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Neuroforum Gesellschaft Neurowissenschaftlichen Organ Der Herausgegeben Von Herausgegeben 2018 · VOLUME 24 · ISSUE 1 ISSN 0947-0875 · e-ISSN 1868-856X NEUROFORUM 2018 · VOLUME 24 · ISSUE 1 · PP. 1 · PP. · ISSUE 24 · VOLUME 2018 NEUROFORUM ORGAN DER NEUROWISSENSCHAFTLICHEN GESELLSCHAFT – 1 72 HERAUSGEGEBEN VON Neurowissenschaftliche Gesellschaft e.V. (NWG) CHEFREDAKTEUR Heiko J. Luhmann, Mainz www.degruyter.com/journals/nf Offenlegung der Inhaber und Beteiligungsverhältnisse gem. § 7a Abs. 1 Ziff. 1, Abs. 2 Ziff. 3 des Berliner Pressegesetzes: Die Gesellschafter der Walter de Gruyter GmbH sind: Cram, Gisela, Rentnerin, Berlin; Cram, Elsbeth, Pensionärin, Rosengarten- Alvesen; Cram, Dr. Georg-Martin, Unternehmens-Systemberater, Stadtbergen; Cram, Maike, Wien (Österreich); Cram, Jens, Mannheim; Cram, Ingrid, Betriebsleiterin, Tuxpan/Michoacan (Mexiko); Cram, Sabina, Mexico, DF (Mexiko); Cram, Silke, Wissenschaftlerin, Mexico DF (Mexiko); Cram, Björn, Aachen; Cram, Berit, Hamm; Cram-Gomez, Susana, Mexico DF (Mexiko); Cram-Heydrich, Walter, Mexico DF (Mexico); Cram-Heydrich, Kurt, Angestellter, Mexico DF (Mexico); Duvenbeck, Birgitta, Oberstudienrätin i.R., Bad Homburg; Gädeke, Gudula, M.A., Atemtherapeutin/Lehrerin, Tübingen; Gädeke, Martin, Einzelunterneh- mer, Ingolstadt; Lubasch, Dr. Annette, Ärztin, Berlin; Schütz, Dr. Christa, Ärztin, Mannheim; Schütz, Sonja, Berlin; Schütz, Juliane, Berlin; Schütz, Antje, Berlin; Schütz, Valentin, Mannheim; Seils, Dorothee, Apothekerin, Stuttgart; Seils, Dr. Ernst-Albert, Pensionär, Reppenstedt; Seils, Gabriele, Dozentin, Berlin; Seils, Christoph, Journalist, Berlin; Siebert, John-Walter, Pfarrer, Oberstenfeld; Tran, Renate, Mediatorin, Zürich (Schweiz). NEUROFORUM HERAUSGEGEBEN VON Neurowissenschaftliche Gesellschaft e.V. (NWG) CHEFREDAKTEUR Heiko J. Luhmann, Mainz REDAKTION Susanne Hannig, Berlin REDAKTIONSGREMIUM Mathias Bähr, Göttingen Michael Heneka, Bonn Denise Manahan-Vaughan, Bochum Niels Birbaumer, Tübingen Anton Hermann, Salzburg, Österreich Thomas Möller, Cambridge, USA Alexander Borst, Martinsried Andreas Herz, München Ulrike Müller, Heidelberg Sebastian Brandner, London, US Isabella Heuser, Berlin Thomas Münte, Lübeck Katharina Braun, Magdeburg Sigismund Huck, Wien, Österreich Roger Nitsch, Zürich, Schweiz Nils Brose, Göttingen Mark Hübener, Martinsried Christian Pape, Münster Ansgar Büschges, Köln Reinhard Jahn, Göttingen Hans-Joachim Pflüger, Berlin Thomas Deller, Frankfurt/M. Peter Jonas, Klosterneuburg, Josef Rauschecker, Washington, USA Ricarda Diem, Heidelberg Österreich Angelika Richter, Leipzig Ulrich Dirnagl, Berlin Sabine Kastner, Princeton, USA Christine R. Rose, Düsseldorf Andreas Draguhn, Heidelberg Helmut Kettenmann, Berlin Stefan Rotter, Freiburg Jens Eilers, Leipzig Frank Kirchhoff, Homburg Susanne Schoch-McGovern, Bonn Herta Flor, Mannheim Christian Klämbt, Münster Rainer Schwarting, Marburg Eckhard Friauf, Kaiserslautern Thomas Klockgether, Bonn Mikael Simons, Göttingen Giovanni Galizia, Konstanz Matthias Kneussel, Hamburg Christian Steinhäuser, Bonn Magdalena Götz, München Michael Koch, Bremen Monika Stengl, Kassel Benedikt Grothe, München Arthur Konnerth, München Christiane