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Using Big Science to Answer Big Questions

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2012 ANNUAL REPORT Using big science to answer big questions. 551 N 34th Street, Seattle, Washington 98103 alleninstitute.org | brain-map.org Back cover Front cover Our Team Founders Marc Tessier-Lavigne, Ph.D. David Tank, Ph.D. The Rockefeller University Princeton University Paul G. Allen David Van Essen, Ph.D. Giulio Tononi, M.D., Ph.D. Jody Allen Washington University University of Wisconsin, Madison Doris Tsao, Ph.D. California Institute of Technology Leadership Additional Scientific Advisors Christopher Walsh, M.D., Ph.D. Allan Jones, Ph.D. Harvard Medical School Chief Executive Officer Larry Abbott, Ph.D. Columbia University Chinh Dang Chief Technology Officer Yang Dan, Ph.D. Past Scientific Advisors University of California, Berkeley Christof Koch, Ph.D. Gregor Eichele, Ph.D. Chief Scientific Officer Michael Elowitz, Ph.D. Max Planck Institute for California Institute of Technology Biophysical Chemistry David Poston Chief Operating Officer Adrienne Fairhall, Ph.D. Eberhard Fetz, Ph.D. University of Washington University of Washington Anne Claude Gavin, Ph.D. Joshua Huang, Ph.D. Board of Directors European Molecular Cold Spring Harbor Laboratory Biology Laboratory Jody Allen Edward Jones, M.D., Ph.D. President and Board Chair, Richard Gibbs, Ph.D. University of California, Davis Allen Institute for Brain Science Baylor College of Medicine What makes us President and CEO, Vulcan Inc. Alexandra Joyner, Ph.D. Patrick Hof, M.D. New York University Nathaniel T. Brown Mount Sinai School of Medicine School of Medicine Senior Vice President, Finance and Financial Strategy, The Seattle Times Arnold Kriegstein, M.D., Ph.D. Sacha Nelson, M.D., Ph.D. University of California, University of California, San Diego Susan M. Coliton San Francisco human? Steven Paul, M.D. Vice President, Foundation and Collections, Vulcan Inc. John H.R. Maunsell, Ph.D. Weill Cornell Medical College Harvard Medical School The power of the human brain is unmatched even by Thomas Daniel, Ph.D. Luis Puelles, M.D., Ph.D. Professor of Biology, Neurobiology David McCormick, Ph.D. University of Murcia today’s most advanced computing technologies. Decoding Yale University and Behavior, Komen Endowed Larry Swanson, Ph.D. the brain’s mysteries is essential to understanding the Chair, University of Washington Markus Meister, Ph.D. University of Southern California Harvard University Stephen Hall Joseph Takahashi, Ph.D. human condition and to improving human health. Managing Director, Venture Randall Moon, Ph.D. University of Texas Southwestern Capital, Vulcan Inc. University of Washington Medical Center Allen D. Israel Jeffrey Nye, M.D., Ph.D. Arthur Toga, Ph.D. Member, Foster Pepper PLLC Janssen Pharmaceutical Companies University of California, Los Angeles of Johnson & Johnson Phyllis Wise, Ph.D. Pasko Rakic, M.D., Ph.D. University of Washington Scientific Advisory Board Yale School of Medicine David Anderson, Ph.D. Sharad Ramanathan, Ph.D. California Institute of Technology Harvard University Staff György Buzsáki, M.D., Ph.D. Botond Roska, M.D., Ph.D. More than 200 dedicated employees Rutgers University Friedrich Miescher Institute Approved 10-year for Biomedical Research More than 55 researchers plan for expansion and Edward Callaway, Ph.D. with Ph.D. degrees new scientific initiatives, Salk Institute for Biological Studies John Rubenstein, M.D., Ph.D. and received a new Thomas Daniel, Ph.D. University of California, $300M commitment from Published landmark University of Washington San Francisco Paul G. Allen to support study on the human brain Clifford Saper, M.D., Ph.D. Follow us on Twitter Phase I of the plan in Nature Catherine Dulac, Ph.D. @Allen_Institute Harvard University Harvard Medical School Daniel Geschwind, M.D., Ph.D. Eric Schadt, Ph.D. Like us on Facebook Mount Sinai School of Medicine Allen Institute for Brain Science Expanded scientific Generated ~1 petabyte University of California, Los Angeles leadership and team with of new data on the human Increased usage of the Lorenz Studer, M.D. Michael Stryker, Ph.D. Subscribe to us on YouTube 14 Ph.D.