Presented by the Department of Orthopaedic Surgery University of California, San Francisco

University of California San Francisco

6TH INTERNATIONAL CONFERENCE ADVANCES IN ORTHOPAEDIC OSSEOINTEGRATION

MARCH 26-27, 2015 MEDICAL EDUCATION AND RESEARCH INSTITUTE OF NEVADA (MERIN) HENDERSON, NEVADA, USA

ORTHOPAEDIC ONCOLOGY REVIEW COURSE

MARCH 29, 2015 VDARA HOTEL AND SPA LAS VEGAS, NEVADA, USA 6TH INTERNATIONAL CONFERENCE ADVANCES IN ORTHOPAEDIC OSSEOINTEGRATION March 26-27, 2015 Over the past fifty years, great strides have ACCREDITATION The University of been made in the study of osseointegration, California, San Francisco and from these findings new therapeutic options School of Medicine (UCSF) is accredited by have emerged. Advances in basic science the Accreditation Council for Continuing Medical and engineering have been translated into Education to provide clinically beneficial technologies in the fields continuing medical education for physicians. of arthroplasty, oncology, and prosthetic Physicians rehabilitation. In this symposium, we will UCSF designates this live activity for a bring together international experts to maximum of 13.00 AMA explore our current understanding of the PRA Category 1 Credit(s) TM . Physicians principles, techniques, and clinical outcomes should claim only the credit commensurate of reconstructive therapies utilizing with the extent of their osseointegration technologies. participation in the activity. This CME activity meets the requirements under TARGET AUDIENCE California Assembly Orthopaedic oncology and arthroplasty attending Bill 1195, continuing surgeons; Orthopaedic residents; Prosthetists; Veterinary education and cultural and linguistic competency. professionals; Basic scientists; Allied health professionals in the fields of reconstructive and rehabilitative medicine. The approved credits shown above include 9.00 (main course) and 4.00 (wet lab). S To assemble a diverse faculty of osseointegration E experts to review and expand upon contemporary Physician Assistants V I practice: The American Academy of T Physician Assistants

C • To better apply the basic science and clinical (AAPA) accepts courses E developments across disciplines in the field of approved for AMA PRA J Category 1 Credit™ as B osseointegration in practice.

O meeting the continuing • To appreciate the theoretical basis and improve education requirements L for license renewal.

A practical clinical advantages of compressive

N osseointegration technology for oncologic limb Nursing Credit O

I salvage and revision arthroplasty patients. For the purpose of

T recertification, the

A • To broaden the potential utility of American Nurses C osseointegration techniques for improving Credentialing Center U the clinical outcomes of amputee patients. accepts AMA PRA D Category 1 Credit™ E issued by organizations accredited by the ACCME.

