621 protein_coding 4 125118423 protein_coding 12 81721010 protein_coding 7 126584942 protein_coding 4 152274232 protein_coding 1 53806876 protein_coding 11 75164565 antisense 18 21651448 protein_coding 8 71597648 protein_coding 17 28858411 protein_coding 16 57353093

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 17 48316141 lincRNA 7 142491074 protein_coding 6 122952515 protein_coding 17 48149126 protein_coding 9 111054486 protein_coding 2 24186476 protein_coding 11 110176820 protein_coding 7 28376784 protein_coding 7 102476579 protein_coding 13 34126748 protein_coding 11 69396519 protein_coding 5 123863570 protein_coding 17 17876471 protein_coding 1 84036296 protein_coding 4 63214004 protein_coding 7 142325837 protein_coding 19 4984355 protein_coding 13 110352616 protein_coding 7 24462484 protein_coding 5 137821952 protein_coding 16 57036967 protein_coding 12 75308322 protein_coding 10 75550123 protein_coding 11 48861968 protein_coding 16 97943357 protein_coding 1 36264597 protein_coding 14 51255262 protein_coding 17 70844205 protein_coding 10 8204756 protein_coding 11 115116214 protein_coding 6 48701582 protein_coding 9 44511787 protein_coding 16 30307685 protein_coding 9 45079183 protein_coding X 109196756 protein_coding 4 88522025 protein_coding 11 48904656 protein_coding 6 122921848 protein_coding 14 45219717 protein_coding 3 45378398 protein_coding 7 16246743 protein_coding 9 41964720 protein_coding 15 76268089 protein_coding 6 90301219 protein_coding 1 88673125 protein_coding 5 74195286 protein_coding 8 70616155 protein_coding 11 78472330 protein_coding 10 75937723 protein_coding 5 37338499

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 14 47367751 protein_coding 2 127338639 protein_coding 9 66508459 protein_coding 9 7272514 protein_coding 8 124369049 protein_coding X 107088492 protein_coding 4 134003330 protein_coding 3 85660061 protein_coding 13 43195245 protein_coding 10 26229707 protein_coding 18 36725074 protein_coding 19 24898965 protein_coding 7 55768178 protein_coding 1 174424064 protein_coding 17 48264295 protein_coding 11 83746940 protein_coding 16 45224315 protein_coding 7 63886351 protein_coding 4 57908483 protein_coding 7 24743983 protein_coding 17 17887824 protein_coding 7 103826534 protein_coding 1 84992690 protein_coding 1 168119364 protein_coding 8 84974484 protein_coding 7 122288751 protein_coding 6 53287270 protein_coding 6 71322788 protein_coding 13 19749682 protein_coding 7 3486500 protein_coding 16 90386013 protein_coding 8 84661331 protein_coding 3 126596302 protein_coding 6 71373427 protein_coding 18 60376029 protein_coding 7 45721212 protein_coding 7 24777206 protein_coding 6 48684549 protein_coding 15 98663421 protein_coding 16 36450537 pseudogene 4 3806635 protein_coding 7 99267447 protein_coding 8 115682942 protein_coding 11 46810800 protein_coding 7 45648591 protein_coding 3 144729677 protein_coding 3 90668978 protein_coding 3 90692632 protein_coding 3 84666192 protein_coding 4 132564067

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding X 103957163 protein_coding 15 77747798 protein_coding 1 155096361 protein_coding 11 44617317 protein_coding 9 21526176 protein_coding 10 60181532 protein_coding 13 41763148 protein_coding 5 90903871 protein_coding 11 4236420 protein_coding 7 3711409 protein_coding 1 171018920 protein_coding 7 141015699 protein_coding 1 171051174 protein_coding 16 36156811 protein_coding 10 61197112 protein_coding 3 87376387 protein_coding 11 67321658 protein_coding 2 178345293 protein_coding 14 60963875 protein_coding 17 34305877 protein_coding 19 40928927 protein_coding 2 101638282 protein_coding 6 117168535 protein_coding 4 135686287 protein_coding 1 107511423 protein_coding 3 10204088 antisense 11 89064729 transcribed_processed_pseudogene 6 148354656 protein_coding 7 44052290 protein_coding 13 21513222 protein_coding 7 44225360 protein_coding 10 6885796 protein_coding 1 134182176 Mt_rRNA MT 70 snoRNA 19 25166085 protein_coding 1 173673675 protein_coding 5 137865827 protein_coding 5 137852147 protein_coding 5 88519809 protein_coding 19 34617049 protein_coding 15 101485130 protein_coding 15 82221743 protein_coding 15 78479256 protein_coding 3 9250602 protein_coding 10 117287797 protein_coding 10 117277331 protein_coding 10 37133375 protein_coding 19 8989284 protein_coding 8 122619471 protein_coding 11 58274799

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 11 32283511 protein_coding 9 45117782 protein_coding 5 111417362 protein_coding 7 4237754 protein_coding 4 56743413 protein_coding 14 44851235 protein_coding 16 36359382 protein_coding 16 18620502 antisense 14 47097679 protein_coding 14 44102654 unprocessed_pseudogene 14 44046985 protein_coding 14 43818765 protein_coding 11 83065112 processed_transcript X 169975043 protein_coding 6 99692679 protein_coding 11 32286965 protein_coding 17 48125605 protein_coding 17 34263209 protein_coding 1 54472994 protein_coding 7 103812524 protein_coding 8 119434124 protein_coding 7 45413695 protein_coding 8 94434356 protein_coding 9 59680144 protein_coding 7 25461707 protein_coding 7 3884242 protein_coding 7 3816781 protein_coding 2 172450313 protein_coding 2 172393794 protein_coding 2 160363703 protein_coding 3 15795145 protein_coding 13 80883384 lincRNA 10 43593397 protein_coding 10 4367075 protein_coding 16 16860671 TR_C_gene 6 41546730 IG_V_gene 6 68437440 IG_V_gene 6 68541644 IG_V_gene 6 68834846 IG_V_gene 6 68910411 IG_V_gene 6 68939602 IG_V_gene 6 69042972 IG_V_gene 6 69184826 IG_V_gene 6 69267888 IG_V_gene 6 69304834 IG_V_gene 6 69416893 IG_V_gene 6 69544359 IG_V_gene 6 69575975 IG_V_gene 6 70058632 IG_V_gene 6 70074024

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

IG_V_gene 6 70216858 IG_V_gene 6 70335841 IG_V_gene 6 70355852 IG_J_gene 6 70722916 IG_J_gene 6 70723223 IG_J_gene 6 70723548 IG_J_gene 6 70723886 IG_C_gene 6 70726435 IG_C_gene 12 113302965 IG_C_gene 12 113418558 IG_J_gene 12 113428514 IG_V_gene 12 113578504 IG_V_gene 12 113896408 IG_V_gene 12 114176438 IG_V_gene 12 114322327 IG_V_gene 12 114366521 IG_V_gene 12 114391712 IG_V_gene 12 114434788 IG_V_gene 12 114682632 IG_V_gene 12 115055223 TR_C_gene 14 54220521 IG_V_gene 16 19085017 IG_V_gene 16 19241207 protein_coding 4 129491190 protein_coding 11 83116849 protein_coding 11 79526560 protein_coding 3 15946870 protein_coding 7 3289179 protein_coding 7 3218784 protein_coding 11 58199556 protein_coding 11 49076587 protein_coding 11 49057194 protein_coding 11 48985327 protein_coding 15 71795795 protein_coding 1 182954788 polymorphic_pseudogene 6 129461591 transcribed_unprocessed_pseudogene 1 85266698 protein_coding 1 78658038 protein_coding X 101849385 protein_coding 16 36184212 processed_pseudogene 11 55123695 polymorphic_pseudogene 7 3731630 unprocessed_pseudogene 7 4274189 protein_coding 11 83275110 unprocessed_pseudogene 4 63350411 processed_pseudogene 11 58187739 processed_pseudogene X 93527573 processed_pseudogene 2 34964738 processed_pseudogene 2 23019131 processed_pseudogene 11 114932871

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

processed_pseudogene 11 75427753 antisense 8 41017468 processed_transcript 11 75461539 antisense 2 3752986 antisense 11 96291024 antisense 8 41053110 lincRNA 13 111867936 lincRNA 2 28095477 protein_coding 3 100993529 lincRNA 4 11122805 processed_transcript 11 107428276 antisense 1 38384949 antisense X 8042943 antisense 1 9982387 antisense X 169979047 protein_coding 5 99217426 processed_pseudogene 6 122566715 protein_coding 7 3836812 protein_coding 14 43922720 processed_transcript 6 122560044 antisense 1 85246851 antisense 17 43588340 antisense 12 40198656 protein_coding 10 60399726 processed_pseudogene 13 34006966 processed_pseudogene 10 99444044 protein_coding 6 134981718 antisense 14 64111200 protein_coding 1 191162584 protein_coding 9 105856078 protein_coding 15 77633946 lincRNA 19 5795690 processed_transcript 15 65857869 polymorphic_pseudogene 7 101552453 miRNA 18 60812076 antisense 9 122380575 IG_V_gene 6 68270485 IG_V_gene 12 115158403 IG_V_gene 6 67839793 IG_V_gene 12 114851190 protein_coding 7 47426328 IG_V_gene 12 114196439 IG_V_gene 12 115507545 IG_V_gene 12 115802648 IG_V_gene 12 113826646 IG_V_gene 12 113838526 IG_V_gene 6 68121046 IG_V_gene 6 70143593 IG_V_gene 6 68631963 IG_V_gene 6 69823355

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

protein_coding 6 120488939 IG_V_gene 12 115920279 IG_V_gene 6 70406469 IG_V_gene 6 68049983 IG_V_gene 6 70215400 IG_V_gene 12 113625506 protein_coding 3 15495751 protein_coding 7 63916857 IG_C_gene 12 113254830 protein_coding 13 12472632 IG_V_gene 12 115567149 IG_V_gene 12 114538495 IG_V_gene 12 113736111 IG_V_gene 12 113661769 IG_V_gene 6 70663275 IG_V_gene 6 70698449 IG_V_gene 12 114615850 IG_V_gene 12 113702124 IG_V_gene 12 114487136 IG_V_gene 12 113859149 IG_V_gene 12 115208095 IG_V_gene 12 113597446 IG_V_gene 6 70260409 IG_V_gene 6 69500254 IG_V_gene 12 114059845 IG_V_gene 12 114723772 protein_coding 3 15371653 IG_V_gene 12 113653291 IG_V_gene 12 114896238 IG_V_gene 12 114479005 protein_coding 10 5020917 IG_V_gene 12 116000028 protein_coding 15 79028450 IG_V_gene 12 115868773 IG_V_gene 6 67609713 IG_V_gene 6 69814631 IG_V_gene 12 115861867 IG_V_gene 6 67791046 IG_V_gene 12 113588267 IG_V_gene 12 114513330 IG_V_gene 6 68519012 IG_V_gene 6 70340876 IG_V_gene 6 67942074 IG_V_gene 6 70434952 processed_transcript 1 194976375 lincRNA 11 51949882 bidirectional_promoter_lncRNA 9 119887449 lincRNA 7 19298260 antisense 5 24696902 lincRNA 16 84703167

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

antisense 8 72137389 lincRNA 19 53441212 antisense 9 21405242 lincRNA 1 150159043 lincRNA 19 53460631 antisense 1 96871126 antisense 5 67427680 antisense 1 40076228 processed_pseudogene 16 22236921 protein_coding 10 59221953 processed_pseudogene 12 71846311 protein_coding 1 9960163 protein_coding 7 14331436 processed_pseudogene 9 104169199 lincRNA 1 182287990 lincRNA 1 132342023 processed_pseudogene 1 55066264 lincRNA 10 95746077 antisense 12 117234521 transcribed_unprocessed_pseudogene 15 75131377 TEC 2 15056713 IG_V_gene 12 115067560 IG_V_pseudogene 12 114812321 TEC 1 10197081 TEC 3 84873891 IG_V_pseudogene 12 114843651 TEC 1 156026223 TEC 1 40088511 TEC 3 69119742 TEC 1 95646774 IG_V_gene 12 114657353 IG_V_gene 12 114764450 TEC 1 156856217 TEC 1 164872833 TEC 1 87897540 TEC 1 30833548 TEC 1 59646200 TEC 14 61667220 IG_V_gene 12 114253617 TEC 4 44702800 processed_transcript 1 164863133 IG_C_gene 12 113406604 TEC 1 156583108 TEC 4 6378018 antisense 1 171909957 IG_V_gene 12 115294062 sense_intronic 3 101595810 antisense 5 121835195 lincRNA 16 19212660 TEC 16 19231333

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

sense_intronic 3 100624902 TEC 5 43265157 TEC 5 105879583 TEC 5 122482800 TEC 5 45770020 TEC 3 41002434 IG_C_gene 16 19065230 IG_V_pseudogene 12 116009659 IG_V_gene 6 68302427 lincRNA 6 70719074 IG_V_pseudogene 12 115963817 IG_C_gene 16 19061618 antisense 3 109000024 TEC 3 135650670 TEC 3 37488827 TEC 3 98121588 TEC 5 43784046 TEC 5 67427993 processed_pseudogene 6 128883852 TEC 6 145238667 TEC 6 136620632 lincRNA 6 113725223 processed_transcript 5 148953748 TEC 6 134084601 TEC 6 86663188 TEC 7 127993269 TEC 7 73458597 lincRNA 7 66078902 TEC 7 90185927 antisense 7 81860293 protein_coding 10 82866626 lincRNA 8 12461419 lincRNA 7 142591744 processed_transcript 8 25101216 TEC 8 91055264 antisense 8 94170748 protein_coding 8 70703457 lincRNA 9 42141993 TEC 9 13308214 TEC 9 44618253 lincRNA 10 43745809 lincRNA 10 84518045 protein_coding 10 51480632 protein_coding 10 51490956 lincRNA 10 112837752 lincRNA 12 81717830 transcribed_processed_pseudogene 13 15813548 TEC 13 41476526 lincRNA 13 80940411 unprocessed_pseudogene 14 51277602

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

lincRNA 14 44821886 sense_intronic 16 24186029 lincRNA 16 24085083 antisense 15 76266461 lincRNA 15 74929437 lincRNA 15 84571730 antisense 16 94721894 TEC 16 22540473 processed_pseudogene 17 48238211

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

from 'F1-Lupus vs F1-P Gene.end.(bp) 5870394 96443619 83190216 74845725 77565708 166585720 129491022 101232756 82939769 134095082 96301569 75949657 83649355 90624181 106353288 86669161 8661242 77166548 97115331 94953042 95076801 40248504 37538319 73778925 44980431 16318205 24736143 112929776 19629438 55532466 153151441 24902197 72009626 9530176 43544428 9684259 57483527 28780233 106749037 75100589 3694175 7568485 172993576 4480487 94874976 167729172 102366203 136145755

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

44532071 77970563 33585582 193273217 46147343 7982213 14645056 3669259 44710487 63417037 129876672 88207032 25409494 80260371 171953170 171801184 9487771 43803132 134229625 131024974 24477377 164443887 36171259 51149111 98053462 15082456 165072948 164955850 164857711 98546031 69413675 55423183 84525535 142494867 70352031 83593087 83664683 54566489 98455373 19015657 44148853 103419377 89621253 99267489 21999903 24927484 23869843 87937042 60372684 117687352

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111508645 23770970 31935634 46389515 4948064 46407982 134079120 8016835 24662789 105989964 82446332 73329596 76027782 69109960 91549808 55492647 79156301 112868228 30766976 41487362 34653486 110400844 31436078 60388197 76507765 78308043 80023139 66152948 70979838 103056573 55784095 39760938 61990374 56694539 80398279 98004695 11066157 23988852 26371841 4213997 76511953 75159126 48874496 19772753 44333196 33819934 85803113 95721051 36726804 98778150

