Somnology Part One with Dr. W. Chris Winter Ologies Podcast October 15, 2018
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Sleep and Its Disorders: Is the Problem
38 ISSN 0049-6804. «Врачеб. дело». 2017, № 1–2 ОБЗОР ЛИТЕРАТУРЫ 43. Williams G. R., Duncan Bassett J. H. Local control of thyroid hormone action: role of type 2 deiodinase Deiodinases: the balance of thyroid hormone // J. of Endocrinol. – 2011. – Vol. 209. – P. 261–272. 44. Wittmann G., Harney J. W., Singru P. S. et al. Inflammation-inducible type 2 deiodinase expres- sion in the leptomeninges, choroid plexus, and at brain blood vessels in male rodents // Endocri- nology. – 2014. – Vol. 155. – P. 2009–2019. 45. Yu J., Koenig R. J. Induction of type 1 iodothyronine deiodinase to prevent the nonthyroidal illness syndrome in mice // Endocrinol. – 2006. – Vol. 147, N 7. – Р. 3580–3585. СУЧАСНІ УЯВЛЕННЯ ПРО СИНДРОМ НЕТИРЕОЇДНОЇ ПАТОЛОГІЇ В КЛІНІЧНІЙ ПРАКТИЦІ Н. О. Абрамова, Н. В. Пашковська (Чернівці) Будь-які гострі та хронічні захворювання, що втягують у патологічний процес весь організм, можуть викликати порушення обміну тиреоїдних гормонів на фоні відсутності супутньої патології щитоподібної залози, гіпофіза та (або) гіпоталамуса. Такі порушення називають «син- дромом нетиреоїдної патології» (СНТП), або «синдромом низького Т3», і зустрічаються у 70 % госпіталізованих. У даному огляді ми розглянули етіологію, патогенез та частково шляхи корекції синдрому нетиреоїдної патології. Ключові слова: синдром нетиреоїдної патології, синдром низького Т3, порушення обміну тиреоїдних гормонів. CURRENT VIEWS ON NONTHYROIDAL ILLNESS SYNDROME IN CLINICAL PRACTICE (REVIEW) N. O. Abramova, N. V. Pashkovska (Chernivtsi, Ukraine) Higher State Educational Establishment of Ukraine «Bukovinian State Medical University» Any acute and chronic diseases that involve the whole organism into pathological process, can cause violation of thyroid hormones metabolism against a background of absence of concomitant diseases of thyroid gland, pituitary gland or hypothalamus. -
Pop Culture, Including at the Stateof Race in of Catch-Up? Gqlooks Just Playing Aslow Game Narrowing, Or Are We Racial Gapinhollywood Lena Dunham
THE > Pop Culture: Now in Living Color #oscarssowhite. Whitewashing. Lena Dunham. Is the racial gap in Hollywood narrowing, or are we just playing a slow game of catch-up? GQ looks at the state of race in pop culture, including JORDAN PEELE’S new racially tense horror movie, the not-so-woke trend of actors playing other ethnicities, and just how funny (or scary) it is to make fun of white people STYLIST: MICHAEL NASH. PROP STYLIST: FAETHGRUPPE. GROOMING: HEE SOO SOO HEE GROOMING: FAETHGRUPPE. STYLIST: PROP NASH. MICHAEL STYLIST: KLEIN. CALVIN TIE: AND SHIRT, SUIT, GOETZ. + MALIN FOR KWON PETER YANG MARCH 2017 GQ. COM 81 THEPUNCHLIST Jordan Peele Is Terrifying The Key & Peele star goes solo with a real horror story: being black in America jordan peele’s directorial debut, Get Out, is the story of a black man who visits the family of his white girlfriend and begins to suspect they’re either a little racist or plotting to annihilate him. Peele examined race for laughs on the Emmy-winning series Key & Peele. But Get Out expresses racial tension in a way we’ve never seen before: as the monster in a horror Why do you think that is? the layer of race that enriches flick. caity weaver EGG ON YOUR talked to Peele in his Black creators have not been and complicates that tension given a platform, and the [in Get Out] becomes relatable. (BLACK)FACE editing studio about African-American experience An index of racially using race as fodder for can only be dealt with by My dad is a black guy from questionable role-playing a popcorn thriller and an African-American. -
Table of Contents 67
