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Mechanisms & Models of Cancer Abstracts of papers presented at the 2010 meeting on MECHANISMS & MODELS OF CANCER August 17–August 21, 2010 View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Cold Spring Harbor Laboratory Institutional Repository Cold Spring Harbor Laboratory Cold Spring Harbor, New York Abstracts of papers presented at the 2010 meeting on MECHANISMS & MODELS OF CANCER August 17–August 21, 2010 Arranged by Dafna Bar-Sagi, New York University Medical Center Jacqueline Lees, MIT Center for Cancer Research Charles Sherr, HHMI/St. Jude Children's Research Hospital William Weiss, University of California, San Francisco Cold Spring Harbor Laboratory Cold Spring Harbor, New York This meeting was funded in part by the National Cancer Institute, a branch of the National Institutes of Health; and Merck Research Laboratories. Contributions from the following companies provide core support for the Cold Spring Harbor meetings program. Corporate Sponsors Agilent Technologies AstraZeneca BioVentures, Inc. Bristol-Myers Squibb Company Genentech, Inc. GlaxoSmithKline Hoffmann-La Roche Inc. Life Technologies (Invitrogen & Applied Biosystems) Merck (Schering-Plough) Research Laboratories New England BioLabs, Inc. OSI Pharmaceuticals, Inc. Sanofi-Aventis Plant Corporate Associates Monsanto Company Pioneer Hi-Bred International, Inc. Foundations Hudson-Alpha Institute for Biotechnology Front cover: Photographs and design by Constance Brukin. MECHANISMS & MODELS OF CANCER Tuesday, August 17 – Saturday, August 21, 2010 Tuesday 7:30 pm Keynote Speaker 1 Apoptosis and Autophage Wednesday 9:00 am 2 Signaling Mechanisms I Wednesday 2:00 pm 3 Poster Session I Wednesday 4:30 pm Wine and Cheese Party * Wednesday 7:30 pm 4 Mouse Models Thursday 9:00 am 5 Rb and p53 Networks Thursday 2:00 pm 6 Poster Session II Thursday 7:30 pm 7 Microenvironment, Inflammation and Metastasis Friday 9:00 am 8 Experimental Therapeutics Friday 2:00 pm 9 Genomics, Proteomics, Epigenetics Friday 6:00 pm Banquet Saturday 9:00 am 10 Signaling Mechanisms II Poster sessions are located in Bush Lecture Hall * Airslie Lawn, weather permitting Mealtimes at Blackford Hall are as follows: Breakfast 7:30 am-9:00 am Lunch 11:30 am-1:30 pm Dinner 5:30 pm-7:00 pm Bar is open from 5:00 pm until late Abstracts are the responsibility of the author(s) and publication of an abstract does not imply endorsement by Cold Spring Harbor Laboratory of the studies reported in the abstract. These abstracts should not be cited in bibliographies. Material herein should be treated as personal communications and should be cited as such only with the consent of the author. Please note that recording of oral sessions by audio, video or still photography is strictly prohibited except with the advance permission of the author(s), the organizers, and Cold Spring Harbor Laboratory. Printed on 100% recycled paper. PROGRAM TUESDAY, August 17—7:30 PM SESSION 1 APOPTOSIS AND AUTOPHAGY Chairperson: E. White, Rutgers University, New Brunswick, New Jersey KEYNOTE SPEAKER Joan Brugge Harvard Medical School Eileen White. Presenter affiliation: Rutgers University, New Brunswick, New Jersey. Cyclopamine and the sonic hedgehog pathway in melanoma maintenance and chemoresistance Agnieszka Checinska, Fernando García, Keith Ashman, Maria Soengas. Presenter affiliation: CNIO Spanish National Cancer Research Centre, Madrid, Spain. 1 Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer Fabrizio d'Adda di Fagagna. Presenter affiliation: IFOM Foundation, Milan, Italy. 2 The pro-apoptotic function of the retinoblastoma tumor suppressor protein Alessandra Ianari, Tiziana Natale, Eliezer Calo, Elisabetta Ferretti, Edoardo Alesse, Isabella Screpanti, Kevin Haigis, Alberto Gulino, Jacqueline Lees. Presenter affiliation: MIT, Cambridge, Massachusetts; University of Rome, La Sapienza, Rome, Italy. 3 v Senescence surveillance suppresses carcinogenesis in the liver and involves an adaptive immune response against premalignant senescent hepatocytes Tae-Won Kang, Tetyana Yevsa, Norman Woller, Lisa Hoenicke, Torsten Wuestefeld, Thomas Longerich, Peter Schirmacher, Stefan Kubicka, Lars Zender. Presenter affiliation: Helmholtz Centre for Infection Research, Braunschweig, Germany; Hannover Medical School, Hannover, Germany. 4 Abrogation of oncogene-induced senescence by PI3K pathway activation contributes to human nevus-to-melanoma progression Liesbeth Vredeveld, Patricia Possik, Chrysiis Michaloglou, Wolter Mooi, Daniel Peeper. Presenter affiliation: Netherlands Cancer Institute, Amsterdam, the Netherlands. 5 Cdk2 inhibition delays Myc-driven leukemia in vivo through induction of cellular senescence Eduar Hejll, Per Hydbring, Kari Högstrand, Alf Grandien, Lars-Gunnar Larsson. Presenter affiliation: Karolinska Institutet, Stockholm, Sweden. 