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

101274795 29100727 113100981 124888221 23645277 43612201 45563169 46032369 31855792 73950196 79090378 57228136 35649367 35202007 66465550 60812646 20390944 10738974 11266241 11081102 10859362 34166053 3929761 5707101 39642673 58455909 59296012 120960868 46312090 150570638 121794276 140774236 139992562 121283744 31563981 109032228 116461178 123968692 75395935 5373032 10009136 60915832 60773359 45503282 40500854 40125231 53785224 36782818 74386062 74161246

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

71653200 84935134 144004161 140183764 134151540 152836991 164458355 195176716 191218039 14332057 11693193 32388252 57124003 58195532 28084885 35307892 62694109 26516663 25628030 24351494 69404533 119760431 119354381 131086765 117343001 133562885 128162547 129371139 130050399 172474331 31122577 50443614 57575910 102782718 101287939 93526287 116129688 114220718 131224356 83841767 129822587 129332720 87855722 95509362 122530191 121735048 145934356 11174379 11714752 19922605

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

48086447 43454628 43483734 102607259 117133963 117116101 129085886 133001910 43843986 43912375 36398139 37336894 32157842 100899102 91148432 90893115 93276231 92043883 123784330 120711927 87388935 99726392 108666925 121365775 123289870 123275265 123143999 129275436 129507165 129678973 130306428 131247362 135383173 136661928 142964452 19296160 18890459 3915503 43418358 43660161 49636849 88491572 30880342 29153961 126414889 123500449 128118491 110863239 160498070 73495933

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

73896105 3748984 3878555 10039072 57477585 94366214 72153142 120165306 120052793 104144511 104631327 7873186 40964118 32757820 51240080 45009627 44987339 37255738 44142727 21749919 92297752 118486132 110423012 150108227 111042767 59657099 119984658 106096783 59566956 103718423 33645706 72306608 55853662 78803042 122641191 23614222 86629710 70082614 106160493 143654614 118402092 46212607 113600715 84738655 69285112 4272514 89323223 3504821 74763620 65555518

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

114989922 55473154 53542431 92348889 61814114 83530518 170005736 55838899 124031689 87008025 52979194 34255336 37147407 91816120 34344643 68735146 59210882 66471637 96622809 34287827 136898803 136893065 30428746 30362772 148396767 56122001 46327156 12941914 61304680 37644598 3972103 34197225 134427413 38300706 133556536 67542188 142095843 136326066 98974942 60501983 46431095 171653035 75526582 97996181 109849617 155389850 170927583 4359470 44524656 74610915

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

11008458 63348163 121716306 48770851 70534995 184732619 184075636 24701556 43289724 123663884 46715700 118549687 33290163 118127133 32586108 27711482 46779578 167264329 106314762 3967303 4223490 96872171 129488498 6677475 138782046 16031621 71592360 104241939 155623814 114937915 6738044 48246924 131771504 31168641 112990777 22344702 130880791 21654718 39206789 79359076 125127840 81781175 126589112 152285337 54195168 75169519 21656105 71607936 28890309 57573126

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

48327024 142506771 122969875 48167275 111057519 24193568 110251776 28380253 102481679 34130466 69398234 123865499 17883940 84364180 63334991 142373753 4989971 110357199 24475968 137836281 57071372 75401456 75560330 48871683 97962622 36274679 51256112 70853546 8518825 115133992 48708225 44561877 30310779 45108534 109200439 88522774 48992226 122934619 45282725 45435623 16259540 42124297 76292572 90305449 88702221 74199481 70621483 78497754 75940672 37425055

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

47386160 127357651 66514593 7283331 124439658 107104974 134018841 85817291 43304172 26272172 36726736 24901309 55778925 174434747 48275360 83752642 45257670 63938915 57916297 24760311 17893952 103828096 85270566 168432270 84978718 122634402 53700376 71337494 19824257 3502624 90499553 84662852 126846326 71379173 60392627 45729492 24784657 48692060 98677461 36455392 3808751 99337137 115707794 46844332 45666394 144760977 90670035 90695721 84704575 132582683

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

103981284 77757003 155099636 45008091 21545333 60219260 41847684 90905938 4241026 3720391 171029761 141017924 171064935 36161953 61273438 87402934 67371586 178407685 61046490 34316199 40994535 101649501 117181367 135708181 107535478 10208576 89069098 148355598 44056712 21531120 44229618 7052478 134190181 1024 25166216 173698395 137871815 137858106 88527891 34640743 101491512 82224369 78495271 9285333 117292868 117282321 37138920 9076919 122622739 58294289

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

32284465 45130070 111457033 4243463 56744925 44859375 36367748 18629954 47116161 44103534 44047450 43875517 83070678 169978917 99695066 32287784 48146268 34269418 54557684 103813996 119446256 45417179 94527272 59718874 25477603 3898120 3825687 172458596 172433757 160367065 15848528 80896042 43709668 4388108 16863985 41548352 68437925 68542422 68835307 68910973 68940067 69043505 69185397 69268443 69305405 69417455 69544907 69576500 70059199 70074603

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

70217421 70336507 70356445 70722958 70723260 70723585 70723927 70726966 113307933 113422730 113428567 113578990 113896946 114176867 114322801 114366954 114392169 114435244 114683065 115055656 54224206 19085500 19241690 129491956 83122670 79530609 16006437 3331099 3249740 58207591 49096974 49064206 48994172 72034227 182976044 129472779 85285491 78671512 102092055 36188111 55123937 3739889 4282645 83286726 63353846 58189012 93530309 34964904 23019667 114933271

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

75428152 41024216 75466676 3755177 96306910 41064706 111874730 28127731 101029556 11126998 107435686 38393974 8074619 9992366 169985232 99729065 122567474 3845051 43923559 122570849 85255465 43592442 40201105 60403559 34008331 99445819 134986836 64114641 191164817 105960643 77643286 5802672 65858356 101560865 60812163 122398801 68271267 115158835 67840266 114851660 47452139 114196875 115508031 115803080 113827129 113839010 68121827 70144166 68632442 69823943

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

120493807 115920712 70406992 68050456 70215957 113625956 15575065 63920539 113260236 12520438 115567591 114538965 113736630 113662293 70663895 70699067 114616318 113702578 114487569 113859670 115208591 113597977 70260955 69500786 114060321 114724205 15426520 113653724 114896671 114479451 5551482 116000461 79030504 115869227 67610508 69815154 115862355 67791511 113588702 114513807 68519477 70341453 67942540 70435476 195037904 52269514 119894863 19300770 24704690 84715245

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

72140820 53464796 21411720 150164948 53462723 96907796 67437990 40085851 22237315 59226434 71847291 9967932 14333557 104169811 182303325 132349626 55067069 95797236 117337022 75135128 15059473 115068002 114812745 10198802 84877776 114844083 156030007 40091581 69122724 95648508 114657786 114764883 156858859 164876353 87900532 30836431 59648071 61670131 114254051 44705110 164936775 113416324 156588248 6378292 171919356 115294504 101597130 121835828 19236776 19234802

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

100627022 43266368 105881844 122484999 45772180 41006089 19065681 116010093 68303158 70740554 115964250 19062071 109002094 135654566 37494792 98124650 43786117 67430403 128884543 145241227 136623006 113726151 148970122 134087464 86665551 127996598 73460633 66079473 90188198 81862527 82867930 12466964 142620804 25109986 91056557 94173412 70717650 42146506 13312446 44621018 43765836 84523270 51486703 51496611 112845385 81720052 16023423 41477900 80948597 51277709

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

44834142 24263159 24090089 76269839 74936316 84577117 94753438 22543886 48240641

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

F1-Prediseased Female Mice' (|FC|1.5, FDR<0.05) Gene.description Kruppel-like factor 6 [Source:MGI Symbol;Acc:MGI:1346318] integrin beta 2-like [Source:MGI Symbol;Acc:MGI:1277979] schlafen 4 [Source:MGI Symbol;Acc:MGI:1329010] binding protein [Source:MGI Symbol;Acc:MGI:109150] integrin beta 2 [Source:MGI Symbol;Acc:MGI:96611] EGF-like-domain, multiple 6 [Source:MGI Symbol;Acc:MGI:1858599] testis-specific serine kinase 3 [Source:MGI Symbol;Acc:MGI:1929914] GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein [Source:MGI Symbol;Acc:MGI:1860 sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain [Source:MGI Symbol;Acc CD52 antigen [Source:MGI Symbol;Acc:MGI:1346088] homeobox B6 [Source:MGI Symbol;Acc:MGI:96187] pre-B lymphocyte gene 3 [Source:MGI Symbol;Acc:MGI:98938] chemokine (C-C motif) ligand 3 [Source:MGI Symbol;Acc:MGI:98260] S100 calcium binding protein A6 (calcyclin) [Source:MGI Symbol;Acc:MGI:1339467] sodium channel, voltage-gated, type IV, alpha [Source:MGI Symbol;Acc:MGI:98250] MAX dimerization protein 1 [Source:MGI Symbol;Acc:MGI:96908] ephrin B2 [Source:MGI Symbol;Acc:MGI:105097] collagen, type XVIII, alpha 1 [Source:MGI Symbol;Acc:MGI:88451] T-box 21 [Source:MGI Symbol;Acc:MGI:1888984] collagen, type I, alpha 1 [Source:MGI Symbol;Acc:MGI:88467] [Source:MGI Symbol;Acc:MGI:96602] interferon-related developmental regulator 1 [Source:MGI Symbol;Acc:MGI:1316717] endothelial cell-specific adhesion molecule [Source:MGI Symbol;Acc:MGI:1916774] serine/arginine-rich protein specific kinase 3 [Source:MGI Symbol;Acc:MGI:1891338] CD3 antigen, gamma polypeptide [Source:MGI Symbol;Acc:MGI:88333] BCL2 binding component 3 [Source:MGI Symbol;Acc:MGI:2181667] ribosomal protein L3-like [Source:MGI Symbol;Acc:MGI:1913461] jagged 2 [Source:MGI Symbol;Acc:MGI:1098270] avian reticuloendotheliosis viral (v-rel) oncogene related B [Source:MGI Symbol;Acc:MGI:103289] Kruppel-like factor 4 (gut) [Source:MGI Symbol;Acc:MGI:1342287] hemopoietic cell kinase [Source:MGI Symbol;Acc:MGI:96052] CD79A antigen (immunoglobulin-associated alpha) [Source:MGI Symbol;Acc:MGI:101774] cytochrome P450, family 4, subfamily f, polypeptide 18 [Source:MGI Symbol;Acc:MGI:1919304] interleukin 7 receptor [Source:MGI Symbol;Acc:MGI:96562] CD33 antigen [Source:MGI Symbol;Acc:MGI:99440] ATP-binding cassette, sub-family A (ABC1), member 13 [Source:MGI Symbol;Acc:MGI:2388707] adhesion G protein-coupled receptor E1 [Source:MGI Symbol;Acc:MGI:106912] mitogen-activated protein kinase 13 [Source:MGI Symbol;Acc:MGI:1346864] interleukin 5 receptor, alpha [Source:MGI Symbol;Acc:MGI:96558] heme oxygenase 1 [Source:MGI Symbol;Acc:MGI:96163] Fc receptor, IgE, low affinity II, alpha polypeptide [Source:MGI Symbol;Acc:MGI:95497] matrix metallopeptidase 8 [Source:MGI Symbol;Acc:MGI:1202395] SPO11 meiotic protein covalently bound to DSB [Source:MGI Symbol;Acc:MGI:1349669] EPS8-like 1 [Source:MGI Symbol;Acc:MGI:1914675] TEK receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:98664] RIKEN cDNA A530013C23 gene [Source:MGI Symbol;Acc:MGI:3041178] solute carrier family 4 (anion exchanger), member 1 [Source:MGI Symbol;Acc:MGI:109393] inhibitor of DNA binding 3 [Source:MGI Symbol;Acc:MGI:96398]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

Spi-B transcription factor (Spi-1/PU.1 related) [Source:MGI Symbol;Acc:MGI:892986] transient receptor potential cation channel, subfamily M, member 2 [Source:MGI Symbol;Acc:MGI:1351901] testis expressed gene 15 [Source:MGI Symbol;Acc:MGI:1934816] G0/G1 switch gene 2 [Source:MGI Symbol;Acc:MGI:1316737] a disintegrin and metallopeptidase domain 19 (meltrin beta) [Source:MGI Symbol;Acc:MGI:105377] STEAP family member 4 [Source:MGI Symbol;Acc:MGI:1923560] angiomotin-like 1 [Source:MGI Symbol;Acc:MGI:1922973] mast cell expressed membrane protein 1 [Source:MGI Symbol;Acc:MGI:1916439] paired box 5 [Source:MGI Symbol;Acc:MGI:97489] B lymphoid kinase [Source:MGI Symbol;Acc:MGI:88169] killer cell lectin-like receptor, subfamily A, member 17 [Source:MGI Symbol;Acc:MGI:2180674] GATA binding protein 2 [Source:MGI Symbol;Acc:MGI:95662] neural proliferation, differentiation and control 1 [Source:MGI Symbol;Acc:MGI:1099802] actinin, alpha 1 [Source:MGI Symbol;Acc:MGI:2137706] SLAM family member 6 [Source:MGI Symbol;Acc:MGI:1353620] signaling lymphocytic activation molecule family member 1 [Source:MGI Symbol;Acc:MGI:1351314] cytochrome b-245, beta polypeptide [Source:MGI Symbol;Acc:MGI:88574] CD83 antigen [Source:MGI Symbol;Acc:MGI:1328316] neutrophil cytosolic factor 1 [Source:MGI Symbol;Acc:MGI:97283] interleukin 10 [Source:MGI Symbol;Acc:MGI:96537] cytidine monophospho-N-acetylneuraminic acid hydroxylase [Source:MGI Symbol;Acc:MGI:103227] syndecan 4 [Source:MGI Symbol;Acc:MGI:1349164] interleukin 13 receptor, alpha 1 [Source:MGI Symbol;Acc:MGI:105052] Rho family GTPase 3 [Source:MGI Symbol;Acc:MGI:1921444] SH3 and cysteine rich domain 2 [Source:MGI Symbol;Acc:MGI:2144518] ADP-ribosylation factor-like 5B [Source:MGI Symbol;Acc:MGI:1923119] CD40 antigen [Source:MGI Symbol;Acc:MGI:88336] matrix metallopeptidase 9 [Source:MGI Symbol;Acc:MGI:97011] phospholipid transfer protein [Source:MGI Symbol;Acc:MGI:103151] IKAROS family zinc finger 3 [Source:MGI Symbol;Acc:MGI:1342542] KDM1 lysine (K)-specific demethylase 6B [Source:MGI Symbol;Acc:MGI:2448492] secreted acidic cysteine rich glycoprotein [Source:MGI Symbol;Acc:MGI:98373] LIM homeobox protein 1 [Source:MGI Symbol;Acc:MGI:99783] lymphocyte specific 1 [Source:MGI Symbol;Acc:MGI:96832] arachidonate 15-lipoxygenase [Source:MGI Symbol;Acc:MGI:87997] chemokine (C-C motif) ligand 6 [Source:MGI Symbol;Acc:MGI:98263] chemokine (C-C motif) ligand 4 [Source:MGI Symbol;Acc:MGI:98261] secernin 1 [Source:MGI Symbol;Acc:MGI:1917188] growth factor receptor bound protein 7 [Source:MGI Symbol;Acc:MGI:102683] tumor necrosis factor, alpha-induced protein 3 [Source:MGI Symbol;Acc:MGI:1196377] crystallin beta-gamma domain containing 1 [Source:MGI Symbol;Acc:MGI:109544] solute carrier family 6 (neurotransmitter transporter), member 15 [Source:MGI Symbol;Acc:MGI:2143484] solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 [Source:MGI Symbo dual specificity phosphatase 6 [Source:MGI Symbol;Acc:MGI:1914853] serum/glucocorticoid regulated kinase 1 [Source:MGI Symbol;Acc:MGI:1340062] arginase, liver [Source:MGI Symbol;Acc:MGI:88070] vanin 3 [Source:MGI Symbol;Acc:MGI:1347055] insulin-like growth factor 1 [Source:MGI Symbol;Acc:MGI:96432] V-set immunoregulatory receptor [Source:MGI Symbol;Acc:MGI:1921298] carboxypeptidase M [Source:MGI Symbol;Acc:MGI:1917824]