MERIN THURSDAY, MARCH 26, 2015 • MERIN, HENDERSON, NV, USA MINI-SYMPOSIUM I: COMPRESSIVE OSSEOINTEGRATION 6:30-7:15am Continental breakfast 7:15-7:30am Welcome and Introductory Remarks Richard J. O’Donnell, MD, San Francisco, CA, USA 7:30-7:45am Proximal Femoral and Proximal Tibial Compressive Osseointegration: Intermediate Term Outcomes Wustrack RL, O’Donnell RJ; San Francisco, CA, USA 7:45-8:00am Distal Femoral Compressive Osseointegration: Intermediate Term Outcomes in Oncologic and Non-Oncologic Patients Hackney L, O’Donnell RJ, Wustrack RL; San Francisco, CA, USA 8:00-8:15am Management of Deep Prosthetic Infection in Compressive Osseointegration Langhammer C, Wustrack RL, O’Donnell RJ; San Francisco, CA, USA 8:15-8:30am Panel Discussion: Compressive Osseointegration Technology Moderator: Richard J. O’Donnell, MD, San Francisco, CA, USA CONVENTIONAL OSSEOINTEGRATION BASIC AND TRANSLATIONAL STUDIES 8:30-8:45am Immunohistochemical Techniques for Studying Skin-Implant Interfaces: Stepping Beyond Monochromatic Stains Jeyapalina S, Edwards A, Bachus KN, Beck JP; Salt Lake City, UT, USA 8:45-9:00am Biomaterial Associated Infections: How Can We Address Biofilm Forming Bacteria? Trobos M, Zaborowska M, Brånemark R, Thomsen P; Gothenburg, SE 9:00-9:15am Effect of Proximal Stem Geometry on Initial Fixation Strength of Transfemoral Porous Coated Percutaneous Osseointegrated Implant Drew AJ,*Kubiak EN,* Longo JAx, Dodd K,Vinciguerra J, +Bachus KN;* *Salt Lake City, UT, USA; xScottsdale, AZ, USA; +Austin, TX, USA 9:15-9:30am Novel Methods for High Resolution Biomaterial Interface Analysis Thomsen P, Palmquist A, Brånemark R; Gothenburg, SE 9:30-9:45am Evaluation of Bone Mineral Density and Bone Markers in Femoral Amputees Prior to Osseointegrated Implant Surgery Hansen RL, Stilling M, Søballe K, Petersen KK, Jørgensen PH; Aarhus, DK 9:45-10:00am Evaluation of Peri-Implant Bone Mineral Density Changes after Femoral Osseointegrated Prosthesis Surgery Hansen RL, Stilling M, Søballe K, Petersen KK, Jørgensen PH; Aarhus, DK 10:00-10:15am Evaluation Framework to Assess Benefits and Harms of Bone-Anchored Prosthesis Frossard L; Brisbane and Maroochydore, AU 10:15-10:30am Panel Discussion: Basic and Translational Osseointegration Science Rosanna L. Wustrack, MD, San Francisco, CA, USA 10:30-10:45am Morning Break CLINICAL STUDIES, I 10:45-11:00am Osseointegrated Prosthetic Limb for Amputees: Over One Hundred Cases Khemka A, Frossard L, Lord SJ, Bosley B, Al Muderis M; Sydney, AU 11:00-11:15am OPRA Study: Preliminary 5 Year Results Berlin Ö, Brånemark R; Gothenburg, SE 11:15-11:30am Health-Related Quality of Life of Individuals with Transfemoral Amputation Fitted with the Transcutaneous Bone Anchoring Prosthesis Following the OGAAP Khemka A, Frossard L, Lord SJ, Bosley B, Al Muderis M; Sydney, AU 11:30-11:45am Prosthetic Function with Osseointegrated Transfemoral Prostheses – Long Term Results from the OPRA Study Hagberg K, Berlin Ö, Brånemark R; Gothenburg SE 11:45am-12:00pm Panel Discussion: Clinical Osseointegration Studies Jonathan A. Forsberg, MD, Bethesda, MD, USA 12:00-12:30pm Working Lunch • The Military Osseointegration Program Jonathan A. Forsberg, MD, Bethesda, MD, USA 12:30-1:00pm An Osseointegrated Human-Machine Gateway for Long-Term Sensory Feedback and Motor Control of Artificial Limbs: A Patient’s Perspective Max J. Ortiz Catalán, MD,* and Rickard Brånemark*+, MD, MSc, PhD,* +*Gothenburg, SE and +San Francisco, CA, USA CLINICAL STUDIES, II 1:00-1:15pm Osseointegrated Prosthetic Limb for Amputees: Single Stage Surgery Khemka A, Frossard L, Lord SJ, Bosley B, Al Muderis M; Sydney, AU 1:15-1:30pm Safety of Osseointegrated Prosthesis for Trans-Femoral Amputees Al Muderis M, Khemka A, Lord SJ, Van de Meent H, Frolke JP; Sydney, AU 1:30-1:45pm Clinical Outcome of Osseointegrated Prosthesis for the Trans-Femoral Amputees in Denmark Jørgensen PH, Petersen KP, Hansen RL; Aarhus, DK 1:45-2:00pm Transcutaneous Bone-anchoring Prosthesis with Hip Replacement: A Novel Treatment for Amputees Khemka A, Frossard L, Lord SJ, Bosley B, Al Muderis M; Sydney, AU 2:00-2:15pm Transcutaneous Bone-anchoring Prosthesis with Knee Replacement: A Novel Treatment for Amputees Khemka A, Frossard L, Lord SJ, Bosley B, Al Muderis M; Sydney, AU 2:15-2:30pm Afternoon Break CLINICAL STUDIES, III 2:30-2:45pm Treatment of Patients with Transhumeral Amputation Using Osseointegrated Percutaneous Implants: A Retrospective Follow Up Caine-Winterberger K, Kulbacka-Ortiz K, Brånemark R; Gothenburg, SE 2:45-3:00pm Implant Survival, Adverse Events, and Bone Remodeling of Osseointegrated