-level scientists brain, neural circuitry, Allen Brain Atlas resources Sloan-Kettering Institute University of California, AllenInstitute from Harvard, Stanford and brain development to more than 1 million San Francisco 2012 and other world-class for our online public visits from more than Karel Svoboda, Ph.D. institutions resources 125 countries Howard Hughes Medical Institute, Highlights Janelia Farm Research Campus Inside front cover Inside back cover We are dedicated to accelerating brain research, using How do we big science to drive the field forward. Our success enables scientists around the world to answer critical questions about the development, structure, and function of the brain, enable others? and to use those answers to improve human health. Our groundbreaking discoveries and research tools provide brain researchers around the world with truly innovative ways to ask and answer big questions in brain science. In 2004 we launched Since then, we have built With more than 4 million the first of our a highly valuable suite visits to date, our online “ The Allen Institute open public approach Allen Brain Atlas of publicly available, resources have supported is transforming brain that thousands of resources, forever web-based research tools many thousands of science around the scientists use to advance changing the way encompassing multiple experiments and are cited world. In the last their research every day. in which brain decade, the Institute I am excited to help the research could species, developmental routinely in peer-reviewed has successfully Institute build on these be conceptualized stages, anatomical struc- publications. Our sought-after tackled industrial- achievements and tures, and brain-related transgenic mouse lines are and conducted. scale science projects, expand the scale and Allan Jones, Ph.D. diseases. Any researcher also publicly available, and delivering massive scope of its impact.” Chief Executive Officer with an Internet connection we are generating additional databases with an can access these resources resources to support a freely through a single variety of laboratory and “ In 2012, we turned our focus data portal. Our tools computational studies from our achievements to enable scientists to work that have not previously date to the opportunities more quickly and make been feasible. that lie ahead. The launch more effective decisions, of our ambitious 10-year allowing them to focus plan sets us on a course on their most promising to further transform brain discoveries. research, both within our own walls and in collabo- ration with the global brain science community.” Paul G. Allen Founder Page 12 Page 1 ’03 ’04 ’05 ’06 ’07 ’08 >25,000 >250,000 visits to Allen visits to Allen Brain Atlas Brain Atlas resources resources (all 2005) (all 2008) Expense COMMUNITY Distribution 8% 10% 8% ALLEN Spinal Employees Cord Atlas created in response to Outside Services requests from the 3% Lab Supplies research commu- 12% nity and funded Depreciation by a consortium of Occupancy 8% contributors includ- Human Cortex ing foundations, Tools & Equipment Study, the Allen individuals, disease Other Institute’s first organizations, and 2012 human project ALLEN Mouse corporate entities. Sleep Study and a critical Brain Atlas [Completed 2009] [Completed 2008] foundation for [Completed 2006] generating the Allen Human Brain Atlas. [Completed 2009] ALLEN Developing ONLINE PUBLIC RESOURCES Mouse Brain Atlas [Completed 2010] Transgenic Mouse 51% Study Received $100M seed commitment from Paul G. Allen 9% 9% BUSINESS 8% Reached 100 Employees 2% Launched 16% operations 7% 2011 Where do we begin? 49% Page 2 Page 11 ’09 ’10 ’11 ’12 Financial Information >500,000 Held the >750,000 >1,000,000 visits to Allen First Annual visits to Allen visits to Allen Brain Atlas Allen Institute Brain Atlas Brain Atlas resources Symposium resources resources This new model of (all 2009) symposium engages top (all 2011) (all 2012) experts in discussions Allen Institute for Brain Science of diverse topics to stimulate collaborative First Allen Summary Statements of Financial Position As of December 31, and forward-thinking outlooks. Distribution Brain Atlas (in thousands) 2012 2011 of videos publicly Hackathon Current Assets online extends benefit brings programmers Cash and cash equivalents $ 18,267 $ 55, 1 1 5 to the global research and informatics experts Restricted cash 573 212 community. together to collaborate Federal grants receivable 1,217 406 on developing new data analysis strategies and Pledges receivable 47,000 100 tools based on the Allen Other current assets 2, 1 3 1 2,219 ALLEN Human Brain Atlas resources. Brain Atlas Total current assets 69,276 57,964 Mouse Diversity Study Restricted cash 1,082 1,073 [Completed 2009] Approval of Other non-current assets 400 Property and equipment, net 11,11 0 10,562 BrainSpan Atlas ALLEN Mouse 10-year plan of the Developing Brain Connectivity sets the course for Total assets $ 81,468 $ 69,999 Human Brain Atlas expanded opportunities NIH Blueprint and scientific endeavors. Non-Human New initiatives launched Current Liabilities Primate (NHP) in neural coding, Accounts payable $ 2,758 $ 1,580 Atlas molecular networks, Accrued expenses 1,479 1, 2 1 1 Ivy Glioblastoma and characterization of Atlas Project different brain cell types. Total liabilities 4,237 2,791 Net Assets Unrestricted 75,521 14,023 Reached 200 Temporarily restricted 1,710 53,185 Employees Received largest
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