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pleckstrin homology like domain, family A, member 1 [Source:MGI Symbol;Acc:MGI:1096880] reticuloendotheliosis oncogene [Source:MGI Symbol;Acc:MGI:97897] cytoplasmic polyadenylation element binding protein 4 [Source:MGI Symbol;Acc:MGI:1914829] IL2 inducible T cell kinase [Source:MGI Symbol;Acc:MGI:96621] neurofilament, heavy polypeptide [Source:MGI Symbol;Acc:MGI:97309] family with sequence similarity 71, member B [Source:MGI Symbol;Acc:MGI:3650836] B cell translocation gene 2, anti-proliferative [Source:MGI Symbol;Acc:MGI:108384] apolipoprotein B [Source:MGI Symbol;Acc:MGI:88052] Kruppel-like factor 11 [Source:MGI Symbol;Acc:MGI:2653368] angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 [Source:MGI Symbol;Acc:MGI:87874] transmembrane protein 132E [Source:MGI Symbol;Acc:MGI:2685490] aspartoacylase [Source:MGI Symbol;Acc:MGI:87914] refilin B [Source:MGI Symbol;Acc:MGI:1923816] period circadian clock 1 [Source:MGI Symbol;Acc:MGI:1098283] thyroid stimulating hormone receptor [Source:MGI Symbol;Acc:MGI:98849] nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [Source:MGI Symbol;Acc:MGI: arginase type II [Source:MGI Symbol;Acc:MGI:1330806] G protein-coupled receptor 132 [Source:MGI Symbol;Acc:MGI:1890220] interferon regulatory factor 4 [Source:MGI Symbol;Acc:MGI:1096873] neural precursor cell expressed, developmentally down-regulated gene 9 [Source:MGI Symbol;Acc:MGI:97302] PX domain containing 1 [Source:MGI Symbol;Acc:MGI:1914145] polo like kinase 2 [Source:MGI Symbol;Acc:MGI:1099790] SH3-domain binding protein 5 (BTK-associated) [Source:MGI Symbol;Acc:MGI:1344391] APC membrane recruitment 2 [Source:MGI Symbol;Acc:MGI:1919375] TSC22 domain family, member 1 [Source:MGI Symbol;Acc:MGI:109127] tumor necrosis factor (ligand) superfamily, member 11 [Source:MGI Symbol;Acc:MGI:1100089] olfactomedin 4 [Source:MGI Symbol;Acc:MGI:2685142] cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) [Source:MGI Symbol;Acc:MGI:87886] glial cell line derived neurotrophic factor family receptor alpha 2 [Source:MGI Symbol;Acc:MGI:1195462] aconitate decarboxylase 1 [Source:MGI Symbol;Acc:MGI:103206] adenylate cyclase 4 [Source:MGI Symbol;Acc:MGI:99674] dendrocyte expressed seven transmembrane protein [Source:MGI Symbol;Acc:MGI:1923016] myelocytomatosis oncogene [Source:MGI Symbol;Acc:MGI:97250] hyaluronan synthase 2 [Source:MGI Symbol;Acc:MGI:107821] calcium channel, voltage-dependent, alpha 1I subunit [Source:MGI Symbol;Acc:MGI:2178051] collagen, type II, alpha 1 [Source:MGI Symbol;Acc:MGI:88452] LPS-induced TN factor [Source:MGI Symbol;Acc:MGI:1929512] B cell leukemia/lymphoma 6 [Source:MGI Symbol;Acc:MGI:107187] claudin 1 [Source:MGI Symbol;Acc:MGI:1276109] CREB binding protein [Source:MGI Symbol;Acc:MGI:1098280] diacylglycerol O-acyltransferase 1 [Source:MGI Symbol;Acc:MGI:1333825] lymphocyte antigen 6 complex, locus G [Source:MGI Symbol;Acc:MGI:109440] resistin like gamma [Source:MGI Symbol;Acc:MGI:2667763] UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 [Source:MGI Symbol;Acc:MGI:2137302] SID1 transmembrane family, member 1 [Source:MGI Symbol;Acc:MGI:2443155] mucin 13, epithelial transmembrane [Source:MGI Symbol;Acc:MGI:103190] a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 [Source:MGI Sym E26 avian leukemia oncogene 2, 3' domain [Source:MGI Symbol;Acc:MGI:95456] immunoglobulin-like domain containing receptor 1 [Source:MGI Symbol;Acc:MGI:2146574] wingless-type MMTV integration site family, member 10B [Source:MGI Symbol;Acc:MGI:108061]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

nuclear receptor subfamily 4, group A, member 1 [Source:MGI Symbol;Acc:MGI:1352454] cyclin-dependent kinase inhibitor 1A (P21) [Source:MGI Symbol;Acc:MGI:104556] granzyme A [Source:MGI Symbol;Acc:MGI:109266] CD4 antigen [Source:MGI Symbol;Acc:MGI:88335] matrix metallopeptidase 25 [Source:MGI Symbol;Acc:MGI:2443938] phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) [Source:MGI Symbol;Acc:MGI:13 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon [Source:MGI Symbol;Acc:MGI vascular endothelial growth factor A [Source:MGI Symbol;Acc:MGI:103178] salt inducible kinase 1 [Source:MGI Symbol;Acc:MGI:104754] xanthine dehydrogenase [Source:MGI Symbol;Acc:MGI:98973] glutaminyl-peptide cyclotransferase (glutaminyl cyclase) [Source:MGI Symbol;Acc:MGI:1917786] complement component 3 [Source:MGI Symbol;Acc:MGI:88227] marginal zone B and B1 cell-specific protein 1 [Source:MGI Symbol;Acc:MGI:1917066] tumor necrosis factor [Source:MGI Symbol;Acc:MGI:104798] phorbol-12-myristate-13-acetate-induced protein 1 [Source:MGI Symbol;Acc:MGI:1930146] CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) [Source:M annexin A1 [Source:MGI Symbol;Acc:MGI:96819] CD5 antigen [Source:MGI Symbol;Acc:MGI:88340] membrane-spanning 4-domains, subfamily A, member 1 [Source:MGI Symbol;Acc:MGI:88321] membrane-spanning 4-domains, subfamily A, member 8A [Source:MGI Symbol;Acc:MGI:1927657] solute carrier family 15, member 3 [Source:MGI Symbol;Acc:MGI:1929691] ankyrin repeat domain 22 [Source:MGI Symbol;Acc:MGI:1277101] aldehyde dehydrogenase 3 family, member B1 [Source:MGI Symbol;Acc:MGI:1914939] potassium channel, subfamily K, member 7 [Source:MGI Symbol;Acc:MGI:1341841] macrophage scavenger receptor 1 [Source:MGI Symbol;Acc:MGI:98257] glial cell line derived neurotrophic factor family receptor alpha 1 [Source:MGI Symbol;Acc:MGI:1100842] solute carrier family 18 (vesicular monoamine), member 2 [Source:MGI Symbol;Acc:MGI:106677] solute carrier family 16 (monocarboxylic acid transporters), member 3 [Source:MGI Symbol;Acc:MGI:1933438] nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 [Source:MGI Symbol;Acc:MGI:109 aminolevulinic acid synthase 2, erythroid [Source:MGI Symbol;Acc:MGI:87990] junctophilin 3 [Source:MGI Symbol;Acc:MGI:1891497] peptidyl arginine deiminase, type IV [Source:MGI Symbol;Acc:MGI:1338898] a disintegrin and metallopeptidase domain 8 [Source:MGI Symbol;Acc:MGI:107825] FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived) [Source:MGI Symbol;Acc:MGI:24 podocalyxin-like [Source:MGI Symbol;Acc:MGI:1351317] 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 [Source:MGI Symbol;Acc:MGI:2687284] arachidonate 5-lipoxygenase [Source:MGI Symbol;Acc:MGI:87999] chemokine (C-C motif) receptor 1 [Source:MGI Symbol;Acc:MGI:104618] SMAD family member 7 [Source:MGI Symbol;Acc:MGI:1100518] caspase 12 [Source:MGI Symbol;Acc:MGI:1312922] protein phosphatase 1, regulatory subunit 42 [Source:MGI Symbol;Acc:MGI:1921138] cytotoxic T-lymphocyte-associated protein 4 [Source:MGI Symbol;Acc:MGI:88556] CD28 antigen [Source:MGI Symbol;Acc:MGI:88327] collagen, type V, alpha 2 [Source:MGI Symbol;Acc:MGI:88458] interleukin 18 receptor 1 [Source:MGI Symbol;Acc:MGI:105383] interleukin 1 receptor, type II [Source:MGI Symbol;Acc:MGI:96546] serine/threonine kinase 17b (apoptosis-inducing) [Source:MGI Symbol;Acc:MGI:2138162] zeta-chain (TCR) associated protein kinase [Source:MGI Symbol;Acc:MGI:99613] solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 [Source:MGI Symbol;Acc:M chemokine (C-X-C motif) receptor 2 [Source:MGI Symbol;Acc:MGI:105303]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

fibronectin 1 [Source:MGI Symbol;Acc:MGI:95566] solute carrier family 16 (monocarboxylic acid transporters), member 14 [Source:MGI Symbol;Acc:MGI:1919031] regulator of G-protein signaling 2 [Source:MGI Symbol;Acc:MGI:1098271] complement component factor h [Source:MGI Symbol;Acc:MGI:88385] chitinase 1 (chitotriosidase) [Source:MGI Symbol;Acc:MGI:1919134] neutrophil cytosolic factor 2 [Source:MGI Symbol;Acc:MGI:97284] ATPase, Na+/K+ transporting, beta 1 polypeptide [Source:MGI Symbol;Acc:MGI:88108] [Source:MGI Symbol;Acc:MGI:88489] activating transcription factor 3 [Source:MGI Symbol;Acc:MGI:109384] mannose receptor, C type 1 [Source:MGI Symbol;Acc:MGI:97142] interleukin 2 receptor, alpha chain [Source:MGI Symbol;Acc:MGI:96549] lipocalin 2 [Source:MGI Symbol;Acc:MGI:96757] nuclear receptor subfamily 4, group A, member 2 [Source:MGI Symbol;Acc:MGI:1352456] cytohesin 1 interacting protein [Source:MGI Symbol;Acc:MGI:2183535] ficolin B [Source:MGI Symbol;Acc:MGI:1341158] [Source:MGI Symbol;Acc:MGI:95851] grancalcin [Source:MGI Symbol;Acc:MGI:1918521] notch 1 [Source:MGI Symbol;Acc:MGI:97363] ficolin A [Source:MGI Symbol;Acc:MGI:1340905] interleukin 1 receptor antagonist [Source:MGI Symbol;Acc:MGI:96547] dehydrogenase/reductase (SDR family) member 9 [Source:MGI Symbol;Acc:MGI:2442798] leukocyte tyrosine kinase [Source:MGI Symbol;Acc:MGI:96840] ChaC, cation transport regulator 1 [Source:MGI Symbol;Acc:MGI:1916315] sialic acid binding Ig-like lectin 1, sialoadhesin [Source:MGI Symbol;Acc:MGI:99668] RAS guanyl releasing protein 1 [Source:MGI Symbol;Acc:MGI:1314635] bone morphogenetic protein 2 [Source:MGI Symbol;Acc:MGI:88177] BCL2-like 11 (apoptosis facilitator) [Source:MGI Symbol;Acc:MGI:1197519] interleukin 1 beta [Source:MGI Symbol;Acc:MGI:96543] transglutaminase 3, E polypeptide [Source:MGI Symbol;Acc:MGI:98732] family with sequence similarity 209 [Source:MGI Symbol;Acc:MGI:1923676] SKI-like [Source:MGI Symbol;Acc:MGI:106203] solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 [Source:MGI Symbol;Acc:MGI:13 WW domain containing transcription regulator 1 [Source:MGI Symbol;Acc:MGI:1917649] thyroid stimulating hormone, beta subunit [Source:MGI Symbol;Acc:MGI:98848] CD2 antigen [Source:MGI Symbol;Acc:MGI:88320] S100 calcium binding protein A11 [Source:MGI Symbol;Acc:MGI:1338798] vascular cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:98926] collagen, type XI, alpha 1 [Source:MGI Symbol;Acc:MGI:88446] lymphoid enhancer binding factor 1 [Source:MGI Symbol;Acc:MGI:96770] toll-like receptor 2 [Source:MGI Symbol;Acc:MGI:1346060] retinal pigment epithelium derived homolog [Source:MGI Symbol;Acc:MGI:1097709] [Source:MGI Symbol;Acc:MGI:106645] SH2 domain containing 2A [Source:MGI Symbol;Acc:MGI:1351596] cathepsin K [Source:MGI Symbol;Acc:MGI:107823] breast cancer anti-estrogen resistance 3 [Source:MGI Symbol;Acc:MGI:1352501] coagulation factor III [Source:MGI Symbol;Acc:MGI:88381] B cell leukemia/lymphoma 10 [Source:MGI Symbol;Acc:MGI:1337994] transformation related protein 53 inducible nuclear protein 1 [Source:MGI Symbol;Acc:MGI:1926609] GTP binding protein (gene overexpressed in skeletal muscle) [Source:MGI Symbol;Acc:MGI:99844] ATPase, H+ transporting, lysosomal V0 subunit D2 [Source:MGI Symbol;Acc:MGI:1924415]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

nuclear receptor subfamily 4, group A, member 3 [Source:MGI Symbol;Acc:MGI:1352457] CD72 antigen [Source:MGI Symbol;Acc:MGI:88345] suppression inducing transmembrane adaptor 1 [Source:MGI Symbol;Acc:MGI:1889342] phosphodiesterase 4B, cAMP specific [Source:MGI Symbol;Acc:MGI:99557] polo like kinase 3 [Source:MGI Symbol;Acc:MGI:109604] patched 2 [Source:MGI Symbol;Acc:MGI:1095405] ring finger protein 19B [Source:MGI Symbol;Acc:MGI:1922484] FGR proto-oncogene, Src family tyrosine kinase [Source:MGI Symbol;Acc:MGI:95527] bone marrow stromal cell antigen 1 [Source:MGI Symbol;Acc:MGI:105370] CD38 antigen [Source:MGI Symbol;Acc:MGI:107474] sortilin-related VPS10 domain containing receptor 2 [Source:MGI Symbol;Acc:MGI:1932289] EvC ciliary complex subunit 1 [Source:MGI Symbol;Acc:MGI:1890596] fos-like antigen 2 [Source:MGI Symbol;Acc:MGI:102858] glycerol-3-phosphate acyltransferase 3 [Source:MGI Symbol;Acc:MGI:3603816] amphiregulin [Source:MGI Symbol;Acc:MGI:88068] chemokine (C-X-C motif) ligand 1 [Source:MGI Symbol;Acc:MGI:108068] cyclin G2 [Source:MGI Symbol;Acc:MGI:1095734] cyclin-dependent kinase-like 2 (CDC2-related kinase) [Source:MGI Symbol;Acc:MGI:1858227] chemokine (C-C motif) receptor 9 [Source:MGI Symbol;Acc:MGI:1341902] deltex 1, E3 [Source:MGI Symbol;Acc:MGI:1352744] gastrokine 3 [Source:MGI Symbol;Acc:MGI:1916138] prokineticin 2 [Source:MGI Symbol;Acc:MGI:1354178] basic helix-loop-helix family, member e40 [Source:MGI Symbol;Acc:MGI:1097714] solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 [Source:MGI Symbol;Acc:MGI C-type lectin domain family 4, member e [Source:MGI Symbol;Acc:MGI:1861232] C-type lectin domain family 4, member d [Source:MGI Symbol;Acc:MGI:1298389] C-type lectin domain family 4, member a2 [Source:MGI Symbol;Acc:MGI:1349412] CD69 antigen [Source:MGI Symbol;Acc:MGI:88343] oxidized low density lipoprotein (lectin-like) receptor 1 [Source:MGI Symbol;Acc:MGI:1261434] killer cell lectin-like receptor subfamily C, member 1 [Source:MGI Symbol;Acc:MGI:1336161] killer cell lectin-like receptor subfamily A, member 13, pseudogene [Source:MGI Symbol;Acc:MGI:1321090] killer cell lectin-like receptor, subfamily A, member 2 [Source:MGI Symbol;Acc:MGI:101906] epithelial membrane protein 1 [Source:MGI Symbol;Acc:MGI:107941] phospholipase B domain containing 1 [Source:MGI Symbol;Acc:MGI:1914107] ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 [Source:MGI Symbol;Acc:MGI:106011] reticulon 2 (Z-band associated protein) [Source:MGI Symbol;Acc:MGI:107612] peptidoglycan recognition protein 1 [Source:MGI Symbol;Acc:MGI:1345092] leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 [Source:MGI Symbol;Acc:MGI sialic acid binding Ig-like lectin G [Source:MGI Symbol;Acc:MGI:2443630] sialic acid binding Ig-like lectin E [Source:MGI Symbol;Acc:MGI:1932475] developing brain homeobox 1 [Source:MGI Symbol;Acc:MGI:94867] RAB38, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:1919683] CD22 antigen [Source:MGI Symbol;Acc:MGI:88322] RAS guanyl releasing protein 4 [Source:MGI Symbol;Acc:MGI:2386851] CD19 antigen [Source:MGI Symbol;Acc:MGI:88319] zinc finger with KRAB and SCAN domains 2 [Source:MGI Symbol;Acc:MGI:2444060] integrin alpha M [Source:MGI Symbol;Acc:MGI:96607] lymphatic vessel endothelial hyaluronan receptor 1 [Source:MGI Symbol;Acc:MGI:2136348] adhesion G protein-coupled receptor G2 [Source:MGI Symbol;Acc:MGI:2446854] biglycan [Source:MGI Symbol;Acc:MGI:88158]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

