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Biotechnology Training Retreat Fifteenth Annual Biotechnology Training Retreat Saturday, April 8, 2006 Christian Brothers Retreat & Conference Center Napa, CA Fifteenth Annual Biotechnology Training Retreat Saturday, April 8, 2006 Christian Brothers Retreat & Conference Center Napa, CA Co-sponsored by: NIH Training Program in Biomolecular Technology (NIH-1-T32-GM08799) UC Davis Designated Emphasis in Biotechnology Graduate Program (DEB) UC Davis Biotechnology Program Table of Contents Welcome 2 NIH Training Program in Biomolecular Technology 3 Designated Emphasis in Biotechnology, UC Davis 4 UC Davis Biotechnology Program 5 Retreat Agenda 6 2006 Poster Titles 7 Oral Presentations 9 Bioethics 25 Poster Abstracts 27 Company Affiliates 36 Training Retreat Participants 2006 46 Mission of UC Davis Biotechnology Program 51 NIH Training Grant Information 52 NIH Training Grant Faculty 53 NIH Training Program in Biomolecular Technology 55 Goals and Mission of Designated Emphasis in Biotechnology Progam 56 DEB Program Students as of March 2006 60 DEB Faculty Participants 63 The Value of Internships 66 Welcome On behalf of the UC Davis Biotechnology Program, the executive committees of the Designated Emphasis in Biotechnology (DEB) and the NIH Training Grant in Biomolecular Technology, we thank you for joining us as we honor our 2005-06 fellows and their preceptors, as well as our industry affiliates. We plan to have a day filled withgreat science, beautiful scenery and delicious food and wine. The logistics of this retreat has been graciously overseen by our assistant director, Carey Kopay and new event manager, Marianne Hunter. Please welcome our Biotechnology Fellows. Our 5 NIH Fellows include: Suzanne (Balko) Barber, Chemical Engineering major (preceptor is Tonya Kuhl); Allison Dickey, Chemical Engineering major (preceptor is Roland Faller); Corey Dodge, Chemical Engineering major (preceptor is Karen McDonald); Gian Oddone, Chemical Engineering major (preceptor is David Block) and Jennifer Warren, Civil and Environmental Engineering major (preceptor is Stefan Wuertz). Our 4 Biotechnology Fellows (industry and campus fellowships) include: Laura Higgins, Molecular, Cellular & Integrative Physiology major (preceptor is John “Jack” Rutledge); Vannarith “Van” Leang, Chemical Engineering major (preceptor is Robert “Bob” Powell); Riccardo LoCascio, Microbiology major (preceptor is David Mills) and Vu Bao Trinh, Biochemistry & Molecular Biology major (preceptor is Yohei Yokobayashi). We will be selecting our 2005-06 fellows in late May. Fellowship nominations are due on Monday, May 8, 2006. Forms are on the web at www.deb.ucdavis.edu). We would also like to recognize our First Year Biotechnology Fellows: Domink Green (Biochemistry and Molecular Biology); Connie Jen (Biochemistry and Molecular Biology) and Barbara Nellis (Chemical Engineering). Dominik and Connie have already become members of the DEB. Due to the limited time for oral presentations, we will showcase research performed by other students in the DEB program in the poster session. Please congratulate all of these outstanding predoctoral candidates. We are very proud of all of them. We are completing our fourth year of the NIH Biotech Training Grant and are busy assembling our competitive renewal proposal, which is due this May. We hope to double the number of fellows supported. We need letters of support from our industry partners. As a reminder, the DEB graduate program is the formal training program for the NIH training grant and the number of DEB students is currently up to 86. Each of our students is showcased on the newly revised DEB website (www.deb.ucdavis.edu). In regard to industrial internships for 2006, we are busy placing students. Aminah Ikner started her internship at Novozymes in March, Li Peng and Anh Phung are interviewing with Genentech and many more are in the application process at Amgen, Monsanto-Calgene, Agilent, Pioneer Hibred and Scios. We would like to thank all of our industry affiliates for their support of our training program. Hopefully, we can find a match for all of the students. A number of students graduated in 2005-6 with their PhDs plus a DEB: Susanne Berglund; Amanda Ellsmore Fischer; Ze He; Jien-Ren “Jerry” Ku; Ryann Muir; Sheetal Singh; Bob Ward and Jennifer Weidhaas. Please see the winter edition of Biotechnology Times for more information. Please Come Again on March 31, 2007 (tentative date). With warm regards, Judy Kjelstrom, Director, UC Davis Biotechnology Program 2 NIH Training Program in Biomolecular Technology (NIH-1-T32-GM08799) Bruce D. Hammock, Director Karen McDonald, Co-Director Martina Newell-McGloughlin, Co-Director Executive Committee Faculty: George Bruening (Plant Pathology) Dan Gusfield (Computer Science) Ian Kennedy (Mechanical & Aeronautical Engineering) J. Clark Lagarias (Biochemistry & Molecular Biology) Kit Lam (MED: Internal Medicine (Hemotology/Oncology) John Yoder (Plant Sciences) Industry: Kenneth Gruys, Monsanto, Calgene campus Joel Cherry, Novozymes, Inc. Linda Higgins, Scios Judith A. Kjelstrom, Program Coordinator (Ex-Officio Member) 3 Designated Emphasis in Biotechnology (DEB) Graduate Program www.deb.ucdavis.edu Executive Committee Abhaya Dandekar, Chair David Rocke Karen McDonald Robert Rice (Term ends 6/30/06) Katayoon “Katie” Dehesh (Term starts 7/1/06) Susanne Berglund, Student Member (Term ended 3/31/06) Kou-San Ju, Student Member (Term starts 4/06) Judith A. Kjelstrom Program Coordinator (Ex-Officio Member) 4 UC Davis Biotechnology Program www.biotech.ucdavis.edu Judith A. Kjelstrom, Ph.D., Director Carey Kopay, Assistant Director Cathy Miller, Budget Analyst Marianne Hunter, Event Manager One Shields Ave 301 Life Sciences Davis, CA 95616 [email protected] (530) 752-3260 Fax: (530) 752-4125 5 UC Davis Fifteenth Annual Biotechnology Training Retreat April 8, 2006 Christian Brothers Retreat & Conference Center 6:45 am – Bus departs Davis, Parking Lot #41 (Rebecca Parales, Jason Eiserich) 8:00 – 8:30 am Registration/Continental Breakfast 8:30 – 8:45 am Welcome Bruce Hammock Director, NIH Training Grant in Biomolecular Technology Morning Session Chair Martina Newell McGloughlin Co-Director, NIH Training Grant in Biomolecular Technology 8:45 – 10:20 am Presentations 8:45 am Gian Oddone Mentor: David Block 9:10 am Jill Deikman Monsanto, Calgene Campus 9:35 am Allison Dickey Mentor: Roland Faller 10:00 am Corey Dodge Mentor: Karen McDonald 10:20 – 10:50 am Break / Poster Viewing 10:50 am – 12:20 pm Presentations 10:50 am Aaron Nguyen Scios, Inc. 11:15 am Suzanne Balko Mentor: Tonya Kuhl 11:35 am Jennifer Warren Mentor: Stefan Wuertz 12:00 pm Martina Newell- Bioethics Question (Handout) McGloughlin 12:20 – 2:15 pm Lunch / Poster Viewing Afternoon Session Chair Karen McDonald Co-Director, NIH Training Grant in Biomolecular Technology, DEB Executive Committee 2:15 – 4:00 pm Presentations 2:15 pm Martina Newell- Bioethics Question (Discussion) McGloughlin Chiron Corp. 2:40 pm Indresh Srivastava Mentor:John (Jack) Rutledge 3:05 pm Laura Higgins Novozymes, Inc. 3:30 pm Aubrey Jones Mentor: David Mills 3:55 pm Riccardo LoCascio 4:15 pm Short Break (10 min) 4:25 – 6:00 pm Presentations 4:25 pm Vu Bao Trinh Mentor: Yohei Yokobayashi 4:50 pm Douglas Banks Amgen Inc. 5:15 pm Vannarith Leang Mentor: Robert Powell 5:40pm TBA Genentech 6:15 pm Closing Remarks Bruce Hammock / Martina Newell McGloughlin 6:30 pm – Bus departs Napa 6 2006 Poster Titles A. “Homing Site Requirements of the Lactococcal Goup II Intron In Its Native Host” David A. Sela*, Helen Rawsthorne, and David A. Mills Department of Viticulture and Enology, University of California, Davis, CA 95616 B. “Engineering Oilseed Crop Nutrition” Henry E. Valentin1, Balasulojini Karunanandaa2, Qungang Qi2, Alison Van Eenennaam1, Eric Aasen1, Charlene Levering1, Christine Shewmaker1, Susan Norris2, Kim Lincoln2, Rob Last2, Ming Hao2,Susan Baszis2, Pamela Jensen2, Yun-Hua Wong2, JianJiang2, Farhad Moshiri2, Aundrea Warren2, Mylavarapu Venkatramesh3, Kenneth J. Gruys1.Jennifer Gonzales, AJ Nava, Janet Nelsen, Jeff Haas, Virginia Ursin 1 Monsanto Company, Calgene Campus 2 Monsanto Company 3 Renessen LLC C. “Lipolysis products alter protein and lipid structural characteristics in the plasma membranes of human monocytes” Laura J Higgins1*, Nabil M Saad2, Oliver Fiehn2, John C Rutledge1 1Dept of Internal Medicine, 2Genome Center, University of California, Davis, 95616 D. “Immunophenotyping of Leukocytes on Antibody Microarrays” He Zhu*, Kazuhiko Sekine, Mehmet Toner, and Alexander Revzin Section of Microbiology, University of California, Davis, CA, 95616 E. “High Affinity High Specificity Alpha4 Beta1 Integrin Targeting Peptides for Lymphoid Cancers” Li Peng*, Ruiwu Liu, Jan Marik, Xiaobing Wang, Yoshikazu Takada, Kit S. Lam Department of Internal Medicine, UC Davis Cancer Center, University of California Davis, 4501 X Street, Sacramento, California 95817 F. “α-Tubulin Detyrosination: A Molecular Switch for Regulating Vascular Smooth Muscle Cell Proliferation” Anh D. Phung1*, Karel Souček1, Lukáš Kubala1, Richart W. Harper1, J. Chloë Bulinski4,5 & Jason P. Eiserich1, 2, 3 1Department of Internal Medicine, 2Department of Physiology and Membrane Biology, and 3Cancer Center, University of California, Davis, California 95616 USA. 4Department of Biological Sciences and 5Department of Pathology & Cell Biology, Columbia University, New York, NY 10027, USA. G. “Novel Biofunctional Core/Shell Quantum Dots for Multimodality Imaging” Heather A. Palko1+, Zane S. Starkewolfe1*+, Shizhong Wang1,3, Li Peng2*,
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