Thiel, Oldenburg Sonja Grün, Jülich Sigrun Korsching, Köln Stefan Treue, Göttingen Onur Güntürkün, Bochum Kerstin Krieglstein, Freiburg Petra Wahle, Bochum Eckhart Gundelfinger, Magdeburg Trese Leinders-Zufall, Homburg Bernd Weber, Bonn Ileana Hanganu-Opatz, Hamburg Wolfgang Löscher, Hannover Christian Wegener, Würzburg Andreas Heinz, Berlin Siegrid Löwel, Göttingen Florentin Wörgötter, Göttingen Charlotte Helfrich-Förster, Würzburg Albert Christian Ludolph, Ulm Moritz Helmstädter, Frankfurt/M. Hanspeter A. Mallot, Tübingen ABSTRACTED/INDEXED IN Baidu Scholar · Case · CNKI Scholar (China National Knowledge Infrastructure) · CNPIEC · EBSCO Discovery Service · Elsevier: SCOPUS · Google Scholar · J-Gate · JournalGuide · JournalTOCs · KESLI-NDSL (Korean National Discovery for Science Leaders) · Microsoft Academic · Naviga (Softweco) · Primo Central (ExLibris) · Publons · ReadCube · SCImago (SJR) · Summon (Serials Solutions/ ProQuest) · TDNet · Ulrich's Periodicals Directory/ulrichsweb · WanFang Data · WorldCat (OCLC) ISSN 0947-0875 · e-ISSN 1868-856X Alle Informationen zur Zeitschrift, wie Hinweise für Autoren, Open Access, Bezugsbedingungen und Bestellformulare, sind online zu finden unter https://www.degruyter.com/view/j/nf HERAUSGEBER Neurowissenschaftliche Gesellschaft e.V. (NWG), Kontakt: Meino Alexandra Gibson, Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Straße 10, 13092 Berlin, Tel.: +49 (0)30 9406 3336, [email protected], www.nwg-info.de CHEFREDAKTEUR Prof. Dr. Heiko J. Luhmann, Institute of Physiology, University Medical Center, Duesbergweg 6, D-55128 Mainz (Germany), Tel.: +49 (0)6131 39 26070, http://physiologie.uni-mainz.de/physio/luhmann/index.htm REDAKTION Susanne Hannig, Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Str. 10, 13092 Berlin (Germany), Tel.: +49 (0)30 9406 3336, [email protected] JOURNAL MANAGER Torsten Krüger, De Gruyter, Genthiner Straße 13, 10785 Berlin, Germany. Tel.: +49 (0)30 260 05-173, Fax: +49 (0)30 260 05-250, E-Mail: [email protected] ANZEIGENVERANTWORTLICHE top-ad Bernd Beutel, Schlossergäßchen 10, 69469 Weinheim, Tel.: +49 (0)6201 290 92-0, Fax +49 (0)6201 290 92-20 20, [email protected] © 2018 Walter de Gruyter GmbH, Berlin/Boston COVER ILLUSTRATION Basierend auf der Abb. 2 in Kristine Krug und Andrew John Parker, Die neuronalen Signale, die Wahrnehmung verändern, Seite 39–48, in dieser Ausgabe SATZ fidus Publikations-Service GmbH, Nördlingen DRUCK Franz X. Stückle Druck und Verlag e.K., Ettenheim Printed in Germany VORSTAND DER AMTSPERIODE 2017–2019 PRÄSIDENT Kognitive Neurowissenschaften Eckhard Friauf, Kaiserslautern Hanspeter A. Mallot, Tübingen VIZEPRÄSIDENT Molekulare Neurobiologie Albert Christian Ludolph, Ulm Matthias Kneussel, Hamburg GENERALSEKRETÄR Neuropharmakologie/-toxikologie Christian Steinhäuser, Bonn Angelika Richter, Leipzig SCHATZMEISTER Systemneurobiologie Ansgar Büschges, Köln Benedikt Grothe, Martinsried SEKTIONSSPRECHER Verhaltensneurowissenschaften Computational Neuroscience Christian Wegener, Würzburg Stefan Rotter, Freiburg Zelluläre Neurowissenschaften Entwicklungsneurobiologie/Neurogenetik Christine R. Rose, Düsseldorf Petra Wahle, Bochum Klinische Neurowissenschaften Ricarda Diem, Heidelberg Neuroforum 2018 | Volume 24 | Issue 1 Inhalt Laura Busse Übersichtsartikel Der Einfluss von Fortbewegung auf die sensorische Informationsverarbeitung und die zugrunde liegenden Rosanna Parlato und Birgit Liss neuronalen Schaltkreise 49 Selektive Degeneration dopaminerger Neurone beim Parkinson-Syndrom: die zunehmende Rolle von Laura Busse veränderter Kalziumhomöostase und nukleolärer The influence of locomotion on sensory processing and Funktion 1 its underlying neuronal circuits A41 Rosanna Parlato and Birgit Liss Selective degeneration of dopamine neurons in Forschungsförderung Parkinson’s disease: emerging roles of altered calcium homeostasis and nucleolar function A1 Marco Prinz, Lena Geimer-Breitenstein und Josef Priller Sonderforschungsbereich (SFB/TRR 167) NeuroMac Sabine Windmann und Grit Hein „Entwicklung, Funktion und Potenzial von myeloischen Altruismus aus Sicht der Sozialen Zellen im zentralen Nervensystem“ 61 Neurowissenschaften 15 Sabine Windmann and Grit Hein Rezension Altruism from the Perspective of the Social Neurosciences A11 Michael Madeja/Joachim Müller-Jung (Hrsg.) Hirnforschung – was kann sie wirklich 67 Siegrid Löwel, Susanne Dehmel, Kalina Makowiecki und Evgenia Kalogeraki Lebensbedingungen haben einen starken Einfluss auf Nachrichten die Plastizität des Gehirns 25 Neue NWG-Website 69 Siegrid Löwel, Susanne Dehmel, Kalina Makowiecki and Evgenia Kalogeraki Bundesministerium für Bildung und Forschung Environmental conditions strongly affect brain fördert Aufbau eines Deutsch-Chinesischen plasticity A19 Fachnetzwerkes der Neurowissenschaften 70 Kristine Krug und Andrew John Parker Neueintritte 71 Die neuronalen Signale, die Wahrnehmung verändern 39 Ausblick/Preview 71 Kristine Krug and Andrew John Parker The neural events that change perception A31 Neuroforum 2018; 24(1): 1–14 Übersichtsartikel Rosanna Parlato und Birgit Liss* Selektive Degeneration dopaminerger Neurone beim Parkinson-Syndrom: die zunehmende Rolle von veränderter Kalziumhomöostase und nukleolärer Funktion https://doi.org/10.1515/nf-2017-0006 Einleitung Zusammenfassung: Morbus Parkinson (MP) ist die zweit- häufigste neurodegenerative Erkrankung. Die klassische Mit ungefähr 300.000 betroffenen Patienten allein in MP-Motorsymptomatik wird durch einen progressiven Deutschland ist Morbus Parkinson (MP) neben Morbus Dopaminverlust im Striatum verursacht, bzw. durch den Alzheimer die zweithäufigste neurodegenerative Erkran- fortschreitenden Verlust von Dopamin-ausschüttenden kung. Die Anzahl an Erkrankungen steigt mit hohem (DA) Neuronen im Mittelhirn (insbesondere in der Subs- Alter an (www.epda.eu.com). Die charakteristischen mo- tantia nigra, SN, auch schwarze Substanz genannt). Da die torischen Symptome des MP, passenderweise auch als Ursache für den MP immer noch unklar ist, stehen derzeit „Schüttellähmung“ bezeichnet, sind eine allgemeine keine kurativen Therapien zur Verfügung. Es konnten aber Minderbeweglichkeit (Bradykinesie, Akinesie), Rigor, pos- eine Reihe von genetischen und umweltbedingten Trigger- turale Instabilität und ein Ruhetremor. Diese sogenannten faktoren identifiziert werden, die auf einen gemeinsamen, Kardinalsymptome werden durch einen progredienten
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