L1 cell adhesion molecule [Source:MGI Symbol;Acc:MGI:96721] CD209a antigen [Source:MGI Symbol;Acc:MGI:2157942] CD209d antigen [Source:MGI Symbol;Acc:MGI:2157947] tumor necrosis factor (ligand) superfamily, member 13b [Source:MGI Symbol;Acc:MGI:1344376] scrapie responsive gene 1 [Source:MGI Symbol;Acc:MGI:1328308] solute carrier family 12, member 3 [Source:MGI Symbol;Acc:MGI:108114] tropomyosin 4 [Source:MGI Symbol;Acc:MGI:2449202] RIKEN cDNA 6430548M08 gene [Source:MGI Symbol;Acc:MGI:2443793] cysteine-rich secretory protein LCCL domain containing 2 [Source:MGI Symbol;Acc:MGI:1926142] cadherin 5 [Source:MGI Symbol;Acc:MGI:105057] Ras-related associated with diabetes [Source:MGI Symbol;Acc:MGI:1930943] baculoviral IAP repeat-containing 3 [Source:MGI Symbol;Acc:MGI:1197007] junctional cadherin complex regulator [Source:MGI Symbol;Acc:MGI:1918239] E26 avian leukemia oncogene 1, 5' domain [Source:MGI Symbol;Acc:MGI:95455] POU domain, class 2, associating factor 1 [Source:MGI Symbol;Acc:MGI:105086] CD3 antigen, epsilon polypeptide [Source:MGI Symbol;Acc:MGI:88332] CD3 antigen, delta polypeptide [Source:MGI Symbol;Acc:MGI:88331] solute carrier family 37 (glycerol-3-phosphate transporter), member 2 [Source:MGI Symbol;Acc:MGI:1929693] melanoma cell adhesion molecule [Source:MGI Symbol;Acc:MGI:1933966] low density lipoprotein receptor [Source:MGI Symbol;Acc:MGI:96765] phospholipid scramblase 2 [Source:MGI Symbol;Acc:MGI:1270860] eomesodermin [Source:MGI Symbol;Acc:MGI:1201683] neutrophilic granule protein [Source:MGI Symbol;Acc:MGI:105983] prostaglandin-endoperoxide synthase 2 [Source:MGI Symbol;Acc:MGI:97798] lactotransferrin [Source:MGI Symbol;Acc:MGI:96837] tribbles pseudokinase 1 [Source:MGI Symbol;Acc:MGI:2443397] cysteine-serine-rich nuclear protein 1 [Source:MGI Symbol;Acc:MGI:2387989] collagen, type VI, alpha 4 [Source:MGI Symbol;Acc:MGI:1915803] NLR family, pyrin domain containing 3 [Source:MGI Symbol;Acc:MGI:2653833] ankyrin repeat and BTB (POZ) domain containing 2 [Source:MGI Symbol;Acc:MGI:2139365] PML-RAR alpha-regulated adaptor molecule 1 [Source:MGI Symbol;Acc:MGI:3576625] multiple C2 domains, transmembrane 2 [Source:MGI Symbol;Acc:MGI:2685335] adhesion G protein-coupled receptor E4 [Source:MGI Symbol;Acc:MGI:1196464] caspase recruitment domain family, member 10 [Source:MGI Symbol;Acc:MGI:2146012] expressed sequence AA467197 [Source:MGI Symbol;Acc:MGI:3034182] receptor transporter protein 4 [Source:MGI Symbol;Acc:MGI:1915025] aspartic peptidase, retroviral-like 1 [Source:MGI Symbol;Acc:MGI:1915105] early growth response 3 [Source:MGI Symbol;Acc:MGI:1306780] toll-like receptor 13 [Source:MGI Symbol;Acc:MGI:3045213] UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 [Source:MGI Symbol;Acc:MGI:1349461] lectin, galactoside-binding, soluble, 3 binding protein [Source:MGI Symbol;Acc:MGI:99554] tripartite motif-containing 36 [Source:MGI Symbol;Acc:MGI:106264] Fancd2 opposite strand [Source:MGI Symbol;Acc:MGI:1918229] yippee like 4 [Source:MGI Symbol;Acc:MGI:3605071] solute carrier family 25, member 37 [Source:MGI Symbol;Acc:MGI:1914962] leukemia inhibitory factor [Source:MGI Symbol;Acc:MGI:96787] EGF-like repeats and discoidin I-like domains 3 [Source:MGI Symbol;Acc:MGI:1329025] inositol polyphosphate 5-phosphatase J [Source:MGI Symbol;Acc:MGI:2158663] lymphocyte antigen 6 complex, locus D [Source:MGI Symbol;Acc:MGI:96881] TCDD-inducible poly(ADP-ribose) polymerase [Source:MGI Symbol;Acc:MGI:2159210]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

CD300 molecule like family member d [Source:MGI Symbol;Acc:MGI:2442358] proline rich 7 (synaptic) [Source:MGI Symbol;Acc:MGI:3487246] dual specificity phosphatase 5 [Source:MGI Symbol;Acc:MGI:2685183] chemokine (C-X-C motif) ligand 10 [Source:MGI Symbol;Acc:MGI:1352450] T-box brain gene 1 [Source:MGI Symbol;Acc:MGI:107404] chemokine (C-C motif) ligand 5 [Source:MGI Symbol;Acc:MGI:98262] midline 1 [Source:MGI Symbol;Acc:MGI:1100537] nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta [Source:MGI Symbol;Acc:MGI:1 chemokine (C-C motif) receptor 3 [Source:MGI Symbol;Acc:MGI:104616] stabilin 2 [Source:MGI Symbol;Acc:MGI:2178743] potassium voltage-gated channel, subfamily H (eag-related), member 8 [Source:MGI Symbol;Acc:MGI:2445160] actin, alpha 2, smooth muscle, aorta [Source:MGI Symbol;Acc:MGI:87909] Pbx/knotted 1 homeobox 2 [Source:MGI Symbol;Acc:MGI:2445415] leucine-rich repeat kinase 2 [Source:MGI Symbol;Acc:MGI:1913975] histocompatibility 2, class II antigen E alpha, pseudogene [Source:MGI Symbol;Acc:MGI:95900] chondroitin sulfate N-acetylgalactosaminyltransferase 1 [Source:MGI Symbol;Acc:MGI:2442354] purinergic receptor P2Y, G-protein coupled 13 [Source:MGI Symbol;Acc:MGI:1921441] membrane-associated ring finger (C3HC4) 1 [Source:MGI Symbol;Acc:MGI:1920175] B cell translocation gene 1, anti-proliferative [Source:MGI Symbol;Acc:MGI:88215] histocompatibility 2, class II antigen A, alpha [Source:MGI Symbol;Acc:MGI:95895] complement component 1, q subcomponent, alpha polypeptide [Source:MGI Symbol;Acc:MGI:88223] complement component 1, q subcomponent, C chain [Source:MGI Symbol;Acc:MGI:88225] nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta [Source:MGI Symbol;Acc:MGI:3 leucine rich repeat and fibronectin type III domain containing 3 [Source:MGI Symbol;Acc:MGI:2442512] somatostatin receptor 4 [Source:MGI Symbol;Acc:MGI:105372] leucine-rich alpha-2-glycoprotein 1 [Source:MGI Symbol;Acc:MGI:1924155] pleckstrin and Sec7 domain containing [Source:MGI Symbol;Acc:MGI:1920978] v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived [Source:MGI Symbol;Acc:MGI:973 perforin 1 (pore forming protein) [Source:MGI Symbol;Acc:MGI:97551] sprouty RTK signaling antagonist 1 [Source:MGI Symbol;Acc:MGI:1345139] aldehyde dehydrogenase 3 family, member B3 [Source:MGI Symbol;Acc:MGI:1920708] transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) [Source:MGI Symbol;Acc:MGI:98483] platelet-activating factor acetylhydrolase 2 [Source:MGI Symbol;Acc:MGI:2140321] Kruppel-like factor 10 [Source:MGI Symbol;Acc:MGI:1101353] nuclear receptor subfamily 0, group B, member 2 [Source:MGI Symbol;Acc:MGI:1346344] early growth response 2 [Source:MGI Symbol;Acc:MGI:95296] dual specificity phosphatase 8 [Source:MGI Symbol;Acc:MGI:106626] B cell scaffold protein with ankyrin repeats 1 [Source:MGI Symbol;Acc:MGI:2442120] , alpha [Source:MGI Symbol;Acc:MGI:97856] small integral membrane protein 3 [Source:MGI Symbol;Acc:MGI:1917088] RNA binding motif protein 24 [Source:MGI Symbol;Acc:MGI:3610364] SLAM family member 7 [Source:MGI Symbol;Acc:MGI:1922595] scavenger receptor class F, member 1 [Source:MGI Symbol;Acc:MGI:2449455] ADP-ribosylation factor-like 5C [Source:MGI Symbol;Acc:MGI:3028577] cathelicidin antimicrobial peptide [Source:MGI Symbol;Acc:MGI:108443] transformation related protein 53 inducible nuclear protein 2 [Source:MGI Symbol;Acc:MGI:1915978] Fc receptor-like A [Source:MGI Symbol;Acc:MGI:2138647] A kinase (PRKA) anchor protein (gravin) 12 [Source:MGI Symbol;Acc:MGI:1932576] myosin binding protein C, fast-type [Source:MGI Symbol;Acc:MGI:1336170] RAP1 GTPase activating protein 2 [Source:MGI Symbol;Acc:MGI:3028623]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

insulin receptor substrate 2 [Source:MGI Symbol;Acc:MGI:109334] orosomucoid 1 [Source:MGI Symbol;Acc:MGI:97443] meteorin, glial cell differentiation regulator-like [Source:MGI Symbol;Acc:MGI:2384806] GTPase, IMAP family member 3 [Source:MGI Symbol;Acc:MGI:1932723] multiple EGF-like-domains 9 [Source:MGI Symbol;Acc:MGI:1918264] H2.0-like homeobox [Source:MGI Symbol;Acc:MGI:96109] dual specificity phosphatase 10 [Source:MGI Symbol;Acc:MGI:1927070] molybdenum sulfurase [Source:MGI Symbol;Acc:MGI:1915841] cytoplasmic polyadenylation element binding protein 2 [Source:MGI Symbol;Acc:MGI:2442640] ras homolog family member U [Source:MGI Symbol;Acc:MGI:1916831] serum amyloid A 3 [Source:MGI Symbol;Acc:MGI:98223] BCL2 modifying factor [Source:MGI Symbol;Acc:MGI:2176433] proline-rich nuclear receptor coactivator 1 [Source:MGI Symbol;Acc:MGI:1917838] thrombospondin 1 [Source:MGI Symbol;Acc:MGI:98737] BTB and CNC homology, basic leucine zipper transcription factor 2 [Source:MGI Symbol;Acc:MGI:894679] protein kinase C and casein kinase substrate in neurons 1 [Source:MGI Symbol;Acc:MGI:1345181] hepatitis A virus cellular receptor 1 [Source:MGI Symbol;Acc:MGI:2159680] toll-like receptor 8 [Source:MGI Symbol;Acc:MGI:2176887] CD79B antigen [Source:MGI Symbol;Acc:MGI:96431] pleckstrin homology domain containing, family G (with RhoGef domain) member 1 [Source:MGI Symbol;Acc:MGI cardiotrophin-like cytokine factor 1 [Source:MGI Symbol;Acc:MGI:1930088] solute carrier organic anion transporter family, member 4C1 [Source:MGI Symbol;Acc:MGI:2442784] BSD domain containing 1 [Source:MGI Symbol;Acc:MGI:1913466] receptor (calcitonin) activity modifying protein 3 [Source:MGI Symbol;Acc:MGI:1860292] phospholipase A2, group IID [Source:MGI Symbol;Acc:MGI:1341796] inhibin beta-A [Source:MGI Symbol;Acc:MGI:96570] myocardial zonula adherens protein [Source:MGI Symbol;Acc:MGI:2142908] serine (or cysteine) peptidase inhibitor, clade A, member 3G [Source:MGI Symbol;Acc:MGI:105046] patched domain containing 1 [Source:MGI Symbol;Acc:MGI:2685233] 2'-5' oligoadenylate synthetase-like 1 [Source:MGI Symbol;Acc:MGI:2180849] synaptotagmin-like 3 [Source:MGI Symbol;Acc:MGI:1933367] triggering receptor expressed on myeloid cells 1 [Source:MGI Symbol;Acc:MGI:1930005] solute carrier family 26, member 9 [Source:MGI Symbol;Acc:MGI:2444594] stabilin 1 [Source:MGI Symbol;Acc:MGI:2178742] cyclin O [Source:MGI Symbol;Acc:MGI:2145534] reelin [Source:MGI Symbol;Acc:MGI:103022] Fc fragment of IgM receptor [Source:MGI Symbol;Acc:MGI:1916419] kelch-like 14 [Source:MGI Symbol;Acc:MGI:1921249] lysine (K)-specific demethylase 7A [Source:MGI Symbol;Acc:MGI:2443388] v- musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) [Source:MGI Symbol;Acc:MGI:96910 zinc finger CCCH type containing 12A [Source:MGI Symbol;Acc:MGI:2385891] mitogen-activated protein kinase kinase kinase 9 [Source:MGI Symbol;Acc:MGI:2449952] apolipoprotein B receptor [Source:MGI Symbol;Acc:MGI:2176230] G protein-coupled receptor 153 [Source:MGI Symbol;Acc:MGI:1916157] HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 [Source:MGI Symbol;Acc:MGI:2685817] hypermethylated in cancer 1 [Source:MGI Symbol;Acc:MGI:1338010] RIKEN cDNA 4930426D05 gene [Source:MGI Symbol;Acc:MGI:1921894] family with sequence similarity 129, member C [Source:MGI Symbol;Acc:MGI:3686743] patatin-like phospholipase domain containing 1 [Source:MGI Symbol;Acc:MGI:3617850] filamin A interacting protein 1-like [Source:MGI Symbol;Acc:MGI:1925999]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