Table Of Contents 67 . Hagspawn Hag Options 68 . Hagspawn Brute 2 . Elder Hags 68 . Hagspawn Mage 3 . Hag Magic 69 . Hagspawn Thug 3 . Hag Curses 70 . Jack o' Lantern 4 . Transformations 71 . Jermlaine 4 . Familiars 72 . Kenku Mage 4 . Animal Affinities 73 . Leech Toad 4 . Hag Alchemy 74 . Libation Oozes 7 . Hag Items 74 . Amber Ale 11 . Weird Magic 75 . Golden Champagne 15 . Hag Weaknesses 75 . Ebony Lager 16 . Non-Evil Hags 75 . Ivory Moonshine 17 . Covens 77 . Perfumed Liqueur 17 . Coven Challenge Ratings 77 . Ruby Merlot 18 . Elder Covens 78 . Moor Hound 18 . New Coven Types 79 . Quablyn 19 . Non-Evil Covens 80 . Scarecrow 19 . Coven Items 80 . Effigy Scarecrows 21 . Unique Covens 80 . Guardian Scarecrows 80 . Infernal Scarecrow New Hags 80 . Pestilence Scarecrows 27 . Carey Hag 81 . Shadow Asp 29 . Deemves Hag 82 . Sporeback Toad 31 . Deep Hag 82 . Stirge Swarm 33 . Dusk Hag 83 . Stitched Devil 35 . Fanggen Hag 84 . Styrix 38 . Hocus Hag 85 . Wastrel 40 . Marzanna Hag 42 . Mojan Hag Unique Hags 44 . Powler Hag 86 . Baba Yaga, Mother of All Witches 46 . Sighing Hag 87 . Baba Yaga's Dancing Hut 87 . The Solar Knight Hag Related Creatures 90 . Black Agga, the Voice of Vaprak 49 . Animated Objects 93 . Cegilune, the Moon Crone 49 . Dancing Cauldron 96 . Yaya Zhelamiss 50 . Flying Spoon 98 . Ceithlenn, of the Crooked Teeth 50 . Swarm of Cutlery 101 . Malagard, the Hag Countess 50 . Ash Rat 106 . Kalabon 52 . Assassin Devil (Dogai) 53 . Boglin 54 . Broodswarm 55 . Cait Sith 56 . Canomorph 56 . Haraknin 57 . Shadurakul 58 . Yeshbavhan 59 . Catobleopas Harbinger 60 . -
Notre Dame Scholastic, Vol. 102, No. 11
a c/> c/> The most famous names in American men's wear are here for you: Eagle, Society Brand, GGG, Hickey-Freeman, Burberry, Alligator, 'Botany' 500, Alpagora, Arrow, Hathaway, Swank, McGregor, Bemhard Altmann, Dobbs, Florsheim . and many, many more. Truly the finest men's clothing and furnishings ob tainable in today's world markets. On the Cmnfius—Notre Drnne o &&& ... so select what you need now: a new suit or topcoat for the holidays ahead . gifts for special friends, and charge them the Campus Shop way. By the way, the Campus Shop will give you quick, expert fitting service so that what you purchase now will be altered and ready before. you leave the campus for the holidays. Merry Christmas and Happy New Year! CHARGE IT THE CAMPUS SHOP WAY 1/3 1/3 IN JUNE IN JULY No Carrying Charge ^ILBERrS On the Campus—Notre Dune Kttfa QaCampis MsShoIman (Author of "I Was a Teen-age Dwarf", "The Manii Loves of Dobie Gillis", etc.) DECK THE HALLS The time has come to make out our Robespierre, alas, was murdered quicker Inarticulate Society Christmas shopping lists, for Christmas than 3'ou could shout Jacques Robes Editor: %\-iU be upon us quicker than you can saj' pierre (or Jack Robinson as he is called Mr. Hudson, in last w^eek's Reper cussions, took issue with Mr. Smith's Jack Robinson. (Have j'ou ever won in the English-speaking countries). hierarchical theory of government: it dered, incidentall}--, about the origin of (There is, I am pleased to report, one was Mr. -
Sleepiness the Wheel
SLEEPINESS AT THE WHEEL WHITE PAPER SLEEPINESS AT THE WHEEL WHITE PAPER Sleepiness at the Wheel WHITE PAPER PREFACE Improving road safety is a priority of the French Government. Among the various causes of road accidents, one of them is especially common on motorways: lack of alertness, which leads to inattention and sleepiness. Lack of alertness is responsible for one in three collisions resulting in deaths on the motorway network, although it is the safest of all road networks! This phenomenon is not fully grasped by the public. Therefore, it is essential to gain knowledge and raise the publics’ awareness as regards sleepiness at the wheel. In more general terms, sleepiness at the wheel remains underestimated both socially and culturally speaking, which is a major issue for road safety and public health. This white book, put together by the French Motorway Companies (ASFA) and the National Institute of Sleep and Vigilance (INSV), presents the most recent knowledge on the subject at both the French and European levels and provides a number of recommendations. By contributing to a better understanding of sleepiness at the wheel, this work will help promote the implementation of new prevention strategies, to further reduce the number of victims on the road. Our objective is to cut down to less than 2000 the number of deaths per year on French roads by 2020. Manuel VALLS French Minister of Interior ASFA and INSV would like to express their deep thanks to the panel of European sleep experts who author this book. Most of them also participate in the research on traffic accidents associated with sleepiness in their own country and thus have contributed to enrich our knowledge and proposals for preventing from the consequences of sleepiness at the wheel. -