Implants for Transhumeral Amputees Tsikandylakis G, Berlin Ö, Brånemark R; Gothenburg, SE 3:00-3:15pm Treatment of Patients with Transradial Amputation Using Osseointegrated Percutaneous Implants: A Retrospective Follow-Up Kulbacka-Ortiz K, Caine-Winterberger K, Brånemark R; Gothenburg, SE 3:15-3:30pm Treatment of Patients with Transmetacarpal I Amputation Using Osseointegrated Percutaneous Implants: A Retrospective Follow-Up Brånemark R, Kulbacka-Ortiz K, Caine-Winterberger K; Gothenburg, SE 3:30-3:45pm Osseointegrated Prosthesis for Upper Limb Amputees: Danish Experience Jørgensen PH, Petersen KK; Aarhus, DK 3:45-4:00pm Panel Discussion: Clinical Osseointegration Studies Örjan Berlin, MD, Gothenburg, SE MINI-SYMPOSIUM II: OSSEOINTEGRATION CASE STUDIES 4:00-4:05pm Total Femoral and Proximal Tibial Compressive Osseointegration: 12-Year Follow-Up Legaspi KN, Wustrack RL, O’Donnell RJ; San Francisco, CA, USA 4:05-4:10pm Femoral Pathologic Fracture in Morbidly Obese Patient Managed with External Fixation and Compressive Osseointegration Choo KJ, Morshed S, Wustrack RL, O’Donnell RJ; San Francisco, CA, USA 4:10-4:20pm Bilateral Transtibial OPRA Bertrand-Marchand M; Montpellier, FR 4:20-4:25pm Ultrashort Transhumeral Amputation Brånemark R; Gothenburg, SE 4:25-4:35pm Ultrashort Transfemoral Amputation Treated with Custom Designed Implant Bertrand-Marchand M; +Brånemark R;*+Montpellier, FR; *Gothenburg, SE 4:35-4:45pm Panel Discussion: Pushing the Osseointegration Envelope Moderator: Rickard Brånemark, MD, MSc, PhD, Gothenburg, SE and San Francisco, CA, USA 4:45-4:50pm In Memoriam: Ignace Samson, MD Richard J. O’Donnell, MD, San Francisco, CA, USA 4:50-5:00pm Closing Remarks: Orthopaedic Osseointegration and the OSOS Richard J. O’Donnell, MD, San Francisco, CA, USA FRIDAY, MARCH 27, 2015 • MERIN, HENDERSON, NV, USA OSSEOINTEGRATION: SURGICAL TECHNIQUES 7:30-8:15am Continental breakfast 8:15-8:30am Welcome and Introductory Remarks Richard J. O’Donnell, MD, San Francisco, CA, USA 8:30-9:00am Compressive Osseointegration: Practical Aspects and Surgical Technique Richard J. O’Donnell, MD, San Francisco, CA, USA 9:00-9:30am Conventional Osseointegration: Practical Aspects and Surgical Technique Rickard Brånemark, MD, MSc, PhD, Gothenburg, SE and San Francisco, CA, USA 9:30-11:30pm Saw Bone Demonstrations and Hands-On Lab: Compressive, Conventional, and Prosthetic Stations Richard J. O’Donnell, MD, San Francisco, CA, USA Rickard Brånemark, MD, MSc, PhD, Gothenburg, SE and San Francisco, CA, USA 11:30-11:50pm Compressive Osseointegration: Interesting Cases, Pearls, Pitfalls, and Rehabilitation Richard J. O’Donnell, MD, San Francisco, CA, USA 11:50-12:10pm Conventional Osseointegration: Interesting Cases, Pearls, Pitfalls, and Rehabilitation Rickard Brånemark, MD, MSc, PhD, Gothenburg, SE and San Francisco, CA, USA 12:10-12:30pm Osseointegration: Question and Answer • Closing Remarks Richard J. O’Donnell, MD, University of California, San Francisco, CA, USA Rickard Brånemark, MD, MSc, PhD, Gothenburg, SE and San Francisco, CA, USA 12:30pm Adjourn ORTHOPAEDIC ONCOLOGY REVIEW COURSE March 29, 2015 This one-day, intensive review course is designed for ACCREDITATION the busy professional intent on mastering the essentials The University of of orthopaedic oncology. Concise yet comprehensive California, San Francisco School of Medicine instruction will be provided in the mutlidsiciplinary (UCSF) is accredited by evaluation and management of the musculoskeletal the Accreditation Council oncology patient. Topics include radiology, pathology, for Continuing Medical and orthopaedic surgical techniques. Question-and- Education to provide answer sessions will prepare the attendee for in-training, continuing medical education for physicians. board, and re-certification examinations. Physicians UCSF designates this TARGET AUDIENCE live activity for a maximum of 8.50 AMA PRA Orthopaedic residents, fellows, and attending surgeons; Category 1 Credits TM . Pathologists; Radiologists; General surgical oncologists; Physicians should claim Nurses and allied health professionals involved in the only credit commensurate care of orthopaedic oncology patients. with the extent of their participation in the activity. Physician Assistants The American Academy S To provide a highly organized, efficient, thorough of Physician Assistants E conference to review key orthopaedic oncology principles (AAPA) accepts courses V in order to improve competency in patient care. After I course completion, attendees will be prepared to: approved for AMA PRA T Category 1 Credit TM as