RIKEN cDNA B430306N03 gene [Source:MGI Symbol;Acc:MGI:2443478] proline rich 33 [Source:MGI Symbol;Acc:MGI:3642289] C-type lectin domain family 4, member a3 [Source:MGI Symbol;Acc:MGI:1920399] RIKEN cDNA A530064D06 gene [Source:MGI Symbol;Acc:MGI:2443476] chemokine (C-C motif) receptor-like 2 [Source:MGI Symbol;Acc:MGI:1920904] interleukin 1 family, member 9 [Source:MGI Symbol;Acc:MGI:2449929] ATP-binding cassette, sub-family A (ABC1), member 6 [Source:MGI Symbol;Acc:MGI:1923434] zinc finger protein 36 [Source:MGI Symbol;Acc:MGI:99180] olfactory receptor 543 [Source:MGI Symbol;Acc:MGI:3030377] tubulin, beta 2B class IIB [Source:MGI Symbol;Acc:MGI:1920960] transmembrane protein 88 [Source:MGI Symbol;Acc:MGI:1914270] hydroxycarboxylic acid receptor 2 [Source:MGI Symbol;Acc:MGI:1933383] formyl peptide receptor 1 [Source:MGI Symbol;Acc:MGI:107443] phosphotyrosine interaction domain containing 1 [Source:MGI Symbol;Acc:MGI:2138391] collagen, type XXVII, alpha 1 [Source:MGI Symbol;Acc:MGI:2672118] interferon induced transmembrane protein 10 [Source:MGI Symbol;Acc:MGI:2444776] neuronal PAS domain protein 4 [Source:MGI Symbol;Acc:MGI:2664186] Grb2-binding adaptor, transmembrane [Source:MGI Symbol;Acc:MGI:3608341] , receptor [Source:MGI Symbol;Acc:MGI:97612] paired immunoglobin-like type 2 receptor alpha [Source:MGI Symbol;Acc:MGI:2450529] transmembrane protein 45A2 [Source:MGI Symbol;Acc:MGI:1916707] ras homolog family member J [Source:MGI Symbol;Acc:MGI:1931551] leucine rich repeat containing 75B [Source:MGI Symbol;Acc:MGI:2143657] immunity-related GTPase family M member 1 [Source:MGI Symbol;Acc:MGI:107567] zinc finger and BTB domain containing 21 [Source:MGI Symbol;Acc:MGI:1927240] neuralized E3 ubiquitin protein ligase 3 [Source:MGI Symbol;Acc:MGI:2429944] ribonuclease, RNase A family, 2A (liver, eosinophil-derived neurotoxin) [Source:MGI Symbol;Acc:MGI:1890465] TGFB-induced factor homeobox 1 [Source:MGI Symbol;Acc:MGI:1194497] uronyl-2-sulfotransferase [Source:MGI Symbol;Acc:MGI:2442406] CD300 molecule like family member F [Source:MGI Symbol;Acc:MGI:2442359] GTPase, IMAP family member 6 [Source:MGI Symbol;Acc:MGI:1918876] chemokine (C-X-C motif) receptor 5 [Source:MGI Symbol;Acc:MGI:103567] glycoprotein 5 (platelet) [Source:MGI Symbol;Acc:MGI:1096363] junction adhesion molecule like [Source:MGI Symbol;Acc:MGI:2685484] predicted gene 6377 [Source:MGI Symbol;Acc:MGI:3647255] interferon beta 1, fibroblast [Source:MGI Symbol;Acc:MGI:107657] predicted gene 12185 [Source:MGI Symbol;Acc:MGI:3652173] C-type lectin domain family 4, member a1 [Source:MGI Symbol;Acc:MGI:3036291] G protein-coupled receptor 137C [Source:MGI Symbol;Acc:MGI:1917963] protocadherin 10 [Source:MGI Symbol;Acc:MGI:1338042] complement component 5a receptor 1 [Source:MGI Symbol;Acc:MGI:88232] sortilin-related receptor, LDLR class A repeats-containing [Source:MGI Symbol;Acc:MGI:1202296] spermatogenesis and centriole associated 1 [Source:MGI Symbol;Acc:MGI:1921531] cDNA sequence BC048671 [Source:MGI Symbol;Acc:MGI:2679261] ADP-ribosylation factor-like 4C [Source:MGI Symbol;Acc:MGI:2445172] RAS-like, family 11, member B [Source:MGI Symbol;Acc:MGI:1916189] leucine rich repeat containing 25 [Source:MGI Symbol;Acc:MGI:2445284] sterile alpha and HEAT/Armadillo motif containing 1 [Source:MGI Symbol;Acc:MGI:2136419] predicted gene 867 [Source:MGI Symbol;Acc:MGI:2685713] EvC ciliary complex subunit 2 [Source:MGI Symbol;Acc:MGI:1915775]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

lectin, galactose binding, soluble 3 [Source:MGI Symbol;Acc:MGI:96778] astacin-like metalloendopeptidase (M12 family) [Source:MGI Symbol;Acc:MGI:3046414] F-box and leucine-rich repeat protein 22 [Source:MGI Symbol;Acc:MGI:1921415] matrix metallopeptidase 13 [Source:MGI Symbol;Acc:MGI:1340026] piggyBac transposable element derived 5 [Source:MGI Symbol;Acc:MGI:2429955] purinergic receptor P2Y, G-protein coupled 10 [Source:MGI Symbol;Acc:MGI:1926076] lin-28 homolog A (C. elegans) [Source:MGI Symbol;Acc:MGI:1890546] family with sequence similarity 160, member A1 [Source:MGI Symbol;Acc:MGI:2444746] glucose-fructose oxidoreductase domain containing 1 [Source:MGI Symbol;Acc:MGI:2145304] sterile alpha motif domain containing 3 [Source:MGI Symbol;Acc:MGI:2685469] CD14 antigen [Source:MGI Symbol;Acc:MGI:88318] forkhead box D4 [Source:MGI Symbol;Acc:MGI:1347467] sialic acid binding Ig-like lectin H [Source:MGI Symbol;Acc:MGI:2443256] olfactory receptor 414 [Source:MGI Symbol;Acc:MGI:3030248] triggering receptor expressed on myeloid cells-like 4 [Source:MGI Symbol;Acc:MGI:1923239] WAP four-disulfide core domain 21 [Source:MGI Symbol;Acc:MGI:1913357] B and T lymphocyte associated [Source:MGI Symbol;Acc:MGI:2658978] Kruppel-like factor 13 [Source:MGI Symbol;Acc:MGI:1354948] RIKEN cDNA D630039A03 gene [Source:MGI Symbol;Acc:MGI:2442889] CD177 antigen [Source:MGI Symbol;Acc:MGI:1916141] formyl peptide receptor 2 [Source:MGI Symbol;Acc:MGI:1278319] hemoglobin, beta adult s chain [Source:MGI Symbol;Acc:MGI:5474852] RIKEN cDNA C130026I21 gene [Source:MGI Symbol;Acc:MGI:3612702] pre B cell leukemia homeobox 1 [Source:MGI Symbol;Acc:MGI:97495] jun B proto-oncogene [Source:MGI Symbol;Acc:MGI:96647] protein kinase C, beta [Source:MGI Symbol;Acc:MGI:97596] cAMP responsive element binding protein 5 [Source:MGI Symbol;Acc:MGI:2443973] CD8 antigen, beta chain 1 [Source:MGI Symbol;Acc:MGI:88347] G protein-coupled receptor 141 [Source:MGI Symbol;Acc:MGI:2672983] T cell-interacting, activating receptor on myeloid cells 1 [Source:MGI Symbol;Acc:MGI:2442280] hormonally upregulated Neu-associated kinase [Source:MGI Symbol;Acc:MGI:1347352] immediate early response 2 [Source:MGI Symbol;Acc:MGI:104815] calcium/calmodulin-dependent protein kinase II, delta [Source:MGI Symbol;Acc:MGI:1341265] CD8 antigen, alpha chain [Source:MGI Symbol;Acc:MGI:88346] interferon inducible GTPase 1 [Source:MGI Symbol;Acc:MGI:1926259] family with sequence similarity 83, member E [Source:MGI Symbol;Acc:MGI:1921063] carcinoembryonic antigen-related cell adhesion molecule 10 [Source:MGI Symbol;Acc:MGI:1347248] GTPase, IMAP family member 4 [Source:MGI Symbol;Acc:MGI:1349656] Rho family GTPase 1 [Source:MGI Symbol;Acc:MGI:2444878] stefin A3 [Source:MGI Symbol;Acc:MGI:106196] RIKEN cDNA 9430025C20 gene [Source:MGI Symbol;Acc:MGI:3045277] microtubule-associated protein 6 [Source:MGI Symbol;Acc:MGI:1201690] avian musculoaponeurotic fibrosarcoma oncogene homolog [Source:MGI Symbol;Acc:MGI:96909] T cell immunoglobulin and mucin domain containing 4 [Source:MGI Symbol;Acc:MGI:2445125] fucosyltransferase 2 [Source:MGI Symbol;Acc:MGI:109374] chloride channel accessory 3A1 [Source:MGI Symbol;Acc:MGI:1316732] S100 calcium binding protein A8 (calgranulin A) [Source:MGI Symbol;Acc:MGI:88244] S100 calcium binding protein A9 (calgranulin B) [Source:MGI Symbol;Acc:MGI:1338947] transmembrane protein 154 [Source:MGI Symbol;Acc:MGI:2444725] platelet-activating factor receptor [Source:MGI Symbol;Acc:MGI:106066]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

ring finger protein, LIM domain interacting [Source:MGI Symbol;Acc:MGI:1342291] apolipoprotein L 8 [Source:MGI Symbol;Acc:MGI:2444921] immediate early response 5 [Source:MGI Symbol;Acc:MGI:1337072] early B cell factor 1 [Source:MGI Symbol;Acc:MGI:95275] cDNA sequence AB124611 [Source:MGI Symbol;Acc:MGI:3043001] carbohydrate (chondroitin 6/keratan) sulfotransferase 3 [Source:MGI Symbol;Acc:MGI:1858224] androgen dependent TFPI regulating protein [Source:MGI Symbol;Acc:MGI:1924596] chemokine (C-X-C motif) ligand 2 [Source:MGI Symbol;Acc:MGI:1340094] oncostatin M [Source:MGI Symbol;Acc:MGI:104749] paired Ig-like receptor B [Source:MGI Symbol;Acc:MGI:894311] Fc receptor, IgG, low affinity IV [Source:MGI Symbol;Acc:MGI:2179523] interferon induced transmembrane protein 6 [Source:MGI Symbol;Acc:MGI:2686976] Fc receptor, IgG, low affinity III [Source:MGI Symbol;Acc:MGI:95500] stefin A2 like 1 [Source:MGI Symbol;Acc:MGI:3524944] a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14 [Source:MGI Sym Fc receptor-like 1 [Source:MGI Symbol;Acc:MGI:2442862] myosin, heavy polypeptide 13, skeletal muscle [Source:MGI Symbol;Acc:MGI:1339967] synaptonemal complex protein 2 [Source:MGI Symbol;Acc:MGI:1933281] tumor necrosis factor receptor superfamily, member 19 [Source:MGI Symbol;Acc:MGI:1352474] histocompatibility 2, class II antigen E beta [Source:MGI Symbol;Acc:MGI:95901] B cell linker [Source:MGI Symbol;Acc:MGI:96878] recombination activating gene 1 [Source:MGI Symbol;Acc:MGI:97848] chemokine (C-X-C motif) ligand 12 [Source:MGI Symbol;Acc:MGI:103556] interferon lambda receptor 1 [Source:MGI Symbol;Acc:MGI:2429859] serine (or cysteine) peptidase inhibitor, clade B, member 2 [Source:MGI Symbol;Acc:MGI:97609] fatty acid binding protein 4, adipocyte [Source:MGI Symbol;Acc:MGI:88038] diacylglycerol kinase, epsilon, opposite strand [Source:MGI Symbol;Acc:MGI:3041185] ribosomal protein S4-like [Source:MGI Symbol;Acc:MGI:1913434] 1-related peptidase b27 [Source:MGI Symbol;Acc:MGI:891980] zinc finger with KRAB and SCAN domains 8 [Source:MGI Symbol;Acc:MGI:1913815] kallikrein 1 [Source:MGI Symbol;Acc:MGI:102850] interaction protein for cytohesin exchange factors 1 [Source:MGI Symbol;Acc:MGI:2444159] chitinase-like 1 [Source:MGI Symbol;Acc:MGI:1340899] mitochondrially encoded 12S rRNA [Source:MGI Symbol;Acc:MGI:102493] predicted gene, 24252 [Source:MGI Symbol;Acc:MGI:5454029] interferon activated gene 208 [Source:MGI Symbol;Acc:MGI:2442822] paired immunoglobin-like type 2 receptor beta 2 [Source:MGI Symbol;Acc:MGI:2450535] paired immunoglobin-like type 2 receptor beta 1 [Source:MGI Symbol;Acc:MGI:2450532] immunoglobulin joining chain [Source:MGI Symbol;Acc:MGI:96493] interferon induced protein with tetratricopeptide repeats 1B like 2 [Source:MGI Symbol;Acc:MGI:2148249] keratin 83 [Source:MGI Symbol;Acc:MGI:3690448] tumor necrosis factor receptor superfamily, member 13c [Source:MGI Symbol;Acc:MGI:1919299] interleukin 2 receptor, beta chain [Source:MGI Symbol;Acc:MGI:96550] zinc finger and BTB domain containing 10 [Source:MGI Symbol;Acc:MGI:2139883] lysozyme 1 [Source:MGI Symbol;Acc:MGI:96902] lysozyme 2 [Source:MGI Symbol;Acc:MGI:96897] myristoylated alanine rich protein kinase C substrate [Source:MGI Symbol;Acc:MGI:96907] AHNAK nucleoprotein (desmoyokin) [Source:MGI Symbol;Acc:MGI:1316648] poly(A)binding protein nuclear 1-like [Source:MGI Symbol;Acc:MGI:2685954] RIKEN cDNA 4930438A08 gene [Source:MGI Symbol;Acc:MGI:1921238]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