De-Demonising the Old Testament
De-Demonising the Old Testament An Investigation of Azazel , Lilith , Deber , Qeteb and Reshef in the Hebrew Bible Judit M. Blair Doctor of Philosophy University of Edinburgh 2008 Declaration I declare that the present thesis has been composed by me, that it represents my own research, and that it has not been submitted for any other degree or professional qualification. ______________________ Judit M. Blair ii ACKNOWLEDGEMENTS There are many people to thank and acknowledge for their support and help over the past years. Firstly I would like to thank the School of Divinity for the scholarship and the opportunity they provided me in being able to do this PhD. I would like to thank my ‘numerous’ supervisors who have given of their time, energy and knowledge in making this thesis possible: To Professor Hans Barstad for his patience, advice and guiding hand, in particular for his ‘adopting’ me as his own. For his understanding and help with German I am most grateful. To Dr Peter Hayman for giving of his own time to help me in learning Hebrew, then accepting me to study for a PhD, and in particular for his attention to detail. To Professor Nick Wyatt who supervised my Masters and PhD before his retirement for his advice and support. I would also like to thank the staff at New College Library for their assistance at all times, and Dr Jessie Paterson and Bronwen Currie for computer support. My fellow colleagues have provided feedback and helpful criticism and I would especially like to thank all members of HOTS-lite I have known over the years. -
Sleep, Its Attributes, Deprivation & Hygiene: a Recapitulation
Review Article Annals of Sleep Medicine Research Published: 21 Jun, 2019 Sleep, Its Attributes, Deprivation & Hygiene: A Recapitulation Priyanka Malhotra* Nursing in Mental Health Nursing From PGIMER, Chandigarh, India Presently working as Nursing Tutor, AIIMS, Rishikesh, India Abstract Sleep is a biological and behavioral phenomenon that has been studied from many different perspectives. Today it is clear that sleep quantity and quality is related to the development of chronic diseases and even mental disorders. However, many people ignore their sleep habits and fail to take active steps to adopt sleep hygiene practices preferring instead to relay on non-prescribed or prescribed pharmacological products. As a result of the potential consequences of sleep deprivation, health care professionals should be vigilant of how managing underlying medical conditions may help to optimize sleep continuity and consider prescribing interventions that minimize sleep disruption. Keywords: Sleep; Sleep deprivation; Sleep hygiene Introduction Almost every night we are engaging ourselves in a sound sleep. However, pattern of sleep and its features vary from person to person. Various body functions such as metabolism, appetite, cardiovascular system, and immune system has been maintained and regulated by sleep. Hence, for the optimum level of health, sleep is an important factor [1,2]. Sleep is a state of reduced consciousness that is relatively easy to reverse. A normal healthy sleep is distinguish by good quality, appropriate time and regularity, enough duration and without any sleep disorder and disturbance [3]. Attributes of Normal Sleep OPEN ACCESS The stages of sleep have historically been divided into one stage of Rapid Eye Movement (REM) sleep and four stages (Stages 1-4) of Non-Rapid Eye Movement (NREM) sleep that are characterized *Correspondence: by increasing sleep depth. -
Polymorphism Located in TCRA Locus Confers Susceptibility to Essential Hypersomnia with HLA-DRB1&Ast;1501-DQB1&Ast;0602