C • Understand and be able to use the tools of radiologic meeting the continuing

E and pathologic studies in the diagnosis and staging education requirements J of musculoskeletal tumors and tumor-like conditions. for license renewal. B Pertinent, "need-to-know" topics will range from basic Nursing Credit O

science advances to essentials of microscopic histology. For the purpose of L • Employ the strategy of using multiple disciplines in recertification, the A the care of the musculoskeletal oncology patient. American Nurses N State-of-the-art orthopaedic surgical techniques Credentialing Center

O accepts AMA PRA

I involved in the care of the limb salvage and amputee Category 1 Credit TM T patient will be covered. issued by organizations A • Face current practice gaps in orthopaedic oncologic accredited by the ACCME. C patient care, including: careful diagnostic work-up; U proper approach to biopsy issues; completion of staging D evaluation; appropriate treatment; avoidance and E management of complications; and provision of expert aftercare. • Succeed in professional examinations and the care of the orthopaedic oncology patient.

Vdara ORTHOPAEDIC ONCOLOGY REVIEW COURSE 7:00-8:00am Continental Breakfast / Registration 8:00-9:30am Topics 1-90 Orthopaedic Oncology: Introduction, Evaluation, Diagnosis, Staging, Treatment, Aftercare and Surveillance • Richard J. O’Donnell, MD 9:30-9:45am Questions 1-30 • Review Session Richard J. O’Donnell, MD 9:45-11:15am Topics 91-180 • Benign and Malignant Soft Tissue Tumors Raffi S. Avedian, MD 11:15-11:30am Questions 31-60 • Review Session Raffi S. Avedian, MD 11:30am-12:00pm Working Lunch • Principles of Musculoskeletal Radiology Thomas M. Link, MD, PhD 12:00-12:30pm Working Lunch • Principles of Orthopaedic Pathology Andrew E. Horvai, MD, PhD 12:30-1:00pm Working Lunch • Principles of Radiation Oncology Steven Braunstein, MD, PhD 1:00-2:30pm Topics 181-270 • Benign and Malignant Bone Tumors Robert J. Steffner, MD 2:30-2:45pm Questions 61-90 • Review Session Robert J. Steffner, MD 2:45-4:15pm Topics 270-365 • Metastatic Bone Disease, Osteomyelitis, Osteoporosis, Metabolic Bone Disease, Pseudotumors, Tumor-like Conditions Rosanna L. Wustrack, MD 4:15-4:30pm Questions 91-120 • Review Session James O. Johnston, MD 4:30pm Adjourn