hemoglobin alpha, adult chain 1 [Source:MGI Symbol;Acc:MGI:96015] sodium channel, voltage-gated, type II, beta [Source:MGI Symbol;Acc:MGI:106921] meningioma 1 [Source:MGI Symbol;Acc:MGI:1261813] leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 [Source:MGI Symbol;Acc:MGI actin-like 7a [Source:MGI Symbol;Acc:MGI:1343051] prostaglandin D receptor [Source:MGI Symbol;Acc:MGI:102966] cDNA sequence BC100530 [Source:MGI Symbol;Acc:MGI:3696883] septin 5 [Source:MGI Symbol;Acc:MGI:1195461] predicted gene 10371 [Source:MGI Symbol;Acc:MGI:3642716] eosinophil-associated, ribonuclease A family, member 2 [Source:MGI Symbol;Acc:MGI:108020] eosinophil-associated, ribonuclease A family, pseudogene 2 [Source:MGI Symbol;Acc:MGI:1890466] eosinophil-associated, ribonuclease A family, member 1 [Source:MGI Symbol;Acc:MGI:108021] schlafen 2 [Source:MGI Symbol;Acc:MGI:1313258] RIKEN cDNA G530011O06 gene [Source:MGI Symbol;Acc:MGI:3603513] G protein-coupled receptor 27 [Source:MGI Symbol;Acc:MGI:1202299] hemoglobin, theta 1B [Source:MGI Symbol;Acc:MGI:3613460] RIKEN cDNA 9830107B12 gene [Source:MGI Symbol;Acc:MGI:3608415] histocompatibility 2, class II antigen A, beta 1 [Source:MGI Symbol;Acc:MGI:103070] post-GPI attachment to proteins 1 [Source:MGI Symbol;Acc:MGI:2443342] hemoglobin, beta adult t chain [Source:MGI Symbol;Acc:MGI:5474850] oxidative stress induced growth inhibitor 1 [Source:MGI Symbol;Acc:MGI:1919089] neurotrophin 5 [Source:MGI Symbol;Acc:MGI:97381] NLR family, CARD domain containing 5 [Source:MGI Symbol;Acc:MGI:3612191] GRAM domain containing 2 [Source:MGI Symbol;Acc:MGI:3528937] carcinoembryonic antigen-related cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:1347245] predicted gene 14548 [Source:MGI Symbol;Acc:MGI:3709645] predicted gene 15448 [Source:MGI Symbol;Acc:MGI:3705216] glucosaminyl (N-acetyl) transferase family member 7 [Source:MGI Symbol;Acc:MGI:3606143] Cas scaffolding protein family member 4 [Source:MGI Symbol;Acc:MGI:2444482] v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) [Source:MGI Symbol;Acc:MGI:10455 signal-regulatory protein beta 1C [Source:MGI Symbol;Acc:MGI:3807521] arrestin domain containing 3 [Source:MGI Symbol;Acc:MGI:2145242] RIKEN cDNA F930017D23 gene [Source:MGI Symbol;Acc:MGI:3822538] zinc finger and BTB domain containing 2 [Source:MGI Symbol;Acc:MGI:2685949] immunoglobulin lambda-like polypeptide 1 [Source:MGI Symbol;Acc:MGI:96529] T cell receptor beta, constant 2 [Source:MGI Symbol;Acc:MGI:4835227] immunoglobulin kappa chain variable 15-103 [Source:MGI Symbol;Acc:MGI:96513] immunoglobulin kappa variable 1-99 [Source:MGI Symbol;Acc:MGI:4439724] immunoglobulin kappa chain variable 12-89 [Source:MGI Symbol;Acc:MGI:4439829] immunoglobulin kappa variable 4-86 [Source:MGI Symbol;Acc:MGI:2685305] immunoglobulin kappa chain variable 13-84 [Source:MGI Symbol;Acc:MGI:96514] immunoglobulin kappa variable 4-79 [Source:MGI Symbol;Acc:MGI:2685040] immunoglobulin kappa variable 4-74 [Source:MGI Symbol;Acc:MGI:3779447] immunoglobulin kappa chain variable 4-70 [Source:MGI Symbol;Acc:MGI:2686348] immunoglobulin kappa variable 4-68 [Source:MGI Symbol;Acc:MGI:2686265] immunoglobulin kappa chain variable 4-61 [Source:MGI Symbol;Acc:MGI:4439819] immunoglobulin kappa variable 4-57-1 [Source:MGI Symbol;Acc:MGI:2686264] immunoglobulin kappa variable 4-57 [Source:MGI Symbol;Acc:MGI:2685035] immunoglobulin kappa chain variable 7-33 [Source:MGI Symbol;Acc:MGI:3577282] immunoglobulin kappa variable 6-32 [Source:MGI Symbol;Acc:MGI:3641634]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

immunoglobulin kappa chain variable 8-24 [Source:MGI Symbol;Acc:MGI:4947958] immunoglobulin kappa variable 6-20 [Source:MGI Symbol;Acc:MGI:1330836] immunoglobulin kappa variable 8-18 [Source:MGI Symbol;Acc:MGI:1330845] immunoglobulin kappa joining 2 [Source:MGI Symbol;Acc:MGI:1316690] immunoglobulin kappa joining 3 [Source:MGI Symbol;Acc:MGI:1316691] immunoglobulin kappa joining 4 [Source:MGI Symbol;Acc:MGI:1316692] immunoglobulin kappa joining 5 [Source:MGI Symbol;Acc:MGI:1316738] immunoglobulin kappa constant [Source:MGI Symbol;Acc:MGI:96495] immunoglobulin heavy constant gamma 2B [Source:MGI Symbol;Acc:MGI:96445] immunoglobulin heavy constant mu [Source:MGI Symbol;Acc:MGI:96448] immunoglobulin heavy joining 4 [Source:MGI Symbol;Acc:MGI:4439658] immunoglobulin heavy variable 5-2 [Source:MGI Symbol;Acc:MGI:4439893] immunoglobulin heavy variable 7-1 [Source:MGI Symbol;Acc:MGI:4439622] immunoglobulin heavy variable 14-4 [Source:MGI Symbol;Acc:MGI:4439765] immunoglobulin heavy variable V3-8 [Source:MGI Symbol;Acc:MGI:3645298] immunoglobulin heavy variable V12-3 [Source:MGI Symbol;Acc:MGI:3646760] immunoglobulin heavy variable 6-3 [Source:MGI Symbol;Acc:MGI:4439854] immunoglobulin heavy variable 6-6 [Source:MGI Symbol;Acc:MGI:4439619] immunoglobulin heavy variable V1-18 [Source:MGI Symbol;Acc:MGI:4439780] immunoglobulin heavy variable 1-49 [Source:MGI Symbol;Acc:MGI:4439754] T cell receptor alpha constant [Source:MGI Symbol;Acc:MGI:4439838] immunoglobulin lambda variable 1 [Source:MGI Symbol;Acc:MGI:96530] immunoglobulin lambda variable 3 [Source:MGI Symbol;Acc:MGI:3645509] family with sequence similarity 229, member A [Source:MGI Symbol;Acc:MGI:1915483] schlafen 1 [Source:MGI Symbol;Acc:MGI:1313259] ecotropic viral integration site 2a [Source:MGI Symbol;Acc:MGI:95458] predicted gene 5150 [Source:MGI Symbol;Acc:MGI:3779469] protein kinase C, gamma [Source:MGI Symbol;Acc:MGI:97597] NLR family, pyrin domain containing 12 [Source:MGI Symbol;Acc:MGI:2676630] interferon gamma induced GTPase [Source:MGI Symbol;Acc:MGI:107729] interferon gamma inducible protein 47 [Source:MGI Symbol;Acc:MGI:99448] T cell specific GTPase 2 [Source:MGI Symbol;Acc:MGI:3710083] T cell specific GTPase 1 [Source:MGI Symbol;Acc:MGI:98734] collagen, type XXII, alpha 1 [Source:MGI Symbol;Acc:MGI:1916950] toll-like receptor 5 [Source:MGI Symbol;Acc:MGI:1858171] C-type lectin domain family 7, member a [Source:MGI Symbol;Acc:MGI:1861431] predicted pseudogene 16026 [Source:MGI Symbol;Acc:MGI:3783243] UTP14B small subunit processome component [Source:MGI Symbol;Acc:MGI:2445092] NHS-like 2 [Source:MGI Symbol;Acc:MGI:3645090] predicted gene 5483 [Source:MGI Symbol;Acc:MGI:3645124] major urinary protein, pseudogene 22 [Source:MGI Symbol;Acc:MGI:3651342] predicted gene 15922 [Source:MGI Symbol;Acc:MGI:3802148] predicted gene 15931 [Source:MGI Symbol;Acc:MGI:3805553] schlafen 14 [Source:MGI Symbol;Acc:MGI:2684866] predicted gene 11212 [Source:MGI Symbol;Acc:MGI:3651243] predicted gene 12250 [Source:MGI Symbol;Acc:MGI:3649299] predicted gene 14780 [Source:MGI Symbol;Acc:MGI:3705499] predicted gene 13450 [Source:MGI Symbol;Acc:MGI:3650133] predicted gene 13357 [Source:MGI Symbol;Acc:MGI:3651263] predicted gene 11699 [Source:MGI Symbol;Acc:MGI:3650316]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

predicted gene 12337 [Source:MGI Symbol;Acc:MGI:3650615] RIKEN cDNA B430010I23 gene [Source:MGI Symbol;Acc:MGI:1926099] Mir22 host gene (non-protein coding) [Source:MGI Symbol;Acc:MGI:1914348] predicted gene 13185 [Source:MGI Symbol;Acc:MGI:3651411] homeobox B5 and homeobox B6, opposite strand [Source:MGI Symbol;Acc:MGI:1922645] predicted gene 16193 [Source:MGI Symbol;Acc:MGI:3802025] predicted gene 15326 [Source:MGI Symbol;Acc:MGI:3705205] RIKEN cDNA F730016J06 gene [Source:MGI Symbol;Acc:MGI:2443559] CD101 antigen [Source:MGI Symbol;Acc:MGI:2685862] predicted gene 11827 [Source:MGI Symbol;Acc:MGI:3649801] predicted gene 11714 [Source:MGI Symbol;Acc:MGI:3649214] predicted gene 16152 [Source:MGI Symbol;Acc:MGI:3802058] predicted gene 14820 [Source:MGI Symbol;Acc:MGI:3713695] predicted gene 15818 [Source:MGI Symbol;Acc:MGI:3801960] predicted gene 15726 [Source:MGI Symbol;Acc:MGI:3783169] RasGEF domain family, member 1B [Source:MGI Symbol;Acc:MGI:2443755] predicted gene 8459 [Source:MGI Symbol;Acc:MGI:3647456] paired-Ig-like receptor A2 [Source:MGI Symbol;Acc:MGI:1195970] eosinophil-associated, ribonuclease A family, member 10 [Source:MGI Symbol;Acc:MGI:1890464] predicted gene 16556 [Source:MGI Symbol;Acc:MGI:4414976] predicted gene 16028 [Source:MGI Symbol;Acc:MGI:3801982] RIKEN cDNA 1700071M16 gene [Source:MGI Symbol;Acc:MGI:1920754] predicted gene 17056 [Source:MGI Symbol;Acc:MGI:4937883] predicted gene, 17455 [Source:MGI Symbol;Acc:MGI:4937089] predicted gene 17083 [Source:MGI Symbol;Acc:MGI:4937910] glutamate decarboxylase 1, pseudogene [Source:MGI Symbol;Acc:MGI:95633] apolipoprotein L domain containing 1 [Source:MGI Symbol;Acc:MGI:2685921] predicted gene 17116 [Source:MGI Symbol;Acc:MGI:4937943] family with sequence similarity 71, member A [Source:MGI Symbol;Acc:MGI:3588202] collagen, type VI, alpha 5 [Source:MGI Symbol;Acc:MGI:3648134] apolipoprotein L 11b [Source:MGI Symbol;Acc:MGI:3036248] metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) [Source:MGI Symbol;Acc:MGI:191953 predicted gene 20405 [Source:MGI Symbol;Acc:MGI:5141870] ADP-ribosyltransferase 2a, pseudogene [Source:MGI Symbol;Acc:MGI:107546] microRNA 5107 [Source:MGI Symbol;Acc:MGI:4950427] RIKEN cDNA A730085K08 gene [Source:MGI Symbol;Acc:MGI:3605633] immunoglobulin kappa variable 1-110 [Source:MGI Symbol;Acc:MGI:4439558] immunoglobulin heavy variable 1-53 [Source:MGI Symbol;Acc:MGI:3576502] immunoglobulin kappa variable 9-129 [Source:MGI Symbol;Acc:MGI:3525017] immunoglobulin heavy variable 1-34 [Source:MGI Symbol;Acc:MGI:4439659] MAS-related GPR, member A2A [Source:MGI Symbol;Acc:MGI:3821888] immunoglobulin heavy variable V3-3 [Source:MGI Symbol;Acc:MGI:3643949] immunoglobulin heavy variable 1-64 [Source:MGI Symbol;Acc:MGI:4439789] immunoglobulin heavy variable V1-74 [Source:MGI Symbol;Acc:MGI:4439634] immunoglobulin heavy variable 5-15 [Source:MGI Symbol;Acc:MGI:4439812] immunoglobulin heavy variable 5-16 [Source:MGI Symbol;Acc:MGI:4439556] immunoglobulin kappa variable 1-117 [Source:MGI Symbol;Acc:MGI:4439721] immunoglobulin kappa variable 8-28 [Source:MGI Symbol;Acc:MGI:3642251] immunoglobulin kappa variable 10-96 [Source:MGI Symbol;Acc:MGI:4439561] immunoglobulin kappa chain variable 5-43 [Source:MGI Symbol;Acc:MGI:4943320]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

transmembrane protein 121B [Source:MGI Symbol;Acc:MGI:2136977] immunoglobulin heavy variable 1-81 [Source:MGI Symbol;Acc:MGI:4439635] immunoglobulin kappa variable 6-15 [Source:MGI Symbol;Acc:MGI:1330831] immunoglobulin kappa chain variable 9-120 [Source:MGI Symbol;Acc:MGI:3647784] immunoglobulin kappa chain variable 6-25 [Source:MGI Symbol;Acc:MGI:4439867] immunoglobulin heavy variable 5-6 [Source:MGI Symbol;Acc:MGI:4439815] signal-regulatory protein beta 1B [Source:MGI Symbol;Acc:MGI:3779828] RIKEN cDNA E030018B13 gene [Source:MGI Symbol;Acc:MGI:2686543] immunoglobulin heavy constant alpha [Source:MGI Symbol;Acc:MGI:96444] EDAR (ectodysplasin-A receptor)-associated death domain [Source:MGI Symbol;Acc:MGI:1931001] immunoglobulin heavy variable V8-11 [Source:MGI Symbol;Acc:MGI:3644925] immunoglobulin heavy variable V1-7 [Source:MGI Symbol;Acc:MGI:3704122] immunoglobulin heavy variable 5-9-1 [Source:MGI Symbol;Acc:MGI:4439810] immunoglobulin heavy variable 5-9 [Source:MGI Symbol;Acc:MGI:4439873] immunoglobulin kappa chain variable 3-5 [Source:MGI Symbol;Acc:MGI:1330854] immunoglobulin kappa variable 3-2 [Source:MGI Symbol;Acc:MGI:1330850] immunoglobulin heavy variable V1-12 [Source:MGI Symbol;Acc:MGI:3646284] immunoglobulin heavy variable 5-12 [Source:MGI Symbol;Acc:MGI:4439516] immunoglobulin heavy variable 1-4 [Source:MGI Symbol;Acc:MGI:4439618] immunoglobulin heavy variable 5-17 [Source:MGI Symbol;Acc:MGI:4439533] immunoglobulin heavy variable 1-55 [Source:MGI Symbol;Acc:MGI:4439716] immunoglobulin heavy variable 5-4 [Source:MGI Symbol;Acc:MGI:4439895] immunoglobulin kappa variable 6-23 [Source:MGI Symbol;Acc:MGI:3711980] immunoglobulin kappa variable 4-58 [Source:MGI Symbol;Acc:MGI:2685923] immunoglobulin heavy variable V14-3 [Source:MGI Symbol;Acc:MGI:4439764] immunoglobulin heavy variable V1-20 [Source:MGI Symbol;Acc:MGI:3644607] signal-regulatory protein beta 1A [Source:MGI Symbol;Acc:MGI:2444824] immunoglobulin heavy variable V2-4 [Source:MGI Symbol;Acc:MGI:3643263] immunoglobulin heavy variable 1-37 [Source:MGI Symbol;Acc:MGI:4439640] immunoglobulin heavy variable 10-1 [Source:MGI Symbol;Acc:MGI:4439620] spectrin repeat containing, nuclear envelope 1 [Source:MGI Symbol;Acc:MGI:1927152] immunoglobulin heavy variable 1-85 [Source:MGI Symbol;Acc:MGI:3645723] H1 histone family, member 0 [Source:MGI Symbol;Acc:MGI:95893] immunoglobulin heavy variable 1-78 [Source:MGI Symbol;Acc:MGI:4439736] immunoglobulin kappa variable 1-135 [Source:MGI Symbol;Acc:MGI:3819952] immunoglobulin kappa variable 12-44 [Source:MGI Symbol;Acc:MGI:4439775] immunoglobulin heavy variable 1-77 [Source:MGI Symbol;Acc:MGI:4439670] immunoglobulin kappa variable 14-130 [Source:MGI Symbol;Acc:MGI:3645770] immunoglobulin heavy variable 2-2 [Source:MGI Symbol;Acc:MGI:4439894] immunoglobulin heavy variable V1-5 [Source:MGI Symbol;Acc:MGI:3704121] immunoglobulin kappa chain variable 14-100 [Source:MGI Symbol;Acc:MGI:4439559] immunoglobulin kappa variable 8-19 [Source:MGI Symbol;Acc:MGI:1330844] immunoglobulin kappa chain variable 9-124 [Source:MGI Symbol;Acc:MGI:3646892] immunoglobulin kappa variable 6-14 [Source:MGI Symbol;Acc:MGI:1330830] RIKEN cDNA A330023F24 gene [Source:MGI Symbol;Acc:MGI:2443958] predicted gene, 26551 [Source:MGI Symbol;Acc:MGI:5477045] predicted gene 2449 [Source:MGI Symbol;Acc:MGI:3780616] predicted gene, 26802 [Source:MGI Symbol;Acc:MGI:5477296] predicted gene, 26648 [Source:MGI Symbol;Acc:MGI:5477142] Mir155 host gene (non-protein coding) [Source:MGI Symbol;Acc:MGI:5477161]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