Journal of Human Genetics (2010) 55, 63–65 & 2010 The Japan Society of Human Genetics All rights reserved 1434-5161/10 $32.00 www.nature.com/jhg SHORT COMMUNICATION Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype Taku Miyagawa1, Makoto Honda2,3, Minae Kawashima1,4, Mihoko Shimada1, Susumu Tanaka2, Yutaka Honda3 and Katsushi Tokunaga1 Essential hypersomnia (EHS) exhibits excessive daytime sleepiness without cataplexy and is associated with the HLA-DRB1*1501-DQB1*0602 haplotype, similar to narcolepsy with cataplexy. Single-nucleotide polymorphism (SNP) rs1154155 located in the T-cell receptor a (TCRA) locus has been recently identified as a novel genetic marker of susceptibility for narcolepsy with cataplexy. We investigated whether the SNP was associated with EHS in the Japanese population. We found a significant association with EHS patients possessing the HLA-DRB1*1501-DQB1*0602 haplotype, compared À4 with HLA-matched healthy individuals (Pallele¼0.008; Ppositivity¼5Â10 ), whereas no significant association was observed for EHS patients without this haplotype. Thus, TCRA is a plausible candidate for susceptibility to EHS patients positive for the HLA-DRB1*1501-DQB1*0602 haplotype. Journal of Human Genetics (2010) 55, 63–65; doi:10.1038/jhg.2009.118; published online 20 November 2009 Keywords: essential hypersomnia; HLA; narcolepsy; TCRA INTRODUCTION possible association between SNP rs1154155 in the TCRA locus and Earlier studies have revealed that narcolepsy with cataplexy is asso- essential hypersomnia (EHS), CNS hypersomnia similar to narcolepsy ciated with the human leukocyte antigen (HLA) and T-cell receptor a with cataplexy, with regard to the symptom of excessive daytime (TCRA) genes. -
Sleep Disorders and Sleep Deprivation: an Unmet Public Health Problem
REPORT BRIEF • APRIL 2006 SLEEP DISORDERS AND SLEEP DEPRIVATION: AN UNMET PUBLIC HEALTH PROBLEM It is estimated that 50 to 70 million Americans chronically suffer from a disorder of sleep and wakefulness, hindering daily functioning and adversely affecting their health and longevity. The cumulative effects of sleep loss and sleep disorders represent an under-recognized public health problem and have been associated with a wide range of health consequences including an increased risk of hypertension, diabetes, obesity, depression, heart attack, and stroke. Almost 20 percent of all serious car crash injuries in the general population are associated with driver sleepiness. Hundreds of billions of dollars a year are spent on direct medical costs related to sleep disorders such as doctor visits, hospital services, prescriptions, and over-the-counter medications. Recognizing the health consequences of sleep disorders and sleep deprivation, the American Academy of Sleep Medicine, the National Center on Sleep Disorders Research at the National Institutes of Health, the National Sleep Foundation, and the Sleep Research Society The cumulative requested that the Institute of Medicine review the public health effects of sleep loss significance of sleep, sleep loss, and sleep disorders; examine gaps and sleep disorders in research, education, and training in the public health system and academia; and provide a comprehensive plan for enhancing sleep represent an under- medicine and research. recognized public Sleep Disorders and Sleep Deprivation: An Unmet Public Health health problem and Problem concluded that although scientific opportunities and clinical have been associat- activities in the field are expanding, the available human resources and ed with a wide infrastructural capacity to improve patient care and expand scientific range of health research are insufficient. -
Sleep Disturbance in MS
SLEEP DISTURBANCE AND MULTIPLE SCLEROSIS Abbey J. Hughes, PhD Department of Rehabilitation Medicine University of Washington School of Medicine Table of Contents Introduction ................................................................................................................................................................ 2 Summary of MS Sleep Research .......................................................................................................................... 3 Emerging Treatments for Sleep Disturbance in MS .................................................................................... 6 Tips for Assessing Your Sleep – Worksheet .................................................................................................. 8 Additional Tools and Resources.......................................................................................................................... 9 References ................................................................................................................................................................ 10 1 Introduction Multiple sclerosis (MS) is a chronic disease characterized by loss of myelin (demyelination) and damage to nerve fibers (neurodegeneration) in the central nervous system (CNS). MS is associated with a diverse range of physical, cognitive, emotional, and behavioral symptoms, and can significantly interfere with daily functioning and overall quality of life. MS directly impacts the CNS by causing demyelinating lesions, or plaques, in the brain, -