PROGRAM CHAIRS AND Örjan Berlin, MD PLANNING COMMITTEE PLANNING COMMITTEE Gothenburg, SE Richard J. O’Donnell, MD Richard J. O’Donnell, MD Kerstin Hagberg, RPT, PhD (San Francisco, USA) San Francisco, USA Gothenburg, SE Rosanna L. Wustrack, MD Rickard Brånemark, MD, MSC, Jonathan A. Forsberg, MD (San Francisco, USA) PhD Bethesda, MD Raffi S. Avedian, MD Gothenburg, Sweden Max J. Ortiz Catalán, PhD (Palo Alto, CA) San Francisco, CA, USA Gothenburg, SE Robert J. Steffner, MD Rosanna L. Wustrack, MD Munjed Al-Muderis, MD (Davis, CA) San Francisco, USA Sydney, AU COURSE FACULTY COURSE FACULTY Kerstin Caine-Winterberger, RPT (All University of California, San (All University of California, San Francisco unless otherwise noted) Francisco unless otherwise noted) Gothenburg, SE Georgios Tsikandylakis, MD Raffi S. Avedian, MD Lauren A. Hackney, MD (Palo Alto, CA) San Francisco, CA, USA Gothenburg, SE Katarzyna Kulbacka-Ortiz Steven Braunstein, MD, PhD Christopher C. Langhammer, MD (San Francisco, USA) San Francisco, CA, USA Gothenburg, SE Peter H. Jørgensen, MD, DmSc Andrew E. Horvai, MD, PhD Sujee Jeyapalina, (PhD) (San Francisco, CA) Salt Lake City UT, USA Aarhus, DK Kevin J. Choo, MD James O. Johnston, MD Margarita Trobos, PhD (San Francisco, CA) Gothenburg, SE San Francisco, CA Marion Bertrand-Marchand, MD Thomas M. Link, MD, PhD Alex J. Drew, (PhD) (San Francisco, CA) Salt Lake City, UT, USA Montpellier, FR Richard J. O’Donnell, MD Peter Thomsen, MD (San Francisco, USA) Gothenburg, SE Robert J. Steffner, MD Rehne L. Hansen, MD, PhD (Davis, CA) Aarhus, DK Rosanna L. Wustrack, MD Laurent Frossard, PhD (San Francisco, USA) Brisbane and Maroochydore, AU Aditya Khemka, MBBS, MS Ortho, PhD Sydney, AU

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. Mail to : UCSF Office of CME Online registration: www.cme.ucsf.edu

w P.O. Box 45368 Registration Information: (415) 476-5808

w San Francisco, CA 94145-0368 Course Information: (415) 476-4251

w Fax: (415) 502-1795

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REGISTRATION FEES (Receipt/Confirmation will be mailed within two to four weeks): MMJ15003: 6th International Conference: MMC15020: Orthopaedic Oncology Review Advances in Orthopaedic Osseointegration Course March 26: $350 MD, DMD, DDS FEES: $250 MD $250 AHP, PA’s and Residents $150 AHP, PA’s and Residents $150 Military $150 Military March 27: Osseointegration Wet Lab $150 MD, DMD, DDS, and AHP Make checks payable to UC Regent s

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Refund Policy: Cancellations received in writing before the first day of the course will be refunded,

N less a $75 administrative fee. No refunds will be made on cancellations received after that date. Please check our website for up to date information on the course at www.cme.ucsf.edu O

I VDARA HOTEL & SPA M EDIC AL EDUCATION AND RESEARCH T 2600 W. Harmon Avenue • Las Vegas, NV 89158 IN ST ITUTE OF NEVADA (MERIN)

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