predicted gene, 26586 [Source:MGI Symbol;Acc:MGI:5477080] myocardial infarction associated transcript 1 [Source:MGI Symbol;Acc:MGI:1922001] predicted gene, 16853 [Source:MGI Symbol;Acc:MGI:4439777] prostaglandin-endoperoxide synthase 2, opposite strand 2 [Source:MGI Symbol;Acc:MGI:5477181] RIKEN cDNA 4833407H14 gene [Source:MGI Symbol;Acc:MGI:1921149] pluripotency-associated noncoding transcript 2 [Source:MGI Symbol;Acc:MGI:3643517] predicted gene, 26756 [Source:MGI Symbol;Acc:MGI:5477250] predicted gene, 16894 [Source:MGI Symbol;Acc:MGI:4439818] predicted gene, 26980 [Source:MGI Symbol;Acc:MGI:5504095] sosondowah ankyrin repeat domain family member C [Source:MGI Symbol;Acc:MGI:3606051] predicted gene 7985 [Source:MGI Symbol;Acc:MGI:3645837] transcription factor 24 [Source:MGI Symbol;Acc:MGI:3780500] oocyte specific homeobox 8 [Source:MGI Symbol;Acc:MGI:3645855] high mobility group box 1, related sequence 16 [Source:MGI Symbol;Acc:MGI:104765] RIKEN cDNA 1700047M11 gene [Source:MGI Symbol;Acc:MGI:1914580] RIKEN cDNA F730311O21 gene [Source:MGI Symbol;Acc:MGI:3643355] predicted gene, 17971 [Source:MGI Symbol;Acc:MGI:5010156] RIKEN cDNA 4732465J04 gene [Source:MGI Symbol;Acc:MGI:3041208] predicted gene 5441 [Source:MGI Symbol;Acc:MGI:3779489] RIKEN cDNA I830127L07 gene [Source:MGI Symbol;Acc:MGI:3612406] predicted gene, 38257 [Source:MGI Symbol;Acc:MGI:5611485] immunoglobulin heavy variable V8-5 [Source:MGI Symbol;Acc:MGI:3645478] immunoglobulin heavy variable V1-29 [Source:MGI Symbol;Acc:MGI:5009909] predicted gene, 37569 [Source:MGI Symbol;Acc:MGI:5610797] predicted gene, 37726 [Source:MGI Symbol;Acc:MGI:5610954] immunoglobulin heavy variable 1-33 [Source:MGI Symbol;Acc:MGI:4439617] RIKEN cDNA 9430034N14 gene [Source:MGI Symbol;Acc:MGI:2444791] predicted gene, 37347 [Source:MGI Symbol;Acc:MGI:5610575] predicted gene, 37558 [Source:MGI Symbol;Acc:MGI:5610786] predicted gene, 37642 [Source:MGI Symbol;Acc:MGI:5610870] immunoglobulin heavy variable 1-15 [Source:MGI Symbol;Acc:MGI:4439782] immunoglobulin heavy variable V1-23 [Source:MGI Symbol;Acc:MGI:3815050] predicted gene, 37802 [Source:MGI Symbol;Acc:MGI:5611030] predicted gene, 37403 [Source:MGI Symbol;Acc:MGI:5610631] predicted gene, 38365 [Source:MGI Symbol;Acc:MGI:5611593] predicted gene, 37522 [Source:MGI Symbol;Acc:MGI:5610750] RIKEN cDNA D430013B06 gene [Source:MGI Symbol;Acc:MGI:3026994] predicted gene, 37420 [Source:MGI Symbol;Acc:MGI:5610648] immunoglobulin heavy variable V3-4 [Source:MGI Symbol;Acc:MGI:3644034] RIKEN cDNA 5730488B01 gene [Source:MGI Symbol;Acc:MGI:1917852] predicted gene, 20743 [Source:MGI Symbol;Acc:MGI:5434099] immunoglobulin heavy constant delta [Source:MGI Symbol;Acc:MGI:96447] predicted gene, 38043 [Source:MGI Symbol;Acc:MGI:5611271] predicted gene, 37689 [Source:MGI Symbol;Acc:MGI:5610917] predicted gene, 37065 [Source:MGI Symbol;Acc:MGI:5610293] immunoglobulin heavy variable 8-8 [Source:MGI Symbol;Acc:MGI:3815333] predicted gene 42941 [Source:MGI Symbol;Acc:MGI:5663078] RIKEN cDNA 1700008B11 gene [Source:MGI Symbol;Acc:MGI:1913571] predicted gene 43388 [Source:MGI Symbol;Acc:MGI:5663525] predicted gene 42870 [Source:MGI Symbol;Acc:MGI:5663007]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

predicted gene 42869 [Source:MGI Symbol;Acc:MGI:5663006] RIKEN cDNA 6030400A10 gene [Source:MGI Symbol;Acc:MGI:1924319] predicted gene 43817 [Source:MGI Symbol;Acc:MGI:5663954] predicted gene 43359 [Source:MGI Symbol;Acc:MGI:5663496] predicted gene 43200 [Source:MGI Symbol;Acc:MGI:5663337] predicted gene 42436 [Source:MGI Symbol;Acc:MGI:5662573] immunoglobulin lambda constant 3 [Source:MGI Symbol;Acc:MGI:99886] immunoglobulin heavy variable 1-86 [Source:MGI Symbol;Acc:MGI:3645729] immunoglobulin kappa variable 2-109 [Source:MGI Symbol;Acc:MGI:3642626] predicted gene, 30211 [Source:MGI Symbol;Acc:MGI:5589370] immunoglobulin heavy variable 1-83 [Source:MGI Symbol;Acc:MGI:3648939] immunoglobulin lambda constant 1 [Source:MGI Symbol;Acc:MGI:99546] predicted gene 43221 [Source:MGI Symbol;Acc:MGI:5663358] predicted gene 43430 [Source:MGI Symbol;Acc:MGI:5663567] predicted gene 43484 [Source:MGI Symbol;Acc:MGI:5663621] predicted gene 42820 [Source:MGI Symbol;Acc:MGI:5662957] predicted gene 43181 [Source:MGI Symbol;Acc:MGI:5663318] predicted gene 42632 [Source:MGI Symbol;Acc:MGI:5662769] predicted gene 8774 [Source:MGI Symbol;Acc:MGI:3646210] predicted gene, 44164 [Source:MGI Symbol;Acc:MGI:5690556] predicted gene, 44401 [Source:MGI Symbol;Acc:MGI:5690793] predicted gene, 44053 [Source:MGI Symbol;Acc:MGI:5690445] RIKEN cDNA 1810059H22 gene [Source:MGI Symbol;Acc:MGI:1917070] predicted gene, 43984 [Source:MGI Symbol;Acc:MGI:5690376] predicted gene, 44292 [Source:MGI Symbol;Acc:MGI:5690684] predicted gene 45205 [Source:MGI Symbol;Acc:MGI:5753781] predicted gene 44553 [Source:MGI Symbol;Acc:MGI:5753129] predicted gene 45081 [Source:MGI Symbol;Acc:MGI:5753657] predicted gene 45221 [Source:MGI Symbol;Acc:MGI:5753797] predicted gene 45014 [Source:MGI Symbol;Acc:MGI:5753590] EP300 interacting inhibitor of differentiation 3 [Source:MGI Symbol;Acc:MGI:1913591] predicted gene, 33326 [Source:MGI Symbol;Acc:MGI:5592485] predicted gene, 33148 [Source:MGI Symbol;Acc:MGI:5592307] RIKEN cDNA 5830408C22 gene [Source:MGI Symbol;Acc:MGI:1921994] predicted gene 45363 [Source:MGI Symbol;Acc:MGI:5791199] predicted gene 45774 [Source:MGI Symbol;Acc:MGI:5804889] IQ motif containing N [Source:MGI Symbol;Acc:MGI:3708784] predicted gene, 39321 [Source:MGI Symbol;Acc:MGI:5622206] predicted gene, 47087 [Source:MGI Symbol;Acc:MGI:6095814] RIKEN cDNA E030022I16 gene [Source:MGI Symbol;Acc:MGI:2444690] RIKEN cDNA 1700027J07 gene [Source:MGI Symbol;Acc:MGI:1916693] RIKEN cDNA E230014E18 gene [Source:MGI Symbol;Acc:MGI:3045388] leukocyte immunoglobulin-like receptor, subfamily B, member 4B [Source:MGI Symbol;Acc:MGI:102702] leukocyte immunoglobulin-like receptor, subfamily B, member 4A [Source:MGI Symbol;Acc:MGI:102701] predicted gene 3942 [Source:MGI Symbol;Acc:MGI:3782116] novel transcript RIKEN cDNA B230303A05 gene [Source:MGI Symbol;Acc:MGI:3646895] predicted gene, 48569 [Source:MGI Symbol;Acc:MGI:6098130] RIKEN cDNA 5430425K12 gene [Source:MGI Symbol;Acc:MGI:1918666] predicted gene, 49245 [Source:MGI Symbol;Acc:MGI:6118713]

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

predicted gene, 49145 [Source:MGI Symbol;Acc:MGI:6118558] predicted gene, 31814 [Source:MGI Symbol;Acc:MGI:5590973] predicted gene, 31583 [Source:MGI Symbol;Acc:MGI:5590742] myocardial infraction associated transcript 2 [Source:MGI Symbol;Acc:MGI:3642813] predicted gene, 39556 [Source:MGI Symbol;Acc:MGI:5622441] predicted gene, 34095 [Source:MGI Symbol;Acc:MGI:5593254] novel transcript, antisense to Kcnj6 TEC Ewing sarcoma breakpoint region 1 (Ewsr1) pseudogene

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

logFC logCPM LR PValue FDR -1.516782615 6.943279335 9.548799052 0.002000803 0.042283021 -4.721048243 4.081116691 28.03868448 1.18914E-07 2.087E-05 -4.334606156 4.945699037 26.63847853 2.45309E-07 3.74317E-05 -0.717297536 6.356225607 9.764840916 0.001778809 0.038610004 -1.720346578 6.216157984 16.04182482 6.19586E-05 0.002798462 -6.504887301 -1.456620166 24.40830588 7.7932E-07 9.06482E-05 -2.062635709 -0.911634022 11.75704745 0.000606133 0.016949649 -1.535313392 3.155507316 10.53669114 0.001170277 0.028190684 -3.886271312 0.880438504 16.35043758 5.2644E-05 0.002419261 -2.14316812 4.46076304 15.8019241 7.0331E-05 0.003115526 2.561928649 -1.52124543 13.28615364 0.000267373 0.009124367 -3.072698523 1.861156535 23.94596858 9.90775E-07 0.0001074 -1.841930936 5.217599932 16.70249973 4.37233E-05 0.002076634 -2.347218061 3.568500536 12.26621395 0.000461233 0.013820493 -5.034487744 -0.4023299 32.70121583 1.0747E-08 3.47449E-06 -1.800340401 6.047384473 25.57606558 4.25282E-07 5.59793E-05 -2.241072417 0.503029552 13.15175293 0.00028725 0.009589584 1.719753838 1.096337271 9.790804085 0.001753868 0.038339586 -3.253362102 -0.827588981 14.76904715 0.000121514 0.004784736 -6.508834952 2.042785411 101.28544 7.9639E-24 1.46759E-19 -2.754896386 0.762269755 15.58283741 7.89681E-05 0.003424058 -0.765847402 6.373958764 14.15507272 0.000168343 0.006275377 1.666776487 2.433089925 9.933456122 0.001623015 0.036082622 -3.437327278 1.247765097 28.39841267 9.87462E-08 1.95666E-05 -2.28876789 -0.52817488 12.41041719 0.000426945 0.012983088 -1.451344275 4.408982104 17.34047933 3.1246E-05 0.001608382 -2.566178832 -0.047733608 17.30207607 3.18838E-05 0.001632318 -1.364919009 4.596220563 11.17684839 0.000828243 0.021588217 -2.358710896 3.032956165 16.8378347 4.07135E-05 0.001958924 -1.536833025 5.167320564 9.967208671 0.001593529 0.035681108 -2.693348266 3.952761454 14.90125141 0.000113288 0.004509002 -3.605968066 3.287186426 33.06568702 8.90973E-09 3.07238E-06 -4.797517437 2.541013074 31.09548256 2.45642E-08 6.37563E-06 -1.35067658 4.169274199 12.01926328 0.000526535 0.015352831 -2.579257824 5.057360301 19.83870084 8.42593E-06 0.000575085 -3.802412446 3.982460967 20.00622971 7.71903E-06 0.00053077 -2.423456741 2.360630214 12.11488745 0.000500209 0.01472499 -3.11262056 2.141916639 14.64202694 0.000129983 0.005021663 -3.265723635 -0.281563175 18.74743001 1.49224E-05 0.000922096 -2.167987263 2.766092814 10.60501286 0.001127815 0.027600757 -3.581518227 0.120270517 17.64159257 2.66692E-05 0.001441229 -5.259576057 5.952569408 35.35514796 2.74741E-09 1.23486E-06 2.057410638 0.39016119 15.71580994 7.36064E-05 0.003220912 -3.154579852 -1.458294412 17.65485624 2.64838E-05 0.001435423 1.598754288 2.825152047 12.90919457 0.000326972 0.010645653 -5.500902083 -2.143395298 15.04724006 0.000104853 0.004256035 -4.563318711 6.639421824 47.24021761 6.27986E-12 7.71502E-09 -2.418998086 1.574936188 18.97177037 1.32667E-05 0.000837255