6 WEDNESDAY, August 18—9:00 AM SESSION 2 SIGNALING MECHANISMS I Chairperson: R. Shaw, The Salk Institute for Biological Studies, La Jolla, California Reuben Shaw. Presenter affiliation: The Salk Institute for Biological Studies, La Jolla, California. Mutant N-RAS activates MAPK and STAT3 from lipid rafts to suppress apoptosis—A new paradigm for functional specificity within the RAS oncoprotein family Kevin Haigis. Presenter affiliation: Massachusetts General Hospital, Charlestown, Massachusetts; Harvard Medical School, Boston, Massachusetts. 7 vi Distinct biological outputs of oncogenic N-Ras and K-Ras expression in the hematopoietic compartment Jin Xu, Kevin Shannon. Presenter affiliation: UCSF, San Francisco, California. 8 The 8p21.3 lung tumor suppressor DOK2 opposes oncogenic EGFR and KRAS Alice H. Berger, Alessandro Morotti, Katerina Politi, Justyna A. Janas, Masaru Niki, Barry S. Taylor, Cameron Brennan, Roderick T. Bronson, Marc Ladanyi, Linda Van Aelst, Harold E. Varmus, Pier Paolo Pandolfi. Presenter affiliation: Cancer Genetics Program, BIDMC, Boston, Massachusetts; Weill Graduate School, New York New York. 9 Ras oncogene-induced ROS detoxification promotes tumorigenesis Gina M. DeNicola, Florian A. Karreth, Cong Wei, Kristopher Frese, Dipti Mangal, Aarthi Gopinathan, Kenneth H. Yu, Charles J. Yeo, Eric S. Calhoun, Francesca Scrimieri, Jordan M. Winter, Ralph H. Hruban, Christine Iacobuzio-Donahue, Scott E. Kern, Ian A. Blair, David A. Tuveson. Presenter affiliation: Cancer Research UK, Cambridge, United Kingdom. 10 Tumour suppression by NRBP1 through regulation of the Wnt pathway Catherine H. Wilson, Gino B. Poulin, Catriona Crombie, Alistair G. Rust, Nikki H. March, George Poulogiannis, Mark J. Arends, Andy G. Fraser, David J. Adams. Presenter affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom. 11 Functional dissection of the Chr. 6q deletion reveals Ephrin signaling as a tumor suppressive mechanism in follicular lymphoma Elisa Oricchio, Gouri Nanjangud, Andrew L. Wolfe, Man Jiang, Wayne Tam, Hui Zhaoh, Adriana Heguy, Nickolas Socci, Adam Olshen, Raju Chaganti, Hans-Guido Wendel. Presenter affiliation: Memorial Sloan Kettering Cancer Center, New York, New York. 12 Aberrant expression of NF-κB inducing kinase underlies constitutive NF-κB activation in cancer cells Yasunori Saitoh, Shin Uota, Vicente Javier Martinez Bruyn, Atae Utsunomia, Toshiki Watanabe, Shoji Yamaoka. Presenter affiliation: Tokyo Medical and Dental University, Tokyo, Japan. 13 vii Telomere-driven tetraploidization and its relevance to cancer Teresa Davoli, Eros Lazzerini Denchi, Titia de Lange. Presenter affiliation: The Rockefeller University, New York, New York. 14 SATB2 augments ΔNp63α in head and neck squamous cell carcinoma Jacky Chung, Joanne Lau, Lynn Cheng, Ian Grant, Suzanne Kamel- Reid, Jason Moffat, Michael Ohh, Bayardo Perez-Ordonez, David Kaplan, Meredith Irwin. Presenter affiliation: University of Toronto, Toronto, Canada; Hospital for Sick Children Research Institute, Toronto, Canada. 15 WEDNESDAY, August 18—2:00 PM SESSION 3 POSTER SESSION I Structural rearrangements in genetically engineered mouse mammary tumors Christiaan Klijn, Ignatio Varela, Phillip J. Stevens, Hanneke van Gulden, Eva Schut, Lodewyk Wessels, Jos Jonkers, Andy Futreal, Mike R. Stratton, David J. Adams. Presenter affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom. 16 Characterization of the jumonji domain containing histone demethylase Jmjd2c in normal development and cancer Karl Agger, Marianne T. Pedersen, Gitte Andersen, Kristian Helin. Presenter affiliation: University of Copenhagen, Copenhagen, Denmark. 17 β-catenin activation synergises with ras activation to cause bladder cancer formation Imran Ahmad, Yan Liu, Makoto Mark Taketo, Xue-Ru Wu, Hing Y. Leung, Owen J. Sansom. Presenter affiliation: Beatson Institute for Cancer Research, Glasgow, United Kingdom. 18 SSeCKS/AKAP12 maintains cell cycle checkpoint controls that prevent oncogenesis by attenuating PKC activation Shin Akakura, Peter Nochajski, Lingqiu Gao, Paula Sotomayor, Sei-ichi Matsui, Irwin H. Gelman. Presenter affiliation: Roswell Park Cancer Institute, Buffalo, New York. 19 viii CONEXIC—An integrative approach to uncover drivers of cancer Uri David Akavia, Oren Litvin, Jessica Kim, Felix Sanchez-Garcia, Helen C. Causton, Eyal Mozes, Dylan Kotliar, Yossi Tzur, Levi A. Garraway, Dana Pe'er. Presenter affiliation: Columbia University, New York, New York. 20 The role of the transcription factor NR4A1 in mammary epithelial cell adhesion and migration Annika N. Alexopoulou, Maria Leao, Munro A. Neville, Parmjit S. Jat. Presenter affiliation: Ludwig Institute for Cancer
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