Cognitive Behavioral Therapy for Insomnia Enhances Depression Outcome in Patients with Comorbid Major Depressive Disorder and Insomnia
INSOMNIA AND DEPRESSION Cognitive Behavioral Therapy for Insomnia Enhances Depression Outcome in Patients with Comorbid Major Depressive Disorder and Insomnia Rachel Manber, PhD1; Jack D. Edinger, PhD2; Jenna L. Gress, BA1; Melanie G. San Pedro-Salcedo, MA1; Tracy F. Kuo, PhD1; Tasha Kalista, MA1 1Stanford University, Stanford, CA; 2VA Medical Center and Duke University Medical Center, Durham, NC Study Objective: Insomnia impacts the course of major depressive severity index (ISI), daily sleep diaries, and actigraphy. disorder (MDD), hinders response to treatment, and increases risk for EsCIT + CBTI resulted in a higher rate of remission of depression depressive relapse. This study is an initial evaluation of adding cogni- (61.5%) than EsCIT + CTRL (33.3%). EsCIT + CBTI was also associat- tive behavioral therapy for insomnia (CBTI) to the antidepressant medi- ed with a greater remission from insomnia (50.0%) than EsCIT + CTRL cation escitalopram (EsCIT) in individuals with both disorders. (7.7%) and larger improvement in all diary and actigraphy measures of Design and setting: A randomized, controlled, pilot study in a single sleep, except for total sleep time. academic medical center. Conclusion: This pilot study provides evidence that augmenting an Participants: 30 individuals (61% female, mean age 35±18) with MDD antidepressant medication with a brief, symptom focused, cognitive- and insomnia. behavioral therapy for insomnia is promising for individuals with MDD Interventions: EsCIT and 7 individual therapy sessions of CBTI or and comorbid insomnia in terms of alleviating both depression and in- CTRL (quasi-desensitization). somnia. Measurements and results: Depression was assessed with the Keywords: Major depressive disorder, Insomnia, Cognitive behavioral HRSD17 and the depression portion of the SCID, administered by raters therapy, Remission masked to treatment assignment, at baseline and after 2, 4, 6, 8, and Citation: Manber R; Edinger JD; Gress JL; San Pedro-Salcedo MG; 12 weeks of treatment. -
Sleep and Mental Wellbeing Exploring the Links
Sleep and mental wellbeing Exploring the links Technical report prepared by Kate Bartel, Cele Richardson and Michael Gradisar vichealth.vic.gov.au © VicHealth 2018 April 2018 P-MW-604 Suggested citation Bartel, K, Richardson, C & Gradisar M 2018, Sleep and mental wellbeing: exploring the links, Victorian Health Promotion Foundation, Melbourne. Acknowledgements The authors are grateful for the helpful comments of Emeritus Professor Dorothy Bruck, Chair of the Sleep Health Foundation, on an earlier draft of this report. Contents Acknowledgements ................................................................................................................................... i Key definitions .......................................................................................................................................... v Abbreviations ......................................................................................................................................... vii Executive summary ............................................................................................................................... viii Australian sleep patterns .................................................................................................................. viii Sleep and mental health.................................................................................................................... viii Lifestyle factors associated with sleep .............................................................................................