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

-4.661517552 3.608629588 45.14829561 1.82665E-11 1.87008E-08 -3.683595522 3.928395002 22.41297124 2.19884E-06 0.000201825 -2.834523905 1.090639963 16.9372467 3.8636E-05 0.001908805 -5.361654466 2.417876551 32.73796389 1.05457E-08 3.4703E-06 -4.391940915 3.124877617 38.81995854 4.64752E-10 2.85481E-07 -3.918657552 -0.094660476 21.2007364 4.13606E-06 0.000320249 -3.748607132 -1.995448328 12.87786381 0.000332492 0.010749393 -4.273612414 3.480150653 24.44122803 7.66115E-07 9.04998E-05 -3.661502323 3.799505413 49.43919043 2.04617E-12 3.77068E-09 -2.563289987 2.657969045 16.45364087 4.98543E-05 0.002325863 -5.357317959 1.589865894 36.20586258 1.77536E-09 8.38879E-07 1.14143919 6.652335568 26.53888073 2.58287E-07 3.83848E-05 1.80310249 1.093229294 13.31881117 0.000262757 0.009026966 -1.568035062 4.942166986 9.281611455 0.002314657 0.047699618 -1.907110021 1.925026293 10.11565401 0.001470153 0.033364497 1.848334535 1.62137726 10.66256189 0.001093259 0.027006126 -3.124748141 6.606455836 19.05378518 1.27085E-05 0.000810357 -4.346807339 1.385431235 28.76696219 8.16318E-08 1.71232E-05 -1.421724454 6.658863131 10.59425387 0.001134397 0.027664387 -5.758697589 0.694131711 60.81851804 6.25864E-15 2.88336E-11 -1.296386419 5.429784957 15.20014907 9.66958E-05 0.004031471 -3.168503061 1.833352356 29.7225661 4.98511E-08 1.16286E-05 -2.698084964 1.044417419 12.54370067 0.000397544 0.012250743 -2.12705668 1.161171556 12.56224382 0.000393619 0.012150097 -5.398415202 -2.194288516 11.40784183 0.000731347 0.019523513 -0.89539043 5.394174621 12.61858911 0.000381929 0.011908962 -3.189758626 0.164755507 13.03728238 0.000305351 0.010120514 -5.423535608 6.267384049 31.99833054 1.54305E-08 4.51355E-06 -3.000448432 -0.075484529 15.07117591 0.000103532 0.00421168 -4.198500278 2.627636856 22.69316105 1.90043E-06 0.000179152 -1.607797493 7.066671489 38.0636611 6.84736E-10 3.82373E-07 -3.554111886 0.922173 24.60841048 7.02445E-07 8.35139E-05 -7.403404498 -0.729307898 26.15255942 3.15479E-07 4.43789E-05 -1.729223665 6.256342925 16.62448429 4.55591E-05 0.002141741 -4.833536932 2.640433476 32.22869147 1.37052E-08 4.14032E-06 -3.662952307 4.060874411 25.29262528 4.92589E-07 6.34785E-05 -2.454980667 4.032623259 24.34504616 8.05336E-07 9.27546E-05 2.427203437 -1.594072272 9.29315846 0.002300112 0.047519462 -2.844137951 -1.381387625 13.75068244 0.000208745 0.007469422 -1.766097449 7.984845596 33.71955773 6.36575E-09 2.49591E-06 -1.600848994 2.302357925 9.9112099 0.001642751 0.036298097 2.285636307 1.931010008 21.7502289 3.10553E-06 0.0002632 2.411939325 -0.54034457 14.16071932 0.000167838 0.006273672 -0.912250469 6.000933447 9.217595629 0.002397001 0.048756917 -1.435840876 3.690331388 10.55651563 0.001157792 0.028049648 -1.795516494 -1.091859121 9.433637746 0.002130413 0.04465448 -5.104781999 -1.01264264 19.60702938 9.51186E-06 0.000632796 -2.24019141 -0.199281633 9.217519926 0.0023971 0.048756917 -1.513832345 6.105783148 11.98523308 0.000536238 0.015508767 -4.661401674 0.925149792 33.88562143 5.84491E-09 2.34152E-06

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

-2.439881221 1.586743618 20.20715667 6.94925E-06 0.000483248 -2.323570069 5.982111115 29.73384777 4.95619E-08 1.16286E-05 -1.050339147 5.094041178 16.81971064 4.11041E-05 0.001967447 -2.295527153 0.633020685 13.24917456 0.0002727 0.00923771 0.849559242 4.765616033 9.398316008 0.002171848 0.045223527 -3.529923706 -0.392709228 16.38705283 5.16367E-05 0.002378905 -1.771713797 6.390520197 31.34431569 2.1609E-08 5.83407E-06 1.930700107 0.338683565 9.867844021 0.001681925 0.037074774 -0.715735995 5.71032547 12.37237038 0.000435734 0.013185069 -2.94527883 1.288390469 10.06594237 0.001510353 0.034067055 -6.442128302 -1.510123455 25.95246972 3.49927E-07 4.77664E-05 2.679775027 0.338841144 26.6959381 2.38122E-07 3.68948E-05 -2.343688519 4.285271052 16.88300318 3.9756E-05 0.001938157 -0.824293131 7.300978515 11.98282041 0.000536933 0.015508767 -2.281304425 -0.522363157 10.36650563 0.001283222 0.030512536 -1.564132664 7.827976826 40.95501325 1.55774E-10 1.14824E-07 -5.422834247 -0.059895265 26.69489264 2.3825E-07 3.68948E-05 -1.733198614 3.847551338 16.27551736 5.4767E-05 0.002498135 -4.218563584 3.209025856 38.705593 4.92795E-10 2.92943E-07 -1.624474278 4.462456304 13.69661785 0.000214841 0.007628306 -6.212936376 -1.671835 21.95604081 2.78967E-06 0.000245972 -2.612104121 4.47282046 25.61195303 4.17446E-07 5.53431E-05 -1.585205207 3.831883904 11.09723256 0.000864566 0.022376727 -5.112146177 0.989633288 23.91554552 1.00656E-06 0.000107842 -0.699591596 7.189693369 9.429493556 0.002135232 0.04465448 -3.632217855 0.549724074 34.58717476 4.07583E-09 1.70703E-06 -4.965342117 4.313046026 28.32720592 1.02446E-07 1.98668E-05 -2.450447829 -0.629913771 16.09399192 6.0275E-05 0.00273583 -1.727957198 0.974786159 12.15313784 0.000490053 0.014542199 -3.195555366 1.249555995 15.38884321 8.75034E-05 0.003724048 -2.436573458 -1.43047377 12.56474049 0.000393093 0.012150097 -5.806786384 -1.960590369 20.76640659 5.18852E-06 0.00038554 0.628109004 8.280400836 9.841972241 0.001705745 0.037554924 -4.282534351 -0.244583084 18.78323902 1.46449E-05 0.000908671 -4.773359604 0.173942609 26.54942579 2.56881E-07 3.83848E-05 -4.41261409 0.707513458 12.5768289 0.000390559 0.012136962 -1.2773499 5.030665631 12.27547576 0.00045895 0.013774469 -1.894730034 3.156884504 13.25766741 0.000271467 0.009212888 -4.270823533 0.896815901 14.82945756 0.000117683 0.004673836 -0.731312006 6.322024497 12.11864693 0.000499201 0.014718845 -1.104313241 5.293686638 12.63161173 0.000379278 0.011899654 -4.763395042 3.561867271 23.64688558 1.15733E-06 0.000121442 -5.348553154 6.108427694 33.33451187 7.75933E-09 2.82357E-06 -1.362988917 5.702221749 13.89920493 0.00019288 0.007039974 -2.339677827 -0.842974241 9.407920149 0.002160502 0.045038148 1.195044397 6.71741398 16.86877661 4.00551E-05 0.001942461 -1.985865886 -0.404713406 9.918648343 0.001636125 0.036282202 -1.105357374 4.970843694 13.70054282 0.000214393 0.007627076 -3.502622559 -1.192727512 14.72672413 0.000124272 0.004862186 -2.352562709 0.639807346 12.97812355 0.000315152 0.010333834

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

-2.280563038 8.329821505 46.97793175 7.17905E-12 8.26847E-09 -1.74879672 5.61618552 21.74524637 3.1136E-06 0.0002632 -3.456631263 0.033404195 18.95273151 1.33997E-05 0.000839306 -1.870557575 1.934814155 9.808018578 0.001737526 0.038118012 -4.84640155 3.42723278 25.17943309 5.22363E-07 6.63869E-05 -4.356852299 1.741811047 17.39314452 3.0392E-05 0.001586584 -1.724085474 4.497704159 17.7997519 2.45415E-05 0.001358365 -1.61087517 5.912761931 24.21212737 8.62872E-07 9.74173E-05 -1.132650876 7.028218372 16.41442095 5.08965E-05 0.002356586 -2.460599313 4.751788265 13.35425606 0.000257837 0.008914478 -2.185212747 -0.831022068 11.65321524 0.000640917 0.017707364 -2.471783753 6.487261771 13.72395801 0.000211736 0.007561773 -2.268963101 1.344245871 19.48066137 1.01623E-05 0.000666733 -3.076048219 4.59073839 36.88175125 1.25515E-09 6.60856E-07 -2.638757146 3.902311726 24.98685707 5.77224E-07 7.23612E-05 -2.886522381 5.403661998 28.27611389 1.05186E-07 1.98668E-05 -3.380573585 6.949792634 24.12676272 9.0198E-07 9.95311E-05 -1.673528074 -0.001327941 9.769737936 0.001774077 0.03855271 -4.482753167 2.574449491 26.98567093 2.04969E-07 3.34263E-05 -5.235435344 -0.917360953 17.6311217 2.68164E-05 0.001444949 -4.177221162 2.317376666 28.51687144 9.28856E-08 1.89804E-05 -4.635755023 1.563776477 21.78224235 3.05414E-06 0.000261775 -2.846264836 2.731908844 14.1683807 0.000167156 0.006262348 -2.321743792 0.376382429 14.98395672 0.000108429 0.004362733 -3.568921797 0.383738767 16.91503209 3.90908E-05 0.001920974 -2.04418128 1.461678926 19.52164201 9.94664E-06 0.00065934 1.2642263 5.158616962 10.10303372 0.001480254 0.033552434 -1.633465546 3.69702795 10.59340377 0.001134918 0.027664387 -1.489788171 5.731848363 26.31325399 2.9029E-07 4.2456E-05 -2.819799099 4.607596915 28.12543589 1.13702E-07 2.03427E-05 -2.297429574 -1.000143602 11.20248092 0.00081688 0.021322199 -1.743600168 4.81020168 9.839019065 0.001708486 0.037570378 -3.826103491 4.717091168 29.59567919 5.32234E-08 1.226E-05 -2.017305016 1.51614073 11.08543991 0.000870082 0.022487892 2.23856229 2.80712088 12.46401509 0.000414867 0.012699623 -1.176830812 4.239485122 10.2734258 0.0013496 0.031561452 -2.125733054 3.807905693 10.63253123 0.001111155 0.027338275 -4.190059222 3.06411167 22.76580365 1.82993E-06 0.000173825 -1.419995714 5.64494208 20.25598974 6.7741E-06 0.000477859 1.566061308 2.294317314 10.2973125 0.001332241 0.031274568 -4.62987833 -1.372927157 16.31726795 5.35735E-05 0.002455853 -2.954992188 -0.146148142 18.84265186 1.41957E-05 0.000883778 -1.699565499 2.092788019 10.29750867 0.001332099 0.031274568 -3.822947297 -1.92698469 11.21760967 0.000810248 0.021179076 -1.824940245 1.738496398 11.78589993 0.00059681 0.016816546 -4.691187147 1.814727783 35.22884804 2.93149E-09 1.28623E-06 -1.738843722 6.80848738 38.15293506 6.54113E-10 3.76687E-07 -2.832042981 -0.23106924 18.3650633 1.82371E-05 0.00107716 -3.749487957 2.364842581 20.44535848 6.13582E-06 0.000439964 -3.551650265 4.271982455 22.80964713 1.78866E-06 0.000170784

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

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Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

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Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

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Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

-4.863230339 0.483583082 36.12434225 1.8512E-09 8.52847E-07 -5.464640251 -2.213743451 10.24220746 0.001372632 0.031697829 5.803780018 -2.05176965 11.75996437 0.000605184 0.016949649 -4.551337133 -1.428097115 16.98355348 3.7705E-05 0.001867817 -6.038602506 -1.781942217 17.12347116 3.50268E-05 0.001763588 -3.883953895 -1.893238198 10.000152 0.001565273 0.035176649 -6.19856154 -1.675281095 19.65075691 9.29665E-06 0.000622977 -2.590613488 7.079131303 20.24858817 6.80036E-06 0.000477859 -4.126828112 3.856244375 34.35141885 4.60065E-09 1.88402E-06 -1.842744685 8.838487548 18.09567231 2.10078E-05 0.001202275 -2.114362637 0.594181339 11.56870494 0.000670711 0.018310911 -3.749649479 -1.411477965 12.53634002 0.000399113 0.012278564 -5.559254107 1.389604295 34.99616499 3.30355E-09 1.41576E-06 -4.288142457 -1.009885302 22.94893717 1.66362E-06 0.000162208 -3.304460822 -0.826995246 10.36032192 0.001287528 0.030564154 -9.067552346 0.756876785 25.75974508 3.8667E-07 5.20113E-05 -3.521415959 0.469262407 23.58190308 1.19708E-06 0.000124161 -5.600051728 0.098780379 40.9971122 1.52454E-10 1.14824E-07 -2.305146867 -0.625658787 9.911229127 0.001642734 0.036298097 -6.216180135 -1.627356836 11.08269803 0.000871369 0.022489626 -4.03131353 -0.799011235 18.94760042 1.34358E-05 0.000839306 -5.208029874 2.540770149 21.98031797 2.75461E-06 0.000244048 -2.697306665 0.847663422 12.2540944 0.000464238 0.013865454 -4.363868117 -1.605139062 14.82074406 0.000118228 0.004685382 -4.930055888 2.347722757 24.60970221 7.01974E-07 8.35139E-05 -2.14911242 3.059050077 14.14781937 0.000168993 0.00627863 -5.028567014 0.381301173 28.27888578 1.05035E-07 1.98668E-05 -4.915066757 -0.066544409 24.94878604 5.88736E-07 7.33056E-05 -4.134983648 1.368636939 20.84393381 4.98268E-06 0.000371744 1.113910048 4.262386968 13.31438214 0.000263378 0.009026966 0.907696185 5.478453252 17.51332074 2.85302E-05 0.001515141 2.081041494 0.098424642 17.34814044 3.11203E-05 0.001607273 1.778169603 0.455671178 11.47526673 0.000705285 0.01911323 -5.944816974 -1.873547885 19.12798623 1.22239E-05 0.000790395 -2.773786344 0.788541119 12.64961238 0.000375644 0.0118129 -2.234619627 3.578522801 10.99281676 0.000914657 0.023216664 -3.644501569 -2.051991758 10.43791851 0.001234543 0.029430998 -1.372205234 3.411579506 12.14239269 0.000492885 0.014579269 -1.599804783 4.583599055 9.293309758 0.002299922 0.047519462 -4.371753687 -0.177326023 17.65812764 2.64383E-05 0.001435423 4.880883937 -2.557886334 10.67290179 0.001087164 0.026904142 -3.076558014 -0.13176957 13.99393459 0.000183401 0.006745947 -2.826802696 -0.218228972 11.1161668 0.000855785 0.022180591 -4.102653992 0.62129121 18.74247016 1.49613E-05 0.000922096 -5.042734823 -2.401691263 11.37260583 0.000745352 0.019763098 1.819415806 2.546855313 17.79369187 2.46198E-05 0.001358365 -1.793197363 -0.621061028 10.63779224 0.001107999 0.027297058 -5.706374383 -2.036352315 12.14651962 0.000491796 0.014570431 -2.999471003 -0.479168133 22.6652759 1.92821E-06 0.000180371 -5.242110473 -2.292399627 12.25052976 0.000465126 0.013869488

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Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

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Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782 Supplementary material Ann Rheum Dis

-5.051569677 -2.399402958 11.14166141 0.000844103 0.021939523 -3.740076252 -1.428323638 10.52291977 0.001179031 0.028364458 -4.098240484 -1.145490117 14.77414581 0.000121186 0.004782034 -5.520150782 0.027451938 28.71604017 8.38067E-08 1.73527E-05 -2.685334082 -0.717242919 12.99438377 0.000312427 0.010262742 -3.522774007 -1.567184271 13.10544601 0.000294439 0.009811779 2.783619357 -1.848180163 9.293120063 0.002300161 0.047519462 -5.168935277 -2.341399373 13.19363417 0.000280902 0.009429759 -4.460083257 0.163696283 26.70668513 2.36801E-07 3.68948E-05

Grigoriou M, et al. Ann Rheum Dis 2019;0:1–12. doi: 10.1136/annrheumdis-2019-215782